MCID: GLS004
MIFTS: 34

Glossopharyngeal Neuralgia

Categories: Ear diseases, Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Glossopharyngeal Neuralgia

MalaCards integrated aliases for Glossopharyngeal Neuralgia:

Name: Glossopharyngeal Neuralgia 12 77 54 55 60 15 74
Glossopharyngeal Nerve Diseases 45 74

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:14423
ICD9CM 36 352.1
MeSH 45 D020435
SNOMED-CT 69 43763009
ICD10 34 G52.1
ICD10 via Orphanet 35 G52.1
UMLS via Orphanet 75 C0154731
Orphanet 60 ORPHA221098

Summaries for Glossopharyngeal Neuralgia

NIH Rare Diseases : 54 Glossopharyngeal neuralgia is a disorder that is associated with repeated episodes of severe pain in the tongue, throat, ear, and tonsils. These areas are all connected to the ninth cranial nerve, also called the glossopharyngeal nerve. Episodes of pain may last from a few seconds to a few minutes and usually occur on one side of the face. The pain may be triggered by swallowing, speaking, laughing, chewing, or coughing. Glossopharyngeal neuralgia is thought to be caused by irritation of the glossopharyngeal nerve, but the exact cause of the irritation is sometimes unknown. Laboratory and imaging tests can be used to diagnose the disorder and rule out serious underlying problems. The goal of treatment is to control pain, and the most effective drugs are anti-seizure medications and anti-depressants. Surgery to sever or take pressure off of the glossopharyngeal nerve may be needed in severe cases.

MalaCards based summary : Glossopharyngeal Neuralgia, also known as glossopharyngeal nerve diseases, is related to glossopharyngeal nerve disease and geniculate ganglionitis. An important gene associated with Glossopharyngeal Neuralgia is POMC (Proopiomelanocortin). Affiliated tissues include tongue, tonsil and testes.

NINDS : 55 Glossopharyngeal neuralgia (GN) is a rare pain syndrome that affects the glossopharyngeal nerve (the ninth cranial nerve that lies deep within the neck)  and causes sharp, stabbing pulses of pain in the back of the throat and tongue, the tonsils, and the middle ear.  The excruciating pain of GN can last for a few seconds to a few minutes, and may return multiple times in a day or once every few weeks.  Many individuals with GN relate the attacks of pain to specific trigger factors such as swallowing, drinking cold liquids, sneezing, coughing, talking, clearing the throat, and touching the gums or inside the mouth.  GN can be caused by compression of the glossopharyngeal nerve, but in some cases, no cause is evident.  Like trigeminal neuralgia, it is associated with multiple sclerosis.  GN primarily affects the elderly.

Wikipedia : 77 Neuralgia (Greek neuron, "nerve" + algos, "pain") is pain in the distribution of a nerve or nerves, as... more...

Related Diseases for Glossopharyngeal Neuralgia

Diseases related to Glossopharyngeal Neuralgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 glossopharyngeal nerve disease 34.1 CRLF1 SON
2 geniculate ganglionitis 11.4
3 syncope 10.9
4 trigeminal neuralgia 10.6
5 hemifacial spasm 10.6
6 cardiac arrest 10.4
7 crouzon syndrome with acanthosis nigricans 10.2 CANX SON
8 syndrome of inappropriate antidiuretic hormone 10.2 POMC VIM
9 trigeminal nerve neoplasm 10.2 CRLF1 KANTR
10 multiple sclerosis 10.2
11 squamous cell carcinoma 10.2
12 neurilemmoma 10.2
13 laryngeal tuberculosis 10.2 KANTR POMC
14 neurilemmoma of the fifth cranial nerve 10.2 CRLF1 KANTR
15 thyroid crisis 10.2 KANTR POMC
16 hyperhidrosis, gustatory 10.2 CANX KANTR
17 mucinoses 10.2 POMC SRGN
18 abducens nerve disease 10.2 KANTR POMC
19 neurodermatitis 10.1 KANTR POMC
20 lateral medullary syndrome 10.1 CANX KANTR
21 premenstrual tension 10.1 KANTR POMC
22 dystonia 1, torsion, autosomal dominant 10.1 KANTR VIM
23 cardiac arrhythmia 10.1
24 facial spasm 10.1
25 lipomatosis, multiple 10.1
26 papilloma of choroid plexus 10.1
27 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
28 pleomorphic lipoma 10.1
29 tonsillitis 10.1
30 arteriovenous malformation 10.1
31 telangiectasis 10.1
32 sick sinus syndrome 10.1
33 squamous cell papilloma 10.1
34 facial paralysis 10.1
35 papilloma 10.1
36 myoepithelioma 10.1
37 myoepithelial carcinoma 10.1
38 tongue cancer 10.1
39 arachnoid cysts 10.1
40 cluster headache 10.1
41 headache 10.1
42 combined hyperactive dysfunction syndrome of the cranial nerves 10.1
43 hemidystonia 10.0 KANTR VIM
44 transient global amnesia 10.0 CRLF1 KANTR
45 cold-induced sweating syndrome 10.0 CRLF1 KANTR
46 suppurative cholangitis 9.8 CANX KANTR

