MCID: GND015
MIFTS: 18

Gonadal Germ Cell Tumor

Categories: Rare diseases

Aliases & Classifications for Gonadal Germ Cell Tumor

MalaCards integrated aliases for Gonadal Germ Cell Tumor:

Name: Gonadal Germ Cell Tumor 59

Classifications:



External Ids:

Orphanet 59 ORPHA363582

Summaries for Gonadal Germ Cell Tumor

MalaCards based summary : Gonadal Germ Cell Tumor is related to nonseminomatous germ cell tumor and seminoma. An important gene associated with Gonadal Germ Cell Tumor is AFP (Alpha Fetoprotein). The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include testis, brain and ovary.

Related Diseases for Gonadal Germ Cell Tumor

Graphical network of the top 20 diseases related to Gonadal Germ Cell Tumor:



Diseases related to Gonadal Germ Cell Tumor

Symptoms & Phenotypes for Gonadal Germ Cell Tumor

Drugs & Therapeutics for Gonadal Germ Cell Tumor

Drugs for Gonadal Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Gastrointestinal Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Anti-Allergic Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Histamine H1 Antagonists Phase 3
8 Histamine Antagonists Phase 3
9 Dermatologic Agents Phase 3
10 Serotonin Agents Phase 3
11
Histamine Phosphate Phase 3 51-74-1 65513
12 Antipruritics Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride

Search NIH Clinical Center for Gonadal Germ Cell Tumor

Genetic Tests for Gonadal Germ Cell Tumor

Anatomical Context for Gonadal Germ Cell Tumor

MalaCards organs/tissues related to Gonadal Germ Cell Tumor:

41
Testis, Brain, Ovary

Publications for Gonadal Germ Cell Tumor

Articles related to Gonadal Germ Cell Tumor:

(show all 28)
# Title Authors PMID Year
1
Gonadoblastoma-Associated Mixed Gonadal Germ Cell Tumor with Dysgerminoma and Hepatoid Yolk Sac Tumor Components in 46XY Gonadal Dysgenesis. 38
31175959 2019
2
[Transformation of teratoma in rabdomiosarcoma]. 38
30694192 2019
3
Cancer Incidence in Adolescents and Young Adults in 24 Selected Populations of Latin America. 38
29634431 2018
4
Pericardial effusion as an atypical initial presentation of extra-gonadal nonseminomatous germ cell tumor: a case report and literature review. 38
29492268 2018
5
Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru. 38
30018640 2018
6
Mixed Gonadal Germ Cell Tumor Composed of a Spermatocytic Tumor-Like Component and Germinoma Arising in Gonadoblastoma in a Phenotypic Woman With a 46, XX Peripheral Karyotype: Report of the First Case. 38
28614211 2017
7
A practical guide for evaluating gonadal germ cell tumor predisposition in differences of sex development. 38
28544305 2017
8
Cover Image, Volume 175C, Number 2, June 2017. 38
28621506 2017
9
Atypical presentation of sacrococcygeal yolk sac tumor in infant: beware of the injuries of the gluteal region. 38
27635156 2016
10
Metastatic sacrococcygeal yolk sac tumor: A misleading diagnosis. 38
26167024 2015
11
Vulvar yolk sac tumor diagnosed during pregnancy, with recurrence during subsequent second pregnancy. 38
26076163 2015
12
Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment. 38
25066726 2014
13
[Modified BEP regimen leads to abatement of choriocarcinoma syndrome in a patient with extra gonadal germ cell tumor : a case report]. 38
24882231 2014
14
[A suspected case of extra-gonadal germ cell tumor complicated with choriocarcinoma syndrome]. 38
23719141 2013
15
Androgen insensitivity syndrome. 38
23044881 2012
16
Germ cell tumor of ovary with plenty of sarcoid like granulomas: A diagnosis on fine needle aspiration cytology. 38
23112468 2012
17
[Case of far-advanced retroperitoneal extra-gonadal germ cell tumor responding to intensive treatment including multi-drug chemotherapy with peripheral blood stem cell transplantation and residual tumor removal]. 38
20387517 2010
18
Primary gonadal germ cell tumor associated with acute leukemia with common cytogenetics. 38
19949012 2010
19
[Treatment outcome of children and adolescents with germ cell tumor after combined therapy---a report of 44 cases]. 38
17166380 2006
20
[A non-seminomatous extra-gonadal germ cell tumor responding to intensive treatment: a case report]. 38
16972631 2006
21
Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report. 38
15546481 2004
22
Diagnostic significance of soluble c-kit in the cerebrospinal fluid of patients with germ cell tumors. 38
12134909 2002
23
Malignant sacrococcygeal yolk sac (endodermal sinus) tumor. 38
12238343 2002
24
[CA19-9 producing mixed gonadal germ-cell tumor in undescended testis located in abdomen. A case report]. 38
8831215 1996
25
[A case of testicular tumor with a small tumor focus in the testis]. 38
8170083 1994
26
[Primary retroperitoneal extra-gonadal germ cell tumor]. 38
8112663 1993
27
The unique association of malignant histiocytosis and a primary gonadal germ cell tumor. 38
1734222 1992
28
Pulmonary nodules simulating metastasis of germ cell tumor after aggressive chemotherapy. 38
2460985 1988

Variations for Gonadal Germ Cell Tumor

Expression for Gonadal Germ Cell Tumor

Search GEO for disease gene expression data for Gonadal Germ Cell Tumor.

Pathways for Gonadal Germ Cell Tumor

GO Terms for Gonadal Germ Cell Tumor

Cellular components related to Gonadal Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.62 CGB5 AFP

Sources for Gonadal Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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