Granulocytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GRN017 MIFTS: 51	Granulocytopenia Categories: Blood diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Granulocytopenia

MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia ⁵⁴

Agranulocytosis ⁷⁴

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Agranulocytosis

External Ids:

ICD10 ³⁴ D70

UMLS ⁷⁴ C0001824

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Summaries for Granulocytopenia

MalaCards based summary : Granulocytopenia, also known as agranulocytosis, is related to acute leukemia and cohen syndrome. An important gene associated with Granulocytopenia is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Vincristine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and myeloid, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷⁷ Granulocytes are a category of white blood cells characterized by the presence of granules in their... more...

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Related Diseases for Granulocytopenia

Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)

#	Related Disease	Score	Top Affiliating Genes
1	acute leukemia	32.2	CSF3 IL3 MPO
2	cohen syndrome	30.5	ITGAM SELL
3	neutropenia	30.4	CSF2 CSF3 IL3
4	felty syndrome	30.4	CSF2 CSF3 IL3
5	leukostasis	30.2	MPO SELL
6	shwartzman phenomenon	30.1	ITGAM TNF
7	vasculitis	29.9	MPO SELL TNF
8	stomatitis	29.8	CSF2 CSF3 TNF
9	bacterial infectious disease	29.8	CSF2 CSF3 ITGAM SELL TNF
10	chronic granulomatous disease	29.6	CSF2 CSF3 MPO
11	aplastic anemia	29.5	CSF2 CSF3 IL3 TNF
12	acute promyelocytic leukemia	28.8	CSF3 IL3 ITGAM ITGB2 MPO
13	immunodeficiency 59 and hypoglycemia	12.0
14	leukemia	10.4
15	thrombocytopenia	10.3
16	boutonneuse fever	10.3	CP SELL
17	retinitis pigmentosa 60	10.3	SELL TNF
18	penicilliosis	10.3	ITGAM TNF
19	engraftment syndrome	10.3	CSF2 CSF3
20	chronic pulmonary heart disease	10.2	CP TNF
21	1,4-phenylenediamine allergic contact dermatitis	10.2	NAT2 TNF
22	autoimmune inner ear disease	10.2	MPO TNF
23	chronic monocytic leukemia	10.2	ITGAM MPO
24	arthus reaction	10.2	SELL TNF
25	burns	10.2	CSF2 TNF
26	seborrheic infantile dermatitis	10.2	CSF2 IL3
27	microscopic polyangiitis	10.2	MPO TNF
28	stachybotrys chartarum	10.1	IL3 TNF
29	meconium aspiration syndrome	10.1	CSF2 TNF
30	trichosporonosis	10.1	CSF2 CSF3 TNF
31	marburg hemorrhagic fever	10.1	NQO2 TNF
32	deficiency anemia	10.1	CP CSF3 IL3
33	behcet syndrome	10.1	CP SELL TNF
34	monocytic leukemia	10.1	CSF2 ITGAM TNF
35	arthritis	10.1
36	cyclic neutropenia	10.1	CSF2 CSF3 IL3
37	anemia of prematurity	10.1	CSF2 CSF3 IL3
38	pleurisy	10.1	MPO SELL TNF
39	pancytopenia	10.1	CSF2 CSF3 IL3
40	peritonitis	10.1	ITGAM MPO TNF
41	toxic oil syndrome	10.1	CP NAT2
42	severe congenital neutropenia	10.0	CSF2 CSF3 IL3
43	proteasome-associated autoinflammatory syndrome 1	10.0	MPO SELL TNF
44	cytomegalovirus retinitis	10.0	CSF2 TNF
45	pneumonia	10.0	CSF3 MPO TNF
46	lymphoma	10.0
47	sarcoidosis 1	10.0	CSF2 IL3 TNF
48	scleritis	10.0	ITGB2 TNF
49	ileitis	10.0	CSF2 MPO TNF
50	essential thrombocythemia	9.9	IL3 ITGAM MPO

Graphical network of the top 20 diseases related to Granulocytopenia:

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Symptoms & Phenotypes for Granulocytopenia

MGI Mouse Phenotypes related to Granulocytopenia:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.61	CP CSF2 CSF3 ITGAM ITGB2 MPO
2	immune system	MP:0005387	9.32	CP CSF2 CSF3 ITGAM ITGB2 LAP3

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Drugs & Therapeutics for Granulocytopenia

Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 761)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Vincristine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

2068-78-2, 57-22-7

5978

Methotrexate

Approved

Phase 4,Phase 2,Phase 3,Phase 1

1959-05-2, 59-05-2

126941

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

53-03-2

5865

Epirubicin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

56420-45-2

41867

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

50-18-0, 6055-19-2

2907

Oxaliplatin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

61825-94-3

43805 6857599 5310940 9887054

Cisplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

15663-27-1

2767 441203 84093

Etoposide

Approved

Phase 4,Phase 3,Phase 2,Phase 1

33419-42-0

36462

Cytarabine

Approved, Experimental, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

147-94-4, 65-46-3

6253

Doxorubicin

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1

23214-92-8

31703

Gemcitabine

Approved

Phase 4,Phase 2,Phase 3,Phase 1

95058-81-4

60750

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

50-02-2

5743

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

124-94-7

31307

Lenograstim

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

135968-09-1

Ceftazidime

Approved

Phase 4,Phase 3,Phase 2

72558-82-8, 78439-06-2

5481173

Tazobactam

Approved

Phase 4,Phase 2,Not Applicable

89786-04-9

123630

Vancomycin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

1404-90-6

14969 441141

Meropenem

Approved, Investigational

Phase 4,Phase 2

119478-56-7, 96036-03-2

441130 64778

Piperacillin

Approved

Phase 4,Phase 2,Not Applicable

66258-76-2

43672

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

22916-47-8

4189

Micafungin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

235114-32-6

477468 3081921

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

85721-33-1

2764

Sulfamethoxazole

Approved

Phase 4,Phase 2

723-46-6

5329

Trimethoprim

Approved, Vet_approved

Phase 4,Phase 2

738-70-5

5578

Iron

Approved, Experimental

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

7439-89-6, 15438-31-0

27284 23925

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2

73590-58-6

4594

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Sargramostim

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

123774-72-1, 83869-56-1

Docetaxel

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

114977-28-5

148124

leucovorin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

58-05-9

143 6006

Voriconazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

137234-62-9

71616

Carboplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

41575-94-4

10339178 38904 498142

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

302-25-0

Prednisolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

50-24-8

5755

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 2,Phase 3,Phase 1

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

83-43-2

6741

Fluorouracil

Approved

Phase 4,Phase 3,Phase 2,Phase 1

51-21-8

3385

Paclitaxel

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

33069-62-4

36314

Idarubicin

Approved

Phase 4,Phase 3,Phase 2,Phase 1

58957-92-9

42890

Irinotecan

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

100286-90-6, 97682-44-5

60838

Capecitabine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

154361-50-9

60953

Sirolimus

Approved, Investigational

Phase 4,Phase 2,Phase 1

53123-88-9

46835353 5284616 6436030

Everolimus

Approved

Phase 4,Phase 2,Phase 1

159351-69-6

70789204 6442177

Ganciclovir

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

82410-32-0

3454

Valganciclovir

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

175865-60-8

64147

rituximab

Approved

Phase 4,Phase 2,Phase 3,Phase 1

174722-31-7

10201696

Vinblastine

Approved

Phase 4,Phase 2,Phase 1

865-21-4

241903 13342

Pemetrexed

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

150399-23-8, 137281-23-3

60843 446556

Povidone

Approved

Phase 4,Phase 2,Phase 1

9003-39-8

Interventional clinical trials:

(show top 50) (show all 1530)

