Aliases & Classifications for Goiter

MalaCards integrated aliases for Goiter:

Name: Goiter 12 29 55 44 15 73
Goitre 12 76 15

Classifications:



External Ids:

Disease Ontology 12 DOID:12176
ICD10 33 E04.9
ICD9CM 35 240.9
MeSH 44 D006042
NCIt 50 C26785
SNOMED-CT 68 3716002
UMLS 73 C0018021

Summaries for Goiter

Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and endemic goiter. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Remifentanil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related phenotypes are Decreased HPV16-GFP infection and endocrine/exocrine gland

Wikipedia : 76 A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre is... more...

Related Diseases for Goiter

Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 34.2 DICER1 TG TPO
2 endemic goiter 33.5 SERPINA7 TG TPO TSHR
3 pendred syndrome 33.3 PAX8 SLC26A4 TG TPO
4 plummer's disease 33.3 TG THRB TPO
5 toxic diffuse goiter 33.2 SERPINA7 TG TPO TRH TSHR
6 nodular goiter 33.2 CALCA LGALS3 SLC5A5 TG TPO TSHR
7 dyshormonogenic goiter 33.1 DUOXA2 SERPINA7 SLC26A4 TG
8 nontoxic goiter 33.0 BGLAP CALCA SERPINA7 TG TPO TSHR
9 graves' disease 32.8 GNAS SERPINA7 TG THRB TPO TSHR
10 multinodular goiter 32.8 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
11 familial thyroid dyshormonogenesis 32.6 DUOXA2 IYD SLC5A5 TG TPO
12 hashimoto thyroiditis 31.8 CALCA LGALS3 SLC26A4 TG TPO TSHR
13 anaplastic thyroid cancer 31.8 NKX2-1 PAX8 TG TPO
14 hyperthyroidism 31.4 BGLAP GNAS SERPINA7 TG THRB TPO
15 thyroid hormone resistance, generalized, autosomal dominant 30.9 SERPINA7 TG THRB TRH TXNRD2
16 myxedema 30.6 TG TPO TSHR
17 hypothyroidism, congenital, nongoitrous, 2 30.5 LGALS3 NKX2-1 PAX8 SERPINA7 SLC26A4 TG
18 hypothyroidism, congenital, nongoitrous, 1 30.3 GNAS TSHR
19 hypothyroidism 30.3 CALCA DUOXA2 GNAS IYD NKX2-1 PAX8
20 suppurative thyroiditis 30.2 CALCA TG
21 thyroid carcinoma, familial medullary 30.1 CALCA NKX2-1 TG
22 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 30.1 TG TPO
23 neonatal hypothyroidism 30.0 PAX8 SLC5A5 TG TPO TSHR
24 hypothyroidism, congenital, nongoitrous, 4 30.0 SERPINA7 TG TPO TRH
25 subacute thyroiditis 29.9 SERPINA7 TG TPO TSHR
26 papillary thyroid microcarcinoma 29.8 CALCA NKX2-1 TG TSHR
27 ovarian germ cell teratoma 29.8 NKX2-1 TG
28 struma ovarii 29.7 NKX2-1 TG TSHR
29 thyroid crisis 29.7 SERPINA7 TG THRB
30 thyroiditis 29.7 CALCA SERPINA7 TG THRB TPO TRH
31 fibrous dysplasia 29.6 BGLAP CALCA GNAS
32 athyreosis 29.5 NKX2-1 PAX8 SLC26A4 TG TSHR
33 hyperthyroxinemia 29.5 SERPINA7 TPO TRH TSHR
34 generalized resistance to thyroid hormone 29.5 THRB TRH TXNRD2
35 papillary carcinoma 29.4 CALCA LGALS3 NKX2-1 PAX8 TG TPO
36 differentiated thyroid carcinoma 29.3 BGLAP DICER1 NKX2-1 PAX8 TG TPO
37 thyroid cancer, nonmedullary, 2 29.2 CALCA LGALS3 NKX2-1 PAX8 TG THRB
38 follicular adenoma 29.0 CALCA LGALS3 NKX2-1 PAX8 SLC26A4 TG
39 congenital hypothyroidism 28.8 DUOXA2 GNAS IYD NKX2-1 PAX8 SERPINA7
40 graves disease 1 28.8 SERPINA7 TG THRB TPO TRH TSHR
41 thyroid cancer 28.6 BGLAP CALCA DICER1 GNAS LGALS3 NKX2-1
42 goiter, multinodular 2 12.3
43 goiter, multinodular 3 12.3
44 substernal goiter 12.3
45 lingual goiter 12.2
46 goiter, multinodular, cystic renal disease, and digital anomalies 12.0
47 deafness goiter stippled epiphyses 12.0
48 daneman davy mancer syndrome 11.9
49 bangstad syndrome 11.7
50 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.4

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter

Symptoms & Phenotypes for Goiter

GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.92 GNAS PAX8 SERPINA7 TRH

MGI Mouse Phenotypes related to Goiter:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.22 DICER1 GNAS NKX2-1 PAX8 SLC26A4 SLC5A5
2 homeostasis/metabolism MP:0005376 10.18 DICER1 GNAS LGALS3 NKX2-1 PAX8 SLC26A4
3 growth/size/body region MP:0005378 10.16 DICER1 GNAS LGALS3 NKX2-1 PAX8 TG
4 hematopoietic system MP:0005397 10.06 DICER1 DUOXA2 GNAS LGALS3 TG THRB
5 craniofacial MP:0005382 9.97 DICER1 DUOXA2 GNAS PAX8 THRB TPO
6 limbs/digits/tail MP:0005371 9.92 DICER1 DUOXA2 GNAS PAX8 TG THRB
7 hearing/vestibular/ear MP:0005377 9.91 GNAS PAX8 SLC26A4 THRB TPO TSHR
8 nervous system MP:0003631 9.9 DICER1 GNAS LGALS3 NKX2-1 PAX8 SLC26A4
9 neoplasm MP:0002006 9.73 DICER1 GNAS LGALS3 NKX2-1 THRB TSHR
10 no phenotypic analysis MP:0003012 9.5 DICER1 GNAS NKX2-1 PAX8 THRB TRH
11 skeleton MP:0005390 9.36 DICER1 DUOXA2 GNAS LGALS3 NKX2-1 PAX8

Drugs & Therapeutics for Goiter

Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 227)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
3
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 302-25-0
4
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable 2921-57-5
6
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
7
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
8
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
9
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7553-56-2 807
10
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
11
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
12
Methimazole Approved Phase 4,Phase 1,Phase 2,Not Applicable 60-56-0 1349907
13
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
14
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
15
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
16
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
17
Propranolol Approved, Investigational Phase 4,Phase 3,Not Applicable 525-66-6 4946
18
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
19
Bimatoprost Approved, Investigational Phase 4,Phase 3,Early Phase 1 155206-00-1 5311027
20
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
21
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 1 1177-87-3
23
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Not Applicable 93-14-1 3516
24
leucovorin Approved Phase 4,Not Applicable 58-05-9 6006 143
25
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
26
Methotrexate Approved Phase 4,Not Applicable 59-05-2, 1959-05-2 126941
27
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
28
Codeine Approved, Illicit Phase 4 76-57-3 5284371
29
Acetaminophen Approved Phase 4 103-90-2 1983
30
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
31
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable 2920-86-7
32 Autoantibodies Phase 4
33 Analgesics Phase 4,Phase 3,Phase 2
34 Anesthetics, Intravenous Phase 4
35 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Narcotics Phase 4
38 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
39 Analgesics, Opioid Phase 4
40 Hypnotics and Sedatives Phase 4
41 Anesthetics, General Phase 4
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
45 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
49 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
50 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 195)
# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
3 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
4 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
5 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
6 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
7 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
8 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
9 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
10 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
11 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
12 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
13 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
14 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
15 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
16 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
17 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
18 Minimizing Narcotic Analgesics After Endocrine Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
19 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
20 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
21 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
22 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
23 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
24 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
25 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
26 Early Levothyroxine Post Radioactive Iodine Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
27 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
28 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
29 Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Completed NCT02112370 Phase 3 Ropivacaine with epinephrine injection
30 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
31 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
32 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
33 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
34 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
35 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
36 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
37 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
38 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
39 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
40 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Active, not recruiting NCT03298867 Phase 3
41 Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study Enrolling by invitation NCT03461211 Phase 3
42 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
43 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
44 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
45 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
46 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
47 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
48 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
49 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
50 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: goiter

Genetic Tests for Goiter

Genetic tests related to Goiter:

# Genetic test Affiliating Genes
1 Goiter 29

Anatomical Context for Goiter

MalaCards organs/tissues related to Goiter:

41
Thyroid, Bone, Testes, Pituitary, Lung, Kidney, B Cells

Publications for Goiter

Articles related to Goiter:

