MCID: GBL002
MIFTS: 37

Goblet Cell Carcinoid

Categories: Rare diseases, Gastrointestinal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Goblet Cell Carcinoid

MalaCards integrated aliases for Goblet Cell Carcinoid:

Name: Goblet Cell Carcinoid 53 59
Goblet Cell Adenocarcinoid 53 59
Goblet Cell Carcinoma 53 59
Goblet Cell Tumor 53 59
Gcc 53 59
Carcinoid, Goblet Cell 73
Carcinoid Goblet Cell 55
Mucinous Carcinoid 53

Characteristics:

Orphanet epidemiological data:

59
goblet cell carcinoma
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

Orphanet 59 ORPHA329984
UMLS via Orphanet 74 C0205695
ICD10 via Orphanet 34 C18.1
UMLS 73 C0205695

Summaries for Goblet Cell Carcinoid

NIH Rare Diseases : 53 Goblet cell carcinoid (GCC) is a rare tumor normally occurring in the appendix which displays features of both a neuroendocrine tumor and a more aggressive form of cancer known as an adenocarcinoma. It is usually diagnosed in people over the age of 50. People with this tumor may develop acute appendicitis, abdominal pain, and diarrhea. Prognosis largely depends on the size of the tumor and whether it has spread to other parts of the body. Treatment involves surgery to remove the tumor. Depending on how much the tumor has spread, surgeons may remove the appendix, part of the colon, or the ovaries (in women). Some people will have chemotherapy after surgery.

MalaCards based summary : Goblet Cell Carcinoid, also known as goblet cell adenocarcinoid, is related to carcinoid syndrome and cystadenoma. An important gene associated with Goblet Cell Carcinoid is CDH1 (Cadherin 1), and among its related pathways/superpathways are Cell cycle Cell cycle (generic schema) and Arf6 trafficking events. Affiliated tissues include appendix, ovary and colon.

Wikipedia : 76 The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine... more...

Related Diseases for Goblet Cell Carcinoid

Diseases related to Goblet Cell Carcinoid via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 carcinoid syndrome 31.4 CHGA ENO2
2 cystadenoma 30.9 CHGA KRT20
3 carcinoid tumors, intestinal 30.5 CHGA ENO2
4 neuroendocrine tumor 28.7 CHGA ENO2 GAST KRT20
5 glassy cell carcinoma of the cervix 10.9
6 vaginal benign neoplasm 10.7 CHGA KRT20
7 ovarian large-cell neuroendocrine carcinoma 10.7 CHGA KRT20
8 vaginal adenoma 10.7 CHGA KRT20
9 vaginal tubulovillous adenoma 10.7 CHGA KRT20
10 adenoma of the pancreas 10.7 CHGA KRT20
11 linitis plastica 10.6 CDH1 KRT20
12 adenoid squamous cell carcinoma 10.6 CDH1 KRT20
13 morpheaform basal cell carcinoma 10.6 CDH1 KRT20
14 gastric diffuse adenocarcinoma 10.6 CDH1 KRT20
15 dermoid cyst 10.6 CHGA KRT20
16 infiltrative basal cell carcinoma 10.5 CDH1 KRT20
17 ureter small cell carcinoma 10.5 CHGA ENO2
18 urinary bladder small cell neuroendocrine carcinoma 10.5 CHGA ENO2
19 intracranial primitive neuroectodermal tumor 10.5 CHGA ENO2
20 auditory system cancer 10.5 CHGA ENO2
21 cecum adenocarcinoma 10.5 CHGA KRT20
22 gallbladder small cell carcinoma 10.5 CHGA ENO2
23 epithelioid malignant peripheral nerve sheath tumor 10.5 CHGA ENO2
24 pulmonary large cell neuroendocrine carcinoma 10.5 CHGA ENO2
25 atypical follicular adenoma 10.5 CHGA ENO2
26 olfactory nerve neoplasm 10.5 CHGA ENO2
27 cauda equina neoplasm 10.5 CHGA ENO2
28 acute thyroiditis 10.5 CHGA ENO2
29 nodular ganglioneuroblastoma 10.5 CHGA ENO2
30 pulmonary sclerosing hemangioma 10.5 CHGA CTNNB1
31 pineocytoma 10.5 CHGA ENO2
32 respiratory system benign neoplasm 10.5 CHGA ENO2
33 extrahepatic bile duct adenocarcinoma 10.5 CDH1 ENO2
34 gastric squamous cell carcinoma 10.5 CHGA ENO2
35 gastric small cell carcinoma 10.5 CHGA ENO2
36 subependymoma 10.5 CHGA ENO2
37 somatostatinoma 10.5 CHGA ENO2
38 papillary ependymoma 10.5 CHGA ENO2
39 adenocarcinoma 10.5
40 mature teratoma of the ovary 10.4 ENO2 KRT20
41 central neurocytoma 10.4 CHGA ENO2
42 cutaneous ganglioneuroma 10.4 ENO2 KRT20
43 microcystic meningioma 10.4 CDH1 ENO2
44 lung acinar adenocarcinoma 10.4 CTNNB1 KRT20
45 breast adenomyoepithelioma 10.4 CDH1 ENO2
46 spinal meningioma 10.4 CHGA ENO2
47 breast myoepithelial neoplasm 10.4 CDH1 ENO2
48 spinal canal and spinal cord meningioma 10.4 CHGA ENO2
49 cranial nerve malignant neoplasm 10.4 CHGA ENO2
50 lobular neoplasia 10.4 CDH1 CTNNB1

Graphical network of the top 20 diseases related to Goblet Cell Carcinoid:



Diseases related to Goblet Cell Carcinoid

Symptoms & Phenotypes for Goblet Cell Carcinoid

Drugs & Therapeutics for Goblet Cell Carcinoid

Search Clinical Trials , NIH Clinical Center for Goblet Cell Carcinoid

Genetic Tests for Goblet Cell Carcinoid

Anatomical Context for Goblet Cell Carcinoid

MalaCards organs/tissues related to Goblet Cell Carcinoid:

41
Appendix, Ovary, Colon, Lung, Lymph Node

Publications for Goblet Cell Carcinoid

Articles related to Goblet Cell Carcinoid:

(show top 50) (show all 95)
# Title Authors Year
1
Goblet cell carcinoid of the appendix: Case report of a high grade tumor in a 20-year-old. ( 29698881 )
2018
2
Endoscopic diagnosis of a goblet cell carcinoid tumour of the appendix. ( 29764845 )
2018
3
Goblet cell carcinoid of the appendix - An interobserver variability study using two proposed classification systems. ( 29414399 )
2018
4
A Rare Case of Ampullary Goblet Cell Carcinoid. ( 29607953 )
2018
5
Genomic profile of appendiceal goblet cell carcinoid is distinct compared to appendiceal neuroendocrine tumor and conventional adenocarcinoma. ( 29634977 )
2018
6
Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. ( 29327707 )
2018
7
Outcomes of Surgical and Chemotherapeutic Treatments of Goblet Cell Carcinoid Tumors of the Appendix. ( 29916007 )
2018
8
Appendiceal goblet cell carcinoid: common errors in staging and clinical interpretation with a proposal for an improved terminology. ( 28551326 )
2017
9
A Study of Appendiceal Crypt Cell Adenocarcinoma (So-Called Goblet Cell Carcinoid and Its Related Adenocarcinoma). ( 28823572 )
2017
10
Adenocarcinoma Ex-Goblet Cell Carcinoid of the Appendix With Metastatic Peritoneal Spread to Meckel's Diverticulum and Endometriosis. ( 28449607 )
2017
11
Intestinal goblet cell carcinoid presenting with recurrent sterile peritonitis in a patient on peritoneal dialysis: a case report. ( 28193185 )
2017
12
Amyand's hernia containing an appendiceal goblet cell carcinoid tumour. ( 28302663 )
2017
13
Adenocarcinoma Ex-goblet Cell Carcinoid of the Appendix: a Case Report and Overview of the Disease. ( 28211016 )
2017
14
Goblet cell carcinoid of the appendix and mixed adenoneuroendocrine carcinoma: Report of three cases. ( 28808504 )
2017
15
Adenocarcinoma Ex Goblet Cell Carcinoid of Appendix: Two Case Reports. ( 28890838 )
2017
16
Synchronous sessile serrated adenoma and goblet cell carcinoid in the appendix: A case report and literature review. ( 27773125 )
2016
17
Adenocarcinoma ex-goblet cell carcinoid (appendiceal-type crypt cell adenocarcinoma) is a morphologically distinct entity with highly aggressive behavior and frequent association with peritoneal/intra-abdominal dissemination: an analysis of 77 cases. ( 27338636 )
2016
18
Goblet Cell Carcinoid of the Rectum in a Patient with Neurofibromatosis Type 1. ( 27237132 )
2016
19
Goblet-cell carcinoid of the ovary: A case report with ultrastructural analysis. ( 27922277 )
2016
20
Simplified 2-tier histologic grading system accurately predicts outcomes in goblet cell carcinoid of the appendix. ( 26433702 )
2015
21
Peritoneal metastatic goblet-cell carcinoid tumor treated with cytoreductive surgery and intraperitoneal chemotherapy. ( 25960976 )
2015
22
Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. ( 26030247 )
2015
23
A rare combination of ovarian and uterine leiomyomas with goblet cell carcinoid of the appendix. ( 25685587 )
2015
24
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix. ( 24560515 )
2014
25
Incidentally discovered goblet cell carcinoid clinically presenting as acute intestinal obstruction: a case report with review of literature. ( 24739849 )
2014
26
Goblet cells carcinoid with mucinous adenocarcinoma of the vermiform appendix: a step towards the unitary intestinal stem cell theory? ( 24943968 )
2014
27
Late recurrence and metastasis of an appendiceal goblet cell carcinoid 24 years after appendectomy. ( 24451973 )
2014
28
Goblet cell carcinoid neoplasm of the appendix: clinical and CT features. ( 23088880 )
2013
29
Appendiceal goblet cell carcinoid and mucinous neoplasms are closely associated tumors: Lessons from their coexistence in primary tumors and concurrence in peritoneal dissemination. ( 24374723 )
2013
30
Goblet cell carcinoid tumor of the appendix. ( 24224299 )
2013
31
Goblet cell carcinoid in ascitic fluid. ( 22550034 )
2013
32
Goblet cell carcinoid of appendix: A rare case with literature review. ( 23416502 )
2013
33
Survival rates for goblet cell carcinoma of the appendix. ( 24135761 )
2013
34
Adenocarcinoma ex goblet cell carcinoid in a renal transplant patient: a case report and review of the literature. ( 23564828 )
2013
35
Metastatic appendiceal goblet cell carcinoid masquerading as mucinous adenocarcinoma in effusion cytology: A diagnostic pitfall. ( 23833405 )
2013
36
Goblet cell carcinoid and mucinous cystadenoma in an interval appendectomy specimen. ( 22273311 )
2012
37
Goblet cell carcinoid in a patient with neurofibromatosis type 1: a rare combination. ( 23304574 )
2012
38
Appendiceal goblet cell carcinoid tumour: a case of unexpected lung metastasis. ( 22933998 )
2012
39
Schistosomiasis may contribute to goblet cell carcinoid of the appendix. ( 22746391 )
2012
40
Serotonin- and somatostatin-positive goblet cell carcinoid of the duodenum. ( 22918208 )
2012
41
Goblet cell carcinoid of the vermiform appendix - a case report. ( 23359204 )
2012
42
Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. ( 20640606 )
2011
43
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. ( 22107115 )
2011
44
Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). ( 21753706 )
2011
45
Schistosomiasis may contribute to Goblet Cell Carcinoid of the Appendix. ( 22176273 )
2011
46
Goblet cell carcinoid of the rectum with lymph node metastasis: report of a case. ( 21874432 )
2011
47
The role of Ki-67 in predicting biological behavior of goblet cell carcinoid tumor in appendix. ( 21824598 )
2011
48
Goblet cell carcinoid tumor: a rare cause of appendicitis. ( 21396295 )
2011
49
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china. ( 20732910 )
2010
50
Lipid-rich and clear cell neuroendocrine tumors ("carcinoids") of the appendix: potential confusion with goblet cell carcinoid. ( 20139759 )
2010

Variations for Goblet Cell Carcinoid

Cosmic variations for Goblet Cell Carcinoid:

9
(show top 50) (show all 406)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6938356 ZFHX3 large intestine,appendix,carcinoma,adenocarcinoma c.3122A>C p.K1041T 16:72950563-72950563 4
2 COSM6933903 XIAP large intestine,appendix,carcinoma,adenocarcinoma c.591A>T p.Q197H 23:123886253-123886253 4
3 COSM6976113 WT1 large intestine,appendix,carcinoma,adenocarcinoma c.463G>A p.D155N 11:32428599-32428599 4
4 COSM10663 TP53 ovary,NS,carcinoma,adenocarcinoma c.916C>T p.R306* 17:7673704-7673704 4
5 COSM11066 TP53 ovary,NS,carcinoma,adenocarcinoma c.578A>T p.H193L 17:7674953-7674953 4
6 COSM10738 TP53 ovary,NS,carcinoma,adenocarcinoma c.542G>A p.R181H 17:7675070-7675070 4
7 COSM11148 TP53 ovary,NS,carcinoma,adenocarcinoma c.476C>T p.A159V 17:7675136-7675136 4
8 COSM11582 TP53 ovary,NS,carcinoma,adenocarcinoma c.395A>G p.K132R 17:7675217-7675217 4
9 COSM10648 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.524G>A p.R175H 17:7675088-7675088 4
10 COSM11183 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.799C>T p.R267W 17:7673821-7673821 4
11 COSM44944 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.451C>G p.P151A 17:7675161-7675161 4
12 COSM10883 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.731G>A p.G244D 17:7674232-7674232 4
13 COSM10704 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.844C>T p.R282W 17:7673776-7673776 4
14 COSM10645 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.527G>T p.C176F 17:7675085-7675085 4
15 COSM10808 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.488A>G p.Y163C 17:7675124-7675124 4
16 COSM11286 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.1015G>T p.E339* 17:7670694-7670694 4
17 COSM10863 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.833C>T p.P278L 17:7673787-7673787 4
18 COSM11073 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.1024C>T p.R342* 17:7670685-7670685 4
19 COSM10659 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.817C>T p.R273C 17:7673803-7673803 4
20 COSM43955 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.514G>A p.V172I 17:7675098-7675098 4
21 COSM10662 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.743G>A p.R248Q 17:7674220-7674220 4
22 COSM10794 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.796G>A p.G266R 17:7673824-7673824 4
23 COSM12193 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.668C>T p.P223L 17:7674863-7674863 4
24 COSM44093 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.644G>A p.S215N 17:7674887-7674887 4
25 COSM43872 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.560-1G>C p.? 17:7674972-7674972 4
26 COSM6901 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.559+1G>A p.? 17:7675052-7675052 4
27 COSM44388 TP53 large intestine,appendix,carcinoma,adenocarcinoma c.853G>T p.E285* 17:7673767-7673767 4
28 COSM6954252 TOP1 large intestine,appendix,carcinoma,adenocarcinoma c.1303A>G p.I435V 20:41101348-41101348 4
29 COSM6904336 TNFAIP3 ovary,NS,carcinoma,adenocarcinoma c.940G>A p.V314I 6:137877210-137877210 4
30 COSM2983542 TGFBR2 large intestine,appendix,carcinoma,adenocarcinoma c.1582C>G p.R528G 3:30691477-30691477 4
31 COSM33076 TGFBR2 large intestine,appendix,carcinoma,adenocarcinoma c.1583G>A p.R528H 3:30691478-30691478 4
32 COSM6938933 TGFBR2 large intestine,appendix,carcinoma,adenocarcinoma c.1069G>T p.G357W 3:30672252-30672252 4
33 COSM6503127 TGFBR2 large intestine,appendix,carcinoma,adenocarcinoma c.155A>C p.K52T 3:30644807-30644807 4
34 COSM6967188 TCF7L2 large intestine,appendix,carcinoma,adenocarcinoma c.1760C>T p.P587L 10:113165941-113165941 4
35 COSM6083762 STK11 large intestine,appendix,carcinoma,adenocarcinoma c.752G>T p.G251V 19:1221230-1221230 4
36 COSM6932862 STAT3 large intestine,appendix,carcinoma,adenocarcinoma c.365C>T p.A122V 17:42345566-42345566 4
37 COSM6938938 SPOP large intestine,appendix,carcinoma,adenocarcinoma c.413G>A p.R138H 17:49619048-49619048 4
38 COSM4067486 SPOP large intestine,appendix,carcinoma,adenocarcinoma c.295C>T p.R99W 17:49619291-49619291 4
39 COSM6982254 SOX9 large intestine,appendix,carcinoma,adenocarcinoma c.613A>T p.K205* 17:72122900-72122900 4
40 COSM2719086 SOX17 large intestine,appendix,carcinoma,adenocarcinoma c.329C>T p.T110M 8:54459079-54459079 4
41 COSM4596765 SMARCB1 large intestine,appendix,carcinoma,adenocarcinoma c.1130G>T p.R377L 22:23834152-23834152 4
42 COSM3724529 SMARCA4 large intestine,appendix,carcinoma,adenocarcinoma c.2438+1G>A p.? 19:11013113-11013113 4
43 COSM14135 SMAD4 ovary,NS,carcinoma,adenocarcinoma c.1051G>C p.D351H 18:51065518-51065518 4
44 COSM6983349 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1528G>T p.G510* 18:51078336-51078336 4
45 COSM14151 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1081C>A p.R361S 18:51065548-51065548 4
46 COSM14096 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1333C>T p.R445* 18:51076662-51076662 4
47 COSM14134 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1576G>T p.E526* 18:51078384-51078384 4
48 COSM14122 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1082G>A p.R361H 18:51065549-51065549 4
49 COSM6963798 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1607T>C p.L536P 18:51078415-51078415 4
50 COSM14050 SMAD4 large intestine,appendix,carcinoma,adenocarcinoma c.1516G>A p.V506M 18:51078324-51078324 4

Expression for Goblet Cell Carcinoid

Search GEO for disease gene expression data for Goblet Cell Carcinoid.

Pathways for Goblet Cell Carcinoid

GO Terms for Goblet Cell Carcinoid

Cellular components related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.26 CDH1 CTNNB1
2 catenin complex GO:0016342 9.16 CDH1 CTNNB1
3 apical junction complex GO:0043296 8.96 CDH1 CTNNB1
4 flotillin complex GO:0016600 8.62 CDH1 CTNNB1

Biological processes related to Goblet Cell Carcinoid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron death GO:1901215 9.26 CHGA CTNNB1
2 adherens junction organization GO:0034332 9.16 CDH1 CTNNB1
3 entry of bacterium into host cell GO:0035635 8.96 CDH1 CTNNB1
4 cellular response to indole-3-methanol GO:0071681 8.62 CDH1 CTNNB1

Sources for Goblet Cell Carcinoid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....