MCID: GLM008
MIFTS: 44

Glomus Tumor

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Glomus Tumor

MalaCards integrated aliases for Glomus Tumor:

Name: Glomus Tumor 12 60 56 45 15 74
Glomus Neoplasm 12
Glomus Tumour 12

Characteristics:

Orphanet epidemiological data:

60
glomus tumor
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:2431
MeSH 45 D005918
NCIt 51 C3060
SNOMED-CT 69 10438002
ICD10 via Orphanet 35 D18.0
UMLS via Orphanet 75 C0017653
Orphanet 60 ORPHA391651
UMLS 74 C0017653

Summaries for Glomus Tumor

Disease Ontology : 12 A hemangiopericytic tumor that is a mesenchymal neoplasm composed of cells that closely resemble the modified smooth muscle cells of the normal glomus body.

MalaCards based summary : Glomus Tumor, also known as glomus neoplasm, is related to glomangioma and paragangliomas 1. An important gene associated with Glomus Tumor is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Carbon metabolism. The drugs Doxorubicin and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, lung and trachea, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 77 A glomus tumor (also known as a "solitary glomus tumor," "solid glomus tumor,") is a rare neoplasm... more...

Related Diseases for Glomus Tumor

Diseases related to Glomus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 glomangioma 33.2 ACTC1 DES
2 paragangliomas 1 32.8 SDHB SDHD
3 hemangiopericytoma, malignant 30.5 ACTC1 DES VIM
4 glomangiomyoma 30.5 ACTC1 VIM
5 carcinoid syndrome 30.0 ENO2 SYP
6 fibromatosis 29.9 ACTC1 DES VIM
7 hemangioma 29.9 ACTC1 ENO2 SYP
8 chondroma 29.7 ACTC1 SDHB SDHD
9 paraganglioma 29.7 ENO2 SDHB SDHD SYP
10 spiradenoma 29.7 ACTC1 TP53
11 pleomorphic adenoma 29.6 ACTC1 TP53 VIM
12 dermatofibrosarcoma protuberans 29.2 ACTC1 DES TP53 VIM
13 merkel cell carcinoma 29.2 ENO2 SYP TP53
14 teratoma 29.0 ACTC1 ENO2 SYP TP53
15 leiomyosarcoma 28.9 ACTC1 DES ENO2 TP53 VIM
16 gastrointestinal stromal tumor 27.6 ACTC1 DES ENO2 SDHB SDHD SYP
17 subungual glomus tumor 12.4
18 skin glomus tumor 12.3
19 glomangiosarcoma 12.0
20 glomuvenous malformations 11.7
21 paragangliomas 2 11.4
22 paragangliomas 3 11.4
23 glomangiomatosis 11.2
24 myoepithelioma 10.4 ACTC1 VIM
25 dendritic cell tumor 10.4 ACTC1 VIM
26 polymorphous low-grade adenocarcinoma 10.4 ACTC1 VIM
27 mesenchymal chondrosarcoma 10.4 DES VIM
28 pleomorphic liposarcoma 10.4 DES VIM
29 angiomyolipoma 10.3 ACTC1 DES
30 oncocytoma 10.3 SYP VIM
31 fasciitis 10.3 ACTC1 DES
32 ischemic fasciitis 10.3 ACTC1 DES
33 neurofibromatosis, type iv, of riccardi 10.3
34 familial isolated dilated cardiomyopathy 10.3 ACTC1 DES
35 fibrolamellar carcinoma 10.3 SYP VIM
36 lymphangiectasis 10.3 ACTC1 VIM
37 anaplastic ependymoma 10.3 SYP VIM
38 lymphangioma 10.3 ACTC1 VIM
39 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
40 binswanger's disease 10.3 ACTC1 SYP
41 infantile digital fibromatosis 10.3 DES VIM
42 lymphangiomatosis 10.3 DES VIM
43 ovarian fibrothecoma 10.3 ACTC1 DES
44 fibroblastic rheumatism 10.3 ACTC1 DES
45 sertoli cell tumor 10.3 SYP VIM
46 cutaneous leiomyosarcoma 10.3 ACTC1 DES
47 botryoid rhabdomyosarcoma 10.3 ACTC1 DES
48 primary hepatic neuroendocrine carcinoma 10.2 SYP VIM
49 adenofibroma 10.2 ACTC1 VIM
50 biphasic synovial sarcoma 10.2 DES VIM

Graphical network of the top 20 diseases related to Glomus Tumor:



Diseases related to Glomus Tumor

Symptoms & Phenotypes for Glomus Tumor

MGI Mouse Phenotypes related to Glomus Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 DES ENO2 SDHD SYP TP53 VIM
2 cardiovascular system MP:0005385 9.02 ACTC1 DES SDHD TP53 VIM

Drugs & Therapeutics for Glomus Tumor

Drugs for Glomus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6
Doxil Approved June 1999 Phase 2, Phase 3 31703
7 Topoisomerase Inhibitors Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3
11 Alkylating Agents Phase 2, Phase 3
12
Isophosphamide mustard Phase 2, Phase 3 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
2 Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies Recruiting NCT03422679 Phase 1, Phase 2 CB-103

Search NIH Clinical Center for Glomus Tumor

Cochrane evidence based reviews: glomus tumor

Genetic Tests for Glomus Tumor

Anatomical Context for Glomus Tumor

MalaCards organs/tissues related to Glomus Tumor:

42
Smooth Muscle, Lung, Trachea, Kidney, Breast, Ovary, Liver

Publications for Glomus Tumor

Articles related to Glomus Tumor:

(show top 50) (show all 646)
# Title Authors Year
1
Synchronous primary glomus tumor in a patient with adenocarcinoma of the ipsilateral lung. ( 30951255 )
2019
2
Glomus tumor: a comprehensive review of the clinical and histopathologic features with report of two intraoral cases. ( 30243917 )
2019
3
Glomus tumor of the stomach treated by laparoscopic distal gastrectomy: A case report. ( 30655795 )
2019
4
Gastrointestinal: Glomus tumor: A rare submucosal tumor of the stomach. ( 30665269 )
2019
5
Rare malignant glomus tumor of the stomach with liver metastases. ( 30766648 )
2019
6
Behavior of primary tracheal glomus tumor, uncertain malignant potential subtype. ( 30799520 )
2019
7
Glomus Tumor of the Oral Cavity: Report of a Rare Case and Literature Review. ( 30970063 )
2019
8
Dermoscopy of Glomus Tumor. ( 30984607 )
2019
9
Malignant glomus tumor of the thyroid gland: a case report. ( 31039649 )
2019
10
Glomus tumor of the fingertips: A frequently missed diagnosis. ( 31041222 )
2019
11
A rare location of the glomus tumor in the abdominal aorta. ( 31065614 )
2019
12
Minimally invasive resection of a glomus tumor of the thoracic spine: a case report and literature review. ( 31079513 )
2019
13
Glomus Tumor of the Stomach-A Tumor That Needs to Be Differentiated From Gastrointestinal Stromal Tumor. ( 28501534 )
2018
14
An incidental finding of an asymptomatic intraneural glomus tumor: A case report and review of the literature. ( 29272030 )
2018
15
A case of gastric glomus tumor resection using laparoscopy endoscopy cooperative surgery (LECS). ( 29275234 )
2018
16
A case of a glomus tumor presenting as an atypical hyperkeratotic papule of the hypothenar palm. ( 29296650 )
2018
17
The usefulness of nail plate and intraoperative dermoscopy in subungual glomus tumor. ( 29318590 )
2018
18
Preoperative arterial embolization of endobronchial glomus tumor before endoscopic removal. ( 29609902 )
2018
19
Glomus tumor with rare clinical presentation as chronic shoulder pain. ( 29643719 )
2018
20
Rupture of a subungual glomus tumor of the finger. ( 29720134 )
2018
21
Glomus tumor of the stomach. ( 29756111 )
2018
22
Gastric Glomus Tumor: An Uncommon Source for an Acute Upper GI Bleed. ( 29862096 )
2018
23
Extradigital glomus tumor mimicking osteomuscular disease. ( 29924235 )
2018
24
Rare tumor in unusual location - glomus tumor of the finger pulp (clinical and dermoscopic features): a case report. ( 29981581 )
2018
25
Nail Unit Glomus Tumor with Myxoid and Symplastic Change Presenting with Longitudinal Erythronychia. ( 29998102 )
2018
26
Extradigital Glomus Tumor with Atypical Neuritis Presentation. ( 30116673 )
2018
27
Intravascular Glomus Tumor of the Wrist Causing Chronic Wrist Pain. ( 30154627 )
2018
28
The glomus tumor resorbed bone and teeth in the mandible: a case report. ( 30253798 )
2018
29
Glomus tumor in the floor of the mouth: a case report and review of the literature. ( 30305096 )
2018
30
A painless glomus tumor: a case report. ( 30333057 )
2018
31
Glomus tumor of the stomach: A case report. ( 30407338 )
2018
32
Central Airway Obstruction Due to Tracheal Glomus Tumor. ( 30464882 )
2018
33
Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF. ( 30556047 )
2018
34
A Rare Case of Glomus Tumor of the Thigh with Literature Review. ( 30740368 )
2018
35
Glomus tumor of the leg: a case report. ( 31065324 )
2018
36
Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review. ( 28106242 )
2018
37
An Extradigital Glomus Tumor of the Median Antebrachial Vein. ( 28888573 )
2018
38
Glomus Tumor of the Sciatic Nerve: An Extraspinal Cause of Sciatica. ( 28934536 )
2018
39
Ultrasound-Guided, Minimally Invasive Resection of a Digital Glomus Tumor. ( 29108647 )
2018
40
Rare presentation of the glomus tumor in the stomach. ( 29221662 )
2018
41
A blue middle ear mass: Cholesterol granuloma mimicking a glomus tumor and endolymphatic sac tumor. ( 27931523 )
2017
42
Glomangioma of the Kidney: A Rare Case of Glomus Tumor and Review of the Literature. ( 28698815 )
2017
43
Glomus Tumor of the Scrotum: A Case Report and Mini-Review. ( 29234266 )
2017
44
Glomus tumor as a cause of oncogenic osteomalacia. ( 29354168 )
2017
45
Unusual imaging presentation of spinal glomus tumor: case report. ( 29354753 )
2017
46
HAS A GLOMUS TUMOR ALWAYS A QUICK DIAGNOSIS? ( 29446307 )
2017
47
Malignant Glomus Tumor of the Kidney: A Case Report and Review of the Literature. ( 27349133 )
2017
48
Long-term survival case of malignant glomus tumor mimicking "dumbbell-shaped" neurogenic tumor. ( 27421277 )
2017
49
Sonographic diagnosis of a glomus tumor of the thigh. ( 27444193 )
2017
50
"Longitudinal hyperkeratotic structure" related to subungual glomus tumor. ( 27542925 )
2017

Variations for Glomus Tumor

Expression for Glomus Tumor

Search GEO for disease gene expression data for Glomus Tumor.

Pathways for Glomus Tumor

GO Terms for Glomus Tumor

Cellular components related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.16 SDHB SDHD
2 intermediate filament organization GO:0045109 8.96 DES VIM
3 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Glomus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 9.16 SYP TP53
2 ubiquinone binding GO:0048039 8.96 SDHB SDHD
3 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Glomus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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