MCID: GLS004
MIFTS: 45

Glossopharyngeal Neuralgia

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Glossopharyngeal Neuralgia

MalaCards integrated aliases for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 11 19 52 58 75 14 71
Glossopharyngeal Nerve Diseases 43 71

Characteristics:


Prevelance:

1-9/1000000 (United States) 58

Age Of Onset:

Adolescent,Adult,Elderly 58

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Glossopharyngeal Neuralgia

NINDS: 52 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

MalaCards based summary: Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and trigeminal neuralgia. An important gene associated with Glossopharyngeal Neuralgia is KANTR (KANTR Integral Membrane Protein). The drugs Immunoglobulins and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include tongue, cortex and medulla oblongata, and related phenotypes are depression and anxiety

Orphanet: 58 A rare cranial neuralgia characterized by paroxysmal, usually unilateral stabbing pain within the sensory distributions of the auricular and pharyngeal branches of the glossopharyngeal and sometimes the vagus nerve (i. e. the posterior part of the tongue, the tonsillar fossa, oropharynx, larynx, angle of the mandible, and/or ear). The attacks last seconds to minutes with intervals between the paroxysms ranging from a few minutes to a few hours, and appear in clusters lasting weeks to months, again with irregular intervals in between. Pain attacks are usually triggered by a specific stimulus but may also occur spontaneously. The condition can sometimes be associated with bradycardia, syncope, seizures, and even asystole, and is then termed vagoglossopharyngeal neuralgia.

GARD: 19 Glossopharyngeal neuralgia is a disorder that is associated with repeated episodes of severe pain in the tongue, throat, ear, and tonsils. These areas are all connected to the ninth cranial nerve, also called the glossopharyngeal nerve. Episodes of pain may last from a few seconds to a few minutes and usually occur on one side of the face. The pain may be triggered by swallowing, speaking, laughing, chewing, or coughing. Glossopharyngeal neuralgia is thought to be caused by irritation of the glossopharyngeal nerve, but the exact cause of the irritation is sometimes unknown. Laboratory and imaging tests can be used to diagnose the disorder and rule out serious underlying problems.

Wikipedia: 75 Neuralgia (Greek neuron, "nerve" + algos, "pain") is pain in the distribution of one or more nerves, as... more...

Related Diseases for Glossopharyngeal Neuralgia

Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal nerve disease 31.6 TAC1 MPV17L2 KANTR CALCA
2 trigeminal neuralgia 29.9 TRPV1 TAC1 SCN9A P2RX3 KANTR CALCA
3 paine syndrome 29.7 TRPV1 TAC1 SCN9A P2RX3 CALCA
4 myofascial pain syndrome 29.2 TRPV1 TAC1 P2RX3 CALCA
5 migraine with or without aura 1 28.8 TRPV1 TAC1 SCN9A P2RX3 CALCA
6 combined hyperactive dysfunction syndrome of the cranial nerves 11.3
7 geniculate ganglionitis 11.2
8 syncope 10.9
9 pica disease 10.6
10 hemifacial spasm 10.6
11 bell's palsy 10.4
12 facial paralysis 10.4
13 cardiac arrest 10.4
14 cold-induced sweating syndrome 10.3
15 visual epilepsy 10.3
16 eagle syndrome 10.3
17 neurilemmoma 10.2
18 progressive familial heart block, type ia 10.1
19 arachnoid cysts, intracranial 10.1
20 progressive familial heart block, type ib 10.1
21 progressive familial heart block 10.1
22 hydrocephalus 10.1
23 arteriovenous malformation 10.1
24 acoustic neuroma 10.1
25 brain cancer 10.1
26 right bundle branch block 10.1
27 squamous cell carcinoma 10.1
28 cranial nerve palsy 10.1
29 oropharynx cancer 10.1
30 cerebrospinal fluid leak 10.1
31 cranial neuralgia 10.1
32 rare tumor 10.1
33 femoral cancer 10.1 TAC1 P2RX3
34 blepharospasm 10.1 TAC1 KANTR
35 focal dystonia 10.1 TAC1 KANTR
36 chronic pain 10.1 SCN9A P2RX3
37 bruxism 10.1 TAC1 KANTR
38 carbamazepine allergy 10.0 TAC1 CALCA
39 taylor's syndrome 10.0 TAC1 CALCA
40 lateral medullary syndrome 10.0 TAC1 CALCA
41 taeniasis 10.0 TAC1 CES1
42 perianal hematoma 10.0 TAC1 CALCA
43 interval angle-closure glaucoma 10.0 TAC1 CALCA
44 plantar fasciitis 10.0 TAC1 CALCA
45 frozen shoulder 10.0 TAC1 CALCA
46 epicondylitis 10.0 TAC1 CALCA
47 paralytic ileus 10.0 TAC1 CALCA
48 esophageal cancer 10.0
49 facial spasm 10.0
50 lipomatosis, multiple 10.0

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to Glossopharyngeal Neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

Human phenotypes related to Glossopharyngeal Neuralgia:

58 30 (show all 30)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depression 58 30 Frequent (33%) Frequent (79-30%)
HP:0000716
2 anxiety 58 30 Frequent (33%) Frequent (79-30%)
HP:0000739
3 tongue pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0030811
4 mandibular pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0200025
5 jaw claudication 58 30 Frequent (33%) Frequent (79-30%)
HP:0030164
6 ear pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0030766
7 cranial nerve compression 58 30 Frequent (33%) Frequent (79-30%)
HP:0001293
8 abnormal glossopharyngeal nerve morphology 58 30 Frequent (33%) Frequent (79-30%)
HP:3000047
9 episodic pain 58 30 Frequent (33%) Frequent (79-30%)
HP:0032148
10 seizure 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001250
11 autoimmunity 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002960
12 vocal cord paralysis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001605
13 hoarse voice 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001609
14 weight loss 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001824
15 headache 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002315
16 abnormal palate morphology 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000174
17 feeding difficulties 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0011968
18 syncope 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001279
19 abnormality of the cervical spine 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0003319
20 oral-pharyngeal dysphagia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0200136
21 dysesthesia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012534
22 malnutrition 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0004395
23 bradycardia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001662
24 odynophagia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0032043
25 chiari type i malformation 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0007099
26 schwannoma 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100008
27 vascular dilatation 30 Occasional (7.5%) HP:0002617
28 neoplasm 58 Occasional (29-5%)
29 dilatation 58 Occasional (29-5%)
30 hyperalgesia 58 Occasional (29-5%)

GenomeRNAi Phenotypes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 CALCA CES1 P2RX3

MGI Mouse Phenotypes related to Glossopharyngeal Neuralgia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 CALCA LONP1 MPV17L2 P2RX3 SCN9A SLC20A2
2 behavior/neurological MP:0005386 9.56 CALCA CES1 KANTR P2RX3 SCN9A SLC20A2
3 integument MP:0010771 9.23 CALCA CES1 MPV17L2 P2RX3 SCN9A SLC20A2

Drugs & Therapeutics for Glossopharyngeal Neuralgia

Drugs for Glossopharyngeal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4
2 Antibodies, Blocking Phase 4
3 Antibodies Phase 4
4
Iron Approved 7439-89-6 29936
5 Iron Supplement
6 Pharmaceutical Solutions
7 Analgesics
8 Analgesics, Opioid
9 Narcotics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia Active, not recruiting NCT04158752 Phase 4 Galcanezumab
2 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
3 Comparison of the Perception of Metallic Taste According to Lingual Locations in Healthy Volunteers Completed NCT05227157
4 MRI Observation After Ganglionic Local Opioid Analgesia at the Ganglion Cervicale Superius Recruiting NCT05257655

Search NIH Clinical Center for Glossopharyngeal Neuralgia

Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

Anatomical Context for Glossopharyngeal Neuralgia

Organs/tissues related to Glossopharyngeal Neuralgia:

MalaCards : Tongue, Cortex, Medulla Oblongata, Trigeminal Ganglion, Heart, Thyroid

Publications for Glossopharyngeal Neuralgia

Articles related to Glossopharyngeal Neuralgia:

(show top 50) (show all 606)
# Title Authors PMID Year
1
Endoscopic microvascular decompression without the use of rigid head fixation. 62
36371300 2022
2
Refractory glossopharyngeal neuralgia successfully treated with onabotulinumtoxinA: A case report. 62
36373801 2022
3
[Glossopharyngeal neuralgia associated with cardiac syncope in an octogenary patient]. 62
36280547 2022
4
Chiari type I malformation discovered through a glossopharyngeal neuralgia. 62
35256327 2022
5
Glossopharyngeal Neuralgia, An Usually Overlooked Diagnosis: A Prospective Single Center Observation Study. 62
36452818 2022
6
Neurovascular compression syndrome:Trigeminal neuralgia, hemifacial spasm, vestibular paroxysmia, glossopharyngeal neuralgia, four case reports and review of literature. 62
35932589 2022
7
Avellis syndrome with ipsilateral prosopalgia, glossopharyngeal neuralgia, and central post-stroke pain: A case report and literature review. 62
36181064 2022
8
Intravenous Fosphenytoin Therapy as an Acute Rescue Treatment for Glossopharyngeal Neuralgia Crisis in Patients Awaiting Neurosurgical Procedures: A Case Series. 62
36093916 2022
9
Data fusion and 3D visualization for optimized representation of neurovascular relationships in the posterior fossa. 62
35015156 2022
10
Imaging of Cranial Neuralgias. 62
35871786 2022
11
Curious case of neck pain caused by glossopharyngeal neuralgia. 62
35831098 2022
12
Glossopharyngeal Neuralgia Secondary to COVID-19: A Case Report. 62
35971353 2022
13
Glossopharyngeal Neuralgia Associated With Bradycardia and syncope-a Case Report. 62
35755242 2022
14
Eagle's Syndrome: A Diagnostic Challenge and Surgical Dilemma. 62
35712413 2022
15
Utility of Neuroimaging in the Management of Chronic and Acute Headache. 62
35490044 2022
16
Gamma Knife radiosurgery and refractory glossopharyngeal neuralgia: a single-center series with long-term follow-up. 62
33977410 2022
17
Glossopharyngeal Neuralgia: Epidemiology, Risk factors, Pathophysiology, Differential diagnosis, and Treatment Options. 62
35774913 2022
18
Novel Use of Glossopharyngeal SSEP in Microvascular Decompression for Glossopharyngeal Neuralgia. 62
35263935 2022
19
Linear accelerator-based stereotactic radiosurgery for glossopharyngeal neuralgia is safe and effective - Report of two cases. 62
36275126 2022
20
The Underlying Pathogenesis of Neurovascular Compression Syndromes: A Systematic Review. 62
35860499 2022
21
Gamma Knife Radiosurgery for Concurrent Trigeminal Neuralgia and Glossopharyngeal Neuralgia. 62
35106251 2021
22
Prognostic factors for long-term outcomes of microvascular decompression in the treatment of glossopharyngeal neuralgia: a retrospective analysis of 97 patients. 62
34920419 2021
23
Imaging of Trigeminal Neuralgia and Other Facial Pain. 62
34689929 2021
24
Posterior condylar canal dural arteriovenous fistula as a rare cause of glossopharyngeal neuralgia: A case report. 62
34309850 2021
25
Treatment of trigeminal and glossopharyngeal neuralgia in an adolescent: a case report. 62
34365546 2021
26
A case of syncopal convulsions triggered by glossopharyngeal neuralgia. 62
34318920 2021
27
Microvascular Decompression for Glossopharyngeal Neuralgia in the Semi-Sitting Position: A Report of Two Cases. 62
34261821 2021
28
Management of recurrent glossopharyngeal neuralgia after a failed microvascular decompression. 62
33733714 2021
29
Selection of treatment strategies for recurrent glossopharyngeal neuralgia after MVD. 62
33569713 2021
30
The Clinical Characteristics and Surgical Treatment of Glossopharyngeal Neuralgia With Pain Radiating to the Innervated Area of the Trigeminal Nerve. 62
33571461 2021
31
Endoscopic microvascular decompression for glossopharyngeal neuralgia. 62
33629123 2021
32
The Clinical Characteristics and Surgical Treatment of Glossopharyngeal Neuralgia With Pain Radiating to the Innervated Area of the Trigeminal Nerve. 62
33387474 2021
33
Teaching NeuroImages: Glossopharyngeal Nerve Focal Pressure Atrophy in Glossopharyngeal Neuralgia. 62
33277410 2021
34
Salvage gamma knife surgery for recurrent glossopharyngeal neuralgia following microvascular decompression: a retrospective case series. 62
33219443 2021
35
Life-threatening complications after microvascular decompression procedure: Lessons from a consecutive series of 596 patients. 62
33775349 2021
36
Risk factors for wound-related complications after microvascular decompression. 62
32306156 2021
37
Microvascular decompression using a fully transcranial neuroendoscopic approach. 62
33491507 2021
38
Repeated loss of consciousness as the first symptom of recurrence of head and neck malignancy: a case report. 62
33644641 2021
39
Thermographic follow-up of postherpetic neuralgia (PHN) subsequent to Ramsay Hunt syndrome with multicranial nerve (V, VII, VIII and IX) involvement: a case report. 62
33509130 2021
40
A Rare Complication of Tonsillectomy: Glossopharyngeal Neuralgia. 62
32694475 2021
41
Microvascular decompression for a unique case of glossopharyngeal neuralgia with provokable symptomatic bradycardia: 2-Dimensional operative video. 62
34877056 2021
42
Commentary: Neurosurgical Choice for Glossopharyngeal Neuralgia: A Benefit-Harm Assessment of Long-Term Quality of Life. 62
32735646 2020
43
Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia. 62
28330711 2020
44
Endoscopic Microvascular Decompression for Vagoglossopharyngeal Neuralgia. 62
33520548 2020
45
Neurosurgical Choice for Glossopharyngeal Neuralgia: A Benefit-Harm Assessment of Long-Term Quality of Life. 62
32735682 2020
46
How I do it: endoscopic microvascular decompression for glossopharyngeal neuralgia. 62
32556527 2020
47
Reoperation after failed microvascular decompression for glossopharyngeal neuralgia. 62
32383016 2020
48
Concurrent Glossopharyngeal Neuralgia and Hemi-Laryngopharyngeal Spasm (HeLPS): A Case Report and a Review of the Literature. 62
31832655 2020
49
Study of the Anatomical Features of the Offending Arteries Involved in Glossopharyngeal Neuralgia. 62
31960063 2020
50
Augmented Visualization Surgical Microscope Assisted Microvascular Decompression for Hemifacial Spasm. 62
32472917 2020

Variations for Glossopharyngeal Neuralgia

Expression for Glossopharyngeal Neuralgia

Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for Glossopharyngeal Neuralgia

GO Terms for Glossopharyngeal Neuralgia

Cellular components related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.46 TRPV1 SCN9A P2RX3 CALCA
2 axon GO:0030424 9.43 TAC1 SCN9A P2RX3 CALCA
3 neuronal cell body GO:0043025 9.23 TRPV1 TAC1 P2RX3 CALCA

Biological processes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.04 TRPV1 TAC1 SCN9A CALCA
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.99 TRPV1 TAC1 CALCA
3 monoatomic ion transport GO:0006811 9.88 TRPV1 SLC20A2 SCN9A P2RX3
4 neuronal action potential GO:0019228 9.83 SCN9A P2RX3
5 sensory perception of pain GO:0019233 9.8 SCN9A TAC1 TRPV1
6 cellular response to nerve growth factor stimulus GO:1990090 9.8 TRPV1 TAC1 CALCA
7 cellular response to ATP GO:0071318 9.76 TRPV1 P2RX3
8 monoatomic ion transmembrane transport GO:0034220 9.71 TRPV1 SCN9A P2RX3
9 behavioral response to formalin induced pain GO:0061368 9.67 SCN9A P2RX3
10 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.65 TRPV1 SCN9A CALCA
11 urinary bladder smooth muscle contraction GO:0014832 9.61 TRPV1 P2RX3
12 response to pain GO:0048265 9.55 TRPV1 TAC1 CALCA
13 behavioral response to pain GO:0048266 9.26 TRPV1 SCN9A P2RX3
14 response to heat GO:0009408 9.17 TRPV1 SCN9A P2RX3 CALCA

Molecular functions related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monoatomic ion channel activity GO:0005216 8.92 TRPV1 SCN9A P2RX3

Sources for Glossopharyngeal Neuralgia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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