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MCID: GT001
MIFTS: 57

Gout

Categories: Bone diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Gout

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MalaCards integrated aliases for Gout:

Name: Gout 12 76 37 55 6 43 3 44 15 63 73
Arthritis, Gouty 44 73
Gouty Arthropathy 12
Gouty Arthritis 12
Arthritis Gouty 55
Articular Gout 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Gout

About this section
MedlinePlus : 43 Gout is a common, painful form of arthritis. It causes swollen, red, hot and stiff joints. Gout happens when uric acid builds up in your body. Uric acid comes from the breakdown of substances called purines. Purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. Normally, uric acid dissolves in the blood. It passes through the kidneys and out of the body in urine. But sometimes uric acid can build up and form needle-like crystals. When they form in your joints, it is very painful. The crystals can also cause kidney stones. Often, gout first attacks your big toe. It can also attack ankles, heels, knees, wrists, fingers, and elbows. At first, gout attacks usually get better in days. Eventually, attacks last longer and happen more often. You are more likely to get gout if you Are a man Have family member with gout Are overweight Drink alcohol Eat too many foods rich in purines Gout can be hard to diagnose. Your doctor may take a sample of fluid from an inflamed joint to look for crystals. You can treat gout with medicines. Pseudogout has similar symptoms and is sometimes confused with gout. However, it is caused by calcium phosphate, not uric acid. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Gout, also known as arthritis, gouty, is related to hyperuricemic nephropathy, familial juvenile, 1 and phosphoribosylpyrophosphate synthetase superactivity, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Gout is DARS2 (Aspartyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Purine metabolism and Purine metabolism (KEGG). The drugs Colchicine and Allopurinol have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and heart, and related phenotype is renal/urinary system.

Disease Ontology : 12 An arthritis that has material basis in uric acid crystal deposits located in joint.

PubMed Health : 63 About gout: Gout is a metabolic disorder which causes inflammation of the joints. During acute episodes, certain joints swell up within just a few hours and become very sensitive to pain. The inflammation is triggered by tiny needle-shaped crystals of uric acid that mainly build up in the joints. These crystals may form if there is too much uric acid in the body. The inflammation normally goes away on its own within one to two weeks. The pain can be relieved with medication.Most people with gout experience acute attacks every now and then. Months or even years can pass between attacks, but they may be more frequent too. There are a number of options to prevent them. Some people already notice an improvement if they avoid certain foods and other possible triggers. Others may take medication to lower their uric acid levels over the long term. The medication is mostly considered for people who have frequent gout attacks or complications such as kidney stones or lumps called tophi.Many people have high levels of uric acid without it causing any noticeable problems. It's not clear whether this affects their health. It doesn't need to be treated.

Wikipedia : 76 Gout is a form of inflammatory arthritis characterized by recurrent attacks of a red, tender, hot, and... more...

Sources

Related Diseases for Gout

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Diseases related to Gout via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 hyperuricemic nephropathy, familial juvenile, 1 33.7 HPRT1 SLC22A12 UMOD
2 phosphoribosylpyrophosphate synthetase superactivity 33.6 HPRT1 PRPS1
3 kelley-seegmiller syndrome 33.0 APRT HPRT1
4 lesch-nyhan syndrome 31.3 ADSL APRT HPRT1 XDH
5 nephrolithiasis 29.9 APRT SLC22A12 SLC2A9
6 adenine phosphoribosyltransferase deficiency 29.7 APRT HPRT1 XDH
7 hyperuricemia 29.6 ABCG2 HPRT1 SLC17A1 SLC17A3 SLC22A12 SLC2A9
8 uric acid concentration, serum, quantitative trait locus 1 11.6
9 familial juvenile hyperuricaemic nephropathy 11.6
10 arthritis 11.3
11 crystal arthropathies 11.2
12 chondrocalcinosis 2 11.1
13 autosomal dominant tubulointerstitial kidney disease 11.1
14 uric acid concentration, serum, quantitative trait locus 4 11.0
15 medullary cystic kidney disease 2 10.8
16 autosomal dominant tubulointerstitial kidney disease, umod-related 10.8
17 nephronophthisis-like nephropathy 1 10.8
18 occipital neuralgia 10.8
19 nephrolithiasis, uric acid 10.7 HPRT1 XDH
20 hypouricemia, renal, 1 10.6 HPRT1 SLC22A12 SLC2A9
21 acute urate nephropathy 10.4 CARMIL1 SLC22A12
22 vulvar vestibulitis syndrome 10.3 IL1B NLRP3
23 cervical adenitis 10.3 IL1B NLRP3
24 familial cold autoinflammatory syndrome 1 10.3 IL1B NLRP3
25 hereditary xanthinuria 10.2 APRT XDH
26 schnitzler syndrome 10.2 IL1B NLRP3
27 primary amebic meningoencephalitis 10.2 IL1B XDH
28 arthropathy 10.1
29 kidney disease 10.1
30 chronic recurrent multifocal osteomyelitis 10.1 IL1B NLRP3
31 rheumatoid arthritis 10.1
32 chronic kidney failure 10.1
33 xanthinuria, type i 10.0 APRT UMOD XDH
34 nephrolithiasis, calcium oxalate 10.0 APRT UMOD XDH
35 dupuytren contracture 9.9 IL1B XDH
36 diabetes mellitus, noninsulin-dependent 9.9
37 osteoarthritis 9.9
38 chondrocalcinosis 9.9
39 septic arthritis 9.9
40 aging 9.9
41 bursitis 9.9
42 myocardial infarction 9.9
43 glycogen storage disease 9.9
44 epidural abscess 9.9
45 carpal tunnel syndrome 9.8
46 kearns-sayre syndrome 9.8
47 mononeuropathy of the median nerve, mild 9.8
48 enthesopathy 9.8
49 cervicitis 9.8
50 cystic kidney disease 9.8

Comorbidity relations with Gout via Phenotypic Disease Network (PDN): (show all 27)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Aortic Valve Disease 1
Benign Essential Hypertension Bladder Neck Obstruction
Bronchitis Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Mitral Valve Disease Osteoarthritis
Peripheral Vascular Disease Prostate Cancer
Prostatic Hypertrophy Sinoatrial Node Disease
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Gout:



Diseases related to Gout
Sources

Symptoms & Phenotypes for Gout

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UMLS symptoms related to Gout:


back pain, muscle cramp, sciatica

MGI Mouse Phenotypes related to Gout:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.28 HPRT1 NLRP3 SLC22A12 SLC2A9 UMOD XDH
Sources

Drugs & Therapeutics for Gout

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PubMedHealth treatment related to Gout: 63

The treatment of gout has two aims:In the short term, it should provide pain relief during gout attacks.In the long term, it should prevent further attacks and lower the risk of chronic inflammations and joint damage.Gout attacks are treated with anti-inflammatory medications. These includeanti-inflammatory painkillers, such as ibuprofen, indometacine or naproxen,steroid medicines (usually tablets with prednisolone), as well asthe gout medicine colchicine. Because colchicine is slow to start working and has certain possible side effects, it is no longer used very often.If a single drug can’t provide enough pain relief, the treatments can be combined. Cooling the affected joint probably also helps, and most people find it very soothing.The goal of long-term gout treatment is to prevent gout attacks and complications by lowering the level of uric acid. This can be done in two ways:Changing your diet: Especially eating less meat, fish and seafood, and drinking less alcohol.Taking medication to lower your uric acid levels, typically allopurinol.Not everyone who has gout needs to take medicine to lower their uric acid levels. In particular, people who have already had a gout attack usually don’t need to take it. This is because some people don't have any problems after that for years, and others only have them rarely.Medication is mainly used if the attacks become more frequent or are very distressing. It also makes sense to take it if complications such as tophi or kidney stones have already developed, or if the functioning of the kidney is affected. Medication might also be an option if changes to your diet aren’t enough to make a difference.

Drugs for Gout (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 651)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colchicine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 64-86-8 6167 2833
2
Allopurinol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 315-30-0 2094
3
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
4
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 161796-78-7, 119141-88-7 4594 9579578
5
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22204-53-1 1302 156391
6
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 103-90-2 1983
7
Codeine Approved, Illicit Phase 4,Phase 2,Phase 3 76-57-3 5284371
8
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 93-14-1 3516
9
Tramadol Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 27203-92-5 33741
10
Amitriptyline Approved Phase 4 50-48-6 2160
11
Cyclobenzaprine Approved Phase 4 303-53-7 2895
12
Hydrocodone Approved, Illicit Phase 4,Not Applicable 125-29-1 5284569
13
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 76-42-6 5284603
14
Indomethacin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 53-86-1 3715
15
Febuxostat Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 144060-53-7 134018
16
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 15307-86-5 3033
17
Probenecid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-66-9 4911
18
Rasburicase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 134774-45-1
19
Nitric Oxide Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 10102-43-9 145068 160954
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
21
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-61-6, 62-31-7 681
22
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
23
Sumatriptan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 103628-46-2 5358
24
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 50-28-2 5757
25 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 979-32-8
26
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 1,Not Applicable 28014-46-2
27
Ketorolac Approved Phase 4,Phase 3,Not Applicable 74103-06-3, 66635-83-4 3826
28
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
29
Nifedipine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 21829-25-4 4485
30
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 73590-58-6 4594
31
Etoricoxib Approved, Investigational Phase 4,Phase 3 202409-33-4 123619
32
Lumiracoxib Approved, Investigational Phase 4 220991-20-8 151166
33
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
34
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
35
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
36
Theophylline Approved Phase 4,Phase 1 58-55-9 2153
37
Coal tar Approved Phase 4,Phase 3 8007-45-2
38
Ephedrine Approved Phase 4,Phase 3,Phase 1 299-42-3 9294
39
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1 90-82-4 7028
40
Ranibizumab Approved Phase 4 347396-82-1 459903
41
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
42
Orphenadrine Approved Phase 4 83-98-7 4601
43
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
44
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
45
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
46
Morphine Approved, Investigational Phase 4 57-27-2 5288826
47
Copper Approved, Investigational Phase 4 7440-50-8 27099
48
Tranexamic Acid Approved Phase 4 1197-18-8 5526
49
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
50
Meloxicam Approved, Vet_approved Phase 4,Phase 3,Phase 2 71125-38-7 5281106 54677470

Interventional clinical trials:

(show top 50) (show all 855)
# Name Status NCT ID Phase Drugs
1 Post-MI PET Scan Imaging of Inflammation Unknown status NCT02281305 Phase 4 Colchicine
2 Colchicine in ST-elevation Myocardial Infarction Unknown status NCT01936285 Phase 4 Colchicine 2 mg loading dose; 0.5 mg bid for 5 days;Placebo
3 Colchicine for Acute Coronary Syndromes Unknown status NCT01906749 Phase 4 Colchicine;Placebo
4 Microalbuminuria and Allopurinol in Type 1 Diabetes Unknown status NCT02829177 Phase 4 Allopurinol;Placebo
5 Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines Unknown status NCT02797028 Phase 4 Allopurinol
6 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
7 Postoperative Analgesia in Laminectomy Unknown status NCT02255955 Phase 4 550 mg naproxen sodium and 30mg codeine;300 mg paracetamol and 30 mg codeine;placebo tablet
8 Efficacy of Intravenous Naproksen Sodium+Codein and Paracetamol+Codein on Postoperative Pain on Postoperative Pain Unknown status NCT02252614 Phase 4 naproxen sodium codein;paracetamol codein;Placebo
9 A Randomized Study of Three Medication Regimens for Acute Low Back Pain Unknown status NCT01587274 Phase 4 Naproxen;Cyclobenzaprine;Oxycodone/ acetaminophen
10 Naproxen for Acute Pain After Surgery: A Randomized, Placebo-Controlled Trial Unknown status NCT00615875 Phase 4 naproxen;placebo
11 Does Allopurinol Prolong a Treated, Acute Gout Flare? Completed NCT01988402 Phase 4 allopurinol;Placebo (sugar pill)
12 Initiation of Allopurinol at First Medical Contact for Acute Attacks of Gout Completed NCT01310673 Phase 4 Allopurinol;Placebo
13 Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels Completed NCT02060552 Phase 4 Diacerein;Colchicine;Febuxostat
14 Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol Completed NCT01451645 Phase 4 Colchicine (Colcrys®);placebo;allopurinol
15 Colchicine Or Naproxen Treatment for ACute gouT Completed NCT01994226 Phase 4 Low-dose colchicine;Naproxen 750 mg/250 mg
16 An Assessment of Chronic Synovial-Based Inflammation and Its Role With Serum Urate Levels. Completed NCT01112982 Phase 4 Febuxostat;Colchicine
17 Intensive Urate Lowering Therapy of Febuxostat Compared to Allopurinol on Cardiovascular Risk in Patients With Gout Completed NCT02500641 Phase 4 Febuxostat 80/120mg/day;Allopurinol 100 up to 600mg/day;Colchicine;Naproxen;Omeprazole
18 A Study Evaluating the Effect of Etoricoxib and Indomethacin in the Treatment of Acute Gout (0663-081)(COMPLETED) Completed NCT00142558 Phase 4 MK0663; etoricoxib / Duration of Treatment: 5 Days;Comparator: indomethacin 75 mg sustained release capsule / Duration of Treatment: 5 Days
19 Allopurinol Outcome Study Completed NCT01391325 Phase 4 Allopurinol
20 Efficacy and Safety of Lumiracoxib 400 mg Once Daily in Acute Flares of Gout Completed NCT00170781 Phase 4 Lumiracoxib
21 Effects of Hyperuricemia Reversal on Features of the Metabolic Syndrome Completed NCT01654276 Phase 4 Febuxostat
22 Optimal Administration of Allopurinol in Dialysis Patients Completed NCT02477488 Phase 4 Allopurinol
23 Zurig (Febuxostat) 40mg Efficacy and Safety Trial Completed NCT02600780 Phase 4 Febuxostat;Allopurinol
24 Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure Completed NCT01472692 Phase 4 Febuxostat
25 Postmarketing Study to Determine Performance of the SIGMA HP® PARTIAL KNEE SYSTEM Completed NCT01529099 Phase 4
26 Do Xanthine Oxidase Inhibitors Reduce Both Left Ventricular Hypertrophy and Endothelial Dysfunction in Cardiovascular Patients With Renal Dysfunction? Completed NCT00688480 Phase 4 Placebo;Allopurinol
27 Drug Interaction Study of Olmesartan in Healthy Chinese Volunteers Completed NCT01907373 Phase 4 olmesartan medoxomil;olmesartan medoxomil+probenecid
28 Does ALlopurinol Regress lefT Ventricular Hypertrophy in End Stage REnal Disease: The ALTERED Study Completed NCT01951404 Phase 4 Allopurinol;Placebo (for allopurinol)
29 The Influence of Febuxostat on Coronary Artery Endothelial Dysfunction in Participants With Chronic Stable Angina Completed NCT01763996 Phase 4 Febuxostat;Febuxostat placebo
30 Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS) Completed NCT01328769 Phase 4 Febuxostat;Placebo
31 Fasturtec TLS Treatment / Prophylysis Completed NCT00651911 Phase 4 urate oxidase
32 Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrome Completed NCT00563771 Phase 4 Rasburicase
33 Rasburicase in Tumor Lysis Syndrome Completed NCT00302653 Phase 4 Rasburicase
34 Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome in Patients With Relapsed or Refractory Lymphoma, Leukemia, or Solid Tumor Malignancy Completed NCT00230217 Phase 4 Rasburicase (SR29142)
35 The Effect of Uric Acid Lowering in Type 1 Diabetes Completed NCT02344602 Phase 4 Febuxostat
36 Efficacy of Proprietary Cherry Juice Blend in Osteoarthritis of the Knee Completed NCT00443092 Phase 4
37 Treatment of Hyperuricemia in Patients With Heart Failure Completed NCT00422318 Phase 4 Benzbromarone (drug)
38 Diuretics In the Management of Essential Hypertension (DIME) Study Completed NCT00131846 Phase 4 Thiazide diuretics;No diuretics
39 The Comparison of the Efficacy of Once and Twice Daily Colchicine Dosage in Pediatric Patients With FMF Completed NCT02602028 Phase 4 colchicine
40 Anti-platelet Effects of Colchicine in Healthy Volunteers Completed NCT02140372 Phase 4 Colchicine
41 Colchicine in Coronary Artery Bypass Graft (CABG) Completed NCT02122484 Phase 4 Colchicine
42 Drug Interaction Study of Colchicine and Theophylline Completed NCT01601132 Phase 4 theophylline;colchicine
43 Cochicine Treatment for Post- Operative Pericardial Effusion Completed NCT01266694 Phase 4 Colchicines;Placebo
44 A Pilot Study for PK/PD Parameter of Colchicine in Chronic Kidney Disease Patient. Completed NCT01173107 Phase 4 colchicine
45 Healthy and Renal Impairment Study of Colcrys (Colchicine, USP) Completed NCT01084278 Phase 4 Colchicine
46 Thiocolchicoside Injection and Capsule in Treatment of Acute Low Back Pain Completed NCT00917436 Phase 4 Thiocolchicoside
47 EMINEM: Efficacy of Muscoril In NEck Myofascial Syndromes Completed NCT00272532 Phase 4 Thiocolchicoside
48 Study of Colchicine to Treat and Prevent Recurrent Pericarditis After Failure of Conventional Treatment. Completed NCT00235079 Phase 4 Colchicine;Placebo
49 Effect of Allopurinol and Febuxostat on Urinary 2,8-Dihydroxyadenine Excretion Completed NCT02752633 Phase 4 Allopurinol;Febuxostat
50 Does Allopurinol Reduce Thickening of the Left Ventricle of the Heart in Patient With Treated Hypertension? Completed NCT02237339 Phase 4 Allopurinol;Placebo

Search NIH Clinical Center for Gout

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: gout

Sources

Genetic Tests for Gout

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Sources

Anatomical Context for Gout

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The Foundational Model of Anatomy Ontology organs/tissues related to Gout:

19
Joint

MalaCards organs/tissues related to Gout:

41
Kidney, Heart, Testes, Endothelial, Liver, Skin, Brain
Sources

Publications for Gout

About this section

Articles related to Gout:

(show top 50) (show all 1087)
# Title Authors Year
1
Burden of gout in the Nordic region, 1990-2015: findings from the Global Burden of Disease Study 2015. ( 29376465 )
2018
2
Gout: A Disease of Kings. ( 29393108 )
2018
3
Isolation and genomic characterization of gosling gout caused by a novel goose astrovirus. ( 29920970 )
2018
4
Correction: <i>An update on the management of gout</i>. ( 29980592 )
2018
5
Paraparesis revealing tophaceous gout. ( 29409109 )
2018
6
Genetic characterization of a new astrovirus in goslings suffering from gout. ( 29980852 )
2018
7
Next-generation sequencing profiling of mitochondrial genomes in gout. ( 29976239 )
2018
8
Synovial fluid uric acid level aids diagnosis of gout. ( 29930806 )
2018
9
Management of hyperuricemia and gout in obese patients undergoing bariatric surgery. ( 29888674 )
2018
10
Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa. ( 29980454 )
2018
11
Lesinurad/Allopurinol (Duzallo) for Gout-Associated Hyperuricemia. ( 29318274 )
2018
12
Predicting Response or Non-response to Urate-Lowering Therapy in Patients with Gout. ( 29931553 )
2018
13
Correction to: Retinal complications of gout: a case report and review of the literature. ( 29402259 )
2018
14
Study on the expressions of NLRP3 gene transcript variants in peripheral blood monocytes of primary gout patients. ( 29946988 )
2018
15
Keeping Up with the Applications: Lessons Learned Evaluating Gout Apps. ( 29969385 )
2018
16
Chronic gout: Barriers to effective management. ( 29966174 )
2018
17
A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility. ( 29080939 )
2018
18
Management of gout and hyperuricemia: Multidisciplinary consensus in Taiwan. ( 29363262 )
2018
19
Association of gout with osteoporotic fractures. ( 29955945 )
2018
20
Improved Gout Outcomes in Primary Care Using a Novel Disease Management Program: A Pilot Study. ( 29438607 )
2018
21
Erosive Gouty Arthropathy Resulting in a Telescoping Digit. ( 29794875 )
2018
22
Hypouricaemic effects of yogurt containing Lactobacillus gasseri PA-3 in patients with hyperuricaemia and/or gout: a randomized, double-blind, placebo-controlled study. ( 29446654 )
2018
23
Gout and arrhythmias: In search for causation beyond association. ( 29937218 )
2018
24
Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions for disease elements in gout. ( 29799677 )
2018
25
Advanced Imaging in the Diagnosis of Gout and Other Crystal Arthropathies. ( 29672810 )
2018
26
Impaired arterial responsiveness in untreated gout patients compared with healthy non-gout controls: association with serum urate and C-reactive protein. ( 29450849 )
2018
27
Managing Gout in the Patient with Renal Impairment. ( 29435850 )
2018
28
Gout drugs use and risk of cancer: A case-control study. ( 29427783 )
2018
29
Health-related quality of life in gout in primary care: Baseline findings from a cohort study. ( 29398125 )
2018
30
From hyperuricaemia to gout: what are the missing links? ( 29921940 )
2018
31
Assessing qualitatively the impact of gout on sleep: any sleep was a dream far away until the gout flare resolved. ( 29947811 )
2018
32
The diagnostic performance of musculoskeletal ultrasound in gout: A systematic review and meta-analysis. ( 29979706 )
2018
33
Metabolomics approach by <sup>1</sup>H NMR spectroscopy of serum reveals progression axes for asymptomatic hyperuricemia and gout. ( 29871692 )
2018
34
Gout as a risk factor for osteoporosis: epidemiologic evidence from a population-based longitudinal study involving 108,060 individuals. ( 29383389 )
2018
35
Lumbar Gout Tophus Mimicking Epidural Abscess with Magnetic Resonance Imaging, Bone, and Gallium Scans. ( 29643682 )
2018
36
Upper Extremity Compartment Syndrome in a Patient with Acute Gout Attack but without Trauma or Other Typical Causes. ( 29796328 )
2018
37
Coexisting Gout and Chondrocalcinosis on Hand Radiograph. ( 29717094 )
2018
38
Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies. ( 29976236 )
2018
39
Mediation analysis to understand genetic relationships between habitual coffee intake and gout. ( 29976226 )
2018
40
The Cost-effectiveness of Biannual Serum Urate (SU) Monitoring after Reaching Target in Gout: A Health Economic Analysis Comparing SU Monitoring. ( 29449500 )
2018
41
Hospitalization Increases the Risk of Acute Arthritic Flares in Gout: A Population-based Study over 2 Decades. ( 29961683 )
2018
42
Management of gout by UK rheumatologists: a British Society for Rheumatology national audit. ( 29447370 )
2018
43
Spinal gout causing reversible quadriparesis: a case report and literature review. ( 29915646 )
2018
44
Inpatient rheumatology consultation for gout flares and advice to initiate urate lowering treatment (ULT) in hospital discharge summary increases ULT prescription in primary care. ( 29966768 )
2018
45
A repeated carpal tunnel syndrome due to tophaceous gout in flexor tendon: A case report. ( 28248892 )
2017
46
Treatment of gout combined with KienbAPck's disease: A case report. ( 29067099 )
2017
47
Gout: Diagnosis and Management. ( 29431386 )
2017
48
Dietary Management of Gout: What is the Evidence? ( 27986240 )
2017
49
Lytic Bone Lesions: Osteomyelitis or Intraosseous Gout? ( 28864666 )
2017
50
Association of gout and depression: A systematic review and meta-analysis. ( 28921661 )
2017
Sources

Variations for Gout

About this section

ClinVar genetic disease variations for Gout:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DARS2 NM_018122.4(DARS2): c.228-21_228-20delTTinsC indel Pathogenic rs367543010 GRCh37 Chromosome 1, 173797450: 173797451
2 DARS2 NM_018122.4(DARS2): c.228-21_228-20delTTinsC indel Pathogenic rs367543010 GRCh38 Chromosome 1, 173828312: 173828313
3 DARS2 NM_018122.4(DARS2): c.492+2T> C single nucleotide variant Pathogenic rs142433332 GRCh37 Chromosome 1, 173800770: 173800770
4 DARS2 NM_018122.4(DARS2): c.492+2T> C single nucleotide variant Pathogenic rs142433332 GRCh38 Chromosome 1, 173831632: 173831632
Sources

Expression for Gout

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Search GEO for disease gene expression data for Gout.
Sources

Pathways for Gout

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Pathways related to Gout according to KEGG:

37
# Name Kegg Source Accession
1 Purine metabolism hsa00230

Pathways related to Gout according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Purine metabolism (KEGG) 22
Show member pathways
 12.22 ADSL APRT HPRT1 PRPS1 XDH
2
Purine metabolism (REACTOME) 1
Show member pathways
 11.97 ADSL APRT HPRT1 XDH
3
IL1 and megakaryocytes in obesity 1
10.8 IL1B NLRP3
4
Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics 61
10.76 HPRT1 PRPS1 XDH
5
Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics 61
10.67 ABCG2 SLC22A11
6
Nucleotide Metabolism 1
10.41 ADSL HPRT1 PRPS1
7
Uricosurics Pathway, Pharmacodynamics 61
10.18 ABCG2 SLC17A1 SLC17A3 SLC22A11 SLC22A12 SLC2A9
Sources

GO Terms for Gout

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Cellular components related to Gout according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.17