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MCID: GLM007
MIFTS: 61

Glomerulonephritis

Categories: Rare diseases, Nephrological diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Glomerulonephritis

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MalaCards integrated aliases for Glomerulonephritis:

Name: Glomerulonephritis 38 12 76 53 55 44 15 73
Bright's Disease 53

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Nephrological diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2921
ICD10 33 N05 N08
MeSH 44 D005921
NCIt 50 C26784
SNOMED-CT 68 197648001 36171008
UMLS 73 C0017658
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Summaries for Glomerulonephritis

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NIH Rare Diseases : 53 Glomerulonephritis is a type of kidney disease in which there is inflammation of the glomeruli, the tiny filters that remove excess waste and fluids from the blood. It may be acute or chronic (coming on gradually), and may occur on its own (primary) or be caused by another condition (secondary). Signs and symptoms may depend on the type and cause of the condition and may include blood in the urine; foamy urine; swelling of the face, eyes, or other body parts; abdominal pain; high blood pressure; fatigue; and/or other symptoms. If the condition is severe or prolonged, the kidneys can become damaged. It may be caused by a variety of infections and diseases, and sometimes the cause is unknown. Treatment depends on the cause, type and severity of the condition.

MalaCards based summary : Glomerulonephritis, also known as bright's disease, is related to dense deposit disease and immune-complex glomerulonephritis. An important gene associated with Glomerulonephritis is CFHR5 (Complement Factor H Related 5), and among its related pathways/superpathways are Innate Immune System and Folate Metabolism. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include Kidney, kidney and kidney, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A nephritis that causes inflammation of the glomeruli located in kidney.

Wikipedia : 76 Glomerulonephritis (GN), also known as glomerular nephritis, is a term used to refer to several kidney... more...

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Related Diseases for Glomerulonephritis

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Diseases in the Glomerulonephritis family:

Subacute Glomerulonephritis

Diseases related to Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 641)
# Related Disease Score Top Affiliating Genes
1 dense deposit disease 34.4 C3 CFH CFHR5
2 immune-complex glomerulonephritis 34.4 C4B CFI MPO
3 rapidly progressive glomerulonephritis 34.3 CD79A MPO PRTN3 TGFB1
4 complement factor h deficiency 33.9 CFH CFI
5 exudative glomerulonephritis 33.8 CD40LG CD79A
6 proliferative glomerulonephritis 33.7 C3 CCL2 CD79A CFH CR1
7 goodpasture syndrome 33.5 CD79A COL4A3 COL4A5 MPO
8 acute proliferative glomerulonephritis 33.4 CCL2 CD40LG CD79A COL4A3 MPO
9 c3 glomerulopathy 33.4 C3 CFHR5 CFP
10 alport syndrome, x-linked 32.8 CD79A COL4A3 COL4A5
11 diffuse glomerulonephritis 32.8 ALB CD40LG CD79A CFP
12 membranoproliferative glomerulonephritis 32.5 ALB C3 CD79A CFH CFHR5 CFP
13 henoch-schoenlein purpura 32.0 C3 CD40LG CD79A MPO
14 lipoid nephrosis 31.7 ALB CCL2 CD79A NPHS1
15 membranous nephropathy 31.6 ALB C3 CD79A LRP2 MPO NPHS1
16 iga glomerulonephritis 31.4 ALB CCL2 CD40LG CD79A CFP NPHS1
17 hemolytic-uremic syndrome 31.2 C3 CFH CFHR5 CFI
18 churg-strauss syndrome 30.7 CD40LG MPO PRTN3
19 lupus erythematosus 30.5 C1QC C1S C3 C4B CD40LG
20 vasculitis 30.4 CCL2 CD40LG CD79A MPO PRTN3
21 peritonitis 30.4 ALB CCL2 MPO
22 subacute bacterial endocarditis 30.4 CD40LG CD79A
23 lyme disease 30.3 C3 CD40LG CFH
24 focal segmental glomerulosclerosis 30.3 ALB COL4A3 COL4A5 NPHS1 TGFB1
25 c1q nephropathy 30.3 CD40LG CD79A
26 lung disease 30.1 CCL2 MPO PRTN3 TGFB1
27 microvascular complications of diabetes 3 30.1 ALB NPHS1 TGFB1
28 cholangitis 30.0 ALB CD40LG PRTN3
29 pulmonary hemosiderosis 29.9 CD40LG CD79A MPO PRTN3
30 macular degeneration, age-related, 1 29.9 C3 CCL2 CFH CFHR5 CFI
31 anemia, autoimmune hemolytic 29.9 C1S C3 CD40LG CD79A
32 sclerosing cholangitis 29.9 ALB CD40LG MPO
33 complement factor i deficiency 29.8 C3 C4B CFI CFP CR1
34 rheumatoid arthritis 29.8 CCL2 CD40LG CD79A PRTN3 TGFB1
35 tolosa-hunt syndrome 29.7 CD40LG PRTN3
36 immunoglobulin a deficiency 1 29.7 CD40LG CD79A
37 systemic lupus erythematosus 29.7 ALB C1QC C1S C3 C4B CCL2
38 bronchopneumonia 29.7 CD40LG CD79A MPO
39 cogan syndrome 29.6 CD40LG CD79A COL4A3
40 schistosomiasis 29.6 ALB CD40LG CD79A
41 meningitis 29.4 ALB CCL2 CD40LG CFP
42 guillain-barre syndrome 29.4 ALB CD40LG CD79A
43 congenital syphilis 29.4 CD40LG CD79A
44 acquired immunodeficiency syndrome 29.3 ALB CD40LG CD79A
45 bronchitis 29.2 ALB CD40LG CD79A MPO
46 end stage renal failure 29.0 ALB CD79A COL4A5 NPHS1 TGFB1
47 chronic kidney failure 28.9 ALB CD79A COL4A5 NPHS1 TGFB1
48 kidney disease 28.4 ALB C3 CCL2 CD79A COL4A3 COL4A5
49 malaria 28.1 ALB CCL2 CD40LG CR1 TGFB1
50 mesangial proliferative glomerulonephritis 12.3

