MNG2
MCID: GTR013
MIFTS: 15

Goiter, Multinodular 2 (MNG2)

Categories: Endocrine diseases

Aliases & Classifications for Goiter, Multinodular 2

MalaCards integrated aliases for Goiter, Multinodular 2:

Name: Goiter, Multinodular 2 57 71
Goiter, Multinodular, 2 57 13
Mng2 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
x-linked dominant

Miscellaneous:
mean age of onset 20.6 years


HPO:

31
goiter, multinodular 2:
Inheritance x-linked dominant inheritance


Classifications:



External Ids:

OMIM® 57 300273
OMIM Phenotypic Series 57 PS138800
MedGen 41 C1846033
UMLS 71 C1846033

Summaries for Goiter, Multinodular 2

OMIM® : 57 Multinodular goiter is a common disorder characterized by nodular enlargement of the thyroid gland. It occurs with a female:male ratio of 5:1 (summary by Capon et al., 2000). For additional phenotypic information and a discussion of genetic heterogeneity of multinodular goiter, see MNG1 (138800). (300273) (Updated 05-Mar-2021)

MalaCards based summary : Goiter, Multinodular 2, also known as goiter, multinodular, 2, is related to multinodular goiter and goiter. An important gene associated with Goiter, Multinodular 2 is MNG2 (Multinodular Goiter 2). Affiliated tissues include thyroid, and related phenotype is euthyroid multinodular goiter.

Related Diseases for Goiter, Multinodular 2

Diseases in the Multinodular Goiter family:

Goiter, Multinodular 2 Goiter, Multinodular 3

Diseases related to Goiter, Multinodular 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 multinodular goiter 11.1
2 goiter 11.1

Symptoms & Phenotypes for Goiter, Multinodular 2

Human phenotypes related to Goiter, Multinodular 2:

31
# Description HPO Frequency HPO Source Accession
1 euthyroid multinodular goiter 31 HP:0000866

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Endocrine Features:
euthyroid multinodular goiter
thyroid volume 22-66ml (adults)

Head And Neck Neck:
thyroid goiter (diffuse or nodular)

Clinical features from OMIM®:

300273 (Updated 05-Mar-2021)

Drugs & Therapeutics for Goiter, Multinodular 2

Search Clinical Trials , NIH Clinical Center for Goiter, Multinodular 2

Genetic Tests for Goiter, Multinodular 2

Anatomical Context for Goiter, Multinodular 2

MalaCards organs/tissues related to Goiter, Multinodular 2:

40
Thyroid

Publications for Goiter, Multinodular 2

Articles related to Goiter, Multinodular 2:

# Title Authors PMID Year
1
Mapping a dominant form of multinodular goiter to chromosome Xp22. 57
10986044 2000
2
Putative Novel Serotypes '33' and '35' in Clinically Healthy Small Ruminants in Mongolia Expand the Group of Atypical BTV. 61
33383902 2020
3
Mutational analysis of Peroxiredoxin IV: exclusion of a positional candidate for multinodular goitre. 61
12135533 2002

Variations for Goiter, Multinodular 2

Expression for Goiter, Multinodular 2

Search GEO for disease gene expression data for Goiter, Multinodular 2.

Pathways for Goiter, Multinodular 2

GO Terms for Goiter, Multinodular 2

Sources for Goiter, Multinodular 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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