Goodpasture Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GDP001 MIFTS: 55	Goodpasture Syndrome Categories: Bone diseases, Cardiovascular diseases, Immune diseases, Nephrological diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Goodpasture Syndrome

MalaCards integrated aliases for Goodpasture Syndrome:

Name: Goodpasture Syndrome ⁵⁷ ¹² ²⁰ ⁵⁸ ⁵⁴ ¹⁵ ¹⁷

Anti-Glomerular Basement Membrane Disease ¹² ⁵⁸ ⁴⁴ ⁷¹

Pulmonary Renal Syndrome ²⁰ ⁷¹

Anti-Gbm Disease ¹² ⁵⁴

Rapidly Progressive Glomerulonephritis with Pulmonary Hemorrhage ²⁰

Anti-Glomerular Basement Membrane Antibody Disease ²⁰

Anti-Glomerular Basement Membrane Disease ³⁶

Anti-Basement Membrane Glomerulonephritis ⁷¹

Glomerulonephritis - Pulmonary Hemorrhage ²⁰

Goodpasture's Syndrome ⁷⁴

Anti-Gbm Syndrome ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

anti-glomerular basement membrane disease
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult;

OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Inheritance:
autosomal recessive

HPO:

³¹

goodpasture syndrome:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Nephrological diseases Respiratory diseases Bone diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the musculoskeletal system and connective tissue

Systemic connective tissue disorders

Other necrotizing vasculopathies

Hypersensitivity angiitis

Orphanet: ⁵⁸

Rare circulatory system diseases

Rare renal diseases

Rare respiratory diseases

Rare systemic and rhumatological diseases

External Ids:

Disease Ontology ¹² DOID:9808

OMIM® ⁵⁷ 233450

KEGG ³⁶ H01721

ICD9CM ³⁴ 446.21

MeSH ⁴⁴ D019867

NCIt ⁵⁰ C84566

SNOMED-CT ⁶⁷ 788613004

ICD10 ³² M31.0

ICD10 via Orphanet ³³ M31.0+ N08.5*

UMLS via Orphanet ⁷² C0403529

Orphanet ⁵⁸ ORPHA375

MedGen ⁴¹ C0403529

EFO ¹⁷ EFO_0007290

UMLS ⁷¹ C0403529 C0549143 C1332309

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Summaries for Goodpasture Syndrome

GARD : ²⁰ Goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis. Some use the term "Goodpasture syndrome" for the findings of glomerulonephritis and pulmonary hemorrhage and the term "Goodpasture disease" for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-GBM antibodies. Currently, the preferred term for both conditions is "anti-GBM antibody disease". Circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (GBM), resulting in acute or rapidly progressive glomerulonephritis. Antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage). Symptoms may include general body discomfort or pain, bleeding from the nose and/or blood in the urine, respiratory problems, anemia, chest pain, and kidney failure. Anti-GBM disease is thought to result from an environmental insult (smoking, infections, exposure to certain drugs) in a person with genetic susceptibility, such as a specific human leukocyte antigen (HLA) type. Diagnosis is confirmed with the presence of anti-GBM antibody in the blood or in the kidney. The treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide.

MalaCards based summary : Goodpasture Syndrome, also known as anti-glomerular basement membrane disease, is related to crescentic glomerulonephritis and x-linked alport syndrome. An important gene associated with Goodpasture Syndrome is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are Degradation of the extracellular matrix and Tuberculosis. The drugs Immunologic Factors and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and neutrophil, and related phenotypes are respiratory insufficiency and proteinuria

Disease Ontology : ¹² An autoimmune disease that is characterized by antibody attack of the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure.

KEGG : ³⁶ Goodpasture syndrome (GS), or anti-glomerular basement membrane (anti-GBM) disease, is a rare and organ-specific autoimmune disease defined by anti-GBM antibody-mediated damage (mainly immunoglobulin G-1) resulting in progressive crescentic glomerulonephritis and, frequently, diffuse pulmonary alveolar hemorrhage. Clinically, GS is characterized by pulmonary hemorrhage and renal failure, although the clinical spectrum may range from only mild symptoms to a relentless and finally lethal outcome. This disease accounts for 10-20% of the patients with acute renal failure following a rapidly progressive glomerulonephritis. The disease is caused by an autoimmune response against the non-collagenase domain of the alpha 3 chain of type IV collagen [alpha3(IV)NC1], found in the glomerular and alveolar basement membranes. Without prompt diagnosis and treatment, the disease can lead to bleeding in the lungs, kidney failure, and even death. Early and intensive treatment with plasmapheresis and immunosuppression with systemic corticosteroids pending results of diagnostic testing, and later cyclophosphamide, is often beneficial, with 90% of patients surviving the acute presentation of GS.