Graphical network of the top 20 diseases related to Glomerulonephritis:



Diseases related to Glomerulonephritis
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Symptoms & Phenotypes for Glomerulonephritis

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GenomeRNAi Phenotypes related to Glomerulonephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.28 ALB C1QC C3 CCL2 CD79A COL4A5

MGI Mouse Phenotypes related to Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 MPO PRTN3 TGFB1 C3 C4B CD40LG
2 cardiovascular system MP:0005385 10.02 C3 C4B CD40LG CFH CFP COL4A3
3 homeostasis/metabolism MP:0005376 10 ALB C3 C4B CD40LG CD79A CFH
4 immune system MP:0005387 9.77 COL4A5 LRP2 MPO PRTN3 TGFB1 C3
5 renal/urinary system MP:0005367 9.4 ALB C3 C4B CD40LG CD79A CFH
Sources

Drugs & Therapeutics for Glomerulonephritis

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Drugs for Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 268)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Losartan Approved Phase 4,Phase 3,Phase 2,Not Applicable 114798-26-4 3961
3
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
4
Cilnidipine Approved, Investigational Phase 4 132203-70-4 5282138
5
Enalapril Approved, Vet_approved Phase 4,Phase 2,Not Applicable 75847-73-3 5362032 40466924
6
Enalaprilat Approved Phase 4,Phase 2,Not Applicable 76420-72-9 6917719
7
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
9
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 174722-31-7 10201696
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
11
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
12
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 104987-11-3 445643 439492
13
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 128794-94-5 5281078
14
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
15
Azathioprine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 446-86-6 2265
16
Triamcinolone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 124-94-7 31307
17
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
18
Ramipril Approved Phase 4,Phase 3 87333-19-5 5362129
19
Probucol Approved, Investigational Phase 4 23288-49-5 4912
20
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
21
Hydroxychloroquine Approved Phase 4 118-42-3 3652
22
Bortezomib Approved, Investigational Phase 4 179324-69-7 387447 93860
23
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
24
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
25
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
26
Amoxicillin Approved, Vet_approved Phase 4,Not Applicable 26787-78-0 33613
27
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
28
Basiliximab Approved, Investigational Phase 4,Phase 2 152923-56-3, 179045-86-4
29
Artesunate Approved, Investigational Phase 4 88495-63-0 6917864 5464098
30
Calcitriol Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 32222-06-3 134070 5280453
31
Serine Approved, Nutraceutical Phase 4,Phase 3 56-45-1 5951
32 tannic acid Approved, Nutraceutical Phase 4,Phase 3
33
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Not Applicable 1406-16-2
34
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 50-14-6 5280793
35
N,N-dimethylarginine Experimental Phase 4 30315-93-6 123831
36
Candesartan Experimental Phase 4 139481-59-7 2541
37
Dexchlorpheniramine Experimental, Investigational Phase 4 25523-97-1 33036
38 Angiotensin II Type 1 Receptor Blockers Phase 4,Phase 2,Phase 3,Not Applicable
39 Angiotensin Receptor Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
40 Angiotensinogen Phase 4,Phase 2,Phase 3,Not Applicable
41 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Not Applicable
42 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
43 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Not Applicable
45 Calcium, Dietary Phase 4,Phase 2,Phase 3,Not Applicable
46 Immunoglobulin A Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
49 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
50 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 355)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis Unknown status NCT02063100 Phase 4 Shenyankangfu tablets;Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 100mg;Losartan potassium 100mg
2 Calcitriol in the Treatment of Immunoglobulin A Nephropathy Unknown status NCT00862693 Phase 4 Calcitriol
3 A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy Unknown status NCT01184599 Phase 4 aliskiren
4 CCB Safety Study in Treatment of Hypertension of ADPKD Unknown status NCT00541853 Phase 4 Candesartan;Candesartan and Cilnidipine;Candesartan plus non-CCB agents
5 Rituximab in Recurrent IgA Nephropathy Unknown status NCT02571842 Phase 4 Intravenous Rituximab;ACEI/ARB and corticosteroids
6 Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy Unknown status NCT02231125 Phase 4 Losartan;Abelmoschus manihot
7 Inhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis Completed NCT01115426 Phase 4 Ramipril or losartan
8 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
9 Long-Acting Tacrolimus for the Treatment of Resistant Lupus Nephritis Completed NCT01206569 Phase 4 Long-acting tacrolimus (Advagraf, Astellas Pharma)
10 Calcitriol in the Treatment of Immunoglobulin A (IgA) Nephropathy Completed NCT00319761 Phase 4 Calcitriol
11 A Study of the Antioxidant Probucol Combined With Valsartan in Patients With IgA Nephropathy Completed NCT00426348 Phase 4 Valsartan;Probucol;Placebo
12 Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy: a Self- Controlled Study Completed NCT02351752 Phase 4 Hydroxychloroquine Sulfate
13 Mycophenolate Mofetil for IgA Nephropathy Completed NCT00863252 Phase 4 mycophenolate mofetil;angiotensin blockade
14 Comparing the Efficacy of Tacrolimus and Mycophenolate Mofetil for the Initial Therapy of Active Lupus Nephritis Completed NCT00371319 Phase 4 tacrolimus;mycophenolate mofetil
15 Treating to Reduce Albuminuria and Normalize Hemodynamic Function in Focal ScLerosis With dApagliflozin Trial Effects Completed NCT02585804 Phase 4 Dapagliflozin
16 A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome Completed NCT01763580 Phase 4 Tacrolimus;Prednisolone
17 The Effects of Angiotensin II Receptor Blockade on Kidney Function and Scarring After Liver Transplant Completed NCT00275639 Phase 4 Cozaar
18 Tacrolimus for the Treatment of Systemic Lupus Erythematosus With Membranous Nephritis Completed NCT00125307 Phase 4 tacrolimus
19 Aliskiren for Proteinuric IgAN Despite Angiotensin Blockade Completed NCT00922311 Phase 4 Aliskiren
20 "Steroids and Azathioprine Versus Steroids Alone in IgAN" Completed NCT00755859 Phase 4 steroids plus azathioprine;steroids
21 Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy Completed NCT00498368 Phase 4 Intravenous Rituximab;ACE/ARB
22 To Compare the Efficacy and Safety of Tripterygium Wilfordii (TW) Versus Valsartan in the Membranous Nephropathy (MN) Completed NCT00518219 Phase 4 TW
23 Low-dose Combination of Mycophenolate Mofetil (MMF) and Tacrolimus (Tac) for Refractory Lupus Nephritis Completed NCT01203709 Phase 4 low dose combination of MMF and Tac
24 Pilot Study of Velcade® in IgA Nephropathy Completed NCT01103778 Phase 4 Bortezomib (Velcade®)
25 Inhibition of the Renin Angiotensin System Plus Corticosteroids for the Treatment of Proteinuria in IGA Nephropathy Completed NCT00367562 Phase 4 ENALAPRIL VALSARTAN METHYLPREDNISONE
26 Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Completed NCT01386554 Phase 4 Repository Corticotropin Injection;Placebo
27 Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH Completed NCT01155141 Phase 4 H.P. Acthar Gel
28 SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus Completed NCT00371826 Phase 4 Everolimus (RAD001);Cyclosporine (Calcineurin Inhibitor (CNI));Methylprednisone/prednisone;Mycophenolate sodium (MPA)
29 Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis Completed NCT02645565 Phase 4 Cyclophosphamide;Azathioprine;Methylprednisolone
30 Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN) Recruiting NCT03062813 Phase 4 Tacrolimus &entecavir;placebo & entecavir
31 Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy Recruiting NCT02765594 Phase 4 Hydroxychloroquine Sulfate;Valsartan
32 Adrenocorticotropic Hormone in Membranous Nephropathy Recruiting NCT03025828 Phase 4 ACTHar
33 Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy Recruiting NCT02981212 Phase 4 Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
34 Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy Recruiting NCT03170323 Phase 4 Mycophenolate Mofetil;Cyclosporins
35 Group A Pharyngitis in Children: The GASPARD Study Recruiting NCT03264911 Phase 4 Amoxicillin or Placebo
36 Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis Recruiting NCT02630628 Phase 4 Tacrolimus;Mycophenolate mofetil
37 ACTHar in the Treatment of Lupus Nephritis Recruiting NCT02226341 Phase 4 CellCept;ACTHar gel;ACTHar gel
38 Treatment of Proteinuria Due to Treatment Resistant or Treatment Intolerant Idiopathic FSGS Recruiting NCT02633046 Phase 4 Acthar 80 U 2x/week;Acthar 80 U 3x/week
39 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Active, not recruiting NCT00843856 Phase 4 tacrolimus;tacrolimus and mycophenolate mofetil
40 Prevention in Recipients With Primary IgA Nephropathy of Recurrence After Kidney Transplantation: ATG-F Versus Basiliximab as Induction Immunosuppressive Treatment Active, not recruiting NCT02523768 Phase 4 ATG-F;Simulect
41 Extended Follow-up of Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT03218852 Phase 4 prednisone and cyclophosphamide;prednisone alone
42 Treatment of Prednisone Plus Cyclophosphamide in Patients With Advanced-stage IgA Nephropathy Active, not recruiting NCT01758120 Phase 4 prednisone plus cyclophosphamide;Prednisone alone
43 Immunoadsorption in Anti-GBM Glomerulonephritis. Not yet recruiting NCT02765789 Phase 4
44 Effect of Immunosuppression in IgA Nephropathy Not yet recruiting NCT03468972 Phase 4 Immunosuppressive treatment
45 Efficacy and Safety of Artesunate Plus Standard of Care in Active Lupus Nephritis Not yet recruiting NCT03214731 Phase 4 Artesunate
46 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
47 A Study to Evaluate the Efficacy and Safety of Tacrolimus With Steroid in Korean Lupus Nephritis Patients Terminated NCT01316133 Phase 4 tacrolimus
48 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Withdrawn NCT01926054 Phase 4 Acthar gel
49 The Efficacy and Safety of Calcitriol for the Treatment of Lupus Nephritis and Persistent Proteinuria Withdrawn NCT00508898 Phase 4 Calcitriol;Multivitamin
50 Acthar on Proteinuria in IgA Nephropathy Patients Withdrawn NCT02382523 Phase 4 Acthar 80 unit injection

Search NIH Clinical Center for Glomerulonephritis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Glomerulonephritis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Glomerulonephritis:
Mesenchymal stromal cells for glomerulonephritis
Embryonic/Adult Cultured Cells Related to Glomerulonephritis:
Bone marrow-derived mesenchymal stromal cells PMIDs: 22172807

Cochrane evidence based reviews: glomerulonephritis

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Genetic Tests for Glomerulonephritis

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Anatomical Context for Glomerulonephritis

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The Foundational Model of Anatomy Ontology organs/tissues related to Glomerulonephritis:

19
Kidney

MalaCards organs/tissues related to Glomerulonephritis:

41
Kidney, Neutrophil, T Cells, Liver, Monocytes, Bone, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Glomerulonephritis:
# Tissue Anatomical CompartmentCell Relevance
1 Kidney Glomerulus Affected by disease
Sources

Publications for Glomerulonephritis

About this section

Articles related to Glomerulonephritis:

(show top 50) (show all 4084)
# Title Authors Year
1
Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl. ( 29290203 )
2018
2
Prognosis and Histological Classification in Elderly Patients with ANCA-Glomerulonephritis: A Registry-Based Cohort Study. ( 29955611 )
2018
3
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway. ( 29782856 )
2018
4
Parathyroid Hormone-Related Protein Contributes to Early Healing of Habu Snake Venom-Induced Glomerulonephritis in Mice. ( 29353060 )
2018
5
18F-FDG PET/CT Imaging of Necrotizing Crescentic Glomerulonephritis With Anti-Glomerular Basement Membrane Disease. ( 29293138 )
2018
6
Membranoproliferative glomerulonephritis with unusual deposits of parallel arrangement striated structure: a new pathological entity?a8c. ( 29057733 )
2018
7
Tuberculosis and pauci-immune crescentic glomerulonephritis. ( 29437730 )
2018
8
Bilateral Diffuse and Cluster Pigment Epithelial Detachment Associated with Diffuse Proliferative Glomerulonephritis. ( 29675279 )
2018
9
Lactic Acid Bacteria Isolated from Japanese Fermented Fish (Funa-Sushi) Inhibit Mesangial Proliferative Glomerulonephritis by Alcohol Intake with Stress. ( 29607219 )
2018
10
Posterior reversible encephalopathy syndrome secondary to asymptomatic poststreptococcal glomerulonephritis in a child with sickle cell anemia: a case report. ( 29386039 )
2018
11
Pauci-immune crescentic glomerulonephritis in a patient with B-lymphocyte poly/autoreactivity. ( 29465375 )
2018
12
Urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratio as predictors of complete remission in primary glomerulonephritis. ( 29414320 )
2018
13
An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis. ( 29923438 )
2018
14
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. ( 29980767 )
2018
15
Membranous glomerulonephritis with an LMNA mutation. ( 29349732 )
2018
16
Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report. ( 29901607 )
2018
17
Microscopic polyangiitis necrotizing glomerulonephritis associated with pregnancy: case with a 20-year clinical course and review of the literature. ( 29869147 )
2018
18
Membranoproliferative glomerulonephritis and interstitial nephritis in the setting of Epstein-Barr virus-related hemophagocytic syndromea8c. ( 29350173 )
2018
19
C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy. ( 29310824 )
2018
20
Essential Thrombocythemia Presenting as Paraneoplastic Glomerulonephritis. ( 29962681 )
2018
21
Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy. ( 29948306 )
2018
22
Prognostic Factors in Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis with Severe Glomerular Sclerosis: A National Registry-Based Cohort Study. ( 29973979 )
2018
23
Perinuclear Antineutrophil Cytoplasmic Antibody Positive Glomerulonephritis in a Case of Limited Cutaneous Scleroderma. ( 29962679 )
2018
24
The treatment of ANCA-associated rapidly-progressive glomerulonephritis and Goodpasture syndrome with therapeutic apheresis. ( 29503131 )
2018
25
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Lambda Deposits: Report of the First Pediatric Case. ( 29850460 )
2018
26
IgA-dominant extracapillary proliferative glomerulonephritis following Escherichia coli sepsis in a renal transplant recipient. ( 29809306 )
2018
27
Assessment of the etiologies and renal outcomes of rapidly progressive glomerulonephritis in pediatric patients at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. ( 29619486 )
2018
28
Proliferative glomerulonephritis with monoclonal IgG deposits in children and young adults. ( 29616329 )
2018
29
Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-SchAPnlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature. ( 29900000 )
2018
30
Recurrent postinfectious glomerulonephritis: an unusual evolution compatible with C3 glomerulopathy. ( 29477994 )
2018
31
Necrotizing Crescentic Glomerulonephritis Complicating Bivalvular Bacterial Endocarditis. ( 29942723 )
2018
32
Poststreptococcal glomerulonephritis with atypical hemolytic uremic syndrome: An unusual presentation. ( 29970754 )
2018
33
C3 glomerulonephritis secondary to mutations in factors H and I: rapid recurrence in deceased donor kidney transplant effectively treated with eculizumab. ( 29370420 )
2018
34
Fibrillary Glomerulonephritis in a Patient with Sjogren's Syndrome. ( 29922524 )
2018
35
Primary membranous nephropathy presenting with crescentic glomerulonephritis 25 years after initial presentation: A case reporta8c. ( 29932409 )
2018
36
Fundus changes in type III membranoproliferative glomerulonephritis: a case report. ( 29510686 )
2018
37
Rapidly progressive glomerulonephritis: A wild card manifestation of lupus nephritis. ( 29657218 )
2018
38
Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves. ( 29628480 )
2018
39
Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft. ( 29716794 )
2018
40
Monoclonal Gammopathy of Renal Significance Presenting as Cryoglobulinemic Glomerulonephritis: A Case Report and Review of Literature. ( 29962675 )
2018
41
Quantitative characterization of glomerular fibrosis with magnetic resonance imaging: a feasibility study in a rat glomerulonephritis model. ( 29357425 )
2018
42
Pulmonary renal syndrome: A case report of diffuse alveolar hemorrhage in association with ANCA negative pauci-immune glomerulonephritis. ( 29879042 )
2018
43
Rapidly progressive glomerulonephritis caused by overlap syndrome of IgG4-related tubulointerstitial nephritis and myeloperoxidase-antineutrophil cytoplasmic antibody-associated necrotising glomerulonephritis. ( 29352845 )
2018
44
Fibrillary glomerulonephritis in an HIV patient without concurrent hepatitis C infection: CaseA report and review of the literaturea8c. ( 29578397 )
2018
45
OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis. ( 29939347 )
2018
46
A case of recurrent proliferative glomerulonephritis with monoclonal IgG deposits or de novo C3 glomerulonephritis after kidney transplantation. ( 29968411 )
2018
47
Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with detection of myeloperoxidase and phospholipase A<sub>2</sub> receptor in membranous nephropathy-lesions: report of two patients with microscopic polyangiitis. ( 29792176 )
2018
48
Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement. ( 29877285 )
2018
49
A pilot and comparative study between pathological and serological levels of immunoglobulin and complement among three kinds of primary glomerulonephritis. ( 29925312 )
2018
50
WaldenstrAPm macroglobulinemia presenting as cryoglobulinemic type II membranoproliferative glomerulonephritis. ( 29571917 )
2018
Sources

Variations for Glomerulonephritis

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Copy number variations for Glomerulonephritis from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 21052 1 156500000 165500000 Copy number FCGR3 Glomerulonephritis
2 21055 1 156500000 165500000 Loss FCGR3B Glomerulonephritis
3 21056 1 156500000 165500000 Low copy number FCGR3B Glomerulonephritis
Sources

Expression for Glomerulonephritis

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Search GEO for disease gene expression data for Glomerulonephritis.
Sources

Pathways for Glomerulonephritis

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Pathways related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.87 C1QC C1S C3 C4B CCL2 CD40LG
2
Folate Metabolism 1
Show member pathways
 12.16 ALB CCL2 LRP2 MPO
3
Toxoplasmosis 37
Show member pathways
 12.08 C3 CD40LG CR1 TGFB1
4
Creation of C4 and C2 activators 66
Show member pathways
 12.03 C1QC C1S C3 C4B CFH CFI
5
Complement and coagulation cascades 1 37
11.94 C1QC C1S C3 C4B CFH CFI
6
AGE-RAGE signaling pathway in diabetic complications 37
11.77 CCL2 COL4A3 COL4A5 TGFB1
7
Amoebiasis 37
11.69 COL4A3 COL4A5 TGFB1
8
Pertussis 37
11.64 C1QC C1S C3 C4B
9
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.64 COL4A3 COL4A5 CR1 NPHS1 TGFB1
10
Complement Pathway 64
Show member pathways
 11.53 C1QC C1S C3 C4B CFH CFP
11
Malaria 37
11.4 CCL2 CD40LG CR1 TGFB1
12
Staphylococcus aureus infection 37
11.38 C1QC C1S C3 C4B CFH CFI
13
Cell adhesion_Plasmin signaling 22
11.36 COL4A3 COL4A5 TGFB1
14
Immune response Lectin induced complement pathway 22
Show member pathways
 11.35 C1QC C1S C3 C4B CFH CFI
15
LDL Oxidation in Atherogenesis 64
10.75 CCL2 MPO
Sources

GO Terms for Glomerulonephritis

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Cellular components related to Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 ALB C1QC C1S C3 C4B CCL2
2 endoplasmic reticulum lumen GO:0005788 9.72 ALB C3 CFP COL4A3 COL4A5
3 blood microparticle GO:0072562 9.7 ALB C1QC C1S C3 C4B CFH
4 collagen trimer GO:0005581 9.61 C1QC COL4A3 COL4A5
5 azurophil granule lumen GO:0035578 9.58 C3 MPO PRTN3
6 extracellular region GO:0005576 9.53 ALB C1QC C1S C3 C4B CCL2
7 collagen type IV trimer GO:0005587 9.37 COL4A3 COL4A5
8 extracellular exosome GO:0070062 10.03 ALB C1QC C1S C3 C4B CFH

Biological processes related to Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 C1S C3 C4B CD79A CR1
2 immune response GO:0006955 9.92 C1QC C3 CCL2 CD40LG CFP
3 innate immune response GO:0045087 9.92 C1QC C1S C3 C4B CFH CFI
4 neutrophil degranulation GO:0043312 9.91 C3 CFP CR1 MPO PRTN3
5 proteolysis GO:0006508 9.91 C1QC C1S C3 C4B CFI PRTN3
6 inflammatory response GO:0006954 9.8 C3 C4B CCL2 CD40LG TGFB1
7 complement activation, classical pathway GO:0006958 9.73 C1QC C1S C3 C4B CFI CR1
8 collagen catabolic process GO:0030574 9.63 COL4A3 COL4A5 PRTN3
9 regulation of regulatory T cell differentiation GO:0045589 9.56 CR1 TGFB1
10 negative regulation of phagocytosis GO:0050765 9.54 PRTN3 TGFB1
11 positive regulation of apoptotic cell clearance GO:2000427 9.54 C3 C4B CCL2
12 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.49 COL4A3 COL4A5
13 glomerular basement membrane development GO:0032836 9.48 COL4A3 NPHS1
14 complement activation, alternative pathway GO:0006957 9.46 C3 CFH CFHR5 CFP
15 complement activation GO:0006956 9.43 C1QC C1S C3 C4B CFH CFP
16 regulation of complement activation GO:0030449 9.28 C1QC C1S C3 C4B CFH CFHR5

Molecular functions related to Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ALB C1QC C1S C3 C4B CCL2
2 serine-type endopeptidase activity GO:0004252 9.1 C1QC C1S C3 C4B CFI PRTN3
Sources

Sources for Glomerulonephritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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