MCID: GLM044
MIFTS: 34

Glomerular Disease

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for Glomerular Disease

MalaCards integrated aliases for Glomerular Disease:

Name: Glomerular Disease 58 17

Classifications:

Orphanet: 58  
Rare renal diseases


External Ids:

UMLS via Orphanet 71 C0268731
Orphanet 58 ORPHA93548

Summaries for Glomerular Disease

MalaCards based summary : Glomerular Disease is related to glomerulonephritis and membranoproliferative glomerulonephritis. An important gene associated with Glomerular Disease is MIR30A (MicroRNA 30a), and among its related pathways/superpathways is Nephrin interactions. The drugs Prednisone and Atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are cardiovascular system and immune system

Related Diseases for Glomerular Disease

Diseases related to Glomerular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 31.0 CD79A ALB ACE
2 membranoproliferative glomerulonephritis 30.8 CD79A ALB
3 membranous nephropathy 30.6 CD79A CD2AP ALB ACE
4 microvascular complications of diabetes 3 30.5 NAGLU ALB ACE
5 purpura 30.4 CD79A ACE
6 iga glomerulonephritis 30.3 NAGLU MIR30A CD79A CD2AP ALB ACE
7 focal segmental glomerulosclerosis 30.2 CD2AP ALB ACTN4 ACE
8 idiopathic nephrotic syndrome 30.2 ALB ACE
9 arteriolosclerosis 29.8 CD79A ALB
10 interstitial nephritis 29.8 ALB ACE
11 acute poststreptococcal glomerulonephritis 29.8 CD79A ALB
12 nephrotic syndrome, type 1 29.8 CD2AP ACTN4
13 familial nephrotic syndrome 29.8 CD2AP ALB ACTN4
14 focal segmental glomerulosclerosis 1 29.7 CD2AP ACTN4
15 end stage renal disease 29.7 CD2AP ALB ACTN4 ACE
16 anuria 29.7 ALB ACE
17 denys-drash syndrome 29.6 CD2AP ACTN4
18 nephrotic syndrome, type 2 29.6 CD2AP ACTN4
19 proteinuria, chronic benign 29.6 NAGLU CD79A CD2AP ALB ACTN4 ACE
20 acute kidney tubular necrosis 29.6 NAGLU ALB ACE
21 autosomal dominant polycystic kidney disease 29.5 CD79A ALB ACE
22 exanthem 29.5 ALB ACE
23 nephrotic syndrome 29.5 NAGLU CD79A CD2AP ALB ACTN4 ACE
24 nail-patella syndrome 29.5 CD2AP ACTN4
25 alport syndrome 29.4 CD2AP ALB ACTN4 ACE
26 henoch-schoenlein purpura 29.4 CD79A ALB ACE
27 hypertensive nephropathy 29.3 NAGLU ALB ACE
28 vesicoureteral reflux 1 29.3 NAGLU ALB ACE
29 kidney disease 28.8 NAGLU CD79A CD2AP ALB ACTN4 ACE
30 systemic lupus erythematosus 28.6 MIR30A CD79A ALB ACTN4 ACE
31 lipoid nephrosis 28.5 NAGLU CD79A CD2AP ALB ACTN4
32 genetic glomerular disease 11.2
33 loin pain hematuria syndrome 11.0
34 fibrillary glomerulonephritis 10.9
35 immunotactoid glomerulopathy 10.9
36 glomerulopathy with fibronectin deposits 2 10.9
37 galloway-mowat syndrome 6 10.9
38 nephronophthisis 10.9
39 immunotactoid or fibrillary glomerulopathy 10.9
40 microvascular complications of diabetes 4 10.5
41 microvascular complications of diabetes 6 10.5
42 microvascular complications of diabetes 7 10.5
43 proliferative glomerulonephritis 10.4
44 amyloidosis 10.4
45 vasculitis 10.3
46 mesangial proliferative glomerulonephritis 10.3
47 crescentic glomerulonephritis 10.3
48 chronic kidney disease 10.3
49 root caries 10.2 CD79A ALB
50 pleural empyema 10.2 CD79A ALB

Graphical network of the top 20 diseases related to Glomerular Disease:



Diseases related to Glomerular Disease

Symptoms & Phenotypes for Glomerular Disease

MGI Mouse Phenotypes related to Glomerular Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 ACE ACTN4 ALB CD2AP KLF15 NAGLU
2 immune system MP:0005387 9.7 ACE ACTN4 ALB CD2AP CD79A KLF15
3 liver/biliary system MP:0005370 9.43 ACE ACTN4 ALB CD79A KLF15 NAGLU
4 renal/urinary system MP:0005367 9.17 ACE ACTN4 ALB CD2AP CD79A KLF15