Wikipedia : ⁷⁴ Goodpasture syndrome (GPS), also known as anti-glomerular basement membrane disease, is a rare... more...

More information from OMIM: 233450

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Related Diseases for Goodpasture Syndrome

Diseases related to Goodpasture Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 436)

#	Related Disease	Score	Top Affiliating Genes
1	crescentic glomerulonephritis	30.7	VCAM1 PRTN3 MPO
2	x-linked alport syndrome	30.6	COL4A5 COL4A4 COL4A3
3	pulmonary hemosiderosis	30.5	PRTN3 MPO
4	diffuse cutaneous systemic sclerosis	30.3	HLA-DRB1 CCR6
5	autoimmune glomerulonephritis	30.3	FCGR2B COL4A3 CD4 CCR6
6	anca-associated vasculitis	30.3	PRTN3 MPO
7	rapidly progressive glomerulonephritis	30.2	PRTN3 PLA2R1 NPHS1 MPO COL4A4 COL4A3
8	churg-strauss syndrome	30.2	PRTN3 MPO HLA-DRB1
9	autoimmune vasculitis	30.2	PRTN3 MPO CD4 CCR6
10	meningoencephalitis	30.2	CD4 CCR6 ALB
11	alport syndrome 1, x-linked	30.2	COL4A5 COL4A4
12	bacterial pneumonia	30.1	H2AC18 CD4 CCR6 ALB
13	polyarteritis nodosa	30.1	VCAM1 PRTN3 MPO HLA-DRB1
14	extrinsic allergic alveolitis	30.0	MPO CCR6 ALB
15	drug-induced lupus erythematosus	30.0	H2AC18 CD4 ALB
16	inner ear disease	29.9	MPO COL4A5 COL4A4
17	respiratory failure	29.9	MPO H2AC18 CD4 CCR6 ALB
18	exanthem	29.9	PRTN3 H2AC18 CD4 CCR6 ALB
19	endocarditis	29.9	VCAM1 FCGR2A ALB
20	anti-basement membrane glomerulonephritis	29.9	PRTN3 MPO FCGR2B COL4A5 COL4A4 COL4A3
21	autoimmune disease	29.9	VCAM1 PRTN3 MPO HLA-DRB1 FCGR2B FCGR2A
22	central nervous system vasculitis	29.8	PRTN3 MPO HLA-DRB1 CD4 CCR6
23	henoch-schoenlein purpura	29.8	VCAM1 PRTN3 MPO ALB
24	hematuria, benign familial	29.8	COL4A5 COL4A4 COL4A3 ALB
25	granulomatosis with polyangiitis	29.8	PRTN3 MPO CD4 CCR6
26	membranoproliferative glomerulonephritis	29.7	NPHS1 CFP ALB
27	primary biliary cholangitis	29.7	PRTN3 HLA-DRB1 H2AC18 CD4 CCR6 ALB
28	takayasu arteritis	29.7	VCAM1 HLA-DRB1 FCGR2A
29	end stage renal disease	29.7	NPHS1 COL4A5 COL4A4 COL4A3 ALB
30	chickenpox	29.7	CD4 CCR6 ALB
31	microscopic polyangiitis	29.7	MPO HLA-DRB1 FCGR2B FCGR2A
32	nail-patella syndrome	29.6	NPHS1 COL4A4 COL4A3
33	multiple sclerosis	29.6	VCAM1 HLA-DRB1 CD52 CD4 CCR6 ALB
34	immune-complex glomerulonephritis	29.5	VCAM1 MPO H2AC18 CD4 ALB
35	membranous nephropathy	29.4	PLA2R1 NPHS1 MPO ALB
36	connective tissue disease	29.4	HLA-DRB1 H2AC18 CD4 CCR6 ALB
37	eye disease	29.3	VCAM1 H2AC18 CD4 CCR6 ALB
38	glomerulonephritis	29.2	VCAM1 PRTN3 NPHS1 NID1 MPO COL4A5
39	proteinuria, chronic benign	29.2	NPHS1 COL4A5 COL4A4 COL4A3 ALB
40	kidney disease	29.2	VCAM1 PRTN3 NPHS1 COL4A5 COL4A4 COL4A3
41	iga glomerulonephritis	29.2	PRTN3 NPHS1 CFP CCR6 ALB
42	bacterial infectious disease	29.0	H2AC18 FCGR2A CFP CD4 CCR6
43	disease by infectious agent	28.8	PRTN3 H2AC18 FCGR2A CD4 CCR6 ALB
44	chronic kidney disease	28.8	VCAM1 NPHS1 MPO COL4A5 COL4A4 COL4A3
45	alport syndrome	28.7	NPHS1 NID1 HLA-DRB1 COL4A5 COL4A4 COL4A3
46	rheumatoid arthritis	28.6	VCAM1 PRTN3 MPO HLA-DRB1 FCGR2B FCGR2A
47	systemic lupus erythematosus	28.5	VCAM1 PRTN3 MPO HLA-DRB1 H2AC18 FCGR2B
48	purulent acute otitis media	10.4	PRTN3 MPO
49	allergic cutaneous vasculitis	10.4	PRTN3 MPO
50	hypertensive encephalopathy	10.4

