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MCID: GRN017
MIFTS: 43

Granulocytopenia

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Granulocytopenia

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MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia 53
Agranulocytosis 73

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 73 C0001824
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Summaries for Granulocytopenia

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MalaCards based summary : Granulocytopenia, also known as agranulocytosis, is related to cohen syndrome and granulocytopenia with immunoglobulin abnormality. An important gene associated with Granulocytopenia is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Pertussis. The drugs Capecitabine and Tazobactam have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and myeloid, and related phenotype is immune system.

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Related Diseases for Granulocytopenia

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Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 cohen syndrome 30.4 ITGAM SELL
2 granulocytopenia with immunoglobulin abnormality 11.9
3 acute leukemia 11.3
4 periodontosis 10.4 ITGAM SELL
5 shwartzman phenomenon 10.4 ITGAM SELL
6 leukocyte adhesion deficiency, type i 10.4 ITGAM SELL
7 chronic venous insufficiency 10.4 ITGAM SELL
8 bronchopulmonary dysplasia 10.3 ITGAM SELL
9 boutonneuse fever 10.3 CP SELL
10 trichosporonosis 10.2 CSF3 TNF
11 penicilliosis 10.2 ITGAM TNF
12 leukemia 10.2
13 retinitis pigmentosa 60 10.1 SELL TNF
14 thrombocytopenia 10.1
15 arthus reaction 10.1 SELL TNF
16 pleurisy 10.0 SELL TNF
17 leukocyte disease 10.0 CSF3 TNF
18 chronic pulmonary heart disease 10.0 CP TNF
19 leukostasis 10.0
20 eales disease 10.0 CP TNF
21 protein-energy malnutrition 9.9 CP TNF
22 peritonitis 9.9 ITGAM TNF
23 arthritis 9.9
24 bacterial vaginosis 9.8 LAP3 TNF
25 monocytic leukemia 9.8 ITGAM TNF
26 hepatitis 9.8
27 lymphoma 9.8
28 immune system disease 9.8 CSF3 TNF
29 pneumoconiosis 9.8 CP TNF
30 leukemia, acute lymphoblastic 9.7
31 aspergillosis 9.7
32 hemolytic anemia 9.7
33 endocarditis 9.7
34 lymphoblastic leukemia 9.7
35 graves' disease 9.7
36 thymoma 9.7
37 lymphopenia 9.7
38 periodontitis 9.7
39 vasculitis 9.7
40 lupus erythematosus 9.7
41 germ cells tumors 9.7
42 kawasaki disease 9.6 SELL TNF
43 pre-eclampsia 9.6 ITGAM SELL TNF
44 biliary cirrhosis, primary, 1 9.6
45 breast cancer 9.6
46 systemic lupus erythematosus 9.6
47 rheumatoid arthritis 9.6
48 schizophrenia 9.6
49 ataxia-telangiectasia 9.6
50 cystic fibrosis 9.6

Graphical network of the top 20 diseases related to Granulocytopenia:



Diseases related to Granulocytopenia
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Symptoms & Phenotypes for Granulocytopenia

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MGI Mouse Phenotypes related to Granulocytopenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CP CSF3 ITGAM LAP3 SELL TNF
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Drugs & Therapeutics for Granulocytopenia