Drugs & Therapeutics for Glomerular Disease

Drugs for Glomerular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Atorvastatin Approved Phase 4 134523-00-5 60823
3 Hormone Antagonists Phase 4
4 glucocorticoids Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antineoplastic Agents, Hormonal Phase 4
7 Anticholesteremic Agents Phase 4
8 Antimetabolites Phase 4
9 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
10 Hypolipidemic Agents Phase 4
11 Lipid Regulating Agents Phase 4
12
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5280427 5282411
13 Beraprost Investigational Phase 2, Phase 3 88430-50-6
14
Tezosentan Investigational Phase 2, Phase 3 180384-57-0
15 Antihypertensive Agents Phase 2, Phase 3
16 Vasodilator Agents Phase 2, Phase 3
17 Platelet Aggregation Inhibitors Phase 2, Phase 3
18
Atrasentan Investigational Phase 2 173937-91-2, 195733-43-8 159594
19 Endothelin A Receptor Antagonists Phase 2
20 Endothelin Receptor Antagonists Phase 2
21
rituximab Approved 174722-31-7 10201696
22
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
23
Vitamin D3 Approved, Nutraceutical 67-97-0 6221 5280795
24
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
25 Hormones
26 Micronutrients
27 Trace Elements
28 Nutrients
29 Vitamins
30 Calciferol
31 Calcium, Dietary
32 Angiotensin-Converting Enzyme Inhibitors
33 Immunoglobulin A
34 Immunoglobulins
35 Immunoglobulins, Intravenous
36 Antibodies
37
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Treatment of Nephrotic Syndrome Relapse With Low Steroid Dose Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
2 The Renal Protective Effects of Low-dose and High-dose Atorvastatin in Patients With Glomerular Disease and Proteinuria: a Randomized Controlled Double Blinded Study Completed NCT00768638 Phase 4 Atorvastatin;Atorvastatin
3 TRK-100STP PhaseIIb/III Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
4 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
5 A Phase 2, Open-Label, Basket Study of Atrasentan in Patients With Proteinuric Glomerular Diseases Recruiting NCT04573920 Phase 2 Atrasentan
6 Pathogenesis of Glomerulosclerosis Completed NCT00001392
7 Pilot Study: Efficacy and Safety of Vitamin D Supplementation in Glomerular Disease Completed NCT01835639
8 Nephrologic Intervention in Patients Waiting for Cardiac Surgery Completed NCT02643745
9 The Impact of Glomerular Disorders on Bone Quality and Strength Recruiting NCT04528446
10 Multicenter Prospective Cohort of Kidney Biopsy for Glomerular Disease Research Recruiting NCT03929887
11 Human Urine Sample Collection for Alport Nephropathy Biomarker Studies Terminated NCT01602835

Search NIH Clinical Center for Glomerular Disease

Genetic Tests for Glomerular Disease

Anatomical Context for Glomerular Disease

MalaCards organs/tissues related to Glomerular Disease:

40
Kidney, Endothelial, Bone, Neutrophil, Monocytes, Bone Marrow, Smooth Muscle

Publications for Glomerular Disease

Articles related to Glomerular Disease:

(show top 50) (show all 3046)
# Title Authors PMID Year
1
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. 61 47
18776121 2008
2
Critically ill, tubular injury, delayed early recovery: characteristics of acute kidney disease with renal oxalosis. 61
33663319 2021
3
DNA J homolog subfamily B member 9 and other advances in fibrillary glomerulonephritis. 61
33767057 2021
4
Differential expression analysis of urinary exosomal circular RNAs in patients with IgA nephropathy. 61
33501721 2021
5
Health-related quality of life in children with chronic kidney disease is affected by the number of medications. 61
33547529 2021
6
Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients. 61
33044675 2021
7
Towards Modelling Genetic Kidney Diseases with Human Pluripotent Stem Cells. 61
33774632 2021
8
Disruption of pathways regulated by Integrator complex in Galloway-Mowat syndrome due to WDR73 mutations. 61
33686175 2021
9
Deficiency of mitochondrial glycerol 3-phosphate dehydrogenase exacerbates podocyte injury and the progression of diabetic kidney disease. 61
33741719 2021
10
Calpastatin prevents Angiotensin II-mediated podocyte injury through maintenance of autophagy. 61
33675847 2021
11
Complete remission of DnaJ homolog subfamily B member 9-positive fibrillary glomerulonephritis following steroid monotherapy in an elderly Japanese woman. 61
33656648 2021
12
Rapidly progressive IgA vasculitis-associated nephritis successfully treated with immunosuppressive therapy in an adolescent with chronic granulomatous disease. 61
33683583 2021
13
Urinary Extracellular Vesicle Protein Profiles Discriminate Different Clinical Subgroups of Children with Idiopathic Nephrotic Syndrome. 61
33800879 2021
14
Renal Disease in Primary Sjögren's Syndrome. 61
33367966 2021
15
Sickle cell nephropathy. Clinical manifestations and new mechanisms involved in kidney injury. 61
33714630 2021
16
Disparate roles of retinoic acid signaling molecules in kidney disease. 61
33645319 2021
17
Generation of the induced pluripotent stem cell line (NCKDi002-A) from a 22-year-old patient with Focal Segmental Glomerular Sclerosis carrying a heterozygous mutation in WT1 gene. 61
33780729 2021
18
A pediatric gateway initiative for glomerular disease: introducing PIONEER. 61
33637196 2021
19
Nuclear receptors in podocyte biology and glomerular disease. 61
32943753 2021
20
Correction: Infection-Related Acute Care Events among Patients with Glomerular Disease. 61
33648975 2021
21
Podocyte Autophagy in Homeostasis and Disease. 61
33809036 2021
22
Association of Obesity with Cardiovascular Risk Factors and Kidney Disease Outcomes in Primary Proteinuric Glomerulopathies. 61
33677435 2021
23
Metformin ameliorates the severity of experimental Alport syndrome. 61
33782421 2021
24
Selective endothelin A receptor antagonism in patients with proteinuric chronic kidney disease. 61
33356648 2021
25
GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid-Sensitive Nephrotic Syndrome. 61
32680915 2021
26
Circulating plasmablasts and high level of BAFF are hallmarks of minimal change nephrotic syndrome in adults. 61
33241414 2021
27
Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis. 61
33203894 2021
28
MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes. 61
33144214 2021
29
Rituximab in treatment of collapsing FSGS-A case series. 61
32662534 2021
30
Serological screening for COVID-19 in patients with glomerular disease. 61
33615050 2021
31
Recovery of Kidney Function Among Patients With Glomerular Disease Starting Maintenance Dialysis. 61
32771649 2021
32
TrkC Is Essential for Nephron Function and Trans-Activates Igf1R Signaling. 61
33380522 2021
33
Human reconstructed kidney models. 61
33594607 2021
34
Pathogenesis of diabesity-induced kidney disease: role of kidney nutrient sensing. 61
33630415 2021
35
Management of Anticoagulant-Related Nephropathy: A Single Center Experience. 61
33669373 2021
36
Systolic blood pressure and chronic kidney disease progression in patients with primary glomerular disease. 61
33555575 2021
37
The role of extracellular vesicles in podocyte autophagy in kidney disease. 61
33619681 2021
38
Glomerular podocyte dysfunction in inherited renal tubular disease. 61
33625696 2021
39
Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease. 61
33099633 2021
40
A Systematic Review of Immune Checkpoint Inhibitor-Associated Glomerular Disease. 61
33426386 2021
41
CD80 Insights as Therapeutic Target in the Current and Future Treatment Options of Frequent-Relapse Minimal Change Disease. 61
33506028 2021
42
COVID-19-Associated Glomerular Disease. 61
33214201 2021
43
A review of nephrotic syndrome and atopic diseases in children. 61
33532335 2021
44
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective. 61
33494099 2021
45
Social Determinants of Cardiovascular Health in African American Children With CKD: An Analysis of the Chronic Kidney Disease in Children (CKiD) Study. 61
33418013 2021
46
Epigenome-wide association study and network analysis for IgA Nephropathy from CD19+ B-cell in Chinese Population. 61
33319642 2021
47
Subfertility and early menopause in women with glomerular disease. 61
33508104 2021
48
NPHS2 gene polymorphism aggravates renal damage caused by focal segmental glomerulosclerosis with COL4A3 mutation. 61
33305316 2021
49
Results from the IRoc-GN international registry of patients with COVID-19 and glomerular disease suggest close monitoring. 61
33181156 2021
50
Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature. 61
33762816 2021

Variations for Glomerular Disease

Expression for Glomerular Disease

Search GEO for disease gene expression data for Glomerular Disease.

Pathways for Glomerular Disease

Pathways related to Glomerular Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.97 CD2AP ACTN4

GO Terms for Glomerular Disease

Sources for Glomerular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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