MCID: GLS007
MIFTS: 48

Glossitis

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Glossitis

MalaCards integrated aliases for Glossitis:

Name: Glossitis 12 29 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1456
ICD10 33 K14.0
ICD9CM 35 529.0
MeSH 44 D005928
NCIt 50 C112199
SNOMED-CT 68 45534005
UMLS 73 C0017675

Summaries for Glossitis

MalaCards based summary : Glossitis is related to median rhomboid glossitis and cheilitis, and has symptoms including glossalgia An important gene associated with Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. The drugs leucovorin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include tongue, lung and bone, and related phenotypes are digestive/alimentary and integument

Wikipedia : 76 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

Related Diseases for Glossitis

Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 median rhomboid glossitis 33.6 KRT17 KRT6A KRT6B TTR
2 cheilitis 30.2 KRT6A TNF
3 burning mouth syndrome 29.8 IL6 TNF
4 pachyonychia congenita 1 29.8 KRT17 KRT6A KRT6B
5 gingivitis 29.7 IL1B IL6 TNF
6 haemophilus influenzae 29.7 IL1B TNF
7 psoriasis 29.7 IL1B IL6 KRT17 TNF
8 leishmaniasis 29.6 IL1B IL6 TNF
9 aphthous stomatitis 29.4 IL1B IL6 TNF
10 pneumonia 29.4 IL1B IL6 TNF
11 viral infectious disease 29.4 IL1B IL6 TNF
12 atrophic glossitis 12.3
13 geographic tongue 12.1
14 plummer vinson syndrome 11.4
15 methylmalonic aciduria and homocystinuria, cblf type 11.0
16 tongue disease 11.0
17 hypertrichosis lanuginosa, acquired 11.0
18 stomatitis 10.3
19 fissured tongue 10.2
20 pachyonychia congenita 2 10.1 KRT17 KRT6B
21 epidermoid cysts 10.1 KRT17 KRT6A
22 chronic pulmonary heart disease 10.1 TNF TTR
23 melioidosis 10.1 IL6 TNF
24 exanthem 10.1 IL6 TNF
25 rheumatic heart disease 10.1 IL6 TNF
26 infective endocarditis 10.1 IL6 TNF
27 hemorrhagic fever with renal syndrome 10.1 IL6 TNF
28 paracoccidioidomycosis 10.1 IL6 TNF
29 echinococcosis 10.1 IL6 TNF
30 rheumatic fever 10.1 IL6 TNF
31 uveal disease 10.1 IL6 TNF
32 mixed connective tissue disease 10.1 IL6 TNF
33 avian influenza 10.1 IL6 TNF
34 fasciitis 10.1 IL6 TNF
35 rasmussen encephalitis 10.1 IL6 TNF
36 deficiency anemia 10.1
37 vitamin b12 deficiency 10.1
38 dermatitis 10.1
39 syphilis 10.1
40 myelitis 10.1 IL6 TNF
41 scorpion envenomation 10.1 IL6 TNF
42 leukomalacia 10.1 IL6 TNF
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL6 TNF
44 critical limb ischemia 10.0 IL6 TNF
45 limb ischemia 10.0 IL6 TNF
46 streptococcal toxic-shock syndrome 10.0 IL6 TNF
47 juvenile ankylosing spondylitis 10.0 IL6 TNF
48 cardiogenic shock 10.0 IL6 TNF
49 null-cell leukemia 10.0 IL6 TNF
50 retinitis pigmentosa 55 10.0 IL6 TNF

Comorbidity relations with Glossitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Oral Candidiasis

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to Glossitis

Symptoms & Phenotypes for Glossitis

UMLS symptoms related to Glossitis:


glossalgia

MGI Mouse Phenotypes related to Glossitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 IL6 KRT17 KRT6B TNF TTR
2 integument MP:0010771 9.02 IL1B IL6 KRT17 KRT6B TNF

Drugs & Therapeutics for Glossitis

Drugs for Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4,Not Applicable 58-05-9 6006 143
2
Doxycycline Approved, Investigational, Vet_approved Phase 4,Not Applicable 564-25-0 54671203
3
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
6
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
7
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
9 Vitamin B9 Phase 4,Not Applicable
10 Vitamin B Complex Phase 4,Not Applicable
11 Folate Phase 4,Not Applicable
12 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
13 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
14 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
15 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
16 Antimalarials Phase 4,Not Applicable
17 cefuroxime axetil Phase 4,Not Applicable
18 penicillins Phase 4
19 Antibiotics, Antitubercular Phase 4,Not Applicable
20 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
21 Renal Agents Phase 4,Phase 3
22 Anti-Infective Agents, Urinary Phase 4,Phase 3
23 Estrogens Phase 4
24 Folic Acid Antagonists Phase 4
25 Anti-Infective Agents, Local Phase 4
26 Methenamine hippurate Phase 4
27
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
28
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
29
Ofloxacin Approved Phase 3 82419-36-1 4583
30
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
31
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
32 Anti-Ulcer Agents Phase 3
33 Alkylating Agents Phase 3
34 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
35 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
36 Antacids Phase 3
37 Proton Pump Inhibitors Phase 3
38 Gastrointestinal Agents Phase 3
39 Topoisomerase Inhibitors Phase 3
40
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
41
Iron Approved Not Applicable 7439-89-6 23925
42
Ceftriaxone Approved Not Applicable 73384-59-5 5479530 5361919
43
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
44
Cobalamin Experimental Not Applicable 13408-78-1 6438156
45 Trace Elements Not Applicable
46 Immunologic Factors Not Applicable
47 Vitamin B 12 Not Applicable
48 Autoantibodies Not Applicable
49 Micronutrients Not Applicable
50 Hematinics Not Applicable

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs Active, not recruiting NCT03077711 Phase 4 Trimethoprim;Methenamine hippurate
4 5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection Completed NCT01544517 Phase 3 Eradication therapy (amoxicillin; esomeprazole; tinidazole; levofloxacin)
5 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable
6 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
7 Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans Completed NCT03584919 Not Applicable doxycycline;Cefuroxime Axetil 500Mg Tab
8 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 Not Applicable doxycycline;doxycycline;placebo
9 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754 Not Applicable
10 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
11 Analysis of Lyme Disease Lesions Completed NCT00132327
12 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809
13 Patient's Pretreatment Expectations About Post-Lyme Symptoms Recruiting NCT03462329 Not Applicable Antibiotics (preferentially oral doxycycline 100 mg bid)
14 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 Not Applicable antibiotic treatment
15 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 Not Applicable ceftriaxone;doxycycline
16 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789 Not Applicable
17 Next Generation Sequencing Detection of Lyme Disease Recruiting NCT03505879
18 Erythema Migrans in Elderly Active, not recruiting NCT03371563 Antibiotics

Search NIH Clinical Center for Glossitis

Cochrane evidence based reviews: glossitis

Genetic Tests for Glossitis

Genetic tests related to Glossitis:

# Genetic test Affiliating Genes
1 Glossitis 29

Anatomical Context for Glossitis

MalaCards organs/tissues related to Glossitis:

41
Tongue, Lung, Bone, Heart, Monocytes, Skin, Lymph Node

Publications for Glossitis

Articles related to Glossitis:

(show top 50) (show all 242)
# Title Authors Year
1
Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis. ( 29572125 )
2018
2
Benign Migratory Glossitis. ( 29394988 )
2018
3
Benign Migratory Glossitis. ( 29110980 )
2018
4
Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. ( 29653880 )
2018
5
Significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients. ( 30087017 )
2018
6
Treatment of symptomatic benign migratory glossitis: a systematic review. ( 29982968 )
2018
7
The Effect of Zinc Gluconate Supplementation on Symptoms and Tongue Epithelium Regeneration in Non-psoriatic Patients with Migratory Glossitis. ( 29989868 )
2018
8
Particular shape of the tongue and benign migratory glossitis. ( 30167039 )
2018
9
Anemia in Pregnancy Presenting as Acute Glossitis. ( 30244997 )
2018
10
Mycobacterium abscessus glossitis. ( 28948933 )
2017
11
Fungal dermatitis, glossitis and disseminated visceral mycosis caused by different Metarhizium granulomatis genotypes in veiled chameleons (Chamaeleo calyptratus) and first isolation in healthy lizards. ( 28757044 )
2017
12
Isolation of Avipoxvirus from Tongue of Canaries ( Serinus canaria) Show Severe Localized Proliferative Glossitis. ( 29337622 )
2017
13
Host and clinical aspects in patients with benign migratory glossitis. ( 27810384 )
2017
14
The Candida species that are important for the development of atrophic glossitis in xerostomia patients. ( 29246167 )
2017
15
Rhomboid glossitis in disseminated CMV infection. ( 28331808 )
2017
16
Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population. ( 29364438 )
2017
17
A Rare Case of Glossitis due to Pasteurella multocida after a Cat Scratch. ( 27840749 )
2016
18
Rhomboid glossitis caused by candida? ( 27200118 )
2016
19
Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis. ( 27755675 )
2016
20
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
21
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
22
Waxing and waning eczematous dermatitis andA glossitis. ( 25773429 )
2015
23
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
24
Fungiform papillary glossitis. ( 24581085 )
2014
25
Environmental factors in benign migratory glossitis and psoriasis: Retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis. ( 25073550 )
2014
26
Matched case-control study to examine association of psoriasis and migratory glossitis in India. ( 23254730 )
2013
27
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
28
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
29
Glossitis secondary to vitamin B12 deficiency anemia. ( 23359038 )
2013
30
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. ( 24060545 )
2013
31
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
32
Clinical pathologic conference case 5: Unusual severe glossitis. ( 23738346 )
2013
33
Benign migratory glossitis. ( 24413515 )
2013
34
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
35
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
36
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. ( 22918478 )
2012
37
An apple a day ... chronic glossitis in a 4-year-old boy. ( 22768729 )
2012
38
Benign migratory glossitis with fissured tongue. ( 22918106 )
2012
39
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
40
The development and inflammatory features of radiotherapy-induced glossitis in rats. ( 21196832 )
2011
41
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
42
Median rhomboid glossitis. ( 21446620 )
2011
43
The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model. ( 21196860 )
2011
44
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. ( 21802154 )
2011
45
Oral pathology. Benign migratory glossitis. ( 20806635 )
2010
46
Predisposition of allergy in patients with benign migratory glossitis. ( 20674406 )
2010
47
Herpetic geometric glossitis: acyclovir resistant case in a patient with acute myelogenous leukemia. ( 20090244 )
2010
48
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
49
Glossitis with linear lesions: an early sign of vitamin B12 deficiency. ( 19231648 )
2009
50
A classic case of median rhomboid glossitis. ( 19601454 )
2009

Variations for Glossitis

Expression for Glossitis

Search GEO for disease gene expression data for Glossitis.

Pathways for Glossitis

Pathways related to Glossitis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1 12.35 KRT17 KRT6A KRT6B
2
Show member pathways
12.31 KRT17 KRT6A KRT6B
3
Show member pathways
12.26 IL1B IL6 TNF
4
Show member pathways
12.18 IL1B IL6 TNF
5
Show member pathways
12.17 IL1B IL6 TNF
6
Show member pathways
12.14 IL1B IL6 TNF
7 12.08 IL1B IL6 TNF
8
Show member pathways
12.06 IL1B IL6 TNF
9
Show member pathways
12.05 IL1B IL6 TNF
10
Show member pathways
12.02 IL1B IL6 TNF
11 12.01 IL1B IL6 TNF
12
Show member pathways
11.9 IL1B IL6 TNF
13
Show member pathways
11.88 IL1B IL6 TNF
14 11.85 IL1B IL6 TNF
15 11.82 IL1B IL6 TNF
16 11.8 IL1B IL6 TNF
17 11.75 IL1B IL6 TNF
18 11.73 IL1B IL6 TNF
19 11.72 IL1B IL6 TNF
20 11.68 IL1B IL6 TNF
21 11.59 IL1B IL6 TNF
22 11.57 IL1B IL6 TNF
23 11.54 IL1B IL6 TNF
24 11.47 IL1B IL6 TNF
25
Show member pathways
11.45 IL1B IL6 TNF
26 11.38 IL6 TNF
27 11.37 IL1B TNF
28 11.37 IL1B IL6
29 11.37 IL1B TNF
30 11.37 IL1B IL6 TNF
31
Show member pathways
11.32 IL1B TNF
32 11.3 IL1B IL6 TNF
33 11.27 IL1B IL6 TNF
34 11.22 IL1B IL6
35 11.2 IL1B IL6 TNF
36 11.07 IL1B IL6 TNF
37 11.04 IL1B IL6 TNF
38 11 IL1B TNF
39 10.99 IL6 TNF
40 10.98 IL1B IL6 TNF
41 10.91 IL6 TNF
42 10.84 IL1B IL6 TNF
43 10.82 IL1B TNF
44 10.62 IL1B IL6 TNF
45 10.26 IL1B IL6 TNF

GO Terms for Glossitis

Cellular components related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT17 KRT6A KRT6B

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.87 IL1B IL6 TNF TTR
2 cytokine-mediated signaling pathway GO:0019221 9.84 IL1B IL6 TNF
3 keratinization GO:0031424 9.8 KRT17 KRT6A KRT6B
4 cytoskeleton organization GO:0007010 9.79 KRT17 KRT6A KRT6B
5 cellular response to lipopolysaccharide GO:0071222 9.79 IL1B IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 IL1B IL6 TNF
7 cornification GO:0070268 9.73 KRT17 KRT6A KRT6B
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 IL1B IL6 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.7 IL6 KRT6A TNF
10 negative regulation of fat cell differentiation GO:0045599 9.67 IL6 TNF
11 positive regulation of interferon-gamma production GO:0032729 9.67 IL1B TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.66 IL1B TNF
13 positive regulation of JUN kinase activity GO:0043507 9.65 IL1B TNF
14 positive regulation of phagocytosis GO:0050766 9.65 IL1B TNF
15 protein kinase B signaling GO:0043491 9.65 IL1B TNF
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.64 IL1B TNF
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.64 IL1B TNF
18 positive regulation of interleukin-8 production GO:0032757 9.63 IL1B TNF
19 positive regulation of chemokine production GO:0032722 9.62 IL6 TNF
20 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
21 response to glucocorticoid GO:0051384 9.61 IL1B IL6 TNF
22 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.6 IL1B TNF
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IL1B TNF
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL1B TNF
25 positive regulation of interleukin-6 production GO:0032755 9.58 IL1B IL6 TNF
26 negative regulation of lipid storage GO:0010888 9.54 IL6 TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.51 IL1B TNF
28 positive regulation of hair follicle development GO:0051798 9.49 KRT17 TNF
29 regulation of establishment of endothelial barrier GO:1903140 9.48 IL1B TNF
30 positive regulation of fever generation GO:0031622 9.46 IL1B TNF
31 chronic inflammatory response to antigenic stimulus GO:0002439 9.37 IL1B TNF
32 negative regulation of neurogenesis GO:0050768 9.33 IL1B IL6 TNF
33 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
35 positive regulation of glial cell proliferation GO:0060252 9.13 IL1B IL6 TNF
36 positive regulation of neuroinflammatory response GO:0150078 8.8 IL1B IL6 TNF

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL6 TNF
2 structural constituent of cytoskeleton GO:0005200 8.8 KRT17 KRT6A KRT6B

Sources for Glossitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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