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MCID: GLM004
MIFTS: 53

Gliomatosis Cerebri

Categories: Cancer diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Gliomatosis Cerebri

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MalaCards integrated aliases for Gliomatosis Cerebri:

Name: Gliomatosis Cerebri 12 76 53 59 55 15 73
Neoplasms, Neuroepithelial 44
Astrocytosis Cerebri 12

Characteristics:

Orphanet epidemiological data:

59
gliomatosis cerebri
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6128
MeSH 44 D018302
NCIt 50 C4318
SNOMED-CT 68 26138003
Orphanet 59 ORPHA251582
UMLS via Orphanet 74 C0334576
ICD10 via Orphanet 34 C71.0
UMLS 73 C0334576
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Summaries for Gliomatosis Cerebri

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NIH Rare Diseases : 53 Gliomatosis cerebri is a type of malignant (cancerous) brain tumor called a glioblastoma that develops from a specific type of brain cell called an astrocyte. It involves at least three sections (lobes) within the main part of the brain (cerebrum). It may also affect both sides of the cerebrum as well as the nerve cells within the brain (grey matter). There are two types of gliomatosis cerebri. Type 1 (classic form) is characterized by scattered and widespread tumor cells and no apparent mass or tumor, while type 2 has similar characteristics in addition to a detectable mass or tumor. Signs and symptoms of gliomatosis cerebri may include personality changes, memory disturbance, headaches, and seizures. Because this type of cancer can be found in many areas of the brain, it can be challenging to treat. Treatment might include surgery to remove areas of the brain affected (when possible), radiation therapy, and chemotherapy.

MalaCards based summary : Gliomatosis Cerebri, also known as neoplasms, neuroepithelial, is related to glioma susceptibility 1 and glioblastoma, and has symptoms including seizures, headache and sensory manifestations. An important gene associated with Gliomatosis Cerebri is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are PI3K/AKT activation and Phospholipase-C Pathway. The drugs Dacarbazine and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary, and related phenotypes are Increased cell death HMECs cells and digestive/alimentary

Disease Ontology : 12 A brain cancer that is characterized by a pattern of diffuse infiltration of the brain that affect various areas of the cerebral lobes and has material basis in abnormally proliferating cells, derives from glial cells.

Wikipedia : 76 Gliomatosis cerebri (infiltrative diffuse astrocytosis) is a rare primary brain tumor. It is commonly... more...

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Related Diseases for Gliomatosis Cerebri

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Diseases related to Gliomatosis Cerebri via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 30.1 GFAP IDH1 TP53
2 glioblastoma 30.0 EGFR IDH1 MDM2 PTEN TP53
3 glioma 29.7 EGFR IDH1 MDM2 PTEN TP53
4 hydrocephalus 29.6 GFAP NES PTEN TP53
5 medulloblastoma 29.1 EGFR GFAP IDH1 NES PTEN TP53
6 glioblastoma multiforme 28.8 EGFR GFAP IDH1 MDM2 NES PTEN
7 encephalitis 10.4
8 dementia 10.3
9 extraventricular neurocytoma 10.2 GFAP IDH1
10 angiocentric glioma 10.2 GFAP IDH1
11 pilocytic astrocytoma 10.2 GFAP IDH1
12 gemistocytic astrocytoma 10.2 GFAP PTEN
13 adult astrocytic tumour 10.2 IDH1 PTEN
14 intracranial chondrosarcoma 10.2 IDH1 TP53
15 cerebellar astrocytoma 10.2 IDH1 TP53
16 frontal convexity meningioma 10.2 GFAP TP53
17 gliofibroma 10.2 GFAP TP53
18 cerebral convexity meningioma 10.2 GFAP TP53
19 cellular ependymoma 10.2 GFAP TP53
20 cerebellopontine angle tumor 10.2 GFAP IDH1
21 protoplasmic astrocytoma 10.2 GFAP TP53
22 meninges sarcoma 10.2 GFAP TP53
23 cerebral neuroblastoma 10.2 GFAP TP53
24 spinal cancer 10.2 GFAP TP53
25 cerebral ventricle cancer 10.2 GFAP TP53
26 chordoid glioma 10.2 GFAP TP53
27 malignant ependymoma 10.2 GFAP TP53
28 epilepsy 10.2
29 acute disseminated encephalomyelitis 10.2
30 viral encephalitis 10.2
31 intracranial hypertension 10.2
32 benign glioma 10.2 GFAP TP53
33 synchronous bilateral breast carcinoma 10.2 PTEN TP53
34 papilloma of choroid plexus 10.2 GFAP TP53
35 female reproductive endometrioid cancer 10.2 PTEN TP53
36 periosteal chondrosarcoma 10.1 IDH1 MDM2
37 choroid plexus cancer 10.1 GFAP TP53
38 anaplastic oligodendroglioma 10.1 EGFR GFAP
39 inflammatory mfh 10.1 GFAP MDM2
40 necrotizing sialometaplasia 10.1 GFAP TP53
41 cystic teratoma 10.1 GFAP TP53
42 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.1 PTEN TP53
43 central nervous system benign neoplasm 10.1 GFAP TP53
44 nervous system benign neoplasm 10.1 GFAP TP53
45 cerebellar liponeurocytoma 10.1 GFAP TP53
46 juvenile pilocytic astrocytoma 10.1 GFAP TP53
47 bile duct adenocarcinoma 10.1 IDH1 TP53
48 brain ependymoma 10.1 EGFR TP53
49 ring chromosome 7 10.1 MDM2 TP53
50 zika virus infection 10.1 MDM2 TP53

Graphical network of the top 20 diseases related to Gliomatosis Cerebri:



Diseases related to Gliomatosis Cerebri
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Symptoms & Phenotypes for Gliomatosis Cerebri

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UMLS symptoms related to Gliomatosis Cerebri:


seizures, headache, sensory manifestations

GenomeRNAi Phenotypes related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death HMECs cells GR00103-A-0 8.92 EGFR MDM2 PTEN TP53

MGI Mouse Phenotypes related to Gliomatosis Cerebri:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.65 EGFR GFAP MDM2 PTEN TP53
2 muscle MP:0005369 9.55 EGFR GFAP MDM2 PTEN TP53
3 normal MP:0002873 9.43 EGFR GFAP INA MDM2 PTEN TP53
4 pigmentation MP:0001186 8.92 EGFR MDM2 PTEN TP53
Sources

Drugs & Therapeutics for Gliomatosis Cerebri

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Drugs for Gliomatosis Cerebri (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
2
Valproic Acid Approved, Investigational Phase 3,Phase 2 99-66-1 3121
3
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
4
Temozolomide Approved, Investigational Phase 3,Phase 2 85622-93-1 5394
5
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
6
Cyproheptadine Approved Phase 3 129-03-3 2913
7 Dermatologic Agents Phase 3,Phase 1
8 Anthelmintics Phase 3
9 Chloroquine diphosphate Phase 3 50-63-5
10 Anti-Inflammatory Agents, Non-Steroidal Phase 3
11 Antiprotozoal Agents Phase 3
12 Antiparasitic Agents Phase 3
13 Psychotropic Drugs Phase 3,Phase 2
14 Antirheumatic Agents Phase 3
15 Anti-Inflammatory Agents Phase 3,Phase 1
16 Analgesics Phase 3
17 Anti-Infective Agents Phase 3,Phase 2
18 Neurotransmitter Agents Phase 3,Phase 2,Not Applicable
19 Analgesics, Non-Narcotic Phase 3
20 Alkylating Agents Phase 3,Phase 2
21 GABA Agents Phase 3,Phase 2
22 Peripheral Nervous System Agents Phase 3,Phase 1
23 Antimalarials Phase 3
24 Anticonvulsants Phase 3,Phase 2
25 Tranquilizing Agents Phase 3,Phase 2
26 Antineoplastic Agents, Alkylating Phase 3,Phase 2
27 Pharmaceutical Solutions Phase 3
28 Antimanic Agents Phase 3,Phase 2
29 Central Nervous System Depressants Phase 3,Phase 2
30 Serotonin Agents Phase 3
31 Anti-Allergic Agents Phase 3
32 Serotonin Antagonists Phase 3
33 Histamine H1 Antagonists Phase 3
34
Histamine Phosphate Phase 3 51-74-1 65513
35 Antipruritics Phase 3
36 Histamine Antagonists Phase 3
37 Gastrointestinal Agents Phase 3,Phase 1,Not Applicable
38
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
39
Gefitinib Approved, Investigational Phase 1, Phase 2 184475-35-2 123631
40
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
41
Bevacizumab Approved, Investigational Phase 2 216974-75-3
42
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
43 tannic acid Approved Phase 2
44
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2,Phase 1 1177-87-3
45
Iodine Approved, Investigational Phase 2 7553-56-2 807
46
Promethazine Approved, Investigational Phase 2 60-87-7 4927
47
Acetaminophen Approved Phase 2 103-90-2 1983
48
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
49
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
50
Doxil Approved June 1999 Phase 2 31703

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) Recruiting NCT03243461 Phase 3 Temozolomide + Valproic Acid;Temozolomide + Chloroquine
2 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
3 Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas Completed NCT00042991 Phase 1, Phase 2 gefitinib
4 Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma Recruiting NCT02758366 Phase 2 Doxorubicin
5 Valproic Acid and Radiation Followed by Maintenance Valproic Acid and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma Active, not recruiting NCT00879437 Phase 2 Valproic acid;Bevacizumab
6 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
7 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
8 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
9 Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Recruiting NCT02255461 Phase 1 palbociclib isethionate
10 Oncolytic HSV-1716 in Treating Younger Patients With Refractory or Recurrent High Grade Glioma That Can Be Removed By Surgery Terminated NCT02031965 Phase 1 dexamethasone
11 Rare CNS Tumors Outcomes &Risk Recruiting NCT03251989
12 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 Not Applicable 18F-fluoro-dihydroxyphenylalanine
13 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Gliomatosis Cerebri

Cochrane evidence based reviews: neoplasms, neuroepithelial

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Genetic Tests for Gliomatosis Cerebri

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Anatomical Context for Gliomatosis Cerebri

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MalaCards organs/tissues related to Gliomatosis Cerebri:

41
Brain, Spinal Cord, Pituitary, Lung, Bone, Colon, Pancreas
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Publications for Gliomatosis Cerebri

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Articles related to Gliomatosis Cerebri:

(show top 50) (show all 246)
# Title Authors Year
1
Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy. ( 29861635 )
2018
2
Incidence and survival of gliomatosis cerebri: a population-based cancer registration study. ( 29464663 )
2018
3
Gliomatosis Cerebri: A Rare Brain Tumor. ( 29459616 )
2018
4
Gliomatosis cerebri: a consensus summary report from the Second International Gliomatosis cerebri Group Meeting, June 22-23, 2017, Bethesda, USA. ( 29998396 )
2018
5
Wide Range of Clinical Outcomes in Patients with Gliomatosis Cerebri Growth Pattern: A Clinical, Radiographic, and Histopathologic Study. ( 30097523 )
2018
6
Clinical, neuroimaging and histopathological features of gliomatosis cerebri: a systematic review based on synthesis of published individual patient data. ( 30117023 )
2018
7
Prognostic Factors and Survival of Gliomatosis Cerebri: A Systematic Review and Meta-Analysis. ( 30172970 )
2018
8
An Adolescent Presenting With Seizures as a Symptom of Gliomatosis Cerebri. ( 28486262 )
2017
9
Molecular alterations in pediatric gliomatosis cerebri are similar to those in less invasive forms of pediatric diffuse glioma. ( 28421462 )
2017
10
Bevacizumab for Patients with Recurrent Gliomas Presenting with a Gliomatosis Cerebri Growth Pattern. ( 28353668 )
2017
11
Gliomatosis cerebri in a 10-year-old male patient. ( 28484570 )
2017
12
Gliomatosis cerebri: Prognosis based on current molecular markers. ( 28539209 )
2017
13
Gliomatosis Cerebri: Current Understanding and Controversies. ( 28824876 )
2017
14
Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis. ( 28366748 )
2017
15
Magnetic resonance imaging features of canine gliomatosis cerebri. ( 29110365 )
2017
16
Pediatric Gliomatosis Cerebri: A Review of 15 Years. ( 26239491 )
2016
17
Gliomatosis cerebri: no evidence for a separate brain tumor entity. ( 26493382 )
2016
18
Perioperative risk assessment of patients with gliomatosis cerebri. ( 27836704 )
2016
19
Radiology Case of the Month: Gliomatosis Cerebri. ( 27598892 )
2016
20
Gliomatosis cerebri: A consensus summary report from the First International Gliomatosis cerebri Group Meeting, March 26-27, 2015, Paris, France. ( 27466787 )
2016
21
Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas. ( 26744350 )
2016
22
Gliomatosis Cerebri in the Brain of a Cat. ( 29056722 )
2016
23
Nanostructured lipid carriers based temozolomide and gene co-encapsulated nanomedicine for gliomatosis cerebri combination therapy. ( 26017099 )
2016
24
Erratum to: Gliomatosis cerebri: no evidence for a separate brain tumor entity. ( 26744347 )
2016
25
Gliomatosis cerebri: Case series of six cases with review of literature. ( 26752659 )
2015
26
Gliomatosis cerebri in a 12-year-old patient. ( 25662824 )
2015
27
"Fungimitosis": Invasive fulminant Aspergillus brain infection mimicking gliomatosis cerebri. ( 26053824 )
2015
28
Corticosteroid sensitivity in gliomatosis cerebri delays diagnosis. ( 25922538 )
2015
29
Gliomatosis cerebri having a poor performance status without recurrence after radiotherapy: a single institutional experience. ( 25569296 )
2015
30
Gliomatosis cerebri with spinal metastasis presenting with chronic meningitis in two boys. ( 26318497 )
2015
31
Gliomatosis cerebri mimicking encephalitis evaluated using fluorine-18 fluorodeoxyglucose: Positron emission tomography/computed tomography. ( 25589818 )
2015
32
Gliomatosis cerebri in L-2-hydroxyglutaric aciduria. ( 25997888 )
2015
33
Pediatric gliomatosis cerebri mimicking tubercular encephalitis. ( 26962350 )
2015
34
Gliomatosis Cerebri Type 1 with Extensive Involvement of the Spinal Cord and BRAF V600E Mutation. ( 24353007 )
2014
35
A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes(a8!) ( 24945683 )
2014
36
Clinical manifestations and imaging characteristics of gliomatosis cerebri with pathological confirmation. ( 24969874 )
2014
37
Gliomatosis cerebri mimicking viral encephalitis in a 4-year-old child. ( 24717581 )
2014
38
Procarbazine, CCNU, and Vincristine Chemotherapy in Gliomatosis Cerebri. ( 25408934 )
2014
39
Patterns of presentation and failure in patients with gliomatosis cerebri treated with partial-brain radiation therapy. ( 24845411 )
2014
40
Nocardia abscesses mimicking tumor progression in gliomatosis cerebri responding to temozolomide. ( 25189790 )
2014
41
Exclusive radiotherapy for gliomatosis cerebri: long-term follow-up at a single institution. ( 24474572 )
2014
42
Gliomatosis cerebri: a review. ( 24390814 )
2014
43
Gliomatosis cerebri mimicking acute viral encephalitis and with malignant transformation of partial lesions: A case report. ( 25120625 )
2014
44
Primary gliomatosis cerebri involving gray matter in pediatrics: a distinct entity? A multicenter study of 14 cases. ( 23306961 )
2013
45
Letter to the editor: gliomatosis cerebri. ( 23198839 )
2013
46
Bilateral ptosis as initial presentation of gliomatosis cerebri: case report. ( 23427031 )
2013
47
Infiltration of the Optic Chiasm, Nerve, and Disc by Gliomatosis Cerebri. ( 23287703 )
2013
48
Teaching NeuroImages: diffuse cerebral neurosarcoidosis mimicking gliomatosis cerebri. ( 23940026 )
2013
49
18F FDG PET/CT in a child with gliomatosis cerebri. ( 23122744 )
2013
50
Juvenile parkinsonism as an initial manifestation of gliomatosis cerebri. ( 24158273 )
2013
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Variations for Gliomatosis Cerebri

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Expression for Gliomatosis Cerebri

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Search GEO for disease gene expression data for Gliomatosis Cerebri.
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Pathways for Gliomatosis Cerebri

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Pathways related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
PI3K/AKT activation 66
Show member pathways
 12.91 EGFR MDM2 PTEN TP53
2
Phospholipase-C Pathway 64
Show member pathways
 12.86 EGFR MDM2 PTEN TP53
3
Human cytomegalovirus infection 37
Show member pathways
 12.85 EGFR MDM2 PTEN TP53
4
PI3K-Akt signaling pathway 37
Show member pathways
 12.78 EGFR MDM2 PTEN TP53
5
Endometrial cancer 37
Show member pathways
 12.66 EGFR MDM2 PTEN TP53
6
Pathways in cancer 37
12.62 EGFR MDM2 PTEN TP53
7
Glioma 37
Show member pathways
 12.55 EGFR MDM2 PTEN TP53
8
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.5 EGFR MDM2 PTEN TP53
9
mTOR signaling pathway (KEGG) 65
Show member pathways
 12.32 EGFR PTEN TP53
10
ErbB signaling pathway 1 37
Show member pathways
 12.3 EGFR MDM2 TP53
11
Apoptosis Pathway 72
Show member pathways
 12.27 EGFR MDM2 TP53
12
MicroRNAs in cancer 37
12.23 EGFR MDM2 PTEN TP53
13
Development IGF-1 receptor signaling 22
Show member pathways
 12.21 MDM2 PTEN TP53
14
DNA Damage Response 1
Show member pathways
 12.19 MDM2 PTEN TP53
15
Proteoglycans in cancer 37
12.11 EGFR MDM2 TP53
16
p53 Signaling 64
Show member pathways
 12.07 MDM2 PTEN TP53
17
Cellular senescence (KEGG) 37
11.99 MDM2 PTEN TP53
18
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 11.93 EGFR MDM2 PTEN
19
MAPK Signaling: Mitogen Stimulation Pathway 65
Show member pathways
 11.92 EGFR MDM2 PTEN TP53
20
FoxO signaling pathway 37
Show member pathways
 11.9 EGFR MDM2 PTEN
21
Spinal Cord Injury 1
11.82 EGFR GFAP TP53
22
DNA Damage Response (only ATM dependent) 1
11.78 MDM2 PTEN TP53
23
AKT Signaling Pathway 67
11.78 EGFR MDM2 PTEN TP53
24
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.75 GFAP INA NES
25
Integrated Breast Cancer Pathway 1
11.75 EGFR MDM2 PTEN TP53
26
Signaling by ERBB4 66
Show member pathways
 11.73 EGFR GFAP MDM2
27
Senescence and Autophagy in Cancer 1
11.71 MDM2 PTEN TP53
28
Androgen receptor signaling pathway 1
11.63 EGFR MDM2 PTEN
29
Direct p53 effectors 1
11.58 EGFR MDM2 PTEN TP53
30
Bladder cancer 37 1
11.52 EGFR MDM2 TP53
31
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
11.33 MDM2 TP53
32
Copper homeostasis 1
11.31 MDM2 PTEN TP53
33
Glioblastoma Multiforme 64
11.3 EGFR MDM2 PTEN TP53
34
Ovarian tumor domain proteases 66
11.24 PTEN TP53
35
Integrated Cancer Pathway 1
11.21 MDM2 PTEN TP53
36
Gastric Cancer Network 2 1
11.18 EGFR TP53
37
Oncogene Induced Senescence 66
11.16 MDM2 TP53
38
Aurora A signaling 1
11.13 MDM2 TP53
39
Inhibition of Ribosome Biogenesis by p14(ARF) 64
10.97 MDM2 TP53
40
TP53 Network 1
Show member pathways
 10.97 MDM2 TP53
41
Central carbon metabolism in cancer 37
10.74 EGFR IDH1 PTEN TP53
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GO Terms for Gliomatosis Cerebri

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Cellular components related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.33 GFAP INA NES
2 neurofilament GO:0005883 8.96 GFAP INA
3 intermediate filament cytoskeleton GO:0045111 8.8 GFAP INA NES

Biological processes related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.67 EGFR MDM2 PTEN TP53
2 protein deubiquitination GO:0016579 9.65 MDM2 PTEN TP53
3 long-term synaptic potentiation GO:0060291 9.49 GFAP PTEN
4 response to antibiotic GO:0046677 9.46 MDM2 TP53
5 response to steroid hormone GO:0048545 9.43 IDH1 MDM2
6 response to organic cyclic compound GO:0014070 9.43 EGFR IDH1 PTEN
7 cellular response to gamma radiation GO:0071480 9.4 MDM2 TP53
8 cellular response to hypoxia GO:0071456 9.33 MDM2 PTEN TP53
9 positive regulation of protein export from nucleus GO:0046827 9.32 MDM2 TP53
10 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.96 EGFR TP53
11 cellular response to actinomycin D GO:0072717 8.62 MDM2 TP53

Molecular functions related to Gliomatosis Cerebri according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.43 EGFR MDM2 TP53
2 enzyme binding GO:0019899 9.26 EGFR MDM2 PTEN TP53
3 disordered domain specific binding GO:0097718 9.16 MDM2 TP53
4 identical protein binding GO:0042802 9.1 EGFR GFAP IDH1 MDM2 PTEN TP53
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Sources for Gliomatosis Cerebri

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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