Gorham's Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Gorham's Disease

MalaCards integrated aliases for Gorham's Disease:

Name: Gorham's Disease ¹¹ ¹⁹ ⁷⁵ ¹⁴

Gorham-Stout Syndrome ¹¹ ¹⁹

Osteolysis, Essential ⁴³ ⁷¹

Cystic Angiomatosis of Bone Diffuse ¹⁹

Disappearing Bone Disease ¹¹

Vanishing Bone Disease ¹⁹

Gorham-Stout Disease ¹⁹

Essential Osteolysis ¹¹

Phantom Bone Disease ¹¹

Massive Osteolysis ¹¹

Osteolysis Massive ¹⁹

Massive Osteolyses ⁷¹

Gorham Disease ¹¹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4837

MeSH ⁴³ D010015

SNOMED-CT ⁶⁸ 240161003

UMLS ⁷¹ C0029436 C0029438

Sources

Summaries for Gorham's Disease

GARD: ¹⁹ Gorham's disease is a rare bone disorder characterized by bone loss (osteolysis), often associated abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone, or spread to soft tissue and adjacent bones. Symtoms may include pain, swelling, and increased risk of fracture. It may affect any part of the skeleton, but most commonly involves the skull, collarbone (clavicle), pelvis, ribs, spine, and/or jaw. Depending on the bones affected, various complications may occur. The cause of Gorham's disease is currently unknown. Most cases occur sporadically.

MalaCards based summary: Gorham's Disease, also known as gorham-stout syndrome, is related to bone disease and parathyroid gland disease. An important gene associated with Gorham's Disease is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Signal Transduction and TGF-Beta Pathway. The drugs Anesthetics and Endothelial Growth Factors have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and spinal cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology: ¹¹ A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.

Wikipedia: ⁷⁵ Gorham's disease (pronounced GOR-amz), also known as Gorham vanishing bone disease and phantom bone... more...

Sources

Related Diseases for Gorham's Disease

Diseases related to Gorham's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)

#	Related Disease	Score	Top Affiliating Genes
1	bone disease	30.8	TNFSF11 PTH IL6 CALCA
2	parathyroid gland disease	30.4	TNFSF11 PTH CALCA
3	meningitis	30.4	VEGFA IL6 CALCA
4	osteomyelitis	30.3	TNFSF11 IL6 CALCA
5	spondyloarthropathy 1	30.3	TNFSF11 PTH IL6
6	bone resorption disease	30.1	TNFSF11 PTH IL6 CALCA
7	hyperparathyroidism	30.0	TNFSF11 PTH CALCA
8	primary lymphedema	30.0	VEGFD VEGFC FLT4
9	primary hyperparathyroidism	30.0	TNFSF11 PTH CALCA
10	lymphangioleiomyomatosis	29.9	VEGFD VEGFC VEGFA PDPN
11	decubitus ulcer	29.8	VEGFA PECAM1 IL6
12	osteonecrosis	29.7	VEGFA PTH PECAM1
13	cerebral cavernous malformations	29.7	PROX1 PIK3CA PECAM1
14	generalized lymphatic anomaly	29.6	VEGFD VEGFC PROX1 PIK3CA PECAM1 LYVE1
15	vascular cancer	29.4	VEGFA PECAM1 IFNA2 FLT4
16	osteoporosis	29.3	VEGFA TNFSF11 PTH IL6 CALCA
17	aortic aneurysm, familial abdominal, 1	29.3	VEGFA PECAM1 IL6
18	myeloma, multiple	29.2	VEGFA TNFSF11 PIK3CA IL6 IFNA2
19	klippel-trenaunay-weber syndrome	29.1	VEGFA PROX1 PIK3CA PECAM1 FLT4
20	capillary hemangioma	29.1	VEGFA PROX1 PECAM1 FLT4
21	hereditary lymphedema i	29.1	VEGFD VEGFC PROX1 PDPN LYVE1 FLT4
22	lymphangioma	28.4	VEGFC VEGFA PROX1 PIK3CA PECAM1 PDPN
23	hemangioma	28.2	VEGFC VEGFA PROX1 PECAM1 PDPN LYVE1
24	multicentric osteolysis, nodulosis, and arthropathy	11.1
25	cystic angiomatosis of bone, diffuse	10.6
26	cerebrospinal fluid leak	10.5
27	lymphatic system disease	10.5
28	otorrhea	10.4
29	kaposiform lymphangiomatosis	10.4
30	lymphangiomatosis	10.4
31	congenital hemidysplasia with ichthyosiform erythroderma and limb defects	10.4
32	intracranial hypotension	10.4
33	children's interstitial lung disease	10.4
34	rare lymphatic malformation	10.3
35	neural tube defects	10.3
36	meningocele	10.3
37	pericardial effusion	10.3
38	papilledema	10.3
39	chiari malformation	10.3
40	overgrowth syndrome	10.3
41	tetanic cataract	10.3	PTH CALCA
42	paget disease of bone 5, juvenile-onset	10.3	TNFSF11 CALCA
43	substernal goiter	10.3	PTH CALCA
44	kohler's disease	10.3	PTH CALCA
45	telangiectatic osteogenic sarcoma	10.3	TNFSF11 CALCA
46	isthmus cancer	10.2	PTH CALCA
47	periodontitis, chronic	10.2	TNFSF11 IL6
48	malignant ciliary body melanoma	10.2	PROX1 LYVE1
49	ciliary body cancer	10.2	PROX1 LYVE1
50	hypervitaminosis d	10.2	PTH CALCA

Graphical network of the top 20 diseases related to Gorham's Disease:

Sources

Symptoms & Phenotypes for Gorham's Disease

MGI Mouse Phenotypes related to Gorham's Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.18	CALCA FLT4 IL6 PDPN PECAM1 PIK3CA
2	cardiovascular system	MP:0005385	10.1	CALCA FLT4 IL6 LYVE1 PDPN PECAM1
3	immune system	MP:0005387	10.07	FLT4 IFNA2 IL6 LYVE1 PDPN PECAM1
4	muscle	MP:0005369	10.03	FLT4 IL6 PDPN PECAM1 PIK3CA PROX1
5	normal	MP:0002873	10	CALCA FLT4 IFNA2 PROX1 TNFSF11 VEGFA
6	neoplasm	MP:0002006	9.95	CALCA IL6 PIK3CA TNFSF11 VEGFA VEGFD
7	digestive/alimentary	MP:0005381	9.91	FLT4 IL6 PDPN PECAM1 PIK3CA PROX1
8	respiratory system	MP:0005388	9.76	CALCA IFNA2 IL6 PDPN PECAM1 PROX1
9	skeleton	MP:0005390	9.56	CALCA IL6 PDPN PECAM1 PIK3CA PTH
10	mortality/aging	MP:0010768	9.36	CALCA FLT4 IL6 PDPN PIK3CA PROX1

Sources

Drugs & Therapeutics for Gorham's Disease

Drugs for Gorham's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Anesthetics
2	Endothelial Growth Factors
3	Mitogens

Interventional clinical trials:

#	Name	Status	NCT ID
1	Dynamic Contrast Enhanced MR Lymphangiogram Imaging of Lymphatic Anomalies (LA)	Completed	NCT02744027
2	Identification of Biomarkers for Patients With Vascular Anomalies	Recruiting	NCT03001180
3	Lymphatic Anomalies Registry for the Assessment of Outcome Data	Recruiting	NCT02399527

Search NIH Clinical Center for Gorham's Disease

Cochrane evidence based reviews: osteolysis, essential

Sources

Genetic Tests for Gorham's Disease

Sources

Anatomical Context for Gorham's Disease

Organs/tissues related to Gorham's Disease:

MalaCards : Bone, Endothelial, Spinal Cord, Bone Marrow, Skin, Thyroid, Lung

Sources

Publications for Gorham's Disease

Articles related to Gorham's Disease:

(show top 50) (show all 745)

#	Title	Authors	PMID	Year
1	Characterization of Extracellular Vesicles in Osteoporotic Patients Compared to Osteopenic and Healthy Controls. ⁶²	Pepe J...Del Fattore A	36053959	2022
2	Thoracic Gorham-Stout disease masquerading as an ovarian malignancy: a differential diagnosis in non-malignant causes of raised Ca-125 and overview of this rare pathology. ⁶²	Sattar A...Soleymani Majd H	36414336	2022
3	A case of restitution ad integrum in Gorham-Stout disease. ⁶²	Pickering ME...Ltaief-Boudrigua A	36332892	2022
4	[Complicated lymphatic anomaly: a clinicopathological analysis of four cases]. ⁶²	Pan BJ...Feng RE	36323545	2022
5	Vascular Anomaly Syndromes in the ISSVA Classification System: Imaging Findings and Role of Interventional Radiology in Management. ⁶²	Wang MX...Chau A	36190850	2022
6	EBRA Migration Analysis of a Modular, Distally Fixed Stem in Hip Revision Arthroplasty: A Clinical and Radiological Study. ⁶²	Blum P...Dammerer D	36233724	2022
7	Difficult Therapeutic Decisions in Gorham-Stout Disease-Case Report and Review of the Literature. ⁶²	Wojciechowska-Durczynska K...Lewinski A	36141975	2022
8	Gorham-Stout disease, a diagnosis of exclusion. ⁶²	Ahmetgjekaj I...Musa J	35814817	2022
9	How we approach the diagnosis and management of complex lymphatic anomalies. ⁶²	Ricci KW...Iacobas I	33844431	2022
10	Dynamic Contrast-Enhanced Magnetic Resonance Lymphangiography and Lymphatic Interventions for Pediatric Patients with Various Lymphatic Diseases. ⁶²	Ahn Y...Shin JH	35984923	2022
11	Embolism After Injection of a Calcium Sulfate Bone Graft Substitute: A Case Report. ⁶²	Tadje JM...Daines SB	36137174	2022
12	When "milky fluid" was aspirated from the bone: Gorham-Stout syndrome-A report of a rare entity. ⁶²	Gupta R...Ora M	35899433	2022
13	Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies. ⁶²	Geng X...Srinivasan RS	35817543	2022
14	Inflammatory tissue reactions around aseptically loose cemented hip prostheses: A retrieval study of the Spectron EF stem with Reflection All-Poly acetabular cup. ⁶²	Wolf S...Hol PJ	35099116	2022
15	"A case of vanishing bone disease complicated by chylothorax- diagnosis and treatment". ⁶²	Suzuki N...Kubba F	35774987	2022
16	Spouting Chylothorax in Gorham-Stout Disease. ⁶²	Nomura M...Yamaguchi Y	35104434	2022
17	Lymphatic Anomalies in Children: Update on Imaging Diagnosis, Genetics, and Treatment. ⁶²	Snyder EJ...Tekes A	35043669	2022
18	Gorham-Stout disease with life-threatening pleural effusion treated with a pleuro-peritoneal shunt: a case report. ⁶²	Toivonen LA...Metso S	35642669	2022
19	Gorham-Stout case report: a multi-omic analysis reveals recurrent fusions as new potential drivers of the disease. ⁶²	Yebenes Mayordomo M...Alfaro JA	35668402	2022
20	Gorham-Stout disease of skull base leading to cranial settling and rhinorrhea: a case-based review. ⁶²	Maroufi SF...Nejat F	35217940	2022
21	Vanishing Lymphocytes in a Case of Vanishing Bone Disease. ⁶²	Iyengar VV...Desai MM	35089478	2022
22	Refractory serositis in Gorham-Stout syndrome. ⁶²	Di H...Zeng X	35379268	2022
23	Non-secretory myeloma in young man mimicking the Gorham disease: case report and the literature review. ⁶²	Ferjani HL...Hamdi W	34610233	2022
24	Vanishing Bone Disease of the Thoracic Cage: Challenges in the Management of a Rare Entity. ⁶²	Cherian KE...Paul TV	35415229	2022
25	The importance of computed tomography (CT) scans in the early diagnosis of Gorham-Stout Disease - A case report. ⁶²	Hyseni F...Musa J	34950281	2022
26	Gorham Stout disease of the temporal bone with cerebrospinal fluid leak. ⁶²	Aouad P...Ryan ME	34115176	2022
27	Gorham-Stout syndrome mimicking a malignant bone tumor in two adult cases. ⁶²	Toda Y...Kawai A	34585240	2022
28	Surgical treatment of severe thoracic kyphosis and neurological deficit in a patient with Gorham-Stout syndrome: A case report and literature review. ⁶²	Zhang H...Zhou L	36003281	2022
29	Endoscopic Endonasal Dural Reconstruction for a Cerebrospinal Fluid Leak in the Middle Cranial Fossa of a Patient with Gorham-stout Disease with Skull Base Defect. ⁶²	Morinaga Y...Ishikawa E	35493538	2022
30	Idiopathic focal calvarial thinning: A case report. ⁶²	Tsukada A...Ishikawa E	36447892	2022
31	A Case of Gorham-Stout Disease of the Skull Base Treated With Intensity Modulated Radiation Therapy. ⁶²	Roy A...Daly MD	34729445	2022
32	Gorham-Stout disease: A multirod lumbar reconstruction with off-label suppression-remission therapy. ⁶²	Krishnan A...Dave B	35509593	2022
33	Bacterial meningitis due to the Streptococcus mitis group in children with cerebrospinal fluid leak. ⁶²	Fukayama H...Miyairi I	35145856	2022
34	Daratumumab, Lenalidomide, and Dexamethasone (DRD), an Active Regimen in the Treatment of Immunosuppression-Associated Plasmablastic Lymphoma (PBL) in the Setting of Gorham's Lymphangiomatosis: Review of the Literature. ⁶²	Lee M...Abdulhaq H	35795542	2022
35	[Unilateral subjective tinnitus «vanishing bone» disease (Goram-Stout syndrome).] ⁶²	Kryukov AI...Donyush EK	36404698	2022
36	Current concepts from diagnosis to management in Gorham-Stout disease: a systematic narrative review of about 350 cases. ⁶²	Angelini A...Ruggieri P	35076412	2022
37	Complication rates following all-epiphyseal ACL reconstructions in skeletally immature patients: A retrospective case series study. ⁶²	Saad L...Nault ML	34964784	2021
38	Cerebrospinal fluid-lymphatic fistula causing spontaneous intracranial hypotension in a child with kaposiform lymphangiomatosis. ⁶²	Soderlund KA...Dillon WP	34286352	2021
39	Massive osteolysis in a patient with Gorham-Stout syndrome. ⁶²	Lopez Garcia IM...Cuesta Marcos MT	34625153	2021
40	Surgical treatment of a patient with Gorham-Stout disease of craniovertebral junction: case report and literature review. ⁶²	Evsyukov A...Rzaev J	34585642	2021
41	A narrative review of the role of sirolimus in the treatment of congenital vascular malformations. ⁶²	Geeurickx M...Labarque V	33737259	2021
42	Severe adverse events during sirolimus "off-label" therapy for vascular anomalies. ⁶²	Rossler J...Kapp FG	33580918	2021
43	A Case of Gorham-Stout Disease Treated with Fistula Closure by Transmeatal Approach. ⁶²	Watanabe T...Fujiwara K	34434067	2021
44	KRAS-driven model of Gorham-Stout disease effectively treated with trametinib. ⁶²	Homayun-Sepehr N...Dellinger MT	34156985	2021
45	The loneliness of a long-distance runner. A ten-year survey of a patient diagnosed with Gorham-Stout syndrome at the occipitocervical junction. ⁶²	Gezercan Y...Harman F	34414839	2021
46	Young adult with Gorham's disease presenting in an emergency department: a case report. ⁶²	Gronroos M...Palomaki A	34399846	2021
47	Gorham's disease of the maxilla - A rare case report with literature overview. ⁶²	Patil DJ...Konidena A	34007397	2021
48	Imaging Spectrum of Calvarial Abnormalities. ⁶²	Khodarahmi I...Wenokor C	34197249	2021
49	Radiographic extent of maxillofacial Gorham's disease and its impact on recurrence: A systematic review. ⁶²	Sansare K...Sreenivasan V	34020915	2021
50	Gorham-Stout Disease with Multiple Bone Involvement-Challenging Diagnosis of a Rare Disease and Literature Review. ⁶²	Momanu A...Gorduza EV	34356962	2021

Sources

Genes for Gorham's Disease

Genes related to Gorham's Disease (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IFNA2	Interferon Alpha 2	Protein Coding	6.61	DISEASES inferred ¹⁴
2	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	5.95	DISEASES inferred ¹⁴
3	LYVE1	Lymphatic Vessel Endothelial Hyaluronan Receptor 1	Protein Coding	5.95	DISEASES inferred ¹⁴
4	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	5.79	DISEASES inferred ¹⁴
5	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	5.45	DISEASES inferred ¹⁴
6	TNFSF11	TNF Superfamily Member 11	Protein Coding	5.34	DISEASES inferred ¹⁴
7	IL6	Interleukin 6	Protein Coding	5.3	DISEASES inferred ¹⁴
8	PTH	Parathyroid Hormone	Protein Coding	5.27	DISEASES inferred ¹⁴
9	PROX1	Prospero Homeobox 1	Protein Coding	5.22	DISEASES inferred ¹⁴
10	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	5.18	DISEASES inferred ¹⁴
11	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	5.16	DISEASES inferred ¹⁴
12	PDPN	Podoplanin	Protein Coding	5.13	DISEASES inferred ¹⁴
13	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	4.98	DISEASES inferred ¹⁴
14	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	4.9	DISEASES inferred ¹⁴

Sources

Variations for Gorham's Disease

Sources

Expression for Gorham's Disease

Search GEO for disease gene expression data for Gorham's Disease.

Sources

Pathways for Gorham's Disease

Pathways related to Gorham's Disease according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.64	VEGFD VEGFC VEGFA PTH PIK3CA IL6
2	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.41	VEGFD VEGFC VEGFA PIK3CA IL6 IFNA2
3	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.14	IFNA2 PDPN PECAM1 PIK3CA VEGFA VEGFC
4	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.72	VEGFD VEGFC VEGFA PIK3CA FLT4
5	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.72	VEGFD VEGFC VEGFA PIK3CA IL6 IFNA2
6	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.57	VEGFD VEGFC IL6 FLT4
7	Malignant pleural mesothelioma ⁷⁴	12.49	FLT4 IL6 PIK3CA VEGFA VEGFC VEGFD
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.48	VEGFD VEGFC PIK3CA IL6 IFNA2 FLT4
9	VEGF Pathway (Qiagen) ⁶⁴ Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Development VEGF-family signaling ²² Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF and VEGFR signaling network ⁶¹ VEGF Family Ligands and Receptor Interactions ⁶⁴	12.31	VEGFD VEGFC VEGFA PIK3CA FLT4
10	RhoGDI Pathway ⁶⁴ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶⁴	12.3	VEGFD VEGFC VEGFA FLT4
11	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.26	VEGFD VEGFC PIK3CA IL6 FLT4
12	Focal adhesion ⁷⁴	12.16	VEGFD VEGFC VEGFA PIK3CA
13	Signaling by VEGF ⁶⁶ Show member pathways VEGFA-VEGFR2 Pathway ⁶⁶	12.15	VEGFD VEGFC VEGFA PIK3CA FLT4
14	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.94	VEGFA PROX1 IL6
15	CCL18 signaling pathway ⁷⁴	11.8	VEGFC VEGFA IL6
16	Clock-controlled autophagy in bone metabolism ⁷⁴	11.68	TNFSF11 PTH IL6 CALCA
17	Burn wound healing ⁷⁴	11.63	VEGFA PECAM1 IL6 IFNA2
18	IL 10 signaling pathway ⁶⁷	11.57	TNFSF11 PIK3CA IL6
19	SHP2 signaling ⁶¹	11.5	VEGFA PIK3CA IL6
20	Angiogenesis (CST) ³	11.5	VEGFC PROX1 PECAM1 PDPN FLT4
21	HIF1Alpha Pathway ⁶⁴	11.49	VEGFD VEGFC VEGFA
22	Pluripotent stem cell differentiation pathway ⁷⁴	11.42	VEGFA TNFSF11 IL6
23	IL6-mediated signaling events ⁶¹	11.38	TNFSF11 PIK3CA IL6
24	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.28	TNFSF11 PTH IL6 CALCA
25	Alpha9 beta1 integrin signaling events ⁶¹	11.08	VEGFD VEGFC VEGFA
26	Regucalcin in proximal tubule epithelial kidney cells ⁷⁴	10.99	PTH CALCA
27	Immune infiltration in pancreatic cancer ⁷⁴	10.99	VEGFD VEGFC VEGFA IL6
28	G-protein signaling_Rap2B regulation pathway ²²	10.91	FLT4 IL6 TNFSF11 VEGFC VEGFD
29	VEGFR3 signaling in lymphatic endothelium ⁶¹	10.64	VEGFD VEGFC PIK3CA FLT4
30	MicroRNA for targeting cancer growth and vascularization in glioblastoma ⁷⁴ Show member pathways Oncostatin M signaling pathway ⁷⁴	10.59	VEGFC VEGFA
31	VEGF ligand-receptor interactions ⁶⁶ Show member pathways VEGF binds to VEGFR leading to receptor dimerization ⁶⁶	10.13	VEGFD VEGFC VEGFA FLT4

Sources

GO Terms for Gorham's Disease

Cellular components related to Gorham's Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.11	VEGFD VEGFC VEGFA TNFSF11 PTH IL6
2	extracellular space	GO:0005615	9.58	VEGFD VEGFC VEGFA TNFSF11 PTH PECAM1
3	platelet alpha granule lumen	GO:0031093	9.43	VEGFA VEGFC VEGFD

Biological processes related to Gorham's Disease according to GeneCards Suite gene sharing:

(show all 26)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell population proliferation	GO:0008284	10.31	FLT4 IL6 PROX1 VEGFA VEGFC VEGFD
2	positive regulation of cell migration	GO:0030335	10.13	VEGFC VEGFA PECAM1 PDPN FLT4
3	positive regulation of protein phosphorylation	GO:0001934	10.13	FLT4 PECAM1 VEGFA VEGFC VEGFD
4	angiogenesis	GO:0001525	10.1	FLT4 PIK3CA VEGFA VEGFC VEGFD
5	activation of protein kinase activity	GO:0032147	10.08	VEGFA PIK3CA CALCA
6	positive regulation of endothelial cell migration	GO:0010595	10.08	VEGFA PROX1 FLT4
7	platelet activation	GO:0030168	10.07	PIK3CA PDPN IL6
8	positive regulation of cell division	GO:0051781	10.04	VEGFD VEGFC VEGFA
9	monocyte chemotaxis	GO:0002548	10.03	TNFSF11 IL6 CALCA
10	positive chemotaxis	GO:0050918	10.02	VEGFD VEGFC VEGFA
11	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	10.01	VEGFA IL6 IFNA2
12	positive regulation of platelet aggregation	GO:1901731	9.93	PDPN IL6
13	positive regulation of protein kinase C signaling	GO:0090037	9.92	VEGFA FLT4
14	sprouting angiogenesis	GO:0002040	9.92	FLT4 VEGFA VEGFC VEGFD
15	positive regulation of extracellular matrix disassembly	GO:0090091	9.88	PDPN IL6
16	hepatocyte proliferation	GO:0072574	9.88	IL6 PROX1
17	induction of positive chemotaxis	GO:0050930	9.88	VEGFD VEGFC VEGFA
18	vasculature development	GO:0001944	9.85	PIK3CA FLT4 CALCA
19	lymphangiogenesis	GO:0001946	9.85	PROX1 PDPN FLT4
20	lymphatic endothelial cell fate commitment	GO:0060838	9.83	PROX1 PDPN
21	lymph vessel development	GO:0001945	9.8	PROX1 FLT4
22	vascular endothelial growth factor receptor signaling pathway	GO:0048010	9.76	VEGFD VEGFC VEGFA FLT4
23	positive regulation of mast cell chemotaxis	GO:0060754	9.73	VEGFD VEGFC VEGFA
24	positive regulation of phosphorylation	GO:0042327	9.69	VEGFA TNFSF11 FLT4
25	positive regulation of endothelial cell proliferation	GO:0001938	9.65	VEGFD VEGFC VEGFA PROX1 FLT4
26	vascular endothelial growth factor signaling pathway	GO:0038084	9.32	VEGFD VEGFC VEGFA PIK3CA FLT4

Molecular functions related to Gorham's Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.97	VEGFA TNFSF11 IL6 IFNA2
2	growth factor activity	GO:0008083	9.92	VEGFD VEGFC VEGFA IL6
3	chemoattractant activity	GO:0042056	9.73	VEGFD VEGFC VEGFA
4	vascular endothelial growth factor receptor 3 binding	GO:0043185	9.46	VEGFD VEGFC
5	receptor ligand activity	GO:0048018	9.43	VEGFD VEGFC VEGFA PTH
6	vascular endothelial growth factor receptor binding	GO:0005172	9.1	VEGFD VEGFC VEGFA

Sources

Sources for Gorham's Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: GRH001 MIFTS: 43	Gorham's Disease Categories: Blood diseases, Bone diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables