MCID: GNT004
MIFTS: 24

Gnathomiasis

Categories: Infectious diseases

Aliases & Classifications for Gnathomiasis

MalaCards integrated aliases for Gnathomiasis:

Name: Gnathomiasis 12 15
Gnathostomiasis 12 3 44 73
Infectious Disease by Gnathostoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11379
ICD10 33 B83.1
ICD9CM 35 128.1
MeSH 44 D058429
SNOMED-CT 68 44086001
UMLS 73 C0018013

Summaries for Gnathomiasis

CDC : 3 Human gnathostomiasis is caused by several species of parasitic worms (nematodes) in the genus Gnathostoma. The disease is found and is most commonly diagnosed in Southeast Asia, though it has also been found elsewhere in Asia, in South and Central America, and in some areas of Africa. People become infected primarily by eating undercooked or raw freshwater fish, eels, frogs, birds, and reptiles. The most common manifestations of the infection in humans are migratory swellings under the skin and increased levels of eosinophils in the blood. Rarely, the parasite can enter other tissues such as the liver, and the eye, resulting in vision loss or blindness, and the nerves, spinal cord, or brain, resulting in nerve pain, paralysis, coma and death.

MalaCards based summary : Gnathomiasis, also known as gnathostomiasis, is related to gnathostoma infection and sparganosis. An important gene associated with Gnathomiasis is SPTB (Spectrin Beta, Erythrocytic), and among its related pathways/superpathways is Transcriptional misregulation in cancer. Affiliated tissues include skin, liver and spinal cord, and related phenotypes are immune system and normal

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis.

Related Diseases for Gnathomiasis

Graphical network of the top 20 diseases related to Gnathomiasis:



Diseases related to Gnathomiasis

Symptoms & Phenotypes for Gnathomiasis

MGI Mouse Phenotypes related to Gnathomiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 ANXA5 CD40 FCGR1A LGALS3BP MT-CO1 PTCRA
2 normal MP:0002873 9.17 ANXA5 CD40 FCGR1A PRDX6 SERPINB6 SNAI1

Drugs & Therapeutics for Gnathomiasis

Search Clinical Trials , NIH Clinical Center for Gnathomiasis

Cochrane evidence based reviews: gnathostomiasis

Genetic Tests for Gnathomiasis

Anatomical Context for Gnathomiasis

MalaCards organs/tissues related to Gnathomiasis:

41
Skin, Liver, Spinal Cord, Brain, Eye

Publications for Gnathomiasis

Variations for Gnathomiasis

Expression for Gnathomiasis

Search GEO for disease gene expression data for Gnathomiasis.

Pathways for Gnathomiasis

Pathways related to Gnathomiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 CD40 FCGR1A PTCRA

GO Terms for Gnathomiasis

Cellular components related to Gnathomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 ANGPTL6 ANXA5 CD40 CTSL LGALS3BP PRDX6

Molecular functions related to Gnathomiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.44 ANXA5 CD40 CTSL FCGR1A LGALS3BP MT-CO1

Sources for Gnathomiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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