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GCC
MCID: GBL002
MIFTS: 32

Goblet Cell Carcinoid (GCC)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Goblet Cell Carcinoid

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MalaCards integrated aliases for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 20 58
Goblet Cell Adenocarcinoid 20 58
Goblet Cell Carcinoma 20 58
Goblet Cell Tumor 20 58
Gcc 20 58
Carcinoid, Goblet Cell 70
Carcinoid Goblet Cell 54
Mucinous Carcinoid 20

Characteristics:

Orphanet epidemiological data:

58
goblet cell carcinoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare gastroenterological diseases
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 33 C18.1
UMLS via Orphanet 71 C0205695
Orphanet 58 ORPHA329984
UMLS 70 C0205695
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Summaries for Goblet Cell Carcinoid

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GARD : 20 Goblet cell carcinoid (GCC) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. It is usually diagnosed in people over the age of 50. People with this tumor may develop acute appendicitis, abdominal pain, and diarrhea. Prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. Treatment involves surgery to remove the tumor. Depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries (in women). Some people will have chemotherapy after surgery.

MalaCards based summary : Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to carcinoid syndrome and cystadenoma. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways/superpathways are WNT Signaling and Arf6 trafficking events. Affiliated tissues include appendix, colon and lymph node.

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Related Diseases for Goblet Cell Carcinoid

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Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 31.4 ENO2 CHGA
2 cystadenoma 30.4 KRT20 CHGA
3 appendix adenocarcinoma 30.4 KRT20 CHGA
4 rectum adenocarcinoma 30.0 KRT20 CTNNB1
5 signet ring cell adenocarcinoma 29.9 KRT20 CTNNB1 CHGA CDH1
6 mucinous cystadenocarcinoma 29.9 KRT20 CEACAM7
7 pseudomyxoma peritonei 29.8 KRT20 CTNNB1 CDH1
8 colorectal adenocarcinoma 29.8 KRT20 CTNNB1 CDH1
9 neuroendocrine tumor 29.8 KRT20 GAST ENO2 CHGA
10 carcinoid tumors, intestinal 29.6 GAST ENO2 CHGA
11 cystic teratoma 29.6 KRT20 ENO2
12 papillary carcinoma 29.4 KRT20 CHGA CDH1
13 colon adenocarcinoma 29.2 KRT20 CTNNB1 CEACAM7 CDH1
14 teratoma 28.9 KRT20 ENO2 CTNNB1 CHGA CDH1
15 neuroendocrine carcinoma 28.9 KRT20 GAST ENO2 CHGA CDH1
16 glassy cell carcinoma of the cervix 11.0
17 appendicitis 10.8
18 rare tumor 10.6
19 adenocarcinoma 10.5
20 appendiceal neoplasm 10.4
21 mucinous adenocarcinoma 10.4
22 ganglioneuroma 10.2 ENO2 CHGA
23 vaginal glandular tumor 10.2 ENO2 CHGA
24 ureter transitional cell carcinoma 10.2 ENO2 CHGA
25 auditory system benign neoplasm 10.2 ENO2 CHGA
26 auditory system cancer 10.2 ENO2 CHGA
27 cauda equina neoplasm 10.2 ENO2 CHGA
28 ampulla of vater benign neoplasm 10.2 ENO2 CHGA
29 appendix carcinoid tumor 10.2 ENO2 CHGA
30 carotid body cancer 10.2 ENO2 CHGA
31 gallbladder small cell carcinoma 10.2 ENO2 CHGA
32 ureter small cell carcinoma 10.2 ENO2 CHGA
33 middle ear adenoma 10.2 ENO2 CHGA
34 nodular ganglioneuroblastoma 10.2 ENO2 CHGA
35 schistosoma mansoni infection, susceptibility/ 10.2
36 appendix cancer 10.2
37 leiomyoma 10.2
38 schistosomiasis 10.2
39 peritonitis 10.2
40 ileus 10.2
41 neurofibromatosis 10.2
42 gastric small cell carcinoma 10.2 ENO2 CHGA
43 extracranial neuroblastoma 10.2 ENO2 CHGA
44 ewing sarcoma of bone 10.2 ENO2 CHGA
45 vulvar intraepithelial neoplasia 10.2 CTNNB1 CDH1
46 sensory organ benign neoplasm 10.2 ENO2 CHGA
47 cervical neuroblastoma 10.2 ENO2 CHGA
48 gastric hemangioma 10.2 ENO2 CHGA
49 subependymoma 10.2 ENO2 CHGA
50 pineocytoma 10.2 ENO2 CHGA

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to Goblet Cell Carcinoid
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Symptoms & Phenotypes for Goblet Cell Carcinoid

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Drugs & Therapeutics for Goblet Cell Carcinoid

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Search Clinical Trials , NIH Clinical Center for Goblet Cell Carcinoid

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Genetic Tests for Goblet Cell Carcinoid

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Anatomical Context for Goblet Cell Carcinoid

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MalaCards organs/tissues related to Goblet Cell Carcinoid:

40
Appendix, Colon, Lymph Node, Ovary
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Publications for Goblet Cell Carcinoid

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Articles related to Goblet Cell Carcinoid:

(show top 50) (show all 223)
# Title Authors PMID Year
1
Goblet cell carcinoid of the appendix: a specific type of carcinoma. 61 54
18042066 2007
2
Composite glandular-endocrine cell carcinoma of the stomach. Report of two cases with goblet cell carcinoid component. 61 54
15792127 2005
3
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin. 61 54
11350611 2001
4
Histologic and racial/ethnic patterns of appendiceal cancer among young patients. 61
33795212 2021
5
Is adjuvant chemotherapy beneficial for stage II-III goblet cell carcinoid/goblet cell adenocarcinoma of the appendix? 61
33360118 2021
6
Appendiceal Goblet Cell Adenocarcinoma Case Report and Review of the Literature. 61
33786220 2021
7
The 2019 World Health Organization Classification of appendiceal, colorectal and anal canal tumours: an update and critical assessment. 61
33461799 2021
8
Why did they change that? Practical implications of the evolving classification of neuroendocrine tumours of the gastrointestinal tract. 61
33382490 2021
9
ASO Author Reflections: Impact of Adjuvant Chemotherapy After Right Hemicolectomy for Appendiceal Goblet Cell Carcinoid. 61
33389287 2021
10
Advanced appendiceal goblet cell carcinoids with intestinal obstruction: two case reports. 61
32989687 2020
11
Molecular Characterization of Appendiceal Goblet Cell Carcinoid. 61
33037134 2020
12
[More than Four-Year Survival of Appendiceal Adenocarcinoma Due to Goblet Cell Carcinoid and Manifesting as an Abdominal Tumor and Hydronephrosis]. 61
33468946 2020
13
Duodenal Obstruction Caused by the Long-term Recurrence of Appendiceal Goblet Cell Carcinoid. 61
32759580 2020
14
The Role of Adjuvant Chemotherapy in Non-Metastatic Goblet Cell Carcinoid of the Appendix: An 11-Year Experience from the National Cancer Database. 61
33231767 2020
15
Goblet Cell Carcinoid Tumors During Emergent General Surgery. 61
32841045 2020
16
Carcinoid tumours of the appendix: an analysis of emergency appendicectomies over a 24-year period and outcomes of laparoscopic versus open resection. 61
32274843 2020
17
Clinicopathological and Perioperative Outcome of Appendiceal Tumors: Case Review of 31 Patients. 61
33655185 2020
18
Erratum: Goblet cell carcinoid of the appendix: Two case reports and a review of the literature. 61
32714551 2020
19
Goblet Cell Carcinoid (GCC) of the Appendix presenting as a Small Bowel Obstruction. 61
32617127 2020
20
Goblet cell carcinoid of the rectum: a case report. 61
32683504 2020
21
Impact of Referral Center Pathology Review on Diagnosis and Management of Patients With Appendiceal Neoplasms. 61
31714810 2020
22
Perforated Goblet Cell Carcinoid of the Appendix. 61
32884510 2020
23
[Appendiceal Goblet Cell Carcinoid Successfully Treated with Bevacizumab plus mFOLFOX6 Regimen-A Case Report]. 61
32408332 2020
24
[A Case of Goblet Cell Carcinoid]. 61
32381880 2020
25
Survival Profile and Prognostic Factors for Appendiceal Mixed Neuroendocrine Non-neuroendocrine Neoplasms: A SEER Population-Based Study. 61
32903647 2020
26
Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature. 61
32155405 2020
27
A Case of Appendiceal Goblet Cell Carcinoid Tumor: Getting it right under the Microscope. 61
33442175 2020
28
Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix. 61
31592538 2019
29
[Two Cases of Goblet Cell Carcinoid of Appendix Treated with Oxaliplatin-Based Adjuvant Chemotherapy]. 61
32156949 2019
30
Goblet cell carcinoid of the appendix: Two case reports and a review of the literature. 61
31620280 2019
31
Epidemiology of and prognostic factors for appendiceal carcinomas: a retrospective, population-based study. 61
31642969 2019
32
Do get suspicious: diagnosing appendicular goblet cell carcinoid. 61
31760700 2019
33
Perianal Goblet Cell Carcinoid With Pagetoid Spread. 61
31079516 2019
34
Hypofractionated Stereotactic Radiation Therapy for Metastatic Adenocarcinoma ex Goblet Cell Carcinoid of the Appendix: Case Report and Literature Review. 61
31762753 2019
35
Tumor-to-tumor metastasis from appendiceal adenocarcinoma to an ovarian mature teratoma, mimicking malignant transformation of a teratoma: a case report. 61
31409389 2019
36
Assessment of appendix carcinoid tumors: A retrospective study. 61
31361229 2019
37
Knowledge gaps in the appendix: a multi-institutional study from seven academic centers. 61
30765881 2019
38
Neuroendocrine Markers Insulinoma-Associated Protein 1, Chromogranin, Synaptophysin, and CD56 Show Rare Positivity in Adenocarcinoma Ex-Goblet Cell Carcinoids. 61
31236152 2019
39
Appendiceal adenocarcinoma-Two unique cases of adenocarcinoma ex-goblet cell carcinoid. 61
30997090 2019
40
Goblet Cell Carcinoid/Carcinoma: An Update. 61
30601149 2019
41
ASO Author Reflections: Outcomes of Appendiceal Goblet Cell Carcinoid Tumors. 61
30465217 2018
42
Adenocarcinoma ex-goblet cell carcinoid of the ascending colon concurrent with conventional adenocarcinoma. 61
30314646 2018
43
Adenocarcinoma Ex-goblet Cell Carcinoid of the Appendix: a Case Report and Overview of the Disease. 61
28211016 2018
44
Ovarian Metastases of Breast Cancers With Signet Ring Cells: A Report of 17 Cases Including 14 Krukenberg Tumors. 61
29045292 2018
45
Perforation of appendiceal adenocarcinoma ex goblet cell carcinoid: a rare case. 61
30254732 2018
46
Goblet cell carcinoid of the appendix - diagnostic challenges and treatment updates: a case report and review of the literature. 61
30244681 2018
47
A Rare Case of Ampullary Goblet Cell Carcinoid. 61
29607953 2018
48
Outcomes of Surgical and Chemotherapeutic Treatments of Goblet Cell Carcinoid Tumors of the Appendix. 61
29916007 2018
49
Goblet cell carcinoid of the appendix. Review of the literature a propos of a rare case of endometrial metastases. 61
30358187 2018
50
Genomic profile of appendiceal goblet cell carcinoid is distinct compared to appendiceal neuroendocrine tumor and conventional adenocarcinoma. 61
29634977 2018
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Variations for Goblet Cell Carcinoid

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Expression for Goblet Cell Carcinoid

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Search GEO for disease gene expression data for Goblet Cell Carcinoid.
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Pathways for Goblet Cell Carcinoid

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Pathways related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
WNT Signaling 63
11.83 GAST CTNNB1 CDH1
2
Arf6 trafficking events 1
11.05 CTNNB1 CDH1
3
Stabilization and expansion of the E-cadherin adherens junction 1
10.97 CTNNB1 CDH1
4
Cell adhesion_Cadherin-mediated cell adhesion 23
10.92 CTNNB1 CDH1
5
E-cadherin signaling in the nascent adherens junction 1
10.67 CTNNB1 CDH1
6
Nectin adhesion pathway 1
10.35 CTNNB1 CDH1
7
RHO GTPases activate IQGAPs 65
9.74 CTNNB1 CDH1
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GO Terms for Goblet Cell Carcinoid

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Cellular components related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.16 CTNNB1 CDH1
2 apical junction complex GO:0043296 8.96 CTNNB1 CDH1
3 flotillin complex GO:0016600 8.62 CTNNB1 CDH1

Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adherens junction organization GO:0034332 9.16 CTNNB1 CDH1
2 entry of bacterium into host cell GO:0035635 8.96 CTNNB1 CDH1
3 cellular response to indole-3-methanol GO:0071681 8.62 CTNNB1 CDH1
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Sources for Goblet Cell Carcinoid

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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