MCID: GLS004
MIFTS: 34

Glossopharyngeal Neuralgia

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Glossopharyngeal Neuralgia

MalaCards integrated aliases for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 12 76 53 54 59 15 73
Glossopharyngeal Nerve Diseases 44 73

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:14423
ICD10 33 G52.1
ICD9CM 35 352.1
MeSH 44 D020435
SNOMED-CT 68 43763009
Orphanet 59 ORPHA221098
UMLS via Orphanet 74 C0154731
ICD10 via Orphanet 34 G52.1

Summaries for Glossopharyngeal Neuralgia

NIH Rare Diseases : 53 Glossopharyngeal neuralgia is a disorder that is associated with repeated episodes of severe pain in the tongue, throat, ear, and tonsils. These areas are all connected to the ninth cranial nerve, also called the glossopharyngeal nerve. Episodes of pain may last from a few seconds to a few minutes and usually occur on one side of the face. The pain may be triggered by swallowing, speaking, laughing, chewing, or coughing. Glossopharyngeal neuralgia is thought to be caused by irritation of the glossopharyngeal nerve, but the exact cause of the irritation is sometimes unknown. Laboratory and imaging tests can be used to diagnose the disorder and rule out serious underlying problems. The goal of treatment is to control pain, and the most effective drugs are anti-seizure medications and anti-depressants. Surgery to sever or take pressure off of the glossopharyngeal nerve may be needed in severe cases.

MalaCards based summary : Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and geniculate ganglionitis. An important gene associated with Glossopharyngeal Neuralgia is POMC (Proopiomelanocortin). Affiliated tissues include tongue, tonsil and testes, and related phenotype is Reduced mammosphere formation.

NINDS : 54 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

Wikipedia : 76 Neuralgia (Greek neuron, \"nerve\" + algos, \"pain\") is pain in the distribution of a nerve or nerves,... more...

Related Diseases for Glossopharyngeal Neuralgia

Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal nerve disease 34.3 CRLF1 SON
2 geniculate ganglionitis 11.2
3 syncope 10.7
4 syndrome of inappropriate antidiuretic hormone 10.5 POMC VIM
5 trigeminal neuralgia 10.5
6 thyroid crisis 10.5 KANTR POMC
7 laryngeal tuberculosis 10.4 KANTR POMC
8 rh isoimmunization 10.4 NUMA1 POMC
9 hemifacial spasm 10.4
10 hyperhidrosis, gustatory 10.4 CANX KANTR
11 shwartzman phenomenon 10.4 KANTR POMC
12 neurodermatitis 10.3 KANTR POMC
13 visual agnosia 10.3 KANTR NUMA1
14 lateral medullary syndrome 10.3 CANX KANTR
15 cardiac arrest 10.2
16 type i 10.2
17 premenstrual tension 10.2 KANTR POMC
18 dystonia 1, torsion, autosomal dominant 10.1 KANTR VIM
19 choroiditis 10.1
20 arachnoiditis 10.1
21 hemidystonia 10.1 KANTR VIM
22 transient global amnesia 10.1 CRLF1 KANTR
23 multiple sclerosis 10.0
24 testicular leydig cell tumor 10.0 NR5A2 POMC
25 cold-induced sweating syndrome 10.0 CRLF1 KANTR
26 cardiac arrhythmia 9.9
27 facial spasm 9.9
28 spinal arachnoiditis 9.9
29 paine syndrome 9.9
30 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
31 arteriovenous malformation 9.9
32 sick sinus syndrome 9.9
33 squamous cell carcinoma 9.9
34 pharyngitis 9.9
35 cervicitis 9.9
36 myoepithelioma 9.9
37 cerebritis 9.9
38 laryngitis 9.9
39 conjunctivitis 9.9
40 thyroiditis 9.9
41 arachnoid cysts 9.9
42 cluster headache 9.9
43 headache 9.9
44 combined hyperactive dysfunction syndrome of the cranial nerves 9.9
45 glomangioma 9.6 KANTR VIM