Comorbidity relations with Glossopharyngeal Neuralgia via Phenotypic Disease Network (PDN):


Trigeminal Neuralgia

Graphical network of the top 20 diseases related to Glossopharyngeal Neuralgia:



Diseases related to Glossopharyngeal Neuralgia

Symptoms & Phenotypes for Glossopharyngeal Neuralgia

Drugs & Therapeutics for Glossopharyngeal Neuralgia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
2 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420

Search NIH Clinical Center for Glossopharyngeal Neuralgia

Cochrane evidence based reviews: glossopharyngeal nerve diseases

Genetic Tests for Glossopharyngeal Neuralgia

Anatomical Context for Glossopharyngeal Neuralgia

MalaCards organs/tissues related to Glossopharyngeal Neuralgia:

42
Tongue, Tonsil, Testes, Thyroid, Cortex, Heart, Trigeminal Ganglion

Publications for Glossopharyngeal Neuralgia

Articles related to Glossopharyngeal Neuralgia:

(show top 50) (show all 252)
# Title Authors Year
1
Pediatric glossopharyngeal neuralgia: a comprehensive review. ( 30361762 )
2019
2
Glossopharyngeal Neuralgia with Syncope Caused by Recurrence of Esophageal Squamous Cell Carcinoma. ( 30568145 )
2019
3
Pain-free survival after vagoglossopharyngeal complex sectioning with or without microvascular decompression in glossopharyngeal neuralgia. ( 30641844 )
2019
4
CT-guided percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective clinical study of 117 cases. ( 30708339 )
2019
5
Gradual aggravation of idiopathic glossopharyngeal neuralgia due to chronic tonsillitis: A case report. ( 31027070 )
2019
6
Glossopharyngeal neuralgia: a case report. ( 31076219 )
2019
7
The emerging role of gamma knife radiosurgery in the management of glossopharyngeal neuralgia. ( 28748271 )
2019
8
Management of Recurrent Glossopharyngeal Neuralgia Following Microvascular Decompression Surgery. ( 29960093 )
2018
9
Continuous radiofrequency thermocoagulation under CT-guidance for glossopharyngeal neuralgia: Two case reports: Erratum. ( 29979451 )
2018
10
MRI Findings and Outcomes in Patients Undergoing Microvascular Decompression for Glossopharyngeal Neuralgia. ( 30102011 )
2018
11
Glossopharyngeal Neuralgia Treatment Outcomes After Nerve Section, Microvascular Decompression, or Stereotactic Radiosurgery: A Systematic Review and Meta-Analysis. ( 30240868 )
2018
12
Does Glossopharyngeal Neuralgia Need Rhizotomy in Neurovascular Decompression Surgery? ( 30320682 )
2018
13
Does glossopharyngeal neuralgia need rhizotomy in neurovascular decompression surgery:a retrospective analysis of 37 cases. ( 30829379 )
2018
14
Continuous radiofrequency thermocoagulation under CT-guidance for glossopharyngeal neuralgia: Two case reports. ( 29901619 )
2018
15
Surgical treatment of bilateral glossopharyngeal neuralgia. ( 29888997 )
2018
16
Pulsed Radiofrequency Ablation for the Treatment of Glossopharyngeal Neuralgia Secondary to Oropharyngeal Carcinoma. ( 29871374 )
2018
17
A Case of Vago-Glossopharyngeal Neuralgia Caused by Choroid Plexus. ( 29682078 )
2018
18
Microvascular decompression for glossopharyngeal neuralgia: a retrospective analysis of 228 cases. ( 29103137 )
2018
19
The tethered effect of the arachnoid in vago-glossopharyngeal neuralgia: a real associated alternative mechanism? ( 29075903 )
2018
20
Gamma Knife radiosurgery for glossopharyngeal neuralgia: A study of 21 patients with long-term follow-up. ( 28952337 )
2018
21
Glossopharyngeal neuralgia treated by Gamma Knife radiosurgery: safety and efficacy through long-term follow-up. ( 28621622 )
2018
22
Magnetic Resonance (MR) Imaging Assessment for Glossopharyngeal Neuralgia: Value of Three-Dimensional T2-Reversed MR Imaging (3D-T2R) in Conjunction with Other Modes of 3D MR Imaging. ( 29657629 )
2017
23
A Rare Case of Glossopharyngeal Neuralgia due to Neurovascular Conflict. ( 29515426 )
2017
24
Microvascular Decompression for Glossopharyngeal Neuralgia: Clinical Analyses of 30 Cases. ( 29142635 )
2017
25
Microvascular Decompression for a Patient with a Glossopharyngeal Neuralgia: A Technical Note. ( 28948114 )
2017
26
Trigeminal Neuralgia, Glossopharyngeal Neuralgia, and Myofascial Pain Dysfunction Syndrome: An Update. ( 28827979 )
2017
27
Treatments of glossopharyngeal neuralgia: towards standard procedures. ( 28527060 )
2017
28
Recurrent syncope due to glossopharyngeal neuralgia. ( 28491772 )
2017
29
Pregabalin treatment in a pregnant woman with glossopharyngeal neuralgia. ( 28330711 )
2017
30
Microvascular Decompression for Glossopharyngeal Neuralgia: Long-Term Follow-Up. ( 28263933 )
2017
31
Neurosurgical treatment of glossopharyngeal neuralgia: analysis of 103 cases. ( 26339847 )
2016
32
Stereotactic radiosurgery for idiopathic glossopharyngeal neuralgia: an international multicenter study. ( 27903192 )
2016
33
Long-term outcomes of percutaneous radiofrequency thermocoagulation for glossopharyngeal neuralgia: A retrospective observational study. ( 27902620 )
2016
34
Microvascular decompression for glossopharyngeal neuralgia through a microasterional approach: A case series. ( 27213105 )
2016
35
Glossopharyngeal neuralgia associated with cardiac syncope. ( 27102416 )
2016
36
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. ( 26892985 )
2016
37
Microvascular decompression for glossopharyngeal neuralgia using intraoperative neurophysiological monitoring: Technical case report. ( 26862458 )
2016
38
The treatment of combined trigeminal and glossopharyngeal neuralgia by glycerol rhizolysis of the trigeminal ganglion. ( 25222621 )
2015
39
Vago-glossopharyngeal neuralgia: a literature review of neurosurgical experience. ( 25526720 )
2015
40
Glossopharyngeal neuralgia caused by a complex neurovascular conflict: Case report and review of the literature. ( 25709856 )
2015
41
Glossopharyngeal nerve contrast enhancement in recent-onset glossopharyngeal neuralgia. ( 25802271 )
2015
42
Conventional and 3-Dimensional Computerized Tomography in Eagle's Syndrome, Glossopharyngeal Neuralgia, and Asymptomatic Controls. ( 25917666 )
2015
43
The incidence of high-frequency hearing loss after microvascular decompression for trigeminal neuralgia, glossopharyngeal neuralgia, or geniculate neuralgia. ( 25932612 )
2015
44
Case report: Recurrent glossopharyngeal neuralgia after previous glossopharyngeal rhizotomy: Microvascular decompression with intra-operative neurophysiology. ( 25958960 )
2015
45
Glossopharyngeal neuralgia associated with cardiac syncope: Two case reports and literature review. ( 25974354 )
2015
46
A Perforating Artery Compressing the Nerve Rootlet and Causing Glossopharyngeal Neuralgia. ( 26103445 )
2015
47
Gamma Knife Radiosurgery for Glossopharyngeal Neuralgia by Targeting the Medial Cisternal Segment of the Glossopharyngeal Nerve: Report of 3 Cases. ( 26183516 )
2015
48
Treatment of Glossopharyngeal Neuralgia by Gamma Knife Radiosurgery. ( 26348903 )
2015
49
Classification of neurovascular compression in glossopharyngeal neuralgia: Three-dimensional visualization of the glossopharyngeal nerve. ( 26759734 )
2015
50
Use of electrophysiological monitoring in selective rhizotomy treating glossopharyngeal neuralgia. ( 24095216 )
2014

Variations for Glossopharyngeal Neuralgia

Expression for Glossopharyngeal Neuralgia

Search GEO for disease gene expression data for Glossopharyngeal Neuralgia.

Pathways for Glossopharyngeal Neuralgia

GO Terms for Glossopharyngeal Neuralgia

Biological processes related to Glossopharyngeal Neuralgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD protein signal transduction GO:0060395 9.16 HNF4A VIM
2 cytokine-mediated signaling pathway GO:0019221 9.13 CRLF1 POMC VIM
3 interleukin-27-mediated signaling pathway GO:0070106 8.62 CANX CRLF1

Sources for Glossopharyngeal Neuralgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
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34 ICD10
35 ICD10 via Orphanet
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37 IUPHAR
38 KEGG
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46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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