MCID: GLM001
MIFTS: 32

Glomeruloid Hemangioma

Categories: Cancer diseases, Cardiovascular diseases

Aliases & Classifications for Glomeruloid Hemangioma

MalaCards integrated aliases for Glomeruloid Hemangioma:

Name: Glomeruloid Hemangioma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:486
NCIt 49 C27505
SNOMED-CT 67 403976007
UMLS 71 C1304511

Summaries for Glomeruloid Hemangioma

MalaCards based summary : Glomeruloid Hemangioma is related to poems syndrome and hemangioma. An important gene associated with Glomeruloid Hemangioma is MYOM2 (Myomesin 2), and among its related pathways/superpathways are NF-kappaB Signaling and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include skin and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Glomeruloid hemangioma is a distinctive vascular tumor first described in 1990 when found to be... more...

Related Diseases for Glomeruloid Hemangioma

Diseases related to Glomeruloid Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 332)
# Related Disease Score Top Affiliating Genes
1 poems syndrome 30.7 VEGFA MYOM2 IL6 IL1B
2 hemangioma 30.3 VEGFA PECAM1 FLT1 ENG CD68 CD34
3 capillary hemangioma 30.0 VEGFA PECAM1 FLT1 CD34
4 polyneuropathy 30.0 VEGFA IL6 IL1B
5 plasmacytoma 29.9 VEGFA PTPRC IL6
6 plasma cell neoplasm 29.4 SDC1 PTPRC MYOM2 IL6
7 thrombocytopenia 29.1 PECAM1 IL6 IL1B ENG CD34
8 myeloma, multiple 27.5 VEGFA SDC1 PTPRC MYOM2 IL6 IL1B
9 glomangioma 10.5 PECAM1 CD34
10 skin epithelioid hemangioma 10.5 PECAM1 CD34
11 aortic malignant tumor 10.5 PECAM1 CD34
12 osteosclerotic myeloma 10.5 VEGFA MYOM2
13 central nervous system angiosarcoma 10.5 PECAM1 CD34
14 intravascular angioleiomyoma 10.5 PECAM1 CD34
15 heart fibrosarcoma 10.4 PECAM1 CD34
16 ovarian angiosarcoma 10.4 PECAM1 CD34
17 conventional angiosarcoma 10.4 PECAM1 CD34
18 angiomyoma 10.4 PECAM1 CD34
19 gallbladder leiomyosarcoma 10.4 PECAM1 CD34
20 glomangiosarcoma 10.4 PECAM1 CD34
21 thyroid sarcoma 10.4 PECAM1 CD34
22 liposarcoma of bone 10.4 PECAM1 CD34
23 hemangioma of spleen 10.4 PECAM1 CD34
24 radiation proctitis 10.4 VEGFA PECAM1
25 kaposiform hemangioendothelioma 10.4 PECAM1 CD34
26 liver leiomyoma 10.4 PECAM1 CD34
27 benign perivascular tumor 10.4 PECAM1 CD34
28 intramuscular hemangioma 10.4 PECAM1 CD34
29 colonic lymphangioma 10.4 PECAM1 CD34
30 hobnail hemangioma 10.4 PECAM1 CD34
31 breast hemangioma 10.4 PECAM1 CD34
32 erythema elevatum diutinum 10.4 PECAM1 CD34
33 heart sarcoma 10.4 PECAM1 CD34
34 benign mesothelioma 10.4 PECAM1 CD34
35 vulvar leiomyoma 10.4 PECAM1 CD34
36 middle ear adenocarcinoma 10.4 PECAM1 CD68
37 histiocytoid hemangioma 10.4 PECAM1 CD34
38 thyroid angiosarcoma 10.4 PECAM1 CD34
39 angiolipoma 10.4 PECAM1 CD34
40 malignant granular cell myoblastoma 10.4 CD68 CD34
41 breast sarcoma 10.4 PECAM1 CD34
42 peliosis hepatis 10.4 VEGFA CD34
43 liver sarcoma 10.4 CD68 CD34
44 chondroid lipoma 10.4 CD68 CD34
45 pleomorphic lipoma 10.4 CD68 CD34
46 microcystic meningioma 10.4 VEGFA FLT1
47 streptococcal toxic-shock syndrome 10.3 MYOM2 IL6
48 extraosseous osteosarcoma 10.3 CD68 CD34
49 infiltrating angiolipoma 10.3 VEGFA CD34
50 subungual glomus tumor 10.3 PECAM1 CD34

