MCID: GRN017
MIFTS: 42

Granulocytopenia

Categories: Blood diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Granulocytopenia

MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia 19 75 75
Agranulocytosis 71 31

Classifications:



External Ids:

ICD10 31 D70
UMLS 71 C0001824

Summaries for Granulocytopenia

GARD: 19 A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

MalaCards based summary: Granulocytopenia, also known as agranulocytosis, is related to neutropenia, severe congenital, 3, autosomal recessive and cyclic neutropenia. An important gene associated with Granulocytopenia is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Lenograstim and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, neutrophil and bone, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: 75 Granulocytes are cells in the innate immune system characterized by the presence of specific granules in... more...

Related Diseases for Granulocytopenia

Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 580)
# Related Disease Score Top Affiliating Genes
1 neutropenia, severe congenital, 3, autosomal recessive 32.2 IL3 CSF3 CSF2
2 cyclic neutropenia 31.5 IL3 CSF3 CSF2
3 exanthem 30.3 MPO CSF3 CSF2
4 leukostasis 30.2 SELL MPO
5 felty syndrome 30.2 IL3 CSF3 CSF2
6 cellulitis 30.2 CSF3 CSF2
7 thrombocytosis 30.2 IL3 CSF3 CSF2
8 mucormycosis 30.1 CSF3 CSF2
9 acute leukemia 30.1 MPO IL3 CSF3 CSF2
10 cohen syndrome 30.1 SELL ITGAM
11 lymphoma, hodgkin, classic 30.1 IL3 CSF3 CSF2
12 allergic disease 30.0 SELL IL3 CSF2
13 hypersplenism 30.0 CSF3 CSF2
14 pancytopenia 29.9 MPO IL3 CSF3 CSF2
15 pneumonia 29.8 MPO ITGAM CSF3 CSF2
16 neutrophilic dermatosis, acute febrile 29.7 MPO CSF3
17 neutropenia 29.7 SELL MPO ITGAM IL3 CSF3 CSF2
18 hypereosinophilic syndrome 29.7 MPO IL3 CSF2
19 adult respiratory distress syndrome 29.7 SELL MPO ITGAM
20 aplastic anemia 29.6 MPO IL3 CSF3 CSF2
21 venous insufficiency 29.6 SELL ITGAM
22 mucositis 29.6 IL3 CSF3 CSF2
23 severe congenital neutropenia 29.5 MPO IL3 CSF3 CSF2
24 leukemia, chronic myeloid 29.5 MPO IL3 CSF3 CSF2
25 bacterial sepsis 29.5 ITGAM CSF3 CSF2
26 pyoderma 29.5 ITGB2 CSF3
27 gastroenteritis 29.5 IL3 CSF3 CSF2
28 meningitis 29.5 MPO CSF3 CSF2
29 paroxysmal nocturnal hemoglobinuria 29.4 IL3 CSF3 CSF2
30 chronic granulomatous disease 29.4 MPO CSF3 CSF2
31 neutrophilia, hereditary 29.4 MPO IL3 CSF3 CSF2
32 leukemia, acute myeloid 29.4 MPO ITGAM IL3 CSF3 CSF2
33 diarrhea 29.4 MPO IL3 CSF3
34 respiratory failure 29.4 MPO CSF3 CSF2
35 common variable immunodeficiency 29.3 SELL MPO ITGAM
36 thrombocytopenia 29.3 SELL ITGB2 ITGAM IL3 CSF3 CSF2
37 myelofibrosis 29.3 MPO ITGAM IL3 CSF3
38 lymphoma, non-hodgkin, familial 29.3 SELL ITGAM IL3 CSF3 CSF2
39 pyoderma gangrenosum 29.2 ITGB2 CSF3
40 connective tissue disease 29.2 MPO ITGAM CSF3 CSF2
41 polycythemia vera 29.2 MPO IL3 CSF3 CSF2
42 leukemia, acute lymphoblastic 29.2 SELL MPO ITGAM IL3 CSF3 CSF2
43 myeloid leukemia 29.1 MPO IL3 CSF3 CSF2
44 vasculitis 29.1 SELL MPO ITGB2 ITGAM
45 peripheral nervous system disease 29.1 MPO ITGAM CSF3 CSF2
46 leukocyte adhesion deficiency, type i 29.0 SELL ITGB2 ITGAM CSF3
47 leukemia, chronic lymphocytic 28.9 SELL ITGB2 CSF3 CSF2
48 rheumatoid arthritis 28.9 SELL MPO ITGB2 ITGAM CSF2
49 cystic fibrosis 28.8 NAT2 MPO ITGAM CSF3 CSF2
50 immune deficiency disease 28.8 SELL ITGB2 ITGAM CSF2

