Aliases & Classifications for Goiter

MalaCards integrated aliases for Goiter:

Name: Goiter 12 29 54 44 15 17 71
Goitre 12 74 15

Classifications:



External Ids:

Disease Ontology 12 DOID:12176
ICD9CM 34 240.9
MeSH 44 D006042
NCIt 50 C26785
SNOMED-CT 67 237568003
ICD10 32 E04.9
UMLS 71 C0018021

Summaries for Goiter

Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and nodular goiter. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Remifentanil and Caffeine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and breast, and related phenotypes are Decreased HPV16-GFP infection and behavior/neurological

Wikipedia : 74 A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland. A goitre can be... more...

Related Diseases for Goiter

Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 723)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 33.1 TPO TG DICER1
2 nodular goiter 32.7 TSHR TPO TG SLC5A5 CALCA
3 substernal goiter 32.6 TG CALCA
4 pendred syndrome 32.4 TPO TG SLC5A5 SLC26A4 PAX8 IYD
5 endemic goiter 32.3 TSHR TPO TG SLC26A4 SERPINA7 IYD
6 plummer's disease 32.3 TSHR TPO TG SERPINA7
7 toxic diffuse goiter 32.2 TSHR TPO TG SERPINA7
8 dyshormonogenic goiter 32.2 SLC26A4 IYD DUOXA2
9 graves' disease 32.1 TSHR TPO THRB TG SERPINA7 PAX8
10 nontoxic goiter 32.0 TSHR TPO TG SERPINA7 CALCA BGLAP
11 hashimoto thyroiditis 31.8 TSHR TPO TG SLC26A4 SERPINA7 CALCA
12 multinodular goiter 31.6 TSHR TPO TG SLC26A4 PAX8 NKX2-1
13 familial thyroid dyshormonogenesis 31.6 TPO TG SLC5A5 IYD DUOXA2 DUOX2
14 hypothyroidism, congenital, nongoitrous, 2 31.6 TSHR TG SLC26A4 PAX8
15 hyperthyroidism 31.5 TSHR TRH TPO THRB TG SERPINA7
16 thyroid angiosarcoma 31.4 TG PAX8 NKX2-1 CALCA
17 adenoma 31.4 TSHR TRH TG GNAS
18 thyroiditis 31.3 TSHR TPO TG SERPINA7 CALCA
19 hypoparathyroidism 31.2 TPO GNAS CALCA BGLAP
20 thyroid carcinoma 31.1 TSHR TPO TG SLC5A5 PAX8 NKX2-1
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 TSHR TPO TG
22 thyroid gland anaplastic carcinoma 31.0 TSHR TPO TG SLC5A5 SLC26A4 PAX8
23 myxedema 31.0 TSHR TPO TG SERPINA7
24 postsurgical hypothyroidism 30.9 TSHR TPO TG
25 thyroid hormone resistance, generalized, autosomal dominant 30.9 TXNRD2 TSHR TRH THRB TG SERPINA7
26 exophthalmos 30.8 TSHR TPO TG
27 papillary carcinoma 30.7 TSHR TPO TG PAX8 NKX2-1 CALCA
28 thyroid carcinoma, familial medullary 30.7 TG NKX2-1 CALCA
29 parathyroid adenoma 30.7 GNAS CALCA BGLAP
30 primary hyperparathyroidism 30.6 GNAS CALCA BGLAP
31 subacute thyroiditis 30.6 TSHR TPO TG SERPINA7
32 acromegaly 30.5 TRH GNAS BGLAP
33 fetal adenoma 30.5 TG CALCA
34 thyroid gland medullary carcinoma 30.4 TG PAX8 NKX2-1 CALCA
35 ovarian germ cell teratoma 30.3 TG NKX2-1
36 hypothyroidism, central, with testicular enlargement 30.3 TRH DUOXA2
37 graves disease 1 30.3 TXNRD2 TSHR TRH TPO THRB TG
38 congenital hypothyroidism 30.3 TSHR TRH TPO TG SLC5A5 SLC26A4
39 thyroid crisis 30.2 TSHR TPO TG SERPINA7
40 papillary thyroid microcarcinoma 30.2 TSHR TG NKX2-1 CALCA
41 differentiated thyroid carcinoma 30.2 TSHR TPO TG PAX8 NKX2-1 DICER1
42 struma ovarii 30.2 TSHR TG NKX2-1
43 follicular adenoma 30.2 TSHR TPO TG SLC26A4 PAX8 NKX2-1
44 multiple endocrine neoplasia 30.1 TG GNAS CALCA
45 permanent congenital hypothyroidism 30.1 TPO DUOX2
46 iodine hypothyroidism 30.0 TSHR TPO TG
47 malignant struma ovarii 30.0 TG NKX2-1
48 thyroid gland cancer 30.0 TSHR TPO TG SLC5A5 PAX8 NKX2-1
49 benign teratoma 30.0 TG PAX8 NKX2-1
50 juvenile type testicular granulosa cell tumor 30.0 GNAS DICER1

