MCID: GRN008
MIFTS: 20

Granular Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Granular Cell Carcinoma

MalaCards integrated aliases for Granular Cell Carcinoma:

Name: Granular Cell Carcinoma 12 15
Granular Cell Cancer 29 6
Granular Cell Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4903
MeSH 44 D000230
NCIt 50 C3681
SNOMED-CT 67 69028005
UMLS 70 C0205644

Summaries for Granular Cell Carcinoma

Disease Ontology : 12 A carcinoma that derives from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

MalaCards based summary : Granular Cell Carcinoma, also known as granular cell cancer, is related to oncocytoma and granular cell tumor. An important gene associated with Granular Cell Carcinoma is BRD7 (Bromodomain Containing 7). Affiliated tissues include thyroid, testis and kidney.

Related Diseases for Granular Cell Carcinoma

Diseases related to Granular Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 oncocytoma 10.0
2 granular cell tumor 9.9
3 chromophobe renal cell carcinoma 9.9
4 testis seminoma 9.9 PBOV1 HHLA1
5 thyroid gland follicular carcinoma 9.8 STT3A NIBAN1
6 papillary transitional carcinoma 9.5 PBOV1 HHLA1 CT47A5

Graphical network of the top 20 diseases related to Granular Cell Carcinoma:



Diseases related to Granular Cell Carcinoma

Symptoms & Phenotypes for Granular Cell Carcinoma

Drugs & Therapeutics for Granular Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Granular Cell Carcinoma

Genetic Tests for Granular Cell Carcinoma

Genetic tests related to Granular Cell Carcinoma:

# Genetic test Affiliating Genes
1 Granular Cell Cancer 29

Anatomical Context for Granular Cell Carcinoma

MalaCards organs/tissues related to Granular Cell Carcinoma:

40
Thyroid, Testis, Kidney

Publications for Granular Cell Carcinoma

Articles related to Granular Cell Carcinoma:

(show all 31)
# Title Authors PMID Year
1
Rectal Granular Cell Carcinoma Requiring Abdominoperineal Resection. 61
33745283 2021
2
[Clinical analysis of renal cell carcinoma: report of 271 cases]. 61
19035217 2008
3
Renal cell carcinoma in dialysis patients: a single center experience. 61
16903927 2006
4
[Renal cell carcinoma with bilateral adrenal and small intestinal metastases: a case report]. 61
16485557 2006
5
[Nephron-sparing surgery for localized kidney neoplasms--a report of 25 cases]. 61
16405755 2006
6
Resection of local recurrence of renal cell carcinoma in a hemodialysis patient 6 years after radical nephrectomy. 61
15242367 2004
7
[A case of complete regression of metastatic renal cell carcinoma following corticosteroid treatment]. 61
12784718 2003
8
Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. 61
11859199 2002
9
[A case of left renal cell carcinoma in a young male adult with left varicocele]. 61
10876755 2000
10
Analysis of CD44 isoform v10 expression and its prognostic value in renal cell carcinoma. 61
10691836 2000
11
Glassy hyaline globules in granular cell carcinoma, chromophobe cell carcinoma, and oncocytoma of the kidney. 61
9845718 1998
12
Oncocytic cells and parenchymal tumors of the kidney. 61
8766096 1996
13
Renal cell carcinoma and tumor thrombus neovascularity: MR demonstration with pathologic correlation. 61
8661564 1996
14
Aspiration cytology of chromophobe cell carcinoma of the kidney. 61
8599910 1995
15
Renal cell carcinoma in dialysis patients. 61
7801421 1994
16
[Establishment and characterization of a new human renal cell carcinoma cell line (KG-2) and metastatic model in nude mice]. 61
8345719 1993
17
DNA ploidy of oncocytic-granular renal cell carcinomas and renal oncocytomas by image analysis. 61
1733409 1992
18
Changes in glycolipids in human renal-cell carcinoma and their clinical significance. 61
1917130 1991
19
Cellular origin of renal cell carcinoma--an immunohistological study on monoclonal antibodies. 61
1785005 1991
20
[A clinico-pathological study of small renal cell carcinoma]. 61
2292822 1990
21
[The clinical significance of the morphological characteristics of kidney cancer in middle-aged and elderly subjects]. 61
2175961 1990
22
[An evaluation of urinary Tamm-Horsfall protein coating cell in the diagnosis of urologic neoplasms]. 61
2364814 1990
23
[Retrospective evaluation of the efficacy of regional endolymphatic polychemotherapy in kidney cancer depending on the histologic structure of the tumor]. 61
2505424 1989
24
Oncocytoma and low-grade oncocytic carcinoma of the kidney. 61
2714326 1989
25
[Clinico-morphological characteristics of renal-cell carcinoma]. 61
6084503 1984
26
Renal cell carcinoma: natural history and results of treatment. 61
660755 1978
27
Spectrum of ultrastructural patterns of renal cell adenocarcinoma. 61
841789 1977
28
[A case of oxyphilic granular cell carcinoma of the parotid gland, metastasizing to the lymph nodes (author's transl)]. 61
4802113 1973
29
[A histochemical contribution to the problem of oxyphilic granular cell carcinoma (malignant oncocytoma) in radium-treated "stages-tuberculosis" (scrophuloderma + lupus vulgaris)]. 61
4220798 1964
30
[Oxyphilic granular cell carcinoma (malignant onkocytoma) on roentgen-irradiated "stage tuberculosis" (scrofuloderma plus lupus vulgaris)]. 61
13992192 1963
31
Biological assay of human kidney tumors by means of heterologous ocular transplantations; a study of clear-cell carcinoma, granular-cell carcinoma and papilliferous epithelioma of the kidney. 61
20249372 1947

Variations for Granular Cell Carcinoma

ClinVar genetic disease variations for Granular Cell Carcinoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 BRD7 NM_013263.5(BRD7):c.1834C>T (p.Arg612Ter) SNV Likely pathogenic 208203 rs796065051 GRCh37: 16:50353864-50353864
GRCh38: 16:50319953-50319953
2 APC NM_000038.6(APC):c.7402T>C (p.Ser2468Pro) SNV Uncertain significance 184474 rs375586273 GRCh37: 5:112178693-112178693
GRCh38: 5:112842996-112842996

Expression for Granular Cell Carcinoma

Search GEO for disease gene expression data for Granular Cell Carcinoma.

Pathways for Granular Cell Carcinoma

GO Terms for Granular Cell Carcinoma

Sources for Granular Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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