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MCID: GRN017
MIFTS: 42

Granulocytopenia

Categories: Blood diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Granulocytopenia

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MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia 20
Agranulocytosis 70 32

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 D70
UMLS 70 C0001824
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Summaries for Granulocytopenia

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MalaCards based summary : Granulocytopenia, also known as agranulocytosis, is related to neutropenia, severe congenital, 3, autosomal recessive and cyclic neutropenia. An important gene associated with Granulocytopenia is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Iron and Deferiprone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, neutrophil and myeloid, and related phenotype is immune system.

Wikipedia : 73 Granulocytes are a category of white blood cells in the innate immune system characterized by the... more...

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Related Diseases for Granulocytopenia

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Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 535)
# Related Disease Score Top Affiliating Genes
1 neutropenia, severe congenital, 3, autosomal recessive 32.3 IL3 CSF3 CSF2
2 cyclic neutropenia 31.3 TNF IL3 CSF3 CSF2
3 felty syndrome 30.3 IL3 CSF3 CSF2
4 thrombocytosis 30.3 IL3 CSF3 CSF2
5 shwartzman phenomenon 30.2 TNF ITGAM
6 leukostasis 30.2 TNF SELL MPO
7 acute leukemia 30.2 MPO IL3 CSF3 CSF2
8 aspergillosis 30.2 TNF CSF3 CSF2
9 cellulitis 30.1 TNF CSF3 CSF2
10 pancytopenia 30.1 IL3 CSF3 CSF2 CP
11 mucormycosis 30.1 CSF3 CSF2
12 pulmonary tuberculosis 30.0 TNF NAT2 CP
13 soft tissue sarcoma 30.0 TNF CSF3
14 miliary tuberculosis 29.9 TNF CSF3
15 stomatitis 29.9 TNF CSF3 CSF2
16 gingivitis 29.8 TNF MPO CSF3
17 lymphoma, hodgkin, classic 29.8 IL3 CSF3 CSF2
18 neutrophilic dermatosis, acute febrile 29.8 TNF MPO CSF3
19 appendicitis 29.7 TNF MPO CSF3
20 pneumonia 29.7 TNF SELL MPO ITGAM CSF3
21 hypereosinophilic syndrome 29.7 MPO IL3 CSF2
22 exanthem 29.7 TNF CSF3 CSF2
23 allergic disease 29.7 TNF MPO IL3 CSF2
24 mucositis 29.6 IL3 CSF3 CSF2
25 neutropenia 29.6 TNF MPO ITGAM IL3 CSF3 CSF2
26 brucellosis 29.6 TNF SELL MPO
27 meningitis 29.6 TNF CSF3 CSF2
28 fungal infectious disease 29.6 TNF CSF3 CSF2
29 pyoderma 29.5 TNF ITGB2 CSF3
30 myeloid leukemia 29.5 MPO ITGAM IL3 CSF3 CSF2
31 bilirubin metabolic disorder 29.5 TNF CSF3 CP
32 lymphoma, non-hodgkin, familial 29.4 SELL ITGAM IL3 CSF3 CSF2
33 aplastic anemia 29.4 TNF MPO IL3 CSF3 CSF2
34 leukemia, chronic myeloid 29.4 MPO IL3 CSF3 CSF2
35 leukemia, acute lymphoblastic 29.4 SELL MPO ITGAM IL3 CSF3 CSF2
36 deficiency anemia 29.3 TNF NAT2 IL3 CSF3 CSF2 CP
37 mycobacterium tuberculosis 1 29.3 TNF SELL NAT2 ITGAM
38 pyoderma gangrenosum 29.3 TNF ITGB2 CSF3
39 gastroenteritis 29.3 TNF IL3 CSF3 CSF2
40 chronic granulomatous disease 29.3 TNF MPO CSF3 CSF2
41 myeloma, multiple 29.2 TNF IL3 CSF3 CSF2
42 adult respiratory distress syndrome 29.2 TNF MPO ITGAM CSF3 CP
43 vascular disease 29.2 TNF MPO ITGAM CSF3
44 acne 29.2 TNF MPO ITGB2
45 leukemia, acute myeloid 29.2 TNF MPO ITGAM IL3 CSF3 CSF2
46 leishmaniasis 29.2 TNF ITGB2 ITGAM
47 severe congenital neutropenia 29.2 TNF MPO IL3 CSF3 CSF2
48 thrombocytopenia 29.2 TNF SELL ITGB2 ITGAM IL3 CSF3
49 myelofibrosis 29.1 TNF MPO ITGAM IL3 CSF3
50 lung disease 29.1 TNF MPO CSF3 CSF2

Graphical network of the top 20 diseases related to Granulocytopenia:



Diseases related to Granulocytopenia
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Symptoms & Phenotypes for Granulocytopenia

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MGI Mouse Phenotypes related to Granulocytopenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.32 CP CSF2 CSF3 ITGAM ITGB2 LAP3
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Drugs & Therapeutics for Granulocytopenia

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Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3 7439-89-6 23925 29936
2
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
3
Deferasirox Approved, Investigational Phase 2, Phase 3 201530-41-8 5493381 214348
4
Deferoxamine Approved, Investigational Phase 2, Phase 3 70-51-9 2973
5 Chelating Agents Phase 2, Phase 3
6 Iron Chelating Agents Phase 2, Phase 3
7
Caspofungin Approved Phase 2 162808-62-0, 179463-17-3 468682 2826718
8
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
9
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
10
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
11
Epirubicin Approved Phase 2 56420-45-2 41867
12
Altretamine Approved Phase 2 645-05-6 2123
13
Lenograstim Approved, Investigational Phase 2 135968-09-1
14
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
15
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
16 Antifungal Agents Phase 2
17 Anti-Infective Agents Phase 2
18 Adjuvants, Immunologic Phase 2
19 Immunologic Factors Phase 2
20
Iodine Approved, Investigational 7553-56-2 807
21
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
22
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
23 Liver Extracts
24 Antithyroid Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Randomized Comparative Study of Efficacy and Safety of Combined Deferiprone (DFP) and Deferasirox Versus DFP and Desferrioxamine (DFO) Therapy in Diseases With Severe Iron Overload Unknown status NCT01511848 Phase 2, Phase 3 DFP (ferriprox) and deferasirox (ICL 670);DFP, DFO
2 An Open，Multicenter Clinic Trial of the Effectiveness，Safety and Pharmacokinetics in the Empiric Therapy of Patients With Persistent Fever and Agranulocytosis Using Local Caspofungin Completed NCT03857399 Phase 2 Caspofungin
3 Efficacy and Safety Phase II Study of Recombinant Human Serum Albumin/Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Patients Completed NCT02465801 Phase 2 HSA-GCSF 1.2 mg;HSA-GCSF 1.5 mg;GCSF
4 Efficacy and Safety Phase IIb Study of Recombinant Human Serum Albumin/ Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Breast Cancer Patients Completed NCT03251768 Phase 2 rHSA-GCSF 2.4mg;GCSF
5 Efficacy and Safety Phase Ib Study of Recombinant Human Serum Albumin/ Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Patients Completed NCT03246009 Phase 1 rHSA/GCSF;rHSA/GCSF;rHSA/GCSF;rHSA/GCSF;rHSA/GCSF;rHSA/GCSF
6 Etiology of Blood Dyscrasias: Analysis of the International Agranulocytosis and Aplastic Anemia Study Data Completed NCT00005307
7 Effectiveness of Classical Potassium Iodide Therapy for the Treatment of Untreated Patients With Graves' Hyperthyroidism, Avoiding Thionamide Drugs With Serious Side Effects of Agranulocytosis, Liver Injury, Vasculitis, Embryopathy or Frequent Side Effects of Skin Eruption Completed NCT04686006 Potassium Iodide
8 Drug Etiology of Aplastic Anemia and Related Dyscrasias Completed NCT00005302
9 Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent Completed NCT00059423
10 Genetic Study of Antithyroid Drugs Associated Agranulocytosis Recruiting NCT01977963

Search NIH Clinical Center for Granulocytopenia

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Genetic Tests for Granulocytopenia

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Anatomical Context for Granulocytopenia

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MalaCards organs/tissues related to Granulocytopenia:

40
Bone Marrow, Neutrophil, Myeloid, Liver, Lung, Bone, Cervix
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Publications for Granulocytopenia

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Articles related to Granulocytopenia:

(show top 50) (show all 6563)
# Title Authors PMID Year
1
Agranulocytosis in dengue hemorrhagic fever: a neglected condition. 61 54
20462096 2010
2
Can we prevent blood dyscrasia (leucopenia, thrombocytopenia) and epileptic seizures induced by clozapine. 61 54
20305597 2010
3
Agranulocytosis following phenytoin-induced hypersensitivity syndrome. 61 54
18774664 2009
4
Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. 61 54
18613811 2008
5
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. 61 54
18489081 2008
6
Use of granulocyte colony-stimulating factor (G-CSF) and outcome in patients with non-chemotherapy agranulocytosis. 61 54
18181220 2008
7
Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. 54 61
17602675 2007
8
The impact of long-term haemofiltration (continuous veno-venous haemofiltration) on cell-mediated immunity during endotoxaemia. 61 54
17567268 2007
9
[Docetaxel in the treatment of advanced breast cancer ]. 54 61
17152498 2006
10
Risk of clozapine-associated agranulocytosis and mandatory white blood cell monitoring. 61 54
16595571 2006
11
[Idiosyncratic drug-induced agranulocytosis]. 61 54
16043267 2006
12
Granulocyte-Colony Stimulating Factor (G-CSF) Therapy in Antithyroid Drug-induced Agranulocytosis. 54 61
16006735 2005
13
Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? 54 61
15785251 2005
14
Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis. 54 61
15644577 2004
15
Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. 54 61
15538122 2004
16
Long-term outcome of patients treated with hematopoietic growth factors for idiosyncratic drug-induced agranulocytosis. 61 54
14984824 2004
17
NQO2 gene is associated with clozapine-induced agranulocytosis. 61 54
14617031 2003
18
[Agranulocytosis and acute coronary syndrome in apathetic hyperthyroidism]. 54 61
14692133 2003
19
Long-term combination treatment with clozapine and filgrastim in patients with clozapine-induced agranulocytosis. 54 61
12702898 2003
20
Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor. 54 61
12661801 2003
21
Prospective randomized trial to evaluate two delayed granulocyte colony stimulating factor administration schedules after high-dose cytarabine therapy in adult patients with acute lymphoblastic leukemia. 54 61
12424538 2002
22
Hematopoietic growth factors in drug-induced agranulocytosis. 54 61
12186123 2002
23
Nonchemotherapy drug-induced agranulocytosis in elderly patients: the effects of granulocyte colony-stimulating factor. 54 61
11959056 2002
24
Agranulocytosis associated with lamotrigine in a patient with low-grade glioma. 54 61
11903469 2002
25
Sudden termination of G-CSF injection leads to apoptosis of a large proportion of increased granulocytes. 54 61
11496310 2001
26
Fludarabine in combination with cyclophosphamide or with cyclophosphamide plus mitoxantrone for relapsed or refractory low-grade non-Hodgkin's lymphoma. 54 61
11255275 2001
27
G-CSF plasma levels in clozapine-induced neutropenia. 61 54
11094146 2000
28
Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. 61 54
11147929 2000
29
Effects of interferon-alpha on peripheral neutrophil counts and serum granulocyte colony-stimulating factor levels in chronic hepatitis C patients. 61 54
11140884 2000
30
Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. 61 54
10937789 2000
31
[Do hematopoietic growth factors have a role in the treatment of drug-induced agranulocytosis?]. 61 54
10942973 2000
32
Ticlopidine-induced severe agranulocytosis after the placement of coronary artery stent--a case report. 61 54
10917583 2000
33
The effect of CVVHD and endotoxin on the oxidative burst, adhesion molecules and distribution in tissues of granulocytes. 61 54
10945396 2000
34
Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro. 61 54
10792393 2000
35
[Agranulocytosis in acute hepatitis B in an HIV seropositive patient]. 61 54
10738502 2000
36
Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. 61 54
10739170 2000
37
Analysis of TH1 and TH2 cells by intracellular cytokine detection with flow cytometry in patients with ovarian cancer. 54 61
11014957 2000
38
Treatment of antithyroid drug-induced agranulocytosis by granulocyte colony-stimulating factor: a case of primum non nocere. 54 61
10560960 1999
39
The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis. 61 54
10695110 1999
40
Treatment of drug-induced agranulocytosis with haematopoietic growth factors: a review of the clinical experience. 54 61
18031129 1999
41
Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. 54 61
10221368 1999
42
Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancer. 61 54
10071282 1999
43
Granulocyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis: a prospective study. 61 54
10037073 1999
44
Fever or a soar throat after start of antithyroidal drugs? A medical emergency. 54 61
9803142 1998
45
A multi-center safety trial of the oral iron chelator deferiprone. 54 61
9668543 1998
46
Elevated serum granulocyte colony-stimulating factor levels in patients with Graves' disease. 61 54
9578815 1998
47
Successful treatment of a patient with Graves' disease on hemodialysis complicated by antithyroid drug-induced granulocytopenia and angina pectoris. 61 54
9292952 1997
48
Usefulness of granulocyte count measurement four hours after injection of granulocyte colony-stimulating factor for detecting recovery from antithyroid drug-induced granulocytopenia. 61 54
9292945 1997
49
Recombinant human granulocyte colony-stimulating factor in treatment of methimazole-induced agranulocytosis. 54 61
15251798 1997
50
The influence of clozapine treatment on plasma granulocyte colony-stimulating (G-CSF) levels. 54 61
9271776 1997
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Variations for Granulocytopenia

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Expression for Granulocytopenia

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Search GEO for disease gene expression data for Granulocytopenia.
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Pathways for Granulocytopenia

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Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 63
Show member pathways
 13.24 TNF ITGB2 ITGAM IL3 CSF3 CSF2
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.2 TNF ITGB2 ITGAM IL3 CSF3 CSF2
3
NF-kappaB Signaling 4
12.41 TNF MPO ITGB2 IL3
4
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.36 TNF ITGB2 IL3 CSF2
5
Transcriptional misregulation in cancer 36
12.11 MPO ITGAM IL3 CSF2
6
Phagosome 36
11.99 MPO ITGB2 ITGAM
7
Cell adhesion molecules 36
11.97 SELL ITGB2 ITGAM
8
Interleukin-4 and 13 signaling 65
11.83 TNF ITGB2 ITGAM
9
Rheumatoid arthritis 36
11.72 TNF ITGB2 CSF2
10
Amoebiasis 36
11.71 TNF ITGB2 ITGAM CSF2
11
Pertussis 36
11.62 TNF ITGB2 ITGAM
12
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.61 TNF IL3 CSF2
13
Hematopoietic cell lineage 36
11.55 TNF ITGAM IL3 CSF3 CSF2
14
Dendritic Cells Developmental Lineage Pathway 64
11.54 TNF SELL ITGAM CSF2
15
Lung fibrosis 1
11.52 TNF CSF3 CSF2
16
Legionellosis 36
11.47 TNF ITGB2 ITGAM
17
Acute myeloid leukemia 36
11.45 MPO ITGAM IL3 CSF2
18
Malaria 36
11.39 TNF ITGB2 CSF3
19
Interleukin-10 signaling 65
11.36 TNF CSF3 CSF2
20
MSP-RON Signaling 63
11.33 TNF ITGB2 ITGAM
21
Hematopoietic Stem Cell Differentiation 1
11.31 IL3 CSF3 CSF2
22
amb2 Integrin signaling 1
11.24 TNF MPO ITGB2 ITGAM
23
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.23 TNF SELL MPO ITGAM IL3 CSF3
24
LDL Oxidation in Atherogenesis 63
10.81 TNF MPO
25
G-protein signaling_Rap2B regulation pathway 23
10.81 TNF ITGB2 ITGAM IL3 CSF3 CSF2
26
Cytokines and Inflammatory Response 1
10.72 TNF IL3 CSF3 CSF2
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GO Terms for Granulocytopenia

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Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TNF MPO IL3 HYOU1 CSF3 CSF2
2 extracellular exosome GO:0070062 9.76 NQO2 MPO LAP3 ITGB2 ITGAM HYOU1
3 extracellular space GO:0005615 9.56 TNF MPO ITGAM IL3 CSF3 CSF2
4 integrin alphaM-beta2 complex GO:0034688 8.62 ITGB2 ITGAM

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.71 TNF SELL ITGB2 ITGAM
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 TNF IL3 CSF2
3 leukocyte tethering or rolling GO:0050901 9.54 TNF SELL
4 positive regulation of superoxide anion generation GO:0032930 9.52 ITGB2 ITGAM
5 toll-like receptor 4 signaling pathway GO:0034142 9.51 ITGB2 ITGAM
6 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.49 TNF ITGB2
7 amyloid-beta clearance GO:0097242 9.48 ITGB2 ITGAM
8 positive regulation of podosome assembly GO:0071803 9.46 TNF CSF2
9 cellular extravasation GO:0045123 9.37 TNF ITGB2
10 negative regulation of dopamine metabolic process GO:0045963 9.32 ITGB2 ITGAM
11 positive regulation of neutrophil degranulation GO:0043315 9.26 ITGB2 ITGAM
12 positive regulation of prostaglandin-E synthase activity GO:2000363 9.16 ITGB2 ITGAM
13 microglial cell activation GO:0001774 9.13 TNF ITGB2 ITGAM
14 cytokine-mediated signaling pathway GO:0019221 9.1 TNF ITGB2 ITGAM IL3 CSF3 CSF2

Molecular functions related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL3 CSF3 CSF2
2 cargo receptor activity GO:0038024 9.16 ITGB2 ITGAM
3 complement component C3b binding GO:0001851 8.62 ITGB2 ITGAM
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Sources for Granulocytopenia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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