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MCID: GTR002
MIFTS: 54

Goiter

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Goiter

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MalaCards integrated aliases for Goiter:

Name: Goiter 12 30 56 45 15 17 74
Goitre 12 77 15

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:12176
ICD9CM 36 240.9
MeSH 45 D006042
NCIt 51 C26785
SNOMED-CT 69 3716002
ICD10 34 E04.9
UMLS 74 C0018021
Sources

Summaries for Goiter

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Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and endemic goiter. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Remifentanil and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and bone, and related phenotypes are Decreased HPV16-GFP infection and endocrine/exocrine gland

Wikipedia : 77 A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre can be... more...

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Related Diseases for Goiter

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Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 382)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 34.5 DICER1 TG TPO
2 endemic goiter 33.6 SERPINA7 TG TPO TSHR
3 plummer's disease 33.6 TG THRB TPO
4 pendred syndrome 33.4 PAX8 SLC26A4 TG TPO
5 nodular goiter 33.3 CALCA LGALS3 SLC5A5 TG TPO TSHR
6 toxic diffuse goiter 33.1 SERPINA7 TG TPO TRH TSHR
7 dyshormonogenic goiter 33.1 DUOXA2 SERPINA7 SLC26A4 TG
8 graves' disease 33.0 GNAS SERPINA7 TG TPO TSHR
9 nontoxic goiter 32.9 BGLAP CALCA SERPINA7 TG TPO TSHR
10 multinodular goiter 32.4 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
11 familial thyroid dyshormonogenesis 32.0 DUOXA2 IYD SLC5A5 TG TPO
12 hashimoto thyroiditis 31.7 CALCA LGALS3 SLC26A4 TG TPO TSHR
13 hyperthyroidism 31.2 BGLAP GNAS SERPINA7 TG THRB TPO
14 myxedema 30.8 TG TPO TSHR
15 thyroid hormone resistance, generalized, autosomal dominant 30.7 SERPINA7 TG THRB TRH TXNRD2
16 hypothyroidism, congenital, nongoitrous, 1 30.6 GNAS TSHR
17 suppurative thyroiditis 30.4 CALCA TG
18 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 30.3 TG TPO
19 thyroid carcinoma, familial medullary 30.2 CALCA NKX2-1 TG
20 hypothyroidism, congenital, nongoitrous, 2 30.1 LGALS3 NKX2-1 PAX8 SERPINA7 SLC26A4 TG
21 hypothyroidism, congenital, nongoitrous, 4 30.0 SERPINA7 TG TPO TRH
22 subacute thyroiditis 30.0 SERPINA7 TG TPO TSHR
23 ovarian germ cell teratoma 29.9 NKX2-1 TG
24 postsurgical hypothyroidism 29.9 TG TRH TSHR
25 papillary thyroid microcarcinoma 29.8 CALCA NKX2-1 TG TSHR
26 struma ovarii 29.8 NKX2-1 TG TSHR
27 thyroid crisis 29.8 SERPINA7 TG THRB
28 fibrous dysplasia 29.7 BGLAP CALCA GNAS
29 graves disease 1 29.5 SERPINA7 TG THRB TPO TRH TSHR
30 hyperthyroxinemia 29.4 SERPINA7 TPO TRH TSHR
31 athyreosis 29.4 NKX2-1 PAX8 SLC26A4 TG TSHR
32 generalized resistance to thyroid hormone 29.4 THRB TRH TXNRD2
33 hypothyroidism 29.3 CALCA DUOXA2 GNAS IYD NKX2-1 PAX8
34 thyroiditis 29.3 CALCA SERPINA7 TG THRB TPO TRH
35 papillary carcinoma 29.1 CALCA LGALS3 NKX2-1 PAX8 TG TPO
36 differentiated thyroid carcinoma 29.0 BGLAP DICER1 NKX2-1 PAX8 TG TPO
37 thyroid cancer, nonmedullary, 2 28.8 CALCA LGALS3 NKX2-1 PAX8 TG THRB
38 follicular adenoma 28.5 CALCA LGALS3 NKX2-1 PAX8 SLC26A4 TG
39 congenital hypothyroidism 28.1 DUOXA2 GNAS IYD NKX2-1 PAX8 SERPINA7
40 thyroid cancer 27.7 BGLAP CALCA DICER1 GNAS LGALS3 NKX2-1
41 goiter, multinodular 2 12.4
42 goiter, multinodular 3 12.4
43 substernal goiter 12.3
44 lingual goiter 12.3
45 goiter, multinodular, cystic renal disease, and digital anomalies 12.1
46 deafness goiter stippled epiphyses 12.0
47 daneman davy mancer syndrome 12.0
48 bangstad syndrome 11.7
49 thyroid dyshormonogenesis 3 11.5
50 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.4