#	Name	Status	NCT ID	Phase	Drugs
1	PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia	Unknown status	NCT02996617	Phase 4	rhG-CSF regimen;Pegylated rhG-CSF regimen
2	Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy	Unknown status	NCT01571518	Phase 4	late leukostim;early leukostim
3	Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia	Unknown status	NCT02463747	Phase 4	Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4	Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer	Unknown status	NCT00030758	Phase 4
5	The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy	Unknown status	NCT02905916	Phase 4	PEG-rhG-CSF
6	Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation	Unknown status	NCT01135589	Phase 4	Micafungin
7	Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients	Unknown status	NCT02967341	Phase 4
8	Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients	Unknown status	NCT02605213	Phase 4	Vancomycin;Placebo
9	Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda	Unknown status	NCT00674921	Phase 4	cotrimoxazole;Placebo
10	Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC	Unknown status	NCT01795794	Phase 4	omeprazole
11	THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS	Unknown status	NCT02241876	Phase 4	N-acetylcysteine
12	Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia	Completed	NCT01581333	Phase 4	Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
13	Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia	Completed	NCT02213783	Phase 4	Imipenem;Imipenem
14	A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen	Completed	NCT01107756	Phase 4	LENOGRASTIM (GRANOGYTE 34)
15	PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia	Completed	NCT02805205	Phase 4	PEG-rhG-CSF
16	Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer	Completed	NCT01649635	Phase 4	CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
17	REaCT Integrated Consent Model to Compare Two Standard of Care Regimens	Completed	NCT02173262	Phase 4	G-CSF;Ciprofloxacin
18	Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome	Completed	NCT01200355	Phase 4	micafungin;posaconazole
19	Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients	Completed	NCT01401010	Phase 4	Doripenem;doripenem
20	A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer	Completed	NCT00277160	Phase 4	Neulasta (pegfilgrastim)
21	FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy	Completed	NCT00125723	Phase 4
22	PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy	Completed	NCT02805153	Phase 4	PEG-rhG-CSF;rhG-CSF
23	Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy	Completed	NCT00115206	Phase 4	Neulasta® (pegfilgrastim)
24	Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients	Completed	NCT00454272	Phase 4	Teicoplanin;Vancomycin
25	Safety of Cotrimoxazole in HIV- and HAART-exposed Infants	Completed	NCT01086878	Phase 4	cotrimoxazole
26	The Tobramycin Study	Completed	NCT00257790	Phase 4	Tobramycin once a day
27	Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections	Completed	NCT00709358	Phase 4
28	Antifungal Use in Oncohematological Neutropenic Patients	Completed	NCT00386802	Phase 4	Antifungal drug. VORICONAZOL. (VFEND®)
29	Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg	Completed	NCT02621905	Phase 4	Sporanox;Lozanoc
30	An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL)	Completed	NCT02782845	Phase 4	Chemotherapy;Immunochemotherapy;Pegfilgrastim
31	Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer	Completed	NCT00883675	Phase 4	Docetaxel-Carboplatin
32	Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients	Completed	NCT01114165	Phase 4
33	Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)	Completed	NCT00686543	Phase 4	Posaconazole
34	Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer	Completed	NCT02441894	Phase 4	CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
35	PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy	Completed	NCT02805166	Phase 4	PEG-rhG-CSF
36	PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy	Completed	NCT02805218	Phase 4	PEG-rhG-CSF
37	Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer	Completed	NCT02284529	Phase 4	Orectalip
38	Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma	Completed	NCT00969462	Phase 4	Doxorubicin
39	Multicenter Study of Pharmacokinetic-Guided Docetaxel in Breast Cancer Patients Receiving Docetaxel and Cyclophosphamide	Completed	NCT02502864	Phase 4	Standard of Care: Docetaxel;Standard of Care: Cyclophosphamide
40	Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection	Completed	NCT01198236	Phase 4	Itraconazole
41	Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly	Completed	NCT02151149	Phase 4	nab-paclitaxel;Carboplatin
42	Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT	Completed	NCT01232504	Phase 4	rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
43	The Efficacy and Safety Study of Fuganlin Oral Liquid in Children With Influenza (Acute Upper Respiratory Infection)	Completed	NCT02622659	Phase 4	Fuganlin Oral Liquid;Xiaoer Jiebiao Oral Liquid
44	Oral Zinc Therapy for the Prevention of Mucositis	Completed	NCT00449592	Phase 4	Zinc;Placebo
45	SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia	Completed	NCT00487448	Phase 4	Fludarabine;Cytarabine;G-CSF;Idarubicin
46	Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours	Completed	NCT00220168	Phase 4	Irinotecan, Capecitabine
47	Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A	Completed	NCT02328963	Phase 4	Everolimus;mycophenolic acid
48	VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel	Completed	NCT01684813	Phase 4	Prasugrel.;Clopidogrel
49	Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP)	Completed	NCT00907478	Phase 4
50	A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a)	Completed	NCT01585324	Phase 4	peginterferon alfa-2a [Pegasys];ribavirin [Copegus]

Search NIH Clinical Center for Granulocytopenia

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Genetic Tests for Granulocytopenia

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Anatomical Context for Granulocytopenia

MalaCards organs/tissues related to Granulocytopenia:

⁴²

Breast, Lung, Myeloid, Bone, Bone Marrow, Prostate, T Cells

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Publications for Granulocytopenia

Articles related to Granulocytopenia:

(show top 50) (show all 1830)

#	Title	Authors	Year
1	Clozapine-Associated Cytomegalovirus Colitis and Related Critical Illness in a Patient With Neither Neutropenia Nor Agranulocytosis. ( 30280578 )	Chu CW...Liang CS	2019
2	Treatment effectiveness of levamisole plus prednisolone on oral lichen planus patients with emphasis on levamisole-induced agranulocytosis or pancytopenia. ( 30922614 )	Lu SY...Lin CJ	2019
3	Pediatric drug safety signal detection of non-chemotherapy drug-induced neutropenia and agranulocytosis using electronic healthcare records. ( 31002530 )	Wei R...Wang XL	2019
4	Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study. ( 30648930 )	Gershinsky M...Gronich N	2019
5	Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. ( 30328081 )	Aslan N...Ozden O	2019
6	Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence. ( 30778952 )	Erg?n H...G?ner MD	2019
7	Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population. ( 30814476 )	He YY...Zhang B	2019
8	Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand. ( 30856469 )	Tunsirimas N...Ratta-Apha W	2019
9	The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies. ( 30857568 )	Li XH...Xiang YT	2019
10	Failure of rechallenge clozapine after agranulocytosis: A case report. ( 30878138 )	Rom?o B...Benyamina A	2019
11	Dabigratan-related acute agranulocytosis. ( 31013250 )	Al-Khaffaf A...Franchini M	2019
12	Associations of HLA genotypes with antithyroid drug-induced agranulocytosis: a systematic review and meta-analysis of pharmacogenomics studies. ( 31108563 )	Chen WT...Chi CC	2019
13	Metamizole (dipyrone)-induced agranulocytosis: Does the risk vary according to ethnicity? ( 30311250 )	Shah RR	2019
14	Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies. ( 30604305 )	Gadhave DG...Kokare CR	2019
15	Acute agranulocytosis when switching from risperidone to paliperidone. ( 30636434 )	Wakuda T...Yamasue H	2019
16	Monocytopenia in clozapine-induced agranulocytosis: insights into pathophysiology and treatment. ( 30661042 )	Patel R...Hoffman M	2019
17	Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report. ( 30594147 )	Shi R...Wang Q	2018
18	Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report. ( 30577288 )	Saida K...Ishikura K	2018
19	Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters. ( 29789870 )	Bielen L...Bo?ina N	2018
20	Agranulocytosis and Good Syndrome in Patient with Thymoma-The Role of Immunosuppressive Treatment after Thymectomy. ( 30166018 )	Markovic O...Marisavljevic D	2018
21	Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring. ( 28984748 )	Wici?ski M...W?clewicz MM	2018
22	50 Years Ago in The Journal of Pediatrics: Familial Granulocytopenia and Associated Immunoglobulin Abnormality: Report of 3 Cases in Young Brothers. ( 29478506 )	Heikamp E...Forbes L	2018
23	Granulocytopenia. ( 30193521 )	?erm?k J	2018
24	A case of antithyroid drug-induced agranulocytosis from a second antithyroid drugs (ATD) administration in a relapsed Graves' disease patient who was tolerant to the first ATD treatment. ( 30214745 )	Kim H...Ha J	2018
25	Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. ( 29552362 )	Garla V...Abdul Salim S	2018
26	Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. ( 30364514 )	Tozuka T...Gemma A	2018
27	Recurrent Levamisole-Induced Agranulocytosis Complicated by Bowel Ischemia in a Cocaine User. ( 29853712 )	Khan MS...Yoon Y	2018
28	Complete remission of agranulocytosis after splenectomy in a variant form of T-cell large granular lymphocyte leukemia. ( 29963929 )	Lozano C...Gris JC	2018
29	Agranulocytosis Associated with Waldenström Macroglobulinemia. ( 30114687 )	Vaxman I...Lahav M	2018
30	Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky. ( 30549484 )	Boazak M...Cotes RO	2018
31	Re-titration rates after clozapine-induced neutropenia or agranulocytosis: A case report and literature review. ( 29944418 )	Boazak M...Cotes RO	2018
32	Thiamazole-Induced Agranulocytosis Leading to Abscessus Pneumonia-Rare, But Challenging. ( 29203051 )	Lazovic B...Zugic V	2018
33	Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis. ( 30319405 )	Numata S...Hashimoto R	2018
34	Agranulocytosis associated with voriconazole-induced hypersensitivity syndrome. ( 29168223 )	Kaneko Y...Hashizume H	2018
35	Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus. ( 28762467 )	Wadelius M...EuDAC	2018
36	Decreased miR-17-92 cluster expression level in serum and granulocytes preceding onset of antithyroid drug-induced agranulocytosis. ( 29255972 )	Yang J...Wen G	2018
37	Safety of dipyrone (metamizole) in children-What's the risk of agranulocytosis? ( 29345086 )	Ziesenitz VC...van den Anker JN	2018
38	Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature. ( 29404875 )	Fasullo S...Maringhini G	2018
39	Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?" ( 29436141 )	de Leeuw TG...de Wildt SN	2018
40	Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases. ( 29545956 )	Lohani S...Donato A	2018
41	Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor. ( 29560017 )	Kubota Y...Toh Yoon EW	2018
42	A Case of Levamisole-Induced Agranulocytosis. ( 29607229 )	Kassim T...Gbadamosi-Akindele M	2018
43	Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept. ( 29633650 )	Jiang Q...Li W	2018
44	Transient immune-mediated agranulocytosis following Mycoplasma pneumoniae infection. ( 29669774 )	Barge L...Weber N	2018
45	Clozapine pharmacogenomics: a review of efficacy, pharmacokinetics, and agranulocytosis. ( 29985178 )	Li KJ...DeLisi LE	2018
46	Erratum to "Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor". ( 30034475 )	Kubota Y...Toh Yoon EW	2018
47	Zero Eosinophil Count as a Predictor of Clozapine-Associated Late-Onset Agranulocytosis: A Case Report. ( 30113930 )	Yang HN...Liang CS	2018
48	Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients. ( 30123266 )	Thao MP...Minh DD	2018
49	Agranulocytosis Induced by Vancomycin. Case Report and Literature Review. ( 30174327 )	di Fonzo H...Rueda D	2018
50	Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice. ( 28101584 )	Zenitani M...Kangawa K	2017