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter

Symptoms & Phenotypes for Goiter

GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.62 GNAS TRH

MGI Mouse Phenotypes related to Goiter:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 DICER1 DUOX2 DUOXA2 GNAS NKX2-1 PAX8
2 endocrine/exocrine gland MP:0005379 10.25 BGLAP DICER1 DUOX2 GNAS NKX2-1 PAX8
3 homeostasis/metabolism MP:0005376 10.24 BGLAP DICER1 DUOX2 DUOXA2 GNAS NKX2-1
4 cardiovascular system MP:0005385 10.16 DICER1 DUOX2 DUOXA2 GNAS NKX2-1 PAX8
5 hearing/vestibular/ear MP:0005377 10.06 DUOX2 DUOXA2 GNAS PAX8 SLC26A4 SLC5A5
6 nervous system MP:0003631 10 DICER1 DUOX2 GNAS NKX2-1 PAX8 SLC26A4
7 limbs/digits/tail MP:0005371 9.92 DICER1 DUOXA2 GNAS PAX8 TG THRB
8 no phenotypic analysis MP:0003012 9.7 DICER1 GNAS NKX2-1 PAX8 THRB TRH
9 reproductive system MP:0005389 9.61 BGLAP DICER1 DUOX2 NKX2-1 PAX8 SLC26A4
10 skeleton MP:0005390 9.47 BGLAP DICER1 DUOX2 DUOXA2 GNAS NKX2-1

Drugs & Therapeutics for Goiter

Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Caffeine Approved Phase 4 58-08-2 2519
3
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
6
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
7
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
8
Acetaminophen Approved Phase 4 103-90-2 1983
9
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
10
Codeine Approved, Illicit Phase 4 76-57-3 5284371
11
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
12
Calcifediol Approved, Nutraceutical Phase 4 19356-17-3 6433735 5283731
13 Antirheumatic Agents Phase 4
14 Mesalamine Phase 4 89-57-6
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4
16 Calcium Supplement Phase 4
17 Antithyroid Agents Phase 4
18 Nutrients Phase 4
19 Trace Elements Phase 4
20 Anti-Infective Agents Phase 4
21 Anti-Infective Agents, Local Phase 4
22 Micronutrients Phase 4
23 Hormone Antagonists Phase 4
24 Hormones Phase 4
25 Anesthetics Phase 4
26 Anti-Inflammatory Agents Phase 4
27 Pharmaceutical Solutions Phase 4
28 Gastrointestinal Agents Phase 4
29 Vitamins Phase 4
30 glucocorticoids Phase 4
31 BB 1101 Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 Antiemetics Phase 4
34 Calcium, Dietary Phase 4
35 Hydroxycholecalciferols Phase 4
36 Calciferol Phase 4
37 HIV Protease Inhibitors Phase 4
38
protease inhibitors Phase 4
39 Narcotics Phase 4
40 Analgesics, Opioid Phase 4
41 Analgesics Phase 4
42 Analgesics, Non-Narcotic Phase 4
43 Respiratory System Agents Phase 4
44 Antitussive Agents Phase 4
45 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
46 Antipyretics Phase 4
47
Calcium Nutraceutical Phase 4 7440-70-2 271
48
Hydroxychloroquine Approved 118-42-3 3652
49
Bupivacaine Approved, Investigational 38396-39-3, 2180-92-9 2474
50
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Comparison of Different Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy: a Prospective, Double-blinded Randomized Control Trial Unknown status NCT01761149 Phase 4 Remifentanil
2 CLINICAL MANAGEMENT OF CHILDHOOD INTESTINAL LYMPHOID NODULAR HYPERPLASIA: A RANDOMIZED CONTROLLED CLINICAL TRIAL. Unknown status NCT01789294 Phase 4 Mesalamine
3 The Influence of Continuous Treatment With Antithyroid Drugs on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150137 Phase 4 Methimazole
4 The Influence of Continuous Block-replacement Therapy on the Effect of Radioiodine in Patients With Hyperthyroidism Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
5 TSH-adapted Therapy in a Large Randomized, Observer-blind, Placebo-controlled, Prospective Treatment Study of Patients With Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
6 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
7 Evaluation of the Role of Low Dose Magnesium Sulfate in Anesthesia for Toxic Goiter Resection: A Randomized Controlled Trial Recruiting NCT04632524 Phase 4 MgSO4
8 The Impact of Preoperative Oral Dexamethasone Supplementation on the Biochemical Parameters and Results of Surgical Treatment in Patients With Nontoxic Multinodular Goiter Undergoing Total Thyroidectomy. Recruiting NCT04412694 Phase 4 Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland).;Placebo oral sweetener (Clio tablets, sweetener with a dispenser, Instantina GES, Vienna, Austria).
9 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Active, not recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
10 Therapeutic Role of Levothyroxine on the Patients With Atypia of Undetermined Significance (AUS) Goiter Withdrawn NCT02329379 Phase 4 Levothyroxine
11 The Effect of 0.1 mg Recombinant Human Thyrotropin (rhTSH) on Thyroid Radioiodine-uptake and the Degree of Goiter Reduction Following 131I-therapy, in Patients With Benign Non-toxic Nodular Goiter. A Randomized, Double-blind, Placebo-controlled Trial. Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
12 Study to Evaluate the Dose, Safety and Effectiveness of Modified-Release Recombinant Human Thyroid Stimulating Hormone (MRrhTSH) When Used in Conjunction With Radioiodine for the Treatment of Multinodular Goiter. Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
13 Pretreatment With Recombinant Human Thyrotropin (rhTSH) for the Effect on Thyroid Size and Function, and for the Effect of Radioiodine Treatment in Patients With Nodular Goiter. Prospective, Randomized Double-blinded Trials. Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
14 Comparative Analysis Between A Bipolar Vessel Sealing and Cutting Device and the Tie and Suture Technique in Thyroidectomy: A Two Institution Randomized Clinical Trial Unknown status NCT02140476
15 Harmonic FOCUS Versus Conventional Technique in Total Thyroidectomy for Benign Thyroid Disease. A Randomized, Prospective Study Unknown status NCT01658085
16 Clinical Investigations on Cytokin-Gradients in Hypo/Euthyroid Patients. Evaluation of Expression of Different Pro-and Anti-Inflammatory Cyto-/Chemokines in Skin Wounds After Surgery of Benign Goitres (Struma Multinodosa) or Malignant Diseases of Thyroid Gland (Papillary Thyroid Carcinoma) in Correlation to the Status of Wound Healing of the Neck Wound Unknown status NCT00929318
17 Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery - a Prospective Cohort Study Unknown status NCT03100357
18 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
19 ThyrOp: Individual Subclinical Hypothyroidism After Hemithyroidectomy for Benign Nontoxic Goiter - Focus on Weight Gain and Mitochondrial Dysfunction Unknown status NCT01358136
20 Cases of Goiter in Children Attending Assiut University Children Hospital Unknown status NCT03202160
21 The Impact of Surgical Treatment of Benign Non-toxic Goiter on the Voice Function Unknown status NCT02468921
22 Is Superior Laryngeal Nerve Really Safe During Thyroidectomy Using Ultrasonic Dissector. Unknown status NCT01812395
23 I-124 PET/US for Benign Thyroid Diseases - Blinded, Multicentric Assessment of Augmented Thyroid Work-up Versus Regular Thyroid Diagnostics Unknown status NCT03128255
24 Contrast Enhanced Ultrasound for the Evaluation of Focal Liver Lesions - a Multi-center Study on the Usefulness in the Clinical Practice Unknown status NCT01329458
25 Long-Term Follow-up and Outcome of Administering Recombinant Human Thyrotropin as an Adjuvant of Therapy With Radioiodine in the Outpatient Treatment of Multinodular Goitres Completed NCT00509483
26 A Study to Measure the Effect of Switching the Salt Supply From Non-iodized to Iodized on Cognitive Development in Ethiopia Completed NCT01349634
27 Association of Thyroid Autoimmunity and Chronic Urticaria in Taiwan Completed NCT00737451
28 Harmonic Focus Shears Versus Clamp-and-technique for Total Thyroidectomy Completed NCT01003652
29 Pilot Study on Laser Ablation of Symptomatic Benign Thyroid Masses Completed NCT00615537
30 Thyroidectomy Improves Tracheal Anatomy and Airflow in Patients With Nodular Goiter: A Prospective Cohort Study Completed NCT03072654
31 Diagnosis Interest of Galectin 3 Dosage in Nodular and Multinodular Goiter Pretreatment Completed NCT01588288
32 Randomized Placebo Controlled Clinical Study of Anethum Graveolens L. (Dill) in Thyroiditis and Nodular Goiter Patients Completed NCT04482907
33 A Prospective Randomized Equivalence Trial to Evaluate the Safety of the Ligasure in Thyroid Surgery Completed NCT01163565
34 Randomized Controlled Trial of Bipolar Versus Ultrasonic Hemostasis Techniques in Thyroidectomy Completed NCT00524966
35 Prevention of Iodinated Contrast Media Induced Hyperthyroidism in Patients With Euthyroid Goiter Completed NCT04304794 Prophylactic administration of antithyroid drugs before iodinated contrast media exposure
36 Swallowing Function Before and After Surgery for Thyroid Goiter Completed NCT00205348
37 The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter Completed NCT01384786
38 Levothyroxine Treatment in Thyroid Benign Nodular Goiter Completed NCT00552253 Levothyroxin treatment
39 The Impact of Surgical Treatment of Benign Non-toxic Goiter on Quality of Life Completed NCT02651818
40 Five-year Follow up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter. Completed NCT00946894
41 Congenital Hypothyroidism Due to Thyroglobulin Mutations in an Inbred Brazilian Family: A Novel Compound Heterozygous Constellation and Intronic Mutation Related to Fetal Goiter. Completed NCT00493103
42 Delta Neutrophil Index and Neutrophil Lymphocyte Ratio in Differentiation of Thyroid Malignancy and Nodular Goiter Completed NCT04425512
43 Immediate Postoperative Course of Patients With Mini Video Assisted Total Thyroidectomy (miVAT) Versus Classic Total Thyroidectomy (cTT) Completed NCT00692835
44 Classic Total Thyroidectomy With or Without Drains Completed NCT00691990
45 Five-year Follow up of a Randomized Clinical Trial of Unilateral Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively Completed NCT00941551 levothyroxine;no levothyroxine
46 Subtotal Versus Total Thyroidectomy for Benign Thyroid Disease - a Prospective Case-control Surgical Outcome Study. Completed NCT01273714
47 Accuracy of Ultrasound Elastastography in Thyroid Nodular Disease. Completed NCT01102127
48 Is the Use of Drain for Thyroid Surgery Realistic? Completed NCT01771523
49 Comparison of Esthetic Results Between Subcuticular Suture and Synthetic Glue in Thyroidectomy Incision: a RCT Completed NCT00754182
50 Late Postoperative Course of Patients With Mini Video Assisted Thyroidectomy (miVAT) Versus Classic Thyroidectomy (T) Completed NCT00693147

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 71 / NDF-RT 51 :


levothyroxine
Levothyroxine Sodium
liothyronine
liothyronine sodium
Methimazole
Propylthiouracil
Thyroglobulin
THYROID (BEEF)
thyroid (USP)
THYROID PWDR

Cochrane evidence based reviews: goiter

Genetic Tests for Goiter

Genetic tests related to Goiter:

# Genetic test Affiliating Genes
1 Goiter 29

Anatomical Context for Goiter

MalaCards organs/tissues related to Goiter:

40
Thyroid, Pituitary, Breast, Lymph Node, Endothelial, Tongue, Kidney

Publications for Goiter

Articles related to Goiter:

(show top 50) (show all 18284)
# Title Authors PMID Year
1
Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. 61 54
20093166 2010
2
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. 61 54
20153806 2010
3
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. 61 54
20153805 2010
4
United detection GNAS and TSHR mutations in subclinical toxic multinodular goiter. 61 54
19826830 2010
5
The incidence of Hashimoto's disease in nodular goitre: the concordance in serological and cytological findings. 61 54
20089015 2010
6
Environmental pollutants and the thyroid. 61 54
19942155 2009
7
Prevalence of hypothyroidism in benign breast disorders and effect of thyroxine replacement on the clinical outcome. 61 54
19641955 2009
8
More hypothyroidism and less hyperthyroidism with sufficient iodine nutrition compared to mild iodine deficiency--a comparative population-based study of older people. 54 61
19762181 2009
9
The DREAM protein is associated with thyroid enlargement and nodular development. 61 54
19299442 2009
10
A Family of H723R Mutation for SLC26A4 Associated with Enlarged Vestibular Aqueduct Syndrome. 61 54
19565036 2009
11
Persistence of goitre in children post-salt iodization in Islamic Republic of Iran: autoimmune status. 54 61
19731774 2009
12
Evolution of sonographic appearance of the thyroid gland in children with Hashimoto's thyroiditis. 61 54
19554808 2009
13
Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. 54 61
19196800 2009
14
The prevalence of iodine deficiency, serum thyroglobulin, anti-thyroglobulin and thyroid peroxidase antibody levels in the urban areas of Kayseri, Central Anatolia. 61 54
19194833 2009
15
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. 61 54
19606248 2009
16
A family with a novel TSH receptor activating germline mutation (p.Ala485Val). 54 61
18175146 2008
17
Does response bias influence population studies of thyroid disorders? 54 61
18690797 2008
18
Methods to assess iron and iodine status. 54 61
18598585 2008
19
NIS mRNA expression level in resected thyroid tissue as a marker of postoperative hypothyroidism after subtotal thyroidectomy in patients with Graves' disease. 61 54
18187871 2008
20
Iodine requirements and the risks and benefits of correcting iodine deficiency in populations. 61 54
18565420 2008
21
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies. 54 61
17940114 2008
22
A novel thyrotropin receptor germline mutation (Asp617Tyr) causing hereditary hyperthyroidism. 61 54
18025759 2007
23
Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. 61 54
18075286 2007
24
Recurrence of the p.R277X/p.R1511X compound heterozygous mutation in the thyroglobulin gene in unrelated families with congenital goiter and hypothyroidism: haplotype analysis using intragenic thyroglobulin polymorphisms. 61 54
17911408 2007
25
Congenital hypothyroidism with goitre caused by new mutations in the thyroglobulin gene. 54 61
17532758 2007
26
[Pendrin: physiology, molecular biology and clinical importance]. 54 61
17659500 2007
27
Elevated thyroid peroxidase antibodies with encephalopathy in MELAS syndrome. 54 61
17560506 2007
28
Galectin-3 and CD44v6 positivity by RT-PCR method in fine needle aspirates of benign thyroid lesions. 54 61
17397496 2007
29
Soy protein isolates of varied isoflavone content do not influence serum thyroid hormones in healthy young men. 54 61
17316115 2007
30
Molecular analysis of hearing loss associated with enlarged vestibular aqueduct in the mainland Chinese: a unique SLC26A4 mutation spectrum. 61 54
17443271 2007
31
A study on dyslipidaemia in subclinical hypothyroidism. 54 61
17444061 2006
32
[Long-term follow up after antithyroid drug treatment in Graves' disease]. 61 54
16916174 2006
33
[The expression of galectin-3 in nodular thyroid goitre]. 61 54
16831319 2006
34
SLC26A4 gene is frequently involved in nonsyndromic hearing impairment with enlarged vestibular aqueduct in Caucasian populations. 61 54
16570074 2006
35
Clinical and laboratory aspects of thyroid autoantibodies. 54 61
16704751 2006
36
[Prevalence of autoimmunological disorders of the thyroid in children in the Białystok population]. 61 54
17338121 2006
37
Fast fluorometric method for measuring pendrin (SLC26A4) Cl-/I- transport activity. 54 61
16914891 2006
38
Functional characterization of wild-type and a mutated form of SLC26A4 identified in a patient with Pendred syndrome. 54 61
16791000 2006
39
Intrauterine diagnosis and management of fetal goitrous hypothyroidism: a report of an Iranian family with three consecutive pregnancies complicated by fetal goiter. 61 54
16405406 2005
40
[Expression and clinical significance of galectin-3 in well-differentiated thyroid carcinoma]. 61 54
16552965 2005
41
The expression of wild-type pendrin (SLC26A4) in human embryonic kidney (HEK 293 Phoenix) cells leads to the activation of cationic currents. 61 54
16260428 2005
42
Mutations in the thyrotropin receptor signal transduction pathway in the hyperfunctioning thyroid nodules from multinodular goiters: a study in the Turkish population. 61 54
16284436 2005
43
[Autoimmune thyroid disease--clinical symptoms of associated autoimmunity]. 54 61
16405252 2005
44
Ghrelin in human medullary thyroid carcinomas. 54 61
16181236 2005
45
Sensitive thyrotropin and thyrotropin-receptor antibody determinations one month after discontinuation of antithyroid drug treatment as predictors of relapse in Graves' disease. 54 61
16187913 2005
46
Prevalence of goiter among schoolchildren from Gorgan, Iran, a decade after national iodine supplementation: association with age, gender, and thyroperoxidase antibodies. 54 61
16277169 2005
47
High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations. 61 54
16187918 2005
48
Naturally occurring mutations in the thyroglobulin gene. 61 54
16187910 2005
49
Effect of 10 yr of the iodine supplementation on the hearing threshold of iodine deficient schoolchildren. 54 61
16218041 2005
50
Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling. 61 54
15817662 2005

Variations for Goiter

Expression for Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for Goiter

GO Terms for Goiter

Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.67 TSHR GNAS CALCA
2 cellular oxidant detoxification GO:0098869 9.67 TXNRD2 TPO IYD DUOX2
3 hormone-mediated signaling pathway GO:0009755 9.63 TSHR TRH THRB
4 activation of adenylate cyclase activity GO:0007190 9.61 TSHR GNAS CALCA
5 positive regulation of cell motility GO:2000147 9.51 DUOXA2 DUOX2
6 hormone biosynthetic process GO:0042446 9.5 TPO TG DUOX2
7 cellular response to gonadotropin stimulus GO:0071371 9.48 SLC5A5 PAX8
8 thyroid hormone metabolic process GO:0042403 9.43 TG IYD DUOX2
9 thyroid-stimulating hormone signaling pathway GO:0038194 9.4 TSHR PAX8
10 iodide transport GO:0015705 9.33 TG SLC5A5 SLC26A4
11 thyroid gland development GO:0030878 9.26 TG PAX8 NKX2-1 DUOX2
12 thyroid hormone generation GO:0006590 9.02 TPO TG SLC5A5 IYD DUOX2

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 TRH TG CALCA
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC5A5 SLC26A4
3 thyroid-stimulating hormone receptor activity GO:0004996 8.96 TSHR PAX8
4 iodide peroxidase activity GO:0004447 8.62 TPO IYD

Sources for Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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