Comorbidity relations with Goodpasture Syndrome via Phenotypic Disease Network (PDN):

Acute Kidney Failure	Deficiency Anemia
Heart Disease	Respiratory Failure

Graphical network of the top 20 diseases related to Goodpasture Syndrome:

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Symptoms & Phenotypes for Goodpasture Syndrome

Human phenotypes related to Goodpasture Syndrome:

⁵⁸ ³¹ (show all 24)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	respiratory insufficiency ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002093
2	proteinuria ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000093
3	anemia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001903
4	autoimmunity ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002960
5	glomerulopathy ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0100820
6	hemoptysis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002105
7	cough ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0012735
8	chest pain ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0100749
9	vasculitis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002633
10	pulmonary infiltrates ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002113
11	persistence of primary teeth ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0006335
12	hematuria ⁵⁸ ³¹	frequent (33%)	Frequent (79-30%)	HP:0000790
13	arthritis ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001369
14	renal insufficiency ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000083
15	fever ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0001945
16	arthralgia ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0002829
17	myalgia ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0003326
18	retinal detachment ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000541
19	purpura ⁵⁸ ³¹	occasional (7.5%)	Occasional (29-5%)	HP:0000979
20	pulmonary hemorrhage ³¹	very rare (1%)		HP:0040223
21	cytoplasmic antineutrophil antibody positivity ³¹	very rare (1%)		HP:0032230
22	dyspnea ³¹			HP:0002094
23	glomerulonephritis ³¹			HP:0000099
24	anti-glomerular basement membrane-antibody positivity ³¹			HP:0033030

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Mar-2021)

Laboratory Abnormalities:
proteinuria
hematuria
circulating antibodies to alpha-3 chain of type iv collagen

Respiratory:
dyspnea

Immunology:
autoimmune disease

Genitourinary Kidneys:
renal insufficiency
glomerulonephritis

Respiratory Lung:
hemoptysis
pulmonary infiltrates
pulmonary hemorrhage

Clinical features from OMIM®:

233450 (Updated 05-Mar-2021)

GenomeRNAi Phenotypes related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.17	ALB CCR6 CD52 COL4A5 FCGR2A PRTN3

MGI Mouse Phenotypes related to Goodpasture Syndrome:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.47	ALB CCR6 CD4 CFP COL4A3 COL4A4

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Drugs & Therapeutics for Goodpasture Syndrome

Drugs for Goodpasture Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Immunologic Factors

Phase 2

Immunoglobulin G

Phase 2

Immunoglobulins, Intravenous

Phase 2

Sodium citrate

Approved, Investigational

68-04-2

Synonyms:

