Glomerulonephritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GLM007 MIFTS: 62	Glomerulonephritis Categories: Blood diseases, Immune diseases, Nephrological diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Glomerulonephritis

MalaCards integrated aliases for Glomerulonephritis:

Name: Glomerulonephritis ³⁹ ¹² ⁷⁷ ⁵⁴ ⁵⁶ ⁶ ⁴⁵ ¹⁵ ⁷⁴

Bright's Disease ⁵⁴

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Nephrological diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the genitourinary system

Glomerular diseases

Glomerular disorders in diseases classified elsewhere

Unspecified nephritic syndrome

External Ids:

Disease Ontology ¹² DOID:2921

MeSH ⁴⁵ D005921

NCIt ⁵¹ C26784

SNOMED-CT ⁶⁹ 36171008

ICD10 ³⁴ N05 N08

UMLS ⁷⁴ C0017658

Sources

Summaries for Glomerulonephritis

NIH Rare Diseases : ⁵⁴ Glomerulonephritis is a type of kidney disease in which there is inflammation of the glomeruli, the tiny filters that remove excess waste and fluids from the blood. It may be acute or chronic (coming on gradually), and may occur on its own (primary) or be caused by another condition (secondary). Signs and symptoms may depend on the type and cause of the condition and may include blood in the urine; foamy urine; swelling of the face, eyes, or other body parts; abdominal pain; high blood pressure; fatigue; and/or other symptoms. If the condition is severe or prolonged, the kidneys can become damaged. It may be caused by a variety of infections and diseases, and sometimes the cause is unknown. Treatment depends on the cause, type and severity of the condition.

MalaCards based summary : Glomerulonephritis, also known as bright's disease, is related to rapidly progressive glomerulonephritis and crescentic glomerulonephritis. An important gene associated with Glomerulonephritis is CFHR5 (Complement Factor H Related 5), and among its related pathways/superpathways are Innate Immune System and Selenium Micronutrient Network. The drugs Mycophenolic acid and Tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include Kidney, kidney and kidney, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Disease Ontology : ¹² A nephritis that causes inflammation of the glomeruli located in kidney.

Wikipedia : ⁷⁷ Glomerulonephritis (GN) is a term used to refer to several kidney diseases (usually affecting both... more...

Sources

Related Diseases for Glomerulonephritis

Diseases in the Glomerulonephritis family:

Autoimmune Glomerulonephritis

Subacute Glomerulonephritis

Diseases related to Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 708)

#	Related Disease	Score	Top Affiliating Genes
1	rapidly progressive glomerulonephritis	34.1	ICAM1 MPO PRTN3 TGFB1
2	crescentic glomerulonephritis	33.9	CCL2 ICAM1 MPO
3	anti-basement membrane glomerulonephritis	33.9	COL4A3 COL4A5
4	dense deposit disease	33.8	C3 CFH CFHR5
5	immune-complex glomerulonephritis	33.8	C4B CFI ICAM1 MPO
6	proliferative glomerulonephritis	33.7	C3 CCL2 CFH CR1 MPO
7	acute proliferative glomerulonephritis	33.6	CCL2 COL4A3 ICAM1 MPO NPHS1
8	autoimmune glomerulonephritis	33.6	COL4A3 ICAM1 LRP2
9	complement factor h deficiency	33.5	CFH CFI
10	iga glomerulonephritis	33.4	ALB CCL2 CFP NPHS1 TGFB1
11	diffuse glomerulonephritis	33.4	ALB CFP
12	membranoproliferative glomerulonephritis	33.3	ALB C3 C4A CFH CFHR5 CFP
13	goodpasture syndrome	33.3	CFP COL4A3 COL4A5 MPO
14	c3 glomerulopathy	33.1	C3 CFHR5 CFP
15	membranous nephropathy	32.9	ALB C3 LRP2 MPO NPHS1 TGFB1
16	henoch-schoenlein purpura	32.7	C3 ICAM1 MPO
17	lipoid nephrosis	32.3	ALB CCL2 NPHS1
18	systemic lupus erythematosus	31.2	ALB C1QC C3 C4A C4B CCL2
19	lupus erythematosus	31.2	C1QC C3 C4A C4B
20	vasculitis	31.1	CCL2 CFI ICAM1 MPO PRTN3
21	hemolytic-uremic syndrome	30.8	C3 CFH CFHR5 CFI
22	focal segmental glomerulosclerosis	30.8	ALB COL4A3 COL4A5 NPHS1 TGFB1
23	rheumatoid arthritis	30.7	CCL2 CSF1 ICAM1 PRTN3 TGFB1
24	anca-associated vasculitis	30.4	MPO PRTN3
25	subacute bacterial endocarditis	30.4	CFP MPO
26	hemolytic uremic syndrome, atypical 1	30.2	C3 C4B CFH CFHR5 CFI CFP
27	complement deficiency	30.1	C3 C4A CFH CFP
28	nephrosclerosis	30.0	CCL2 NPHS1 TGFB1
29	end stage renal failure	30.0	ALB COL4A5 NPHS1 TGFB1
30	lung disease	30.0	CCL2 MPO PRTN3 TGFB1
31	meningitis	30.0	ALB CCL2 CFP
32	trypanosomiasis	29.9	ALB CCL2 ICAM1
33	kidney disease	29.8	ALB C3 CCL2 CFH COL4A3 COL4A5
34	focal segmental glomerulosclerosis 1	29.8	ICAM1 NPHS1
35	malaria	29.8	ALB CCL2 CR1 ICAM1 TGFB1
36	pleurisy	29.8	CCL2 ICAM1 MPO
37	complement factor i deficiency	29.8	C3 C4B CFI CFP CR1
38	chronic kidney failure	29.7	ALB CFH COL4A5 ICAM1 NPHS1 TGFB1
39	urinary tract obstruction	29.7	ALB CCL2 TGFB1
40	macular degeneration, age-related, 1	29.7	C3 CCL2 CFH CFHR5 CFI
41	peritonitis	29.6	ALB CCL2 ICAM1 MPO
42	hypersensitivity reaction type iii disease	29.3	ALB C3 C4A C4B ICAM1 MPO
43	mesangial proliferative glomerulonephritis	12.5
44	fibrillary glomerulonephritis	12.5
45	pauci-immune glomerulonephritis without anca	12.3
46	acute poststreptococcal glomerulonephritis	12.2
47	non-immunoglobulin-mediated membranoproliferative glomerulonephritis	12.2
48	membranoproliferative glomerulonephritis, x-linked	12.2
49	lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis	12.2
50	pauci-immune glomerulonephritis	12.2

Graphical network of the top 20 diseases related to Glomerulonephritis:

Sources

Symptoms & Phenotypes for Glomerulonephritis

GenomeRNAi Phenotypes related to Glomerulonephritis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.32	ALB C1QC C3 C4A CCL2 COL4A5

MGI Mouse Phenotypes related to Glomerulonephritis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.17	ALB C3 C4B CFH CFI CFP
2	cardiovascular system	MP:0005385	10.14	C3 C4B CFH CFP COL4A3 COL4A5
3	hematopoietic system	MP:0005397	10.11	C3 C4B CFH CFI COL4A5 CSF1
4	immune system	MP:0005387	10.07	C3 C4B CCL2 CFH CFP COL4A3
5	mortality/aging	MP:0010768	9.97	ALB C3 C4B CFH CFP COL4A3
6	renal/urinary system	MP:0005367	9.65	ALB C3 C4B CFH CFI COL4A3
7	vision/eye	MP:0005391	9.23	C3 CFH COL4A3 COL4A5 CSF1 ICAM1

Sources

Drugs & Therapeutics for Glomerulonephritis

Drugs for Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 301)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Mycophenolic acid

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

24280-93-1

446541

Tacrolimus

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

104987-11-3

445643 439492 6473866

Losartan

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

114798-26-4

3961

Angiotensin II

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

68521-88-0, 11128-99-7, 4474-91-3

172198 65143

Candesartan cilexetil

Approved

Phase 4

145040-37-5

2540

Benzocaine

Approved, Investigational

Phase 4,Phase 3,Not Applicable

94-09-7, 1994-09-7

2337

tannic acid

Approved

Phase 4,Phase 3,Not Applicable

1401-55-4

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

83-43-2

6741

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

2921-57-5

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

50-24-8

5755

Enalapril

Approved, Vet_approved

Phase 4,Phase 2,Not Applicable

75847-73-3

5362032 40466924

Enalaprilat

Approved

Phase 4,Phase 2,Not Applicable

76420-72-9

6917719

rituximab

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

174722-31-7

10201696

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2

22916-47-8

4189

Prednisone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

53-03-2

5865

Azathioprine

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

446-86-6

2265

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

6055-19-2, 50-18-0

2907

Ramipril

Approved

Phase 4,Phase 3

87333-19-5

5362129

Probucol

Approved, Investigational

Phase 4

23288-49-5

4912

Valsartan

Approved, Investigational

Phase 4

137862-53-4

60846

Hydroxychloroquine

Approved

Phase 4

118-42-3

3652

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 1,Not Applicable

124-94-7

31307

Bortezomib

Approved, Investigational

Phase 4

179324-69-7

387447 93860

Sirolimus

Approved, Investigational

Phase 4,Phase 2

53123-88-9

46835353 6436030 5284616

Everolimus

Approved

Phase 4,Phase 2

159351-69-6

6442177 70789204

Amoxicillin

Approved, Vet_approved

Phase 4,Not Applicable

26787-78-0

33613

Pentoxifylline

Approved, Investigational

Phase 4,Phase 3,Not Applicable

6493-05-6

4740

Entecavir

Approved, Investigational

Phase 4

142217-69-4

153941

Artesunate

Approved, Investigational

Phase 4

88495-63-0

5464098 6917864

Basiliximab

Approved, Investigational

Phase 4,Phase 2

152923-56-3, 179045-86-4

Adenosine

Approved, Investigational

Phase 4

58-61-7

60961

Calcitriol

Approved, Nutraceutical

Phase 4,Phase 2,Not Applicable

32222-06-3

134070 5280453

Calcium

Approved, Nutraceutical

Phase 4,Phase 3,Phase 2,Not Applicable

7440-70-2

271

Serine

Approved, Nutraceutical

Phase 4,Phase 3,Not Applicable

56-45-1

5951

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Not Applicable

1406-16-2

Ergocalciferol

Approved, Nutraceutical

Phase 4,Phase 3,Not Applicable

50-14-6

5280793

N,N-dimethylarginine

Experimental

Phase 4

30315-93-6

123831

Cilnidipine

Investigational

Phase 4

132203-70-4

5282138

Candesartan

Experimental

Phase 4

139481-59-7

2541

Prednisolone hemisuccinate

Experimental

Phase 4,Phase 3,Phase 2,Not Applicable

2920-86-7

Dexchlorpheniramine

Experimental, Investigational

Phase 4

25523-97-1

33036

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Infective Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunosuppressive Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Immunologic Factors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Antibiotics, Antitubercular

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antitubercular Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Calcineurin Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Antihypertensive Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 391)

#	Name	Status	NCT ID	Phase	Drugs
1	Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG)	Unknown status	NCT00843856	Phase 4	tacrolimus;tacrolimus and mycophenolate mofetil
2	Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis	Unknown status	NCT02063100	Phase 4	Shenyankangfu tablets;Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 100mg;Losartan potassium 100mg
3	Calcitriol in the Treatment of Immunoglobulin A Nephropathy	Unknown status	NCT00862693	Phase 4	Calcitriol
4	A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy	Unknown status	NCT01184599	Phase 4	aliskiren
5	CCB Safety Study in Treatment of Hypertension of ADPKD	Unknown status	NCT00541853	Phase 4	Candesartan;Candesartan and Cilnidipine;Candesartan plus non-CCB agents
6	Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy	Unknown status	NCT02981212	Phase 4	Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
7	Rituximab in Recurrent IgA Nephropathy	Unknown status	NCT02571842	Phase 4	Intravenous Rituximab;ACEI/ARB and corticosteroids
8	Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy	Unknown status	NCT02231125	Phase 4	Losartan;Abelmoschus manihot
9	Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis	Completed	NCT01115426	Phase 4	Ramipril or losartan
10	HSP-glomerulonephritis Trial: MP vs CyA	Completed	NCT00425724	Phase 4	Methylprednisolone pulses plus prednisone versus Cyclosporine A
11	Long-Acting Tacrolimus for the Treatment of Resistant Lupus Nephritis	Completed	NCT01206569	Phase 4	Long-acting tacrolimus (Advagraf, Astellas Pharma)
12	Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy	Completed	NCT00319761	Phase 4	Calcitriol
13	A Study of the Antioxidant Probucol Combined With Valsartan in Patients With IgA Nephropathy	Completed	NCT00426348	Phase 4	Valsartan;Probucol;Placebo
14	Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy: a Self- Controlled Study	Completed	NCT02351752	Phase 4	Hydroxychloroquine Sulfate
15	Mycophenolate Mofetil for IgA Nephropathy	Completed	NCT00863252	Phase 4	mycophenolate mofetil;angiotensin blockade
16	Comparing the Efficacy of Tacrolimus and Mycophenolate Mofetil for the Initial Therapy of Active Lupus Nephritis	Completed	NCT00371319	Phase 4	tacrolimus;mycophenolate mofetil
17	Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effects	Completed	NCT02585804	Phase 4	Dapagliflozin
18	Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children	Completed	NCT01162005	Phase 4	Tacrolimus
19	A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome	Completed	NCT01763580	Phase 4	Tacrolimus;Prednisolone
20	The Effects of Angiotensin II Receptor Blockade on Kidney Function and Scarring After Liver Transplant	Completed	NCT00275639	Phase 4	Cozaar
21	Tacrolimus for the Treatment of Systemic Lupus Erythematosus With Membranous Nephritis	Completed	NCT00125307	Phase 4	tacrolimus
22	Aliskiren for Proteinuric IgAN Despite Angiotensin Blockade	Completed	NCT00922311	Phase 4	Aliskiren
23	"Steroids and Azathioprine Versus Steroids Alone in IgAN"	Completed	NCT00755859	Phase 4	steroids plus azathioprine;steroids
24	Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy	Completed	NCT00498368	Phase 4	Intravenous Rituximab;ACE/ARB
25	To Compare the Efficacy and Safety of Tripterygium Wilfordii (TW) Versus Valsartan in the Membranous Nephropathy (MN)	Completed	NCT00518219	Phase 4	TW
26	Low-dose Combination of Mycophenolate Mofetil (MMF) and Tacrolimus (Tac) for Refractory Lupus Nephritis	Completed	NCT01203709	Phase 4	low dose combination of MMF and Tac
27	Pilot Study of Velcade® in IgA Nephropathy	Completed	NCT01103778	Phase 4	Bortezomib (Velcade®)
28	Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy	Completed	NCT00367562	Phase 4	ENALAPRIL VALSARTAN METHYLPREDNISONE
29	Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients	Completed	NCT01386554	Phase 4	Repository Corticotropin Injection;Placebo
30	Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH	Completed	NCT01155141	Phase 4	H.P. Acthar Gel
31	SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus	Completed	NCT00371826	Phase 4	Everolimus (RAD001);Cyclosporine (Calcineurin Inhibitor (CNI));Methylprednisone/prednisone;Mycophenolate sodium (MPA)
32	Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis	Completed	NCT02645565	Phase 4	Cyclophosphamide;Azathioprine;Methylprednisolone
33	Immunoadsorption in Anti-GBM Glomerulonephritis.	Recruiting	NCT02765789	Phase 4
34	Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN)	Recruiting	NCT03062813	Phase 4	Tacrolimus &entecavir;placebo & entecavir
35	Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy	Recruiting	NCT02765594	Phase 4	Hydroxychloroquine Sulfate;Valsartan
36	Adrenocorticotropic Hormone in Membranous Nephropathy	Recruiting	NCT03025828	Phase 4	ACTHar
37	Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy	Recruiting	NCT03170323	Phase 4	Mycophenolate Mofetil;Cyclosporins
38	Group A Pharyngitis in Children: The GASPARD Study	Recruiting	NCT03264911	Phase 4	Amoxicillin or Placebo
39	Efficacy and Safety of Artesunate Plus Standard of Care in Active Lupus Nephritis	Recruiting	NCT03214731	Phase 4	Artesunate
40	Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis	Recruiting	NCT02630628	Phase 4	Tacrolimus;Mycophenolate mofetil
41	ACTHar in the Treatment of Lupus Nephritis	Recruiting	NCT02226341	Phase 4	CellCept;ACTHar gel;ACTHar gel
42	Treatment of Proteinuria Due to Treatment Resistant or Treatment Intolerant Idiopathic FSGS	Recruiting	NCT02633046	Phase 4	Acthar 80 U 2x/week;Acthar 80 U 3x/week
43	Prevention in Recipients With Primary IgA Nephropathy of Recurrence After Kidney Transplantation: ATG-F Versus Basiliximab as Induction Immunosuppressive Treatment	Active, not recruiting	NCT02523768	Phase 4	ATG-F;Simulect
44	Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy	Active, not recruiting	NCT03218852	Phase 4	prednisone and cyclophosphamide;prednisone alone
45	Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy	Active, not recruiting	NCT01758120	Phase 4	prednisone plus cyclophosphamide;Prednisone alone
46	Effect of Immunosuppression in IgA Nephropathy	Not yet recruiting	NCT03468972	Phase 4	Immunosuppressive treatment
47	Comparative Effectiveness of CEUS Versus DMSA in Renal Scarring Detection	Not yet recruiting	NCT03653702	Phase 4	Lumason
48	Pentoxifylline in Lupus Nephritis	Not yet recruiting	NCT03859570	Phase 4	Pentoxifylline;Placebos
49	Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease	Terminated	NCT01129557	Phase 4	Aliskiren;Valsartan
50	A Study to Evaluate the Efficacy and Safety of Tacrolimus With Steroid in Korean Lupus Nephritis Patients	Terminated	NCT01316133	Phase 4	tacrolimus

Search NIH Clinical Center for Glomerulonephritis

Cell-based therapeutics:

Data from LifeMap, the Embryonic Development and Stem Cells Database

Read about Glomerulonephritis cell therapies at LifeMap Discovery.

Stem-cell-based therapeutic approaches for Glomerulonephritis:

Mesenchymal stromal cells for glomerulonephritis

Embryonic/Adult Cultured Cells Related to Glomerulonephritis:

Bone marrow-derived mesenchymal stromal cells PMIDs: 22172807

Cochrane evidence based reviews: glomerulonephritis

Sources

Genetic Tests for Glomerulonephritis

Sources

Anatomical Context for Glomerulonephritis

The Foundational Model of Anatomy Ontology organs/tissues related to Glomerulonephritis:

²⁰

Kidney

MalaCards organs/tissues related to Glomerulonephritis:

⁴²

Kidney, Neutrophil, T Cells, Liver, Bone, Endothelial, Monocytes

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Glomerulonephritis:

#	Tissue Anatomical CompartmentCell	Relevance
1	Kidney Glomerulus	Affected by disease

Sources

Publications for Glomerulonephritis

Articles related to Glomerulonephritis:

(show top 50) (show all 6266)

#	Title	Authors	Year
1	Role of regulatory T cells in experimental autoimmune glomerulonephritis. ( 30648909 )	Klinge S...Mittr?cker HW	2019
2	Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis. ( 30811635 )	Li Q...Wang Y	2019
3	Anca negative pauci-immune crescentic glomerulonephritis and mixed connective tissue disease: a case study. ( 30897193 )	Fernandes S...Almeida E	2019
4	Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis. ( 30522766 )	Kasinath V...Abdi R	2019
5	Clinical outcomes in patients with biopsy-proved diabetic nephropathy compared to isolated lupus or crescentic glomerulonephritis. ( 30641169 )	Chou YH...Chen YM	2019
6	The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis. ( 30765734 )	Neumann K...Tiegs G	2019
7	Plasmapheresis and corticosteroids in infective endocarditis-related crescentic glomerulonephritis. ( 30872338 )	Malhotra K...Yerram P	2019
8	Role of CD8+ T cells in crescentic glomerulonephritis. ( 30879039 )	Chen A...Schlondorff D	2019
9	Pauci-immune proliferative glomerulonephritis and fungal endocarditis: More than a mere coincidence? ( 30846459 )	Aboud H...Koratala A	2019
10	Infection-Related Glomerulonephritis. ( 30454751 )	Hunt EAK...Somers MJG	2019
11	LncRNAs expression in adriamycin-induced rats reveals the potential role of LncRNAs contributing to chronic glomerulonephritis pathogenesis. ( 30458286 )	Qin XJ...Jiang NN	2019
12	Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy . ( 30474593 )	Sathick IJ...Leung N	2019
13	IgA-Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits. ( 30611830 )	Horino T...Terada Y	2019
14	Small Red Blood Cell Fraction on the UF-1000i Urine Analyzer as a Screening Tool to Detect Dysmorphic Red Blood Cells for Diagnosing Glomerulonephritis. ( 30623619 )	Kim H...Lee HK	2019
15	Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis: A case report. ( 30633192 )	Kataoka H...Nitta K	2019
16	Pneumonia-Associated Acute Glomerulonephritis: Report of 2 Cases. ( 30658555 )	Cascais M...Correia AJ	2019
17	TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions. ( 30662960 )	Kim EY...Dryer SE	2019
18	Changes in primary glomerulonephritis in Singapore over four decades . ( 30663975 )	Woo KT...Foo M	2019
19	Proliferative glomerulonephritis with monoclonal Ig deposits (PGNMID): diagnostic and treatment challenges for the nephrologist! ( 30665574 )	Kousios A...Charif R	2019
20	Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association. ( 30669309 )	Orozco Guill?n AO...Madero M	2019
21	Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report. ( 30683055 )	Kojima T...Oda T	2019
22	Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage. ( 30696480 )	He S...Zuo J	2019
23	Endogenous IL-22 is dispensable for experimental glomerulonephritis. ( 30724106 )	Gnirck AC...Turner JE	2019
24	Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study. ( 30737591 )	Hong Y...Hu W	2019
25	Comparing outcomes of biopsy-proven anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis patients treated with cyclophosphamide in the 20th and 21st centuries: a 23-year study. ( 30746129 )	Whatmough S...Dhaygude A	2019
26	Recurrent proliferative glomerulonephritis with monoclonal immunoglobulin deposits in kidney allografts treated with anti-cd20 antibodies. ( 30747850 )	Buxeda A...Cosio FG	2019
27	Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report. ( 30762802 )	Li X...Ma Z	2019
28	Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft. ( 30764798 )	Von Visger J...Satoskar AA	2019
29	Immune Check Point Inhibitor-Associated Glomerulonephritis. ( 30775635 )	Ashour T...Herlitz L	2019
30	Visceral Leishmaniasis and Glomerulonephritis: A Case Report. ( 30787856 )	Alwazzeh MJ...Alhashimalsayed ZH	2019
31	NPHS2 gene sequencing results in children of the Azerbaijani population with different types of nephrotic syndrome caused by chronic glomerulonephritis. ( 30793612 )	Baylarov R...Haziyev E	2019
32	IgA dominant postinfectious glomerulonephritis secondary to cutaneous infection by methicillin-resistant Staphylococcus aureus. ( 30798997 )	Carbayo J...Mu?oz de Morales A	2019
33	Widening spectrum of renal involvement in psoriasis: First reported case of C3 glomerulonephritis in a psoriatic patient. ( 30804292 )	Balwani MR...Tolani P	2019
34	Chronological change of renal pathological findings in the proliferative glomerulonephritis with monoclonal IgG deposits considered to have recurred early after kidney transplantation. ( 30805792 )	Katsuno T...Maruyama S	2019
35	Metanephric mesenchyme-derived Foxd1+ mesangial precursor cells alleviate mesangial proliferative glomerulonephritis. ( 30810761 )	Jin M...Chen X	2019
36	A patent herbal drug Yi-Shen-Hua-Shi granule ameliorates C-BSA-induced chronic glomerulonephritis and inhabits TGFβ signaling in rats. ( 30836175 )	Zhao J...Yu ZL	2019
37	Concurrent anti-GBM disease and IgA glomerulonephritis. ( 30837085 )	Longano A	2019
38	Clinical course and outcome after kidney transplantation in patients with C3 glomerulonephritis due to CFHR5 nephropathy. ( 30844074 )	Frangou E...Hadjianastassiou V	2019
39	Characteristics of membranoproliferative glomerulonephritis based on a new classification at a single center. ( 30854618 )	Nakano M...Nitta K	2019
40	The histone demethylase LSD1 promotes renal inflammation by mediating TLR4 signaling in hepatitis B virus-associated glomerulonephritis. ( 30894511 )	Yang YT...Yuan WJ	2019
41	Kimura's disease with membranoproliferative glomerulonephritis: a case report with literature review. ( 30912457 )	Su S...Zhang L	2019
42	Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis. ( 30915958 )	Worthing KA...Davies MR	2019
43	Concurrent mucous membrane pemphigoid and membranous glomerulonephritis in a patient with autoantibodies targeting the 1080 region of collagen XVII. ( 30916378 )	Stump M...Fairley JA	2019
44	Poststreptococcal Glomerulonephritis and Antibiotics: A Fresh Look at Old Data. ( 30095005 )	Sainato RJ...Weisse ME	2019
45	Circulating suPAR as a biomarker of disease severity in children with proteinuric glomerulonephritis. ( 27070416 )	So?tysiak J...Ostalska-Nowicka D	2019
46	Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. ( 29290203 )	Rasheed J....Zafar F.	2018
47	Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study. ( 29955611 )	BjA...Fismen A.S.	2018
48	Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )	Huang K....Wei W.	2018
49	Parathyroid Hormone-Related Protein Contributes to Early Healing of Habu Snake Venom-Induced Glomerulonephritis in Mice. ( 29353060 )	Hochane M....Barthelmebs M.	2018
50	18F-FDG PET/CT Imaging of Necrotizing Crescentic Glomerulonephritis With Anti-Glomerular Basement Membrane Disease. ( 29293138 )	Holt E....Chowdhury F.U.	2018

Sources

Genes for Glomerulonephritis

Genes related to Glomerulonephritis (0 elite genes):

(show all 31)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CFHR5	Complement Factor H Related 5	Protein Coding	53.11	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries Variants (show sections)
2	CFH	Complement Factor H	Protein Coding	46.22	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications Variants (show sections)	18371543
3	MPO	Myeloperoxidase	Protein Coding	38.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	7505344 7538261 19238910 (more) 19264905 8082301 17579266 10543328 16624929 2167687 7946512 8909258 11406152 17029081 1336132 10939540 10405206 17365934 10809410 8913096 8189651 7611243 7626983 2172849 7474514 10460948 1721666 1848489 19210866 17060003 15034162 8903866 8281714 12370273 10647949 8059116 1466365 1655091 20155828 15972950 15149327 12743792 10074594 2155342 17699331 15332139 14579943 11816510 9692891 8698399 1848881 1973331 11370121 17108314 16112043 11770797 10456261 9353970 7838242 7933581 8381764 17143091 16769746 16557221 12739838 10227764 8248010 8444414 1663175 9134836 8384653 2200820 16832842 10844589 11034396 14633118
4	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	38.11	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	11490029 9792860 7783419
5	C3	Complement C3	Protein Coding	38.08	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	8018502 18253759 8604713
6	C1QC	Complement C1q C Chain	Protein Coding	37.48	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Summaries (show sections)
7	CFI	Complement Factor I	Protein Coding	35.77	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries (show sections)	16138437 10352206
8	PRTN3	Proteinase 3	Protein Coding	34.03	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders Publications (show sections)	10405206 10844589 11034396 (more) 11092351 8444414 18762796 8381764 17699331 7838242 10456261 12900849 18474117 15149327 1655091
9	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	33.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications Summaries (show sections)	15072851 2129361 7620086
10	ALB	Albumin	Protein Coding	32.8	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	19150611 7940359 9292570 (more) 1965738 1826913 7503148 8190179 19524415 15631343 8671965 17360944 10620205 17497465 1556257 2296344 2115624 18462998 11054356 7619008 10219527 9773777 8050204
11	LRP2	LDL Receptor Related Protein 2	Protein Coding	32.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	2133428 7944157 1495959 (more) 8238258 1280065 10616840 11004703 9727372 9207124 10886254 11145721 7579068 17899086 15800120 10404822 18003776 16775601 10729746 7681839 11132040 16189625 2129462
12	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	31.45	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10469367 7967509 8995729 (more) 8558841 10906168 8587246 19893256 12411099 7645567 12399621 12771503 10657660 15353578 18055544 15634454 10469356 17261994 10708548 9734607 19587833 16126984 1386129
13	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	30.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders (show sections)	1474765
14	C4B	Complement C4B (Chido Blood Group)	Protein Coding	30.85	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
15	C4A	Complement C4A (Rodgers Blood Group)	Protein Coding	30.7	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
16	NPHS1	NPHS1 Adhesion Molecule, Nephrin	Protein Coding	30.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15882266 14633129 11158218 (more) 20237236
17	CFP	Complement Factor Properdin	Protein Coding	30.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8018502 19067130 8604713 (more) 8809142 10354278 7822267
18	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	30.36	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11434169 15751933 8807583 (more) 8050182 9100161 2374609 17173255 17205957 15462102 1407260 12417087 11798960 16303729 18558621 11054345 14758550 1614036 19147994 8016876 8291614 16612332 11728950 8023963 15730046 14726227 12218305 17880921 8983642 11287759
19	CSF1	Colony Stimulating Factor 1	Protein Coding	29.91	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
20	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	29.62	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	1430258 12147094 9274840 (more) 11141473 8094735 9708572 9275482 7752500 1683616 7508348 1753680 1349161 9587631 9014476 20459816 9306956 16509455 12566693 8869290
21	NPHS2	NPHS2 Stomatin Family Member, Podocin	Protein Coding	19.49	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15882266
22	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	19.42	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Disorders (show sections)	9792860
23	C1QB	Complement C1q B Chain	Protein Coding	19.28	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Summaries (show sections)
24	C1S	Complement C1s	Protein Coding	18.92	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
25	CD40LG	CD40 Ligand	Protein Coding	18.52	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11768277 14691923 8604713 (more) 7991037 9008608 19084309 14750122 12552495 2296344
26	IL1B	Interleukin 1 Beta	Protein Coding	18.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11419285 8086312 9263995 (more) 7752582 8455368 17040997 1363752 11233994
27	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	17.95	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	12147094 8869290 7570292 (more) 9275482 8972764 16509455 8675737 9306956
28	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	17.41	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	11792756 10652026 11757824 (more) 11773615 15187193 15577740 18663334 15770393 11782558 11799262 11005620 12480958
29	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	16.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	18497456 10073605
30	CD46	CD46 Molecule	Protein Coding	16.92	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	17914026 8398646 8403504
31	FN1	Fibronectin 1	Protein Coding	16.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8459880 15372454 8122972 (more) 2301387 1544672 9030881

Sources

Variations for Glomerulonephritis

ClinVar genetic disease variations for Glomerulonephritis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	CEL	NM_001807.4(CEL): c.1975G> C (p.Ala659Pro)	single nucleotide variant	Uncertain significance	rs587780309	GRCh37	Chromosome 9, 135946855: 135946855
2	CEL	NM_001807.4(CEL): c.1975G> C (p.Ala659Pro)	single nucleotide variant	Uncertain significance	rs587780309	GRCh38	Chromosome 9, 133071468: 133071468

Copy number variations for Glomerulonephritis from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	21052	1	156500000	165500000	Copy number	FCGR3	Glomerulonephritis
2	21055	1	156500000	165500000	Loss	FCGR3B	Glomerulonephritis
3	21056	1	156500000	165500000	Low copy number	FCGR3B	Glomerulonephritis

Sources

Expression for Glomerulonephritis

Search GEO for disease gene expression data for Glomerulonephritis.

Sources

Pathways for Glomerulonephritis

Pathways related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁷ Show member pathways Immune System ⁶⁷ Neutrophil degranulation ⁶⁷	13.92	C1QC C3 C4A C4B CCL2 CFH
2	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.24	ALB CCL2 CSF1 ICAM1 LRP2 MPO
3	Creation of C4 and C2 activators ⁶⁷ Show member pathways Alternative complement activation ⁶⁷ Classical antibody-mediated complement activation ⁶⁷ Complement cascade ⁶⁷ Ficolins bind to repetitive carbohydrate structures on the target cell surface ⁶⁷ Initial triggering of complement ⁶⁷ Lectin pathway of complement activation ⁶⁷ Terminal pathway of complement ⁶⁷	12.03	C1QC C3 C4A C4B CFH CFI
4	Complement and coagulation cascades ³⁸ ¹	11.94	C1QC C3 C4A C4B CFH CFI
5	AGE-RAGE signaling pathway in diabetic complications ³⁸	11.85	CCL2 COL4A3 COL4A5 ICAM1 TGFB1
6	Interleukin-4 and 13 signaling ⁶⁷	11.82	CCL2 ICAM1 TGFB1
7	TNF signaling pathway ³⁸	11.79	CCL2 CSF1 ICAM1
8	Rheumatoid arthritis ³⁸	11.78	CCL2 CSF1 ICAM1 TGFB1
9	Amoebiasis ³⁸	11.73	COL4A3 COL4A5 TGFB1
10	Complement Pathway ⁶⁵ Show member pathways Alternative Complement Pathway ⁶⁵ Classical Complement Pathway ⁶⁵ Complement Activation ¹ Complement Activation Pathways ⁶⁸ Lectin Induced Complement Pathway ⁶⁵	11.73	C1QC C3 C4A C4B CFH CFP
11	Pertussis ³⁸	11.69	C1QC C3 C4A C4B
12	Immune response Lectin induced complement pathway ²³ Show member pathways Activation of C3 and C5 ⁶⁷ Immune response Alternative complement pathway ²³ Immune response Classical complement pathway ²³ Regulation of Complement cascade ⁶⁷	11.68	C1QC C3 C4A C4B CFH CFI
13	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.67	COL4A3 COL4A5 CR1 NPHS1 TGFB1
14	Malaria ³⁸	11.49	CCL2 CR1 ICAM1 TGFB1
15	Cell adhesion_Plasmin signaling ²³	11.41	COL4A3 COL4A5 TGFB1
16	Interleukin-10 signaling ⁶⁷	11.4	CCL2 CSF1 ICAM1
17	Staphylococcus aureus infection ³⁸	11	C1QC C3 C4A C4B CFH CFI
18	LDL Oxidation in Atherogenesis ⁶⁵	10.87	CCL2 CSF1 ICAM1 MPO
19	G-protein signaling_Rap2B regulation pathway ²³	10.86	CCL2 COL4A3 COL4A5 CSF1 TGFB1

Sources

GO Terms for Glomerulonephritis

Cellular components related to Glomerulonephritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.87	ALB C3 C4A CFP COL4A3 COL4A5
2	extracellular region	GO:0005576	9.86	ALB C1QC C3 C4A C4B CCL2
3	collagen-containing extracellular matrix	GO:0062023	9.8	C1QC CFP COL4A3 COL4A5 ICAM1 PRTN3
4	blood microparticle	GO:0072562	9.7	ALB C1QC C3 C4A C4B CFH
5	azurophil granule lumen	GO:0035578	9.63	C3 MPO PRTN3
6	collagen trimer	GO:0005581	9.61	C1QC COL4A3 COL4A5
7	extracellular space	GO:0005615	9.53	ALB C1QC C3 C4A C4B CCL2
8	collagen type IV trimer	GO:0005587	9.4	COL4A3 COL4A5
9	extracellular exosome	GO:0070062	10.15	ALB C3 C4A C4B CFH CFI

Biological processes related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	9.98	C1QC C3 C4A C4B CFI CFP
2	immune system process	GO:0002376	9.97	C3 C4A C4B CR1 CSF1
3	neutrophil degranulation	GO:0043312	9.92	C3 CFP CR1 MPO PRTN3
4	inflammatory response	GO:0006954	9.88	C3 C4A C4B CCL2 CSF1 TGFB1
5	cytokine-mediated signaling pathway	GO:0019221	9.85	CCL2 CSF1 ICAM1 PRTN3 TGFB1
6	complement activation, classical pathway	GO:0006958	9.85	C1QC C3 C4A C4B CFI CR1
7	innate immune response	GO:0045087	9.81	C1QC C3 C4A C4B CFH CFI
8	cellular protein metabolic process	GO:0044267	9.8	ALB C3 C4A CSF1
9	negative regulation of endopeptidase activity	GO:0010951	9.78	C3 C4A C4B COL4A3
10	complement activation	GO:0006956	9.73	C1QC C3 C4A C4B CFH CFP
11	complement activation, alternative pathway	GO:0006957	9.62	C3 CFH CFHR5 CFP
12	positive regulation of cellular protein metabolic process	GO:0032270	9.58	CSF1 TGFB1
13	regulation of regulatory T cell differentiation	GO:0045589	9.56	CR1 TGFB1
14	negative regulation of phagocytosis	GO:0050765	9.55	PRTN3 TGFB1
15	collagen-activated tyrosine kinase receptor signaling pathway	GO:0038063	9.54	COL4A3 COL4A5
16	glomerular basement membrane development	GO:0032836	9.51	COL4A3 NPHS1
17	regulation of complement activation	GO:0030449	9.28	C1QC C3 C4A C4B CFH CFHR5
18	positive regulation of apoptotic cell clearance	GO:2000427	9.26	C3 C4A C4B CCL2

Molecular functions related to Glomerulonephritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase activity	GO:0004252	9.17	C1QC C3 C4A C4B CFI CFP
2	endopeptidase inhibitor activity	GO:0004866	9.13	C3 C4A C4B

Sources

Sources for Glomerulonephritis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia