MCID: GRH005
MIFTS: 24

Graham-Little-Piccardi-Lassueur Syndrome

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Graham-Little-Piccardi-Lassueur Syndrome

MalaCards integrated aliases for Graham-Little-Piccardi-Lassueur Syndrome:

Name: Graham-Little-Piccardi-Lassueur Syndrome 20
Graham Little-Piccardi-Lassueur Syndrome 20 58
Piccardi-Lassueur-Little Syndrome 20 58
Graham Little Syndrome 20 58
Lichen Planus Follicularis 70

Characteristics:

Orphanet epidemiological data:

58
graham little-piccardi-lassueur syndrome
Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 via Orphanet 33 L66.1
Orphanet 58 ORPHA505
UMLS 70 C0023645

Summaries for Graham-Little-Piccardi-Lassueur Syndrome

GARD : 20 Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare type of scarring hair loss. It is most commonly found in otherwise healthy women between the ages of 30 and 70 years. GLPLS is characterized by three features: progressive patchy scarring hair loss of the scalp ( cicatricial alopecia ), non-scarring thinning of the hair in the armpits and groin (noncicatricial alopecia), and spiky rough bumps based around hair follicles ( follicular lichen planus ). Sometimes individuals with GLPLS experience itching around affected areas, which can be severe. The cause of this condition is not known; however, over the years, researchers have suggested theories that it may develop in relation to genetic factors, viral exposures, hormonal changes, immune system issues, stress, and vitamin deficiencies. Treatment focuses on slowing the progression of hair loss and may include corticosteroids, retinoids (medications related to vitamin A), psoralen plus ultraviolet light A (PUVA), antimalarial medications, and antibiotics.

MalaCards based summary : Graham-Little-Piccardi-Lassueur Syndrome, also known as graham little-piccardi-lassueur syndrome, is related to alopecia and frontal fibrosing alopecia. An important gene associated with Graham-Little-Piccardi-Lassueur Syndrome is HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha). Affiliated tissues include myeloid and pituitary, and related phenotypes are alopecia and sparse scalp hair

Related Diseases for Graham-Little-Piccardi-Lassueur Syndrome

Diseases related to Graham-Little-Piccardi-Lassueur Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 alopecia 10.9
2 frontal fibrosing alopecia 10.7
3 keratosis 10.7
4 androgen insensitivity syndrome 10.6
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
6 lichen planus 10.6
7 complete androgen insensitivity syndrome 10.4
8 pseudohermaphroditism 10.4
9 hypotrichosis 10.4
10 lichen planus pigmentosus 10.4
11 hypopituitarism 10.3
12 pustulosis of palm and sole 10.2
13 psoriasis 10.2
14 pityriasis rubra pilaris 10.0
15 cutaneous lupus erythematosus 10.0
16 alopecia areata 10.0
17 pustular psoriasis 10.0
18 chronic cutaneous lupus erythematosus 10.0

Graphical network of the top 20 diseases related to Graham-Little-Piccardi-Lassueur Syndrome:



Diseases related to Graham-Little-Piccardi-Lassueur Syndrome

Symptoms & Phenotypes for Graham-Little-Piccardi-Lassueur Syndrome

Human phenotypes related to Graham-Little-Piccardi-Lassueur Syndrome:

58 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 alopecia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001596
2 sparse scalp hair 58 31 hallmark (90%) Very frequent (99-80%) HP:0002209
3 sparse axillary hair 58 31 hallmark (90%) Very frequent (99-80%) HP:0002215
4 sparse pubic hair 58 31 hallmark (90%) Very frequent (99-80%) HP:0002225
5 perifollicular hyperkeratosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0007468
6 pruritus 58 31 frequent (33%) Frequent (79-30%) HP:0000989
7 lichenification 58 31 frequent (33%) Frequent (79-30%) HP:0100725

Drugs & Therapeutics for Graham-Little-Piccardi-Lassueur Syndrome

Search Clinical Trials , NIH Clinical Center for Graham-Little-Piccardi-Lassueur Syndrome

Genetic Tests for Graham-Little-Piccardi-Lassueur Syndrome

Anatomical Context for Graham-Little-Piccardi-Lassueur Syndrome

MalaCards organs/tissues related to Graham-Little-Piccardi-Lassueur Syndrome:

40
Myeloid, Pituitary

Publications for Graham-Little-Piccardi-Lassueur Syndrome

Articles related to Graham-Little-Piccardi-Lassueur Syndrome:

(show all 24)
# Title Authors PMID Year
1
Graham-Little-Piccardi-Lassueur syndrome in siblings. 61
33772755 2021
2
Clinical, Dermoscopic and In-Vivo Reflectance Confocal Microscopy Evaluation of a Case of Graham Little-Piccardi-Lassueur Syndrome Successfully Treated with Narrowband-UVB Phototherapy. 61
32533553 2020
3
Graham-Little-Piccardi-Lassueur Syndrome: Report of a Chinese Case with Hair Casts. 61
32684685 2020
4
Pediatric case of Graham Little Piccardi Lassueur syndrome - A rare entity. 61
31656251 2019
5
Lichen planopilaris: retrospective study on the characteristics and treatment of 291 patients. 61
30411987 2019
6
Graham-Little-Piccardi-Lassueur syndrome. 61
31233585 2019
7
Lichen planopilaris in a Latin American (Chilean) population: demographics, clinical profile and treatment experience. 61
28748570 2017
8
Lichenoid folliculitis: A unifying concept. 61
28345255 2017
9
Graham Little-Piccardi-Lassueur syndrome in a patient with androgen insensitivity syndrome. 61
26566966 2016
10
Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia. 61
26352467 2016
11
Lichen planopilaris epidemiology: a retrospective study of 80 cases. 61
26560212 2015
12
[Not Available]. 61
26436976 2015
13
Case for diagnosis. Lichen Planus. 61
25387513 2014
14
Lichen planopilaris: Epidemiology and prevalence of subtypes - a retrospective analysis in 104 patients. 61
24533855 2014
15
Lichen planopilaris: update on pathogenesis and treatment. 61
23930355 2013
16
Graham-Little Piccardi Lassueur syndrome: case report. 61
23044575 2012
17
Graham-Little-Piccardi-Lassueur syndrome. 61
22031656 2011
18
Graham-little piccardi lassueur syndrome: an unusual variant of follicular lichen planus. 61
21769233 2011
19
Graham-Little syndrome. 61
20976421 2010
20
Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. 61
17222351 2007
21
Graham Little-Piccardi-Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization). 61
15196163 2004
22
Graham Little-Piccardi-Lassueur syndrome: effective treatment with cyclosporin A. 61
11678880 2001
23
[Piccardi-Lassueur-Little syndrome]. 61
654531 1978
24
[Piccardi-Lassueur-Little syndrome; pathogenetic role of pituitary insufficiency]. 61
13203136 1954

Variations for Graham-Little-Piccardi-Lassueur Syndrome

Expression for Graham-Little-Piccardi-Lassueur Syndrome

Search GEO for disease gene expression data for Graham-Little-Piccardi-Lassueur Syndrome.

Pathways for Graham-Little-Piccardi-Lassueur Syndrome

GO Terms for Graham-Little-Piccardi-Lassueur Syndrome

Sources for Graham-Little-Piccardi-Lassueur Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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