Glycine N-Methyltransferase Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Glycine N-Methyltransferase Deficiency

MalaCards integrated aliases for Glycine N-Methyltransferase Deficiency:

Name: Glycine N-Methyltransferase Deficiency ⁵⁷ ¹² ²⁰ ⁵⁸ ⁷² ²⁹ ¹³ ⁶ ¹⁵ ³⁹ ⁷⁰

Gnmt Deficiency ⁵⁷ ¹² ²⁰ ⁷² ⁵⁴

Hypermethioninemia Due to Glycine N-Methyltransferase Deficiency ¹² ²⁰ ⁵⁸

Hypermethioninemia Due to Gnmt Deficiency ¹² ²⁰ ⁵⁸

Hypermethioninemia ⁷² ⁷⁰

Hepatic Methionine Adenosyltransferase Deficiency ⁷⁰

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Inheritance:
autosomal recessive

HPO:

³¹

glycine n-methyltransferase deficiency:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Metabolic diseases
Anatomical: Liver diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Endocrine, nutritional and metabolic diseases

Metabolic disorders

Other disorders of amino-acid metabolism

Disorders of sulfur-bearing amino-acid metabolism

Orphanet: ⁵⁸

Inborn errors of metabolism

External Ids:

Disease Ontology ¹² DOID:0111037

OMIM® ⁵⁷ 606664

ICD10 ³² E72.1

ICD10 via Orphanet ³³ E72.1

UMLS via Orphanet ⁷¹ C1847720

Orphanet ⁵⁸ ORPHA289891

MedGen ⁴¹ C1847720

SNOMED-CT via HPO ⁶⁸ 124283007 166603001 166643006 more

UMLS ⁷⁰ C0268621 C1847720 C4048705

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Summaries for Glycine N-Methyltransferase Deficiency

GARD : ²⁰ Glycine N-methyltransferase deficiency (GNMT deficiency) is a very rare condition characterized by persistent and isolated excess levels of methionine in the blood (hypermethioninemia). The only clinical abnormalities are mild increase of the liver size (hepatomegaly) and chronic elevation of the transaminase levels in the blood without liver disease. Methionine may also be increased in urine. However, because elevated levels of methionine in the blood itself is a risk factor for development of neurological signs and symptoms, people with GNMT deficiency can have neurological problems when methionine levels are greater than 800 ?mol/L. GNMT deficiency is caused by mutations in the GNMT gene. Inheritance is autosomal recessive. Treatment is not needed in most cases.

MalaCards based summary : Glycine N-Methyltransferase Deficiency, also known as gnmt deficiency, is related to hypermethioninemia and methionine adenosyltransferase i/iii deficiency. An important gene associated with Glycine N-Methyltransferase Deficiency is GNMT (Glycine N-Methyltransferase), and among its related pathways/superpathways are Metabolism and Folate Metabolism. Affiliated tissues include liver and nk cells, and related phenotypes are hepatomegaly and elevated hepatic transaminase

Disease Ontology : ¹² A hypermethioninemia characterized by autosomal recessive inheritance of persistent isolated hypermethioninemia without cystathionine beta-synthase deficiency, tyrosinemia type I, or liver disease that has material basis in homozygous or compound heterozygous mutation in the GNMT gene on chromosome 6p21.

UniProtKB/Swiss-Prot : ⁷² Glycine N-methyltransferase deficiency: The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.

Wikipedia : ⁷³ Hypermethioninemia is an excess of the amino acid methionine, in the blood. This condition can occur... more...

More information from OMIM: 606664

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Related Diseases for Glycine N-Methyltransferase Deficiency

Diseases related to Glycine N-Methyltransferase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	hypermethioninemia	31.5	MAT2A MAT1A GNMT CBS BHMT AHCY
2	methionine adenosyltransferase i/iii deficiency	30.4	MAT1A CBS
3	homocystinuria	30.3	MTHFR MAT1A CBS BHMT
4	homocysteinemia	29.8	MTHFR CBS BHMT AHCY
5	hypermethioninemia due to adenosine kinase deficiency	11.7
6	hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	11.7
7	methionine adenosyltransferase deficiency	11.0
8	fatty liver disease	10.3
9	homocystinuria due to cystathionine beta-synthase deficiency	10.2
10	tyrosinemia	10.2
11	alpha-methylacetoacetic aciduria	10.2
12	hypertrichosis universalis congenita, ambras type	10.1	MAT2A MAT1A
13	type 2 diabetes mellitus	10.1
14	niemann-pick disease, type c2	10.1
15	non-alcoholic fatty liver disease	10.1
16	glucose intolerance	10.1
17	liver disease	10.1
18	cholestasis	10.1
19	choline deficiency disease	10.0	MTHFR BHMT AHCY
20	methylmalonic acidemia and homocysteinemia, cblx type	10.0	MTHFR BHMT
21	amino acid metabolic disorder	10.0	MTHFR BHMT AHCY
22	biliary atresia	10.0
23	inherited metabolic disorder	10.0
24	dimethylglycine dehydrogenase deficiency	10.0	SARDH DMGDH
25	lens subluxation	9.9	MTHFR CBS
26	sarcosinemia	9.9	SARDH DMGDH
27	myositis	9.8
28	triiodothyronine receptor auxiliary protein	9.8
29	phenylketonuria	9.8
30	tyrosinemia, type i	9.8
31	autosomal recessive non-syndromic intellectual disability	9.8
32	obstructive jaundice	9.8
33	toxic shock syndrome	9.8
34	vascular disease	9.8
35	pharyngitis	9.8
36	liver cirrhosis	9.8
37	impetigo	9.8
38	mitochondrial disorders	9.8
39	biliary hypoplasia	9.8
40	chromosomal triplication	9.8
41	encephalopathy	9.8
42	hypotonia	9.8
43	streptococcal toxic-shock syndrome	9.8

Graphical network of the top 20 diseases related to Glycine N-Methyltransferase Deficiency:

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Symptoms & Phenotypes for Glycine N-Methyltransferase Deficiency

Human phenotypes related to Glycine N-Methyltransferase Deficiency:

³¹

#	Description	HPO Source Accession
1	hepatomegaly ³¹	HP:0002240
2	elevated hepatic transaminase ³¹	HP:0002910
3	hypermethioninemia ³¹	HP:0003235

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Abdomen Liver:
hepatomegaly

Laboratory Abnormalities:
hypermethioninemia
elevated transaminases

Clinical features from OMIM®:

606664 (Updated 05-Apr-2021)

MGI Mouse Phenotypes related to Glycine N-Methyltransferase Deficiency:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system	MP:0005370	9.23	ADK BHMT GNMT MAT1A MTAP MTHFR

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Drugs & Therapeutics for Glycine N-Methyltransferase Deficiency

Search Clinical Trials , NIH Clinical Center for Glycine N-Methyltransferase Deficiency

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Genetic Tests for Glycine N-Methyltransferase Deficiency

Genetic tests related to Glycine N-Methyltransferase Deficiency:

#	Genetic test	Affiliating Genes
1	Glycine N-Methyltransferase Deficiency ²⁹	GNMT

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Anatomical Context for Glycine N-Methyltransferase Deficiency

MalaCards organs/tissues related to Glycine N-Methyltransferase Deficiency:

⁴⁰

Liver, Nk Cells

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Publications for Glycine N-Methyltransferase Deficiency

Articles related to Glycine N-Methyltransferase Deficiency:

(show all 21)

#	Title	Authors	PMID	Year
1	Glycine N -methyltransferase deficiency: a new patient with a novel mutation. ²⁰ ⁵⁴ ⁶ ⁵⁷ ⁶¹	Augoustides-Savvopoulou P...Mudd SH	14739680	2003
2	Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. ⁶¹ ⁵⁴ ⁶ ⁵⁷	Mudd SH...Wagner C	11596649	2001
3	Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. ⁵⁷ ⁶	Luka Z...Wagner C	11810299	2002
4	Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. ⁵⁴ ⁵⁷	Liu SP...Chen YM	17937387	2007
5	Glycine N-Methyltransferase Deficiency: A Member of Dysmethylating Liver Disorders? ²⁰ ⁶¹	Baric I...Fumic K	27207470	2017
6	Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders. ²⁰	Baric I...Blom HJ	27671891	2017
7	Inherited disorders in the conversion of methionine to homocysteine. ⁶¹ ⁵⁴	Baric I	19585268	2009
8	Characterization of reduced expression of glycine N-methyltransferase in cancerous hepatic tissues using two newly developed monoclonal antibodies. ⁵⁴ ⁶¹	Liu HH...Chen YM	12566990	2003
9	Familial hypermethioninemia partially responsive to dietary restriction. ²⁰	Labrune P...Odievre M	2380820	1990
10	Targeted and untargeted metabolomics provide insight into the consequences of glycine-N-methyltransferase deficiency including the novel finding of defective immune function. ⁶¹	Eudy BJ...da Silva RP	32951289	2020
11	Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma. ⁶¹	Chen M...Chen YA	31170416	2019
12	MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis. ⁶¹	Fernandez-Ramos D...Martinez-Chantar ML	30237481	2018
13	Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver. ⁶¹	Liao YJ...Chen YA	27716281	2016
14	Methionine and S-adenosylmethionine levels are critical regulators of PP2A activity modulating lipophagy during steatosis. ⁶¹	Zubiete-Franco I...Varela-Rey M	26394163	2016
15	Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis. ⁶¹	Li CH...Chen YM	25535034	2015
16	TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. ⁶¹	Fernandez-Alvarez S...Beraza N	25531568	2015
17	The multi-functional roles of GNMT in toxicology and cancer. ⁶¹	Yen CH...Chen YM	23147572	2013
18	Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. ⁶¹	Liao YJ...Chen YM	22183894	2012
19	Hypermethioninemias of genetic and non-genetic origin: A review. ⁶¹	Mudd SH	21308989	2011
20	Deficiency of glycine N-methyltransferase results in deterioration of cellular defense to stress in mouse liver. ⁶¹	Liao YJ...Chen YM	21137059	2010
21	Methyl balance and transmethylation fluxes in humans. ⁶¹	Mudd SH...Wagner C	17209172	2007

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Genes for Glycine N-Methyltransferase Deficiency

Genes related to Glycine N-Methyltransferase Deficiency (3 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	GNMT	Glycine N-Methyltransferase	Protein Coding	1698.8	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative germline mutation (loss of function) ⁵⁸ Causative variation ⁷² Genetic Tests ²⁹ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Variants (show sections)	11596649 11810299 19585268 (more) 14739680 17937387 12566990
2	CNPY3-GNMT	CNPY3-GNMT Readthrough	Protein Coding	417.42	Pathogenic ⁶ GeneCards inferred via : Publications Variants (show sections)	11596649 11810299
3	PEX6	Peroxisomal Biogenesis Factor 6	Protein Coding	407.62	Pathogenic ⁶ GeneCards inferred via : Variants (show sections)	11810299
4	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	13.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	MAT2A	Methionine Adenosyltransferase 2A	Protein Coding	13.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	12.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	NPC2	NPC Intracellular Cholesterol Transporter 2	Protein Coding	11.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	AHCY	Adenosylhomocysteinase	Protein Coding	7.05	DISEASES inferred ¹⁵
9	ADPRH	ADP-Ribosylarginine Hydrolase	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
10	CBS	Cystathionine Beta-Synthase	Protein Coding	6.98	GeneCards inferred via : Publications (show sections)
11	FTCD	Formimidoyltransferase Cyclodeaminase	Protein Coding	6.41	DISEASES inferred ¹⁵
12	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	5.95	DISEASES inferred ¹⁵
13	SARDH	Sarcosine Dehydrogenase	Protein Coding	5.58	DISEASES inferred ¹⁵
14	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	5.54	DISEASES inferred ¹⁵
15	ST20-MTHFS	ST20-MTHFS Readthrough	Protein Coding	5.46	DISEASES inferred ¹⁵
16	LCMT1	Leucine Carboxyl Methyltransferase 1	Protein Coding	5.44	DISEASES inferred ¹⁵
17	DMGDH	Dimethylglycine Dehydrogenase	Protein Coding	5.41	DISEASES inferred ¹⁵
18	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	5.37	DISEASES inferred ¹⁵
19	PREX2	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2	Protein Coding	5.29	DISEASES inferred ¹⁵
20	ADK	Adenosine Kinase	Protein Coding	5.24	DISEASES inferred ¹⁵

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Variations for Glycine N-Methyltransferase Deficiency

ClinVar genetic disease variations for Glycine N-Methyltransferase Deficiency:

⁶

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	CNPY3-GNMT , GNMT	NM_018960.6(GNMT):c.149T>C (p.Leu50Pro)	SNV	Pathogenic	4169	rs121907888	GRCh37: 6:42928654-42928654 GRCh38: 6:42960916-42960916
2	CNPY3-GNMT , GNMT	NM_018960.6(GNMT):c.422A>G (p.Asn141Ser)	SNV	Pathogenic	218931	rs864321678	GRCh37: 6:42930587-42930587 GRCh38: 6:42962849-42962849
3	PEX6 , CNPY3-GNMT , GNMT	NM_018960.6(GNMT):c.529C>A (p.His177Asn)	SNV	Pathogenic	4170	rs121907889	GRCh37: 6:42930887-42930887 GRCh38: 6:42963149-42963149
4	CNPY3-GNMT , GNMT	NM_018960.6(GNMT):c.888_*3del (p.Ter296CysextTer?)	Deletion	Pathogenic	1030685		GRCh37: 6:42931442-42931445 GRCh38: 6:42963704-42963707
5	CNPY3-GNMT , GNMT	NM_018960.6(GNMT):c.454G>A (p.Asp152Asn)	SNV	Uncertain significance	1030683		GRCh37: 6:42930812-42930812 GRCh38: 6:42963074-42963074
6	CNPY3-GNMT , GNMT	NM_018960.6(GNMT):c.469C>T (p.Arg157Trp)	SNV	Uncertain significance	1030684		GRCh37: 6:42930827-42930827 GRCh38: 6:42963089-42963089

UniProtKB/Swiss-Prot genetic disease variations for Glycine N-Methyltransferase Deficiency:

⁷²

#	Symbol	AA change	Variation ID	SNP ID
1	GNMT	p.Leu50Pro	VAR_012766	rs121907888
2	GNMT	p.His177Asn	VAR_012767	rs121907889
3	GNMT	p.Asn141Ser	VAR_019840	rs864321678

Sources

Expression for Glycine N-Methyltransferase Deficiency

Search GEO for disease gene expression data for Glycine N-Methyltransferase Deficiency.

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Pathways for Glycine N-Methyltransferase Deficiency

Pathways related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁵ Show member pathways Metabolic pathways ³⁶ Metabolism of lipids and lipoproteins ⁶⁵	13.75	ST20-MTHFS SARDH NPC2 MTHFR MTAP MAT2A
2	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.07	MTHFR MAT1A CBS AHCY
3	Carbon metabolism ³⁶ Show member pathways 2-Oxocarboxylic acid metabolism ³⁶ Biosynthesis of amino acids ³⁶ formaldehyde oxidation ¹	12.03	MTHFR MAT2A MAT1A CBS
4	Amino Acid metabolism ¹	11.59	FTCD CBS BHMT
5	Sulfur amino acid metabolism ⁶⁵ Show member pathways Cysteine and methionine metabolism ³⁶ Degradation of cysteine and homocysteine ⁶⁵ L-serine degradation ¹ methionine salvage cycle III ¹ Methionine salvage pathway ⁶⁵ S-methyl-5-thioadenosine degradation ¹ spermidine biosynthesis ¹ Sulfide oxidation to sulfate ⁶⁵ sulfite oxidation ¹ taurine biosynthesis ¹ Trans-sulfuration pathway ¹ Valine, leucine and isoleucine biosynthesis ³⁶	11.53	MTAP MAT2A MAT1A CBS BHMT AHCY
6	One carbon pool by folate ³⁶ Show member pathways Antimetabolite Pathway - Folate Cycle, Pharmacodynamics ⁶⁰ dTMP de novo biosynthesis (mitochondrial) ¹ folate transformations I ¹ Methionine metabolism ²³ methionine salvage ¹ Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics ⁶⁰ One Carbon Metabolism ¹ tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate ¹ Trans-sulfuration and one carbon metabolism ¹	11.38	ST20-MTHFS MTHFR MAT2A MAT1A FTCD CBS
7	Glycine, serine and threonine metabolism ³⁶ Show member pathways glycine betaine degradation ¹ superpathway of choline degradation to L-serine ¹	11.27	SARDH GNMT DMGDH CBS BHMT
8	superpathway of methionine degradation ¹ Show member pathways 2-oxobutanoate degradation ¹ 2-oxoisovalerate decarboxylation to isobutanoyl-CoA ¹ cysteine biosynthesis ¹ L-cysteine degradation I ¹	10.96	MAT2A MAT1A CBS
9	S-adenosyl-L-methionine biosynthesis ¹ Show member pathways methionine degradation ¹ Methylation Pathways ¹	10.68	MAT2A MAT1A
10	Folate-Alcohol and Cancer Pathway ¹	10.27	MTHFR CBS

Sources

GO Terms for Glycine N-Methyltransferase Deficiency

Cellular components related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	9.5	SOCS2 PREX2 PEX6 MTHFR MTAP MAT2A

Biological processes related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein modification process	GO:0006464	9.7	LCMT1 GNMT ADPRH
2	one-carbon metabolic process	GO:0006730	9.62	MAT2A MAT1A GNMT AHCY
3	protein methylation	GO:0006479	9.54	LCMT1 BHMT
4	methionine biosynthetic process	GO:0009086	9.51	MTHFR BHMT
5	tetrahydrofolate interconversion	GO:0035999	9.49	MTHFR FTCD
6	homocysteine metabolic process	GO:0050667	9.48	MTHFR CBS
7	methionine metabolic process	GO:0006555	9.46	MTHFR GNMT
8	purine ribonucleoside salvage	GO:0006166	9.43	MTAP ADK
9	S-adenosylmethionine metabolic process	GO:0046500	9.43	MTHFR GNMT BHMT
10	S-adenosylmethionine biosynthetic process	GO:0006556	9.4	MAT2A MAT1A
11	amino-acid betaine catabolic process	GO:0006579	9.37	DMGDH BHMT
12	choline catabolic process	GO:0042426	9.33	SARDH DMGDH BHMT
13	sulfur amino acid metabolic process	GO:0000096	9.13	MAT1A BHMT AHCY
14	methylation	GO:0032259	9.1	MAT2A MAT1A LCMT1 GNMT BHMT AHCY

Molecular functions related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transferase activity	GO:0016740	9.61	SARDH MTAP MAT2A MAT1A LCMT1 GNMT
2	S-adenosyl-L-methionine binding	GO:1904047	9.32	GNMT CBS
3	folic acid binding	GO:0005542	9.26	GNMT FTCD
4	modified amino acid binding	GO:0072341	9.16	MTHFR CBS
5	methionine adenosyltransferase activity	GO:0004478	8.62	MAT2A MAT1A

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Sources for Glycine N-Methyltransferase Deficiency

¹ BioSystems

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³ CDC

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¹⁰ dbSNP

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²⁵ GeneReviews

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²⁷ GEO DataSets

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Glycine N-Methyltransferase Deficiency (GNMT DEFICIENCY)

Aliases & Classifications for Glycine N-Methyltransferase Deficiency

MalaCards integrated aliases for Glycine N-Methyltransferase Deficiency:

Characteristics:

OMIM®:

HPO:

Classifications:

External Ids:

Summaries for Glycine N-Methyltransferase Deficiency

Related Diseases for Glycine N-Methyltransferase Deficiency

Diseases related to Glycine N-Methyltransferase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Glycine N-Methyltransferase Deficiency:

Symptoms & Phenotypes for Glycine N-Methyltransferase Deficiency

Human phenotypes related to Glycine N-Methyltransferase Deficiency:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

MGI Mouse Phenotypes related to Glycine N-Methyltransferase Deficiency:

Drugs & Therapeutics for Glycine N-Methyltransferase Deficiency

Genetic Tests for Glycine N-Methyltransferase Deficiency

Genetic tests related to Glycine N-Methyltransferase Deficiency:

Anatomical Context for Glycine N-Methyltransferase Deficiency

MalaCards organs/tissues related to Glycine N-Methyltransferase Deficiency:

Publications for Glycine N-Methyltransferase Deficiency

Articles related to Glycine N-Methyltransferase Deficiency:

Genes for Glycine N-Methyltransferase Deficiency

Genes related to Glycine N-Methyltransferase Deficiency (3 elite genes):

Variations for Glycine N-Methyltransferase Deficiency

ClinVar genetic disease variations for Glycine N-Methyltransferase Deficiency:

UniProtKB/Swiss-Prot genetic disease variations for Glycine N-Methyltransferase Deficiency:

Expression for Glycine N-Methyltransferase Deficiency

Pathways for Glycine N-Methyltransferase Deficiency

Pathways related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

GO Terms for Glycine N-Methyltransferase Deficiency

Cellular components related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

Biological processes related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

Molecular functions related to Glycine N-Methyltransferase Deficiency according to GeneCards Suite gene sharing:

Sources for Glycine N-Methyltransferase Deficiency