MCID: GLY022
MIFTS: 30

Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Categories: Rare diseases

Aliases & Classifications for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

MalaCards integrated aliases for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency:

Name: Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency 54 74
Glyceraldehyde-3-Phosphate Dehydrogenase 13
Gapdh Deficiency 54

Classifications:



External Ids:

UMLS 74 C1291264

Summaries for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

MalaCards based summary : Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency, also known as glyceraldehyde-3-phosphate dehydrogenase, is related to neutrophil actin dysfunction and hypoxia. The drugs Tacrolimus and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include liver, testis and lung.

Wikipedia : 77 Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or less commonly as G3PDH) (EC 1.2.1.12)... more...

Related Diseases for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Diseases related to Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 neutrophil actin dysfunction 10.6
2 hypoxia 10.4
3 alzheimer disease 10.4
4 hepatitis 10.4
5 hepatocellular carcinoma 10.3
6 prostate cancer 10.3
7 aging 10.3
8 hepatitis b 10.3
9 melanoma 10.3
10 ischemia 10.3
11 breast cancer 10.2
12 ovarian cancer 10.2
13 prostate cancer, hereditary, 8 10.2
14 prostate cancer, hereditary, 6 10.2
15 dengue virus 10.2
16 multiple sclerosis 10.1
17 polycythemia vera 10.1
18 thyroid dyshormonogenesis 1 10.1
19 thyroid dyshormonogenesis 3 10.1
20 hepatitis c virus 10.1
21 malaria 10.1
22 hepatitis c 10.1
23 adenocarcinoma 10.1
24 intestinal volvulus 10.1
25 neuropathy 10.1
26 hereditary spherocytosis 10.0
27 diabetes mellitus, noninsulin-dependent 10.0
28 renal cell carcinoma, nonpapillary 10.0
29 spinocerebellar ataxia 1 10.0
30 small cell cancer of the lung 10.0
31 suppressor of tumorigenicity 3 10.0
32 lung cancer 10.0
33 neuroblastoma 1 10.0
34 mycobacterium tuberculosis 1 10.0
35 noonan syndrome 5 10.0
36 microvascular complications of diabetes 5 10.0
37 dehydrated hereditary stomatocytosis 2 10.0
38 arthritis 10.0
39 diabetes mellitus 10.0
40 liver cirrhosis 10.0
41 pancreas adenocarcinoma 10.0
42 intestinal schistosomiasis 10.0
43 sleeping sickness 10.0
44 cerebral artery occlusion 10.0
45 mastitis 10.0
46 filariasis 10.0
47 japanese encephalitis 10.0
48 hepatitis a 10.0
49 dementia 10.0
50 schistosomiasis 10.0

Graphical network of the top 20 diseases related to Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency:



Diseases related to Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Symptoms & Phenotypes for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Drugs & Therapeutics for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Drugs for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 3 104987-11-3 6473866 445643 439492
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
4
Mycophenolic acid Approved Phase 3 24280-93-1 446541
5
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
8
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
9
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
10 Autonomic Agents Phase 3
11 Neuroprotective Agents Phase 3
12 Antineoplastic Agents, Hormonal Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Methylprednisolone Acetate Phase 3
16 Immunosuppressive Agents Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Antitubercular Agents Phase 3
19 Dermatologic Agents Phase 3
20 Antifungal Agents Phase 3
21 Antirheumatic Agents Phase 3
22 Calcineurin Inhibitors Phase 3
23 Anti-Infective Agents Phase 3,Phase 2
24 Gastrointestinal Agents Phase 3
25 Cyclosporins Phase 3
26 Immunologic Factors Phase 3
27 Anti-Bacterial Agents Phase 3,Phase 2
28 Antiemetics Phase 3
29 glucocorticoids Phase 3
30 Protective Agents Phase 3
31 Anti-Inflammatory Agents Phase 3
32 Hormones Phase 3,Phase 2
33 Hormone Antagonists Phase 3
34 Prednisolone acetate Phase 3
35
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
36
Pemetrexed Approved, Investigational Phase 2 150399-23-8, 137281-23-3 60843 446556
37
leucovorin Approved Phase 2 58-05-9 143 6006
38
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
39
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 5280795 6221
40
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
41
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
43 Micronutrients Phase 2
44 Vitamins Phase 2
45 Vitamin D2 Phase 2
46 Nutrients Phase 2
47 Bone Density Conservation Agents Phase 2
48 Calcium, Dietary Phase 2
49 Ergocalciferols Phase 2
50 Trace Elements Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Canadian Cardiology de Novo Study: A Comparison Between Tacrolimus- and Cyclosporine- Based Immunoprophylactic Regimens Completed NCT00157014 Phase 3 Tacrolimus;Cyclosporine;Mycophenolate mofetil;Methylprednisolone;Prednisone
2 Analysis of Response of Subjects With Atopic Dermatitis or Psoriasis to Oral Vitamin D3 Completed NCT00789880 Phase 2 Vitamin D3;Placebo
3 Study Tests The Safety And Effectiveness Of SU011248 In Patients With Non-Small Cell Lung Cancer Having Brain Metastases Completed NCT00372775 Phase 2 Sunitinib
4 Dosage Schedule Study of Pemetrexed Monochemotherapy for Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Completed NCT00370292 Phase 2 Pemetrexed - Before Protocol Amendment;Pemetrexed - After Protocol Amendment
5 Clinical Endpoint Trial Investigating Once Daily and Bronchodilator Dosing Completed NCT00549744 Phase 2 GSK256066
6 Gamma Secretase Inhibitor PF-03084014 in Treating Patients With AIDS-Associated Kaposi Sarcoma Withdrawn NCT02137564 Phase 2 gamma secretase inhibitor PF-03084014
7 Ephrin B1 Regulation in Human Right Appendage Completed NCT01080781
8 Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers Completed NCT01541826 Not Applicable
9 Molecular Biological and Moleculargenetic Monitoring of Therapy After Kidney Transplantation Recruiting NCT01515605
10 Long-term Endogenous Androgen Priming in Bologna Criteria Poor Responder Patients - A Pilot Study Recruiting NCT03447184 Androgen priming
11 Detection of Peritoneal Micrometastasis in Gastric and Pancreatic Cancer in Peritoneal Wash Samples Active, not recruiting NCT00582062

Search NIH Clinical Center for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Genetic Tests for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Anatomical Context for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

MalaCards organs/tissues related to Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency:

42
Liver, Testis, Lung, Brain, Kidney, Skeletal Muscle, Prostate

Publications for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Articles related to Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency:

(show top 50) (show all 1947)
# Title Authors Year
1
Dengue virus nonstructural 3 protein interacts directly with human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and reduces its glycolytic activity. ( 30804377 )
2019
2
Regulation of glyceraldehyde-3-phosphate dehydrogenase by hypoxia inducible factor 1 in the white shrimp Litopenaeus vannamei during hypoxia and reoxygenation. ( 31100464 )
2019
3
Moonlighting Protein Glyceraldehyde-3-Phosphate Dehydrogenase: A Cellular Rapid-Response Molecule for Maintenance of Iron Homeostasis in Hypoxia. ( 30897319 )
2019
4
Expression of glyceraldehyde-3-phosphate dehydrogenase from M. tuberculosis in E. coli. Purification and characteristics of the untagged recombinant enzyme. ( 30710621 )
2019
5
The Plastidial Glyceraldehyde-3-Phosphate Dehydrogenase Is Critical for Abiotic Stress Response in Wheat. ( 30836662 )
2019
6
The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding. ( 30863383 )
2019
7
Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro. ( 30996801 )
2019
8
Extracellular transglycosylase and glyceraldehyde-3-phosphate dehydrogenase attributed to the anti-staphylococcal activity of Lactobacillus plantarum USM8613. ( 31095980 )
2019
9
A dedicated glyceraldehyde-3-phosphate dehydrogenase is involved in the biosynthesis of volatile sesquiterpenes in Trichoderma virens-evidence for the role of a fungal GAPDH in secondary metabolism. ( 30046843 )
2019
10
Cloning and Expression Profile of Glyceraldehyde-3-Phosphate Dehydrogenase in Haemaphysalis flava (Acari: Ixodidae). ( 30418636 )
2019
11
Organization of multi-binding to host proteins: The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Mycoplasma pneumoniae. ( 30454655 )
2019
12
Glyceraldehyde-3-phosphate dehydrogenase from Citrobacter sp. S-77 is post-translationally modified by CoA (protein CoAlation) under oxidative stress. ( 30652074 )
2019
13
Glycation of α-synuclein amplifies the binding with glyceraldehyde-3-phosphate dehydrogenase. ( 30658140 )
2019
14
Identification and characterization of glyceraldehyde 3-phosphate dehydrogenase from Fasciola gigantica. ( 30706165 )
2019
15
Expression, purification and characterisation of chondroitinase AC II with glyceraldehyde-3-phosphate dehydrogenase tag and chaperone (GroEs-GroEL) from Arthrobacter sp. CS01. ( 30763643 )
2019
16
Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis. ( 30831195 )
2019
17
The glyceraldehyde-3-phosphate dehydrogenase of the shrimp Litopenaeus vannamei: Molecular cloning, characterization and expression during hypoxia. ( 29699713 )
2018
18
Protein S-Bacillithiolation Functions in Thiol Protection and Redox Regulation of the Glyceraldehyde-3-Phosphate Dehydrogenase Gap in Staphylococcus aureus Under Hypochlorite Stress. ( 27967218 )
2018
19
Pcal_0632, a phosphorylating glyceraldehyde-3-phosphate dehydrogenase from Pyrobaculum calidifontis. ( 29177716 )
2018
20
Kinetic regime of aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle. ( 29183722 )
2018
21
Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase. ( 29298351 )
2018
22
Binding of alpha-synuclein to partially oxidized glyceraldehyde-3-phosphate dehydrogenase induces subsequent inactivation of the enzyme. ( 29408361 )
2018
23
Fates of Evolutionarily Distinct, Plastid-type Glyceraldehyde 3-phosphate Dehydrogenase Genes in Kareniacean Dinoflagellates. ( 29478272 )
2018
24
Cryptic Disorder Out of Disorder: Encounter between Conditionally Disordered CP12 and Glyceraldehyde-3-Phosphate Dehydrogenase. ( 29501381 )
2018
25
Structural studies of glyceraldehyde-3-phosphate dehydrogenase from Naegleria gruberi, the first one from phylum Percolozoa. ( 29501559 )
2018
26
High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase. ( 29633972 )
2018
27
Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade. ( 29664161 )
2018
28
A cryoprotectant induces conformational change in glyceraldehyde-3-phosphate dehydrogenase. ( 29717994 )
2018
29
Interaction between adenylate kinase 3 and glyceraldehyde-3-phosphate dehydrogenase from Chlamydomonas reinhardtii. ( 29727516 )
2018
30
Expression of glyceraldehyde-3-phosphate dehydrogenase on the surface of Clostridium perfringens cells. ( 29753109 )
2018
31
Influence of Oxidative Stress on Catalytic and Non-glycolytic Functions of Glyceraldehyde-3-phosphate dehydrogenase. ( 29848267 )
2018
32
Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. ( 30012884 )
2018
33
Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases. ( 30209795 )
2018
34
Agrobacterium-mediated transformation of the ascomycete mushroom Morchella importuna using polyubiquitin and glyceraldehyde-3-phosphate dehydrogenase promoter-based binary vectors. ( 30218324 )
2018
35
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weight compounds in counteracting its aggregation and nuclear translocation. ( 30254002 )
2018
36
Citrus tristeza virus co-opts glyceraldehyde 3-phosphate dehydrogenase for its infectious cycle by interacting with the viral-encoded protein p23. ( 30392159 )
2018
37
From the Cover: Alcohol Inhibition of the Enzymatic Activity of Glyceraldehyde 3-Phosphate Dehydrogenase Impairs Cardiac Glucose Utilization, Contributing to Alcoholic Cardiomyopathy. ( 28962519 )
2017
38
Moonlighting glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is required for efficient hepatitis C virus and dengue virus infections in human Huh-7.5.1 cells. ( 28548037 )
2017
39
Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa. ( 27080476 )
2017
40
Detection of a mutation in the intron of Sperm-specific glyceraldehyde-3-phosphate dehydrogenase gene in patients with fibrous sheath dysplasia of the sperm flagellum. ( 27135296 )
2017
41
Glyceraldehyde-3-phosphate dehydrogenase: Aggregation mechanisms and impact on amyloid neurodegenerative diseases. ( 27215901 )
2017
42
Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression. ( 27878251 )
2017
43
Identifying Glyceraldehyde 3-Phosphate Dehydrogenase as a Cyclic Adenosine Diphosphoribose Binding Protein by Photoaffinity Protein-Ligand Labeling Approach. ( 27936653 )
2017
44
Overexpression of the triose phosphate translocator (TPT) complements the abnormal metabolism and development of plastidial glycolytic glyceraldehyde-3-phosphate dehydrogenase mutants. ( 27984670 )
2017
45
Molecular basis for covalent inhibition of glyceraldehyde-3-phosphate dehydrogenase by a 2-phenoxy-1,4-naphthoquinone small molecule. ( 28079302 )
2017
46
Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death. ( 28167533 )
2017
47
S100B impairs glycolysis via enhanced poly(ADP-ribosyl)ation of glyceraldehyde-3-phosphate dehydrogenase in rodent muscle cells. ( 28174179 )
2017
48
Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism. ( 28258188 )
2017
49
D-Glyceraldehyde-3-Phosphate Dehydrogenase Structure and Function. ( 28271485 )
2017
50
Moonlighting glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH): an evolutionarily conserved plasminogen receptor on mammalian cells. ( 28298336 )
2017

Variations for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Expression for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Search GEO for disease gene expression data for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency.

Pathways for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

GO Terms for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

Sources for Glyceraldehyde-3-Phosphate Dehydrogenase Deficiency

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