MCID: GND015
MIFTS: 17

Gonadal Germ Cell Tumor

Categories: Rare diseases

Aliases & Classifications for Gonadal Germ Cell Tumor

MalaCards integrated aliases for Gonadal Germ Cell Tumor:

Name: Gonadal Germ Cell Tumor 58

Classifications:



External Ids:

Orphanet 58 ORPHA363582

Summaries for Gonadal Germ Cell Tumor

MalaCards based summary : Gonadal Germ Cell Tumor is related to teratoma and extragonadal germ cell cancer. An important gene associated with Gonadal Germ Cell Tumor is AFP (Alpha Fetoprotein). The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include testis, monocytes and brain.

Related Diseases for Gonadal Germ Cell Tumor

Diseases related to Gonadal Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 teratoma 29.9 CGB5 AFP
2 extragonadal germ cell cancer 29.7 CGB5 AFP
3 nonseminomatous germ cell tumor 29.5 CGB5 AFP
4 seminoma 29.5 CGB5 AFP
5 germinoma 29.4 CGB5 AFP
6 testicular cancer 29.2 CGB5 AFP
7 germ cells tumors 10.5
8 choriocarcinoma 10.3
9 endodermal sinus tumor 10.2
10 testicular yolk sac tumor 10.2
11 spermatogenic failure, x-linked, 1 10.1
12 gonadoblastoma 10.1
13 gonadal dysgenesis 10.1
14 dysgerminoma 10.1
15 mature teratoma 10.1
16 mixed germ cell tumor 10.1
17 leukemia, acute monocytic 10.0
18 pancytopenia 10.0
19 acute leukemia 10.0
20 amenorrhea 10.0
21 azoospermia 10.0
22 hypogonadism 10.0
23 cystic teratoma 10.0
24 germ cell cancer 10.0
25 teratocarcinoma 10.0
26 embryonal carcinoma 10.0
27 histiocytosis 10.0
28 testicular germ cell cancer 10.0
29 embryonal testis carcinoma 10.0
30 hypogonadotropism 10.0
31 monocytic leukemia 10.0
32 malignant histiocytosis 10.0
33 acute monoblastic leukemia 10.0
34 rare tumor 10.0
35 malignant sertoli cell tumor 9.7 CGB5 AFP
36 corpus luteum cyst 9.7 CGB5 AFP
37 adenomatoid tumor 9.7 CGB5 AFP
38 malignant teratoma 9.7 CGB5 AFP
39 gestational trophoblastic neoplasm 9.6 CGB5 AFP
40 anencephaly 9.6 CGB5 AFP
41 ectopic pregnancy 9.6 CGB5 AFP
42 placenta disease 9.5 CGB5 AFP
43 cryptorchidism, unilateral or bilateral 9.4 CGB5 AFP
44 down syndrome 9.2 CGB5 AFP

Graphical network of the top 20 diseases related to Gonadal Germ Cell Tumor:



Diseases related to Gonadal Germ Cell Tumor

Symptoms & Phenotypes for Gonadal Germ Cell Tumor

Drugs & Therapeutics for Gonadal Germ Cell Tumor

Drugs for Gonadal Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Gastrointestinal Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Dermatologic Agents Phase 3
6 Antipruritics Phase 3
7 Histamine H1 Antagonists Phase 3
8 Serotonin Agents Phase 3
9 Histamine Antagonists Phase 3
10
Histamine Phosphate Phase 3 51-74-1 65513
11 Serotonin Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride

Search NIH Clinical Center for Gonadal Germ Cell Tumor

Genetic Tests for Gonadal Germ Cell Tumor

Anatomical Context for Gonadal Germ Cell Tumor

MalaCards organs/tissues related to Gonadal Germ Cell Tumor:

40
Testis, Monocytes, Brain, Ovary, Placenta

Publications for Gonadal Germ Cell Tumor

Articles related to Gonadal Germ Cell Tumor:

(show all 27)
# Title Authors PMID Year
1
Gonadoblastoma-Associated Mixed Gonadal Germ Cell Tumor with Dysgerminoma and Hepatoid Yolk Sac Tumor Components in 46XY Gonadal Dysgenesis. 61
31175959 2019
2
[Transformation of teratoma in rabdomiosarcoma]. 61
30694192 2019
3
Cancer Incidence in Adolescents and Young Adults in 24 Selected Populations of Latin America. 61
29634431 2018
4
Pericardial effusion as an atypical initial presentation of extra-gonadal nonseminomatous germ cell tumor: a case report and literature review. 61
29492268 2018
5
Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru. 61
30018640 2018
6
Mixed Gonadal Germ Cell Tumor Composed of a Spermatocytic Tumor-Like Component and Germinoma Arising in Gonadoblastoma in a Phenotypic Woman With a 46, XX Peripheral Karyotype: Report of the First Case. 61
28614211 2017
7
A practical guide for evaluating gonadal germ cell tumor predisposition in differences of sex development. 61
28544305 2017
8
Atypical presentation of sacrococcygeal yolk sac tumor in infant: beware of the injuries of the gluteal region. 61
27635156 2016
9
Metastatic sacrococcygeal yolk sac tumor: A misleading diagnosis. 61
26167024 2015
10
Vulvar yolk sac tumor diagnosed during pregnancy, with recurrence during subsequent second pregnancy. 61
26076163 2015
11
Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment. 61
25066726 2014
12
[Modified BEP regimen leads to abatement of choriocarcinoma syndrome in a patient with extra gonadal germ cell tumor : a case report]. 61
24882231 2014
13
[A suspected case of extra-gonadal germ cell tumor complicated with choriocarcinoma syndrome]. 61
23719141 2013
14
Androgen insensitivity syndrome. 61
23044881 2012
15
Germ cell tumor of ovary with plenty of sarcoid like granulomas: A diagnosis on fine needle aspiration cytology. 61
23112468 2012
16
[Case of far-advanced retroperitoneal extra-gonadal germ cell tumor responding to intensive treatment including multi-drug chemotherapy with peripheral blood stem cell transplantation and residual tumor removal]. 61
20387517 2010
17
Primary gonadal germ cell tumor associated with acute leukemia with common cytogenetics. 61
19949012 2010
18
[Treatment outcome of children and adolescents with germ cell tumor after combined therapy---a report of 44 cases]. 61
17166380 2006
19
[A non-seminomatous extra-gonadal germ cell tumor responding to intensive treatment: a case report]. 61
16972631 2006
20
Testicular seminoma after the complete remission of extragonadal yolk sac tumor : a case report. 61
15546481 2004
21
Diagnostic significance of soluble c-kit in the cerebrospinal fluid of patients with germ cell tumors. 61
12134909 2002
22
Malignant sacrococcygeal yolk sac (endodermal sinus) tumor. 61
12238343 2002
23
[CA19-9 producing mixed gonadal germ-cell tumor in undescended testis located in abdomen. A case report]. 61
8831215 1996
24
[A case of testicular tumor with a small tumor focus in the testis]. 61
8170083 1994
25
[Primary retroperitoneal extra-gonadal germ cell tumor]. 61
8112663 1993
26
The unique association of malignant histiocytosis and a primary gonadal germ cell tumor. 61
1734222 1992
27
Pulmonary nodules simulating metastasis of germ cell tumor after aggressive chemotherapy. 61
2460985 1988

Variations for Gonadal Germ Cell Tumor

Expression for Gonadal Germ Cell Tumor

Search GEO for disease gene expression data for Gonadal Germ Cell Tumor.

Pathways for Gonadal Germ Cell Tumor

GO Terms for Gonadal Germ Cell Tumor

Sources for Gonadal Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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