MCID: GLT004
MIFTS: 28

Glottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Glottis Squamous Cell Carcinoma

MalaCards integrated aliases for Glottis Squamous Cell Carcinoma:

Name: Glottis Squamous Cell Carcinoma 12 15 70
Epidermoid Carcinoma of the Glottis 12
Squamous Cell Carcinoma of Glottis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7031
NCIt 50 C8186
UMLS 70 C0280325

Summaries for Glottis Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the glottis.

MalaCards based summary : Glottis Squamous Cell Carcinoma, also known as epidermoid carcinoma of the glottis, is related to early-onset parkinson's disease and skin papilloma, and has symptoms including hoarseness An important gene associated with Glottis Squamous Cell Carcinoma is PARK7 (Parkinsonism Associated Deglycase), and among its related pathways/superpathways are Pathways of neurodegeneration - multiple diseases and Cellular Senescence (REACTOME). The drug Anesthetics has been mentioned in the context of this disorder. Affiliated tissues include glottis, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Glottis Squamous Cell Carcinoma

Diseases related to Glottis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 early-onset parkinson's disease 9.9 PTEN PARK7
2 skin papilloma 9.9 PTEN JUN
3 anaplastic ependymoma 9.9 RELA PTEN
4 pyriform sinus cancer 9.9 MAP3K5 JUN
5 ocular hypertension 9.8 PTEN JUN
6 non-alcoholic fatty liver disease 9.3 RELA MAP3K5 JUN
7 parkinson disease, late-onset 9.2 PTEN PARK7 JUN BECN1
8 disease of mental health 9.0 PTEN PARK7 JUN DAXX BECN1
9 alzheimer disease 9.0 RELA PTEN PARK7 MAP3K5 BECN1

Graphical network of the top 20 diseases related to Glottis Squamous Cell Carcinoma:



Diseases related to Glottis Squamous Cell Carcinoma

Symptoms & Phenotypes for Glottis Squamous Cell Carcinoma

UMLS symptoms related to Glottis Squamous Cell Carcinoma:


hoarseness

GenomeRNAi Phenotypes related to Glottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.43 MAP3K5
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.43 BECN1 DAXX MAP3K5 PTEN
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.43 JUN
4 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.28 BECN1 DAXX JUN PTEN
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.28 DAXX JUN MAP3K5 PTEN
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.28 JUN

MGI Mouse Phenotypes related to Glottis Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 BECN1 DAXX JUN MAP3K5 PTEN RELA
2 cellular MP:0005384 9.8 BECN1 DAXX JUN MAP3K5 PARK7 PTEN
3 embryo MP:0005380 9.55 BECN1 DAXX JUN PTEN RELA
4 nervous system MP:0003631 9.43 BECN1 DAXX JUN PARK7 PTEN RELA
5 normal MP:0002873 9.02 BECN1 DAXX JUN PTEN RELA

Drugs & Therapeutics for Glottis Squamous Cell Carcinoma

Drugs for Glottis Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter, Prospective, Randomized and Controlled Clinical Study 0f CO2 Laser and Open Surgery for T1N0 Glottic Squamous Cell Carcinoma With Anterior Commissure Involved Recruiting NCT02303457

Search NIH Clinical Center for Glottis Squamous Cell Carcinoma

Genetic Tests for Glottis Squamous Cell Carcinoma

Anatomical Context for Glottis Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Glottis Squamous Cell Carcinoma:

19
Glottis

Publications for Glottis Squamous Cell Carcinoma

Articles related to Glottis Squamous Cell Carcinoma:

# Title Authors PMID Year
1
[Supracricoid partial laryngectomy (SCPL) with either cricohyoidoepiglottopexy (CHEP): our experience with 16 cases]. 61
28904716 2017
2
Early glottic carcinoma treated by radiotherapy: defining a population for surgical salvage. 61
23007323 2013

Variations for Glottis Squamous Cell Carcinoma

Expression for Glottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Glottis Squamous Cell Carcinoma.

Pathways for Glottis Squamous Cell Carcinoma

Pathways related to Glottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 RELA PARK7 MAP3K5 DAXX BECN1
2
Show member pathways
12.9 RELA MAP3K5 JUN BECN1
3
Show member pathways
12.68 RELA PTEN MAP3K5 JUN DAXX
4 12.53 RELA MAP3K5 JUN DAXX
5
Show member pathways
12.52 RELA JUN BECN1
6
Show member pathways
12.46 RELA PTEN MAP3K5 JUN
7
Show member pathways
12.43 RELA PTEN JUN
8
Show member pathways
12.42 RELA MAP3K5 JUN DAXX
9
Show member pathways
12.41 RELA PTEN JUN
10
Show member pathways
12.4 RELA PTEN JUN
11
Show member pathways
12.33 PTEN MAP3K5 JUN
12
Show member pathways
12.33 RELA MAP3K5 JUN DAXX
13
Show member pathways
12.3 RELA PTEN JUN
14
Show member pathways
12.28 RELA PTEN JUN
15
Show member pathways
12.24 RELA PTEN JUN
16
Show member pathways
12.22 RELA MAP3K5 JUN
17 12.22 RELA MAP3K5 JUN
18
Show member pathways
12.2 RELA PTEN JUN
19 12.19 RELA JUN BECN1
20
Show member pathways
12.17 RELA PTEN MAP3K5
21 12.12 RELA PTEN JUN
22
Show member pathways
12.05 PTEN MAP3K5 BECN1
23 12.04 MAP3K5 DAXX BECN1
24
Show member pathways
11.99 RELA MAP3K5 JUN
25
Show member pathways
11.97 RELA JUN BECN1
26 11.89 RELA MAP3K5 JUN
27 11.8 RELA PTEN MAP3K5
28 11.76 RELA MAP3K5 JUN
29 11.71 PTEN JUN BECN1
30
Show member pathways
11.65 RELA MAP3K5 DAXX
31 11.62 RELA JUN DAXX
32 11.53 RELA JUN
33 11.52 RELA JUN
34
Show member pathways
11.5 RELA JUN
35
Show member pathways
11.46 RELA MAP3K5 JUN
36 11.43 PTEN JUN
37 11.4 MAP3K5 JUN
38
Show member pathways
11.4 RELA JUN
39 11.34 PTEN MAP3K5
40
Show member pathways
11.33 RELA JUN
41 11.33 RELA JUN BECN1
42 11.32 RELA JUN
43 11.28 PTEN JUN
44 11.28 RELA JUN
45 11.24 MAP3K5 DAXX
46
Show member pathways
11.17 RELA JUN DAXX
47 11.15 RELA JUN
48 11.09 RELA JUN
49 10.98 MAP3K5 JUN DAXX
50 10.98 RELA PTEN PARK7 JUN DAXX

GO Terms for Glottis Squamous Cell Carcinoma

Cellular components related to Glottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.5 RELA PTEN PARK7 MAP3K5 JUN DAXX
2 PML body GO:0016605 8.8 PTEN PARK7 DAXX

Biological processes related to Glottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.85 RELA MAP3K5 JUN DAXX
2 apoptotic process GO:0006915 9.84 PTEN MAP3K5 DAXX BECN1
3 positive regulation of apoptotic process GO:0043065 9.82 PTEN MAP3K5 JUN
4 viral process GO:0016032 9.8 RELA MAP3K5 DAXX BECN1
5 negative regulation of apoptotic process GO:0043066 9.76 RELA PTEN PARK7 BECN1
6 response to mechanical stimulus GO:0009612 9.65 RELA JUN
7 positive regulation of interleukin-8 production GO:0032757 9.65 RELA PARK7
8 response to cytokine GO:0034097 9.64 RELA JUN
9 cellular defense response GO:0006968 9.63 RELA BECN1
10 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.63 MAP3K5 JUN
11 response to cAMP GO:0051591 9.62 RELA JUN
12 cellular response to amino acid starvation GO:0034198 9.62 MAP3K5 BECN1
13 positive regulation of neuron death GO:1901216 9.61 MAP3K5 DAXX
14 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.61 RELA JUN
15 response to organic cyclic compound GO:0014070 9.61 RELA PTEN JUN
16 activation of JUN kinase activity GO:0007257 9.6 MAP3K5 DAXX
17 cellular response to reactive oxygen species GO:0034614 9.59 PARK7 JUN
18 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.58 RELA PARK7
19 cellular response to cadmium ion GO:0071276 9.58 JUN DAXX
20 negative regulation of protein catabolic process GO:0042177 9.57 RELA PARK7
21 cellular response to copper ion GO:0071280 9.56 DAXX BECN1
22 response to drug GO:0042493 9.56 RELA PTEN JUN BECN1
23 membrane depolarization GO:0051899 9.52 PARK7 JUN
24 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.51 PTEN MAP3K5
25 response to organic substance GO:0010033 9.5 RELA PTEN JUN
26 response to inorganic substance GO:0010035 9.48 RELA PTEN
27 negative regulation of protein sumoylation GO:0033234 9.4 RELA PARK7
28 cellular response to stress GO:0033554 9.37 RELA MAP3K5
29 response to hydrogen peroxide GO:0042542 9.33 RELA PARK7 JUN
30 aging GO:0007568 9.26 RELA PTEN JUN BECN1
31 cellular response to hydrogen peroxide GO:0070301 8.92 RELA PARK7 MAP3K5 BECN1

Molecular functions related to Glottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.71 RELA PARK7 MAP3K5 DAXX
2 protein-containing complex binding GO:0044877 9.67 RELA PARK7 JUN
3 identical protein binding GO:0042802 9.63 RELA PTEN PARK7 MAP3K5 JUN BECN1
4 transcription factor binding GO:0008134 9.62 RELA PARK7 JUN DAXX
5 ubiquitin protein ligase binding GO:0031625 9.56 RELA JUN DAXX BECN1
6 repressing transcription factor binding GO:0070491 9.48 RELA PARK7
7 activating transcription factor binding GO:0033613 9.46 RELA JUN
8 androgen receptor binding GO:0050681 9.43 PARK7 DAXX
9 ubiquitin-specific protease binding GO:1990381 9.37 PTEN PARK7
10 protein kinase binding GO:0019901 9.35 RELA PTEN MAP3K5 DAXX BECN1
11 enzyme binding GO:0019899 9.02 RELA PTEN PARK7 JUN DAXX

Sources for Glottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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