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to Glossopharyngeal Neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

GenomeRNAi Phenotypes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 NR5A2 NUMA1 POMC VIM HNF4A

Drugs & Therapeutics for Glossopharyngeal Neuralgia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Suspended NCT02321566 Phase 1

Search NIH Clinical Center for Glossopharyngeal Neuralgia

Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

Anatomical Context for Glossopharyngeal Neuralgia

MalaCards organs/tissues related to Glossopharyngeal Neuralgia:

41
Tongue, Tonsil, Testes, Cortex, Heart, Thyroid, Trigeminal Ganglion

Publications for Glossopharyngeal Neuralgia

Articles related to Glossopharyngeal Neuralgia:

(show top 50) (show all 235)
# Title Authors Year
1
A Case of Vago-Glossopharyngeal Neuralgia Caused by Choroid Plexus. ( 29682078 )
2018
2
Continuous radiofrequency thermocoagulation under CT-guidance for glossopharyngeal neuralgia: Two case reports: Erratum. ( 29979451 )
2018
3
Microvascular decompression for glossopharyngeal neuralgia: a retrospective analysis of 228 cases. ( 29103137 )
2018
4
Pulsed Radiofrequency Ablation for the Treatment of Glossopharyngeal Neuralgia Secondary to Oropharyngeal Carcinoma. ( 29871374 )
2018
5
The tethered effect of the arachnoid in vago-glossopharyngeal neuralgia: a real associated alternative mechanism? ( 29075903 )
2018
6
Management Of Recurrent Glossopharyngeal Neuralgia Following Microvascular Decompression Surgery: A Case Report. ( 29960093 )
2018
7
Surgical treatment of bilateral glossopharyngeal neuralgia. ( 29888997 )
2018
8
Continuous radiofrequency thermocoagulation under CT-guidance for glossopharyngeal neuralgia: Two case reports. ( 29901619 )
2018
9
Gamma Knife radiosurgery for glossopharyngeal neuralgia: A study of 21 patients with long-term follow-up. ( 28952337 )
2017
10
Glossopharyngeal neuralgia treated by Gamma Knife radiosurgery: safety and efficacy through long-term follow-up. ( 28621622 )
2017
11
Magnetic Resonance (MR) Imaging Assessment for Glossopharyngeal Neuralgia: Value of Three-Dimensional T2-Reversed MR Imaging (3D-T2R) in Conjunction with Other Modes of 3D MR Imaging. ( 29657629 )
2017
12
Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia. ( 28330711 )
2017
13
A Rare Case of Glossopharyngeal Neuralgia due to Neurovascular Conflict. ( 29515426 )
2017
14
Treatments of glossopharyngeal neuralgia: towards standard procedures. ( 28527060 )
2017
15
Recurrent syncope due to glossopharyngeal neuralgia. ( 28491772 )
2017
16
Microvascular Decompression for a Patient with a Glossopharyngeal Neuralgia: A Technical Note. ( 28948114 )
2017
17
Microvascular Decompression for Glossopharyngeal Neuralgia: Clinical Analyses of 30 Cases. ( 29142635 )
2017
18
Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update. ( 28827979 )
2017
19
The emerging role of gamma knife radiosurgery in the management of glossopharyngeal neuralgia. ( 28748271 )
2017
20
Microvascular Decompression for Glossopharyngeal Neuralgia: Long-Term Follow-Up. ( 28263933 )
2017
21
Glossopharyngeal neuralgia associated with cardiac syncope. ( 27102416 )
2016
22
Microvascular decompression for glossopharyngeal neuralgia using intraoperative neurophysiological monitoring: Technical case report. ( 26862458 )
2016
23
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. ( 26892985 )
2016
24
Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: an international multicenter study. ( 27903192 )
2016
25
Microvascular decompression for glossopharyngeal neuralgia through a microasterional approach: A case series. ( 27213105 )
2016
26
Long-term outcomes of percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective observational study. ( 27902620 )
2016
27
A Perforating Artery Compressing the Nerve Rootlet and Causing Glossopharyngeal Neuralgia. ( 26103445 )
2015
28
Case report: Recurrent glossopharyngeal neuralgia after previous glossopharyngeal rhizotomy: Microvascular decompression with intra-operative neurophysiology. ( 25958960 )
2015
29
Vago-glossopharyngeal neuralgia: a literature review of neurosurgical experience. ( 25526720 )
2015
30
The incidence of high-frequency hearing loss after microvascular decompression for trigeminal neuralgia, glossopharyngeal neuralgia, or geniculate neuralgia. ( 25932612 )
2015
31
Glossopharyngeal nerve contrast enhancement in recent-onset glossopharyngeal neuralgia. ( 25802271 )
2015
32
Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia by Targeting the Medial Cisternal Segment of the Glossopharyngeal Nerve: Report of 3 Cases. ( 26183516 )
2015
33
Classification of neurovascular compression in glossopharyngeal neuralgia: Three-dimensional visualization of the glossopharyngeal nerve. ( 26759734 )
2015
34
Neurosurgical treatment of glossopharyngeal neuralgia: analysis of 103 cases. ( 26339847 )
2015
35
Treatment of Glossopharyngeal Neuralgia by Gamma Knife Radiosurgery. ( 26348903 )
2015
36
Glossopharyngeal neuralgia caused by a complex neurovascular conflict: Case report and review of the literature. ( 25709856 )
2015
37
Glossopharyngeal neuralgia associated with cardiac syncope: Two case reports and literature review. ( 25974354 )
2015
38
Conventional and 3-Dimensional Computerized Tomography in Eagle's Syndrome, Glossopharyngeal Neuralgia, and Asymptomatic Controls. ( 25917666 )
2015
39
The treatment of combined trigeminal and glossopharyngeal neuralgia by glycerol rhizolysis of the trigeminal ganglion. ( 25222621 )
2014
40
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. ( 24604137 )
2014
41
Intraoperative neurophysiological monitoring of microvascular decompression for glossopharyngeal neuralgia. ( 25083845 )
2014
42
Peripheral Facial Palsy and Glossopharyngeal Neuralgia Caused by Malignant Myoepithelioma. ( 26077185 )
2014
43
Endovascular Microcatheter Provocation Test for the Diagnosis of Glossopharyngeal Neuralgia. ( 24435838 )
2014
44
Glossopharyngeal neuralgia and radiosurgery. ( 25434956 )
2014
45
Trigeminal and glossopharyngeal neuralgia. ( 24703544 )
2014
46
Lipoma causing glossopharyngeal neuralgia: a case report and review of literature. ( 25328654 )
2014
47
Analgesic efficacy and safety of medical therapy alone vs combined medical therapy and extraoral glossopharyngeal nerve block in glossopharyngeal neuralgia. ( 23279193 )
2013
48
Glossopharyngeal neuralgia treated with an endoscopic assisted midline suboccipital subtonsillar approach: technical note. ( 23042141 )
2013
49
Use of electrophysiological monitoring in selective rhizotomy treating glossopharyngeal neuralgia. ( 24095216 )
2013
50
Treatment Of Glossopharyngeal Neuralgia With Peripheral Glycerol Injection:Our Experience In Twenty One Older Patients. ( 24102955 )
2013

Variations for Glossopharyngeal Neuralgia

Expression for Glossopharyngeal Neuralgia

Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for Glossopharyngeal Neuralgia

GO Terms for Glossopharyngeal Neuralgia

Biological processes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular receptor signaling pathway GO:0030522 8.96 HNF4A NR5A2
2 interleukin-27-mediated signaling pathway GO:0070106 8.62 CANX CRLF1

Molecular functions related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 8.62 HNF4A NR5A2

Sources for Glossopharyngeal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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