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MCID: GTR002
MIFTS: 52

Goiter

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Goiter

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MalaCards integrated aliases for Goiter:

Name: Goiter 12 29 55 44 15 73
Goitre 12 76

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:12176
ICD10 33 E04.9
ICD9CM 35 240.9
MeSH 44 D006042
NCIt 50 C26785
UMLS 73 C0018021
Sources

Summaries for Goiter

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Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and plummer's disease. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Remifentanil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and bone, and related phenotypes are Decreased HPV16-GFP infection and homeostasis/metabolism

Wikipedia : 76 A goitre or goiter is a swelling in the neck resulting from an enlarged thyroid gland. The term is also... more...

Sources

Related Diseases for Goiter

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Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 34.7 DICER1 TG TPO
2 plummer's disease 33.2 TG THRB TPO
3 pendred syndrome 33.0 PAX8 SLC26A4 TG TPO
4 nodular goiter 33.0 CALCA LGALS3 TG TPO TSHR
5 dyshormonogenic goiter 32.8 DUOXA2 SERPINA7 SLC26A4 TG
6 endemic goiter 32.7 CALCA SERPINA7 TG TPO TSHR
7 toxic diffuse goiter 32.6 SERPINA7 TG TPO TRH TSHR
8 graves' disease 32.6 SERPINA7 TG THRB TPO TSHR
9 nontoxic goiter 32.1 BGLAP CALCA SERPINA7 TG TPO TSHR
10 familial thyroid dyshormonogenesis 31.9 DUOXA2 IYD SLC5A5 TG TPO
11 anaplastic thyroid cancer 31.2 NKX2-1 PAX8 TG TPO
12 hashimoto thyroiditis 30.9 CALCA LGALS3 SLC26A4 TG TPO TSHR
13 myxedema 30.7 TG TPO TSHR
14 suppurative thyroiditis 30.7 CALCA TG
15 multinodular goiter 30.7 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
16 acute thyroiditis 30.4 CALCA TG
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.3 TG TPO TSHR
18 ovarian germ cell teratoma 30.2 NKX2-1 TG
19 thyroid carcinoma, familial medullary 30.0 CALCA NKX2-1 TG
20 struma ovarii 29.9 NKX2-1 TG TSHR
21 hyperthyroidism 29.9 BGLAP GNAS SERPINA7 TG THRB TPO
22 subacute thyroiditis 29.8 SERPINA7 TG TPO TSHR
23 fibrous dysplasia 29.6 BGLAP CALCA GNAS
24 thyroid hormone resistance, generalized, autosomal dominant 29.6 SERPINA7 TG THRB TRH TXNRD2
25 papillary thyroid microcarcinoma 29.6 CALCA NKX2-1 TG TSHR
26 neonatal hypothyroidism 29.3 PAX8 SLC5A5 TG TPO TSHR
27 thyroid cancer, nonmedullary, 1 29.2 LGALS3 NKX2-1 PAX8 TG
28 hyperthyroxinemia 29.2 SERPINA7 TPO TRH TSHR
29 hypothyroidism, congenital, nongoitrous, 2 28.4 LGALS3 NKX2-1 PAX8 SERPINA7 SLC26A4 TG
30 thyroiditis 28.3 CALCA SERPINA7 TG THRB TPO TRH
31 differentiated thyroid carcinoma 27.9 BGLAP DICER1 NKX2-1 PAX8 TG TPO
32 papillary carcinoma 27.5 CALCA LGALS3 NKX2-1 PAX8 TG TPO
33 congenital hypothyroidism 27.5 DUOXA2 IYD NKX2-1 PAX8 SLC5A5 TG
34 thyroid cancer, nonmedullary, 2 27.1 CALCA LGALS3 NKX2-1 PAX8 TG THRB
35 follicular adenoma 26.9 CALCA LGALS3 NKX2-1 PAX8 SLC26A4 TG
36 hypothyroidism 25.7 CALCA DUOXA2 GNAS IYD NKX2-1 PAX8
37 thyroid cancer 24.5 CALCA GNAS LGALS3 NKX2-1 PAX8 SLC26A4
38 goiter, multinodular 2 12.1
39 goiter, multinodular 3 12.1
40 substernal goiter 12.1
41 lingual goiter 12.1
42 goiter, multinodular, cystic renal disease, and digital anomalies 11.9
43 deafness goiter stippled epiphyses 11.8
44 daneman davy mancer syndrome 11.8
45 bangstad syndrome 11.5
46 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.2
47 blepharochalasis and double lip 10.9
48 thyroid dyshormonogenesis 3 10.9
49 short stature, microcephaly, and endocrine dysfunction 10.9
50 subacute lymphocytic thyroiditis 10.9 TG TPO

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter
Sources

Symptoms & Phenotypes for Goiter

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GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.92 GNAS PAX8 SERPINA7 TRH

