MCID: GNT004
MIFTS: 28

Gnathomiasis

Categories: Eye diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Gnathomiasis

MalaCards integrated aliases for Gnathomiasis:

Name: Gnathomiasis 12 15 17
Gnathostomiasis 12 3 44 70 32
Infectious Disease by Gnathostoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11379
ICD9CM 34 128.1
MeSH 44 D058429
NCIt 50 C128395
SNOMED-CT 67 44086001
ICD10 32 B83.1
UMLS 70 C0018013

Summaries for Gnathomiasis

CDC : 3 Gnathostoma spinigerumHuman gnathostomiasis is caused by several species of parasitic worms (nematodes) in the genus Gnathostoma. The disease is found and is most commonly diagnosed in Southeast Asia, though it has also been found elsewhere in Asia, in South and Central America, and in some areas of Africa. People become infected primarily by eating undercooked or raw freshwater fish, eels, frogs, birds, and reptiles. The most common manifestations of the infection in humans are migratory swellings under the skin and increased levels of eosinophils in the blood. Rarely, the parasite can enter other tissues such as the liver, and the eye, resulting in vision loss or blindness, and the nerves, spinal cord, or brain, resulting in nerve pain, paralysis, coma and death.

MalaCards based summary : Gnathomiasis, also known as gnathostomiasis, is related to parasitic helminthiasis infectious disease and sparganosis. An important gene associated with Gnathomiasis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways is tRNA Aminoacylation. Affiliated tissues include eye, spinal cord and skin.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.

Related Diseases for Gnathomiasis

Diseases related to Gnathomiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 parasitic helminthiasis infectious disease 30.0 TES MT-CO1
2 sparganosis 29.9 TES MT-CO1
3 gnathostoma infection 11.5
4 hypereosinophilic syndrome 10.5
5 panniculitis 10.3
6 cutaneous larva migrans 10.3
7 ancylostomiasis 10.2 TES MT-CO1
8 uveitis 10.2
9 hymenolepiasis 10.2 TES MT-CO1
10 enterobiasis 10.1 TES MT-CO1
11 paragonimiasis 10.1 TES MT-CO1
12 taeniasis 10.1 TES MT-CO1
13 echinostomiasis 10.1 MT-TE MT-CO1
14 strongyloidiasis 10.1 TES MT-CO1
15 iridocyclitis 10.0
16 toxocariasis 10.0
17 mitochondrial myopathy, infantile, transient 10.0 MT-TE MT-CO1
18 osteogenesis imperfecta, type xvii 10.0 SPTB MT-CO1
19 diphyllobothriasis 10.0 MT-TS2 MT-CO1
20 pthirus pubis infestation 10.0 MT-TE MT-CO1
21 papillomatosis, confluent and reticulated 10.0
22 disease by infectious agent 10.0
23 angiostrongyliasis 10.0
24 exanthem 10.0
25 myelitis 10.0
26 paraplegia 10.0
27 appendicitis 10.0
28 lice infestation 10.0 MT-TE MT-CO1
29 parasitic ectoparasitic infectious disease 9.9 MT-TE MT-CO1
30 dicrocoeliasis 9.9 MT-TS2 MT-TE
31 intestinal impaction 9.8 MT-TY MT-TN
32 pneumothorax, primary spontaneous 9.8
33 schistosoma mansoni infection, susceptibility/ 9.8
34 yemenite deaf-blind hypopigmentation syndrome 9.8
35 ifap syndrome 2 9.8
36 cysticercosis 9.8
37 pleurisy 9.8
38 meningoencephalitis 9.8
39 cauda equina syndrome 9.8
40 panuveitis 9.8
41 branch retinal artery occlusion 9.8
42 diarrhea 9.8
43 multiple cranial nerve palsy 9.8
44 schistosomiasis 9.8
45 pyuria 9.8
46 urticaria 9.8
47 angioedema 9.8
48 pneumothorax 9.8
49 pericarditis 9.8
50 optic nerve disease 9.8

Graphical network of the top 20 diseases related to Gnathomiasis:



Diseases related to Gnathomiasis

Symptoms & Phenotypes for Gnathomiasis

Drugs & Therapeutics for Gnathomiasis

Search Clinical Trials , NIH Clinical Center for Gnathomiasis

Cochrane evidence based reviews: gnathostomiasis

Genetic Tests for Gnathomiasis

Anatomical Context for Gnathomiasis

MalaCards organs/tissues related to Gnathomiasis:

40
Eye, Spinal Cord, Skin, Colon, Cervix, Monocytes, Nk Cells

Publications for Gnathomiasis

Articles related to Gnathomiasis:

(show top 50) (show all 374)
# Title Authors PMID Year
1
Gnathostomiasis in a traveller returning from Madagascar. 61
33748851 2021
2
The occurrence and clinical importance of infectious stage of Echinocephalus (Nematoda: Gnathostomidae) larvae in selected Australian edible fish. 61
33731302 2021
3
Human gnathostomiasis: a neglected food-borne zoonosis. 61
33298141 2020
4
AcanR3990 qPCR: a novel, highly sensitive, bioinformatically-informed assay to detect Angiostrongylus cantonensis infections. 61
33252651 2020
5
Ocular Sparganosis: The First Report of Spirometra ranarum in Thailand. 61
33202511 2020
6
Ocular Gnathostomiasis Presenting as Branch Retinal Artery Occlusion. 61
32990490 2020
7
Intraocular gnathostomiasis and central serous chorioretinopathy. 61
32506596 2020
8
Case Report: The First Direct Evidence of Gnathostoma spinigerum Migration through Human Lung. 61
32588815 2020
9
Autochthonous Gnathostomiasis in Madagascar. 61
32687036 2020
10
Larval Gnathostomes and Spargana in Chinese Edible Frogs, Hoplobatrachus rugulosus, from Myanmar: Potential Risk of Human Infection. 61
32871642 2020
11
An autochthonous case of gnathostomiasis in the United States. 61
32258314 2020
12
Cutaneous gnathostomiasis in Vietnam. 61
32092150 2020
13
Molecular cloning and characterization of serine protease inhibitor from food-borne nematode, Gnathostoma spinigerum. 61
31811864 2020
14
Effects of Gnathostoma spinigerum infective stage larva excretory-secretory products on NK cells in peripheral blood mononuclear cell culture: focused on expressions of IFN-γ and killer cell lectin-like receptors. 61
31932913 2020
15
Gnathostomiasis Acquired by Visitors to the Okavango Delta, Botswana. 61
32155896 2020
16
Molecular Identification of the Etiological Agent of Human Gnathostomiasis in an Endemic Area of Mexico. 61
31564694 2020
17
Gnathostomiasis acquired after consumption of raw freshwater fish in the Amazon region: a report of two cases in Brazil. 61
33206877 2020
18
Emerging infections: mimickers of common patterns seen in dermatopathology. 61
31685961 2020
19
Percutaneous Emergence of Gnathostoma spinigerum Following Praziquantel Treatment. 61
31847422 2019
20
Application of Recombinant Angiostrongylus cantonensis Galectin-2 Protein for Serodiagnosis of Human Angiostrongyliasis by Immunoblotting. 61
31392957 2019
21
First record of the nematode Echinocephalus pseudouncinatus (Gnathostomatidae, Spirurida) in an edible, commercial host, the pen shell Atrina maura (Bivalvia: Pinnidae). 61
31541623 2019
22
[Migratory vulvitis caused by imported gnathostomiasis]. 61
31859811 2019
23
Two cases of cutaneous gnathostomiasis after eating raw Salangichthys microdon (icefish, shirauo). 61
31245862 2019
24
Morphological and molecular characteristics of adult worms of Gnathostoma Owen, 1836 (Nematoda) collected from domestic pigs in Dien Bien Province, northern Vietnam. 61
31490126 2019
25
Molecular identification and genetic diversity of Gnathostoma spinigerum larvae in freshwater fishes in southern Lao PDR, Cambodia, and Myanmar. 61
30911911 2019
26
Transcriptome and excretory-secretory proteome of infective-stage larvae of the nematode Gnathostoma spinigerum reveal potential immunodiagnostic targets for development. 61
31166909 2019
27
Role of Ultra-Wide-Field Imaging in the Diagnosis of Intravitreal Gnathostomiasis: A Case Report. 61
30096004 2019
28
A filtration-based rapid test using a partially purified third-stage larval antigen to detect specific antibodies for the diagnosis of gnathostomiasis. 61
29144215 2019
29
VISCERAL GNATHOSTOMIASIS WITH SIMULTANEOUS DAMAGE TO THE UPPER AND LOWER PARTS OF THE GASTROINTESTINAL TRACT. 61
30516495 2018
30
Case Report: Ocular Gnathostomiasis in Venezuela Most Likely Acquired in Texas. 61
30141392 2018
31
Immunochromatographic test for rapid serological diagnosis of human angiostrongyliasis. 61
29908250 2018
32
An Overview of Fish-borne Nematodiases among Returned Travelers for Recent 25 Years- Unexpected Diseases Sometimes Far Away from the Origin. 61
29996625 2018
33
Gnathostomiasis: an emerging infectious disease relevant to all dermatologists. 61
33287961 2018
34
Gnathostomiasis: an emerging infectious disease relevant to all dermatologists. 61
29723377 2018
35
Imported gnathostomiasis manifesting as cutaneous larva migrans and Löffler's syndrome. 61
29420245 2018
36
Sushi, ceviche and gnathostomiasis - A case report and review of imported infections. 61
29050898 2017
37
Case Report: Clinical Features of Intermittent Migratory Swelling Caused by Gnathostomiasis with Complete Follow-up. 61
28820693 2017
38
Genetic diversity of infective larvae of Gnathostoma spinigerum (Nematoda: Gnathostomatidae) in freshwater swamp eels from Thailand. 61
27890039 2017
39
Excretory-secretory product of third-stage Gnathostoma spinigerum larvae induces apoptosis in human peripheral blood mononuclear cells. 61
28836111 2017
40
Ocular Gnathostomiasis-Update of Earlier Survey. 61
28722600 2017
41
Gnathostomiasis caused by ingestion of raw Oncorhynchus masou ishikawae roe. 61
28470869 2017
42
Molecular identification of Gnathostoma spinigerum (Nematoda: Gnathostomatidae) as causative agent of human gnathostomiasis in Thailand. 61
33593032 2017
43
Cross-reactivity of the 31 kDa antigen of Angiostrongylus cantonensis - Dealing with the immunodiagnosis of meningoencephalitis. 61
27866477 2017
44
Complete mitochondrial genomes of Gnathostoma nipponicum and Gnathostoma sp., and their comparison with other Gnathostoma species. 61
28025097 2017
45
Spinal Gnathostomiasis: A Case Report with Magnetic Resonance Imaging and Electrophysiological Findings. 61
29953176 2016
46
Thoracic Myelopathy Due to Gnathostomiasis Acquired in New Zealand. 61
27402520 2016
47
The complete mitochondrial genomes of Gnathostoma doloresi from China and Japan. 61
27301404 2016
48
Cross-Reactivity Pattern of Asian and American Human Gnathostomiasis in Western Blot Assays Using Crude Antigens Prepared from Gnathostoma spinigerum and Gnathostoma binucleatum Third-Stage Larvae. 61
27325806 2016
49
Gnathostomiasis in Brazil: an emerging disease with a challenging diagnosis. 61
27799501 2016
50
Ocular Gnathostomiasis in Brazil: A Case Report. 61
27239465 2016

Variations for Gnathomiasis

Expression for Gnathomiasis

Search GEO for disease gene expression data for Gnathomiasis.

Pathways for Gnathomiasis

Pathways related to Gnathomiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.17 MT-TY MT-TS2 MT-TN MT-TE

GO Terms for Gnathomiasis

Biological processes related to Gnathomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 8.62 PRDX6 MT-CO1

Sources for Gnathomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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