Sources

Genes for Granulocytopenia

Genes related to Granulocytopenia (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ITGAM	Integrin Subunit Alpha M	Protein Coding	22.31	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	8856254 1292337 7490516
2	SELL	Selectin L	Protein Coding	20.63	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	10945396 17567268 7490516 (more) 8856254
3	IL3	Interleukin 3	Protein Coding	18.31	Novoseek inferred ⁵⁶	7528487 10942973 7906401 (more) 8524426 8834013 7687857 7693069 7536476 7543179 9017166 9009076 10221368 8265854 7511003 10605203 14984824 18613811 8338776 7525542 7528854 9130684 7801148 7579485 10738502 12186123 7694163 7543178 7579383 16043267
4	CSF3	Colony Stimulating Factor 3	Protein Coding	18.24	Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15644577 9292945 18181220 (more) 7679571 15785251 7693069 7525366 10037073 11140884 8927660 7541156 11959056 9028308 7530522 15251798 9017166 10937789 1281122 1698422 7685193 11094146 9292952 7512460 7693988 7525542 7522393 7515127 7523362 7509672 10695110 9578815 7528854 10560960 7504534 7692832 9271776 7516556 1709218 1374635 11496310 11014957 10917583 9815746 9019189 7727054 7533691 7525175 7511003 9503276 8129380 7504155 7687052 1374636 14692133 16595571 11255275 9803142 8983890 17152498 16043267 12661801 12424538 9229817 8985818 8918674 7549901 7526087 7525662 8152201 7507240 7504975 7692002 1702678 20305597 16006735 10792393 10071282 9668543 7485091 7538658 8342541 1690024 20462096 18774664 18031129 12702898 8605273 7540528 7539786 8052932 7681134 1383662 1697455 11903469 7679557 1283811 1380205 1722234 7530591
5	CSF2	Colony Stimulating Factor 2	Protein Coding	17.7	Novoseek inferred ⁵⁶	8824661 1697455 1556524 (more) 8315450 7727054 7528487 8503246 7538825 8460920 18031129 1639744 7621631 8305835
6	MPO	Myeloperoxidase	Protein Coding	17.06	Novoseek inferred ⁵⁶	15538122 17602675 18489081 (more) 9038241 1346986 8385460 11147929
7	CP	Ceruloplasmin	Protein Coding	16.69	GeneCards inferred via : Publications (show sections)
8	CPQ	Carboxypeptidase Q	Protein Coding	16.69	GeneCards inferred via : Publications (show sections)
9	TNF	Tumor Necrosis Factor	Protein Coding	16.69	GeneCards inferred via : Publications (show sections)
10	NQO2	N-Ribosyldihydronicotinamide:Quinone Reductase 2	Protein Coding	15.25	Novoseek inferred ⁵⁶	14617031
11	ITGB2	Integrin Subunit Beta 2	Protein Coding	13.69	Novoseek inferred ⁵⁶	10945396 17567268
12	NAT2	N-Acetyltransferase 2	Protein Coding	12.51	Novoseek inferred ⁵⁶	10739170
13	HLA-S	Major Histocompatibility Complex, Class I, S (Pseudogene)	Pseudogene	6.69	GeneCards inferred via : Publications (show sections)
14	LAP3	Leucine Aminopeptidase 3	Protein Coding	6.69	GeneCards inferred via : Publications (show sections)

Sources

Variations for Granulocytopenia

Sources

Expression for Granulocytopenia

Search GEO for disease gene expression data for Granulocytopenia.

Sources

Pathways for Granulocytopenia

Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶⁵ Show member pathways p38 Signaling ⁶⁵ Tec Kinases Signaling ⁶⁵	13.25	CSF2 CSF3 IL3 ITGAM ITGB2 TNF
2	Cytokine Signaling in Immune system ⁶⁷ Show member pathways Signaling by Interleukins ⁶⁷	13.2	CSF2 CSF3 IL3 ITGAM ITGB2 TNF
3	NF-kappaB Signaling ⁴	12.41	IL3 ITGB2 MPO TNF
4	Immune response Role of DAP12 receptors in NK cells ²³ Show member pathways Immune response CD16 signaling in NK cells ²³ Natural killer cell mediated cytotoxicity ³⁸	12.37	CSF2 IL3 ITGB2 TNF
5	Toxoplasmosis ³⁸ Show member pathways Leishmaniasis ³⁸	12.09	ITGAM ITGB2 TNF
6	Transcriptional misregulation in cancer ³⁸	12.09	CSF2 IL3 ITGAM MPO
7	Cell surface interactions at the vascular wall ⁶⁷ Show member pathways Fibronectin matrix formation ⁶⁷ PECAM1 interactions ⁶⁷ Tie2 Signaling ⁶⁷	12.07	ITGAM ITGB2 SELL
8	Tuberculosis ³⁸	12.07	ITGAM ITGB2 TNF
9	Phagosome ³⁸	11.99	ITGAM ITGB2 MPO
10	Cell adhesion molecules (CAMs) ³⁸	11.97	ITGAM ITGB2 SELL
11	Interleukin-4 and 13 signaling ⁶⁷	11.84	ITGAM ITGB2 TNF
12	Microglia Activation During Neuroinflammation: Overview ⁶⁶ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁶	11.83	CSF2 ITGAM ITGB2 TNF
13	Rheumatoid arthritis ³⁸	11.72	CSF2 ITGB2 TNF
14	Amoebiasis ³⁸	11.65	CSF2 ITGAM ITGB2 TNF
15	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.63	CSF2 IL3 TNF
16	Pertussis ³⁸	11.62	ITGAM ITGB2 TNF
17	Lung fibrosis ¹	11.53	CSF2 CSF3 TNF
18	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11.49	CSF2 ITGAM SELL TNF
19	Legionellosis ³⁸	11.46	ITGAM ITGB2 TNF
20	Interleukin-10 signaling ⁶⁷	11.38	CSF2 CSF3 TNF
21	Malaria ³⁸	11.36	CSF3 ITGB2 TNF
22	Hematopoietic cell lineage ³⁸	11.34	CSF2 CSF3 IL3 ITGAM TNF
23	Hematopoietic Stem Cell Differentiation ¹	11.33	CSF2 CSF3 IL3
24	MSP-RON Signaling ⁶⁵	11.31	ITGAM ITGB2 TNF
25	amb2 Integrin signaling ¹	11.24	ITGAM ITGB2 MPO TNF
26	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.23	CSF2 CSF3 IL3 ITGAM MPO SELL
27	G-protein signaling_RhoB regulation pathway ²³	11.07	CSF2 CSF3 IL3 TNF
28	Cytokines and Inflammatory Response ¹	10.92	CSF2 CSF3 IL3 TNF
29	LDL Oxidation in Atherogenesis ⁶⁵	10.82	MPO TNF
30	G-protein signaling_Rap2B regulation pathway ²³	10.78	CSF2 CSF3 IL3 ITGAM ITGB2 TNF

