MCID: GLC008
MIFTS: 48

Glucose Metabolism Disease

Categories: Metabolic diseases

Aliases & Classifications for Glucose Metabolism Disease

MalaCards integrated aliases for Glucose Metabolism Disease:

Name: Glucose Metabolism Disease 12 15
Glucose Metabolism Disorders 44 73
Disorder of Glucose Metabolism 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4194
MeSH 44 D044882
NCIt 50 C53655
UMLS 73 C1257958

Summaries for Glucose Metabolism Disease

MalaCards based summary : Glucose Metabolism Disease, also known as glucose metabolism disorders, is related to diabetes mellitus and prader-willi syndrome. An important gene associated with Glucose Metabolism Disease is PINK1-AS (PINK1 Antisense RNA), and among its related pathways/superpathways are Metabolism of proteins and Developmental Biology. Affiliated tissues include liver, lymph node and kidney, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Glucose Metabolism Disease

Diseases related to Glucose Metabolism Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 diabetes mellitus 31.5 ACE ADIPOQ ALB CRP DPP4 GCG
2 prader-willi syndrome 30.1 ADIPOQ GCG IGF1 INS LEP
3 gestational diabetes 30.1 ADIPOQ IAPP INS IRS1 LEP SLC2A4
4 arteries, anomalies of 30.0 ACE ADIPOQ ALB CRP INS LEP
5 coronary artery anomaly 29.9 ACE CRP IRS1
6 hypoglycemia 11.0
7 triosephosphate isomerase deficiency 11.0
8 lipodystrophy, familial partial, type 1 10.4 INS LEP PPARG
9 loeffler syndrome 10.4 ACE ALB
10 complete generalized lipodystrophy 10.4 INS LEP PPARG
11 lipodystrophy, congenital generalized, type 1 10.4 ADIPOQ INS LEP
12 malignant otitis externa 10.4 CRP INS
13 hypertensive retinopathy 10.4 ACE ADIPOQ PSMD9
14 nonalcoholic steatohepatitis 10.4 ADIPOQ INS LEP
15 microvascular complications of diabetes 3 10.4 ACE ALB INS
16 fatty liver disease, nonalcoholic 1 10.4 ADIPOQ INS LEP
17 liver disease 10.4 ADIPOQ ALB INS LEP
18 balanoposthitis 10.4 BACE1 DPP4 SLC5A2
19 mixed cell adenoma 10.4 IGF1 IRS1
20 apnea, obstructive sleep 10.4 ADIPOQ CRP INS LEP
21 severe nonproliferative diabetic retinopathy 10.4 ALB INS
22 obesity-hypoventilation syndrome 10.4 ADIPOQ LEP
23 familial partial lipodystrophy 10.4 INS LEP PPARG
24 secondary adrenal insufficiency 10.4 IGF1 INS
25 fetal macrosomia 10.4 IGF1 INS LEP
26 type 1 diabetes mellitus 15 10.4 GCG INS
27 acute insulin response 10.4 CRP GCG INS
28 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.4 CRP INS LEP SLC2A4
29 diabetic neuropathy 10.4 ACE INS LEP TRPV1
30 idiopathic edema 10.4 ACE ADIPOQ INS PPARG
31 acquired generalized lipodystrophy 10.4 ADIPOQ INS LEP PPARG
32 retinal vascular disease 10.4 ACE ALB INS PSMD9
33 sleep disorder 10.4 CRP INS LEP
34 uremia 10.4 ALB CRP INS LEP
35 acute cystitis 10.4 ALB CRP IER3IP1
36 3-hydroxyacyl-coa dehydrogenase deficiency 10.4 ADIPOQ INS LEP PPARG
37 inherited metabolic disorder 10.4 ADIPOQ CRP INS LEP
38 dysentery 10.4 ALB CRP IER3IP1
39 intermittent claudication 10.4 ACE ALB CRP
40 peripheral nervous system disease 10.4 ALB INS PSMD9 TRPV1
41 idiopathic recurrent pericarditis 10.4 ADIPOQ LEP
42 generalized atherosclerosis 10.4 ACE CRP
43 pyelonephritis 10.4 ACE ALB CRP
44 splenic abscess 10.4 CRP IER3IP1
45 immune system disease 10.4 ACE ALB CRP TRPV1
46 severe pre-eclampsia 10.4 ADIPOQ ALB LEP
47 protein-energy malnutrition 10.4 ALB IGF1 LEP
48 fatty liver disease 10.4 ADIPOQ INS IRS1 LEP
49 end stage renal failure 10.4 ACE ALB CRP LEP
50 dumping syndrome 10.4 GCG GIP INS

Graphical network of the top 20 diseases related to Glucose Metabolism Disease:



Diseases related to Glucose Metabolism Disease

Symptoms & Phenotypes for Glucose Metabolism Disease

MGI Mouse Phenotypes related to Glucose Metabolism Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ACE ADIPOQ ALB BACE1 CRP DPP4
2 growth/size/body region MP:0005378 10.25 ACE ADIPOQ BACE1 DPP4 GIP IAPP
3 adipose tissue MP:0005375 10.18 ACE ADIPOQ IGF1 INS IRS1 LEP
4 cardiovascular system MP:0005385 10.16 ACE ADIPOQ CRP IGF1 INS IRS1
5 endocrine/exocrine gland MP:0005379 10.13 ACE ADIPOQ ALB DPP4 IGF1 INS
6 immune system MP:0005387 10.1 ACE ADIPOQ CRP IAPP IGF1 INS
7 liver/biliary system MP:0005370 9.91 ACE ADIPOQ ALB INS IRS1 LEP
8 muscle MP:0005369 9.81 ADIPOQ ALB BACE1 IGF1 INS IRS1
9 neoplasm MP:0002006 9.5 ACE ADIPOQ ALB IGF1 LEP PPARG
10 renal/urinary system MP:0005367 9.28 ACE ADIPOQ ALB IGF1 INS LEP

Drugs & Therapeutics for Glucose Metabolism Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Physical Therapy in Improving the Health of Patients With Diabetic Peripheral Neuropathy Completed NCT02115932 Not Applicable

Search NIH Clinical Center for Glucose Metabolism Disease

Cochrane evidence based reviews: glucose metabolism disorders

Genetic Tests for Glucose Metabolism Disease

Anatomical Context for Glucose Metabolism Disease

MalaCards organs/tissues related to Glucose Metabolism Disease:

41
Liver, Lymph Node, Kidney, Bone, Small Intestine, Heart, Pancreas

Publications for Glucose Metabolism Disease

Articles related to Glucose Metabolism Disease:

(show all 42)
# Title Authors Year
1
Impact of Glucose Metabolism Disorders on IGF-1 Levels in Patients with Acromegaly. ( 29642245 )
2018
2
Maternal educational level and the risk of persistent post-partum glucose metabolism disorders in women with gestational diabetes mellitus. ( 29288374 )
2018
3
Dynapenic obesity as an associated factor to lipid and glucose metabolism disorders and metabolic syndrome in older adults - Findings from SABE Study. ( 28647293 )
2018
4
Salvianolate Reduces Glucose Metabolism Disorders in Dimethylnitrosamine-Induced Cirrhotic Rats. ( 29209957 )
2018
5
Detection of glucose metabolism disorders in coronary patients enrolled in cardiac rehabilitation: Is glycated haemoglobin useful? Data from the prospective REHABDIAB study. ( 29370710 )
2018
6
Potential role of liver enzyme levels as predictive markers of glucose metabolism disorders in a Tunisian population. ( 29527933 )
2018
7
Maternal lipopolysaccharide exposure results in glucose metabolism disorders and sex hormone imbalance in male offspring. ( 29614340 )
2018
8
The influence of phthalates and bisphenol A on the obesity development and glucose metabolism disorders. ( 27822670 )
2017
9
Glucose metabolism disorders in patients with non-functioning adrenal adenomas - single-centre experience. ( 28585681 )
2017
10
Gut microbiota dysbiosis associated with glucose metabolism disorders and the metabolic syndrome in older adults. ( 28701081 )
2017
11
Examining the gut bacteriome, virome, and mycobiome in glucose metabolism disorders: Are we on the right track? ( 28732571 )
2017
12
Methodological flaws in the systematic review and meta-analysis on glucose metabolism disorders in patients with primary aldosteronism. ( 25682111 )
2016
13
Glucose metabolism disorders and vestibular manifestations: evaluation through computerized dynamic posturography. ( 26631327 )
2016
14
Glucose challenge test (50-g GCT) in detection of glucose metabolism disorders in peritoneal dialysis patients: preliminary study. ( 25539618 )
2015
15
Changes in glucose metabolism in people with different glucose metabolism disorders at baseline: follow-up results of a Finnish national diabetes prevention programme. ( 25864699 )
2015
16
Visfatin concentrations in obese patients in relation to the presence of newly diagnosed glucose metabolism disorders. ( 25931039 )
2015
17
Glucose Metabolism Disorders, HIV and Antiretroviral Therapy among Tanzanian Adults. ( 26287742 )
2015
18
Preliminary Results From a Newly Established Behavioral Health Home: Early Identification of Glucose Metabolism Disorders in Individuals With Serious Mental Illness. ( 28462256 )
2015
19
Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication. ( 24704332 )
2014
20
Elevated white blood cell count is associated with higher risk of glucose metabolism disorders in middle-aged and elderly Chinese people. ( 24852600 )
2014
21
Thyroid volume in patients with glucose metabolism disorders. ( 25465604 )
2014
22
The relationship between glucose metabolism disorders and malignant thyroid disease. ( 22752254 )
2013
23
Factors associated with glucose metabolism disorders after kidney transplantation. ( 23450443 )
2013
24
Screening for people with glucose metabolism disorders within the framework of the DEMOJUAN project (DEMOnstration area for primary prevention of type 2 diabetes, JUAN Mina and Barranquilla, Colombia). ( 23996584 )
2013
25
Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet. ( 24029730 )
2013
26
Inhibition of silent information regulator 1 induces glucose metabolism disorders of hepatocytes and enhances hepatitis C virus replication. ( 26201784 )
2013
27
The prevalence and clinical characteristics of glucose metabolism disorders in patients with liver cirrhosis. A prospective study. ( 22345342 )
2012
28
Prevalence of diabetes mellitus and glucose metabolism disorders in the first degree relatives of type 2 diabetic patients. ( 22693973 )
2012
29
Glucose metabolism disorders in patients with acute coronary syndromes. ( 22920005 )
2012
30
Incidence and risk factors of glucose metabolism disorders in kidney transplant recipients: role of systematic screening by oral glucose tolerance test. ( 21336240 )
2011
31
Glucose metabolism disorders and the risk of cancer. ( 21448680 )
2011
32
Glucose metabolism disorders in cancer patients in a Chinese population. ( 19263254 )
2010
33
Antioxidants and glucose metabolism disorders. ( 20495454 )
2010
34
Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. ( 19909503 )
2009
35
[The dual (joker) function of glucose: study of its association with aging and glucose metabolism disorders]. ( 18942362 )
2008
36
Results of an international, randomized trial comparing glucose metabolism disorders and outcome with cyclosporine versus tacrolimus. ( 17359512 )
2007
37
Risk factors for glucose metabolism disorders after kidney transplantation with uneventful course. ( 18021982 )
2007
38
Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic treatment. ( 24573874 )
2007
39
Glucose metabolism disorders improvement in patients with thalassaemia major after 24-36 months of intensive chelation therapy. ( 16462711 )
2004
40
[Role of the steroids, SHBG, IGF-1, IGF BP-3 and growth hormone in glucose metabolism disorders during long-term treatment with low doses of glucocorticoids]. ( 11925670 )
2002
41
The effects of high haematocrit levels on glucose metabolism disorders. ( 12235927 )
2002
42
Serum paraoxonase and cholinesterase activities in individuals with lipid and glucose metabolism disorders. ( 8393741 )
1993

Variations for Glucose Metabolism Disease

Expression for Glucose Metabolism Disease

Search GEO for disease gene expression data for Glucose Metabolism Disease.

Pathways for Glucose Metabolism Disease

Pathways related to Glucose Metabolism Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 ACE BACE1 DPP4 GCG GIP IAPP
2
Show member pathways
13.38 ADIPOQ IAPP INS IRS1 LEP PPARG
3
Show member pathways
12.65 ADIPOQ INS IRS1 LEP SLC2A4
4 12.36 ADIPOQ GCG INS IRS1 PPARG SLC2A4
5
Show member pathways
12.22 ADIPOQ IGF1 INS IRS1 LEP PPARG
6
Show member pathways
12.07 INS IRS1 LEP SLC2A4
7
Show member pathways
11.96 ACE DPP4 GCG GIP IGF1 INS
8
Show member pathways
11.95 IGF1 INS IRS1 SLC2A4
9
Show member pathways
11.95 ADIPOQ IGF1 INS IRS1 PPARG
10
Show member pathways
11.81 INS IRS1 SLC2A4
11
Show member pathways
11.74 ADIPOQ INS IRS1 SLC2A4
12 11.57 ADIPOQ IRS1 LEP SLC2A4
13
Show member pathways
11.45 DPP4 GCG GIP LEP
14 11.44 IRS1 LEP SLC2A4
15 11.4 INS IRS1 LEP
16 11.29 ADIPOQ IGF1 INS IRS1 LEP PPARG
17 11.24 IGF1 INS IRS1
18 11.05 ADIPOQ LEP PPARG
19 10.8 INS SLC2A4
20
Show member pathways
10.79 IRS1 SLC2A4
21 10.7 ADIPOQ IRS1 LEP PPARG SLC2A4

GO Terms for Glucose Metabolism Disease

Cellular components related to Glucose Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ACE ADIPOQ ALB CRP DPP4 GCG
2 endoplasmic reticulum lumen GO:0005788 9.55 ALB BACE1 GCG GIP INS
3 extracellular space GO:0005615 9.32 ACE ADIPOQ ALB CRP GCG GIP

Biological processes related to Glucose Metabolism Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.83 ALB BACE1 IAPP IGF1 INS
2 positive regulation of protein kinase B signaling GO:0051897 9.81 IAPP INS IRS1 LEP
3 response to nutrient GO:0007584 9.79 ADIPOQ LEP PPARG
4 positive regulation of MAPK cascade GO:0043410 9.78 IAPP IGF1 INS LEP
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 IGF1 INS LEP
6 cellular response to insulin stimulus GO:0032869 9.76 ADIPOQ IRS1 PPARG SLC2A4
7 regulation of blood pressure GO:0008217 9.75 ACE LEP PPARG
8 glucose metabolic process GO:0006006 9.74 ADIPOQ INS LEP
9 response to nutrient levels GO:0031667 9.73 ADIPOQ GIP LEP
10 response to peptide hormone GO:0043434 9.71 GIP IRS1 TRPV1
11 sensory perception of pain GO:0019233 9.7 GIP IAPP TRPV1
12 regulation of signaling receptor activity GO:0010469 9.7 ADIPOQ GCG GIP IAPP IGF1 INS
13 positive regulation of cellular protein metabolic process GO:0032270 9.65 ADIPOQ INS
14 regulation of fat cell differentiation GO:0045598 9.65 LEP PPARG
15 fatty acid oxidation GO:0019395 9.64 ADIPOQ PPARG
16 negative regulation of gluconeogenesis GO:0045721 9.64 ADIPOQ INS
17 amyloid-beta metabolic process GO:0050435 9.63 ACE BACE1
18 insulin-like growth factor receptor signaling pathway GO:0048009 9.62 IGF1 IRS1
19 regulation of insulin secretion GO:0050796 9.62 DPP4 GCG GIP LEP
20 negative regulation of blood vessel diameter GO:0097756 9.61 CRP INS
21 positive regulation of protein kinase A signaling GO:0010739 9.61 ADIPOQ IAPP
22 regulation of fatty acid biosynthetic process GO:0042304 9.6 ADIPOQ GIP
23 negative regulation of lipid storage GO:0010888 9.58 CRP LEP
24 positive regulation of glycogen biosynthetic process GO:0045725 9.58 IGF1 INS IRS1
25 negative regulation of acute inflammatory response GO:0002674 9.55 INS PPARG
26 positive regulation of insulin receptor signaling pathway GO:0046628 9.54 INS IRS1 LEP
27 bone mineralization involved in bone maturation GO:0035630 9.49 IGF1 LEP
28 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.43 ADIPOQ CRP PPARG
29 positive regulation of glucose import GO:0046326 9.26 ADIPOQ IGF1 INS IRS1
30 glucose homeostasis GO:0042593 9.1 ADIPOQ INS IRS1 LEP PPARG SLC2A4
31 positive regulation of cell proliferation GO:0008284 10.03 DPP4 IGF1 INS IRS1 LEP

Molecular functions related to Glucose Metabolism Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 ADIPOQ DPP4 GCG IAPP LEP
2 identical protein binding GO:0042802 9.61 ADIPOQ ALB CRP DPP4 GCG IAPP
3 drug binding GO:0008144 9.54 ACE ALB PPARG
4 insulin receptor binding GO:0005158 9.43 IGF1 INS IRS1
5 dipeptidyl-peptidase activity GO:0008239 9.4 ACE DPP4
6 insulin-like growth factor receptor binding GO:0005159 9.33 IGF1 INS IRS1
7 hormone activity GO:0005179 9.17 ADIPOQ GCG GIP IAPP IGF1 INS

Sources for Glucose Metabolism Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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