MCID: GRN010
MIFTS: 45

Granular Cell Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Granular Cell Tumor

MalaCards integrated aliases for Granular Cell Tumor:

Name: Granular Cell Tumor 12 53 55 44 15 73
Granular Cell Carcinoma 12 15
Giant Granulocellular Abrikosov's Tumor 53
Malignant Variant of Abrikosov's Tumor 53
Abrikosoff's Granulous Cell Tumor 53
Granular Cell Adenocarcinoma 12
Neoplasm of Granular Cell 12
Carcinoma, Granular Cell 73
Abrikosoff's Tumor 53
Abrikosov's Tumor 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2411 DOID:4903
NCIt 50 C3474 C3681
SNOMED-CT 68 12169001 69028005

Summaries for Granular Cell Tumor

NIH Rare Diseases : 53 Granular celltumors(GCTs) are soft tissue tumors that can occur anywhere in the body. They are thought to arise from the cells that surround and insulate the nerve cells in our body (Schwann cells). Most granular cell tumors are benign (non-cancerous), although some may be locally aggressive. Less than 2% are malignant (cancerous), but these are aggressive and often are associated with a poor prognosis. GCTs affect females more often than males and usually present as a solitary painless mass. A few individuals have multiple GCTs. In most cases, these tumors are located in the skin of the head and neck, especially inside the mouth (70%), the tongue being the most common site. They may also occur in the breast, heart, pituitary gland, stomach, esophagus, genitalia, and upper respiratory tract. GCTs may be  part of some genetic syndromes, such as LEOPARD syndrome and neurofibromatosis. Complete surgical removal of the tumor is usually curative, but in some cases the tumors may recur.

MalaCards based summary : Granular Cell Tumor, also known as granular cell carcinoma, is related to skin granular cell tumor and congenital epulis. An important gene associated with Granular Cell Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. The drugs Ifosfamide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin.

Disease Ontology : 12 A carcinoma that derives from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

Wikipedia : 76 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Related Diseases for Granular Cell Tumor

Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 272)
# Related Disease Score Top Affiliating Genes
1 skin granular cell tumor 33.9 CD68 ENO2
2 congenital epulis 31.8 CD68 DES ENO2 UCHL1 VIM
3 epulis 30.7 DES ENO2 VIM
4 perineurioma 30.3 S100B VIM
5 alveolar soft part sarcoma 30.1 DES ENO2 VIM
6 spindle cell carcinoma 30.0 DES VIM
7 odontogenic myxoma 29.7 S100B SERPINA3 VIM
8 cystic teratoma 29.7 ENO2 GFAP
9 leiomyosarcoma 29.6 DES ENO2 S100B VIM
10 fibrous histiocytoma 29.5 DES S100B SERPINA3 VIM
11 malignant fibroxanthoma 29.5 DES S100B SERPINA3 VIM
12 gastrointestinal stromal tumor 29.5 DES ENO2 S100B UCHL1 VIM
13 neurilemmoma 29.1 DES ENO2 GFAP S100B VIM
14 congenital granular cell tumor 12.4
15 vulvar granular cell tumor 12.4
16 malignant gastric granular cell tumor 12.3
17 breast granular cell tumor 12.3
18 neurohypophysis granular cell tumor 12.2
19 malignant granular cell myoblastoma 11.9
20 mediastinal granular cell myoblastoma 11.7
21 cardiac granular cell neoplasm 11.7
22 myoblastoma 11.6
23 malignant granular cell esophageal tumor 11.5
24 cowden syndrome 1 11.3
25 malignant granular cell skin tumor 11.3
26 adenocarcinoma 10.3
27 rhabdoid tumor predisposition syndrome 1 10.2 DES VIM
28 muscle cancer 10.2 DES ENO2
29 squamous cell carcinoma 10.2
30 papillary tumor of the pineal region 10.2 ENO2 VIM
31 infantile digital fibromatosis 10.2 DES VIM
32 fibromatosis 10.2 DES VIM
33 lymphangiomatosis 10.2 DES VIM
34 angiolipoma 10.2 DES VIM
35 spindle cell lipoma 10.2 DES VIM
36 benign metastasizing leiomyoma 10.2 DES VIM
37 malignant ectomesenchymoma 10.2 DES ENO2
38 ectomesenchymoma 10.2 DES ENO2
39 biphasic synovial sarcoma 10.2 DES VIM
40 pilomatrixoma 10.2 ENO2 S100B
41 secondary progressive multiple sclerosis 10.2 ENO2 S100B
42 extraosseous ewing's sarcoma 10.2 ENO2 S100B
43 clear cell sarcoma 10.2 ENO2 S100B
44 acute mountain sickness 10.2 ENO2 S100B
45 cystic nephroma 10.2 DES VIM
46 hydromyelia 10.2 S100B VIM
47 adenofibroma 10.2 INHA VIM
48 microcystic adenoma 10.2 ENO2 INHA
49 perivascular epithelioid cell tumor 10.2 DES VIM
50 primary hepatic neuroendocrine carcinoma 10.2 S100B VIM

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to Granular Cell Tumor

Symptoms & Phenotypes for Granular Cell Tumor

Drugs & Therapeutics for Granular Cell Tumor

Drugs for Granular Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 6055-19-2, 50-18-0 2907
3
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
4
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Anti-Bacterial Agents Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Topoisomerase Inhibitors Phase 2, Phase 3
10 Alkylating Agents Phase 2, Phase 3
11 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Granular Cell Tumor

Cochrane evidence based reviews: granular cell tumor

Genetic Tests for Granular Cell Tumor

Anatomical Context for Granular Cell Tumor

MalaCards organs/tissues related to Granular Cell Tumor:

41
Breast, Tongue, Skin, Pituitary, Heart, Colon, Thyroid

Publications for Granular Cell Tumor

Articles related to Granular Cell Tumor:

(show top 50) (show all 887)
# Title Authors Year
1
Granular cell tumor of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration. ( 29380119 )
2018
2
Ultrasonographic manifestations of a rare granular cell tumor of the accessory breast: A case report. ( 29505520 )
2018
3
Synchronous gastric leiomyoma and intramuscular abdominal wall granular cell tumor with similar imaging features: A case report. ( 29529541 )
2018
4
Oral Granular Cell Tumor Mimicking a Giant Sialolith in a Child. ( 29336800 )
2018
5
Granular cell tumor of the breast: Molecular pathology and clinical management. ( 29900629 )
2018
6
Primary malignant perivascular epithelioid cell neoplasm (PEComa) of the bone mimicking granular cell tumor in core biopsy: A case report and literature review. ( 29435023 )
2018
7
Cytological and histological correlation of granular cell tumor in a series of three cases. ( 29516941 )
2018
8
Colonic Granular Cell Tumor: An Endoscopic and Histopathologic Review with Case Illustration. ( 29531868 )
2018
9
Dermal non-neural granular cell tumor in a 3-year-old child. ( 29766548 )
2018
10
Granular cell tumor in axillary region: A rare entity. ( 29541467 )
2018
11
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital. ( 29548015 )
2018
12
Intramuscular granular cell tumor of the gluteal region. ( 29423168 )
2018
13
A Tale of Two Tumors: a Case of Concomitant Esophageal Squamous Papilloma and Granular Cell Tumor. ( 29453760 )
2018
14
Granular cell tumor experience at a comprehensive cancer center. ( 29661274 )
2018
15
Coexisting Granular Cell Tumor and Tubular Adenoma of the Ileocecal Valve. ( 29515339 )
2018
16
18F-FDG PET/CT and MRI of a Mediastinal Malignant Granular Cell Tumor With Associated Recurrent Pericarditis. ( 29847320 )
2018
17
Malignant granular cell tumor of the median nerve: a case report with a literature review of 157 cases. ( 29980826 )
2018
18
Clinical and imaging features of granular cell tumor of the neurohypophysis: A retrospective analysis. ( 29489677 )
2018
19
Congenital granular cell tumor of the newborn - Spontaneous regression or early surgical intervention. ( 30246757 )
2018
20
Congenital Granular Cell Tumor: Case Report and Review. ( 30356466 )
2018
21
Esophageal Granular Cell Tumor in a 28-year-old: A Unique Cause for Dysphagia. ( 30050734 )
2018
22
Incidental Finding of Granular Cell Tumor in the Ileocecal Valve During Colectomy for Adenocarcinoma. ( 28187037 )
2018
23
Progressive loss of supination of the wrist. Benign intramuscular granular cell tumor (also known as Abrikossoff’s tumor) of the right wrist. ( 28762095 )
2018
24
Gastrointestinal and biliary granular cell tumor: diagnosis and management. ( 29991888 )
2018
25
Colonic granular cell tumor: Report of 11 cases and management with review of the literature. ( 30008819 )
2018
26
Granular Cell Tumor of the Neurohypophysis: 3 Cases and a Systematic Literature Review of 98 Cases. ( 30017767 )
2018
27
A Case of Symptomatic Granular Cell Tumor of the Pituitary Treated with Stereotactic Radiosurgery. ( 30045031 )
2018
28
Granular Cell Tumor Imaging Using Optical Coherence Tomography. ( 30116105 )
2018
29
Metachronous Granular Cell Tumor of the Descending Colon. ( 30116432 )
2018
30
Granular cell tumor of the infundibulum: a systematic review of MR-radiography, pathology, and clinical findings. ( 30141059 )
2018
31
Granular Cell Tumor of the Bladder: A Report of Six Cases. ( 30170086 )
2018
32
Malignant granular cell tumor: Clinical features and long-term survival. ( 30196562 )
2018
33
Granular cell tumor: A report of three cases and review of literature. ( 30223384 )
2018
34
Granular cell tumor in a premenstrual female breast. ( 30241035 )
2018
35
Granular Cell Tumor Located in the Bulbar Subconjunctival Space. ( 30320087 )
2018
36
A Granular Cell Tumor Appearing at a Vaccination Site, a Possible Reaction to Trauma? ( 30371513 )
2018
37
Rare granular cell tumor affecting a 13-year-old boy. ( 30409955 )
2018
38
Gastric granular cell tumor in a youth excised by endoscopic submucosal dissection : A case report and literature review. ( 29560700 )
2017
39
Granular cell tumor of the urinary bladder. ( 28861316 )
2017
40
Extent of surgical resection and tumor size predicts prognosis in granular cell tumor of the sellar region. ( 28948361 )
2017
41
Coexistent Squamous Cell Carcinoma and Granular Cell Tumor of Head and Neck Region: Report of Two Very Rare Cases and Review of the Literature. ( 28783989 )
2017
42
Pleural-based granular cell tumor. ( 28670071 )
2017
43
Recurrent granular cell tumor: a case report and review of literature. ( 29057362 )
2017
44
Granular Cell Tumor of Cecum: A Common Tumor in a Rare Site with Diagnostic Challenge. ( 28975016 )
2017
45
Eosinophilic Esophagitis and Esophageal Granular Cell Tumor: An Unexpected Association. ( 28296675 )
2017
46
Congenital Non-Neural Granular Cell Tumor Mimicking Nevus Lipomatosus Superficialis. ( 29200768 )
2017
47
Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature. ( 29271018 )
2017
48
A Case of Granular Cell Tumor of the Clitoris in a Postmenopausal Woman. ( 28951863 )
2017
49
Intraorbital Granular Cell Tumor Involving in Medial Rectus and Optic Nerve. ( 28639585 )
2017
50
Granular cell tumor in breast: a case report. ( 28442932 )
2017

Variations for Granular Cell Tumor

Cosmic variations for Granular Cell Tumor:

9 (show top 50) (show all 82)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10662 TP53 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
2 COSM607136 TGFBR1 skin,neck,carcinoma,NS c.1247C>T p.S416F 9:99146601-99146601 6
3 COSM6962965 SMO skin,neck,carcinoma,NS c.1103C>T p.P368L 7:129206332-129206332 6
4 COSM6962990 RARA skin,neck,carcinoma,NS c.1384C>T p.P462S 17:40356221-40356221 6
5 COSM6962984 RAD52 skin,neck,carcinoma,NS c.439G>A p.V147M 12:927173-927173 6
6 COSM6962994 PTPRT skin,neck,carcinoma,NS c.1607C>T p.S536L 20:42352239-42352239 6
7 COSM6962992 PTPRT skin,neck,carcinoma,NS c.1619G>A p.G540E 20:42352227-42352227 6
8 COSM6962970 PTPRD skin,neck,carcinoma,NS c.1736G>A p.S579N 9:8504347-8504347 6
9 COSM456125 PTPRD skin,neck,carcinoma,NS c.5048C>T p.S1683F 9:8341168-8341168 6
10 COSM1700914 PTPRD skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6
11 COSM17483 PTCH1 skin,neck,carcinoma,NS c.1729-1G>T p.? 9:95469932-95469932 6
12 COSM17468 PTCH1 skin,neck,carcinoma,NS c.584G>T p.R195M 9:95485685-95485685 6
13 COSM29053 PTCH1 skin,neck,carcinoma,NS c.833G>A p.W278* 9:95480502-95480502 6
14 COSM29072 PTCH1 skin,neck,carcinoma,NS c.1067+1G>A p.? 9:95479968-95479968 6
15 COSM14452 PTCH1 skin,neck,carcinoma,NS c.2321G>A p.G774E 9:95467355-95467355 6
16 COSM6962989 PLCG2 skin,neck,carcinoma,NS c.115G>T p.E39* 16:81786104-81786104 6
17 COSM6962963 PIK3CG skin,neck,carcinoma,NS c.310G>A p.G104R 7:106867871-106867871 6
18 COSM6962964 PIK3CG skin,neck,carcinoma,NS c.3227G>A p.R1076K 7:106905305-106905305 6
19 COSM564 NRAS skin,neck,carcinoma,NS c.35G>A p.G12D 1:114716126-114716126 6
20 COSM6962996 NCOA3 skin,neck,carcinoma,NS c.979C>T p.H327Y 20:47634062-47634062 6
21 COSM4170532 MTOR skin,neck,carcinoma,NS c.3409G>A p.E1137K 1:11212464-11212464 6
22 COSM516 KRAS skin,neck,carcinoma,NS c.34G>T p.G12C 12:25245351-25245351 6
23 COSM6962967 KMT2C skin,neck,carcinoma,NS c.11659C>T p.H3887Y 7:152158874-152158874 6
24 COSM6962983 KMT2A skin,neck,carcinoma,NS c.4377T>G p.C1459W 11:118488658-118488658 6
25 COSM498 HRAS skin,neck,carcinoma,NS c.182A>T p.Q61L 11:533874-533874 6
26 COSM6438927 HGF skin,neck,carcinoma,NS c.974C>T p.P325L 7:81729671-81729671 6
27 COSM6962960 FGFR3 skin,neck,carcinoma,NS c.2421A>G p.*807W 4:1807262-1807262 6
28 COSM6962980 FGFR2 skin,neck,carcinoma,NS c.2234C>T p.S745F 10:121483765-121483765 6
29 COSM6962962 EPHA7 skin,neck,carcinoma,NS c.2468G>A p.G823E 6:93254711-93254711 6
30 COSM5918388 EPHA5 skin,neck,carcinoma,NS c.2608G>A p.E870K 4:65348104-65348104 6
31 COSM6962957 EPHA3 skin,neck,carcinoma,NS c.632T>A p.M211K 3:89210338-89210338 6
32 COSM6946976 EPHA3 skin,neck,carcinoma,NS c.533G>A p.G178E 3:89210239-89210239 6
33 COSM6962956 CASP8 skin,neck,carcinoma,NS c.1382C>T p.T461I 2:201286485-201286485 6
34 COSM3713589 CASP8 skin,neck,carcinoma,NS c.1093C>T p.L365F 2:201285055-201285055 6
35 COSM21323 ATM skin,neck,carcinoma,NS c.1009C>T p.R337C 11:108247071-108247071 6
36 COSM6950941 APC skin,neck,carcinoma,NS c.536C>T p.S179F 5:112780794-112780794 6
37 COSM6962953 AKT3 skin,neck,carcinoma,NS c.1164-1G>A p.? 1:243545598-243545598 6
38 COSM6962993 skin,neck,carcinoma,NS c.1619G>A p.G540E 20:42352227-42352227 6
39 COSM1640830 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
40 COSM6962974 skin,neck,carcinoma,NS c.1231C>T p.P411S 9:8518130-8518130 6
41 COSM6962968 skin,neck,carcinoma,NS c.1736G>A p.S579N 9:8504347-8504347 6
42 COSM6962949 skin,neck,carcinoma,NS c.493C>T p.P165S 1:77966737-77966737 6
43 COSM6962972 skin,neck,carcinoma,NS c.1727G>A p.S576N 9:8504347-8504347 6
44 COSM6962978 skin,neck,carcinoma,NS c.2237C>T p.S746F 10:121483765-121483765 6
45 COSM6962995 skin,neck,carcinoma,NS c.1607C>T p.S536L 20:42352239-42352239 6
46 COSM1350749 skin,neck,carcinoma,NS c.1009C>T p.R337C 11:108247071-108247071 6
47 COSM6962951 skin,neck,carcinoma,NS c.1164-1G>A p.? 1:243545598-243545598 6
48 COSM1700913 skin,neck,carcinoma,NS c.1261C>T p.P421S 9:8518130-8518130 6
49 COSM1700915 skin,neck,carcinoma,NS c.1252C>T p.P418S 9:8518130-8518130 6
50 COSM6962982 skin,neck,carcinoma,NS c.4377T>G p.C1459W 11:118488658-118488658 6

Expression for Granular Cell Tumor

Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for Granular Cell Tumor

Pathways related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 GFAP S100B UCHL1
2
Show member pathways
11.37 DES GFAP VIM
3
Show member pathways
10.91 DES VIM
4 10.7 GFAP S100B VIM

GO Terms for Granular Cell Tumor

Cellular components related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.33 DES GFAP VIM
2 intermediate filament cytoskeleton GO:0045111 9.32 DES GFAP
3 photoreceptor inner segment GO:0001917 9.26 ENO2 INHA
4 myelin sheath GO:0043209 9.13 ENO2 GFAP UCHL1
5 neuronal cell body GO:0043025 8.92 ENO2 INHA S100B UCHL1

Biological processes related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.37 GFAP S100B
2 muscle filament sliding GO:0030049 9.32 DES VIM
3 astrocyte development GO:0014002 9.26 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
5 intermediate filament-based process GO:0045103 8.96 GFAP VIM
6 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Granular Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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