Graphical network of the top 20 diseases related to Glomeruloid Hemangioma:



Diseases related to Glomeruloid Hemangioma

Symptoms & Phenotypes for Glomeruloid Hemangioma

MGI Mouse Phenotypes related to Glomeruloid Hemangioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 CD34 CD68 ENG FLT1 IL1B IL6
2 homeostasis/metabolism MP:0005376 9.96 CD34 ENG FLT1 IL1B IL6 PECAM1
3 immune system MP:0005387 9.85 CD34 CD68 FLT1 IL1B IL6 PECAM1
4 integument MP:0010771 9.56 CD34 ENG IL1B IL6 PRL PTPRC
5 neoplasm MP:0002006 9.17 CD34 IL1B IL6 PRL PTPRC SDC1

Drugs & Therapeutics for Glomeruloid Hemangioma

Search Clinical Trials , NIH Clinical Center for Glomeruloid Hemangioma

Genetic Tests for Glomeruloid Hemangioma

Anatomical Context for Glomeruloid Hemangioma

MalaCards organs/tissues related to Glomeruloid Hemangioma:

40
Skin, Endothelial

Publications for Glomeruloid Hemangioma

Articles related to Glomeruloid Hemangioma:

(show all 27)
# Title Authors PMID Year
1
Papillary Hemangioma: An Under-Recognized Entity Not to Be Confused With Glomeruloid Hemangioma. 61
31592865 2020
2
Tufted-angioma-like lesion associated with vascular endothelial growth factor and interleukin-6 in TAFRO syndrome: Is it a common histological feature of multicentric Castleman disease/POEMS syndrome? 61
30632181 2019
3
Glomeruloid hemangioma associated with TAFRO syndrome. 61
29702119 2018
4
Glomeruloid Hemangioma as a Late Manifestation of POEMS Syndrome. 61
30665482 2018
5
Cutaneous Glomeruloid Hemangioma: A Report on Two Cases and a Review of Literature. 61
28813760 2017
6
Glomeruloid Hemangioma as a Marker for the Early Diagnosis of POEMS Syndrome. 61
28392663 2017
7
Glomeruloid hemangioma and POEMS syndrome. 61
27208909 2017
8
Contributions of Dr. Juan Rosai to the pathology of cutaneous vascular proliferations: A review of selected lesions. 61
27318413 2016
9
Glomeruloid hemangioma in normal individuals. 61
23716835 2013
10
Uterine glomeruloid hemangioma in a patient without POEMS syndrome. 61
22134630 2012
11
Glomeruloid hemangioma in POEMS syndrome: a report on two cases and a review of the literature. 61
22281906 2011
12
Glomeruloid hemangioma as a very early presenting sign of POEMS syndrome. 61
19614998 2009
13
[POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case]. 61
19701559 2009
14
Eosinophilic globules in 3 cases of glomeruloid hemangioma of the head and neck: a characteristic offering more evidence for thanatosomes with or without POEMS. 61
19033925 2008
15
Glomeruloid hemangioma. 61
18477219 2008
16
Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma. 61
16860182 2006
17
Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome. 61
16781311 2006
18
Vascular tumors of the skin: a selective review. 61
15912727 2004
19
Reactive angioendotheliomatosis of the intestine. 61
15043317 2004
20
Glomeruloid hemangioma--a specific cutaneous marker of POEMS syndrome. 61
11589746 2001
21
Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells. 61
10678704 2000
22
Endovascular papillary angioendothelioma (Dabska tumor) 61
9788271 1998
23
A case of glomeruloid hemangioma associated with multicentric Castleman's disease. 61
9650700 1998
24
Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms. 61
9418757 1997
25
Glomeruloid hemangioma. A cutaneous marker of POEMS syndrome. 61
8030771 1994
26
Acquired benign and "borderline" vascular lesions. 61
1730175 1992
27
Glomeruloid hemangioma. A distinctive cutaneous lesion of multicentric Castleman's disease associated with POEMS syndrome. 61
2173428 1990

Variations for Glomeruloid Hemangioma

Expression for Glomeruloid Hemangioma

Search GEO for disease gene expression data for Glomeruloid Hemangioma.

Pathways for Glomeruloid Hemangioma

Pathways related to Glomeruloid Hemangioma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.31 PTPRC PECAM1 IL1B CD34
2 11.97 VEGFA IL6 IL1B
3 11.88 SDC1 PTPRC PECAM1 CD34
4 11.81 VEGFA SDC1 PECAM1 IL1B
5 11.79 VEGFA IL6 IL1B
6 11.76 VEGFA IL6 FLT1
7 11.7 VEGFA IL6 IL1B
8 11.68 IL6 IL1B CD34
9 11.6 PECAM1 FLT1 ENG
10 11.59 VEGFA IL6 IL1B FLT1
11 11.54 PTPRC IL1B CD34
12 11.43 PTPRC IL6 IL1B CD34
13
Show member pathways
11.41 VEGFA IL6 IL1B
14 11.33 SDC1 PTPRC IL6 ENG CD34
15 11.16 SDC1 PECAM1 IL6 IL1B
16 11.16 SDC1 PTPRC IL6 ENG CD68 CD34
17
Show member pathways
10.78 VEGFA FLT1
18 10.77 IL1B CD68
19 10.62 IL6 IL1B

GO Terms for Glomeruloid Hemangioma

Cellular components related to Glomeruloid Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.87 VEGFA SDC1 PRL IL6 IL1B FLT1
2 extracellular space GO:0005615 9.7 VEGFA PRL PECAM1 IL6 IL1B FLT1
3 cell surface GO:0009986 9.65 VEGFA SDC1 PTPRC ENG CD34
4 cell periphery GO:0071944 9.13 PTPRC PECAM1 CD34
5 external side of plasma membrane GO:0009897 9.02 SDC1 PTPRC PECAM1 ENG CD34

Biological processes related to Glomeruloid Hemangioma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 VEGFA PRL IL6 IL1B FLT1
2 cytokine-mediated signaling pathway GO:0019221 9.86 VEGFA SDC1 IL6 IL1B
3 positive regulation of gene expression GO:0010628 9.85 VEGFA IL6 IL1B ENG CD34
4 angiogenesis GO:0001525 9.84 VEGFA PECAM1 FLT1 ENG
5 positive regulation of cell migration GO:0030335 9.81 VEGFA PECAM1 IL1B FLT1
6 positive regulation of MAPK cascade GO:0043410 9.77 PTPRC IL6 FLT1
7 leukocyte migration GO:0050900 9.73 SDC1 PECAM1 IL1B CD34
8 positive regulation of protein phosphorylation GO:0001934 9.71 VEGFA PECAM1 IL1B ENG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 VEGFA PECAM1 IL6
10 positive regulation of T cell proliferation GO:0042102 9.67 PTPRC IL6 IL1B
11 positive regulation of glial cell proliferation GO:0060252 9.61 IL6 IL1B
12 vascular endothelial growth factor signaling pathway GO:0038084 9.61 VEGFA FLT1
13 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.59 PTPRC IL1B
14 positive regulation of neuroinflammatory response GO:0150078 9.58 IL6 IL1B
15 cardiac muscle fiber development GO:0048739 9.58 VEGFA MYOM2
16 negative regulation of protein autophosphorylation GO:0031953 9.57 PTPRC ENG
17 vascular wound healing GO:0061042 9.55 VEGFA CD34
18 sprouting angiogenesis GO:0002040 9.43 VEGFA FLT1 ENG
19 glomerular endothelium development GO:0072011 9.37 PECAM1 CD34
20 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.33 VEGFA IL1B FLT1
21 positive regulation of T cell mediated immunity GO:0002711 9.32 PTPRC IL1B
22 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.26 VEGFA PTPRC PECAM1 IL6
23 positive regulation of angiogenesis GO:0045766 9.02 VEGFA IL1B FLT1 ENG CD34

Sources for Glomeruloid Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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