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Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 665)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
2
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
3
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 174722-31-7 10201696
4
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1 95058-81-4 60750
5
Cilastatin Approved, Investigational Phase 4,Not Applicable 82009-34-5 5280454 6435415
6
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
7
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
8
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
9
Menthol Approved Phase 4,Phase 2,Phase 1,Not Applicable 2216-51-5 16666
10
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
11
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
12
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 85721-33-1 2764
13
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
14
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7 64778 441130
15
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
16
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
17
Iron Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7439-89-6 23925
18
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
19
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 2 73590-58-6 4594
20
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
21
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
22
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
23
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
24
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
25
Imipenem Approved Phase 4,Not Applicable 74431-23-5, 64221-86-9 104838
26
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
27
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
28
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
29
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
30
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
31
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
32
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
33
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
34
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 441141 14969
35
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84625-61-6 55283
36
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
37
Docetaxel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 114977-28-5 148124
38
Ceftazidime Approved Phase 4,Phase 3,Phase 2 78439-06-2, 72558-82-8 5481173
39
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
40
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
41
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
42
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
43
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56420-45-2 41867
44
Valganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 175865-60-8 64147
45
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
46
Zinc Approved, Investigational Phase 4,Phase 3 7440-66-6 23994
47
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
48
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
49
Furosemide Approved, Vet_approved Phase 4,Phase 1 54-31-9 3440
50
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 21679-14-1, 75607-67-9 30751

Interventional clinical trials:

(show top 50) (show all 1358)
# Name Status NCT ID Phase Drugs
1 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
2 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
5 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
6 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Unknown status NCT02621905 Phase 4 Sporanox;Lozanoc
7 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Unknown status NCT02967341 Phase 4
8 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
9 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
10 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
11 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
12 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
13 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
14 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
15 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
16 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
17 REaCT Integrated Consent Model to Compare Two Standard of Care Regimens Completed NCT02173262 Phase 4 G-CSF;Ciprofloxacin
18 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
19 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
20 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
21 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
22 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy Completed NCT02805153 Phase 4 PEG-rhG-CSF;rhG-CSF
23 Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy Completed NCT00115206 Phase 4 Neulasta® (pegfilgrastim)
24 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
25 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
26 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
27 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
28 Antifungal Use in Oncohematological Neutropenic Patients Completed NCT00386802 Phase 4 Antifungal drug. VORICONAZOL. (VFEND®)
29 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
30 Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer Completed NCT00883675 Phase 4 Docetaxel-Carboplatin
31 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
32 A Study Comparing the Efficacy of Intravenous Followed by Oral Itraconazole With Intravenous Caspofungin For Empiric Antifungal Therapy in Neutropenic Participants With Hematological Malignancy Completed NCT02895529 Phase 4 Itraconazole;Caspofungin
33 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
34 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4 CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
35 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4 PEG-rhG-CSF
36 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
37 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
38 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
39 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
40 Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT Completed NCT01232504 Phase 4 rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
41 The Efficacy and Safety Study of Fuganlin Oral Liquid in Children With Influenza (Acute Upper Respiratory Infection) Completed NCT02622659 Phase 4 Fuganlin Oral Liquid;Xiaoer Jiebiao Oral Liquid
42 Oral Zinc Therapy for the Prevention of Mucositis Completed NCT00449592 Phase 4 Zinc;Placebo
43 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
44 Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours Completed NCT00220168 Phase 4 Irinotecan, Capecitabine
45 VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel Completed NCT01684813 Phase 4 Prasugrel.;Clopidogrel
46 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
47 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]
48 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4 Peginterferon alfa-2a;Peginterferon alfa-2a;Ribavirin
49 Enteric-coated Mycophenolate Sodium (EC-MPS) and Mycophenolate Mofetil (MMF) in Renal Transplant Patients With Gastrointestinal (GI) Intolerance Completed NCT00400400 Phase 4 Enteric-coated mycophenolate sodium (EC-MPS);Mycophenolate mofetil;Placebo to mycophenolate sodium;Placebo to mycophenolate mofetil
50 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]

Search NIH Clinical Center for Granulocytopenia

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Genetic Tests for Granulocytopenia

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Anatomical Context for Granulocytopenia

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MalaCards organs/tissues related to Granulocytopenia:

41
Breast, Lung, Myeloid, Bone, T Cells, Prostate, Bone Marrow
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Publications for Granulocytopenia

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Articles related to Granulocytopenia:

(show top 50) (show all 334)
# Title Authors Year
1
50 Years Ago in The Journal of Pediatrics: Familial Granulocytopenia and Associated Immunoglobulin Abnormality: Report of 3 Cases in Young Brothers. ( 29478506 )
2018
2
Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring. ( 28984748 )
2018
3
Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population. ( 28161127 )
2017
4
Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice. ( 28101584 )
2017
5
Atrial natriuretic peptide protects against cisplatin-induced granulocytopenia. ( 27286997 )
2016
6
Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population. ( 26876947 )
2016
7
Empiric Antimicrobial Regimens for Fever When Profound (<100/I1L) Granulocytopenia Persists. ( 25225417 )
2014
8
Risk of repeated febrile episodes during chemotherapy-induced granulocytopenia in children with cancer: a prospective single center study. ( 22759760 )
2012
9
Nafcillin-induced bullous skin eruption with granulocytopenia in a patient with end-stage renal disease. ( 22293804 )
2012
10
A rare case of Interferon-alpha-Induced Hyperthyroidism in patients with a chronic hepatitis C with granulocytopenia and transaminasemia treated successfully with radioiodine. ( 22635082 )
2012
11
Does switching to another antipsychotic in patients with clozapine-associated granulocytopenia solve the problem? Case series of 18 patients. ( 21346615 )
2011
12
Morning granulocytopenia in two patients with connective-tissue disease treated with oral corticosteroids. ( 22700349 )
2011
13
Add-on filgrastim during clozapine rechallenge in patients with a history of clozapine-related granulocytopenia/agranulocytosis. ( 19188296 )
2009
14
Propylthiouracil induced anti-neutrophil cytoplasmic antibody-associated vasculitis with bone marrow plasmacytosis and granulocytopenia. ( 19493451 )
2009
15
Granulocytopenia associated with thymoma in a domestic shorthaired cat. ( 18593858 )
2008
16
Puerperal Clostridium perfringens sepsis in a patient with granulocytopenia. ( 17675887 )
2008
17
Fatal toxic epidermal necrolysis and severe granulocytopenia following therapy with cefuroxime. ( 18812062 )
2008
18
Prevention of clozapine-induced granulocytopenia/agranulocytosis with granulocyte-colony stimulating factor (G-CSF) in an intellectually disabled patient with schizophrenia. ( 17181606 )
2007
19
Dipyrone-induced granulocytopenia: a case for awareness. ( 16503727 )
2006
20
Inflammatory pseudotumor of the liver in a patient with congenital granulocytopenia and HCV infection. ( 14652149 )
2003
21
Ciprofloxacin prophylaxis in patients with acute leukemia and granulocytopenia in an area with a high prevalence of ciprofloxacin-resistant Escherichia coli. ( 12518366 )
2003
22
Granulocytopenia associated with neuroleptic therapy in a patient with benign familial leukopenia. ( 24930415 )
2003
23
Penicillin-resistant Aerococcus viridans bacteremia associated with granulocytopenia. ( 11850599 )
2002
24
Anesthetic management of the patient with systemic lupus erythematosus and severe granulocytopenia. ( 14566552 )
2001
25
Agranulocytosis and granulocytopenia associated with quetiapine. ( 11722307 )
2001
26
Granulocytopenia with clozapine and quetiapine. ( 11282709 )
2001
27
Morning granulocytopenia in a case of Graves' disease. ( 11456265 )
2001
28
Fever and granulocytopenia in children with acute lymphoblastic leukemia under induction therapy. ( 11376385 )
2001
29
A 4-month-old infant showing anemia, granulocytopenia and thrombocytopenia probably due to autoreactive IgG. ( 11208010 )
2001
30
Reversible granulocytopenia in association with riluzole therapy. ( 10917377 )
2000
31
Acute bacterial endocarditis during granulocytopenia in an allogenic marrow transplant recipient. ( 11184775 )
2000
32
A second trial of clozapine in a case of granulocytopenia. ( 12404322 )
2000
33
Pathogenesis of granulocytopenia and bone marrow atrophy during classical swine fever involves apoptosis and necrosis of uninfected cells. ( 10873748 )
2000
34
Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. ( 10937789 )
2000
35
Olanzapine prolongation of granulocytopenia after clozapine discontinuation. ( 11106146 )
2000
36
Olanzapine treatment after clozapine-induced granulocytopenia in 3 patients. ( 10084639 )
1999
37
Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. ( 10423465 )
1999
38
Granulocytopenia due to nifuroxazide followed by a G-CSF-induced leukemoid reaction. ( 10573328 )
1999
39
Ceftriaxone/Amikacin vs Ceftazidime/Amikacin as Empirical Therapy for Fever in Patients with Haematological Malignancy and Severe Granulocytopenia: Clinical and Economic Outcomes. ( 18370498 )
1998
40
Clozapine metabolism rate as a possible index of drug-induced granulocytopenia. ( 9676893 )
1998
41
Pilot study of daily ifosfamide 1 g/m2 until grade III granulocytopenia as second-line chemotherapy for anthracycline-pretreated advanced soft tissue sarcoma. ( 10080676 )
1998
42
Increased neutrophil adhesive capability in Cohen syndrome, an autosomal recessive disorder associated with granulocytopenia. ( 9825573 )
1998
43
N-desmethylclozapine, an insensitive marker of clozapine-induced agranulocytosis and granulocytopenia. ( 9399615 )
1997
44
G-CSF-induced decrease of the anti-granulocyte autoantibody levels in a patient with autoimmune granulocytopenia. ( 9322685 )
1997
45
Usefulness of granulocyte count measurement four hours after injection of granulocyte colony-stimulating factor for detecting recovery from antithyroid drug-induced granulocytopenia. ( 9292945 )
1997
46
[Resolution of a disseminated infection by Fusarium solani in a patient with acute promyelocytic leukemia and granulocytopenia secondary to chemotherapy by the combined use of G-CSF and liposomal amphotericin B]. ( 9289532 )
1997
47
Severe granulocytopenia secondary to chlorpromazine despite concurrent lithium treatment: a case report. ( 9385781 )
1997
48
Successful treatment of a patient with Graves' disease on hemodialysis complicated by antithyroid drug-induced granulocytopenia and angina pectoris. ( 9292952 )
1997
49
Prolongation of clozapine-induced granulocytopenia associated with olanzapine. ( 9408818 )
1997
50
Cyanamide-induced granulocytopenia. ( 9313109 )
1997
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Variations for Granulocytopenia

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Expression for Granulocytopenia

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Search GEO for disease gene expression data for Granulocytopenia.
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Pathways for Granulocytopenia

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Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Innate Lymphoid Cell Differentiation Pathways 65
11.41 ITGAM TNF
2
Pertussis 37
11.38 ITGAM TNF
3
Hematopoietic cell lineage 37
11.32 CSF3 ITGAM TNF
4
Lung fibrosis 1
11.28 CSF3 TNF
5
Legionellosis 37
11.2 ITGAM TNF
6
Interleukin-10 signaling 66
11.12 CSF3 TNF
7
Malaria 37
11.09 CSF3 TNF
8
amb2 Integrin signaling 1
11.05 ITGAM TNF
9
MSP-RON Signaling 64
11 ITGAM TNF
10
Dendritic Cells Developmental Lineage Pathway 65
11 ITGAM SELL TNF
11
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.99 CSF3 ITGAM SELL TNF
12
Cytokines and Inflammatory Response 1
10.73 CSF3 TNF
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GO Terms for Granulocytopenia

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Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CP CPQ CSF3 ITGAM TNF
2 external side of plasma membrane GO:0009897 8.8 ITGAM SELL TNF

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.33 CSF3 ITGAM TNF
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.26 CSF3 TNF
3 leukocyte migration GO:0050900 9.13 ITGAM SELL TNF
4 leukocyte tethering or rolling GO:0050901 8.62 SELL TNF
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Sources for Granulocytopenia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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