MCID: GLM007
MIFTS: 60

Glomerulonephritis

Categories: Blood diseases, Immune diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Glomerulonephritis

MalaCards integrated aliases for Glomerulonephritis:

Name: Glomerulonephritis 38 12 76 53 55 44 15 73
Bright's Disease 53

Classifications:



External Ids:

Disease Ontology 12 DOID:2921
ICD10 33 N05 N08
MeSH 44 D005921
NCIt 50 C26784
SNOMED-CT 68 36171008
UMLS 73 C0017658

Summaries for Glomerulonephritis

NIH Rare Diseases : 53 Glomerulonephritis is a type of kidney disease in which there is inflammation of the glomeruli, the tiny filters that remove excess waste and fluids from the blood. It may be acute or chronic (coming on gradually), and may occur on its own (primary) or be caused by another condition (secondary). Signs and symptoms may depend on the type and cause of the condition and may include blood in the urine; foamy urine; swelling of the face, eyes, or other body parts; abdominal pain; high blood pressure; fatigue; and/or other symptoms. If the condition is severe or prolonged, the kidneys can become damaged. It may be caused by a variety of infections and diseases, and sometimes the cause is unknown. Treatment depends on the cause, type and severity of the condition.

MalaCards based summary : Glomerulonephritis, also known as bright's disease, is related to rapidly progressive glomerulonephritis and acute proliferative glomerulonephritis. An important gene associated with Glomerulonephritis is CFHR5 (Complement Factor H Related 5), and among its related pathways/superpathways are Innate Immune System and Selenium Micronutrient Network. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Kidney, kidney and kidney, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A nephritis that causes inflammation of the glomeruli located in kidney.

Wikipedia : 76 Glomerulonephritis (GN), also known as glomerular nephritis, is a term used to refer to several kidney... more...

Related Diseases for Glomerulonephritis

Diseases in the Glomerulonephritis family:

Autoimmune Glomerulonephritis Subacute Glomerulonephritis

Diseases related to Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 657)
# Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 34.0 MPO PRTN3 TGFB1
2 acute proliferative glomerulonephritis 33.7 CCL2 COL4A3 MPO NPHS1
3 immune-complex glomerulonephritis 33.7 C4B CFI MPO
4 anti-basement membrane glomerulonephritis 33.6 COL4A3 COL4A5
5 dense deposit disease 33.5 C3 CFH CFHR5
6 membranoproliferative glomerulonephritis 33.5 ALB C3 C4A CD79A CFH CFHR5
7 proliferative glomerulonephritis 33.4 C3 CCL2 CD79A CFH CR1 MPO
8 diffuse glomerulonephritis 33.4 ALB CFP
9 iga glomerulonephritis 33.3 ALB CCL2 CD79A CFP NPHS1 TGFB1
10 complement factor h deficiency 33.2 CFH CFI
11 goodpasture syndrome 33.1 CFP COL4A3 COL4A5 MPO
12 c3 glomerulopathy 32.8 C3 CFHR5 CFP
13 membranous nephropathy 32.8 ALB C3 CD79A LRP2 MPO NPHS1
14 alport syndrome, x-linked 32.6 CFHR5 COL4A3 COL4A5
15 henoch-schoenlein purpura 32.2 C3 CD79A MPO
16 lipoid nephrosis 32.1 ALB CCL2 CD79A NPHS1
17 systemic lupus erythematosus 31.3 ALB C1QC C1S C3 C4A C4B
18 vasculitis 31.1 CCL2 CFI MPO PRTN3
19 focal segmental glomerulosclerosis 30.8 ALB COL4A3 COL4A5 NPHS1 TGFB1
20 lupus erythematosus 30.8 C1QC C1S C3 C4A C4B
21 hemolytic-uremic syndrome 30.6 C3 CFH CFHR5 CFI
22 anca-associated vasculitis 30.4 MPO PRTN3
23 subacute bacterial endocarditis 30.2 CFP MPO
24 hemolytic uremic syndrome, atypical 1 30.1 C3 C4B CFH CFHR5 CFI CFP
25 nephrosclerosis 30.0 CCL2 NPHS1 TGFB1
26 kidney disease 30.0 ALB C3 CCL2 CFH COL4A3 COL4A5
27 complement deficiency 30.0 C3 C4A CFH CFP
28 end stage renal failure 29.9 ALB COL4A5 NPHS1 TGFB1
29 chronic kidney failure 29.9 ALB CFH COL4A5 NPHS1 TGFB1
30 meningitis 29.9 ALB CCL2 CFP
31 inflammatory bowel disease 29.8 ALB CCL2 MPO PRTN3 TGFB1
32 lung disease 29.7 CCL2 MPO PRTN3 TGFB1
33 complement factor i deficiency 29.6 C3 C4B CFI CFP CR1
34 arteriolosclerosis 29.6 C3 CD79A
35 chronic graft versus host disease 29.6 ALB CD79A
36 urinary tract obstruction 29.5 ALB CCL2 TGFB1
37 peritonitis 29.5 ALB CCL2 MPO
38 macular degeneration, age-related, 1 29.5 C3 CCL2 CFH CFHR5 CFI
39 hypersensitivity reaction type iii disease 29.3 ALB C3 C4A C4B CD79A MPO
40 mesangial proliferative glomerulonephritis 12.5
41 fibrillary glomerulonephritis 12.4
42 pauci-immune glomerulonephritis without anca 12.2
43 acute poststreptococcal glomerulonephritis 12.2
44 crescentic glomerulonephritis 12.2
45 non-immunoglobulin-mediated membranoproliferative glomerulonephritis 12.2
46 membranoproliferative glomerulonephritis, x-linked 12.2
47 lipodystrophy, partial, acquired, with low complement component c3, with or without glomerulonephritis 12.2
48 pauci-immune glomerulonephritis 12.2
49 subacute glomerulonephritis 12.1
50 autoimmune glomerulonephritis 12.1

Graphical network of the top 20 diseases related to Glomerulonephritis:



Diseases related to Glomerulonephritis

Symptoms & Phenotypes for Glomerulonephritis

GenomeRNAi Phenotypes related to Glomerulonephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.32 ALB C1QC C3 C4A CCL2 CD79A

MGI Mouse Phenotypes related to Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 C3 C4B CD79A CFH CFI COL4A3
2 cardiovascular system MP:0005385 9.97 C3 C4B CFH CFP COL4A3 COL4A5
3 homeostasis/metabolism MP:0005376 9.97 ALB C3 C4B CD79A CFH CFI
4 immune system MP:0005387 9.73 C3 C4B CCL2 CD79A CFH CFP
5 renal/urinary system MP:0005367 9.36 ALB C3 C4B CD79A CFH CFI

Drugs & Therapeutics for Glomerulonephritis

Drugs for Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 284)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
2
Losartan Approved Phase 4,Phase 3,Phase 2,Not Applicable 114798-26-4 3961
3
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
4
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
9
Benzocaine Approved, Investigational Phase 4,Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
10 tannic acid Approved Phase 4,Phase 3,Not Applicable
11
Enalaprilat Approved Phase 4,Phase 2,Not Applicable 76420-72-9 6917719
12
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
13
Enalapril Approved, Vet_approved Phase 4,Phase 2,Not Applicable 75847-73-3 5362032 40466924
14
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
16
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
17
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 446-86-6 2265
18
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 6055-19-2, 50-18-0 2907
19
Ramipril Approved Phase 4,Phase 3 87333-19-5 5362129
20
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
21
Probucol Approved, Investigational Phase 4 23288-49-5 4912
22
Hydroxychloroquine Approved Phase 4 118-42-3 3652
23
Triamcinolone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 124-94-7 31307
24
Bortezomib Approved, Investigational Phase 4 179324-69-7 387447 93860
25
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
26
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 46835353 6436030 5284616
27
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
28
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
29
Artesunate Approved, Investigational Phase 4 88495-63-0 5464098 6917864
30
Basiliximab Approved, Investigational Phase 4,Phase 2 152923-56-3, 179045-86-4
31
Calcitriol Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 32222-06-3 5280453 134070
32
Serine Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 56-45-1 5951
33
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
34
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-14-6 5280793
35
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
36
Cilnidipine Investigational Phase 4 132203-70-4 5282138
37
Candesartan Experimental Phase 4 139481-59-7 2541
38
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Not Applicable 2920-86-7
39
Dexchlorpheniramine Experimental, Investigational Phase 4 25523-97-1 33036
40 Angiotensin Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
41 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 3,Phase 2,Not Applicable
42 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Angiotensinogen Phase 4,Phase 3,Phase 2,Not Applicable
44 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
48 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
49 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable
50 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 382)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis Unknown status NCT02063100 Phase 4 Shenyankangfu tablets;Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 100mg;Losartan potassium 100mg
2 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
3 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
4 CCB Safety Study in Treatment of Hypertension of ADPKD Unknown status NCT00541853 Phase 4 Candesartan;Candesartan and Cilnidipine;Candesartan plus non-CCB agents
5 Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy Unknown status NCT02981212 Phase 4 Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
6 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
7 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
8 Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis Completed NCT01115426 Phase 4 Ramipril or losartan
9 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
10 Long-Acting Tacrolimus for the Treatment of Resistant Lupus Nephritis Completed NCT01206569 Phase 4 Long-acting tacrolimus (Advagraf, Astellas Pharma)
11 Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy Completed NCT00319761 Phase 4 Calcitriol
12 A Study of the Antioxidant Probucol Combined With Valsartan in Patients With IgA Nephropathy Completed NCT00426348 Phase 4 Valsartan;Probucol;Placebo
13 Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy: a Self- Controlled Study Completed NCT02351752 Phase 4 Hydroxychloroquine Sulfate
14 Mycophenolate Mofetil for IgA Nephropathy Completed NCT00863252 Phase 4 mycophenolate mofetil;angiotensin blockade
15 Comparing the Efficacy of Tacrolimus and Mycophenolate Mofetil for the Initial Therapy of Active Lupus Nephritis Completed NCT00371319 Phase 4 tacrolimus;mycophenolate mofetil
16 Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effects Completed NCT02585804 Phase 4 Dapagliflozin
17 A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome Completed NCT01763580 Phase 4 Tacrolimus;Prednisolone
18 The Effects of Angiotensin II Receptor Blockade on Kidney Function and Scarring After Liver Transplant Completed NCT00275639 Phase 4 Cozaar
19 Tacrolimus for the Treatment of Systemic Lupus Erythematosus With Membranous Nephritis Completed NCT00125307 Phase 4 tacrolimus
20 Aliskiren for Proteinuric IgAN Despite Angiotensin Blockade Completed NCT00922311 Phase 4 Aliskiren
21 "Steroids and Azathioprine Versus Steroids Alone in IgAN" Completed NCT00755859 Phase 4 steroids plus azathioprine;steroids
22 Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy Completed NCT00498368 Phase 4 Intravenous Rituximab;ACE/ARB
23 To Compare the Efficacy and Safety of Tripterygium Wilfordii (TW) Versus Valsartan in the Membranous Nephropathy (MN) Completed NCT00518219 Phase 4 TW
24 Low-dose Combination of Mycophenolate Mofetil (MMF) and Tacrolimus (Tac) for Refractory Lupus Nephritis Completed NCT01203709 Phase 4 low dose combination of MMF and Tac
25 Pilot Study of Velcade® in IgA Nephropathy Completed NCT01103778 Phase 4 Bortezomib (Velcade®)
26 Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy Completed NCT00367562 Phase 4 ENALAPRIL VALSARTAN METHYLPREDNISONE
27 Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Completed NCT01386554 Phase 4 Repository Corticotropin Injection;Placebo
28 Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH Completed NCT01155141 Phase 4 H.P. Acthar Gel
29 SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus Completed NCT00371826 Phase 4 Everolimus (RAD001);Cyclosporine (Calcineurin Inhibitor (CNI));Methylprednisone/prednisone;Mycophenolate sodium (MPA)
30 Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis Completed NCT02645565 Phase 4 Cyclophosphamide;Azathioprine;Methylprednisolone
31 Immunoadsorption in Anti-GBM Glomerulonephritis. Recruiting NCT02765789 Phase 4
32 Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN) Recruiting NCT03062813 Phase 4 Tacrolimus &entecavir;placebo & entecavir
33 Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy Recruiting NCT02765594 Phase 4 Hydroxychloroquine Sulfate;Valsartan
34 Adrenocorticotropic Hormone in Membranous Nephropathy Recruiting NCT03025828 Phase 4 ACTHar
35 Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy Recruiting NCT03170323 Phase 4 Mycophenolate Mofetil;Cyclosporins
36 Group A Pharyngitis in Children: The GASPARD Study Recruiting NCT03264911 Phase 4 Amoxicillin or Placebo
37 Efficacy and Safety of Artesunate Plus Standard of Care in Active Lupus Nephritis Recruiting NCT03214731 Phase 4 Artesunate
38 Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis Recruiting NCT02630628 Phase 4 Tacrolimus;Mycophenolate mofetil
39 ACTHar in the Treatment of Lupus Nephritis Recruiting NCT02226341 Phase 4 CellCept;ACTHar gel;ACTHar gel
40 Treatment of Proteinuria Due to Treatment Resistant or Treatment Intolerant Idiopathic FSGS Recruiting NCT02633046 Phase 4 Acthar 80 U 2x/week;Acthar 80 U 3x/week
41 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Active, not recruiting NCT00843856 Phase 4 tacrolimus;tacrolimus and mycophenolate mofetil
42 Prevention in Recipients With Primary IgA Nephropathy of Recurrence After Kidney Transplantation: ATG-F Versus Basiliximab as Induction Immunosuppressive Treatment Active, not recruiting NCT02523768 Phase 4 ATG-F;Simulect
43 Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT03218852 Phase 4 prednisone and cyclophosphamide;prednisone alone
44 Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
45 Effect of Immunosuppression in IgA Nephropathy Not yet recruiting NCT03468972 Phase 4 Immunosuppressive treatment
46 Comparative Effectiveness of CEUS Versus DMSA in Renal Scarring Detection Not yet recruiting NCT03653702 Phase 4 Lumason
47 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
48 A Study to Evaluate the Efficacy and Safety of Tacrolimus With Steroid in Korean Lupus Nephritis Patients Terminated NCT01316133 Phase 4 tacrolimus
49 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Withdrawn NCT01926054 Phase 4 Acthar gel
50 The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria Withdrawn NCT00508898 Phase 4 Calcitriol;Multivitamin

Search NIH Clinical Center for Glomerulonephritis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Glomerulonephritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Glomerulonephritis:
Mesenchymal stromal cells for glomerulonephritis
Embryonic/Adult Cultured Cells Related to Glomerulonephritis:
Bone marrow-derived mesenchymal stromal cells PMIDs: 22172807

Cochrane evidence based reviews: glomerulonephritis

Genetic Tests for Glomerulonephritis

Anatomical Context for Glomerulonephritis

The Foundational Model of Anatomy Ontology organs/tissues related to Glomerulonephritis:

19
Kidney

MalaCards organs/tissues related to Glomerulonephritis:

41
Kidney, Neutrophil, T Cells, Liver, Bone, B Cells, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Glomerulonephritis:
# Tissue Anatomical CompartmentCell Relevance
1 Kidney Glomerulus Affected by disease

Publications for Glomerulonephritis

Articles related to Glomerulonephritis:

(show top 50) (show all 5412)
# Title Authors Year
1
Treatment of recurrent, post-kidney transplant membranoproliferative glomerulonephritis with plasmapheresis and rituximab: A case report and literature review
. ( 30431428 )
2019
2
Infection-Related Glomerulonephritis. ( 30454751 )
2019
3
Poststreptococcal Glomerulonephritis and Antibiotics: A Fresh Look at Old Data. ( 30095005 )
2019
4
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. ( 29290203 )
2018
5
Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study. ( 29955611 )
2018
6
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )
2018
7
Parathyroid Hormone-Related Protein Contributes to Early Healing of Habu Snake Venom-Induced Glomerulonephritis in Mice. ( 29353060 )
2018
8
18F-FDG PET/CT Imaging of Necrotizing Crescentic Glomerulonephritis With Anti-Glomerular Basement Membrane Disease. ( 29293138 )
2018
9
Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity?a8c. ( 29057733 )
2018
10
Tuberculosis and pauci-immune crescentic glomerulonephritis. ( 29437730 )
2018
11
Bilateral Diffuse and Cluster Pigment Epithelial Detachment Associated with Diffuse Proliferative Glomerulonephritis. ( 29675279 )
2018
12
Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress. ( 29607219 )
2018
13
Posterior reversible encephalopathy syndrome secondary to asymptomatic poststreptococcal glomerulonephritis in a child with sickle cell anemia: a case report. ( 29386039 )
2018
14
Pauci-immune crescentic glomerulonephritis in a patient with B-lymphocyte poly/autoreactivity. ( 29465375 )
2018
15
Urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratio as predictors of complete remission in primary glomerulonephritis. ( 29414320 )
2018
16
An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis. ( 29923438 )
2018
17
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. ( 29980767 )
2018
18
Membranous glomerulonephritis with an LMNA mutation. ( 29349732 )
2018
19
Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report. ( 29901607 )
2018
20
Microscopic polyangiitis necrotizing glomerulonephritis associated with pregnancy: case with a 20-year clinical course and review of the literature. ( 29869147 )
2018
21
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndromea8c. ( 29350173 )
2018
22
C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy. ( 29310824 )
2018
23
Essential Thrombocythemia Presenting as Paraneoplastic Glomerulonephritis. ( 29962681 )
2018
24
Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy. ( 29948306 )
2018
25
Prognostic Factors in Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis with Severe Glomerular Sclerosis: A National Registry-Based Cohort Study. ( 29973979 )
2018
26
Perinuclear Antineutrophil Cytoplasmic Antibody Positive Glomerulonephritis in a Case of Limited Cutaneous Scleroderma. ( 29962679 )
2018
27
The treatment of ANCA-associated rapidly-progressive glomerulonephritis and Goodpasture syndrome with therapeutic apheresis. ( 29503131 )
2018
28
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Lambda Deposits: Report of the First Pediatric Case. ( 29850460 )
2018
29
IgA-dominant extracapillary proliferative glomerulonephritis following Escherichia coli sepsis in a renal transplant recipient. ( 29809306 )
2018
30
Assessment of the etiologies and renal outcomes of rapidly progressive glomerulonephritis in pediatric patients at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. ( 29619486 )
2018
31
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults. ( 29616329 )
2018
32
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
33
Recurrent postinfectious glomerulonephritis: an unusual evolution compatible with C3 glomerulopathy. ( 29477994 )
2018
34
Necrotizing Crescentic Glomerulonephritis Complicating Bivalvular Bacterial Endocarditis. ( 29942723 )
2018
35
Poststreptococcal glomerulonephritis with atypical hemolytic uremic syndrome: An unusual presentation. ( 29970754 )
2018
36
C3 glomerulonephritis secondary to mutations in factors H and I: rapid recurrence in deceased donor kidney transplant effectively treated with eculizumab. ( 29370420 )
2018
37
Fibrillary Glomerulonephritis in a Patient with Sjogren's Syndrome. ( 29922524 )
2018
38
Primary membranous nephropathy presenting with crescentic glomerulonephritis 25 years after initial presentation: A case reporta8c. ( 29932409 )
2018
39
Fundus changes in type III membranoproliferative glomerulonephritis: a case report. ( 29510686 )
2018
40
Rapidly progressive glomerulonephritis: A wild card manifestation of lupus nephritis. ( 29657218 )
2018
41
Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves. ( 29628480 )
2018
42
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft. ( 29716794 )
2018
43
Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature. ( 29962675 )
2018
44
Quantitative characterization of glomerular fibrosis with magnetic resonance imaging: a feasibility study in a rat glomerulonephritis model. ( 29357425 )
2018
45
Pulmonary renal syndrome: A case report of diffuse alveolar hemorrhage in association with ANCA negative pauci-immune glomerulonephritis. ( 29879042 )
2018
46
Rapidly progressive glomerulonephritis caused by overlap syndrome of IgG4-related tubulointerstitial nephritis and myeloperoxidase-antineutrophil cytoplasmic antibody-associated necrotising glomerulonephritis. ( 29352845 )
2018
47
Fibrillary glomerulonephritis in an HIV patient without concurrent hepatitis C infection: CaseA report and review of the literaturea8c. ( 29578397 )
2018
48
OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis. ( 29939347 )
2018
49
A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation. ( 29968411 )
2018
50
Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with detection of myeloperoxidase and phospholipase A<sub>2</sub> receptor in membranous nephropathy-lesions: report of two patients with microscopic polyangiitis. ( 29792176 )
2018

Variations for Glomerulonephritis

Copy number variations for Glomerulonephritis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21052 1 156500000 165500000 Copy number FCGR3 Glomerulonephritis
2 21055 1 156500000 165500000 Loss FCGR3B Glomerulonephritis
3 21056 1 156500000 165500000 Low copy number FCGR3B Glomerulonephritis

Expression for Glomerulonephritis

Search GEO for disease gene expression data for Glomerulonephritis.

Pathways for Glomerulonephritis

Pathways related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 C1QC C1S C3 C4A C4B CCL2
2
Show member pathways
12.15 ALB CCL2 LRP2 MPO
3
Show member pathways
12.09 C1QC C1S C3 C4A C4B CFH
4 12 C1QC C1S C3 C4A C4B CFH
5 11.75 CCL2 COL4A3 COL4A5 TGFB1
6 11.68 COL4A3 COL4A5 TGFB1
7 11.68 C1QC C1S C3 C4A C4B
8 11.64 COL4A3 COL4A5 CR1 NPHS1 TGFB1
9
Show member pathways
11.58 C1QC C1S C3 C4A C4B CFH
10 11.45 C1QC C1S C3 C4A C4B CFH
11
Show member pathways
11.4 C1QC C1S C3 C4A C4B CFH
12 11.36 COL4A3 COL4A5 TGFB1
13 11.34 CCL2 CR1 TGFB1
14 10.74 CCL2 MPO

GO Terms for Glomerulonephritis

Cellular components related to Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB C1QC C1S C3 C4A C4B
2 endoplasmic reticulum lumen GO:0005788 9.8 ALB C3 C4A CFP COL4A3 COL4A5
3 blood microparticle GO:0072562 9.76 ALB C1QC C1S C3 C4A C4B
4 collagen-containing extracellular matrix GO:0062023 9.73 C1QC CFP COL4A3 COL4A5 PRTN3 TGFB1
5 azurophil granule lumen GO:0035578 9.63 C3 MPO PRTN3
6 collagen trimer GO:0005581 9.61 C1QC COL4A3 COL4A5
7 extracellular space GO:0005615 9.5 ALB C1QC C1S C3 C4A C4B
8 collagen type IV trimer GO:0005587 9.4 COL4A3 COL4A5
9 extracellular exosome GO:0070062 10.11 ALB C3 C4A C4B CFH CFI

Biological processes related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.97 C1QC C1S C3 C4A C4B CFH
2 immune system process GO:0002376 9.95 C3 C4A C4B CD79A CR1
3 neutrophil degranulation GO:0043312 9.89 C3 CFP CR1 MPO PRTN3
4 inflammatory response GO:0006954 9.85 C3 C4A C4B CCL2 TGFB1
5 complement activation, classical pathway GO:0006958 9.8 C1QC C1S C3 C4A C4B CFI
6 negative regulation of endopeptidase activity GO:0010951 9.73 C3 C4A C4B COL4A3
7 complement activation, alternative pathway GO:0006957 9.67 C3 CFH CFHR5 CFP
8 regulation of regulatory T cell differentiation GO:0045589 9.54 CR1 TGFB1
9 negative regulation of phagocytosis GO:0050765 9.52 PRTN3 TGFB1
10 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.51 COL4A3 COL4A5
11 complement activation GO:0006956 9.5 C1QC C1S C3 C4A C4B CFH
12 glomerular basement membrane development GO:0032836 9.48 COL4A3 NPHS1
13 positive regulation of apoptotic cell clearance GO:2000427 9.46 C3 C4A C4B CCL2
14 regulation of complement activation GO:0030449 9.32 C1QC C1S C3 C4A C4B CFH
15 proteolysis GO:0006508 10.01 C1QC C1S C3 C4A C4B CFI

Molecular functions related to Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.23 C1QC C1S C3 C4A C4B CFI
2 endopeptidase inhibitor activity GO:0004866 9.13 C3 C4A C4B

Sources for Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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