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MCID: GLS007
MIFTS: 45

Glossitis

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Glossitis

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MalaCards integrated aliases for Glossitis:

Name: Glossitis 12 29 44 15 73

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:1456
ICD10 33 K14.0
ICD9CM 35 529.0
MeSH 44 D005928
NCIt 50 C112199
UMLS 73 C0017675
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Summaries for Glossitis

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MalaCards based summary : Glossitis is related to tongue disease and median rhomboid glossitis, and has symptoms including glossalgia An important gene associated with Glossitis is KRT6B (Keratin 6B), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. The drugs Doxycycline and Penicillin V have been mentioned in the context of this disorder. Affiliated tissues include tongue, thyroid and monocytes, and related phenotype is integument.

Wikipedia : 76 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

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Related Diseases for Glossitis

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Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 tongue disease 32.2 KRT6A KRT6B
2 median rhomboid glossitis 31.7 KRT16 KRT17 KRT6A KRT6B TTR
3 fissured tongue 30.5 KRT16 KRT6A
4 burns 29.7 IL1B TTR
5 aphthous stomatitis 29.3 IL1B IL6
6 gingivitis 29.2 IL1B IL6
7 pachyonychia congenita 1 28.4 KRT16 KRT17 KRT6A KRT6B
8 psoriasis 28.0 IL1B IL6 KRT16 KRT17
9 atrophic glossitis 12.2
10 geographic tongue 11.9
11 plummer vinson syndrome 11.2
12 methylmalonic aciduria and homocystinuria, cblf type 10.9
13 hypertrichosis lanuginosa, acquired 10.9
14 epidermoid cysts 10.4 KRT17 KRT6A
15 protein-energy malnutrition 10.3 IL6 TTR
16 tinea corporis 10.2 KRT16 KRT17
17 steatocystoma multiplex 10.2 KRT16 KRT17
18 bowen's disease 10.2 KRT16 KRT17
19 stomatitis 10.2
20 palmoplantar keratoderma, epidermolytic 10.2 KRT16 KRT17
21 palmoplantar keratoderma, nonepidermolytic 10.1 KRT16 KRT17
22 obstructive jaundice 10.1 IL6 TTR
23 keratoacanthoma 10.1 KRT16 KRT17
24 primary cutaneous amyloidosis 10.0 KRT16 KRT17
25 aging 10.0
26 cheilitis 10.0
27 epidermolytic hyperkeratosis 10.0 KRT16 KRT17
28 recurrent corneal erosion 9.9 IL1B IL6
29 bagassosis 9.9 IL1B IL6
30 periodontitis, chronic 9.9 IL1B IL6
31 uremic pruritus 9.9 IL1B IL6
32 funisitis 9.9 IL1B IL6
33 euthyroid sick syndrome 9.9 IL1B IL6
34 laryngitis 9.9 IL1B IL6
35 ascaris lumbricoides infection 9.9 IL1B IL6
36 acute vascular insufficiency of intestine 9.9 IL1B IL6
37 poems syndrome 9.9 IL1B IL6
38 periapical periodontitis 9.9 IL1B IL6
39 central nervous system vasculitis 9.9 IL1B IL6
40 vitamin b12 deficiency 9.9
41 dermatitis 9.9
42 syphilis 9.9
43 osteosclerotic myeloma 9.9 IL1B IL6
44 stachybotrys chartarum 9.9 IL1B IL6
45 vaginal disease 9.9 IL1B IL6
46 endometrial disease 9.9 IL1B IL6
47 cysticercosis 9.9 IL1B IL6
48 vaginitis 9.9 IL1B IL6
49 primary amebic meningoencephalitis 9.9 IL1B IL6
50 hydrarthrosis 9.9 IL1B IL6

Comorbidity relations with Glossitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Oral Candidiasis

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to Glossitis
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Symptoms & Phenotypes for Glossitis

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UMLS symptoms related to Glossitis:


glossalgia

MGI Mouse Phenotypes related to Glossitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 IL1B IL6 KRT16 KRT17 KRT6B
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Drugs & Therapeutics for Glossitis

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Drugs for Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Not Applicable 564-25-0 54671203
2
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
3
Cefuroxime Approved Phase 4,Not Applicable 55268-75-2 5361202 5479529
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
5
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
6
Methenamine Approved, Vet_approved Phase 4 100-97-0 4101
7
leucovorin Approved, Nutraceutical Phase 4,Not Applicable 58-05-9 143 6006
8
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
9 Vitamin B Complex Phase 4,Not Applicable
10 penicillins Phase 4
11 cefuroxime axetil Phase 4,Not Applicable
12 Renal Agents Phase 4,Phase 3
13 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
14 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
15 Antibiotics, Antitubercular Phase 4,Not Applicable
16 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
17 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
18 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
19 Antimalarials Phase 4,Not Applicable
20 Methenamine hippurate Phase 4
21 Folic Acid Antagonists Phase 4
22 Estrogens Phase 4
23 Anti-Infective Agents, Local Phase 4
24 Folate Nutraceutical Phase 4,Not Applicable
25 Vitamin B9 Nutraceutical Phase 4,Not Applicable
26
Tinidazole Approved, Investigational Phase 3 19387-91-8 5479
27
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
28
Ofloxacin Approved Phase 3 82419-36-1 4583
29
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
30
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
31 Alkylating Agents Phase 3
32 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
33 Gastrointestinal Agents Phase 3
34 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
35 Topoisomerase Inhibitors Phase 3
36 Antacids Phase 3
37 Proton Pump Inhibitors Phase 3
38 Anti-Ulcer Agents Phase 3
39
Iron Approved Not Applicable 7439-89-6 23925
40
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
41
Ceftriaxone Approved Not Applicable 73384-59-5 5479530 5361919
42
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
43 Micronutrients Not Applicable
44 Hematinics Not Applicable
45 Trace Elements Not Applicable
46 Vitamin B 12 Not Applicable
47 Vitamins Not Applicable
48 Antibodies Not Applicable
49 Immunoglobulins Not Applicable
50 Autoantibodies Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
2 Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
3 Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs Recruiting NCT03077711 Phase 4 Trimethoprim;Methenamine hippurate
4 5 Day Concomitant Versus 10 Day Sequential Therapy for Eradication of H. Pylori Infection Completed NCT01544517 Phase 3 Eradication therapy (amoxicillin; esomeprazole; tinidazole; levofloxacin)
5 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable
6 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
7 Duration of Antibiotic Treatment of Erythema Migrans Completed NCT00910715 Not Applicable doxycycline;doxycycline;placebo
8 Culture Media for Borrelia Burgdorferi Sensu Lato Completed NCT02145754 Not Applicable
9 Doxycycline in Therapy of Erythema Migrans Completed NCT01475708 Doxycycline
10 Oral Lesions In Non-Celiac Wheat Sensitivity Patients Recruiting NCT02421809
11 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789 Not Applicable
12 Cytokines and Chemokines in Erythema Migrans Recruiting NCT02147249 Not Applicable antibiotic treatment
13 Antibiotic Treatment of Multiple Erythema Migrans Recruiting NCT01163994 Not Applicable ceftriaxone;doxycycline
14 Analysis of Lyme Disease Lesions Recruiting NCT00132327
15 Erythema Migrans in Elderly Active, not recruiting NCT03371563 Antibiotics
16 Patient's Pretreatment Expectations About Post-Lyme Symptoms Not yet recruiting NCT03462329 Not Applicable Antibiotics (preferentially oral doxycycline 100 mg bid)
17 Next Generation Sequencing Detection of Lyme Disease Not yet recruiting NCT03505879

Search NIH Clinical Center for Glossitis

Cochrane evidence based reviews: glossitis

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Genetic Tests for Glossitis

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Genetic tests related to Glossitis:

# Genetic test Affiliating Genes
1 Glossitis 29
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Anatomical Context for Glossitis

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MalaCards organs/tissues related to Glossitis:

41
Tongue, Thyroid, Monocytes, Endothelial, Lung, Liver, Bone
Sources

Publications for Glossitis

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Articles related to Glossitis:

(show top 50) (show all 225)
# Title Authors Year
1
Hemoglobin, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in Behcet's disease patients with atrophic glossitis. ( 29572125 )
2018
2
Benign Migratory Glossitis. ( 29394988 )
2018
3
Benign Migratory Glossitis. ( 29110980 )
2018
4
Gastric parietal cell and thyroid autoantibodies in Behcet's disease patients with or without atrophic glossitis. ( 29653880 )
2018
5
Mycobacterium abscessus glossitis. ( 28948933 )
2017
6
Fungal dermatitis, glossitis and disseminated visceral mycosis caused by different Metarhizium granulomatis genotypes in veiled chameleons (Chamaeleo calyptratus) and first isolation in healthy lizards. ( 28757044 )
2017
7
Isolation of Avipoxvirus from Tongue of Canaries ( Serinus canaria) Show Severe Localized Proliferative Glossitis. ( 29337622 )
2017
8
Host and clinical aspects in patients with benign migratory glossitis. ( 27810384 )
2017
9
The Candida species that are important for the development of atrophic glossitis in xerostomia patients. ( 29246167 )
2017
10
Rhomboid glossitis in disseminated CMV infection. ( 28331808 )
2017
11
Prevalence and heritability of psoriasis and benign migratory glossitis in one Brazilian population. ( 29364438 )
2017
12
A Rare Case of Glossitis due to Pasteurella multocida after a Cat Scratch. ( 27840749 )
2016
13
Rhomboid glossitis caused by candida? ( 27200118 )
2016
14
Nodular granulomatous glossitis as the sole clinical sign in canine leishmaniosis. ( 27755675 )
2016
15
Hematinic deficiencies and anemia statuses in recurrent aphthous stomatitis patients with or without atrophic glossitis. ( 27839675 )
2016
16
Median rhomboid glossitis-developmental or candidal? ( 26523164 )
2015
17
Waxing and waning eczematous dermatitis andA glossitis. ( 25773429 )
2015
18
Application of the novel method in the diagnosis and treatment of median rhomboid glossitis Candida-associated. ( 24966760 )
2014
19
Fungiform papillary glossitis. ( 24581085 )
2014
20
Environmental factors in benign migratory glossitis and psoriasis: Retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis. ( 25073550 )
2014
21
Matched case-control study to examine association of psoriasis and migratory glossitis in India. ( 23254730 )
2013
22
Diagnostic discussion. Median rhomboid glossitis (MRG). ( 24579425 )
2013
23
Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients. ( 23130817 )
2013
24
Glossitis secondary to vitamin B12 deficiency anemia. ( 23359038 )
2013
25
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines. ( 24060545 )
2013
26
Oral and maxillofacial pathology case of the month. Erythema migrans (ectopic migratory glossitis/ectopic geographic tongue). ( 24236384 )
2013
27
Clinical pathologic conference case 5: Unusual severe glossitis. ( 23738346 )
2013
28
Benign migratory glossitis. ( 24413515 )
2013
29
Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. ( 22188475 )
2012
30
Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. ( 22762365 )
2012
31
A case of possible glossitis in a patient with non small cell carcinoma of the lung secondary to levomepromazine. ( 22918478 )
2012
32
An apple a day ... chronic glossitis in a 4-year-old boy. ( 22768729 )
2012
33
Benign migratory glossitis with fissured tongue. ( 22918106 )
2012
34
The prevalence of median rhomboid glossitis in diabetic patients: a case-control study. ( 22737518 )
2011
35
The development and inflammatory features of radiotherapy-induced glossitis in rats. ( 21196832 )
2011
36
Median rhomboid glossitis: a clinical and microbiological study. ( 21912494 )
2011
37
Median rhomboid glossitis. ( 21446620 )
2011
38
The correlation between the severity of radiotherapy-induced glossitis and endothelial cell injury in local tissues in a rat model. ( 21196860 )
2011
39
Taste evaluation in adolescents and pediatric patients with benign migratory glossitis. ( 21802154 )
2011
40
Oral pathology. Benign migratory glossitis. ( 20806635 )
2010
41
Predisposition of allergy in patients with benign migratory glossitis. ( 20674406 )
2010
42
Herpetic geometric glossitis: acyclovir resistant case in a patient with acute myelogenous leukemia. ( 20090244 )
2010
43
Hyperplastic candidosis on the palate developed as a 'kissing' lesion from median rhomboid glossitis. ( 20339702 )
2010
44
Glossitis with linear lesions: an early sign of vitamin B12 deficiency. ( 19231648 )
2009
45
A classic case of median rhomboid glossitis. ( 19601454 )
2009
46
Unusual coexistence of oral lymphoepithelial cyst and benign migratory glossitis. ( 19575124 )
2009
47
The prevalence and risk factors associated with benign migratory glossitis lesions in 7619 Turkish dental outpatients. ( 19138635 )
2009
48
Herpetic geometric glossitis in an immunocompetent patient with pneumonia. ( 19539852 )
2009
49
Recurrent Trichosporon asahii glossitis: a case report. ( 18335127 )
2008
50
Primary tuberculous glossitis in an immunocompetent patient. ( 17664540 )
2007
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Variations for Glossitis

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Expression for Glossitis

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Search GEO for disease gene expression data for Glossitis.
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Pathways for Glossitis

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Pathways related to Glossitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
12.14 KRT17 KRT6A KRT6B
2
Keratinization 66
Show member pathways
 11.38 KRT16 KRT17 KRT6A KRT6B
3
Lung fibrosis 1
11.36 IL1B IL6
4
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.35 IL1B IL6
5
Legionellosis 37
11.28 IL1B IL6
6
Interleukin-10 signaling 66
11.21 IL1B IL6
7
Malaria 37
11.2 IL1B IL6
8
Hematopoietic Stem Cell Differentiation 1
11.18 IL1B IL6
9
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.17 KRT16 KRT17 KRT6A
10
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.11 IL1B IL6
11
African trypanosomiasis 37
10.98 IL1B IL6
12
IL-10 Pathway 64
10.95 IL1B IL6
13
Prion diseases 37
10.91 IL1B IL6
14
Development and heterogeneity of the ILC family 1
10.83 IL1B IL6
15
Antifolate resistance 37
10.75 IL1B IL6
16
Cytokines and Inflammatory Response 1
10.63 IL1B IL6
Sources

GO Terms for Glossitis

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Cellular components related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.43 IL1B KRT16 KRT17 KRT6A KRT6B TTR
2 intermediate filament GO:0005882 8.92 KRT16 KRT17 KRT6A KRT6B

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.5 KRT16 KRT6A KRT6B
2 positive regulation of T cell proliferation GO:0042102 9.43 IL1B IL6
3 positive regulation of interleukin-6 production GO:0032755 9.4 IL1B IL6
4 negative regulation of insulin receptor signaling pathway GO:0046627 9.37 IL1B LMBRD1
5 morphogenesis of an epithelium GO:0002009 9.26 KRT16 KRT6A
6 keratinization GO:0031424 9.26 KRT16 KRT17 KRT6A KRT6B
7 intermediate filament cytoskeleton organization GO:0045104 9.16 KRT16 KRT6A
8 cornification GO:0070268 8.92 KRT16 KRT17 KRT6A KRT6B

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT16 KRT17 KRT6A
2 structural constituent of cytoskeleton GO:0005200 8.92 KRT16 KRT17 KRT6A KRT6B
Sources

Sources for Glossitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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