GCC
MCID: GBL002
MIFTS: 40

Goblet Cell Carcinoid (GCC)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Goblet Cell Carcinoid

MalaCards integrated aliases for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 19 58 75
Goblet Cell Adenocarcinoid 19 58
Goblet Cell Carcinoma 19 58
Goblet Cell Tumor 19 58
Gcc 19 58
Carcinoid, Goblet Cell 71
Carcinoid Goblet Cell 53
Mucinous Carcinoid 19

Characteristics:


Age Of Onset:

Goblet Cell Carcinoma: Adult 58

Classifications:

Orphanet: 58  
Rare gastroenterological diseases
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 32 C18.1
UMLS via Orphanet 72 C0205695
Orphanet 58 ORPHA329984
UMLS 71 C0205695

Summaries for Goblet Cell Carcinoid

Orphanet: 58 Goblet cell carcinoma (GCC) is an aggressive type of endocrine tumor of the appendix (see this term) presenting equally in males and females in the fifth decade of life and manifesting with a palpable mass and abdominal pain or acute appendicitis. Metastasis to the ovaries, peritoneum or right colon has usually already occurred in half of patients at the time of diagnosis.

MalaCards based summary: Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to carcinoid tumors, intestinal and carcinoid syndrome. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways/superpathways are Regulation of nuclear beta catenin signaling and target gene transcription and Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met). Affiliated tissues include appendix, colon and ovary.

GARD: 19 Goblet cell carcinoid (GCC) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. People with this tumor may develop acute appendicitis, abdominal pain, and diarrhea.

Wikipedia: 75 The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a... more...

Related Diseases for Goblet Cell Carcinoid

Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 carcinoid tumors, intestinal 31.8 ENO2 CHGA
2 carcinoid syndrome 31.4 ENO2 CHGA
3 appendix adenocarcinoma 30.9 KRT20 CHGA
4 diffuse gastric cancer 30.6 CTNNB1 CDH1
5 adenocarcinoma 30.4 KRT20 CTNNB1 CHGA CDH1
6 mucinous adenocarcinoma 30.4 KRT20 CTNNB1
7 cystadenoma 30.2 KRT20 CHGA
8 neuroendocrine tumor 30.1 KRT20 ENO2 CHGA CDH1
9 signet ring cell adenocarcinoma 29.9 KRT20 CTNNB1 CHGA CDH1
10 mucinous cystadenocarcinoma 29.8 KRT20 CEACAM7
11 pseudomyxoma peritonei 29.8 KRT20 CTNNB1 CDH1
12 colorectal adenocarcinoma 29.8 KRT20 CTNNB1 CDH1
13 rectum adenocarcinoma 29.6 KRT20 CTNNB1
14 thyroid gland follicular carcinoma 29.6 CTNNB1 CDH1
15 colonic benign neoplasm 29.6 KRT20 CTNNB1 CDH1
16 cystic teratoma 29.6 KRT20 ENO2 CHGA
17 benign teratoma 29.6 KRT20 ENO2 CHGA
18 mixed cell type cancer 29.5 ENO2 CTNNB1 CHGA CDH1
19 colon adenocarcinoma 29.4 KRT20 CTNNB1 CEACAM7 CDH1
20 papillary carcinoma 29.3 KRT20 CHGA CDH1
21 adenoma 29.3 KRT20 CDH1 CTNNB1 CHGA
22 neuroendocrine carcinoma 29.2 KRT20 ENO2 CHGA CDH1
23 bladder urothelial carcinoma 29.2 KRT20 CTNNB1 CDH1
24 teratoma 28.9 KRT20 ENO2 CTNNB1 CHGA CDH1
25 glassy cell carcinoma of the cervix 11.0
26 glaucomatocyclitic crisis 11.0
27 neuroendocrine neoplasm of appendix 11.0
28 appendicitis 10.8
29 rare tumor 10.6
30 appendiceal neoplasm 10.5
31 leiomyoma, uterine 10.2
32 neurofibromatosis, type i 10.2
33 neurofibromatosis-noonan syndrome 10.2
34 schistosomiasis 10.2
35 peritonitis 10.2
36 ileus 10.2
37 neurofibromatosis 10.2
38 sclerosing hemangioma 10.1 CTNNB1 CHGA
39 fragile x syndrome 10.1
40 intellectual developmental disorder, x-linked 109 10.1
41 beta-thalassemia 10.1
42 thalassemia 10.1
43 blastoma 10.1 ENO2 CHGA
44 ganglioneuroma 10.1 ENO2 CHGA
45 vaginal glandular tumor 10.1 ENO2 CHGA
46 cerebral neuroblastoma 10.1 ENO2 CHGA
47 thymus small cell carcinoma 10.1 ENO2 CHGA
48 gastric small cell carcinoma 10.1 ENO2 CHGA
49 breast neuroendocrine neoplasm 10.1 ENO2 CHGA
50 acinar cell carcinoma 10.1 CTNNB1 CHGA

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to Goblet Cell Carcinoid

Symptoms & Phenotypes for Goblet Cell Carcinoid

Drugs & Therapeutics for Goblet Cell Carcinoid

Search Clinical Trials, NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

Anatomical Context for Goblet Cell Carcinoid

Organs/tissues related to Goblet Cell Carcinoid:

MalaCards : Appendix, Colon, Ovary, Lymph Node, Lung, Breast, Liver

Publications for Goblet Cell Carcinoid

Articles related to Goblet Cell Carcinoid:

(show top 50) (show all 288)
# Title Authors PMID Year
1
Goblet cell carcinoid of the appendix: a specific type of carcinoma. 53 62
18042066 2007
2
Composite glandular-endocrine cell carcinoma of the stomach. Report of two cases with goblet cell carcinoid component. 53 62
15792127 2005
3
Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin. 53 62
11350611 2001
4
Goblet Cell Carcinoma of the Appendix with Synchronous Adenocarcinoma of the Cecum: Distinct or Related Entities? 62
36278575 2022
5
Clinicopathological features of appendiceal goblet cell adenocarcinoma in Japan: a multicenter retrospective study. 62
35913635 2022
6
Incidental discovery of goblet cell carcinoid, a rare appendiceal malignancy case report. 62
35919700 2022
7
Goblet cell adenocarcinoma of the appendix: an update and practical approach to diagnosis and grading. 62
35691370 2022
8
An International Registry of Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. 62
35286418 2022
9
Primary ovarian mucinous carcinoid arising in a mature cystic teratoma-A rare entity. 62
35074992 2022
10
[Clinicopathological analysis and surgical strategy of primary appendiceal neoplasms]. 62
34923789 2021
11
[A Case Report of an Appendiceal Goblet Cell Carcinoid]. 62
35046262 2021
12
The new WHO classification of gastrointestinal neuroendocrine tumors and immunohistochemical expression of somatostatin receptor 2 and 5. 62
34475969 2021
13
An extremely rare finding of goblet cell carcinoid of the appendix. A case report. 62
34636340 2021
14
Goblet cell carcinoma of appendix detected during surgery for ovarian tumors. 62
34504701 2021
15
[Pathological diagnosis and clinical significance of appendiceal epithelial neoplasms]. 62
34530571 2021
16
Frequency and Risk Factors for Metastasis in Newly Diagnosed Appendiceal Carcinoma. 62
34395124 2021
17
Chemotherapy in the treatment of different histological types of appendiceal cancers: a SEER based study. 62
34225672 2021
18
ASO Author Reflections: Impact of Adjuvant Chemotherapy After Right Hemicolectomy for Appendiceal Goblet Cell Carcinoid. 62
33389287 2021
19
The Role of Adjuvant Chemotherapy in Non-Metastatic Goblet Cell Carcinoid of the Appendix: An 11-Year Experience from the National Cancer Database. 62
33231767 2021
20
Goblet Cell Carcinoma-a Rare Tumour with Unusual Presentation. 62
32789764 2021
21
The 2019 World Health Organization Classification of appendiceal, colorectal and anal canal tumours: an update and critical assessment. 62
33461799 2021
22
Histologic and Racial/Ethnic Patterns of Appendiceal Cancer among Young Patients. 62
33795212 2021
23
Comparative study of mucinous and non-mucinous appendiceal neoplasms with peritoneal dissemination treated by cyoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). 62
33280949 2021
24
New insights in the pathology of peritoneal surface malignancy. 62
33968439 2021
25
Is adjuvant chemotherapy beneficial for stage II-III goblet cell carcinoid/goblet cell adenocarcinoma of the appendix? 62
33360118 2021
26
Appendiceal Goblet Cell Adenocarcinoma Case Report and Review of the Literature. 62
33786220 2021
27
Why did they change that? Practical implications of the evolving classification of neuroendocrine tumours of the gastrointestinal tract. 62
33382490 2021
28
Advanced appendiceal goblet cell carcinoids with intestinal obstruction: two case reports. 62
32989687 2020
29
Triple Synchronous Tumors of the Appendix: Carcinoid, Goblet Cell Carcinoma and Low-Grade Mucinous Neoplasm. 62
33345570 2020
30
[More than Four-Year Survival of Appendiceal Adenocarcinoma Due to Goblet Cell Carcinoid and Manifesting as an Abdominal Tumor and Hydronephrosis]. 62
33468946 2020
31
Molecular Characterization of Appendiceal Goblet Cell Carcinoid. 62
33037134 2020
32
Duodenal Obstruction Caused by the Long-term Recurrence of Appendiceal Goblet Cell Carcinoid. 62
32759580 2020
33
Goblet Cell Carcinoid Tumors During Emergent General Surgery. 62
32841045 2020
34
Carcinoid tumours of the appendix: an analysis of emergency appendicectomies over a 24-year period and outcomes of laparoscopic versus open resection. 62
32274843 2020
35
Clinicopathological and Perioperative Outcome of Appendiceal Tumors: Case Review of 31 Patients. 62
33655185 2020
36
Gastric goblet cell carcinoma concurrent with a neuroendocrine tumor. 62
32825959 2020
37
Erratum: Goblet cell carcinoid of the appendix: Two case reports and a review of the literature. 62
32714551 2020
38
Goblet Cell Carcinoid (GCC) of the Appendix presenting as a Small Bowel Obstruction. 62
32617127 2020
39
Goblet cell carcinoid of the rectum: a case report. 62
32683504 2020
40
Appendiceal cancer : a review of the literature. 62
33094592 2020
41
Impact of Referral Center Pathology Review on Diagnosis and Management of Patients With Appendiceal Neoplasms. 62
31714810 2020
42
[Appendiceal Goblet Cell Carcinoid Successfully Treated with Bevacizumab plus mFOLFOX6 Regimen-A Case Report]. 62
32408332 2020
43
Perforated Goblet Cell Carcinoid of the Appendix. 62
32884510 2020
44
A goblet cell carcinoma of the appendix presenting as an acute appendicitis: a case report. 62
30081726 2020
45
Outcomes After Adjuvant Hyperthermic Intraperitoneal Chemotherapy for High-Risk Primary Appendiceal Neoplasms After Complete Resection. 62
31368017 2020
46
Outcomes in Peritoneal Carcinomatosis from Appendiceal Goblet Cell Carcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC). 62
31646450 2020
47
Survival Profile and Prognostic Factors for Appendiceal Mixed Neuroendocrine Non-neuroendocrine Neoplasms: A SEER Population-Based Study. 62
32903647 2020
48
A Case of Appendiceal Goblet Cell Carcinoid Tumor: Getting it right under the Microscope. 62
33442175 2020
49
[A Case of Goblet Cell Carcinoid]. 62
32381880 2020
50
Colonic Goblet Cell Carcinoid: Rarity of a Rarity! A Case Report and Review of Literature. 62
32155405 2020

Variations for Goblet Cell Carcinoid

Cosmic variations for Goblet Cell Carcinoid:

8 (show top 50) (show all 239)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM142841902 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
2 COSM122736483 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2A>G p.? 17:7675217-7675217 4
3 COSM121879352 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2A>G p.? 17:7675217-7675217 4
4 COSM106059013 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
5 COSM143373513 TP53 ovary,NS,carcinoma,adenocarcinoma c.278A>G p.K93R 17:7675217-7675217 4
6 COSM111764887 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
7 COSM106053540 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 4
8 COSM122277330 TP53 ovary,NS,carcinoma,adenocarcinoma c.80C>T p.A27V 17:7675136-7675136 4
9 COSM142839188 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
10 COSM111758977 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 4
11 COSM121883809 TP53 ovary,NS,carcinoma,adenocarcinoma c.146G>A p.R49H 17:7675070-7675070 4
12 COSM105627180 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 4
13 COSM145023722 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 4
14 COSM93186307 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
15 COSM122734810 TP53 ovary,NS,carcinoma,adenocarcinoma c.182A>T p.H61L 17:7674953-7674953 4
16 COSM142837646 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 4
17 COSM143376903 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 4
18 COSM143944663 TP53 ovary,NS,carcinoma,adenocarcinoma c.101A>T p.H34L 17:7674953-7674953 4
19 COSM142565939 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 4
20 COSM142560671 TP53 ovary,NS,carcinoma,adenocarcinoma c.799C>T p.R267* 17:7673704-7673704 4
21 COSM105623043 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
22 COSM144013781 TP53 ovary,NS,carcinoma,adenocarcinoma c.883C>T p.R295* 17:7673704-7673704 4
23 COSM87898818 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 4
24 COSM105626845 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
25 COSM143162071 TP53 ovary,NS,carcinoma,adenocarcinoma c.65G>A p.R22H 17:7675070-7675070 4
26 COSM143159037 TP53 ovary,NS,carcinoma,adenocarcinoma c.-83A>G p.? 17:7675217-7675217 4
27 COSM144651539 TP53 ovary,NS,carcinoma,adenocarcinoma c.799C>T p.R267* 17:7673704-7673704 4
28 COSM122734486 TP53 ovary,NS,carcinoma,adenocarcinoma c.520C>T p.R174* 17:7673704-7673704 4
29 COSM121876629 TP53 ovary,NS,carcinoma,adenocarcinoma c.520C>T p.R174* 17:7673704-7673704 4
30 COSM122274028 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2A>G p.? 17:7675217-7675217 4
31 COSM122277714 TP53 ovary,NS,carcinoma,adenocarcinoma c.146G>A p.R49H 17:7675070-7675070 4
32 COSM106055648 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
33 COSM112253979 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 4
34 COSM144657786 TP53 ovary,NS,carcinoma,adenocarcinoma c.359C>T p.A120V 17:7675136-7675136 4
35 COSM142562472 TP53 ovary,NS,carcinoma,adenocarcinoma c.278A>G p.K93R 17:7675217-7675217 4
36 COSM87905366 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
37 COSM142842181 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 4
38 COSM144310924 TP53 ovary,NS,carcinoma,adenocarcinoma c.461A>T p.H154L 17:7674953-7674953 4
39 COSM143377232 TP53 ovary,NS,carcinoma,adenocarcinoma c.425G>A p.R142H 17:7675070-7675070 4
40 COSM143161752 TP53 ovary,NS,carcinoma,adenocarcinoma c.-2C>T p.? 17:7675136-7675136 4
41 COSM142561000 TP53 ovary,NS,carcinoma,adenocarcinoma c.461A>T p.H154L 17:7674953-7674953 4
42 COSM93184525 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 4
43 COSM93189598 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
44 COSM105620760 TP53 ovary,NS,carcinoma,adenocarcinoma c.782+477C>T p.? 17:7673704-7673704 4
45 COSM143944264 TP53 ovary,NS,carcinoma,adenocarcinoma c.439C>T p.R147* 17:7673704-7673704 4
46 COSM112255786 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
47 COSM122272447 TP53 ovary,NS,carcinoma,adenocarcinoma c.182A>T p.H61L 17:7674953-7674953 4
48 COSM87901171 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
49 COSM122271907 TP53 ovary,NS,carcinoma,adenocarcinoma c.520C>T p.R174* 17:7673704-7673704 4
50 COSM143371251 TP53 ovary,NS,carcinoma,adenocarcinoma c.799C>T p.R267* 17:7673704-7673704 4

Expression for Goblet Cell Carcinoid

Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for Goblet Cell Carcinoid

GO Terms for Goblet Cell Carcinoid

Cellular components related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catenin complex GO:0016342 9.46 CTNNB1 CDH1
2 apical junction complex GO:0043296 9.13 CDH1 CTNNB1
3 flotillin complex GO:0016600 8.92 CTNNB1 CDH1

Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adherens junction organization GO:0034332 9.33 CTNNB1 CDH1
2 cellular response to indole-3-methanol GO:0071681 9.26 CTNNB1 CDH1
3 negative regulation of neuron death GO:1901215 9.02 ENO2 CTNNB1 CHGA

Sources for Goblet Cell Carcinoid

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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