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter
Sources

Symptoms & Phenotypes for Goiter

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GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.92 GNAS PAX8 SERPINA7 TRH

MGI Mouse Phenotypes related to Goiter:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.22 DICER1 GNAS NKX2-1 PAX8 SLC26A4 SLC5A5
2 homeostasis/metabolism MP:0005376 10.18 DICER1 GNAS LGALS3 NKX2-1 PAX8 SLC26A4
3 growth/size/body region MP:0005378 10.16 DICER1 GNAS LGALS3 NKX2-1 PAX8 TG
4 hematopoietic system MP:0005397 10.06 DICER1 DUOXA2 GNAS LGALS3 TG THRB
5 craniofacial MP:0005382 9.97 DICER1 DUOXA2 GNAS PAX8 THRB TPO
6 limbs/digits/tail MP:0005371 9.92 DICER1 DUOXA2 GNAS PAX8 TG THRB
7 hearing/vestibular/ear MP:0005377 9.91 GNAS PAX8 SLC26A4 THRB TPO TSHR
8 nervous system MP:0003631 9.9 DICER1 GNAS LGALS3 NKX2-1 PAX8 SLC26A4
9 neoplasm MP:0002006 9.73 DICER1 GNAS LGALS3 NKX2-1 THRB TSHR
10 no phenotypic analysis MP:0003012 9.5 DICER1 GNAS NKX2-1 PAX8 THRB TRH
11 skeleton MP:0005390 9.36 DICER1 DUOXA2 GNAS LGALS3 NKX2-1 PAX8
Sources

Drugs & Therapeutics for Goiter

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Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
3
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 302-25-0
4
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-24-8 5755
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Not Applicable 2921-57-5
6
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 83-43-2 6741
7
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
8
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7553-56-2 807
9
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
10
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
11
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3 51-84-3 187
12
Methimazole Approved Phase 4,Phase 1,Phase 2,Not Applicable 60-56-0 1349907
13
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
14
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
15
Propranolol Approved, Investigational Phase 4,Phase 3,Not Applicable 525-66-6 4946
16
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
17
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
18
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
19
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
20
Bimatoprost Approved, Investigational Phase 4,Phase 3,Early Phase 1 155206-00-1 5311027
21
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 1 1177-87-3
23
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Not Applicable 93-14-1 3516
24
leucovorin Approved Phase 4,Not Applicable 58-05-9 143 6006
25
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
26
Methotrexate Approved Phase 4,Not Applicable 1959-05-2, 59-05-2 126941
27
Hyaluronic acid Approved, Vet_approved Phase 4,Not Applicable 9004-61-9 53477741
28
Acetaminophen Approved Phase 4 103-90-2 1983
29
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
30
Codeine Approved, Illicit Phase 4 76-57-3 5284371
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-30-3 6037
32
Prednisolone hemisuccinate Experimental Phase 4,Phase 2,Phase 3,Not Applicable 2920-86-7
33 Autoantibodies Phase 4
34 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
35 Analgesics Phase 4,Phase 2
36 Analgesics, Opioid Phase 4
37 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
38 Narcotics Phase 4
39 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
40 Protective Agents Phase 4,Phase 2,Phase 3,Not Applicable
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
42 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
43 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Methylprednisolone Acetate Phase 4,Phase 2,Phase 3,Not Applicable
45 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
46 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Prednisolone acetate Phase 4,Phase 2,Phase 3,Not Applicable
50 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 200)
# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
3 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
4 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
5 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
6 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
7 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
8 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
9 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
10 Short-term Prednisone to Treat STA Study(SPTSS) Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
11 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
12 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
13 99Tc-MDP for Thyroid-Associated Ophthalmopathy Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
14 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
15 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
16 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
17 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
18 Minimizing Narcotic Analgesics After Endocrine Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
19 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
20 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
21 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
22 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
23 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
24 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
25 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
26 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
27 Early Levothyroxine Post Radioactive Iodine Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
28 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
29 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
30 Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Completed NCT02112370 Phase 3 Ropivacaine with epinephrine injection
31 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
32 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
33 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
34 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
35 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
36 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
37 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
38 Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg
39 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
40 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
41 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Active, not recruiting NCT03298867 Phase 3
42 Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study Enrolling by invitation NCT03461211 Phase 3
43 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
44 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
45 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
46 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
47 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
48 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
49 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
50 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: goiter

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Genetic Tests for Goiter

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Genetic tests related to Goiter:

# Genetic test Affiliating Genes
1 Goiter 30
Sources

Anatomical Context for Goiter

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MalaCards organs/tissues related to Goiter:

42
Thyroid, Eye, Bone, Pituitary, Testes, Lung, Heart
Sources

Publications for Goiter

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Articles related to Goiter:

(show top 50) (show all 4895)
# Title Authors Year
1
Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report. ( 30702624 )
2019
2
Machine Learning Approach to find the relation between Endometriosis, benign breast disease, cystitis and non-toxic goiter. ( 30932000 )
2019
3
Metformin reduces risk of benign nodular goiter in patients with type 2 diabetes mellitus. ( 30986765 )
2019
4
Exophthalmos and multinodular goitre, an unusual combination. ( 31051471 )
2019
5
Management of retrosternal goiter: Retrospective study of 72 patients at two secondary care centers. ( 30017236 )
2019
6
Substernal goiter: Treatment and challenges. Twenty-two years of experience in diagnosis and management of substernal goiters. ( 30055961 )
2019
7
Goiter Prevalence and Interrelated Components from Coastal Karnataka. ( 30105567 )
2019
8
A Remarkable Uptake of FDG in Huge Mediastinal Hashimoto's Goiter. ( 30146569 )
2019
9
Unexpected Bone Metastases in 99mTc-Pertechnetate Scan of Recurrent Goiter. ( 30300206 )
2019
10
Recurrent goiter: risk factors, patient quality of life, and efficacy of radioiodine therapy. ( 30516760 )
2019
11
A lute player peasant with nodular goiter by Bartolomeo Passarotti (1529-1592). ( 30628045 )
2019
12
A marked goiter involved in Marine-Lenhart syndrome. ( 30631661 )
2019
13
Do Different Species of Sargassum in Haizao Yuhu Decoction Cause Different Effects in a Rat Goiter Model? ( 30723515 )
2019
14
The representation of a goiter by Renaissance painter Moretto da Brescia. ( 30778906 )
2019
15
African statue with goiter. ( 30788771 )
2019
16
The Impact of Esophageal Compression on Goiter Symptoms before and after Thyroid Surgery. ( 30800637 )
2019
17
Treatment of Toxic Multinodular Goiter: Comparison of Radioiodine and Long-Term Methimazole Treatment. ( 30803411 )
2019
18
Self-portrait with goiter: Antonio Ligabue. ( 29931475 )
2019
19
Death due to external compression of the trachea in a patient with multinodular hemorrhagic goiter. ( 30820869 )
2019
20
Corrigendum to "Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects". ( 30838044 )
2019
21
Retrosternal goiter presenting as deep vein thrombosis of the arm. ( 30880038 )
2019
22
Ultrasound-Guided Percutaneous Microwave Ablation for Substernal Goiter: Initial Experience. ( 30900322 )
2019
23
Detection Rate of Thyroid Papillary Micro-carcinoma in Multinodular Goiter Surgery. ( 30925960 )
2019
24
Goiter and its associated factors among primary school children aged 6-12 years in Anchar district, Eastern Ethiopia. ( 30947246 )
2019
25
The wide spectrum of DUOX2 deficiency: from life-threatening compressive goiter in infancy to lifelong euthyroidism. ( 31030636 )
2019
26
Thyroiditis process as a predictive factor of sternotomy in the treatment of cervico-mediastinal goiter. ( 31074402 )
2019
27
Takotsubo cardiomyopathy associated with cerebral infarction following surgery for euthyroid goiter. ( 31103314 )
2019
28
Toxic nodular goiter and thyroid cancer: Is hyperthyroidism protective against thyroid cancer? ( 31104806 )
2019
29
Acute respiratory failure secondary to a cervical goitre in a pregnant woman: a case report. ( 30696398 )
2019
30
Stroke in Association with Thyroid Goitre: A Case Report. ( 30935806 )
2019
31
Acute airway obstruction due to benign multinodular goitre. ( 30996065 )
2019
32
Current Practice of Surgery for Benign Goitre-An Analysis of the Prospective DGAV StuDoQ|Thyroid Registry. ( 30965665 )
2019
33
Predictors of the need for an extracervical approach to intrathoracic goitre. ( 30957064 )
2019
34
Goitre Is No Longer Prevalent and Urinary Iodine Excretion Is above Normal among School Going Children in Jabalpur, India: Is This Major Health Problem Already Solved? ( 30690623 )
2019
35
Cytological features of dyshormonogenetic goitre: A diagnostic pitfall. ( 30417955 )
2019
36
Cough syncope and tracheal compression secondary to a retrosternal goitre: looking for a pulmonary embolism. ( 31028051 )
2019
37
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
38
An Enlarged Goiter Presenting with a Rare Diffuse Lipomatosis of the Thyroid Gland. ( 29987269 )
2018
39
Mutational Profile of Papillary Thyroid Carcinoma in an Endemic Goiter Region of North India. ( 30148098 )
2018
40
Applicability of a shortened interpretation model for intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism in an endemic goiter region. ( 30294345 )
2018
41
Clinico-Pathological Profile of Anaplastic Thyroid Carcinoma in an Endemic Goiter Area. ( 30766820 )
2018
42
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. ( 29284787 )
2018
43
Genetic and functional analysis of two missense DUOX2 mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
44
Substernal Goiter: Correlation between Grade and Surgical Approach. ( 29580356 )
2018
45
Letter to "the Prevalence of Incidental Thyroid Carcinoma in Patients Who Underwent Thyroidectomy for Multinodular Goiter". ( 29581698 )
2018
46
A 78-Year-Old Man With Historical Goiter. ( 29600295 )
2018
47
The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter. ( 29619937 )
2018
48
Substernal goiter presenting as acute respiratory failure. ( 29622368 )
2018
49
Systemic Retinoids and Thyrotoxicosis in (Multi) Nodular Goiter: Side Effect or Coincidence? ( 29937568 )
2018
50
Evidence of an ancient (2000 years ago) goiter attributed to iodine deficiency in North America. ( 30037617 )
2018
Sources

Variations for Goiter

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Sources

Expression for Goiter

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Search GEO for disease gene expression data for Goiter.
Sources

Pathways for Goiter

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Pathways related to Goiter according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 38
Show member pathways
 12.52 DUOXA2 GNAS IYD PAX8 SERPINA7 SLC26A4
2
G alpha (s) signalling events 67
11.71 CALCA GNAS TSHR
3
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.33 GNAS PAX8 TSHR
4
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.09 BGLAP CALCA THRB
5
Amine-derived hormones 67
Show member pathways
 10.93 IYD SLC5A5 TPO
6
Thyroxine (Thyroid Hormone) Production 1
9.8 SLC5A5 TG TPO TRH TSHR
Sources

GO Terms for Goiter

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Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.67 CALCA GNAS TSHR
2 cellular oxidant detoxification GO:0098869 9.63 IYD TPO TXNRD2
3 hormone-mediated signaling pathway GO:0009755 9.54 THRB TRH TSHR
4 activation of adenylate cyclase activity GO:0007190 9.5 CALCA GNAS TSHR
5 hormone biosynthetic process GO:0042446 9.48 TG TPO
6 thyroid hormone metabolic process GO:0042403 9.43 IYD TG
7 cellular response to gonadotropin stimulus GO:0071371 9.4 PAX8 SLC5A5
8 thyroid hormone generation GO:0006590 9.33 IYD SLC5A5 TPO
9 thyroid-stimulating hormone signaling pathway GO:0038194 9.26 PAX8 TSHR
10 iodide transport GO:0015705 9.13 SLC26A4 SLC5A5 TG
11 thyroid gland development GO:0030878 8.92 NKX2-1 PAX8 TG THRB

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA TG TRH
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
3 iodide peroxidase activity GO:0004447 8.96 IYD TPO
4 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR
Sources

Sources for Goiter

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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