Graphical network of the top 20 diseases related to Granulocytopenia:



Diseases related to Granulocytopenia

Symptoms & Phenotypes for Granulocytopenia

MGI Mouse Phenotypes related to Granulocytopenia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 CSF2 HYOU1 IL3 ITGAM ITGB2 MPO
2 immune system MP:0005387 9.56 CSF2 CSF3 IL3 ITGAM ITGB2 MPO
3 hematopoietic system MP:0005397 9.23 CSF2 CSF3 IL3 ITGAM ITGB2 MPO

Drugs & Therapeutics for Granulocytopenia

Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 2 135968-09-1
2
Epirubicin Approved Phase 2 56420-45-2 41867
3
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
4
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
5
Altretamine Approved Phase 2 645-05-6 2123
6
Caspofungin Approved Phase 2 179463-17-3, 162808-62-0 2826718
7
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
8
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
9 Adjuvants, Immunologic Phase 2
10 Immunologic Factors Phase 2
11 Anti-Infective Agents Phase 2
12 Antifungal Agents Phase 2
13
Iodine Approved, Investigational 7553-56-2 807
14
Loncastuximab tesirine Approved, Investigational 1879918-31-6
15
Inotuzumab ozogamicin Approved, Investigational 635715-01-4
16
Brentuximab vedotin Approved, Investigational 914088-09-8
17
Trastuzumab Approved, Investigational 180288-69-1
18
Tisotumab vedotin Approved 1418731-10-8
19
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3 3680
20
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 3003 5743
21 Antithyroid Agents
22 Liver Extracts
23 Immunoglobulins, Intravenous
24
Ado-Trastuzumab Emtansine
25 Immunoglobulins
26 Immunoconjugates
27 Antibodies
28 Gemtuzumab
29 Immunotoxin HA22

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Phase IIb Study of Recombinant Human Serum Albumin/ Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Breast Cancer Patients Completed NCT03251768 Phase 2 rHSA-GCSF 2.4mg;GCSF
2 Efficacy and Safety Phase II Study of Recombinant Human Serum Albumin/Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Patients Completed NCT02465801 Phase 2 HSA-GCSF 1.2 mg;HSA-GCSF 1.5 mg;GCSF
3 An Open,Multicenter Clinic Trial of the Effectiveness,Safety and Pharmacokinetics in the Empiric Therapy of Patients With Persistent Fever and Agranulocytosis Using Local Caspofungin Completed NCT03857399 Phase 2 Caspofungin
4 Efficacy and Safety Phase Ib Study of Recombinant Human Serum Albumin/ Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Patients Completed NCT03246009 Phase 1 rHSA/GCSF
5 Genetic Study of Antithyroid Drugs Associated Agranulocytosis Unknown status NCT01977963
6 Effectiveness of Classical Potassium Iodide Therapy for the Treatment of Untreated Patients With Graves' Hyperthyroidism, Avoiding Thionamide Drugs With Serious Side Effects of Agranulocytosis, Liver Injury, Vasculitis, Embryopathy or Frequent Side Effects of Skin Eruption Completed NCT04686006 Potassium Iodide
7 Etiology of Blood Dyscrasias: Analysis of the International Agranulocytosis and Aplastic Anemia Study Data Completed NCT00005307
8 Evaluation of Reporting of Antibody-Drug Conjugate Associated Sepsis-related Toxicities Using International Pharmacovigilance Database Completed NCT05349383 Antibody-Drug Conjugate;Antineoplastic and immunomodulating agents other than Antibody-Drug Conjugate
9 Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent Completed NCT00059423
10 Drug Etiology of Aplastic Anemia and Related Dyscrasias Completed NCT00005302