Anhydrous sodium citrate

Anhydrous trisodium citrate

Citric acid, trisodium salt

Natrii citras

Natrocitral

Sodium citrate anhydrous

Sodium citrate, anhydrous

Sodium citrate,anhydrous

trisodium citrate anhydrous

Trisodium citrate, anhydrous

Trisodium-citrate

Citric acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

Synonyms:

2-hydroxy-1,2,3-propanetricarboxyic acid

2-Hydroxy-1,2,3-propanetricarboxylate

2-Hydroxy-1,2,3-propanetricarboxylic acid

2-Hydroxytricarballylate

2-Hydroxytricarballylic acid

3-Carboxy-3-hydroxypentane-1,5-dioate

3-carboxy-3-hydroxypentane-1,5-dioic acid

3-Carboxy-3-hydroxypentane-1,5-dioic acid

Acid monohydrate, citric

ácido cítrico

Acidum citricum

Aciletten

Anhydrous citrate

Anhydrous citric acid

beta-Hydroxytricarballylate

beta-Hydroxytricarballylic acid

Chemfill

Citraclean

Citrate

Citrate anhydrous

Citretten

Citric acid anhydrous

Citric acid monoglyceride

Citric acid monohydrate

Citric acid, anhydrous

Citric acid,anhydrous

Citro

Citronensaeure

Citronensäure

e 330

e330

H3Cit

Hydrocerol a

Kyselina citronova

Monohydrate, citric acid

Suby g

Uralyt u

Uro-trainer

Hemostatics

Pharmaceutical Solutions

Citrate

Immunoglobulins

Antibodies

Autoantibodies

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open-Label Phase II Study in Anti-GBM Disease (Goodpasture's Disease) With Adverse Renal Prognosis to Evaluate the Efficacy and Safety of IdeS --GOOD-IDES	Completed	NCT03157037	Phase 2
2	A Prospective Interventional Study to Investigate Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation With or Without Coagulation Factors Replacement	Unknown status	NCT03801135		Fibrinogen concentrate
3	Comparison of ANCA and Anti-GBM Auto-antibodies Removal Kinetics Between Plasma Exchanges and Immunoadsorption in Patients With ANCA-associated Vasculitis or Anti-GBM Disease	Recruiting	NCT03635385

Search NIH Clinical Center for Goodpasture Syndrome

Cochrane evidence based reviews: anti-glomerular basement membrane disease

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Genetic Tests for Goodpasture Syndrome

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Anatomical Context for Goodpasture Syndrome

MalaCards organs/tissues related to Goodpasture Syndrome:

⁴⁰

Kidney, Lung, Neutrophil, T Cells, Bone Marrow, Bone, Endothelial

Sources

Publications for Goodpasture Syndrome

Articles related to Goodpasture Syndrome:

(show top 50) (show all 495)

#	Title	Authors	PMID	Year
1	Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. ⁵⁷ ⁶¹	Kalluri R...Neilson EG	9410904	1997
2	Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen. ⁶¹ ⁵⁷	Turner N...Pusey CD	1737849	1992
3	Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. ⁵⁷	Ooi JD...Kitching AR	28467828	2017
4	Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. ⁵⁷	Pedchenko V...Hudson BG	20660402	2010
5	Alport's syndrome, Goodpasture's syndrome, and type IV collagen. ⁵⁷	Hudson BG...Neilson EG	12815141	2003
6	Goodpasture's syndrome in twins. ⁵⁷	Simonsen H...Ladefoged J	7158437	1982
7	Goodpasture's syndrome in identical twins. ⁵⁷	D'Apice AJ...Sands JM	563692	1978
8	Goodpasture's syndrome: a familial occurrence. ⁵⁷	Gossain VV...Janes AW	5017886	1972
9	Antineutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in a patient with anti-glomerular basement membrane disease. ⁶¹ ⁵⁴	Wanten GJ...Assmann KJ	7651563	1995
10	Prognostic implication of anti-neutrophil cytoplasmic autoantibodies with myeloperoxidase specificity in anti-glomerular basement membrane disease. ⁶¹ ⁵⁴	Bosch X...Revert L	1657470	1991
11	Clinicopathological characteristics and predictors of poor outcome in anti-glomerular basement membrane disease - a fifteen year single center experience. ⁶¹	Zahir Z...Jain M	33334228	2021
12	The clinical and immunological features of the post-extracorporeal shock wave lithotripsy anti-glomerular basement membrane disease. ⁶¹	Wang B...Zhao M	33435789	2021
13	Atypical anti-glomerular basement membrane disease with anti-GBM antibody negativity and ANCA positivity: a case report. ⁶¹	Guo N...Fu P	33546629	2021
14	Sequential occurrence of microscopic polyangiitis and anti-glomerular basement membrane disease in a patient with small cell lung cancer: a case report. ⁶¹	Hayashi Y...Fukui M	33517889	2021
15	Idiopathic pulmonary hemosiderosis: A state of the art review. ⁶¹	Saha BK	33246295	2021
16	Atypical anti-glomerular basement membrane disease complicated by methicillin-susceptible Staphylococcus aureus infection-related rapidly progressive glomerulonephritis: a case report and literature review. ⁶¹	Yamashita T...Kobayashi H	33460013	2021
17	The Challenging Management of Cancer: An Immunonephrologist's Perspective. ⁶¹	Fenoglio R...Sciascia S	33326976	2021
18	Anti-glomerular Basement Membrane Disease: What Have We Learned? ⁶¹	Akhtar M...Asim M	32991349	2021
19	Double filtration plasmapheresis - 10-year pediatric experience as an alternative to plasma exchange. ⁶¹	Maxted AP...Hussain F	32919882	2020
20	Hypertensive emergency and seizures in a 30-year-old man with anti-glomerular basement membrane disease. ⁶¹	Mascola M...Obligado S	33363926	2020
21	Long-term outcomes in kidney transplant recipients with end-stage kidney disease due to anti-glomerular basement membrane disease. ⁶¹	Singh T...Panzer SE	33259076	2020
22	Anti-Glomerular Basement Membrane Disease as a Potential Complication of COVID-19: A Case Report and Review of Literature. ⁶¹	Nahhal S...Ajami Z	33489507	2020
23	Imlifidase: First Approval. ⁶¹	Al-Salama ZT	33058042	2020
24	A patient with COVID-19 and anti-glomerular basement membrane disease. ⁶¹	Koc NS...Erdem Y	33139077	2020
25	The prevalence and immunological features of anti-glomerular basement membrane antibody in patients with HIV. ⁶¹	Wang WJ...Ying S	33032537	2020
26	Goodpasture syndrome manifesting as nephrotic-range proteinuria with anti-glomerular basement membrane antibody seronegativity: A case report. ⁶¹	Zhong Z...Qin W	32991448	2020
27	Anti-glomerular basement membrane disease during the COVID-19 pandemic. ⁶¹	Prendecki M...McAdoo SP	32599088	2020
28	Anti-glomerular basement membrane disease complicated with posterior reversible encephalopathy syndrome and subcortical cerebral hemorrhage: a case report and review of the literature. ⁶¹	Tsuneyoshi S...Kitazono T	32277358	2020
29	Renal Survival in Children with Glomerulonephritis with Crescents: A Pediatric Nephrology Research Consortium Cohort Study. ⁶¹	Maliakkal JG...Wenderfer SE	32722612	2020
30	A rare case of Goodpasture syndrome concomitant with bleeding jejunal Dieulafoy's lesion. ⁶¹	Kawabata H...Shikano T	31786734	2020
31	[Benefit of Howell-Jolly bodies detection: finding of an acquired hyposplenism in a patient with Goodpasture syndrome]. ⁶¹	Leroux T...Bobee V	32319948	2020
32	Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings. ⁶¹	Durcan ME...Anderton JG	32296530	2020
33	Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases. ⁶¹	Vavilapalli S...Raju SB	32317520	2020
34	Glomerulonephritis With Positive Anti-Glomerular Basement Membrane Antibodies Following Alemtuzumab Treatment. ⁶¹	White E...O'Riordan S	32815683	2020
35	Severe Infection in Anti-Glomerular Basement Membrane Disease: A Retrospective Multicenter French Study. ⁶¹	Caillard P...Titeca-Beauport D	32143501	2020
36	Atypical Anti-Glomerular Basement Membrane Disease With Diffuse Crescentic Membranoproliferative Glomerulonephritis: Case Report and Review of Literature. ⁶¹	Elshirbeny M...Fituri O	32391252	2020
37	Clinical-Pathological Features and Outcome of Atypical Anti-glomerular Basement Membrane Disease in a Large Single Cohort. ⁶¹	Shen CR...Zhao MH	33013861	2020
38	An uncommon presentation of a rare disease: A case of anti-glomerular basement membrane disease without renal involvement. ⁶¹	Polman J...Tati V	33294356	2020
39	[Review on anti-glomerular basement membrane disease or Goodpasture's syndrome]. ⁶¹	Marques C...Saadoun D	31776042	2020
40	Goodpasture syndrome and hemorrhage after renal biopsy: A case report. ⁶¹	Li WL...Luan SD	32047792	2020
41	A new mouse model of anti-GBM disease sheds light on maternal transfer of alloantibodies in glomerular disease. ⁶¹	Vivarelli M...Emma F	31759484	2019
42	Maternal alloimmune IgG causes anti-glomerular basement membrane disease in perinatal transgenic mice that express human laminin α5. ⁶¹	Abrahamson DR...Borza DB	31530475	2019
43	Atypical anti-glomerular basement membrane disease presenting as macroscopic haematuria, loin pain and acute kidney injury after intensive exercise. ⁶¹	Le Flecher A...Vacher Coponat H	31807293	2019
44	Odd combinations-coexistence of anti-glomerular basement membrane disease and Sjögren's syndrome. ⁶¹	Ahmed A...Roberts ISD	31170292	2019
45	Anti-glomerular basement membrane disease: an update on subgroups, pathogenesis and therapies. ⁶¹	Segelmark M...Hellmark T	30371823	2019
46	The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease. ⁶¹	Soveri I...Segelmark M	31563334	2019
47	IdeS in anti-glomerular basement membrane disease: Is this the new deal? ⁶¹	Rafat C...Luque Y	31648697	2019
48	Plasma exchange in anti-glomerular basement membrane disease. ⁶¹	Prendecki M...Pusey C	31703956	2019
49	Androgen deprivation therapy for prostate cancer and the risk of autoimmune diseases. ⁶¹	Liu JM...Hsu RJ	30692587	2019
50	Recurrent anti-GBM disease with T-cell large granular lymphocytic leukemia: A case report. ⁶¹	Zhang M...Xue J	31374037	2019

Sources

Genes for Goodpasture Syndrome

Genes related to Goodpasture Syndrome (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	42.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Disorders Publications Summaries (show sections)	8691734
2	MPO	Myeloperoxidase	Protein Coding	21.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7651563 1657470 8909258 (more) 9567081 1318119 2172672
3	CERT1	Ceramide Transporter 1	Protein Coding	13.23	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	12.75	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
5	NID1	Nidogen 1	Protein Coding	12.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	7.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	8869290
7	PRTN3	Proteinase 3	Protein Coding	7.63	DISEASES inferred ¹⁵
8	H2AC18	H2A Clustered Histone 18	Protein Coding	7.48	DISEASES inferred ¹⁵ ¹⁵
9	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.79	DISEASES inferred ¹⁵ ¹⁵
10	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	6.63	DISEASES inferred ¹⁵
11	PLA2R1	Phospholipase A2 Receptor 1	Protein Coding	6.52	DISEASES inferred ¹⁵
12	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	6.48	DISEASES inferred ¹⁵
13	CD52	CD52 Molecule	Protein Coding	6.39	DISEASES inferred ¹⁵
14	ALB	Albumin	Protein Coding	6.07	DISEASES inferred ¹⁵
15	FCGR2B	Fc Fragment Of IgG Receptor IIb	Protein Coding	5.91	DISEASES inferred ¹⁵
16	PXDN	Peroxidasin	Protein Coding	5.87	DISEASES inferred ¹⁵
17	CD4	CD4 Molecule	Protein Coding	5.81	DISEASES inferred ¹⁵
18	FCGR2A	Fc Fragment Of IgG Receptor IIa	Protein Coding	5.66	DISEASES inferred ¹⁵
19	NPHS1	NPHS1 Adhesion Molecule, Nephrin	Protein Coding	5.63	DISEASES inferred ¹⁵
20	CFP	Complement Factor Properdin	Protein Coding	5.6	DISEASES inferred ¹⁵

Sources

Variations for Goodpasture Syndrome

Sources

Expression for Goodpasture Syndrome

Search GEO for disease gene expression data for Goodpasture Syndrome.

Sources

Pathways for Goodpasture Syndrome

Pathways related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	12.55	VCAM1 NID1 COL4A5 COL4A4 COL4A3
2	Tuberculosis ³⁶	12.03	PLA2R1 HLA-DRB1 FCGR2B FCGR2A
3	ECM-receptor interaction ³⁶ Show member pathways Integrin cell surface interactions ⁶⁵	11.93	VCAM1 COL4A5 COL4A4 COL4A3
4	Staphylococcus aureus infection ³⁶	11.69	HLA-DRB1 FCGR2B FCGR2A
5	Small cell lung cancer ³⁶	11.66	COL4A5 COL4A4 COL4A3
6	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.62	VCAM1 COL4A5 COL4A4 COL4A3
7	C-MYB transcription factor network ¹	11.58	PRTN3 MPO CD4
8	Primary Focal Segmental Glomerulosclerosis FSGS ¹	11.43	NPHS1 COL4A5 COL4A4 COL4A3
9	Cell adhesion_Plasmin signaling ²³	11.32	COL4A5 COL4A4 COL4A3
10	IgA-Producing B Cells in the Intestine ⁶⁴	11.28	VCAM1 FCGR2B FCGR2A CCR6
11	Phagosome ³⁶	11.2	PLA2R1 MPO HLA-DRB1 FCGR2B FCGR2A
12	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms ²³	11.18	COL4A5 COL4A4 COL4A3
13	NCAM1 interactions ⁶⁵	11.11	COL4A5 COL4A4 COL4A3
14	Cell adhesion_ECM remodeling ²³	11.04	NID1 COL4A5 COL4A4 COL4A3

Sources

GO Terms for Goodpasture Syndrome

Cellular components related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	10.13	VCAM1 PXDN PRTN3 NPHS1 NID1 MPO
2	extracellular region	GO:0005576	10.06	PXDN PRTN3 PLA2R1 NID1 MPO COL4A5
3	integral component of plasma membrane	GO:0005887	10.03	VCAM1 PLA2R1 NPHS1 HLA-DRB1 FCGR2B FCGR2A
4	extracellular space	GO:0005615	9.96	VCAM1 PXDN PRTN3 MPO HLA-DRB1 COL4A5
5	external side of plasma membrane	GO:0009897	9.85	VCAM1 HLA-DRB1 FCGR2B CD4 CCR6
6	basement membrane	GO:0005604	9.71	NID1 COL4A5 COL4A4 COL4A3
7	collagen trimer	GO:0005581	9.67	COL4A5 COL4A4 COL4A3 CERT1
8	endoplasmic reticulum lumen	GO:0005788	9.63	COL4A5 COL4A4 COL4A3 CFP CD4 ALB
9	collagen-containing extracellular matrix	GO:0062023	9.17	PXDN PRTN3 NID1 COL4A5 COL4A4 COL4A3
10	collagen type IV trimer	GO:0005587	9.13	COL4A5 COL4A4 COL4A3

Biological processes related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.7	PXDN HLA-DRB1 FCGR2B CFP CERT1 CD4
2	cellular oxidant detoxification	GO:0098869	9.5	PXDN MPO ALB
3	extracellular matrix organization	GO:0030198	9.43	VCAM1 PXDN NID1 COL4A5 COL4A4 COL4A3
4	positive regulation of viral entry into host cell	GO:0046598	9.4	HLA-DRB1 CD4
5	collagen-activated tyrosine kinase receptor signaling pathway	GO:0038063	9.37	COL4A5 COL4A3
6	positive regulation of monocyte differentiation	GO:0045657	9.26	HLA-DRB1 CD4
7	glomerular basement membrane development	GO:0032836	8.92	NPHS1 NID1 COL4A4 COL4A3

Molecular functions related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IgG binding	GO:0019864	9.16	FCGR2B FCGR2A
2	extracellular matrix structural constituent conferring tensile strength	GO:0030020	9.13	COL4A5 COL4A4 COL4A3
3	extracellular matrix structural constituent	GO:0005201	9.1	PXDN NID1 COL4A5 COL4A4 COL4A3 CD4

Sources

Sources for Goodpasture Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia