MCID: GLM044
MIFTS: 31

Glomerular Disease

Categories: Nephrological diseases, Rare diseases
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Aliases & Classifications for Glomerular Disease

Summaries for Glomerular Disease

MalaCards based summary: Glomerular Disease is related to iga glomerulonephritis and focal segmental glomerulosclerosis. An important gene associated with Glomerular Disease is MIR30A (MicroRNA 30a). The drugs Prednisone and Atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and bone marrow.

Related Diseases for Glomerular Disease

Diseases related to Glomerular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 261)
# Related Disease Score Top Affiliating Genes
1 iga glomerulonephritis 30.6 MIR30A CD2AP
2 focal segmental glomerulosclerosis 30.5 MIR30A CD2AP
3 genetic glomerular disease 11.2
4 membranous nephropathy 11.1
5 membranoproliferative glomerulonephritis 11.1
6 focal segmental glomerulosclerosis 10 11.1
7 fibrillary glomerulonephritis 11.0
8 immunotactoid glomerulopathy 11.0
9 collagen type iii glomerulopathy 11.0
10 glomerulopathy with fibronectin deposits 2 10.9
11 epilepsy, progressive myoclonic, 4, with or without renal failure 10.9
12 pierson syndrome 10.9
13 autoimmune interstitial lung, joint, and kidney disease 10.9
14 galloway-mowat syndrome 6 10.9
15 immunotactoid or fibrillary glomerulopathy 10.9
16 congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunization 10.9
17 non-amyloid monoclonal immunoglobulin deposition disease 10.9
18 glomerulonephritis 10.8
19 nephrotic syndrome 10.7
20 iga nephropathy 1 10.7
21 systemic lupus erythematosus 10.6
22 lipoid nephrosis 10.6
23 microvascular complications of diabetes 1 10.5
24 microvascular complications of diabetes 2 10.5
25 microvascular complications of diabetes 3 10.5
26 microvascular complications of diabetes 4 10.5
27 microvascular complications of diabetes 5 10.5
28 microvascular complications of diabetes 6 10.5
29 microvascular complications of diabetes 7 10.5
30 end stage renal disease 10.4
31 proliferative glomerulonephritis 10.4
32 amyloidosis 10.4
33 mesangial proliferative glomerulonephritis 10.4
34 chronic kidney disease 10.3
35 vasculitis 10.3
36 kidney disease 10.3
37 crescentic glomerulonephritis 10.3
38 alport syndrome 10.2
39 purpura 10.2
40 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.2
41 henoch-schoenlein purpura 10.2
42 hemolytic-uremic syndrome 10.2
43 hepatitis c 10.2
44 cryoglobulinemia 10.2
45 wilms tumor 1 10.1
46 hemolytic uremic syndrome, atypical 1 10.1
47 wilms tumor 5 10.1
48 lupus erythematosus 10.1
49 c3 glomerulopathy 10.1
50 autoimmune disease 10.1

Graphical network of the top 20 diseases related to Glomerular Disease:



Diseases related to Glomerular Disease

Symptoms & Phenotypes for Glomerular Disease

Drugs & Therapeutics for Glomerular Disease

Drugs for Glomerular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Atorvastatin Approved Phase 4 134523-00-5 60823
3 Hormones Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 Hormone Antagonists Phase 4
6 glucocorticoids Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Antimetabolites Phase 4
9 Hypolipidemic Agents Phase 4
10 Anticholesteremic Agents Phase 4
11 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
12 Lipid Regulating Agents Phase 4
13
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5282411
14
Beraprost Investigational Phase 2, Phase 3 88430-50-6 2352 5282428
15
Tezosentan Investigational Phase 2, Phase 3 180384-57-0
16 Antihypertensive Agents Phase 2, Phase 3
17 Vasodilator Agents Phase 2, Phase 3
18 Platelet Aggregation Inhibitors Phase 2, Phase 3
19
Rituximab Approved Phase 2 174722-31-7
20
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
21
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
22
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 2 133585-56-5, 60-18-4, 556-02-5 1153 6057
23 Antirheumatic Agents Phase 2
24 Anti-Infective Agents Phase 2
25 Calcineurin Inhibitors Phase 2
26 Cyclosporins Phase 2
27 Antifungal Agents Phase 2
28 Immunosuppressive Agents Phase 2
29 Antineoplastic Agents, Immunological Phase 2
30 Dermatologic Agents Phase 2
31 Immunoglobulins, Intravenous Phase 2
32 Immunoglobulins Phase 2
33 Immunoglobulin A Phase 2
34 Antibodies Phase 2
35 Immunologic Factors Phase 2
36
Prednisolone phosphate Approved, Vet_approved 302-25-0
37
Prednisolone acetate Approved, Vet_approved 52-21-1
38
Prednisolone Approved, Vet_approved 50-24-8 4894 5755
39
Methylprednisolone hemisuccinate Approved 2921-57-5 1875
40
Methylprednisolone Approved, Vet_approved 83-43-2 4159 6741
41
Cholecalciferol Approved, Nutraceutical, Vet_approved 67-97-0, 1406-16-2 5280795 10883523
42
Prednisolone hemisuccinate Experimental 2920-86-7 4897
43 Vitamins
44 Trace Elements
45 Calciferol
46 Micronutrients
47 Calcium, Dietary
48 Neuroprotective Agents
49 Antiemetics
50
Methylprednisolone Acetate 584547

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Treatment of Nephrotic Syndrome Relapse With Low Steroid Dose Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
2 The Renal Protective Effects of Low-dose and High-dose Atorvastatin in Patients With Glomerular Disease and Proteinuria: a Randomized Controlled Double Blinded Study Completed NCT00768638 Phase 4 Atorvastatin
3 TRK-100STP PhaseIIb/III Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
5 Rituximab Plus Cyclosporine in Idiopathic Membranous Nephropathy Recruiting NCT00977977 Phase 2 Rituximab Infusion;Oral Cyclosporine
6 A Phase 2, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Safety and Efficacy of ANG-3070 in Patients With Primary Glomerular Disease and Persistent Proteinuria Recruiting NCT04939116 Phase 2 ANG-3070;Placebo
7 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study to Evaluate the Efficacy and Safety of VIS649 in Participants With Immunoglobulin A (IgA) Nephropathy Active, not recruiting NCT04287985 Phase 2 Dose-Placebo;Low Dose-VIS649;Medium Dose-VIS649;High Dose-VIS649
8 Pilot Study: Efficacy and Safety of Vitamin D Supplementation in Glomerular Disease Completed NCT01835639
9 Kidney Disease Biomarkers Completed NCT00255398
10 Pathogenesis of Glomerulosclerosis Completed NCT00001392
11 Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research Recruiting NCT03929887
12 Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia Recruiting NCT04380610
13 The Impact of Glomerular Disorders on Bone Quality and Strength Recruiting NCT04528446
14 Effect of High-dose Glucocorticoids on Markers of Inflammation and Bone Metabolism in Patients With Primary Glomerular Disease Recruiting NCT04987450 Methylprednisolone, prednisone
15 Preparing a Clinical Outcomes Assessment Set for Nephrotic Syndrome Recruiting NCT05505500
16 Effect of Moderate Caloric Restriction on Glomerular Growth After Kidney Transplantation Terminated NCT03607500

Search NIH Clinical Center for Glomerular Disease

Genetic Tests for Glomerular Disease

Anatomical Context for Glomerular Disease

Organs/tissues related to Glomerular Disease:

MalaCards : Kidney, Bone, Bone Marrow, Endothelial, Smooth Muscle, Neutrophil, Myeloid

Publications for Glomerular Disease

Articles related to Glomerular Disease:

(show top 50) (show all 3360)
# Title Authors PMID Year
1
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. 62 46
18776121 2008
2
Ion channels and channelopathies in glomeruli. 62
36007181 2023
3
Integrin α3 negative podocytes: A gene expression study. 62
36060790 2022
4
Evaluation of screening with urine dipsticks and renal ultrasonography for 3-year-olds in Chiba City over 30 years. 62
36056980 2022
5
Skeletal Outcomes in Children and Young Adults with Glomerular Disease. 62
36171052 2022
6
TYRO3 agonist as a novel therapy for glomerular disease. 62
36454644 2022
7
Changes in the spectrum of kidney diseases: a survey of 2803 patients from 2010 to 2018 at a single center in southeastern China. 62
35656734 2022
8
A Population-Based Analysis of the Risk of Glomerular Disease Relapse after COVID-19 Vaccination. 62
36332971 2022
9
TNF-α-mediated podocyte injury via the apoptotic death receptor pathway in a mouse model of IgA nephropathy. 62
35837694 2022
10
Contrast-enhanced ultrasonography for assessing histopathology in pediatric immunoglobulin A nephropathy and Henoch-Schönlein purpura nephritis. 62
35695915 2022
11
The Risk of Cardiovascular Events in Individuals With Primary Glomerular Diseases. 62
35659570 2022
12
The spectrum and changes of biopsy-proven kidney diseases in Chinese children. 62
36472788 2022
13
Epidemiology of biopsy-proven glomerular diseases in Chinese children: A scoping review. 62
36420176 2022
14
Basement membrane defects in CD151-associated glomerular disease. 62
35278129 2022
15
Factor H related proteins modulate complement activation on kidney cells. 62
36063874 2022
16
The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease. 62
36108806 2022
17
Associations between nephron number and podometrics in human kidneys. 62
36175177 2022
18
Current Trends and Challenges in Nephrology Fellowship Training: Expansion of Education in Home Dialysis, Palliative Care, and Point-of-Care Ultrasound. 62
36371114 2022
19
Alternatively Spliced Landscape of PPARγ mRNA in Podocytes Is Distinct from Adipose Tissue. 62
36359851 2022
20
Artificial intelligence in glomerular diseases. 62
35266037 2022
21
An integrated skin cancer education program in renal transplant recipients and patients with glomerular disease. 62
36357857 2022
22
Humoral and cellular responses after a third dose of SARS-CoV-2 mRNA vaccine in patients with glomerular disease. 62
36352472 2022
23
Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 Signaling. 62
36429053 2022
24
Fibronectin glomerulopathy with monoclonal gammopathy responding to bortezomib plus dexamethasone: a case report. 62
36451151 2022
25
Amyloid fibril structure from the vascular variant of systemic AA amyloidosis. 62
36433936 2022
26
A case of juvenile-onset fibrillary glomerulonephritis diagnosed by mass spectrometry and immunohistochemistry of DNAJB9. 62
35199316 2022
27
Immunosuppression Exposure and Risk of Infection-Related Acute Care Events in Patients With Glomerular Disease: An Observational Cohort Study. 62
36339665 2022
28
Anti-glomerular basement membrane glomerulonephritis concurrent with membranous nephropathy and acute tubular interstitial nephritis in a lung cancer patient treated with pembrolizumab. 62
36401746 2022
29
Apixaban Prophylactic Anticoagulation in Patients with Nephrotic Syndrome. 62
36299618 2022
30
Acute chest pain and dyspnoea as clinical presentation of primary membranous nephropathy. A case report and literature review. 62
36300242 2022
31
Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Renal Vasculitis Following COVID-19 Vaccination: A Case Report and Literature Review. 62
36381730 2022
32
Acute kidney injury after Pfizer COVID-19 vaccine due to crescentic fibrillary glomerulonephritis. 62
35900077 2022
33
B cell phenotype, activity, and function in idiopathic nephrotic syndrome. 62
36316536 2022
34
IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome. 62
36269406 2022
35
The role of complement in glomerulonephritis - are novel therapies ready for prime time? 62
36307926 2022
36
Epidemiology and clinicopathological characteristics of native kidney disease in children in Flanders, Belgium. 62
36227435 2022
37
Challenges in Diagnosis and Management of Glomerular Disease in Resource-Limited Settings. 62
36217525 2022
38
Use of Histologic Parameters to Predict Glomerular Disease Progression: Findings From the China Kidney Biopsy Cohort Study. 62
36252881 2022
39
Impact of Early Proteinuria Reduction in Glomerular Disease and Decline of Kidney Function: A Retrospective Cohort. 62
36233832 2022
40
Racial and Ethnic Disparities in Acute Care Utilization Among Patients With Glomerular Disease. 62
36191724 2022
41
Urine Uromodulin Is Not Associated With Blood Pressure in the Chronic Kidney Disease in Children Cohort. 62
35920156 2022
42
Principles of Immunosuppression in the Management of Kidney Disease: Core Curriculum 2022. 62
35440396 2022
43
ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism. 62
36180463 2022
44
An updated view of the pathogenesis of steroid-sensitive nephrotic syndrome. 62
35006356 2022
45
The pathological spectrum of pediatric kidney disease: 18-Year experience from a single tertiary care center in northern Taiwan. 62
36163129 2022
46
Glomerular Hematuria and the Utility of Urine Microscopy: A Review. 62
35777984 2022
47
Kidney thrombotic microangiopathy in lupus nephritis: Impact on treatment and prognosis. 62
35650019 2022
48
Kidney Disease Patterns diagnosed by Kidney Biopsy: A Single-center Experience from Central India. 62
36082883 2022
49
Trends of primary glomerular disease in Turkey: TSN-GOLD registry report. 62
35107695 2022
50
Distribution of pathological types and epidemiological characteristics based on kidney biopsy in Northwest China. 62
36328996 2022

Variations for Glomerular Disease

Expression for Glomerular Disease

Search GEO for disease gene expression data for Glomerular Disease.

Pathways for Glomerular Disease

GO Terms for Glomerular Disease

Sources for Glomerular Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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