MCID: GRN010
MIFTS: 45

Granular Cell Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Granular Cell Tumor

MalaCards integrated aliases for Granular Cell Tumor:

Name: Granular Cell Tumor 12 54 56 45 15 17 74
Giant Granulocellular Abrikosov's Tumor 54
Malignant Variant of Abrikosov's Tumor 54
Abrikosoff's Granulous Cell Tumor 54
Neoplasm of Granular Cell 12
Carcinoma, Granular Cell 74
Abrikosoff's Tumor 54
Abrikosov's Tumor 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2411
MeSH 45 D016586
NCIt 51 C3474
SNOMED-CT 69 12169001

Summaries for Granular Cell Tumor

NIH Rare Diseases : 54 Granular celltumors(GCTs) are soft tissue tumors that can occur anywhere in the body. They are thought to arise from the cells that surround and insulate the nerve cells in our body (Schwann cells). Most granular cell tumors are benign (non-cancerous), although some may be locally aggressive. Less than 2% are malignant (cancerous), but these are aggressive and often are associated with a poor prognosis. GCTs affect females more often than males and usually present as a solitary painless mass. A few individuals have multiple GCTs. In most cases, these tumors are located in the skin of the head and neck, especially inside the mouth (70%), the tongue being the most common site. They may also occur in the breast, heart, pituitary gland, stomach, esophagus, genitalia, and upper respiratory tract. GCTs may be  part of some genetic syndromes, such as LEOPARD syndrome and neurofibromatosis. Complete surgical removal of the tumor is usually curative, but in some cases the tumors may recur.

MalaCards based summary : Granular Cell Tumor, also known as giant granulocellular abrikosov's tumor, is related to skin granular cell tumor and congenital epulis. An important gene associated with Granular Cell Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. The drugs Doxorubicin and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin.

Wikipedia : 77 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Related Diseases for Granular Cell Tumor

Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 skin granular cell tumor 34.1 CD68 ENO2
2 congenital epulis 32.3 CD68 DES ENO2 UCHL1 VIM
3 epulis 30.8 DES ENO2 VIM
4 perineurioma 30.4 S100B VIM
5 spindle cell carcinoma 30.3 DES VIM
6 alveolar soft part sarcoma 30.2 DES ENO2 VIM
7 odontogenic myxoma 29.7 S100B SERPINA3 VIM
8 cystic teratoma 29.7 ENO2 GFAP
9 leiomyosarcoma 29.6 DES ENO2 S100B VIM
10 cutaneous fibrous histiocytoma 29.4 DES S100B SERPINA3 VIM
11 fibrous histiocytoma 29.4 DES S100B SERPINA3 VIM
12 malignant fibroxanthoma 29.4 DES S100B SERPINA3 VIM
13 gastrointestinal stromal tumor 29.2 DES ENO2 S100B UCHL1 VIM
14 neurilemmoma 29.2 DES ENO2 GFAP S100B VIM
15 congenital granular cell tumor 12.4
16 neurohypophysis granular cell tumor 12.4
17 vulvar granular cell tumor 12.4
18 malignant gastric granular cell tumor 12.3
19 breast granular cell tumor 12.3
20 malignant granular cell myoblastoma 11.9
21 mediastinal granular cell myoblastoma 11.7
22 cardiac granular cell neoplasm 11.7
23 cowden syndrome 1 11.7
24 myoblastoma 11.6
25 malignant granular cell esophageal tumor 11.5
26 malignant granular cell skin tumor 11.4
27 rhabdoid tumor predisposition syndrome 1 10.4 DES VIM
28 cavernous hemangioma 10.4 DES VIM
29 muscle cancer 10.4 DES ENO2
30 papillary tumor of the pineal region 10.4 ENO2 VIM
31 infantile digital fibromatosis 10.4 DES VIM
32 fibromatosis 10.4 DES VIM
33 lymphangiomatosis 10.4 DES VIM
34 angiolipoma 10.3 DES VIM
35 spindle cell lipoma 10.3 DES VIM
36 benign metastasizing leiomyoma 10.3 DES VIM
37 malignant ectomesenchymoma 10.3 DES ENO2
38 ectomesenchymoma 10.3 DES ENO2
39 biphasic synovial sarcoma 10.3 DES VIM
40 pilomatrixoma 10.3 ENO2 S100B
41 secondary progressive multiple sclerosis 10.3 ENO2 S100B
42 extraosseous ewing's sarcoma 10.3 ENO2 S100B
43 clear cell sarcoma 10.3 ENO2 S100B
44 acute mountain sickness 10.3 ENO2 S100B
45 cystic nephroma 10.3 DES VIM
46 hydromyelia 10.3 S100B VIM
47 microcystic adenoma 10.3 ENO2 INHA
48 adenofibroma 10.3 INHA VIM
49 perivascular epithelioid cell tumor 10.3 DES VIM
50 primary hepatic neuroendocrine carcinoma 10.3 S100B VIM

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to Granular Cell Tumor

Symptoms & Phenotypes for Granular Cell Tumor

Drugs & Therapeutics for Granular Cell Tumor

Drugs for Granular Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6
Doxil Approved June 1999 Phase 2, Phase 3 31703
7 Topoisomerase Inhibitors Phase 2, Phase 3
8 Antineoplastic Agents, Alkylating Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3
11 Alkylating Agents Phase 2, Phase 3
12
Isophosphamide mustard Phase 2, Phase 3 0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride

Search NIH Clinical Center for Granular Cell Tumor

Cochrane evidence based reviews: granular cell tumor

Genetic Tests for Granular Cell Tumor

Anatomical Context for Granular Cell Tumor

MalaCards organs/tissues related to Granular Cell Tumor:

42
Breast, Tongue, Skin, Pituitary, Heart, Thyroid, Colon

Publications for Granular Cell Tumor

Articles related to Granular Cell Tumor:

(show top 50) (show all 904)
# Title Authors Year
1
Malignant granular cell tumor of the median nerve: a case report with a literature review of 157 cases. ( 29980826 )
2019
2
Granular cell tumor presenting as an intraocular mass: a case report. ( 31023279 )
2019
3
Granular Cell Tumor of the Bile Duct. ( 31069639 )
2019
4
Metastasizing Malignant Granular Cell Tumor (Abrikossoff Tumor) of the Anterior Abdominal Wall, with Prolonged Survival. ( 31080684 )
2019
5
Granular cell tumor of the trunk of the facial nerve: A case report. ( 31083267 )
2019
6
Benign Granular Cell Tumor of the Cecum. ( 31019852 )
2019
7
Granular cell tumor: The Great Mimicker. ( 30955209 )
2019
8
Granular Cell Tumor of the Perianal Region. ( 30820800 )
2019
9
Endoscopic submucosal dissection of an esophageal granular cell tumor. ( 30766943 )
2019
10
S100 negative granular cell tumor of the oral cavity: dermoscopy and surgical approach. ( 30726468 )
2019
11
Pancreatic granular cell tumor diagnosed by endoscopic ultrasound-guided fine needle aspiration biopsy. ( 30725445 )
2019
12
Metastatic granular cell tumor to the breast diagnosed by fine needle aspiration cytology: A case report with review of the literature. ( 30589232 )
2019
13
Coexisting Granular Cell Tumor and Tubular Adenoma of the Ileocecal Valve. ( 29515339 )
2018
14
Congenital granular cell tumor of the newborn - Spontaneous regression or early surgical intervention. ( 30246757 )
2018
15
Congenital Granular Cell Tumor: Case Report and Review. ( 30356466 )
2018
16
Esophageal Granular Cell Tumor in a 28-year-old: A Unique Cause for Dysphagia. ( 30050734 )
2018
17
Synchronous gastric leiomyoma and intramuscular abdominal wall granular cell tumor with similar imaging features: A case report. ( 29529541 )
2018
18
Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature. ( 29271018 )
2018
19
Oral Granular Cell Tumor Mimicking a Giant Sialolith in a Child. ( 29336800 )
2018
20
Granular cell tumor of the pancreas diagnosed by endoscopic ultrasound-guided fine-needle aspiration. ( 29380119 )
2018
21
Intramuscular granular cell tumor of the gluteal region. ( 29423168 )
2018
22
Primary malignant perivascular epithelioid cell neoplasm (PEComa) of the bone mimicking granular cell tumor in core biopsy: A case report and literature review. ( 29435023 )
2018
23
A Tale of Two Tumors: a Case of Concomitant Esophageal Squamous Papilloma and Granular Cell Tumor. ( 29453760 )
2018
24
Clinical and imaging features of granular cell tumor of the neurohypophysis: A retrospective analysis. ( 29489677 )
2018
25
Ultrasonographic manifestations of a rare granular cell tumor of the accessory breast: A case report. ( 29505520 )
2018
26
Cytological and histological correlation of granular cell tumor in a series of three cases. ( 29516941 )
2018
27
Colonic Granular Cell Tumor: An Endoscopic and Histopathologic Review with Case Illustration. ( 29531868 )
2018
28
Granular cell tumor in axillary region: A rare entity. ( 29541467 )
2018
29
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital. ( 29548015 )
2018
30
Granular cell tumor experience at a comprehensive cancer center. ( 29661274 )
2018
31
Dermal non-neural granular cell tumor in a 3-year-old child. ( 29766548 )
2018
32
18F-FDG PET/CT and MRI of a Mediastinal Malignant Granular Cell Tumor With Associated Recurrent Pericarditis. ( 29847320 )
2018
33
Granular cell tumor of the breast: Molecular pathology and clinical management. ( 29900629 )
2018
34
Gastrointestinal and biliary granular cell tumor: diagnosis and management. ( 29991888 )
2018
35
Granular cell tumor of the lung. ( 30582298 )
2018
36
A granular cell tumor: an unusual colon polyp. ( 30561220 )
2018
37
Cutaneous granular cell tumor clinically mimicking ectopic breast diagnosed on fine needle aspiration cytology. ( 30561159 )
2018
38
Granular cell tumor of the breast mimicking malignancy: a case report with a literature review. ( 30559976 )
2018
39
Case report: an intriguing sign in a patient with an inferior rectus muscle granular cell tumor. ( 30558046 )
2018
40
Rare granular cell tumor affecting a 13-year-old boy. ( 30409955 )
2018
41
A Granular Cell Tumor Appearing at a Vaccination Site, a Possible Reaction to Trauma? ( 30371513 )
2018
42
Granular Cell Tumor Located in the Bulbar Subconjunctival Space. ( 30320087 )
2018
43
Granular cell tumor in a premenstrual female breast. ( 30241035 )
2018
44
Granular cell tumor: A report of three cases and review of literature. ( 30223384 )
2018
45
Malignant granular cell tumor: Clinical features and long-term survival. ( 30196562 )
2018
46
Granular Cell Tumor of the Bladder: A Report of Six Cases. ( 30170086 )
2018
47
Granular cell tumor of the infundibulum: a systematic review of MR-radiography, pathology, and clinical findings. ( 30141059 )
2018
48
Metachronous Granular Cell Tumor of the Descending Colon. ( 30116432 )
2018
49
Granular Cell Tumor Imaging Using Optical Coherence Tomography. ( 30116105 )
2018
50
A Case of Symptomatic Granular Cell Tumor of the Pituitary Treated with Stereotactic Radiosurgery. ( 30045031 )
2018

Variations for Granular Cell Tumor

Expression for Granular Cell Tumor

Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for Granular Cell Tumor

Pathways related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 GFAP S100B UCHL1
2
Show member pathways
11.37 DES GFAP VIM
3
Show member pathways
10.91 DES VIM
4 10.7 GFAP S100B VIM

GO Terms for Granular Cell Tumor

Cellular components related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.26 DES GFAP
2 photoreceptor inner segment GO:0001917 9.16 ENO2 INHA
3 intermediate filament GO:0005882 9.13 DES GFAP VIM
4 neuronal cell body GO:0043025 8.92 ENO2 INHA S100B UCHL1

Biological processes related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-term synaptic potentiation GO:0060291 9.37 GFAP S100B
2 muscle filament sliding GO:0030049 9.32 DES VIM
3 astrocyte development GO:0014002 9.26 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
5 intermediate filament-based process GO:0045103 8.96 GFAP VIM
6 intermediate filament organization GO:0045109 8.8 DES GFAP VIM

Molecular functions related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.8 DES GFAP VIM

Sources for Granular Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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