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MCID: GLS007
MIFTS: 46

Glossitis

Categories: Gastrointestinal diseases, Oral diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Glossitis

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MalaCards integrated aliases for Glossitis:

Name: Glossitis 12 44 15 17 70 32

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1456
ICD9CM 34 529.0
MeSH 44 D005928
NCIt 50 C112199
SNOMED-CT 67 155666003
ICD10 32 K14.0
UMLS 70 C0017675
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Summaries for Glossitis

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MalaCards based summary : Glossitis is related to median rhomboid glossitis and atrophic glossitis, and has symptoms including glossalgia An important gene associated with Glossitis is IL6 (Interleukin 6), and among its related pathways/superpathways are Keratinization and Folate Metabolism. The drugs Cefuroxime and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and thyroid, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 73 Glossitis can mean soreness of the tongue, or more usually inflammation with depapillation of the dorsal... more...

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Related Diseases for Glossitis

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Diseases related to Glossitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 534)
# Related Disease Score Top Affiliating Genes
1 median rhomboid glossitis 32.2 KRT6B KRT6A KRT17 KRT16
2 atrophic glossitis 32.2 TTR IL36RN
3 stomatitis 31.1 TNF IL6 IL1B
4 pernicious anemia 31.0 TCN2 ATP4A ATP12A
5 fissured tongue 30.8 KRT6A KRT16
6 candidiasis 30.7 TNF IL6 IL1B
7 aphthous stomatitis 30.4 TNF IL6 IL1B
8 gingivitis 30.4 TNF IL6 IL1B
9 atrophic gastritis 30.4 TNF IL6 IL1B
10 pharyngitis 30.3 TNF IL6 IL1B
11 enterocolitis 30.3 TNF IL6
12 leishmaniasis 30.3 TNF IL6 IL1B
13 gastritis 30.2 TNF IL6 IL1B ATP4A
14 dermatitis 30.2 TNF KRT16 IL6 IL1B
15 lichen planus 30.2 TNF KRT16 IL6 IL1B
16 esophagitis 30.1 TNF IL6 IL1B
17 periodontitis 30.1 TNF IL6 IL1B
18 osteomyelitis 30.1 TNF IL6 IL1B
19 angular cheilitis 30.1 KRT6B KRT6A GCG
20 tonsillitis 30.1 TNF IL6 IL1B
21 toxic shock syndrome 30.0 TNF IL6 IL1B
22 mumps 30.0 TNF IL6 IL1B
23 endocarditis 30.0 TTR TNF IL6
24 burning mouth syndrome 30.0 TNF SLC6A4 IL6 IL1B
25 keratitis, hereditary 30.0 TNF IL6 IL1B
26 fabry disease 30.0 TNF IL6 IL1B
27 amyloidosis 29.8 TTR TNF IL6 IL1B
28 vitamin b12 deficiency 29.8 TCN2 LMBRD1 ATP4A ATP12A
29 alopecia areata 29.8 TNF KRT16 IL6 IL1B
30 pachyonychia congenita 1 29.6 KRT6B KRT6A KRT17 KRT16
31 psoriasis 29.6 TNF KRT17 KRT16 IL6 IL36RN IL1B
32 diarrhea 29.5 TTR TNF SLC6A4 IL6 IL1B
33 anxiety 29.5 TNF SLC6A4 IL6 IL1B COMT
34 deficiency anemia 29.3 TTR TNF TCN2 LMBRD1 IL6 ATP4A
35 exanthem 29.0 TNF IL6 IL1B ATP4A ATP12A
36 celiac disease 1 28.9 TNF IL6 IL1B GCG ATP4A ATP12A
37 skin disease 28.8 TNF KRT6A KRT17 KRT16 IL6 IL36RN
38 geographic tongue 11.5
39 plummer vinson syndrome 11.1
40 glucagonoma 10.9
41 methylmalonic aciduria and homocystinuria, cblf type 10.9
42 riboflavin deficiency 10.9
43 tongue disease 10.9
44 hypertrichosis lanuginosa, acquired 10.9
45 external pathological resorption 10.4 TNF IL6
46 scorpion envenomation 10.4 TNF IL6
47 idiopathic anterior uveitis 10.4 TNF IL6
48 streptococcal toxic-shock syndrome 10.4 TNF IL6
49 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
50 staphylococcal toxic shock syndrome 10.4 TNF IL1B

Comorbidity relations with Glossitis via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Heart Disease Oral Candidiasis

Graphical network of the top 20 diseases related to Glossitis:



Diseases related to Glossitis
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Symptoms & Phenotypes for Glossitis

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UMLS symptoms related to Glossitis:


glossalgia

MGI Mouse Phenotypes related to Glossitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.81 ATP12A ATP4A IL6 KRT16 KRT17 KRT6B
2 homeostasis/metabolism MP:0005376 9.73 ATP12A ATP4A COMT IL1B IL36RN IL6
3 integument MP:0010771 9.23 IL1B IL36RN IL6 KRT16 KRT17 KRT6B
Sources

Drugs & Therapeutics for Glossitis

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Drugs for Glossitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 cefuroxime axetil Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Antimalarials Phase 4
9 Antiparasitic Agents Phase 4
10 Antiprotozoal Agents Phase 4
11 penicillins Phase 4
12
Levoleucovorin Approved, Investigational 68538-85-2 149436
13
Iron Approved 7439-89-6 23925 29936
14
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
15
Ceftriaxone Approved 73384-59-5 5479530 5361919
16
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
17
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
18
Cobalamin Experimental 13408-78-1 6857388
19 Vitamin B9
20 Trace Elements
21 Nutrients
22 Hematinics
23 Vitamins
24 Antibodies
25 Immunoglobulins
26 Vitamin B Complex
27 Folate
28 Vitamin B12
29 Micronutrients
30 Vitamin B 12
31 Autoantibodies
32 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Tick Borne Diseases in Norwegian General Practice. A Randomized, Controlled Trial for Treatment of Erythema Migrans in Norwegian General Practice. A Comparison of Phenoxymethylpenicillin, Amoxicillin and Doxycycline. Completed NCT01368341 Phase 4 Doxycycline;Phenoxymethylpenicillin;Amoxicillin
2 Risk Factors for Failure of Erythema Migrans Treatment - Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Adult Patients With Erythema Migrans: Clinical and Microbiological Outcome. Completed NCT01518192 Phase 4 doxycycline;cefuroxime axetil
3 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293
4 The Relationship Between Allergic Rhinitis and Geographic Tongue Unknown status NCT01454492
5 Comparison of Ceftriaxone and Doxycycline for Treatment of Multiple Erythema Migrans Unknown status NCT01163994 ceftriaxone;doxycycline
6 Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans Unknown status NCT02147249 antibiotic treatment
7 Inflammatory Responses in Borrelia Afzelii Culture Positive Patients With Early Disseminated or Early Localized Lyme Borreliosis Completed NCT03980015
8 Doxycycline in Therapy of Erythema Migrans - do the Accompanying Symptoms Influence the Outcome? Completed NCT01475708 Doxycycline
9 Inflammatory Proteins, Gene Polymorphisms, and Transcriptome Profiles in Patients With Erythema Migrans Completed NCT03956212 Doxycycline 7 days;Doxycycline 14 days
10 Comparison of Doxycycline and Cefuroxime Axetil in Patients With Erythema Migrans Completed NCT03584919 doxycycline;Cefuroxime Axetil 500Mg Tab
11 Analysis of Erythema Migrans Lesions Completed NCT00132327
12 Clinical Course, Serologic Response and Long-term Outcome in Elderly Patients With Early Lyme Borreliosis Completed NCT03371563 Antibiotics
13 Comparison of Two Culture Media for Cultivation of Borrelia Burgdorferi Sensu Lato Completed NCT02145754
14 Duration of Antibiotic Treatment of Erythema Migrans. A Randomized Clinical Trial. Completed NCT00910715 doxycycline;doxycycline;placebo
15 Different Duration and Dosing of Amoxicillin in Patients With Erythema Migrans. A Randomized Clinical Trial. Recruiting NCT03966014 EM-amoxicillin 3 x 10 days;EM-amoxicillin 3 x 14 days;EM-amoxicillin 2 x 14 days
16 Next Generation Sequencing to Detect Borrelia Burgdorferi DNA in the Blood of Pediatric Patients With Lyme Disease Recruiting NCT03505879
17 Impact of Patient's Pretreatment Expectations on Treatment Outcome of Early Lyme Borreliosis Recruiting NCT03462329 Antibiotics (preferentially oral doxycycline 100 mg bid)
18 Lyme Borreliosis and Early Cutaneous Diagnostic Recruiting NCT02414789

Search NIH Clinical Center for Glossitis

Cochrane evidence based reviews: glossitis

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Genetic Tests for Glossitis

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Anatomical Context for Glossitis

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MalaCards organs/tissues related to Glossitis:

40
Tongue, Skin, Thyroid, Bone Marrow, Eye, Spinal Cord, Pancreas
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Publications for Glossitis

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Articles related to Glossitis:

(show top 50) (show all 771)
# Title Authors PMID Year
1
Hunter's Glossitis. 61
33162481 2021
2
Geographic tongue as a reaction-diffusion system. 61
33810753 2021
3
Pyoderma gangrenosum and cobalamin deficiency in systemic lupus erythematosus: a rare but non fortuitous association. 61
33653418 2021
4
Mesalazine-induced eosinophilic glossitis and hypereosinophilia in a patient with ulcerative colitis: a case report and review of literature. 61
33725368 2021
5
Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment. 61
33350542 2021
6
Are Oral Mucosal Changes a Sign of COVID-19? A Cross-Sectional Study at a Field Hospital. 61
33652010 2021
7
Dermatological Manifestations in Inflammatory Bowel Diseases. 61
33477990 2021
8
Gross and Histopathology of Goats Feeding on Opuntia stricta in Laikipia County, Kenya. 61
33623658 2021
9
Atrophic glossitis in pernicious anemia patients can be treated to normal in two weeks by intramuscular injection of vitamin B12. 61
33505632 2020
10
Oral Lesions in Captive Nondomestic Felids With a Focus on Odontogenic Lesions. 61
33016248 2020
11
[Recurrent peripheral facial nerve palsy]. 61
33631910 2020
12
Uraemic Encephalopathy in a Persian Cat with Chronic Kidney Disease. 61
33222866 2020
13
Zenker's diverticulum: a rare clinical condition with unusual oral manifestation. 61
33130589 2020
14
Oral adverse effects: drug-induced tongue disorders. 61
33052611 2020
15
Amyloidoma of the Tongue: Case Report, Surgical Management, and Review of the Literature. 61
32442425 2020
16
An Intriguing Case of Ectopic Benign Migratory Glossitis Resembling Secondary Syphilis: A Case Report. 61
33442352 2020
17
[Related factors of atrophic glossitis in 124 consecutive cases]. 61
33089295 2020
18
Oral manifestations related to malaria: A systematic review. 61
32657518 2020
19
Investigation of oral atopic diseases: Correlation between geographic tongue and fungiform papillary glossitis. 61
32540362 2020
20
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with normocytosis. 61
31362840 2020
21
Smart link of chronic atrophic gastritis with atrophic glossitis, gastric parietal cell antibody positivity, vitamin B12 deficiency, and hyperhomocysteinemia. 61
32024596 2020
22
Fatal canine parvovirus-2 (CPV-2) infection in a rescued free-ranging Taiwanese pangolin (Manis pentadactyla pentadactyla). 61
31886933 2020
23
Is chronic atrophic gastritis the missing link between atrophic glossitis, gastric parietal cell antibody positivity and hematological deficiencies? 61
31992475 2020
24
Median rhomboid glossitis associated with candida infection in a woman treated with ixekizumab. 61
32301726 2020
25
Atrophic glossitis: Etiology, serum autoantibodies, anemia, hematinic deficiencies, hyperhomocysteinemia, and management. 61
31076315 2020
26
Pernicious anemia presenting as glossitis. 61
32312826 2020
27
Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with vitamin B12 deficiency. 61
31630933 2020
28
Oral lesions as first clinical manifestations of Crohn's disease in paediatric patients: a report on 8 cases. 61
32183532 2020
29
The association between vitamin deficiency and otolaryngologic diseases: A therapeutic target. 61
31733530 2020
30
Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with iron deficiency. 61
31607629 2020
31
Sensitive monitoring of riboflavin in commercial multivitamins using poly (chitosan)-based nanocomposite. 61
31769086 2020
32
Herpetic glossitis. 61
32031526 2020
33
Managing Welfare and Antimicrobial-Resistance Issues in Treating Foot-and-Mouth Disease Lesions: A New Therapeutic Approach. 61
33117659 2020
34
[Oral health as a factor of primary prevention of postinfectious complications]. 61
33267538 2020
35
Prevalence of and related risk factors in oral mucosa diseases among residents in the Baoshan District of Shanghai, China. 61
32140308 2020
36
Anemia, hematinic deficiencies, and gastric parietal cell antibody positivity in atrophic glossitis patients with or without hyperhomocysteinemia. 61
31444017 2020
37
Chapter 6: Vitamins and Oral Health. 61
31940621 2020
38
Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs. 61
32038098 2020
39
Does serum gastric parietal cell antibody titer have influence on anemia and vitamin B12 deficiency in atrophic glossitis patients? 61
31277918 2020
40
[Modern perspectives of oral squamous cell carcinoma]. 61
32593268 2020
41
[Oral diagnosis of vitamin B12 deficiency due to long-term metformin treatment: a case report]. 61
33598094 2020
42
Ovine Abortion by Neospora caninum: First Case Reported in Argentina. 61
31485838 2019
43
Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with macrocytosis. 61
31324439 2019
44
Thirteen maxillary full dentures over 10 years: A case of peripheral painful traumatic trigeminal neuropathy. 61
31447327 2019
45
Atrophic Glossitis. 61
31618542 2019
46
Diarrhea: a missed D in the 4D glucagonoma syndrome. 61
31807436 2019
47
Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in atrophic glossitis patients with or without microcytosis. 61
31242967 2019
48
Ulcerative, granulomatous glossitis and enteritis caused by Rhodococcus equi in a heifer. 61
31347467 2019
49
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 61
31377720 2019
50
Identification of hypocrealean reptile pathogenic isolates with MALDI-TOF MS. 61
30445443 2019
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Variations for Glossitis

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Expression for Glossitis

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Search GEO for disease gene expression data for Glossitis.
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Pathways for Glossitis

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Pathways related to Glossitis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Keratinization 65
Show member pathways
 12.33 KRT6B KRT6A KRT17 KRT16
2
Folate Metabolism 1
Show member pathways
 12.14 TNF TCN2 IL6 IL1B
3
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.91 TNF SLC6A4 IL6 IL1B
4
Interleukin-4 and 13 signaling 65
11.86 TNF IL6 IL1B
5
TNF signaling pathway 36
11.85 TNF IL6 IL1B
6
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.83 KRT6A KRT17 KRT16
7
Amoebiasis 36
11.8 TNF IL6 IL1B
8
AGE-RAGE signaling pathway in diabetic complications 36
11.78 TNF IL6 IL1B
9
Hematopoietic cell lineage 36
11.77 TNF IL6 IL1B
10
Rheumatoid arthritis 36
11.73 TNF IL6 IL1B
11
Th1 Differentiation Pathway 64
Show member pathways
 11.62 TNF IL6 IL1B
12
Pertussis 36
11.61 TNF IL6 IL1B
13
Dendritic Cells Developmental Lineage Pathway 64
11.59 TNF IL6 IL1B
14
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.51 TNF IL6 IL1B
15
Lung fibrosis 1
11.5 TNF IL6 IL1B
16
Legionellosis 36
11.43 TNF IL6 IL1B
17
Malaria 36
11.35 TNF IL6 IL1B
18
Interleukin-10 signaling 65
11.32 TNF IL6 IL1B
19
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.26 TNF IL6 IL1B
20
Monoamine Transport 1
Show member pathways
 11.18 TNF SLC6A4 IL1B
21
African trypanosomiasis 36
11.07 TNF IL6 IL1B
22
IL-10 Pathway 63
10.98 TNF IL6 IL1B
23
Development and heterogeneity of the ILC family 1
10.84 TNF IL6 IL1B
24
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.67 IL6 IL1B
25
Antifolate resistance 36
10.62 TNF IL6 IL1B
26
Cytokines and Inflammatory Response 1
10.26 TNF IL6 IL1B
Sources

GO Terms for Glossitis

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Cellular components related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TTR TNF TCN2 IL6 IL36RN IL1B
2 intermediate filament GO:0005882 8.92 KRT6B KRT6A KRT17 KRT16

Biological processes related to Glossitis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.9 TNF IL6 IL36RN IL1B
2 inflammatory response GO:0006954 9.89 TNF KRT16 IL6 IL36RN IL1B
3 keratinization GO:0031424 9.83 KRT6B KRT6A KRT17 KRT16
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 TNF IL6 IL1B
5 defense response to Gram-positive bacterium GO:0050830 9.79 TNF KRT6A IL6
6 cellular response to lipopolysaccharide GO:0071222 9.78 TNF IL6 IL36RN IL1B
7 positive regulation of interleukin-6 production GO:0032755 9.77 TNF IL6 IL1B
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.76 TNF IL6 GCG
9 positive regulation of interleukin-8 production GO:0032757 9.71 TNF IL6 IL1B
10 cornification GO:0070268 9.71 KRT6B KRT6A KRT17 KRT16
11 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 TNF IL6
12 sodium ion export across plasma membrane GO:0036376 9.62 ATP4A ATP12A
13 cellular potassium ion homeostasis GO:0030007 9.62 ATP4A ATP12A
14 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.61 ATP4A ATP12A
15 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
16 negative regulation of lipid storage GO:0010888 9.57 TNF IL6
17 cobalamin transport GO:0015889 9.56 TCN2 LMBRD1
18 positive regulation of hair follicle development GO:0051798 9.55 TNF KRT17
19 negative regulation of neurogenesis GO:0050768 9.54 TNF IL6 IL1B
20 positive regulation of fever generation GO:0031622 9.51 TNF IL1B
21 morphogenesis of an epithelium GO:0002009 9.5 KRT6A KRT17 KRT16
22 sequestering of triglyceride GO:0030730 9.46 TNF IL1B
23 regulation of insulin secretion GO:0050796 9.46 TNF IL6 IL1B GCG
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B
25 positive regulation of glial cell proliferation GO:0060252 9.43 TNF IL6 IL1B
26 positive regulation of neuroinflammatory response GO:0150078 9.13 TNF IL6 IL1B
27 vascular endothelial growth factor production GO:0010573 8.8 TNF IL6 IL1B

Molecular functions related to Glossitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.54 KRT6B KRT6A KRT16
2 cytokine activity GO:0005125 9.46 TNF IL6 IL36RN IL1B
3 interleukin-1 receptor binding GO:0005149 9.4 IL36RN IL1B
4 cobalamin binding GO:0031419 9.32 TCN2 LMBRD1
5 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
6 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
7 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
Sources

Sources for Glossitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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