MCID: GRN010
MIFTS: 42

Granular Cell Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Granular Cell Tumor

MalaCards integrated aliases for Granular Cell Tumor:

Name: Granular Cell Tumor 12 52 54 43 15 17 71
Abrikosov's Tumor 52 71
Giant Granulocellular Abrikosov's Tumor 52
Malignant Variant of Abrikosov's Tumor 52
Abrikosoff's Granulous Cell Tumor 52
Neoplasm of Granular Cell 12
Carcinoma, Granular Cell 71
Abrikosoff's Tumor 52

Classifications:



External Ids:

Disease Ontology 12 DOID:2411
MeSH 43 D016586
NCIt 49 C3474
SNOMED-CT 67 12169001 404035005
UMLS 71 C0085167 C0205644 C2930931

Summaries for Granular Cell Tumor

NIH Rare Diseases : 52 Granular cell tumors (GCTs) are soft tissue tumors that can occur anywhere in the body. They are thought to arise from the cells that surround and insulate the nerve cells in our body (Schwann cells ). Most granular cell tumors are benign (non-cancerous), although some may be locally aggressive. Less than 2% are malignant (cancerous), but these are aggressive and often are associated with a poor prognosis . GCTs a ffect females more often than males and usually present as a solitary painless mass. A few individuals have multiple GCTs. In most cases, these tumors are located in the skin of the head and neck, especially inside the mouth (70%), the tongue being the most common site. They may also occur in the breast, heart, pituitary gland , stomach, esophagus, genitalia, and upper respiratory tract. GCTs may be part of some genetic syndromes , such as LEOPARD syndrome and neurofibromatosis . Complete surgical removal of the tumor is usually curative, but in some cases the tumors may recur.

MalaCards based summary : Granular Cell Tumor, also known as abrikosov's tumor, is related to skin granular cell tumor and congenital granular cell tumor. An important gene associated with Granular Cell Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs Formaldehyde and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin, and related phenotypes are behavior/neurological and normal

Wikipedia : 74 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Related Diseases for Granular Cell Tumor

Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 634)
# Related Disease Score Top Affiliating Genes
1 skin granular cell tumor 34.5 ENO2 CD68
2 congenital granular cell tumor 34.5 ENO2 CD68
3 congenital epulis 32.9 VIM SERPINA3 ENO2 DES CD68
4 malignant granular cell myoblastoma 32.8 SERPINA3 MLANA ENO2 CD68
5 myoblastoma 32.6 SYP ENO2 CD68 CALB2
6 leiomyoma 30.7 VIM S100A1 DES
7 pleomorphic lipoma 30.7 SERPINA3 CD68
8 exophthalmos 30.7 SYP ENO2 CD68
9 epulis 30.6 VIM SERPINA3 ENO2 DES CD68
10 lipomatosis, multiple 30.4 SERPINA3 MLANA DES
11 epidermoid cysts 30.3 S100B S100A1
12 mesenchymal cell neoplasm 30.2 SERPINA3 MLANA CD68
13 secretory meningioma 30.2 VIM SERPINA3
14 meningioma, radiation-induced 30.2 VIM S100B GFAP
15 connective tissue benign neoplasm 30.1 SERPINA3 MLANA ENO2 CD68 CALB2
16 alveolar soft part sarcoma 30.1 VIM SYP ENO2 DES
17 perineurioma 30.1 VIM S100B S100A1 GFAP
18 skin benign neoplasm 30.0 SERPINA3 MLANA ENO2 CD68
19 spindle cell sarcoma 30.0 VIM SERPINA3 S100B DES
20 small cell carcinoma 29.9 SYP NKX2-1 ENO2
21 neurofibroma 29.9 VIM SYP S100B S100A1 MLANA
22 odontogenic myxoma 29.9 VIM SERPINA3 S100B
23 neuroendocrine tumor 29.9 SYP NKX2-1 ENO2
24 leydig cell tumor 29.9 SYP INHA CALB2
25 ganglioneuroblastoma 29.8 SYP S100B ENO2
26 hemangioma 29.8 SYP NKX2-1 ENO2 CD68
27 cutaneous leiomyosarcoma 29.7 VIM S100B GFAP DES
28 spindle cell carcinoma 29.7 VIM SYP ENO2 DES
29 oncocytoma 29.6 VIM SYP S100A1 NKX2-1
30 fibroma 29.6 VIM SERPINA3 S100A1 DES CD68 CALB2
31 epithelioid sarcoma 29.6 VIM SYP CD68 CALB2
32 paraganglioma 29.6 SYP S100B GFAP ENO2
33 congenital fibrosarcoma 29.5 VIM SERPINA3 S100A1 DES
34 carcinoid tumors, intestinal 29.5 SYP NKX2-1 ENO2
35 lung benign neoplasm 29.5 SYP NKX2-1 ENO2
36 ganglioneuroma 29.4 SYP S100B GFAP ENO2
37 ewing sarcoma 29.4 VIM SYP S100B ENO2 DES
38 malignant fibrous histiocytoma 29.3 VIM SERPINA3 S100B DES CD68
39 sarcoma 29.3 VIM SERPINA3 S100B S100A1 ENO2 DES
40 fibrous histiocytoma 29.3 VIM SERPINA3 S100B ENO2 DES CD68
41 mucoepidermoid carcinoma 29.2 SERPINA3 S100A1 NKX2-1
42 benign teratoma 29.2 SYP NKX2-1 ENO2 CALB2
43 neuroma 29.1 SERPINA3 S100B GFAP ENO2 CD68
44 papillary carcinoma 29.0 SYP S100A1 NKX2-1 CALB2
45 leiomyosarcoma 29.0 VIM SERPINA3 S100B S100A1 MLANA ENO2
46 cutaneous fibrous histiocytoma 28.9 VIM SERPINA3 S100B S100A1 MLANA DES
47 cystic teratoma 28.9 SYP NKX2-1 GFAP ENO2 CALB2
48 gastrointestinal stromal tumor 28.9 VIM UCHL1 SYP S100B S100A1 ENO2
49 renal cell carcinoma, nonpapillary 28.8 VIM S100A1 NKX2-1 ENO2 CALB2
50 teratoma 28.8 VIM SYP NKX2-1 GFAP ENO2 CALB2

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to Granular Cell Tumor

Symptoms & Phenotypes for Granular Cell Tumor

MGI Mouse Phenotypes related to Granular Cell Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 CALB2 DES ENO2 GFAP MBP NKX2-1
2 normal MP:0002873 9.23 CALB2 GFAP INHA MBP NKX2-1 S100A1

Drugs & Therapeutics for Granular Cell Tumor

Drugs for Granular Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved Phase 3 50-00-0 712
2
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
3
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
4
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
5
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
6
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
7 Alkylating Agents Phase 2, Phase 3
8
Liposomal doxorubicin Phase 2, Phase 3 31703
9 Anti-Bacterial Agents Phase 2, Phase 3
10
Isophosphamide mustard Phase 2, Phase 3 0
11 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endoscopic Ultrasonography Guided Fine Needle Biopsy (EUS-FNB) vs. Single-incision Needle-knife (SINK) Biopsy for Diagnosis of Upper Gastrointestinal Subepithelial Lesions Unknown status NCT02866045 Phase 3
2 Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754) Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride

Search NIH Clinical Center for Granular Cell Tumor

Cochrane evidence based reviews: granular cell tumor

Genetic Tests for Granular Cell Tumor

Anatomical Context for Granular Cell Tumor

MalaCards organs/tissues related to Granular Cell Tumor:

40
Breast, Tongue, Skin, Pituitary, Colon, Heart, Lung

Publications for Granular Cell Tumor

Articles related to Granular Cell Tumor:

(show top 50) (show all 1547)
# Title Authors PMID Year
1
Immunohistochemical expression of Galectin-3 and HBME-1 in granular cell tumors: a new finding. 61 54
18581283 2008
2
Granular cell tumor of the urethra. 61 54
17511737 2007
3
HMB-45 and Melan-A are useful in the differential diagnosis between granular cell tumor and malignant melanoma. 61 54
17284958 2007
4
A rare case of multiple congenital epulis. 54 61
15590438 2004
5
Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation. 61 54
15214825 2004
6
Recurrence and rapid metastasis formation of a granular cell tumor of the vulva. 54 61
12551796 2003
7
Expression of inhibin-alpha by granular cell tumors of the gallbladder and extrahepatic bile ducts. 54 61
11688581 2001
8
Granular cell tumor of the urinary bladder. 61 54
11168695 2001
9
Malignant granular cell tumor metastatic to the orbit. 61 54
10711894 2000
10
Granular cell tumor of the rectum: a case report and review of the literature. 54 61
10955603 2000
11
Histiocytic reaction in pelvic peritoneum associated with oxidized regenerated cellulose. 61 54
7817938 1995
12
[Granular cell tumor of the gingiva in the newborn. Report of a case in Martinique]. 54 61
7857416 1994
13
Coincident occurrence of granular cell tumor of the stomach with an early gastric carcinoma. 61 54
1547986 1992
14
Congenital granular cell tumor with systemic involvement. Immunohistochemical and ultrastructural study. 54 61
1929790 1991
15
Granular Cell Tumor Breast Masquerading as a Malignancy Cytologically: a Rare Case Presenting a Diagnostic Dilemma. 61
32523283 2020
16
Atypical granular cell tumor developing within a tattoo. 61
32490122 2020
17
Adult rhabdomyoma presenting as thyroid nodule on fine-needle aspiration in patient with Birt-Hogg-Dubé syndrome: Case report and literature review. 61
32187885 2020
18
Underwater endoscopic mucosal resection for esophageal granular cell tumor sized more than 1 cm. 61
32512623 2020
19
"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses. 61
32470708 2020
20
Granular Cell Tumor of the Pituitary Presenting with Major Intraventricular Hemorrhage. 61
32407921 2020
21
Smooth Auricular Cutaneous Granular Cell Tumor Mimics Epidermoid Cyst. 61
31671932 2020
22
Giant Granular Cell Tumor of the Cervical Spinal Cord Resected via Anterior Corpectomy with Reconstruction: Technical Note and Review of Literature. 61
32283320 2020
23
Granular Cell Tumor of the Perianal Region. 61
30820800 2020
24
Rare Treatment for a Rare Tumor: Cryoablation of a Granular Cell Tumor. 61
32399464 2020
25
Granular cell tumor a study of 42 cases and systemic review of the literature. 61
32089415 2020
26
Benign and Malignant Granular Cell Tumor of the Hypopharynx: Two Faces of a Rare Entity. 61
32240515 2020
27
Granular cell tumor of the breast: correlations between imaging and pathology findings. 61
32336825 2020
28
Congenital Granular Cell Epulis: Classic Presentation and Its Differential Diagnosis. 61
30888637 2020
29
Non-Neural (S-100 Negative) Bronchial Granular Cell Tumor Causing Acute Respiratory Failure. 61
31286806 2020
30
Prostate Benign Diseases. 61
32015291 2020
31
Sellar surprises: a single-centre experience of unusual sellar masses. 61
31910151 2020
32
[A case of gastric gastrointestinal stromal tumor complicated with granular cell tumor of abdominal wall]. 61
32074801 2020
33
Foreign Body (Solder) and Reaction to the Foreign Body Presenting As a Cutaneous Tender Tumor: Case Report and a New Acronym to Aid in Recalling the Differential Diagnosis of Painful Skin Lesions. 61
32190505 2020
34
Tumors of the Neurohypophysis: One Unit's Experience and Literature Review. 61
31734425 2020
35
Granular Cell Tumor of the Colon: An Exceptionally Rare Finding. 61
32043333 2020
36
A case of a gastric granular cell tumor preoperatively diagnosed and successfully treated by single-incision laparoscopic surgery. 61
32107653 2020
37
Abrikossoff's tumor of the tongue: Report of three cases and review of the literature. 61
32189915 2020
38
Intraneural granular cell tumor: Histologic spectrum and histogenetic implication. 61
31386226 2020
39
A Rare Perineurioma/Granular Cell Tumor Hybrid Peripheral Nerve Sheath Tumor. 61
31977319 2020
40
S-100-Negative malignant pulmonary granular cell tumor: A case report. 61
32015959 2020
41
A newborn with an oral mass: Non-neural granular cell tumor. 61
31793495 2020
42
Granular Cell Tumor of Thyroid: Challenging Pitfalls and Mimickers in Diagnosis. 61
32166057 2020
43
Clinical features and endoscopic findings of granular cell tumor of the sellar region: A case report and review of the literature. 61
32494380 2020
44
Granular Cell Tumor: A Rare Breast Lesion. 61
31928605 2020
45
A Rare Granular Cell Tumor with a Center Ulcer of the Rectum. 61
32395357 2020
46
Surgical resection of granular cell tumor of the sellar region: three indications. 61
31620953 2019
47
Granular cell tumor of the breast: a multidisciplinary challenge. 61
31710955 2019
48
Granular cell tumor of the trunk of the facial nerve: A case report: Erratum. 61
31702685 2019
49
Cytological Features of Cutaneous Granular Cell Tumor: A Brief Report. 61
31741584 2019
50
A Granular Cell Tumor Appearing at a Vaccination Site, a Possible Reaction to Trauma? 61
30371513 2019

Variations for Granular Cell Tumor

Expression for Granular Cell Tumor

Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for Granular Cell Tumor

Pathways related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.7 UCHL1 SYP S100B NKX2-1 MBP GFAP
2 11.51 VIM MBP GFAP
3
Show member pathways
11.37 VIM GFAP DES
4 11.15 VIM SYP S100B GFAP

GO Terms for Granular Cell Tumor

Cellular components related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.13 VIM GFAP DES
2 neuronal cell body GO:0043025 9.02 UCHL1 S100B MBP INHA ENO2

Biological processes related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 9.32 SYP S100B
2 astrocyte development GO:0014002 9.26 VIM GFAP
3 Bergmann glial cell differentiation GO:0060020 9.16 VIM GFAP
4 intermediate filament-based process GO:0045103 8.96 VIM GFAP
5 intermediate filament organization GO:0045109 8.8 VIM GFAP DES

Molecular functions related to Granular Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 VIM SYP S100B S100A1 GFAP DES
2 S100 protein binding GO:0044548 8.96 S100B S100A1
3 structural constituent of cytoskeleton GO:0005200 8.8 VIM GFAP DES

Sources for Granular Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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