MCID: GLS004
MIFTS: 37

Glossopharyngeal Neuralgia

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Glossopharyngeal Neuralgia

MalaCards integrated aliases for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 12 73 20 53 58 15 70
Glossopharyngeal Nerve Diseases 44 70

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:14423
ICD9CM 34 352.1
MeSH 44 D020435
SNOMED-CT 67 43763009
ICD10 32 G52.1
ICD10 via Orphanet 33 G52.1
UMLS via Orphanet 71 C0154731
Orphanet 58 ORPHA221098
UMLS 70 C0154731 C0751941

Summaries for Glossopharyngeal Neuralgia

GARD : 20 Glossopharyngeal neuralgia is a disorder that is associated with repeated episodes of severe pain in the tongue, throat, ear, and tonsils. These areas are all connected to the ninth cranial nerve, also called the glossopharyngeal nerve. Episodes of pain may last from a few seconds to a few minutes and usually occur on one side of the face. The pain may be triggered by swallowing, speaking, laughing, chewing, or coughing. Glossopharyngeal neuralgia is thought to be caused by irritation of the glossopharyngeal nerve, but the exact cause of the irritation is sometimes unknown. Laboratory and imaging tests can be used to diagnose the disorder and rule out serious underlying problems. The goal of treatment is to control pain, and the most effective drugs are anti-seizure medications and anti-depressants. Surgery to sever or take pressure off of the glossopharyngeal nerve may be needed in severe cases.

MalaCards based summary : Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and arachnoiditis. An important gene associated with Glossopharyngeal Neuralgia is POMC (Proopiomelanocortin). The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include tongue, cortex and heart, and related phenotypes are seizures and depressivity

NINDS : 53 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

Wikipedia : 73 Neuralgia (Greek neuron, "nerve" + algos, "pain") is pain in the distribution of a nerve or nerves, as... more...

Related Diseases for Glossopharyngeal Neuralgia

Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal nerve disease 31.7 SLC20A2 LONP1 CANX
2 arachnoiditis 30.0 TAC1 POMC
3 migraine with or without aura 1 29.8 TAC1 SLC20A2 POMC
4 cranial nerve palsy 29.8 SLC52A1 POMC
5 geniculate ganglionitis 11.2
6 syncope 10.9
7 trigeminal neuralgia 10.9
8 pica disease 10.6
9 hemifacial spasm, familial 10.6
10 hemifacial spasm 10.6
11 dysphagia 10.6
12 cardiac arrest 10.4
13 facial paralysis 10.4
14 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
15 seizure disorder 10.3
16 squamous cell carcinoma 10.2
17 neurilemmoma 10.2
18 progressive familial heart block, type ia 10.1
19 multiple sclerosis 10.1
20 progressive familial heart block, type ib 10.1
21 hydrocephalus 10.1
22 arteriovenous malformation 10.1
23 right bundle branch block 10.1
24 oropharynx cancer 10.1
25 cerebrospinal fluid leak 10.1
26 cranial neuralgia 10.1
27 rare tumor 10.1
28 myofascial pain syndrome 10.1 TAC1 POMC
29 neurodermatitis 10.0 TAC1 POMC
30 somatization disorder 10.0 TAC1 POMC
31 motion sickness 10.0 TAC1 POMC
32 complex regional pain syndrome 10.0 TAC1 POMC
33 cardiac arrhythmia 10.0
34 esophageal cancer 10.0
35 facial spasm 10.0
36 lipomatosis, multiple 10.0
37 spinal arachnoiditis 10.0
38 syringomyelia, noncommunicating isolated 10.0
39 temporal arteritis 10.0
40 triiodothyronine receptor auxiliary protein 10.0
41 papilloma of choroid plexus 10.0
42 paine syndrome 10.0
43 branchiootic syndrome 1 10.0
44 major depressive disorder 10.0
45 cyanosis, transient neonatal 10.0
46 atrioventricular block 10.0
47 tongue carcinoma 10.0
48 pleomorphic lipoma 10.0
49 tonsillitis 10.0
50 pulpitis 10.0

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to Glossopharyngeal Neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

Human phenotypes related to Glossopharyngeal Neuralgia:

58 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 58 Occasional (29-5%)
2 depressivity 58 Frequent (79-30%)
3 anxiety 58 Frequent (79-30%)
4 autoimmunity 58 Occasional (29-5%)
5 vocal cord paralysis 58 Occasional (29-5%)
6 neoplasm 58 Occasional (29-5%)
7 hoarse voice 58 Occasional (29-5%)
8 weight loss 58 Occasional (29-5%)
9 headache 58 Occasional (29-5%)
10 abnormal palate morphology 58 Occasional (29-5%)
11 dilatation 58 Occasional (29-5%)
12 feeding difficulties 58 Occasional (29-5%)
13 syncope 58 Occasional (29-5%)
14 abnormality of the cervical spine 58 Occasional (29-5%)
15 tongue pain 58 Frequent (79-30%)
16 oral-pharyngeal dysphagia 58 Occasional (29-5%)
17 dysesthesia 58 Occasional (29-5%)
18 malnutrition 58 Occasional (29-5%)
19 mandibular pain 58 Frequent (79-30%)
20 arnold-chiari type i malformation 58 Occasional (29-5%)
21 schwannoma 58 Occasional (29-5%)
22 jaw claudication 58 Frequent (79-30%)
23 bradycardia 58 Occasional (29-5%)
24 ear pain 58 Frequent (79-30%)
25 cranial nerve compression 58 Frequent (79-30%)
26 abnormal glossopharyngeal nerve morphology 58 Frequent (79-30%)
27 hyperalgesia 58 Occasional (29-5%)
28 episodic pain 58 Frequent (79-30%)
29 odynophagia 58 Occasional (29-5%)

Drugs & Therapeutics for Glossopharyngeal Neuralgia

Drugs for Glossopharyngeal Neuralgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4
2 Antibodies Phase 4
3 Antibodies, Blocking Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia Recruiting NCT04158752 Phase 4 Galcanezumab
2 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1

Search NIH Clinical Center for Glossopharyngeal Neuralgia

Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

Anatomical Context for Glossopharyngeal Neuralgia

MalaCards organs/tissues related to Glossopharyngeal Neuralgia:

40
Tongue, Cortex, Heart, Medulla Oblongata, Trigeminal Ganglion, Thyroid

Publications for Glossopharyngeal Neuralgia

Articles related to Glossopharyngeal Neuralgia:

(show top 50) (show all 578)
# Title Authors PMID Year
1
Life-threatening complications after microvascular decompression procedure: Lessons from a consecutive series of 596 patients. 61
33775349 2021
2
The Clinical Characteristics and Surgical Treatment of Glossopharyngeal Neuralgia With Pain Radiating to the Innervated Area of the Trigeminal Nerve. 61
33387474 2021
3
Salvage gamma knife surgery for recurrent glossopharyngeal neuralgia following microvascular decompression: a retrospective case series. 61
33219443 2021
4
Endoscopic microvascular decompression for glossopharyngeal neuralgia. 61
33629123 2021
5
Management of recurrent glossopharyngeal neuralgia after a failed microvascular decompression. 61
33733714 2021
6
The Clinical Characteristics and Surgical Treatment of Glossopharyngeal Neuralgia With Pain Radiating to the Innervated Area of the Trigeminal Nerve. 61
33571461 2021
7
Selection of treatment strategies for recurrent glossopharyngeal neuralgia after MVD. 61
33569713 2021
8
A Rare Complication of Tonsillectomy: Glossopharyngeal Neuralgia. 61
32694475 2021
9
Thermographic follow-up of postherpetic neuralgia (PHN) subsequent to Ramsay Hunt syndrome with multicranial nerve (V, VII, VIII and IX) involvement: a case report. 61
33509130 2021
10
Repeated loss of consciousness as the first symptom of recurrence of head and neck malignancy: a case report. 61
33644641 2021
11
Microvascular decompression using a fully transcranial neuroendoscopic approach. 61
33491507 2021
12
Teaching Neuroimages: Glossopharyngeal nerve focal pressure atrophy in glossopharyngeal neuralgia. 61
33277410 2020
13
Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia. 61
28330711 2020
14
Neurosurgical Choice for Glossopharyngeal Neuralgia: A Benefit-Harm Assessment of Long-Term Quality of Life. 61
32735682 2020
15
Commentary: Neurosurgical Choice for Glossopharyngeal Neuralgia: A Benefit-Harm Assessment of Long-Term Quality of Life. 61
32735646 2020
16
Endoscopic Microvascular Decompression for Vagoglossopharyngeal Neuralgia. 61
33520548 2020
17
Reoperation after failed microvascular decompression for glossopharyngeal neuralgia. 61
32383016 2020
18
How I do it: endoscopic microvascular decompression for glossopharyngeal neuralgia. 61
32556527 2020
19
Concurrent Glossopharyngeal Neuralgia and Hemi-Laryngopharyngeal Spasm (HeLPS): A Case Report and a Review of the Literature. 61
31832655 2020
20
Study of the Anatomical Features of the Offending Arteries Involved in Glossopharyngeal Neuralgia. 61
31960063 2020
21
Augmented Visualization Surgical Microscope Assisted Microvascular Decompression for Hemifacial Spasm. 61
32472917 2020
22
Glossopharyngeal neuralgia as initial symptom in combined hyperactive dysfunction syndrome: case report. 61
32915076 2020
23
Microvascular Decompression Surgery for Elderly Patients: A Study Based on Proposals from the Joint Committee of the Japan Gerontological Society and the Japan Geriatrics Society. 61
32801275 2020
24
Low origin of the persistent hypoglossal artery associated with high carotid bifurcation: a case report. 61
32172358 2020
25
Eagle's Syndrome Managed Successfully by Pulsed Radiofrequency Treatment. 61
33101818 2020
26
Glossopharyngeal Neuralgia/Neuropathy with Hemodynamic Instability and Associated Syncope Treated with Stereotactic Radiosurgery. 61
32344136 2020
27
Ganglioneuroma of Glossopharyngeal Nerve in a Patient with Glossopharyngeal Neuralgia: A Case Report. 61
32695559 2020
28
Carotid Artery Enlargement Causing Glossopharyngeal Neuralgia Successfully Treated with Stenting. 61
31444498 2020
29
CRANIAL NERVE HYPERFUNCTION SYNDROMES. MODERN APPROACHES TO DIAGNOSIS AND TREATMENT (REVIEW). 61
32841192 2020
30
A Unique Case of Microvascular Triple Decompression for Combined Simultaneous Trigeminal Neuralgia, Hemifacial Spasm, and Glossopharyngeal Neuralgia Because of the Dolichoectatic Vertebrobasilar System. 61
31334555 2020
31
Case of vago-glossopharyngeal neuralgia secondary to metastatic oropharyngeal cancer. 61
32595127 2020
32
Clinical long-term observation of the keyhole microvascular decompression with local anesthesia on diagnosis and treatment of vestibular paroxysmia. 61
32068485 2020
33
In the Differential for Glossopharyngeal Neuralgia, do not Forget the Esophagus. 61
32643696 2020
34
Letter to the Editor. Radiosurgery is a valuable alternative to microvascular decompression for glossopharyngeal neuralgia. 61
32357332 2020
35
Radiofrequency ablation and phenol neurolysis in a case of glossopharyngeal neuralgia due to a rare aetiology. 61
32724257 2020
36
Risk factors for wound-related complications after microvascular decompression. 61
32306156 2020
37
Neurotologic Complications Following Microvascular Decompression: A Retrospective Study. 61
32021748 2020
38
The outcomes of a second and third Gamma Knife radiosurgery for recurrent essential glossopharyngeal neuralgia. 61
31848788 2020
39
The Long-Term Outcome of CT-Guided Pulsed Radiofrequency in the Treatment of Idiopathic Glossopharyngeal Neuralgia: A Retrospective Multi-Center Case Series. 61
32904498 2020
40
Successful frameless radiosurgery for glossopharyngeal neuralgia - Case report. 61
32802583 2020
41
Repeat Gamma Knife Radiosurgery for Recurrent Glossopharyngeal Neuralgia: A Systematic Review and Our Initial Experience. 61
32810861 2020
42
Microvascular Decompression Alone without Rhizotomy Is an Effective Way of Treating Glossopharyngeal Neuralgia: Clinical Analysis of 46 Cases. 61
32101860 2020
43
Ameliorating Effect of Microvascular Decompression on Patients with Coexistence of Hemifacial Spasm and Glossopharyngeal Neuralgia: A Retrospective Study. 61
31442648 2020
44
Radiosurgery for Epidermoid Tumors: Dramatic Pain Relief from Trigeminal Neuralgia. 61
31893192 2019
45
Human papillomavirus-positive oropharyngeal squamous cell carcinoma manifesting as glossopharyngeal neuralgia. 61
31761020 2019
46
Rare Case of Concurrent Glossopharyngeal and Trigeminal Neuralgia, in Which Glossopharyngeal Neuralgia was Possibly Induced by Postoperative Changes Following Microvascular Decompression for Trigeminal Neuralgia. 61
31295589 2019
47
Combined Hyperactive Dysfunction Syndrome of the Cranial Nerves: Analysis of 37 Cases and Literature Review. 61
31158546 2019
48
Glossopharyngeal Neuralgia: A Multidimensional Challenge. 61
31581374 2019
49
Adverse Events After Microvascular Decompression: A National Surgical Quality Improvement Program Analysis. 61
31082546 2019
50
Eslicarbazepine acetate for neuropathic pain, headache, and cranial neuralgia: Evidence and experience. 61
28215909 2019

Variations for Glossopharyngeal Neuralgia

Expression for Glossopharyngeal Neuralgia

Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for Glossopharyngeal Neuralgia

GO Terms for Glossopharyngeal Neuralgia

Biological processes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.26 TAC1 POMC
2 viral entry into host cell GO:0046718 9.16 SLC52A1 SLC20A2
3 regulation of blood pressure GO:0008217 8.96 TAC1 POMC
4 response to hormone GO:0009725 8.62 TAC1 LONP1

Molecular functions related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 SLC52A1 SLC20A2

Sources for Glossopharyngeal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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