MCID: GLM008
MIFTS: 43

Glomus Tumor

Categories: Cancer diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Glomus Tumor

MalaCards integrated aliases for Glomus Tumor:

Name: Glomus Tumor 12 59 55 44 15 73
Glomus Neoplasm 12
Glomus Tumour 12

Characteristics:

Orphanet epidemiological data:

59
glomus tumor
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:2431
MeSH 44 D005918
NCIt 50 C3060
SNOMED-CT 68 10438002
Orphanet 59 ORPHA391651
ICD10 via Orphanet 34 D18.0
UMLS via Orphanet 74 C0017653
UMLS 73 C0017653

Summaries for Glomus Tumor

Disease Ontology : 12 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary : Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and paragangliomas 1. An important gene associated with Glomus Tumor is VIM (Vimentin), and among its related pathways/superpathways are Cytoskeletal Signaling and Carbon metabolism. The drugs Ifosfamide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, trachea and kidney, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 A glomus tumor (also known as a "solitary glomus tumor," "solid glomus tumor,") is a rare neoplasm... more...

Related Diseases for Glomus Tumor

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 292)
# Related Disease Score Top Affiliating Genes
1 glomangioma 33.0 ACTC1 DES
2 paragangliomas 1 32.7 SDHB SDHD
3 hereditary paraganglioma-pheochromocytoma syndromes 31.9 SDHB SDHD
4 glomangiomyoma 30.3 ACTC1 VIM
5 carcinoid syndrome 29.9 ENO2 SYP
6 fibromatosis 29.9 ACTC1 DES VIM
7 hemangiopericytoma, malignant 29.8 ACTC1 DES VIM
8 hemangioma 29.8 ACTC1 ENO2 SYP
9 paraganglioma 29.8 ENO2 SDHB SDHD SYP
10 chondroma 29.7 ACTC1 SDHB SDHD
11 spiradenoma 29.6 ACTC1 TP53 VIM
12 pleomorphic adenoma 29.6 ACTC1 TP53 VIM
13 dermatofibrosarcoma protuberans 29.4 ACTC1 DES TP53 VIM
14 merkel cell carcinoma 29.4 ENO2 SYP TP53
15 leiomyosarcoma 29.3 ACTC1 DES ENO2 TP53 VIM
16 teratoma 29.2 ACTC1 ENO2 SYP TP53
17 gastrointestinal stromal tumor 28.5 ACTC1 DES ENO2 SDHB SDHD SYP
18 subungual glomus tumor 12.4
19 skin glomus tumor 12.2
20 glomangiosarcoma 11.9
21 glomuvenous malformations 11.7
22 paragangliomas 2 11.4
23 paragangliomas 3 11.4
24 mesenchymal chondrosarcoma 10.2 DES VIM
25 pleomorphic liposarcoma 10.2 DES VIM
26 myoepithelioma 10.2 ACTC1 VIM
27 dendritic cell tumor 10.2 ACTC1 VIM
28 polymorphous low-grade adenocarcinoma 10.2 ACTC1 VIM
29 angiomyolipoma 10.2 ACTC1 DES
30 oncocytoma 10.2 SYP VIM
31 ischemic fasciitis 10.2 ACTC1 DES
32 familial isolated dilated cardiomyopathy 10.2 ACTC1 DES
33 cavernous hemangioma 10.2 SYP VIM
34 fibrolamellar carcinoma 10.2 SYP VIM
35 anaplastic ependymoma 10.2 SYP VIM
36 infantile digital fibromatosis 10.2 DES VIM
37 lymphangiomatosis 10.2 DES VIM
38 lymphangiectasis 10.2 ACTC1 VIM
39 lymphangioma 10.2 ACTC1 VIM
40 binswanger's disease 10.2 ACTC1 SYP
41 intravascular papillary endothelial hyperplasia 10.2 ACTC1 VIM
42 ovarian fibrothecoma 10.2 ACTC1 DES
43 fibroblastic rheumatism 10.2 ACTC1 DES
44 syringocystadenoma papilliferum 10.2 DES VIM
45 sertoli cell tumor 10.2 SYP VIM
46 botryoid rhabdomyosarcoma 10.2 ACTC1 DES
47 biphasic synovial sarcoma 10.2 DES VIM
48 primary hepatic neuroendocrine carcinoma 10.2 SYP VIM
49 chondroid chordoma 10.2 ENO2 VIM
50 pericardial mesothelioma 10.1 ENO2 VIM

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to Glomus Tumor

Symptoms & Phenotypes for Glomus Tumor

MGI Mouse Phenotypes related to Glomus Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 DES ENO2 SDHD SYP TP53 VIM
2 cardiovascular system MP:0005385 9.1 ACTC1 DES SDHB SDHD TP53 VIM

Drugs & Therapeutics for Glomus Tumor

Drugs for Glomus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
3
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
4
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Topoisomerase Inhibitors Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Glomus Tumor

Cochrane evidence based reviews: glomus tumor

Genetic Tests for Glomus Tumor

Anatomical Context for Glomus Tumor

MalaCards organs/tissues related to Glomus Tumor:

41
Smooth Muscle, Trachea, Kidney, Lung, Ovary, Liver, Breast

Publications for Glomus Tumor

Articles related to Glomus Tumor:

(show top 50) (show all 635)
# Title Authors Year
1
Gastric Glomus Tumor: An Uncommon Source for an Acute Upper GI Bleed. ( 29862096 )
2018
2
Glomus tumor of the stomach. ( 29756111 )
2018
3
A case of a glomus tumor presenting as an atypical hyperkeratotic papule of the hypothenar palm. ( 29296650 )
2018
4
Rare presentation of the glomus tumor in the stomach. ( 29221662 )
2018
5
The usefulness of nail plate and intraoperative dermoscopy in subungual glomus tumor. ( 29318590 )
2018
6
A case of gastric glomus tumor resection using laparoscopy endoscopy cooperative surgery (LECS). ( 29275234 )
2018
7
Preoperative arterial embolization of endobronchial glomus tumor before endoscopic removal. ( 29609902 )
2018
8
Extradigital glomus tumor mimicking osteomuscular disease. ( 29924235 )
2018
9
Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review. ( 28106242 )
2018
10
Glomus tumor with rare clinical presentation as chronic shoulder pain. ( 29643719 )
2018
11
Rupture of a subungual glomus tumor of the finger. ( 29720134 )
2018
12
Rare tumor in unusual location - glomus tumor of the finger pulp (clinical and dermoscopic features): a case report. ( 29981581 )
2018
13
Nail Unit Glomus Tumor with Myxoid and Symplastic Change Presenting with Longitudinal Erythronychia. ( 29998102 )
2018
14
Extradigital Glomus Tumor with Atypical Neuritis Presentation. ( 30116673 )
2018
15
Intravascular Glomus Tumor of the Wrist Causing Chronic Wrist Pain. ( 30154627 )
2018
16
Glomus tumor: a comprehensive review of the clinical and histopathologic features with report of two intraoral cases. ( 30243917 )
2018
17
The glomus tumor resorbed bone and teeth in the mandible: a case report. ( 30253798 )
2018
18
Glomus tumor in the floor of the mouth: a case report and review of the literature. ( 30305096 )
2018
19
A painless glomus tumor: a case report. ( 30333057 )
2018
20
Glomus tumor of the stomach: A case report. ( 30407338 )
2018
21
Central Airway Obstruction Due to Tracheal Glomus Tumor. ( 30464882 )
2018
22
Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF. ( 30556047 )
2018
23
Intra-Articular Glomus Tumor- A Rare Presentation. ( 28272676 )
2017
24
Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. ( 28438258 )
2017
25
An Extradigital Glomus Tumor of the Median Antebrachial Vein. ( 28888573 )
2017
26
Intravenous Glomus Tumor Masquerading as Lateral Antebrachial Cutaneous Neuroma. ( 28344537 )
2017
27
Unusual Volar Pulp Location of Glomus Tumor. ( 28203512 )
2017
28
Glomus Tumor of the Toe. ( 28650755 )
2017
29
HAS A GLOMUS TUMOR ALWAYS A QUICK DIAGNOSIS? ( 29446307 )
2017
30
Malignant Glomus Tumor of the Kidney. ( 28262221 )
2017
31
Nonintubated Spontaneous Respiration Anesthesia for Tracheal Glomus Tumor. ( 28734442 )
2017
32
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28141650 )
2017
33
Extradigital glomus tumor of the elbow with preoperative ultrasound-guided wire localization: a case report. ( 28941972 )
2017
34
An incidental finding of an asymptomatic intraneural glomus tumor: A case report and review of the literature. ( 29272030 )
2017
35
Successful Resection of locally infiltrative Glomus Tumor without pulmonary resection. ( 29096341 )
2017
36
Glomus Tumor of the Scrotum: A Case Report and Mini-Review. ( 29234266 )
2017
37
[Primary tracheal malignant glomus tumor with lung metastasis diagnosed by pathological analysis: a case report and literature review]. ( 28910916 )
2017
38
Micrometastatic Gastric Glomus Tumor Confirmed by Next-Generation Sequencing. ( 28675515 )
2017
39
Ultrasound-Guided, Minimally Invasive Resection of a Digital Glomus Tumor. ( 29108647 )
2017
40
Glomus Tumor in the Tarsal Tunnel: A Case Report. ( 28633794 )
2017
41
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
42
A gastric glomus tumor resected using non-exposed endoscopic wall-inversion surgery. ( 29039113 )
2017
43
A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor. ( 27931523 )
2017
44
Breast Cancer Metastasis on the Neck Mimicking a Glomus Tumor. ( 28468218 )
2017
45
Subungual onychomycosis due to<i>Aspergillus niger</i>mimicking a glomus tumor: A case report. ( 29188057 )
2017
46
Transducing-Like Enhancer of Split 1: A Potential Immunohistochemical Marker for Glomus Tumor. ( 28632567 )
2017
47
Atypically localized glomus tumor causing anterior interosseous nerve syndrome: A case report. ( 29056390 )
2017
48
Unusual imaging presentation of spinal glomus tumor: case report. ( 29354753 )
2017
49
Glomus Tumor of the Larynx: A Rare Synchronous Paraganglioma in a Patient with Bilateral Carotid Body Tumor Detected on (68)Ga-DOTANOC PET/CT. ( 28680217 )
2017
50
Glomus Tumor of the Sciatic Nerve: An Extraspinal Cause of Sciatica. ( 28934536 )
2017

Variations for Glomus Tumor

Expression for Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for Glomus Tumor

GO Terms for Glomus Tumor

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.16 SDHB SDHD
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 9.16 SYP TP53
2 ubiquinone binding GO:0048039 8.96 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Glomus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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