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MCID: GTR002
MIFTS: 53

Goiter

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Goiter

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MalaCards integrated aliases for Goiter:

Name: Goiter 12 29 54 15 17 71
Goitre 12 74 15

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:12176
ICD9CM 34 240.9
NCIt 49 C26785
SNOMED-CT 67 3716002
ICD10 32 E04.9
UMLS 71 C0018021
Sources

Summaries for Goiter

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Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and substernal goiter. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Remifentanil and Methimazole have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and pituitary, and related phenotypes are Decreased HPV16-GFP infection and behavior/neurological

Wikipedia : 74 A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre can be... more...

Sources

Related Diseases for Goiter

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Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 747)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 35.0 TPO TG DICER1
2 substernal goiter 34.5 TG CALCA
3 dyshormonogenic goiter 34.3 SLC26A4 IYD DUOXA2
4 toxic diffuse goiter 34.2 TSHR TPO TG SERPINA7
5 pendred syndrome 33.8 TPO TG SLC5A5 SLC26A4 PAX8 IYD
6 endemic goiter 33.8 TSHR TPO TG SLC26A4 SERPINA7 IYD
7 nontoxic goiter 33.8 TSHR TPO TG SERPINA7 CALCA BGLAP
8 nodular goiter 33.6 TSHR TPO TG SLC5A5 LGALS3 CALCA
9 plummer's disease 33.5 TSHR TPO THRB TG
10 graves' disease 33.3 TSHR TPO THRB TG SERPINA7 PAX8
11 multinodular goiter 33.3 TSHR TPO TG SLC26A4 PAX8 NKX2-1
12 familial thyroid dyshormonogenesis 32.8 TPO TG SLC5A5 IYD DUOXA2
13 hyperthyroidism 32.5 TSHR TRH TPO THRB TG SERPINA7
14 thyroid angiosarcoma 32.5 TG PAX8 NKX2-1 CALCA
15 hashimoto thyroiditis 32.2 TSHR TPO TG SLC26A4 LGALS3 CALCA
16 hypoparathyroidism 31.5 TPO GNAS CALCA BGLAP
17 congenital hypothyroidism 31.4 TSHR TPO TG SLC5A5 SLC26A4 SERPINA7
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.4 TSHR TPO TG
19 thyroid hormone resistance, generalized, autosomal dominant 31.3 TXNRD2 TSHR TRH THRB TG SERPINA7
20 myxedema 31.2 TSHR TPO TG SERPINA7
21 postsurgical hypothyroidism 31.2 TRH TPO TG
22 exophthalmos 31.2 TSHR TPO TG
23 thyroid gland anaplastic carcinoma 31.0 TSHR TPO TG SLC5A5 SLC26A4 PAX8
24 thyroid carcinoma, familial medullary 30.9 TG NKX2-1 CALCA
25 thyroid carcinoma 30.9 TSHR TPO TG NKX2-1 LGALS3 CALCA
26 thyroiditis 30.9 TSHR TRH TPO THRB TG SLC26A4
27 subacute thyroiditis 30.9 TSHR TPO TG SERPINA7
28 thyroid lymphoma 30.9 TPO TG CALCA
29 adenoma 30.9 TSHR TRH TG LGALS3 GNAS
30 thyroid gland medullary carcinoma 30.9 TG PAX8 CALCA
31 hypothyroidism, central, with testicular enlargement 30.9 TRH DUOXA2
32 fetal adenoma 30.8 TG CALCA
33 hypothyroidism, congenital, nongoitrous, 1 30.8 TSHR TG IYD GNAS DUOXA2
34 acromegaly 30.6 TRH GNAS BGLAP
35 struma ovarii 30.6 TSHR TG NKX2-1
36 iodine hypothyroidism 30.6 TSHR TPO TG
37 hypothyroidism, congenital, nongoitrous, 2 30.5 TSHR TPO TG SLC5A5 SLC26A4 SERPINA7
38 papillary thyroid microcarcinoma 30.5 TSHR TG NKX2-1 CALCA
39 differentiated thyroid carcinoma 30.5 TSHR TPO TG PAX8 NKX2-1 DICER1
40 transient congenital hypothyroidism 30.4 TSHR TPO
41 thyroid crisis 30.4 TSHR TPO THRB TG SERPINA7
42 graves disease 1 30.4 TXNRD2 TSHR TRH TPO THRB TG
43 athyreosis 30.3 TSHR TG SLC26A4 PAX8 NKX2-1
44 euthyroid sick syndrome 30.3 TRH TG SERPINA7
45 thyroid tumor 30.3 TPO THRB TG LGALS3
46 parathyroid gland disease 30.3 TG CALCA BGLAP
47 juvenile type testicular granulosa cell tumor 30.3 GNAS DICER1
48 parathyroid adenoma 30.2 LGALS3 GNAS CALCA BGLAP
49 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 30.1 TSHR SLC26A4 PAX8 NKX2-1 IYD DUOXA2
50 fibrous dysplasia 30.1 GNAS CALCA BGLAP

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter
Sources

Symptoms & Phenotypes for Goiter

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GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.62 GNAS TRH

MGI Mouse Phenotypes related to Goiter:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 DICER1 DUOXA2 GNAS LGALS3 NKX2-1 PAX8
2 homeostasis/metabolism MP:0005376 10.25 BGLAP DICER1 GNAS LGALS3 NKX2-1 PAX8
3 endocrine/exocrine gland MP:0005379 10.23 BGLAP DICER1 GNAS NKX2-1 PAX8 SLC26A4
4 nervous system MP:0003631 10.07 DICER1 GNAS LGALS3 NKX2-1 PAX8 SERPINA7
5 hearing/vestibular/ear MP:0005377 9.98 DUOXA2 GNAS PAX8 SLC26A4 THRB TPO
6 limbs/digits/tail MP:0005371 9.97 DICER1 DUOXA2 GNAS PAX8 TG THRB
7 neoplasm MP:0002006 9.8 DICER1 GNAS LGALS3 NKX2-1 THRB TSHR
8 no phenotypic analysis MP:0003012 9.7 DICER1 GNAS NKX2-1 PAX8 THRB TRH
9 reproductive system MP:0005389 9.61 BGLAP DICER1 LGALS3 NKX2-1 PAX8 SLC26A4
10 skeleton MP:0005390 9.47 BGLAP DICER1 DUOXA2 GNAS LGALS3 NKX2-1
Sources

Drugs & Therapeutics for Goiter

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Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methimazole Approved Phase 4 60-56-0 1349907
3
Dipivefrin Approved Phase 4 52365-63-6 3105
4
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
7
Codeine Approved, Illicit Phase 4 76-57-3 5284371
8
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
11
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
12
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 5283731 6433735
13 Trace Elements Phase 4
14 Anti-Infective Agents Phase 4
15 Nutrients Phase 4
16 Anti-Infective Agents, Local Phase 4
17 Micronutrients Phase 4
18 Pharmaceutical Solutions Phase 4
19 Ophthalmic Solutions Phase 4
20 Lubricant Eye Drops Phase 4
21 Guar Phase 4
22 Narcotics Phase 4
23 Analgesics Phase 4
24 Analgesics, Opioid Phase 4
25 Respiratory System Agents Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Antitussive Agents Phase 4
28 Antipyretics Phase 4
29 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
30 Hormone Antagonists Phase 4
31 Vitamins Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33
protease inhibitors Phase 4
34 Hydroxycholecalciferols Phase 4
35 glucocorticoids Phase 4
36 Antiemetics Phase 4
37 HIV Protease Inhibitors Phase 4
38 Gastrointestinal Agents Phase 4
39 Anti-Inflammatory Agents Phase 4
40 Anesthetics Phase 4
41 BB 1101 Phase 4
42 Calciferol Phase 4
43
Propylthiouracil Approved, Investigational Phase 3 51-52-5 657298
44 Antimetabolites Phase 3
45
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
46
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
47 Antithyroid Agents Phase 1, Phase 2
48 Antirheumatic Agents Phase 1, Phase 2
49 Antibodies Phase 1, Phase 2
50 Immunoglobulins Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 Comparison of Different Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy: a Prospective, Double-blinded Randomized Control Trial Unknown status NCT01761149 Phase 4 Remifentanil
2 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
3 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
4 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 TSH-adapted Therapy in a Large Randomized, Observer-blind, Placebo-controlled, Prospective Treatment Study of Patients With Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
6 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
7 The Effect of Ocular Surface Lubricant Eyedrops on Lid Parallel Conjunctival Folds (LIPCOF) and Other Signs and Symptoms of Dysfunctional Tear Syndrome Completed NCT01268735 Phase 4 Lubricating eyedrops containing hydroxypropyl-guar
8 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Active, not recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
9 The Impact of Preoperative Oral Dexamethasone Supplementation on the Biochemical Parameters and Results of Surgical Treatment in Patients With Nontoxic Multinodular Goiter Undergoing Total Thyroidectomy. Not yet recruiting NCT04412694 Phase 4 Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland).;Placebo oral sweetener (Clio tablets, sweetener with a dispenser, Instantina GES, Vienna, Austria).
10 Therapeutic Role of Levothyroxine on the Patients With Atypia of Undetermined Significance (AUS) Goiter Withdrawn NCT02329379 Phase 4 Levothyroxine
11 Ultrasound Guided Interstitial Laser Photocoagulation on Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
12 Prospective Randomized Clinical Trial of Total Thyroidectomy (Tx) Versus Thionamides (Anti-Thyroid Drugs) in Patients With Moderate-to-Severe Graves' Ophthalmopathy - a 1-year Follow-up Unknown status NCT03066076 Phase 3 Antithyroid Drug
13 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism: A Clinical Trial With Historical Control Completed NCT01039818 Phase 3
14 The Effect of 0.1 mg Recombinant Human Thyrotropin (rhTSH) on Thyroid Radioiodine-uptake and the Degree of Goiter Reduction Following 131I-therapy, in Patients With Benign Non-toxic Nodular Goiter. A Randomized, Double-blind, Placebo-controlled Trial. Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
15 Study to Evaluate the Dose, Safety and Effectiveness of Modified-Release Recombinant Human Thyroid Stimulating Hormone (MRrhTSH) When Used in Conjunction With Radioiodine for the Treatment of Multinodular Goiter. Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
16 Pretreatment With Recombinant Human Thyrotropin (rhTSH) for the Effect on Thyroid Size and Function, and for the Effect of Radioiodine Treatment in Patients With Nodular Goiter. Prospective, Randomized Double-blinded Trials. Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
17 B Cell Depletion With the Anti-CD20 Monoclonal Antibody Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2 Methimazole;Rituximab
18 Pilot Study of Teriparatide for Postsurgical Hypoparathyroidism Terminated NCT01171690 Phase 2 Teriparatide
19 Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules Completed NCT03257930 Phase 1 ethanol injection
20 Phase I Study Comparing Pharmacokinetics and Safety Profile of Thyrogen Versus a Modified Release of Recombinant Human Thyroid Stimulating Hormone Completed NCT00137891 Phase 1 Modified Release rhTSH
21 K1-70 - A Phase I, Single Ascending Intramuscular Dose or Single Ascending Intravenous Dose, Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in Subjects With Graves' Disease Recruiting NCT02904330 Phase 1 K1-70 intramuscular or K1-70 intravenous
22 The Impact of Surgical Treatment of Benign Non-toxic Goiter on the Voice Function Unknown status NCT02468921
23 Cases of Goiter in Children Attending Assiut University Children Hospital Unknown status NCT03202160
24 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery - a Prospective Cohort Study Unknown status NCT03100357
25 New Thyroid Fine Needle Biopsy Apparatus Unknown status NCT01512212
26 I-124 PET/US for Benign Thyroid Diseases - Blinded, Multicentric Assessment of Augmented Thyroid Work-up Versus Regular Thyroid Diagnostics Unknown status NCT03128255
27 Risk Factors of Incidence of Hypothyroidism in Patients With Type 1 Diabetes Unknown status NCT03257566
28 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease. A Randomized, Prospective Study Unknown status NCT01658085
29 Is Superior Laryngeal Nerve Really Safe During Thyroidectomy Using Ultrasonic Dissector. Unknown status NCT01812395
30 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
31 Application of Digital Infrared Thermal Imaging in Thyroid Disease and Associated Ophthalmopathy and Dermopathy Unknown status NCT01182584
32 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
33 Alterations in Quality of Life After Thyroidectomy for Benign Thyroid Disease Unknown status NCT03566537
34 Comparative Analysis Between A Bipolar Vessel Sealing and Cutting Device and the Tie and Suture Technique in Thyroidectomy: A Two Institution Randomized Clinical Trial Unknown status NCT02140476
35 Identification of Differentially Expressed Proteins in Parathyroid Tumors and Their Clinical Correlation With the Disease Unknown status NCT01647503
36 Thyroid Dysfunction and Dyslipidemia in Patients With Chronic Kidney Diseases Unknown status NCT03277911
37 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Unknown status NCT03091140
38 Long-Term Follow-up and Outcome of Administering Recombinant Human Thyrotropin as an Adjuvant of Therapy With Radioiodine in the Outpatient Treatment of Multinodular Goitres Completed NCT00509483
39 Is the Use of Drain for Thyroid Surgery Realistic? Completed NCT01771523
40 The Impact of Surgical Treatment of Benign Non-toxic Goiter on Quality of Life Completed NCT02651818
41 Five-year Follow up of a Randomized Clinical Trial of Bilateral Subtotal Thyroidectomy Versus Total Thyroidectomy for Graves' Disease. Completed NCT01408368
42 Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients With Nodular Goiter: A Prospective Cohort Study Completed NCT03072654
43 The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter Completed NCT01384786
44 Arathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function Completed NCT02194920
45 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
46 A Study to Measure the Effect of Switching the Salt Supply From Non-iodized to Iodized on Cognitive Development in Ethiopia Completed NCT01349634
47 Five-year Follow up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter. Completed NCT00946894
48 Congenital Hypothyroidism Due to Thyroglobulin Mutations in an Inbred Brazilian Family: A Novel Compound Heterozygous Constellation and Intronic Mutation Related to Fetal Goiter. Completed NCT00493103
49 Subtotal Versus Total Thyroidectomy for Benign Thyroid Disease - a Prospective Case-control Surgical Outcome Study. Completed NCT01273714
50 Sutureless Thyroidectomy Versus Conventional Thyroidectomy: Prospective Randomized Clinical Trial Completed NCT03615456

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 71 / NDF-RT 50 :


levothyroxine
Levothyroxine Sodium
liothyronine
liothyronine sodium
Methimazole
Propylthiouracil
Thyroglobulin
THYROID (BEEF)
thyroid (USP)
THYROID PWDR
Sources

Genetic Tests for Goiter

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Genetic tests related to Goiter:

# Genetic test Affiliating Genes
1 Goiter 29
Sources

Anatomical Context for Goiter

About this section

MalaCards organs/tissues related to Goiter:

40
Thyroid, Testes, Pituitary, Bone, Breast, Heart, Lymph Node
Sources

Publications for Goiter

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Articles related to Goiter:

(show top 50) (show all 17942)
# Title Authors PMID Year
1
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 54 61
20153806 2010
2
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 54 61
20153805 2010
3
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 61 54
20093166 2010
4
United detection GNAS and TSHR mutations in subclinical toxic multinodular goiter. 54 61
19826830 2010
5
The incidence of Hashimoto's disease in nodular goitre: the concordance in serological and cytological findings. 54 61
20089015 2010
6
Environmental pollutants and the thyroid. 54 61
19942155 2009
7
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 61 54
19762181 2009
8
Prevalence of hypothyroidism in benign breast disorders and effect of thyroxine replacement on the clinical outcome. 54 61
19641955 2009
9
The DREAM protein is associated with thyroid enlargement and nodular development. 61 54
19299442 2009
10
A Family of H723R Mutation for SLC26A4 Associated with Enlarged Vestibular Aqueduct Syndrome. 54 61
19565036 2009
11
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 54 61
19731774 2009
12
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 54 61
19554808 2009
13
Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. 54 61
19196800 2009
14
The prevalence of iodine deficiency, serum thyroglobulin, anti-thyroglobulin and thyroid peroxidase antibody levels in the urban areas of Kayseri, Central Anatolia. 54 61
19194833 2009
15
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. 61 54
19606248 2009
16
A family with a novel TSH receptor activating germline mutation (p.Ala485Val). 54 61
18175146 2008
17
Does response bias influence population studies of thyroid disorders? 54 61
18690797 2008
18
Methods to assess iron and iodine status. 54 61
18598585 2008
19
NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. 61 54
18187871 2008
20
Iodine requirements and the risks and benefits of correcting iodine deficiency in populations. 61 54
18565420 2008
21
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies. 61 54
17940114 2008
22
A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism. 61 54
18025759 2007
23
Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. 61 54
18075286 2007
24
Recurrence of the p.R277X/p.R1511X compound heterozygous mutation in the thyroglobulin gene in unrelated families with congenital goiter and hypothyroidism: haplotype analysis using intragenic thyroglobulin polymorphisms. 54 61
17911408 2007
25
Congenital hypothyroidism with goitre caused by new mutations in the thyroglobulin gene. 54 61
17532758 2007
26
[Pendrin: physiology, molecular biology and clinical importance]. 61 54
17659500 2007
27
Elevated thyroid peroxidase antibodies with encephalopathy in MELAS syndrome. 61 54
17560506 2007
28
Galectin-3 and CD44v6 positivity by RT-PCR method in fine needle aspirates of benign thyroid lesions. 54 61
17397496 2007
29
Soy protein isolates of varied isoflavone content do not influence serum thyroid hormones in healthy young men. 61 54
17316115 2007
30
Molecular analysis of hearing loss associated with enlarged vestibular aqueduct in the mainland Chinese: a unique SLC26A4 mutation spectrum. 54 61
17443271 2007
31
A study on dyslipidaemia in subclinical hypothyroidism. 61 54
17444061 2006
32
[Long-term follow up after antithyroid drug treatment in Graves' disease]. 61 54
16916174 2006
33
SLC26A4 gene is frequently involved in nonsyndromic hearing impairment with enlarged vestibular aqueduct in Caucasian populations. 54 61
16570074 2006
34
[The expression of galectin-3 in nodular thyroid goitre]. 61 54
16831319 2006
35
Clinical and laboratory aspects of thyroid autoantibodies. 61 54
16704751 2006
36
[Prevalence of autoimmunological disorders of the thyroid in children in the Białystok population]. 61 54
17338121 2006
37
Functional characterization of wild-type and a mutated form of SLC26A4 identified in a patient with Pendred syndrome. 54 61
16791000 2006
38
Fast fluorometric method for measuring pendrin (SLC26A4) Cl-/I- transport activity. 54 61
16914891 2006
39
Intrauterine diagnosis and management of fetal goitrous hypothyroidism: a report of an Iranian family with three consecutive pregnancies complicated by fetal goiter. 54 61
16405406 2005
40
[Expression and clinical significance of galectin-3 in well-differentiated thyroid carcinoma]. 61 54
16552965 2005
41
The expression of wild-type pendrin (SLC26A4) in human embryonic kidney (HEK 293 Phoenix) cells leads to the activation of cationic currents. 61 54
16260428 2005
42
Mutations in the thyrotropin receptor signal transduction pathway in the hyperfunctioning thyroid nodules from multinodular goiters: a study in the Turkish population. 54 61
16284436 2005
43
[Autoimmune thyroid disease--clinical symptoms of associated autoimmunity]. 61 54
16405252 2005
44
Ghrelin in human medullary thyroid carcinomas. 54 61
16181236 2005
45
Sensitive thyrotropin and thyrotropin-receptor antibody determinations one month after discontinuation of antithyroid drug treatment as predictors of relapse in Graves' disease. 54 61
16187913 2005
46
Naturally occurring mutations in the thyroglobulin gene. 54 61
16187910 2005
47
High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations. 54 61
16187918 2005
48
Prevalence of goiter among schoolchildren from Gorgan, Iran, a decade after national iodine supplementation: association with age, gender, and thyroperoxidase antibodies. 61 54
16277169 2005
49
Effect of 10 yr of the iodine supplementation on the hearing threshold of iodine deficient schoolchildren. 54 61
16218041 2005
50
Expression of pendrin in benign and malignant human thyroid tissues. 54 61
15942636 2005
Sources

Variations for Goiter

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Sources

Expression for Goiter

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Search GEO for disease gene expression data for Goiter.
Sources

Pathways for Goiter

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Pathways related to Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 36
Show member pathways
 12.42 TSHR TPO TG SLC5A5 SLC26A4 SERPINA7
2
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.33 TSHR PAX8 GNAS
3
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.09 THRB CALCA BGLAP
4
Amine-derived hormones 65
Show member pathways
 10.93 TPO SLC5A5 IYD
5
Thyroxine (Thyroid Hormone) Production 1
9.8 TSHR TRH TPO TG SLC5A5
Sources

GO Terms for Goiter

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Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.67 TSHR GNAS CALCA
2 cellular oxidant detoxification GO:0098869 9.63 TXNRD2 TPO IYD
3 hormone-mediated signaling pathway GO:0009755 9.54 TSHR TRH THRB
4 activation of adenylate cyclase activity GO:0007190 9.5 TSHR GNAS CALCA
5 hormone biosynthetic process GO:0042446 9.48 TPO TG
6 thyroid hormone metabolic process GO:0042403 9.43 TG IYD
7 cellular response to gonadotropin stimulus GO:0071371 9.4 SLC5A5 PAX8
8 iodide transport GO:0015705 9.33 TG SLC5A5 SLC26A4
9 thyroid-stimulating hormone signaling pathway GO:0038194 9.26 TSHR PAX8
10 thyroid gland development GO:0030878 9.26 THRB TG PAX8 NKX2-1
11 thyroid hormone generation GO:0006590 8.92 TPO TG SLC5A5 IYD

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 TRH TG CALCA
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC5A5 SLC26A4
3 thyroid-stimulating hormone receptor activity GO:0004996 8.96 TSHR PAX8
4 iodide peroxidase activity GO:0004447 8.62 TPO IYD
Sources

Sources for Goiter

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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