(show top 50) (show all 2805)
# Title Authors Year
1
iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma. ( 29355489 )
2018
2
The Goitrous Salting Madonnas: Iconography of Goiter in Religious Portraits. ( 29911047 )
2018
3
Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery. ( 29682274 )
2018
4
Self-portrait with goiter: Antonio Ligabue. ( 29931475 )
2018
5
Pemberton's Sign in a Patient with a Goiter. ( 29847764 )
2018
6
Two Cases of Transiently Elevated Serum CEA Levels in Severe Hypothyroidism without Goiter. ( 29709954 )
2018
7
Serial fiber optic bronchoscopy (FOB) to predict the need of tracheostomy in tracheomalacia after thyroidectomy in long standing goiter. ( 29524827 )
2018
8
The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. ( 29619937 )
2018
9
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
10
Acute Suppurative Thyroiditis in an Intravenous Drug User with a Preexisting Goiter. ( 29780423 )
2018
11
An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter. ( 29915764 )
2018
12
Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases. ( 29406821 )
2018
13
Extracorporeal Membrane Oxygenation (ECMO)-Assisted Surgery for Mediastinal Goiter Removal. ( 29242007 )
2018
14
Amyloid goiter mimicking subacute thyroiditis on clinical and imaging findings: A case report. ( 29315620 )
2018
15
Genetic and functional analysis of two missense<i>DUOX2</i>mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
16
Evaluation of Four Variants of the Thyroid Imaging Reporting and Data System (TIRADS) Classification in Patients with Multinodular Goiter. ( 29334119 )
2018
17
Nontoxic Goiter (NTG) and Radioiodine: What Do Patients Think About It? Quality of Life in Patients with NTG Before and After 131-I Therapy. ( 29713309 )
2018
18
Calcitonin Screening in Nodular Goiter-Upper Limits. ( 29669679 )
2018
19
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
20
Letter to &amp;quot;the Prevalence of Incidental Thyroid Carcinoma in Patients Who Underwent Thyroidectomy for Multinodular Goiter&amp;quot;. ( 29581698 )
2018
21
Indications for the Surgical Management of Benign Goiter in Adults. ( 29345225 )
2018
22
A 78-Year-Old Man With Historical Goiter. ( 29600295 )
2018
23
Antero mediastinal retrosternal goiter: surgical excision by combined cervical and hybrid robot-assisted approach. ( 29707373 )
2018
24
Surgical approach to the intrathoracic goiter. ( 29721546 )
2018
25
The Iconography of Goiter: Five Sculptures in the Sacred Mountains of Varallo, Orta, and Varese in Italy. ( 29310524 )
2018
26
Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter. ( 29641730 )
2018
27
Thoracic Outlet Syndrome: A Unique Presentation of a Primary Intrathoracic Goiter. ( 29975576 )
2018
28
Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium/iodide symporter (SLC5A5) mutation in a family of Shih-Tzu dogs. ( 29777899 )
2018
29
Systemic Retinoids and Thyrotoxicosis in (Multi) Nodular Goiter: Side Effect or Coincidence? ( 29937568 )
2018
30
Successful airway management with combined use of McGrath<sup>Ar</sup> MAC video laryngoscope and fiberoptic bronchoscope in a severe obese patient with huge goiter -a case report. ( 29684995 )
2018
31
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations. ( 29538609 )
2018
32
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
33
Substernal Goiter: Correlation between Grade and Surgical Approach. ( 29580356 )
2018
34
An Enlarged Goiter Presenting with a Rare Diffuse Lipomatosis of the Thyroid Gland. ( 29987269 )
2018
35
Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region. ( 30294345 )
2018
36
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India. ( 30148098 )
2018
37
Dynamic sonographic examination of an ectopic sublingual goiter. ( 29080324 )
2018
38
Regulation of thyroid sodium-iodide symporter in different stages of goiter: Possible involvement of reactive oxygen species. ( 29112772 )
2018
39
Obviating the need for sternotomy: Safety and effectiveness of microdebrider use for retrosternal goiter. ( 29360235 )
2018
40
The effect of Metformin treatment in obese insulin-resistant patients with euthyroid goiter. ( 29452573 )
2018
41
Goiter as a Red Herring In the Triad of Obesity, Neck Compressive Symptoms, and Goiter. ( 29498918 )
2018
42
Case Image: Bovine-type aortic arch and compression of the kissing carotid arteries by a retrosternal goiter: An uncommon cause of carotid bruit. ( 29512622 )
2018
43
An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter. ( 29897006 )
2018
44
Management of retrosternal goiter: Retrospective study of 72 patients at two secondary care centers. ( 30017236 )
2018
45
Evidence of an ancient (2000 years ago) goiter attributed to iodine deficiency in North America. ( 30037617 )
2018
46
The effect of 17 years of increased salt iodization on the prevalence and nature of goiter in Croatian schoolchildren. ( 30055100 )
2018
47
Substernal goiter: Treatment and challenges. Twenty-two years of experience in diagnosis and management of substernal goiters. ( 30055961 )
2018
48
An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter. ( 30084100 )
2018
49
Graves' Disease Presenting as Painful Goiter: A Case Report and Review of the Literature. ( 30101044 )
2018
50
Goiter Prevalence and Interrelated Components from Coastal Karnataka. ( 30105567 )
2018

Variations for Goiter

Expression for Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for Goiter

GO Terms for Goiter

Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.67 CALCA GNAS TSHR
2 cellular oxidant detoxification GO:0098869 9.63 IYD TPO TXNRD2
3 hormone-mediated signaling pathway GO:0009755 9.54 THRB TRH TSHR
4 activation of adenylate cyclase activity GO:0007190 9.5 CALCA GNAS TSHR
5 hormone biosynthetic process GO:0042446 9.48 TG TPO
6 thyroid hormone metabolic process GO:0042403 9.43 IYD TG
7 cellular response to gonadotropin stimulus GO:0071371 9.4 PAX8 SLC5A5
8 thyroid hormone generation GO:0006590 9.33 IYD SLC5A5 TPO
9 thyroid-stimulating hormone signaling pathway GO:0038194 9.26 PAX8 TSHR
10 iodide transport GO:0015705 9.13 SLC26A4 SLC5A5 TG
11 thyroid gland development GO:0030878 8.92 NKX2-1 PAX8 TG THRB

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA TG TRH
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
3 iodide peroxidase activity GO:0004447 8.96 IYD TPO
4 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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