MCID: GLM008
MIFTS: 44

Glomus Tumor

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Glomus Tumor

MalaCards integrated aliases for Glomus Tumor:

Name: Glomus Tumor 12 59 55 44 15 73
Glomus Neoplasm 12
Glomus Tumour 12

Characteristics:

Orphanet epidemiological data:

59
glomus tumor
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:2431
MeSH 44 D005918
NCIt 50 C3060
Orphanet 59 ORPHA391651
ICD10 via Orphanet 34 D18.0
UMLS via Orphanet 74 C0017653
UMLS 73 C0017653

Summaries for Glomus Tumor

Disease Ontology : 12 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary : Glomus Tumor, also known as glomus neoplasm, is related to paragangliomas 1 and glomangioma. An important gene associated with Glomus Tumor is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Carbon metabolism. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 A glomus tumor (also known as a \"solitary glomus tumor,\" \"solid glomus tumor,\") is a rare neoplasm... more...

Related Diseases for Glomus Tumor

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 288)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 33.0 SDHB SDHD
2 glomangioma 31.9 ACTC1 DES ENO2 VIM
3 hereditary paraganglioma-pheochromocytoma syndromes 31.5 SDHB SDHD
4 glomangiomyoma 30.9 ACTC1 VIM
5 fibromatosis 29.9 ACTC1 DES VIM
6 carcinoid syndrome 29.8 ENO2 SYP
7 spiradenoma 29.8 TP53 VIM
8 chondroma 29.4 ACTC1 SDHB SDHD
9 paraganglioma 28.7 ENO2 SDHB SDHD SYP
10 merkel cell carcinoma 28.6 ENO2 SYP TP53
11 dermatofibrosarcoma protuberans 28.5 ACTC1 DES TP53 VIM
12 teratoma 27.9 ACTC1 ENO2 SYP TP53
13 leiomyosarcoma 27.7 ACTC1 DES ENO2 TP53 VIM
14 gastrointestinal stromal tumor 25.0 ACTC1 DES ENO2 SDHB SDHD SYP
15 subungual glomus tumor 12.2
16 skin glomus tumor 12.1
17 glomangiosarcoma 11.8
18 glomuvenous malformations 11.5
19 paragangliomas 2 11.2
20 paragangliomas 3 11.2
21 infantile digital fibromatosis 10.7 DES VIM
22 lymphangiomatosis 10.7 DES VIM
23 lymphangiectasis 10.7 ACTC1 VIM
24 biphasic synovial sarcoma 10.7 DES VIM
25 intravascular papillary endothelial hyperplasia 10.7 ACTC1 VIM
26 syringoma 10.7 DES VIM
27 juvenile xanthogranuloma 10.7 DES VIM
28 ovarian fibrothecoma 10.7 ACTC1 DES
29 fibroblastic rheumatism 10.7 ACTC1 DES
30 adenofibroma 10.7 ACTC1 VIM
31 cutaneous leiomyosarcoma 10.7 ACTC1 DES
32 botryoid rhabdomyosarcoma 10.7 ACTC1 DES
33 mesenchymal chondrosarcoma 10.6 DES VIM
34 primary hepatic neuroendocrine carcinoma 10.6 SYP VIM
35 rhabdoid meningioma 10.6 SYP VIM
36 chordoid meningioma 10.6 SYP VIM
37 pulmonary vein stenosis 10.6 ACTC1 DES
38 cystic nephroma 10.6 ACTC1 DES
39 ischemic fasciitis 10.6 ACTC1 DES
40 medulloepithelioma 10.6 SYP VIM
41 ovarian small cell carcinoma 10.6 DES SYP
42 anaplastic ependymoma 10.6 SYP VIM
43 non-langerhans-cell histiocytosis 10.6 ACTC1 DES
44 sertoli cell tumor 10.6 SYP VIM
45 dendritic cell tumor 10.5 ACTC1 VIM
46 polymorphous low-grade adenocarcinoma 10.5 ACTC1 VIM
47 binswanger's disease 10.4 ACTC1 SYP
48 bednar tumor 10.4 ENO2 VIM
49 myoepithelioma 10.4 ACTC1 VIM
50 breast rhabdomyosarcoma 10.4 DES ENO2

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to Glomus Tumor

Symptoms & Phenotypes for Glomus Tumor

MGI Mouse Phenotypes related to Glomus Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 VIM DES ENO2 SDHD SYP TP53
2 cardiovascular system MP:0005385 9.43 ACTC1 DES SDHB SDHD TP53 VIM
3 normal MP:0002873 9.02 ACTC1 SDHB SDHD SYP TP53

Drugs & Therapeutics for Glomus Tumor

Drugs for Glomus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6 Alkylating Agents Phase 2, Phase 3
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antibiotics, Antitubercular Phase 2, Phase 3
9 Antineoplastic Agents, Alkylating Phase 2, Phase 3
10
Isophosphamide mustard Phase 2, Phase 3 0
11 Topoisomerase Inhibitors Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Glomus Tumor

Cochrane evidence based reviews: glomus tumor

Genetic Tests for Glomus Tumor

Anatomical Context for Glomus Tumor

MalaCards organs/tissues related to Glomus Tumor:

41
Smooth Muscle, Trachea, Kidney, Lung, Bone, Liver, Breast

Publications for Glomus Tumor

Articles related to Glomus Tumor:

(show top 50) (show all 591)
# Title Authors Year
1
Gastric Glomus Tumor: An Uncommon Source for an Acute Upper GI Bleed. ( 29862096 )
2018
2
Glomus tumor of the stomach. ( 29756111 )
2018
3
A case of a glomus tumor presenting as an atypical hyperkeratotic papule of the hypothenar palm. ( 29296650 )
2018
4
Rare presentation of the glomus tumor in the stomach. ( 29221662 )
2018
5
The usefulness of nail plate and intraoperative dermoscopy in subungual glomus tumor. ( 29318590 )
2018
6
A case of gastric glomus tumor resection using laparoscopy endoscopy cooperative surgery (LECS). ( 29275234 )
2018
7
Preoperative arterial embolization of endobronchial glomus tumor before endoscopic removal. ( 29609902 )
2018
8
Extradigital glomus tumor mimicking osteomuscular disease. ( 29924235 )
2018
9
Glomus tumor with rare clinical presentation as chronic shoulder pain. ( 29643719 )
2018
10
Rupture of a subungual glomus tumor of the finger. ( 29720134 )
2018
11
Intra-Articular Glomus Tumor- A Rare Presentation. ( 28272676 )
2017
12
Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. ( 28438258 )
2017
13
An Extradigital Glomus Tumor of the Median Antebrachial Vein. ( 28888573 )
2017
14
Intravenous Glomus Tumor Masquerading as Lateral Antebrachial Cutaneous Neuroma. ( 28344537 )
2017
15
Unusual Volar Pulp Location of Glomus Tumor. ( 28203512 )
2017
16
Glomus Tumor of the Toe. ( 28650755 )
2017
17
HAS A GLOMUS TUMOR ALWAYS A QUICK DIAGNOSIS? ( 29446307 )
2017
18
Malignant Glomus Tumor of the Kidney. ( 28262221 )
2017
19
Nonintubated Spontaneous Respiration Anesthesia for Tracheal Glomus Tumor. ( 28734442 )
2017
20
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28141650 )
2017
21
Extradigital glomus tumor of the elbow with preoperative ultrasound-guided wire localization: a case report. ( 28941972 )
2017
22
An incidental finding of an asymptomatic intraneural glomus tumor: A case report and review of the literature. ( 29272030 )
2017
23
Successful Resection of locally infiltrative Glomus Tumor without pulmonary resection. ( 29096341 )
2017
24
Glomus Tumor of the Scrotum: A Case Report and Mini-Review. ( 29234266 )
2017
25
[Primary tracheal malignant glomus tumor with lung metastasis diagnosed by pathological analysis: a case report and literature review]. ( 28910916 )
2017
26
Micrometastatic Gastric Glomus Tumor Confirmed by Next-Generation Sequencing. ( 28675515 )
2017
27
Ultrasound-Guided, Minimally Invasive Resection of a Digital Glomus Tumor. ( 29108647 )
2017
28
Glomus Tumor in the Tarsal Tunnel: A Case Report. ( 28633794 )
2017
29
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
30
A gastric glomus tumor resected using non-exposed endoscopic wall-inversion surgery. ( 29039113 )
2017
31
A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor. ( 27931523 )
2017
32
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28468218 )
2017
33
Subungual onychomycosis due to<i>Aspergillus niger</i>mimicking a glomus tumor: A case report. ( 29188057 )
2017
34
Transducing-Like Enhancer of Split 1: A Potential Immunohistochemical Marker for Glomus Tumor. ( 28632567 )
2017
35
Atypically localized glomus tumor causing anterior interosseous nerve syndrome: A case report. ( 29056390 )
2017
36
Unusual imaging presentation of spinal glomus tumor: case report. ( 29354753 )
2017
37
Glomus Tumor of the Larynx: A Rare Synchronous Paraganglioma in a Patient with Bilateral Carotid Body Tumor Detected on (68)Ga-DOTANOC PET/CT. ( 28680217 )
2017
38
Glomus Tumor of the Sciatic Nerve: An Extraspinal Cause of Sciatica. ( 28934536 )
2017
39
Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature. ( 28698815 )
2017
40
Glomus Tumor of the Neck Detected With 99mTc EDDA HYNIC-TOC. ( 28806247 )
2017
41
Glomus tumor of the stomach-a tumor that needs to be differentiated from gastrointestinal stromal tumor. ( 28501534 )
2017
42
BRAF V600E Mutations Occur in a Subset of Glomus Tumors, and Are Associated With Malignant Histologic Characteristics. ( 28834810 )
2017
43
Tracheal Glomus Tumor: A Case Report and Review of the Literature. ( 28458792 )
2017
44
Gastric glomus tumor. ( 27887020 )
2016
45
Mammalian glomus tumor: Contribution of nerve ultrasound. ( 26788862 )
2016
46
Subungual Glomus Tumor. ( 27556243 )
2016
47
Epithelioid Glomus Tumor of the Uterine Cervix: A Case Report and Review. ( 26630229 )
2016
48
How to treat a glomus tumor of the airways? ( 27601072 )
2016
49
Role of intraoperative dermoscopy in excision of nail unit glomus tumor. ( 27730057 )
2016
50
Duodenal Glomus Tumor: A Rare Cause of Upper GI Bleeding. ( 27033430 )
2016

Variations for Glomus Tumor

Expression for Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for Glomus Tumor

GO Terms for Glomus Tumor

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.16 SDHB SDHD
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 9.16 SYP TP53
2 ubiquinone binding GO:0048039 8.96 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Glomus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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