Sources

GO Terms for Granulocytopenia

Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.91	CP CPQ CSF2 CSF3 IL3 MPO
2	extracellular exosome	GO:0070062	9.8	CP CPQ ITGAM ITGB2 LAP3 MPO
3	extracellular space	GO:0005615	9.56	CP CPQ CSF2 CSF3 IL3 ITGAM
4	external side of plasma membrane	GO:0009897	9.46	ITGAM ITGB2 SELL TNF
5	integrin complex	GO:0008305	9.4	ITGAM ITGB2
6	plasma membrane raft	GO:0044853	9.32	ITGAM ITGB2
7	integrin alphaM-beta2 complex	GO:0034688	8.62	ITGAM ITGB2

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.89	CSF2 CSF3 IL3 TNF
2	neutrophil degranulation	GO:0043312	9.88	ITGAM ITGB2 MPO SELL
3	regulation of signaling receptor activity	GO:0010469	9.86	CSF2 CSF3 IL3 TNF
4	cellular response to lipopolysaccharide	GO:0071222	9.74	CSF2 CSF3 TNF
5	leukocyte migration	GO:0050900	9.71	ITGAM ITGB2 SELL TNF
6	positive regulation of protein targeting to membrane	GO:0090314	9.58	ITGAM ITGB2
7	leukocyte tethering or rolling	GO:0050901	9.55	SELL TNF
8	toll-like receptor 4 signaling pathway	GO:0034142	9.54	ITGAM ITGB2
9	positive regulation of superoxide anion generation	GO:0032930	9.52	ITGAM ITGB2
10	negative regulation of growth of symbiont in host	GO:0044130	9.51	MPO TNF
11	amyloid-beta clearance	GO:0097242	9.49	ITGAM ITGB2
12	cell-cell adhesion via plasma-membrane adhesion molecules	GO:0098742	9.48	ITGAM ITGB2
13	positive regulation of podosome assembly	GO:0071803	9.46	CSF2 TNF
14	positive regulation of microglial cell activation	GO:1903980	9.43	ITGAM ITGB2
15	cellular extravasation	GO:0045123	9.37	ITGB2 TNF
16	negative regulation of dopamine metabolic process	GO:0045963	9.32	ITGAM ITGB2
17	positive regulation of neutrophil degranulation	GO:0043315	9.26	ITGAM ITGB2
18	positive regulation of prostaglandin-E synthase activity	GO:2000363	9.16	ITGAM ITGB2
19	microglial cell activation	GO:0001774	9.13	ITGAM ITGB2 TNF
20	cytokine-mediated signaling pathway	GO:0019221	9.1	CSF2 CSF3 IL3 ITGAM ITGB2 TNF

Molecular functions related to Granulocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.33	CSF2 CSF3 IL3
2	cytokine activity	GO:0005125	9.26	CSF2 CSF3 IL3 TNF
3	complement component C3b binding	GO:0001851	8.62	ITGAM ITGB2

Sources

Sources for Granulocytopenia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia