MCID: GNT004
MIFTS: 31

Gnathomiasis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Gnathomiasis

MalaCards integrated aliases for Gnathomiasis:

Name: Gnathomiasis 12 15 17
Gnathostomiasis 12 45 74 3
Infectious Disease by Gnathostoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11379
ICD9CM 36 128.1
MeSH 45 D058429
NCIt 51 C128395
SNOMED-CT 69 44086001
ICD10 34 B83.1
UMLS 74 C0018013

Summaries for Gnathomiasis

CDC : 3 Human gnathostomiasis is caused by several species of parasitic worms (nematodes) in the genus Gnathostoma. The disease is found and is most commonly diagnosed in Southeast Asia, though it has also been found elsewhere in Asia, in South and Central America, and in some areas of Africa. People become infected primarily by eating undercooked or raw freshwater fish, eels, frogs, birds, and reptiles. The most common manifestations of the infection in humans are migratory swellings under the skin and increased levels of eosinophils in the blood. Rarely, the parasite can enter other tissues such as the liver, and the eye, resulting in vision loss or blindness, and the nerves, spinal cord, or brain, resulting in nerve pain, paralysis, coma and death.

MalaCards based summary : Gnathomiasis, also known as gnathostomiasis, is related to gnathostoma infection and panniculitis. An important gene associated with Gnathomiasis is SPTB (Spectrin Beta, Erythrocytic), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Ca, cAMP and Lipid Signaling. Affiliated tissues include skin, brain and liver.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.

Related Diseases for Gnathomiasis

Graphical network of the top 20 diseases related to Gnathomiasis:



Diseases related to Gnathomiasis

Symptoms & Phenotypes for Gnathomiasis

Drugs & Therapeutics for Gnathomiasis

Search Clinical Trials , NIH Clinical Center for Gnathomiasis

Cochrane evidence based reviews: gnathostomiasis

Genetic Tests for Gnathomiasis

Anatomical Context for Gnathomiasis

MalaCards organs/tissues related to Gnathomiasis:

42
Skin, Brain, Liver, Eye, Spinal Cord, Testes, Colon

Publications for Gnathomiasis

Articles related to Gnathomiasis:

(show top 50) (show all 180)
# Title Authors Year
1
A filtration-based rapid test using a partially purified third-stage larval antigen to detect specific antibodies for the diagnosis of gnathostomiasis. ( 29144215 )
2019
2
Gnathostomiasis: an emerging infectious disease relevant to all dermatologists. ( 29723377 )
2018
3
Role of Ultra-Wide-Field Imaging in the Diagnosis of Intravitreal Gnathostomiasis: A Case-Report. ( 30096004 )
2018
4
Case Report: Ocular Gnathostomiasis in Venezuela Most Likely Acquired in Texas. ( 30141392 )
2018
5
VISCERAL GNATHOSTOMIASIS WITH SIMULTANEOUS DAMAGE TO THE UPPER AND LOWER PARTS OF THE GASTROINTESTINAL TRACT. ( 30516495 )
2018
6
Gnathostomiasis caused by ingestion of raw Oncorhynchus masou ishikawae roe. ( 28470869 )
2017
7
Ocular Gnathostomiasis-Update of Earlier Survey. ( 28722600 )
2017
8
Case Report: Clinical Features of Intermittent Migratory Swelling Caused by Gnathostomiasis with Complete Follow-up. ( 28820693 )
2017
9
Sushi, ceviche and gnathostomiasis - A case report and review of imported infections. ( 29050898 )
2017
10
Development and usefulness of an immunochromatographic device to detect antibodies for rapid diagnosis of human gnathostomiasis. ( 26754616 )
2016
11
Intraocular gnathostomiasis: A rare case report from Central India. ( 27146938 )
2016
12
Ocular Gnathostomiasis in Brazil: A Case Report. ( 27239465 )
2016
13
Cross-Reactivity Pattern of Asian and American Human Gnathostomiasis in Western Blot Assays Using Crude Antigens Prepared from Gnathostoma spinigerum and Gnathostoma binucleatum Third-Stage Larvae. ( 27325806 )
2016
14
Thoracic Myelopathy Due to Gnathostomiasis Acquired in New Zealand. ( 27402520 )
2016
15
Gnathostomiasis in Brazil: an emerging disease with a challenging diagnosis. ( 27799501 )
2016
16
Spinal Gnathostomiasis: A Case Report with Magnetic Resonance Imaging and Electrophysiological Findings. ( 29953176 )
2016
17
Spinal epidural hematoma and gnathostomiasis. ( 25834033 )
2015
18
Gnathostomiasis: An Emerging Infection of Raw Fish Consumers in Gnathostoma Nematode-Endemic and Nonendemic Countries. ( 25997919 )
2015
19
Three Human Gnathostomiasis Cases in Thailand with Molecular Identification of Causative Parasite Species. ( 26055743 )
2015
20
Dermoscopic features of cutaneous gnathostomiasis. ( 26095309 )
2015
21
Increasing Risk Factors for Imported and Domestic Gnathostomiasis in the United States. ( 27159596 )
2015
22
Asymptomatic eosinophilia due to gnathostomiasis. ( 24657582 )
2014
23
Diagnosis of gnathostomiasis by skin testing using partially purified specific antigen and total IgE levels. ( 24463581 )
2014
24
Subarachnoid hemorrhage due to vascular causes and gnathostomiasis: clinical features and laboratory findings. ( 25417497 )
2014
25
A dot-ELISA test using a Gnathostoma spinigerum recombinant matrix metalloproteinase protein for the serodiagnosis of human gnathostomiasis. ( 25417498 )
2014
26
Cutaneous gnathostomiasis: report of 6 cases with emphasis on histopathological demonstration of the larva. ( 22940406 )
2013
27
Application of recombinant Gnathostoma spinigerum matrix metalloproteinase-like protein for serodiagnosis of human gnathostomiasis by immunoblotting. ( 23716413 )
2013
28
Intraocular gnathostomiasis from coastal part of Maharashtra. ( 23961449 )
2013
29
Gnathostomiasis and sushi ingestion. ( 22407066 )
2012
30
Imported intraocular gnathostomiasis with subretinal tracks confirmed by western blot assay. ( 22451738 )
2012
31
Intraocular gnathostomiasis: report of a case and review of literature. ( 22492146 )
2012
32
Characterization of the humoral immune response against Gnathostoma binucleatum in patients clinically diagnosed with gnathostomiasis. ( 22665606 )
2012
33
Autochthonous gnathostomiasis, Brazil. ( 23171480 )
2012
34
Gnathostomiasis in remote northern Western Australia: the first confirmed cases acquired in Australia. ( 21728942 )
2011
35
Gnathostomiasis in a patient who frequently consumes sushi. ( 22024572 )
2011
36
Sero-epidemiological survey of gnathostomiasis in Lao PDR. ( 20804856 )
2010
37
Predictive factors for Gnathostoma seropositivity in patients visiting the Gnathostomiasis Clinic at the Hospital for Tropical Diseases, Thailand during 2000-2005. ( 21329304 )
2010
38
Sequential imaging studies of cerebral gnathostomiasis with subdural hemorrhage as its complication. ( 18951600 )
2009
39
Long-term follow-up of imported gnathostomiasis shows frequent treatment failure. ( 19141836 )
2009
40
Short report: case of gnathostomiasis in Beijing, China. ( 19190210 )
2009
41
Gnathostomiasis acquired by British tourists in Botswana. ( 19331741 )
2009
42
Gnathostomiasis, another emerging imported disease. ( 19597010 )
2009
43
Hypereosinophilia and abdominopulmonary gnathostomiasis. ( 19058571 )
2008
44
Intravitreal gnathostomiasis and review of literature. ( 17218918 )
2007
45
Evaluation of human IgG class and subclass antibodies to a 24 kDa antigenic component of Gnathostoma spinigerum for the serodiagnosis of gnathostomiasis. ( 17468971 )
2007
46
Gnathostomiasis of the anterior chamber. ( 17901651 )
2007
47
Gnathostomiasis: a rare nematode infection. ( 16467775 )
2006
48
Gnathostomiasis: import from Laos. ( 16686609 )
2006
49
Orbital apex syndrome from gnathostomiasis. ( 16966936 )
2006
50
Efficacy of ivermectin treatment of cutaneous gnathostomiasis evaluated by placebo-controlled trial. ( 17120960 )
2006

Variations for Gnathomiasis

Expression for Gnathomiasis

Search GEO for disease gene expression data for Gnathomiasis.

Pathways for Gnathomiasis

Pathways related to Gnathomiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 CD40 FCGR1A PTCRA
2 11.24 ANXA5 PRDX6 SAG
3
Show member pathways
10.9 CD40 CTSL FCGR1A

GO Terms for Gnathomiasis

Molecular functions related to Gnathomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.4 ANXA5 CD40 CTSL FCGR1A LGALS3BP MT-CO1

Sources for Gnathomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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