MGI Mouse Phenotypes related to Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 DICER1 GNAS LGALS3 NKX2-1 PAX8 SLC26A4
2 endocrine/exocrine gland MP:0005379 10.17 TPO TRH TSHR DICER1 GNAS NKX2-1
3 craniofacial MP:0005382 9.93 DICER1 DUOXA2 GNAS PAX8 THRB TPO
4 nervous system MP:0003631 9.9 DICER1 GNAS LGALS3 NKX2-1 PAX8 SLC26A4
5 hearing/vestibular/ear MP:0005377 9.88 TPO TSHR GNAS PAX8 SLC26A4 THRB
6 limbs/digits/tail MP:0005371 9.87 PAX8 THRB TPO TSHR DICER1 DUOXA2
7 neoplasm MP:0002006 9.73 TSHR DICER1 GNAS LGALS3 NKX2-1 THRB
8 no phenotypic analysis MP:0003012 9.5 DICER1 GNAS NKX2-1 PAX8 THRB TRH
9 skeleton MP:0005390 9.32 DICER1 DUOXA2 GNAS LGALS3 NKX2-1 PAX8
Sources

Drugs & Therapeutics for Goiter

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Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 219)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
6
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
7
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7553-56-2 807
8
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
9
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
10
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
11
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
12
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
13
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
14
Propranolol Approved, Investigational Phase 4,Phase 3,Not Applicable 525-66-6 4946
15
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
16
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
17
Ephedrine Approved Phase 4 299-42-3 9294
18
Pseudoephedrine Approved Phase 4 90-82-4 7028
19
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
20
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
21
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 4,Not Applicable 58-05-9 143 6006
24
Dinoprost Investigational Phase 4 551-11-1 5283078
25 Autoantibodies Phase 4
26 Analgesics Phase 4,Phase 3,Phase 2
27 Analgesics, Opioid Phase 4
28 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
29 Anesthetics, General Phase 4
30 Anesthetics, Intravenous Phase 4
31 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
32 Hypnotics and Sedatives Phase 4
33 Narcotics Phase 4
34 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
36 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
45 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3,Not Applicable
46 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Not Applicable
47 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
48 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3,Not Applicable
49 Prednisolone phosphate Phase 4,Phase 2,Phase 3,Not Applicable
50 Protective Agents Phase 4,Phase 2,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 188)
# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
3 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
4 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
5 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
6 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
7 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
8 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
9 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
10 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
11 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
12 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
13 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
14 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
15 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
16 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
17 Minimizing Narcotic Analgesics After Endocrine Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
18 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
19 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
20 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
21 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
22 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
23 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
24 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
25 Early Levothyroxine Post Radioactive Iodine Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
26 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
27 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
28 Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Completed NCT02112370 Phase 3 Ropivacaine with epinephrine injection
29 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
30 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
31 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
32 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
33 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
34 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
35 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
36 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Recruiting NCT03298867 Phase 3
37 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
38 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
39 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
40 Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study Enrolling by invitation NCT03461211 Phase 3
41 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
42 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
43 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
44 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
45 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
46 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
47 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
48 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
49 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos
50 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: goiter

Sources

Genetic Tests for Goiter

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Genetic tests related to Goiter:

# Genetic test Affiliating Genes
1 Goiter 29
Sources

Anatomical Context for Goiter

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MalaCards organs/tissues related to Goiter:

41
Thyroid, Eye, Bone, Testes, B Cells, T Cells, Breast
Sources

Publications for Goiter

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Articles related to Goiter:

(show top 50) (show all 1685)
# Title Authors Year
1
iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma. ( 29355489 )
2018
2
The Goitrous Salting Madonnas: Iconography of Goiter in Religious Portraits. ( 29911047 )
2018
3
Displacement of the Recurrent Laryngeal Nerve in Patients with Recurrent Goiter Undergoing Redo Thyroid Surgery. ( 29682274 )
2018
4
Self-portrait with goiter: Antonio Ligabue. ( 29931475 )
2018
5
Pemberton's Sign in a Patient with a Goiter. ( 29847764 )
2018
6
Two Cases of Transiently Elevated Serum CEA Levels in Severe Hypothyroidism without Goiter. ( 29709954 )
2018
7
Serial fiber optic bronchoscopy (FOB) to predict the need of tracheostomy in tracheomalacia after thyroidectomy in long standing goiter. ( 29524827 )
2018
8
The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. ( 29619937 )
2018
9
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
10
Acute Suppurative Thyroiditis in an Intravenous Drug User with a Preexisting Goiter. ( 29780423 )
2018
11
An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter. ( 29915764 )
2018
12
Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases. ( 29406821 )
2018
13
Extracorporeal Membrane Oxygenation (ECMO)-Assisted Surgery for Mediastinal Goiter Removal. ( 29242007 )
2018
14
Amyloid goiter mimicking subacute thyroiditis on clinical and imaging findings: A case report. ( 29315620 )
2018
15
Genetic and functional analysis of two missense<i>DUOX2</i>mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
16
Evaluation of Four Variants of the Thyroid Imaging Reporting and Data System (TIRADS) Classification in Patients with Multinodular Goiter. ( 29334119 )
2018
17
Nontoxic Goiter (NTG) and Radioiodine: What Do Patients Think About It? Quality of Life in Patients with NTG Before and After 131-I Therapy. ( 29713309 )
2018
18
Calcitonin Screening in Nodular Goiter-Upper Limits. ( 29669679 )
2018
19
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
20
Indications for the Surgical Management of Benign Goiter in Adults. ( 29345225 )
2018
21
A 78-Year-Old Man With Historical Goiter. ( 29600295 )
2018
22
Antero mediastinal retrosternal goiter: surgical excision by combined cervical and hybrid robot-assisted approach. ( 29707373 )
2018
23
Surgical approach to the intrathoracic goiter. ( 29721546 )
2018
24
The Iconography of Goiter: Five Sculptures in the Sacred Mountains of Varallo, Orta, and Varese in Italy. ( 29310524 )
2018
25
Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter. ( 29641730 )
2018
26
Thoracic Outlet Syndrome: A Unique Presentation of a Primary Intrathoracic Goiter. ( 29975576 )
2018
27
Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium/iodide symporter (SLC5A5) mutation in a family of Shih-Tzu dogs. ( 29777899 )
2018
28
Systemic Retinoids and Thyrotoxicosis in (Multi) Nodular Goiter: Side Effect or Coincidence? ( 29937568 )
2018
29
Successful airway management with combined use of McGrath<sup>Ar</sup> MAC video laryngoscope and fiberoptic bronchoscope in a severe obese patient with huge goiter -a case report. ( 29684995 )
2018
30
Multinodular Goiter Progression Toward Malignancy in a Case of DICER1 Syndrome: Histologic and Molecular Alterations. ( 29538609 )
2018
31
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
32
Substernal Goiter: Correlation between Grade and Surgical Approach. ( 29580356 )
2018
33
Obviating the need for sternotomy: Safety and effectiveness of microdebrider use for retrosternal goiter. ( 29360235 )
2018
34
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
35
Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. ( 28190186 )
2017
36
Poor dietary diversity, wealth status and use of un-iodized salt are associated with goiter among school children: a cross-sectional study in Ethiopia. ( 28061776 )
2017
37
Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid Gland Associated with Amyloid Goiter: A Medullary Thyroid Carcinoma Mimic on Intra-operative Frozen Section. ( 28879586 )
2017
38
Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. ( 28684549 )
2017
39
Airway Considerations in Case of a Large Multinodular Goiter. ( 29284884 )
2017
40
Simultaneous unilateral anterior thoracoscopy with transcervical thyroidectomy for the resection of large mediastinal thyroid goiter. ( 28932554 )
2017
41
The first serological evidence for Rift Valley fever infection in the camel, goitered gazelle and Anatolian water buffaloes in Turkey. ( 28861841 )
2017
42
Less than total thyroidectomy for goiter: when and how? ( 29322022 )
2017
43
Giant Cervical Goiter With Posterior Mediastinal Extension. ( 28929034 )
2017
44
Successful combined surgical approach of a rare retrotracheal goiter in a patient with anatomical impediments. ( 28832090 )
2017
45
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
46
Prevalence of goiter and associated factors among schoolchildren in northeast Ethiopia. ( 29172409 )
2017
47
Role of intraoperative neuromonitoring of the recurrent laryngeal nerves during thyroid reoperations of recurrent goiter. ( 28703113 )
2017
48
Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter. ( 28942461 )
2017
49
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
50
Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients with Nodular Goiter: A Prospective Cohort Study. ( 29234624 )
2017
Sources

Variations for Goiter

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Expression for Goiter

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Search GEO for disease gene expression data for Goiter.
Sources

Pathways for Goiter

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Pathways related to Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.52 DUOXA2 GNAS IYD PAX8 SERPINA7 SLC26A4
2
G alpha (s) signalling events 66
11.71 CALCA GNAS TSHR
3
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.33 GNAS PAX8 TSHR
4
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.09 BGLAP CALCA THRB
5
Amine-derived hormones 66
Show member pathways
 10.93 IYD SLC5A5 TPO
6
Thyroxine (Thyroid Hormone) Production 1
9.8 SLC5A5 TG TPO TRH TSHR
Sources

GO Terms for Goiter

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Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.65 IYD TPO TXNRD2
2 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.61 CALCA GNAS TSHR
3 hormone-mediated signaling pathway GO:0009755 9.54 THRB TRH TSHR
4 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.51 GNAS TSHR
5 activation of adenylate cyclase activity GO:0007190 9.5 CALCA GNAS TSHR
6 hormone biosynthetic process GO:0042446 9.49 TG TPO
7 thyroid hormone metabolic process GO:0042403 9.46 IYD TG
8 cellular response to gonadotropin stimulus GO:0071371 9.4 PAX8 SLC5A5
9 thyroid hormone generation GO:0006590 9.33 IYD SLC5A5 TPO
10 thyroid-stimulating hormone signaling pathway GO:0038194 9.26 PAX8 TSHR
11 thyroid gland development GO:0030878 9.26 NKX2-1 PAX8 TG THRB
12 iodide transport GO:0015705 8.8 SLC26A4 SLC5A5 TG

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA TG TRH
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
3 thyroid-stimulating hormone receptor activity GO:0004996 8.96 PAX8 TSHR
4 iodide peroxidase activity GO:0004447 8.62 IYD TPO
Sources

Sources for Goiter

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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