MCID: GNC007
MIFTS: 15

Gonococcal Keratitis

Categories: Eye diseases

Aliases & Classifications for Gonococcal Keratitis

MalaCards integrated aliases for Gonococcal Keratitis:

Name: Gonococcal Keratitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9697
ICD9CM 34 098.43
SNOMED-CT 67 40149008
ICD10 32 A54.33
UMLS 71 C0153214

Summaries for Gonococcal Keratitis

MalaCards based summary : Gonococcal Keratitis is related to keratitis, hereditary and lung squamous cell carcinoma. An important gene associated with Gonococcal Keratitis is FBXO7 (F-Box Protein 7). Affiliated tissues include eye, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Gonococcal Keratitis

Diseases related to Gonococcal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.0
2 lung squamous cell carcinoma 9.5 PLK1 ALK
3 leukemia, chronic myeloid 9.4 PLK1 ALK
4 lymphoma, non-hodgkin, familial 9.2 PLK1 ALK

Symptoms & Phenotypes for Gonococcal Keratitis

GenomeRNAi Phenotypes related to Gonococcal Keratitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.35 PLK1
2 Decreased substrate adherent cell growth GR00193-A-2 9.35 ALK PLK1
3 Decreased substrate adherent cell growth GR00193-A-3 9.35 PLK1
4 Decreased substrate adherent cell growth GR00193-A-4 9.35 PLK1
5 Decreased cell migration GR00055-A-1 9.26 ALK PLK1
6 Decreased cell proliferation GR00353-A 9.16 ALK PLK1
7 Misorientated spindle GR00256-A 8.62 ALK PLK1

Drugs & Therapeutics for Gonococcal Keratitis

Search Clinical Trials , NIH Clinical Center for Gonococcal Keratitis

Genetic Tests for Gonococcal Keratitis

Anatomical Context for Gonococcal Keratitis

MalaCards organs/tissues related to Gonococcal Keratitis:

40
Eye

Publications for Gonococcal Keratitis

Articles related to Gonococcal Keratitis:

# Title Authors PMID Year
1
Challenges in the management of Neisseria gonorrhoeae keratitis. 61
25544662 2015
2
Recent trends in chlamydial and gonococcal conjunctivitis among neonates and adults in an Irish hospital. 61
18093859 2008
3
Deep anterior lamellar keratoplasty in a patient with descemetocele following gonococcal keratitis. 61
15364250 2004

Variations for Gonococcal Keratitis

Expression for Gonococcal Keratitis

Search GEO for disease gene expression data for Gonococcal Keratitis.

Pathways for Gonococcal Keratitis

GO Terms for Gonococcal Keratitis

Biological processes related to Gonococcal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin-dependent protein catabolic process GO:0006511 8.96 PLK1 FBXO7
2 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 8.62 PLK1 FBXO7

Molecular functions related to Gonococcal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 8.62 PLK1 FBXO7

Sources for Gonococcal Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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