MCID: GDP001
MIFTS: 55

Goodpasture Syndrome

Categories: Bone diseases, Cardiovascular diseases, Immune diseases, Nephrological diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Goodpasture Syndrome

MalaCards integrated aliases for Goodpasture Syndrome:

Name: Goodpasture Syndrome 56 12 52 58 54 15 17
Anti-Glomerular Basement Membrane Disease 12 58 43 71
Pulmonary Renal Syndrome 52 71
Anti-Gbm Disease 12 54
Rapidly Progressive Glomerulonephritis with Pulmonary Hemorrhage 52
Anti-Glomerular Basement Membrane Antibody Disease 52
Anti-Glomerular Basement Membrane Disease 36
Anti-Basement Membrane Glomerulonephritis 71
Glomerulonephritis - Pulmonary Hemorrhage 52
Goodpasture's Syndrome 74
Anti-Gbm Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
anti-glomerular basement membrane disease
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult;

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
goodpasture syndrome:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare circulatory system diseases
Rare renal diseases
Rare respiratory diseases
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 12 DOID:9808
OMIM 56 233450
KEGG 36 H01721
ICD9CM 34 446.21
MeSH 43 D019867
NCIt 49 C84566
SNOMED-CT 67 236506009
ICD10 32 M31.0
ICD10 via Orphanet 33 M31.0+ N08.5*
UMLS via Orphanet 72 C0403529
Orphanet 58 ORPHA375
MedGen 41 C0403529
UMLS 71 C0403529 C0549143 C1332309

Summaries for Goodpasture Syndrome

NIH Rare Diseases : 52 Goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis . Some use the term "Goodpasture syndrome" for the findings of glomerulonephritis and pulmonary hemorrhage and the term "Goodpasture disease" for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-GBM antibodies . Currently, the preferred term for both conditions is "anti-GBM antibody disease ". Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage). Symptoms may include general body discomfort or pain, bleeding from the nose and/or blood in the urine, respiratory problems, anemia , chest pain, and kidney failure. Anti-GBM disease is thought to result from an environmental insult (smoking, infections, exposure to certain drugs) in a person with genetic susceptibility , such as a specific human leukocyte antigen (HLA) type. Diagnosis is confirmed with the presence of anti-GBM antibody in the blood or in the kidney. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide.

MalaCards based summary : Goodpasture Syndrome, also known as anti-glomerular basement membrane disease, is related to anti-basement membrane glomerulonephritis and crescentic glomerulonephritis. An important gene associated with Goodpasture Syndrome is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and Tuberculosis. The drugs Sodium citrate and Citric acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and testes, and related phenotypes are proteinuria and anemia

Disease Ontology : 12 An autoimmune hypersensitivity disease that is characterized by antibody attack of the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.

KEGG : 36 Goodpasture syndrome (GS), or anti-glomerular basement membrane (anti-GBM) disease, is a rare and organ-specific autoimmune disease defined by anti-GBM antibody-mediated damage (mainly immunoglobulin G-1) resulting in progressive crescentic glomerulonephritis and, frequently, diffuse pulmonary alveolar hemorrhage. Clinically, GS is characterized by pulmonary hemorrhage and renal failure, although the clinical spectrum may range from only mild symptoms to a relentless and finally lethal outcome. This disease accounts for 10-20% of the patients with acute renal failure following a rapidly progressive glomerulonephritis. The disease is caused by an autoimmune response against the non-collagenase domain of the alpha 3 chain of type IV collagen [alpha3(IV)NC1], found in the glomerular and alveolar basement membranes. Without prompt diagnosis and treatment, the disease can lead to bleeding in the lungs, kidney failure, and even death. Early and intensive treatment with plasmapheresis and immunosuppression with systemic corticosteroids pending results of diagnostic testing, and later cyclophosphamide, is often beneficial, with 90% of patients surviving the acute presentation of GS.

Wikipedia : 74 Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare... more...

More information from OMIM: 233450

Related Diseases for Goodpasture Syndrome

Diseases related to Goodpasture Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 506)
# Related Disease Score Top Affiliating Genes
1 anti-basement membrane glomerulonephritis 31.2 PRTN3 MPO COL4A5 COL4A4 COL4A3 CD4
2 crescentic glomerulonephritis 30.9 VCAM1 PRTN3 MPO
3 rapidly progressive glomerulonephritis 30.7 PRTN3 PLA2R1 NPHS1 MPO COL4A4 COL4A3
4 vasculitis 30.7 VCAM1 PRTN3 MPO CD40LG
5 anca-associated vasculitis 30.6 PRTN3 MPO
6 alport syndrome 1, x-linked 30.6 COL4A5 COL4A4
7 x-linked alport syndrome 30.5 NID1 COL4A5 COL4A4 COL4A3
8 alport syndrome 2, autosomal recessive 30.4 COL4A4 COL4A3
9 interstitial nephritis 30.4 CD40LG CCR6 ALB
10 pulmonary hemosiderosis 30.4 PRTN3 MPO
11 primary progressive multiple sclerosis 30.3 VCAM1 HLA-DRB1 CCR6
12 collagen disease 30.3 H2AC18 CD40LG CCR6
13 relapsing-remitting multiple sclerosis 30.3 HLA-DRB1 CD52 CD40LG CCR6
14 autoimmune glomerulonephritis 30.3 FCGR2B COL4A3 CD4 CCR6
15 hematuria, benign familial 30.2 COL4A5 COL4A4 COL4A3
16 polyarteritis nodosa 30.2 VCAM1 PRTN3 MPO HLA-DRB1
17 autoimmune vasculitis 30.2 PRTN3 MPO CD4 CCR6
18 churg-strauss syndrome 30.2 PRTN3 MPO HLA-DRB1 CD40LG
19 microscopic polyangiitis 30.1 MPO HLA-DRB1 FCGR2A
20 extrinsic allergic alveolitis 30.1 MPO CCR6 ALB
21 splenic infarction 30.1 PRTN3 CD40LG ALB
22 alport syndrome 30.1 COL4A5 COL4A4 COL4A3 ALB
23 endocarditis 30.1 VCAM1 FCGR2A ALB
24 common variable immunodeficiency 30.0 MPO HLA-DRB1 FCGR2B CD40LG
25 meningoencephalitis 29.9 CD40LG CD4 CCR6 ALB
26 glomerular disease 29.8 NPHS1 ALB
27 drug-induced lupus erythematosus 29.8 H2AC18 CD4 ALB
28 allergic hypersensitivity disease 29.8 VCAM1 H2AC18 CD4 CCR6
29 drug allergy 29.7 CD40LG CD4 ALB
30 systemic scleroderma 29.7 H2AC18 CD40LG CD4 CCR6
31 nail-patella syndrome 29.7 NPHS1 COL4A4 COL4A3
32 bacterial pneumonia 29.6 H2AC18 CD40LG CD4 CCR6 ALB
33 primary biliary cirrhosis 29.6 PRTN3 HLA-DRB1 CD40LG CD4 ALB
34 autoimmune disease 29.6 VCAM1 PRTN3 HLA-DRB1 FCGR2B FCGR2A CD40LG
35 respiratory failure 29.6 MPO H2AC18 CD40LG CD4 CCR6 ALB
36 granulomatosis with polyangiitis 29.5 PRTN3 MPO CD40LG CD4 CCR6
37 pancytopenia 29.5 MPO CD40LG CD4 ALB
38 central nervous system vasculitis 29.5 PRTN3 MPO HLA-DRB1 CD40LG CD4 CCR6
39 hantavirus hemorrhagic fever with renal syndrome 29.4 CD40LG CD4 ALB
40 peripheral nervous system disease 29.4 PRTN3 H2AC18 CD40LG CD4 CCR6 ALB
41 membranous nephropathy 29.3 PLA2R1 NPHS1 MPO ALB
42 end stage renal disease 29.3 NPHS1 COL4A5 COL4A4 COL4A3 ALB
43 sarcoidosis 1 29.3 HLA-DRB1 CD40LG CD4 CCR6
44 henoch-schoenlein purpura 29.3 VCAM1 PRTN3 MPO CD40LG ALB
45 vascular disease 29.3 VCAM1 MPO CD40LG CD4 ALB
46 takayasu arteritis 29.3 VCAM1 HLA-DRB1 FCGR2A CD40LG
47 pharyngitis 29.3 HLA-DRB1 CD40LG CD4 ALB
48 chickenpox 29.2 CD40LG CD4 CCR6 ALB
49 immune-complex glomerulonephritis 29.2 VCAM1 MPO H2AC18 CD40LG CD4 ALB
50 exanthem 29.1 PRTN3 MPO H2AC18 CD40LG CD4 CCR6

Comorbidity relations with Goodpasture Syndrome via Phenotypic Disease Network (PDN):


Acute Kidney Failure Deficiency Anemia
Heart Disease Respiratory Failure

Graphical network of the top 20 diseases related to Goodpasture Syndrome:



Diseases related to Goodpasture Syndrome

Symptoms & Phenotypes for Goodpasture Syndrome

Human phenotypes related to Goodpasture Syndrome:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 proteinuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000093
2 anemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001903
3 pulmonary infiltrates 58 31 hallmark (90%) Very frequent (99-80%) HP:0002113
4 autoimmunity 58 31 hallmark (90%) Very frequent (99-80%) HP:0002960
5 cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0012735
6 chest pain 58 31 hallmark (90%) Very frequent (99-80%) HP:0100749
7 respiratory insufficiency 58 31 hallmark (90%) Very frequent (99-80%) HP:0002093
8 glomerulopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0100820
9 hemoptysis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002105
10 vasculitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0002633
11 persistence of primary teeth 58 31 hallmark (90%) Very frequent (99-80%) HP:0006335
12 hematuria 58 31 frequent (33%) Frequent (79-30%) HP:0000790
13 arthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001369
14 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
15 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
16 arthralgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002829
17 myalgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003326
18 retinal detachment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000541
19 purpura 58 31 occasional (7.5%) Occasional (29-5%) HP:0000979
20 dyspnea 31 HP:0002094
21 glomerulonephritis 31 HP:0000099
22 pulmonary hemorrhage 31 HP:0040223

Symptoms via clinical synopsis from OMIM:

56
Laboratory Abnormalities:
proteinuria
hematuria
circulating antibodies to alpha-3 chain of type iv collagen

Respiratory:
dyspnea

Immunology:
autoimmune disease

Genitourinary Kidneys:
renal insufficiency
glomerulonephritis

Respiratory Lung:
pulmonary infiltrates
hemoptysis
pulmonary hemorrhage

Clinical features from OMIM:

233450

GenomeRNAi Phenotypes related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB CCR6 CD52 COL4A5 FCGR2A PRTN3

MGI Mouse Phenotypes related to Goodpasture Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ALB CCR6 CD40LG CERT1 COL4A3 COL4A5
2 immune system MP:0005387 9.8 ALB CCR6 CD4 CD40LG COL4A3 COL4A4
3 mortality/aging MP:0010768 9.44 ALB CD4 CD40LG CERT1 COL4A3 COL4A4

Drugs & Therapeutics for Goodpasture Syndrome

Drugs for Goodpasture Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sodium citrate Approved, Investigational 68-04-2
2
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
3 Immunologic Factors
4 Antibodies
5 Immunoglobulins, Intravenous
6 Immunoglobulin G
7 Immunoglobulins
8 Autoantibodies
9 Citrate
10 Hemostatics
11 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Immunoadsorption in Anti-glomerular Basement Membrane Glomerulonephritis; a Pilot Study Recruiting NCT02765789 Phase 4
2 An Open-Label Phase II Study in Anti-GBM Disease (Goodpasture's Disease) With Adverse Renal Prognosis to Evaluate the Efficacy and Safety of IdeS --GOOD-IDES Unknown status NCT03157037 Phase 2
3 Immune Ablation and Hematopoietic Stem Cell Support in Patients With Poor Prognostic Indicators and Systemic Lupus Erythematosus:A Phase II Study Completed NCT00271934 Phase 2
4 Detection of Anti-glomerular Basement Membrane Antibodies (Anti-GBM): a Promising Biomarker for Lupus Nephritis (LN) Screening in Systemic Lupus Erythematosus (SLE) Patients? Completed NCT03664908
5 Comparison of ANCA and Anti-GBM Auto-antibodies Removal Kinetics Between Plasma Exchanges and Immunoadsorption in Patients With ANCA-associated Vasculitis or Anti-GBM Disease Recruiting NCT03635385
6 A Prospective Interventional Study to Investigate Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation With or Without Coagulation Factors Replacement Recruiting NCT03801135 Fibrinogen concentrate
7 Multicentre, Randomized, Double-blind, Prospective Investigation on the Effects of Immunoadsorption on Cardiac Function in Patients With Dilated Cardiomyopathy Recruiting NCT00558584

Search NIH Clinical Center for Goodpasture Syndrome

Cochrane evidence based reviews: anti-glomerular basement membrane disease

Genetic Tests for Goodpasture Syndrome

Anatomical Context for Goodpasture Syndrome

MalaCards organs/tissues related to Goodpasture Syndrome:

40
Kidney, Lung, Testes, Neutrophil, T Cells, Bone, Monocytes

Publications for Goodpasture Syndrome

Articles related to Goodpasture Syndrome:

(show top 50) (show all 475)
# Title Authors PMID Year
1
Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. 56 61
9410904 1997
2
Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen. 56 61
1737849 1992
3
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. 56
28467828 2017
4
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. 56
20660402 2010
5
Alport's syndrome, Goodpasture's syndrome, and type IV collagen. 56
12815141 2003
6
Goodpasture's syndrome in twins. 56
7158437 1982
7
Goodpasture's syndrome in identical twins. 56
563692 1978
8
Goodpasture's syndrome: a familial occurrence. 56
5017886 1972
9
Antineutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in a patient with anti-glomerular basement membrane disease. 61 54
7651563 1995
10
Prognostic implication of anti-neutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease. 61 54
1657470 1991
11
A rare case of Goodpasture syndrome concomitant with bleeding jejunal Dieulafoy's lesion. 61
31786734 2020
12
Benefit of Howell-Jolly bodies detection: finding of an acquired hyposplenism in a patient with Goodpasture syndrome. 61
32319948 2020
13
Anti-glomerular basement membrane disease complicated with posterior reversible encephalopathy syndrome and subcortical cerebral hemorrhage: a case report and review of the literature. 61
32277358 2020
14
Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases. 61
32317520 2020
15
Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings. 61
32296530 2020
16
Severe Infection in Anti-Glomerular Basement Membrane Disease: A Retrospective Multicenter French Study. 61
32143501 2020
17
Atypical Anti-Glomerular Basement Membrane Disease With Diffuse Crescentic Membranoproliferative Glomerulonephritis: Case Report and Review of Literature. 61
32391252 2020
18
[Review on anti-glomerular basement membrane disease or Goodpasture's syndrome]. 61
31776042 2020
19
Goodpasture syndrome and hemorrhage after renal biopsy: A case report. 61
32047792 2020
20
A new mouse model of anti-GBM disease sheds light on maternal transfer of alloantibodies in glomerular disease. 61
31759484 2019
21
Maternal alloimmune IgG causes anti-glomerular basement membrane disease in perinatal transgenic mice that express human laminin α5. 61
31530475 2019
22
Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise. 61
31807293 2019
23
Odd combinations-coexistence of anti-glomerular basement membrane disease and Sjögren's syndrome. 61
31170292 2019
24
Anti-glomerular basement membrane disease: an update on subgroups, pathogenesis and therapies. 61
30371823 2019
25
IdeS in anti-glomerular basement membrane disease: Is this the new deal? 61
31648697 2019
26
Plasma exchange in anti-glomerular basement membrane disease. 61
31703956 2019
27
The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease. 61
31563334 2019
28
Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases. 61
30692587 2019
29
Recurrent anti-GBM disease with T-cell large granular lymphocytic leukemia: A case report. 61
31374037 2019
30
Therapeutic apheresis in neurological, nephrological and gastrointestinal diseases. 61
31029610 2019
31
Acute Thrombotic Microangiopathy and Cortical Necrosis Following Administration of Alemtuzumab: A Case Report. 61
30528935 2019
32
[Rapid progressive glomerulonephritis]. 61
30868251 2019
33
A rare fatal complication of bleeding immediately following polytetrafluoroethylene arteriovenous grafting in a lady with Goodpasture syndrome. 61
30253034 2019
34
Anti-glomerular basement membrane disease due to monoclonal IgG Lambda antibodies: a very rare case of monoclonal gammopathy of renal significance. 61
30302532 2019
35
Rituximab for Anti-Glomerular Basement Membrane Disease. 61
30993238 2019
36
[Recurrence of goodpasture syndrome with negative antiglomerular basement antibodies. Report of one case]. 61
31344179 2019
37
Chemokine Receptor 8 Can Distinguish Antineutrophil Cytoplasmic Antibody-Associated Vasculitis From Infectious Complications. 61
30899872 2019
38
A Case of Anti-glomerular Basement Disease Without Pulmonary Involvement. 61
31058013 2019
39
Binding Truths: Atypical Anti-Glomerular Basement Membrane Disease Mediated by IgA Anti-Glomerular Basement Membrane Antibodies Targeting the α1 Chain of Type IV Collagen. 61
30596180 2019
40
A case of bizarre posttransplant anti-glomerular basement membrane disease. 61
31530992 2019
41
Prognostic Factors in Anti-glomerular Basement Membrane Disease: A Multicenter Study of 119 Patients. 61
31396214 2019
42
Clinicopathological features and outcome of antibody-negative anti-glomerular basement membrane disease. 61
30315136 2019
43
What triggered massive hemoptysis in Goodpasture syndrome with isolated pulmonary involvement in a 14-year-old boy? 61
31990483 2019
44
Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage. 61
31178913 2019
45
Recurrence of Goodpasture syndrome without circulating anti-glomerular basement membrane antibodies after kidney transplant, a case report. 61
30621605 2019
46
End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency. 61
30838168 2019
47
Cyclophosphamide pulse therapy as treatment for severe interstitial lung diseases. 61
32476949 2019
48
Cutaneous vasculitis preceding the onset of anti-GBM disease (Goodpasture syndrome). 61
30545692 2019
49
Severe acute respiratory failure due to Sai-rei-to-induced lung injury successfully treated by multi-modal therapy including immunosuppressive therapy, plasma exchange, and intravenous immunoglobulin: A case report. 61
31709142 2019
50
Extracellular traps in kidney disease. 61
30466565 2018

Variations for Goodpasture Syndrome

Expression for Goodpasture Syndrome

Search GEO for disease gene expression data for Goodpasture Syndrome.

Pathways for Goodpasture Syndrome

GO Terms for Goodpasture Syndrome

Cellular components related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.15 VCAM1 PXDN PRTN3 NPHS1 NID1 MPO
2 integral component of plasma membrane GO:0005887 10.06 VCAM1 NPHS1 HLA-DRB1 FCGR2B FCGR2A CD40LG
3 extracellular region GO:0005576 10.06 PXDN PRTN3 PLA2R1 NID1 MPO COL4A5
4 cell surface GO:0009986 9.95 VCAM1 PLA2R1 HLA-DRB1 CD40LG CD4 CCR6
5 extracellular space GO:0005615 9.85 VCAM1 PXDN PRTN3 MPO HLA-DRB1 COL4A5
6 endoplasmic reticulum lumen GO:0005788 9.83 COL4A5 COL4A4 COL4A3 CD4 ALB
7 external side of plasma membrane GO:0009897 9.73 VCAM1 HLA-DRB1 FCGR2B CD40LG CD4 CCR6
8 basement membrane GO:0005604 9.71 NID1 COL4A5 COL4A4 COL4A3
9 collagen trimer GO:0005581 9.67 COL4A5 COL4A4 COL4A3 CERT1
10 collagen-containing extracellular matrix GO:0062023 9.43 PXDN PRTN3 NID1 COL4A5 COL4A4 COL4A3
11 collagen type IV trimer GO:0005587 8.8 COL4A5 COL4A4 COL4A3

Biological processes related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.7 PXDN HLA-DRB1 FCGR2B CERT1 CD40LG CD4
2 regulation of immune response GO:0050776 9.67 VCAM1 FCGR2B FCGR2A CD40LG
3 cellular oxidant detoxification GO:0098869 9.61 PXDN MPO ALB
4 positive regulation of T cell proliferation GO:0042102 9.5 VCAM1 CD40LG CD4
5 positive regulation of monocyte differentiation GO:0045657 9.46 HLA-DRB1 CD4
6 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.43 COL4A5 COL4A4 COL4A3
7 extracellular matrix organization GO:0030198 9.43 VCAM1 PXDN NID1 COL4A5 COL4A4 COL4A3
8 positive regulation of viral entry into host cell GO:0046598 9.4 HLA-DRB1 CD4
9 glomerular basement membrane development GO:0032836 8.92 NPHS1 NID1 COL4A4 COL4A3

Molecular functions related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 9.16 FCGR2B FCGR2A
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL4A5 COL4A4 COL4A3
3 extracellular matrix structural constituent GO:0005201 9.1 PXDN NID1 COL4A5 COL4A4 COL4A3 CD4

Sources for Goodpasture Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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