Search NIH Clinical Center for Granulocytopenia

Genetic Tests for Granulocytopenia

Anatomical Context for Granulocytopenia

Organs/tissues related to Granulocytopenia:

MalaCards : Bone Marrow, Neutrophil, Bone, Breast, Liver, Lung, Skin

Publications for Granulocytopenia

Articles related to Granulocytopenia:

(show top 50) (show all 6721)
# Title Authors PMID Year
1
Agranulocytosis in dengue hemorrhagic fever: a neglected condition. 53 62
20462096 2010
2
Can we prevent blood dyscrasia (leucopenia, thrombocytopenia) and epileptic seizures induced by clozapine. 53 62
20305597 2010
3
Agranulocytosis following phenytoin-induced hypersensitivity syndrome. 53 62
18774664 2009
4
Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. 53 62
18613811 2008
5
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. 53 62
18489081 2008
6
Use of granulocyte colony-stimulating factor (G-CSF) and outcome in patients with non-chemotherapy agranulocytosis. 53 62
18181220 2008
7
Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. 53 62
17602675 2007
8
The impact of long-term haemofiltration (continuous veno-venous haemofiltration) on cell-mediated immunity during endotoxaemia. 53 62
17567268 2007
9
[Docetaxel in the treatment of advanced breast cancer ]. 53 62
17152498 2006
10
Risk of clozapine-associated agranulocytosis and mandatory white blood cell monitoring. 53 62
16595571 2006
11
[Idiosyncratic drug-induced agranulocytosis]. 53 62
16043267 2006
12
Granulocyte-Colony Stimulating Factor (G-CSF) Therapy in Antithyroid Drug-induced Agranulocytosis. 53 62
16006735 2005
13
Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? 53 62
15785251 2005
14
Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis. 53 62
15644577 2004
15
Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. 53 62
15538122 2004
16
Long-term outcome of patients treated with hematopoietic growth factors for idiosyncratic drug-induced agranulocytosis. 53 62
14984824 2004
17
NQO2 gene is associated with clozapine-induced agranulocytosis. 53 62
14617031 2003
18
[Agranulocytosis and acute coronary syndrome in apathetic hyperthyroidism]. 53 62
14692133 2003
19
Long-term combination treatment with clozapine and filgrastim in patients with clozapine-induced agranulocytosis. 53 62
12702898 2003
20
Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor. 53 62
12661801 2003
21
Prospective randomized trial to evaluate two delayed granulocyte colony stimulating factor administration schedules after high-dose cytarabine therapy in adult patients with acute lymphoblastic leukemia. 53 62
12424538 2002
22
Hematopoietic growth factors in drug-induced agranulocytosis. 53 62
12186123 2002
23
Nonchemotherapy drug-induced agranulocytosis in elderly patients: the effects of granulocyte colony-stimulating factor. 53 62
11959056 2002
24
Agranulocytosis associated with lamotrigine in a patient with low-grade glioma. 53 62
11903469 2002
25
Sudden termination of G-CSF injection leads to apoptosis of a large proportion of increased granulocytes. 53 62
11496310 2001
26
Fludarabine in combination with cyclophosphamide or with cyclophosphamide plus mitoxantrone for relapsed or refractory low-grade non-Hodgkin's lymphoma. 53 62
11255275 2001
27
G-CSF plasma levels in clozapine-induced neutropenia. 53 62
11094146 2000
28
Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. 53 62
11147929 2000
29
Effects of interferon-alpha on peripheral neutrophil counts and serum granulocyte colony-stimulating factor levels in chronic hepatitis C patients. 53 62
11140884 2000
30
Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. 53 62
10937789 2000
31
Ticlopidine-induced severe agranulocytosis after the placement of coronary artery stent--a case report. 53 62
10917583 2000
32
[Do hematopoietic growth factors have a role in the treatment of drug-induced agranulocytosis?]. 53 62
10942973 2000
33
The effect of CVVHD and endotoxin on the oxidative burst, adhesion molecules and distribution in tissues of granulocytes. 53 62
10945396 2000
34
Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro. 53 62
10792393 2000
35
[Agranulocytosis in acute hepatitis B in an HIV seropositive patient]. 53 62
10738502 2000
36
Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. 53 62
10739170 2000
37
Analysis of TH1 and TH2 cells by intracellular cytokine detection with flow cytometry in patients with ovarian cancer. 53 62
11014957 2000
38
Treatment of antithyroid drug-induced agranulocytosis by granulocyte colony-stimulating factor: a case of primum non nocere. 53 62
10560960 1999
39
The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis. 53 62
10695110 1999
40
Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancer. 53 62
10071282 1999
41
Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. 53 62
10221368 1999
42
Treatment of drug-induced agranulocytosis with haematopoietic growth factors: a review of the clinical experience. 53 62
18031129 1999
43
Granulocyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis: a prospective study. 53 62
10037073 1999
44
Fever or a soar throat after start of antithyroidal drugs? A medical emergency. 53 62
9803142 1998
45
A multi-center safety trial of the oral iron chelator deferiprone. 53 62
9668543 1998
46
Elevated serum granulocyte colony-stimulating factor levels in patients with Graves' disease. 53 62
9578815 1998
47
Successful treatment of a patient with Graves' disease on hemodialysis complicated by antithyroid drug-induced granulocytopenia and angina pectoris. 53 62
9292952 1997
48
Usefulness of granulocyte count measurement four hours after injection of granulocyte colony-stimulating factor for detecting recovery from antithyroid drug-induced granulocytopenia. 53 62
9292945 1997
49
The influence of clozapine treatment on plasma granulocyte colony-stimulating (G-CSF) levels. 53 62
9271776 1997
50
Recombinant human granulocyte colony-stimulating factor in treatment of methimazole-induced agranulocytosis. 53 62
15251798 1997

Variations for Granulocytopenia

Expression for Granulocytopenia

Search GEO for disease gene expression data for Granulocytopenia.

Pathways for Granulocytopenia

Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 CSF2 CSF3 IL3 ITGAM ITGB2 MPO
2
Show member pathways
13.04 ITGB2 ITGAM IL3 CSF3 CSF2
3
Show member pathways
12.88 ITGB2 ITGAM IL3 CSF3 CSF2
4
Show member pathways
11.78 SELL ITGB2 ITGAM
5 11.43 ITGB2 ITGAM IL3
6 11.37 SELL ITGAM CSF2
7 11.24 ITGB2 ITGAM
8 11.22 CSF3 CSF2
9 11.18 ITGB2 ITGAM
10 11.16 ITGB2 ITGAM
11 11.16 SELL MPO ITGAM IL3 CSF3 CSF2
12 11.1 ITGB2 ITGAM
13 10.94 ITGB2 ITGAM
14 10.92 ITGB2 ITGAM
15 10.59 IL3 CSF3 CSF2
16 10.56 ITGB2 ITGAM IL3 CSF3 CSF2
17 9.63 NAT2 MPO

GO Terms for Granulocytopenia

Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle lumen GO:0071682 9.26 HYOU1 CSF3
2 integrin alphaM-beta2 complex GO:0034688 8.92 ITGB2 ITGAM

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microglial cell activation GO:0001774 9.67 ITGB2 ITGAM
2 positive regulation of superoxide anion generation GO:0032930 9.62 ITGB2 ITGAM
3 amyloid-beta clearance GO:0097242 9.56 ITGB2 ITGAM
4 positive regulation of neutrophil degranulation GO:0043315 9.46 ITGB2 ITGAM
5 positive regulation of prostaglandin-E synthase activity GO:2000363 9.26 ITGB2 ITGAM
6 negative regulation of dopamine metabolic process GO:0045963 8.92 ITGB2 ITGAM

Molecular functions related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cargo receptor activity GO:0038024 9.26 ITGB2 ITGAM
2 complement component C3b binding GO:0001851 8.92 ITGB2 ITGAM

Sources for Granulocytopenia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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