MCID: GLM008
MIFTS: 44

Glomus Tumor

Categories: Cancer diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Glomus Tumor

MalaCards integrated aliases for Glomus Tumor:

Name: Glomus Tumor 12 60 56 45 15 74
Glomus Neoplasm 12
Glomus Tumour 12

Characteristics:

Orphanet epidemiological data:

60
glomus tumor
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:2431
MeSH 45 D005918
NCIt 51 C3060
SNOMED-CT 69 10438002
ICD10 via Orphanet 35 D18.0
UMLS via Orphanet 75 C0017653
Orphanet 60 ORPHA391651
UMLS 74 C0017653

Summaries for Glomus Tumor

Disease Ontology : 12 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary : Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and paragangliomas 1. An important gene associated with Glomus Tumor is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Carbon metabolism. The drugs Ifosfamide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 77 A glomus tumor (also known as a "solitary glomus tumor," "solid glomus tumor,") is a rare neoplasm... more...

Related Diseases for Glomus Tumor

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 glomangioma 33.2 ACTC1 DES
2 paragangliomas 1 32.8 SDHB SDHD
3 glomangiomyoma 30.5 ACTC1 VIM
4 hemangiopericytoma, malignant 30.1 ACTC1 DES VIM
5 carcinoid syndrome 30.0 ENO2 SYP
6 fibromatosis 29.9 ACTC1 DES VIM
7 hemangioma 29.8 ACTC1 ENO2 SYP
8 chondroma 29.7 ACTC1 SDHB SDHD
9 spiradenoma 29.7 ACTC1 TP53
10 pleomorphic adenoma 29.5 ACTC1 TP53 VIM
11 paraganglioma 29.5 ENO2 SDHB SDHD SYP
12 dermatofibrosarcoma protuberans 29.2 ACTC1 DES TP53 VIM
13 merkel cell carcinoma 29.2 ENO2 SYP TP53
14 teratoma 28.9 ACTC1 ENO2 SYP TP53
15 leiomyosarcoma 28.9 ACTC1 DES ENO2 TP53 VIM
16 gastrointestinal stromal tumor 27.6 ACTC1 DES ENO2 SDHB SDHD SYP
17 subungual glomus tumor 12.4
18 skin glomus tumor 12.3
19 glomangiosarcoma 12.0
20 glomuvenous malformations 11.7
21 paragangliomas 2 11.4
22 paragangliomas 3 11.4
23 myoepithelioma 10.4 ACTC1 VIM
24 dendritic cell tumor 10.4 ACTC1 VIM
25 polymorphous low-grade adenocarcinoma 10.4 ACTC1 VIM
26 mesenchymal chondrosarcoma 10.4 DES VIM
27 pleomorphic liposarcoma 10.3 DES VIM
28 angiomyolipoma 10.3 ACTC1 DES
29 oncocytoma 10.3 SYP VIM
30 fasciitis 10.3 ACTC1 DES
31 ischemic fasciitis 10.3 ACTC1 DES
32 familial isolated dilated cardiomyopathy 10.3 ACTC1 DES
33 fibrolamellar carcinoma 10.3 SYP VIM
34 lymphangiectasis 10.3 ACTC1 VIM
35 anaplastic ependymoma 10.3 SYP VIM
36 lymphangioma 10.3 ACTC1 VIM
37 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
38 binswanger's disease 10.3 ACTC1 SYP
39 infantile digital fibromatosis 10.3 DES VIM
40 lymphangiomatosis 10.3 DES VIM
41 ovarian fibrothecoma 10.3 ACTC1 DES
42 fibroblastic rheumatism 10.3 ACTC1 DES
43 sertoli cell tumor 10.3 SYP VIM
44 cutaneous leiomyosarcoma 10.3 ACTC1 DES
45 botryoid rhabdomyosarcoma 10.3 ACTC1 DES
46 primary hepatic neuroendocrine carcinoma 10.2 SYP VIM
47 adenofibroma 10.2 ACTC1 VIM
48 neurofibromatosis, type iv, of riccardi 10.2
49 biphasic synovial sarcoma 10.2 DES VIM
50 chondroid chordoma 10.2 ENO2 VIM

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to Glomus Tumor

Symptoms & Phenotypes for Glomus Tumor

MGI Mouse Phenotypes related to Glomus Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 DES ENO2 SDHD SYP TP53 VIM
2 cardiovascular system MP:0005385 9.02 ACTC1 DES SDHD TP53 VIM

Drugs & Therapeutics for Glomus Tumor

Drugs for Glomus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
3
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
4
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Topoisomerase Inhibitors Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
2 Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies Recruiting NCT03422679 Phase 1, Phase 2 CB-103

Search NIH Clinical Center for Glomus Tumor

Cochrane evidence based reviews: glomus tumor

Genetic Tests for Glomus Tumor

Anatomical Context for Glomus Tumor

MalaCards organs/tissues related to Glomus Tumor:

42
Smooth Muscle, Trachea, Kidney, Lung, Liver, Breast, Ovary

Publications for Glomus Tumor

Articles related to Glomus Tumor:

(show top 50) (show all 640)
# Title Authors Year
1
Glomus tumor of the stomach treated by laparoscopic distal gastrectomy: A case report. ( 30655795 )
2019
2
Gastrointestinal: Glomus tumor: A rare submucosal tumor of the stomach. ( 30665269 )
2019
3
Rare malignant glomus tumor of the stomach with liver metastases. ( 30766648 )
2019
4
Behavior of primary tracheal glomus tumor, uncertain malignant potential subtype. ( 30799520 )
2019
5
Gastric Glomus Tumor: An Uncommon Source for an Acute Upper GI Bleed. ( 29862096 )
2018
6
Glomus tumor of the stomach. ( 29756111 )
2018
7
A case of a glomus tumor presenting as an atypical hyperkeratotic papule of the hypothenar palm. ( 29296650 )
2018
8
Rare presentation of the glomus tumor in the stomach. ( 29221662 )
2018
9
The usefulness of nail plate and intraoperative dermoscopy in subungual glomus tumor. ( 29318590 )
2018
10
A case of gastric glomus tumor resection using laparoscopy endoscopy cooperative surgery (LECS). ( 29275234 )
2018
11
Preoperative arterial embolization of endobronchial glomus tumor before endoscopic removal. ( 29609902 )
2018
12
Extradigital glomus tumor mimicking osteomuscular disease. ( 29924235 )
2018
13
Glomus tumor with rare clinical presentation as chronic shoulder pain. ( 29643719 )
2018
14
Rupture of a subungual glomus tumor of the finger. ( 29720134 )
2018
15
Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review. ( 28106242 )
2018
16
Rare tumor in unusual location - glomus tumor of the finger pulp (clinical and dermoscopic features): a case report. ( 29981581 )
2018
17
Nail Unit Glomus Tumor with Myxoid and Symplastic Change Presenting with Longitudinal Erythronychia. ( 29998102 )
2018
18
Extradigital Glomus Tumor with Atypical Neuritis Presentation. ( 30116673 )
2018
19
Intravascular Glomus Tumor of the Wrist Causing Chronic Wrist Pain. ( 30154627 )
2018
20
Glomus tumor: a comprehensive review of the clinical and histopathologic features with report of two intraoral cases. ( 30243917 )
2018
21
The glomus tumor resorbed bone and teeth in the mandible: a case report. ( 30253798 )
2018
22
Glomus tumor in the floor of the mouth: a case report and review of the literature. ( 30305096 )
2018
23
A painless glomus tumor: a case report. ( 30333057 )
2018
24
Glomus tumor of the stomach: A case report. ( 30407338 )
2018
25
Central Airway Obstruction Due to Tracheal Glomus Tumor. ( 30464882 )
2018
26
Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF. ( 30556047 )
2018
27
A Rare Case of Glomus Tumor of the Thigh with Literature Review. ( 30740368 )
2018
28
Intra-Articular Glomus Tumor- A Rare Presentation. ( 28272676 )
2017
29
Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. ( 28438258 )
2017
30
An Extradigital Glomus Tumor of the Median Antebrachial Vein. ( 28888573 )
2017
31
Intravenous Glomus Tumor Masquerading as Lateral Antebrachial Cutaneous Neuroma. ( 28344537 )
2017
32
Unusual Volar Pulp Location of Glomus Tumor. ( 28203512 )
2017
33
Glomus Tumor of the Toe. ( 28650755 )
2017
34
HAS A GLOMUS TUMOR ALWAYS A QUICK DIAGNOSIS? ( 29446307 )
2017
35
Malignant Glomus Tumor of the Kidney. ( 28262221 )
2017
36
Nonintubated Spontaneous Respiration Anesthesia for Tracheal Glomus Tumor. ( 28734442 )
2017
37
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28141650 )
2017
38
Extradigital glomus tumor of the elbow with preoperative ultrasound-guided wire localization: a case report. ( 28941972 )
2017
39
An incidental finding of an asymptomatic intraneural glomus tumor: A case report and review of the literature. ( 29272030 )
2017
40
Successful Resection of locally infiltrative Glomus Tumor without pulmonary resection. ( 29096341 )
2017
41
Glomus Tumor of the Scrotum: A Case Report and Mini-Review. ( 29234266 )
2017
42
[Primary tracheal malignant glomus tumor with lung metastasis diagnosed by pathological analysis: a case report and literature review]. ( 28910916 )
2017
43
Micrometastatic Gastric Glomus Tumor Confirmed by Next-Generation Sequencing. ( 28675515 )
2017
44
Ultrasound-Guided, Minimally Invasive Resection of a Digital Glomus Tumor. ( 29108647 )
2017
45
Glomus Tumor in the Tarsal Tunnel: A Case Report. ( 28633794 )
2017
46
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
47
A gastric glomus tumor resected using non-exposed endoscopic wall-inversion surgery. ( 29039113 )
2017
48
A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor. ( 27931523 )
2017
49
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28468218 )
2017
50
Subungual onychomycosis due to<i>Aspergillus niger</i>mimicking a glomus tumor: A case report. ( 29188057 )
2017

Variations for Glomus Tumor

Expression for Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for Glomus Tumor

GO Terms for Glomus Tumor

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.16 SDHB SDHD
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 9.16 SYP TP53
2 ubiquinone binding GO:0048039 8.96 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Glomus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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