MCID: GLT004
MIFTS: 12

Glottis Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Glottis Squamous Cell Carcinoma

MalaCards integrated aliases for Glottis Squamous Cell Carcinoma:

Name: Glottis Squamous Cell Carcinoma 12 15 73
Epidermoid Carcinoma of the Glottis 12
Squamous Cell Carcinoma of Glottis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7031
NCIt 50 C8186
UMLS 73 C0280325

Summaries for Glottis Squamous Cell Carcinoma

MalaCards based summary : Glottis Squamous Cell Carcinoma, is also known as epidermoid carcinoma of the glottis, and has symptoms including hoarseness An important gene associated with Glottis Squamous Cell Carcinoma is HPD (4-Hydroxyphenylpyruvate Dioxygenase). The drug Anesthetics has been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Glottis Squamous Cell Carcinoma

Symptoms & Phenotypes for Glottis Squamous Cell Carcinoma

UMLS symptoms related to Glottis Squamous Cell Carcinoma:


hoarseness

GenomeRNAi Phenotypes related to Glottis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 MMP8
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.7 HPD MMP8
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.7 HPD
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.7 HPD
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.7 MMP8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.7 MMP8
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.7 MMP8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.7 HPD
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.7 HPD
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 9.7 HPD
11 Resistant to vaccinia virus (VACV-A4L) infection GR00351-A-1 8.62 HPD MMP8

Drugs & Therapeutics for Glottis Squamous Cell Carcinoma

Drugs for Glottis Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CO2 Laser and Open Surgery for T1N0 Glottic SCC With Anterior Commissure Involved Recruiting NCT02303457 Not Applicable

Search NIH Clinical Center for Glottis Squamous Cell Carcinoma

Genetic Tests for Glottis Squamous Cell Carcinoma

Anatomical Context for Glottis Squamous Cell Carcinoma

Publications for Glottis Squamous Cell Carcinoma

Variations for Glottis Squamous Cell Carcinoma

Cosmic variations for Glottis Squamous Cell Carcinoma:

9
(show all 12)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6549 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.743G>T p.R248L 17:7674220-7674220 11
2 COSM10659 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 11
3 COSM44071 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.955A>G p.K319E 17:7673573-7673573 11
4 COSM10889 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.536A>G p.H179R 17:7675076-7675076 11
5 COSM43753 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.560-1G>A p.? 17:7674972-7674972 11
6 COSM44696 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.409C>T p.L137L 17:7675203-7675203 11
7 COSM11508 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.497C>A p.S166* 17:7675115-7675115 11
8 COSM11998 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.534C>A p.H178Q 17:7675078-7675078 11
9 COSM10758 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.659A>G p.Y220C 17:7674872-7674872 11
10 COSM43947 TP53 upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 11
11 COSM522 KRAS upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.35G>C p.G12A 12:25245350-25245350 11
12 COSM12550 CDKN2A upper aerodigestive tract,glottis,carcinoma,squamous cell carcinoma c.262G>A p.E88K 9:21971097-21971097 11

Expression for Glottis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Glottis Squamous Cell Carcinoma.

Pathways for Glottis Squamous Cell Carcinoma

GO Terms for Glottis Squamous Cell Carcinoma

Sources for Glottis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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