MCID: GRN017
MIFTS: 46

Granulocytopenia

Categories: Rare diseases

Aliases & Classifications for Granulocytopenia

MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia 53
Agranulocytosis 73

Classifications:



External Ids:

UMLS 73 C0001824

Summaries for Granulocytopenia

MalaCards based summary : Granulocytopenia, also known as agranulocytosis, is related to acute leukemia and cohen syndrome. An important gene associated with Granulocytopenia is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Cisplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, bone and bone marrow, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Granulocytes are a category of white blood cells characterized by the presence of granules in their... more...

Related Diseases for Granulocytopenia

Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 acute leukemia 32.2 CSF3 IL3 MPO
2 cohen syndrome 30.3 ITGAM SELL
3 leukostasis 30.2 MPO SELL
4 shwartzman phenomenon 29.9 ITGAM TNF
5 vasculitis 29.9 MPO SELL TNF
6 anca-associated vasculitis 29.8 MPO TNF
7 stomatitis 29.7 CSF2 CSF3 TNF
8 neutropenia 29.7 CSF2 CSF3 IL3
9 chronic granulomatous disease 29.6 CSF2 CSF3 MPO
10 aplastic anemia 29.5 CSF2 CSF3 IL3 TNF
11 acute promyelocytic leukemia 29.1 CSF3 IL3 ITGAM ITGB2 MPO
12 granulocytopenia with immunoglobulin abnormality 12.1
13 leukemia 10.3
14 thrombocytopenia 10.3
15 boutonneuse fever 10.2 CP SELL
16 retinitis pigmentosa 60 10.2 SELL TNF
17 penicilliosis 10.2 ITGAM TNF
18 engraftment syndrome 10.2 CSF2 CSF3
19 1,4-phenylenediamine allergic contact dermatitis 10.1 NAT2 TNF
20 chronic pulmonary heart disease 10.1 CP TNF
21 autoimmune inner ear disease 10.1 MPO TNF
22 chronic monocytic leukemia 10.1 ITGAM MPO
23 arthus reaction 10.1 SELL TNF
24 seborrheic infantile dermatitis 10.1 CSF2 IL3
25 burns 10.1 CSF2 TNF
26 microscopic polyangiitis 10.1 MPO TNF
27 trichosporonosis 10.1 CSF2 CSF3 TNF
28 stachybotrys chartarum 10.1 IL3 TNF
29 meconium aspiration syndrome 10.1 CSF2 TNF
30 marburg hemorrhagic fever 10.1 NQO2 TNF
31 deficiency anemia 10.1 CP CSF3 IL3
32 monocytic leukemia 10.1 CSF2 ITGAM TNF
33 behcet syndrome 10.1 CP SELL TNF
34 arthritis 10.1
35 felty syndrome 10.1 CSF2 CSF3 IL3
36 cyclic neutropenia 10.1 CSF2 CSF3 IL3
37 anemia of prematurity 10.0 CSF2 CSF3 IL3
38 pleurisy 10.0 MPO SELL TNF
39 peritonitis 10.0 ITGAM MPO TNF
40 pancytopenia 10.0 CSF2 CSF3 IL3
41 severe congenital neutropenia 10.0 CSF2 CSF3 IL3
42 proteasome-associated autoinflammatory syndrome 1 10.0 MPO SELL TNF
43 toxic oil syndrome 10.0 CP NAT2
44 cytomegalovirus retinitis 10.0 CSF2 TNF
45 pneumonia 10.0 CSF3 MPO TNF
46 sarcoidosis 1 10.0 CSF2 IL3 TNF
47 lymphoma 10.0
48 ileitis 10.0 CSF2 MPO TNF
49 essential thrombocythemia 10.0 IL3 ITGAM MPO
50 leukocyte adhesion deficiency, type i 10.0 ITGAM ITGB2 SELL

Graphical network of the top 20 diseases related to Granulocytopenia:



Diseases related to Granulocytopenia

Symptoms & Phenotypes for Granulocytopenia

MGI Mouse Phenotypes related to Granulocytopenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CP CSF2 CSF3 ITGAM ITGB2 MPO
2 immune system MP:0005387 9.32 CP CSF2 CSF3 ITGAM ITGB2 LAP3

Drugs & Therapeutics for Granulocytopenia

Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 716)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
4
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-22-7, 2068-78-2 5978
5
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1 95058-81-4 60750
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
8
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
9
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 59-05-2, 1959-05-2 126941
10
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
11
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 43805 6857599 5310940 9887054
12
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56420-45-2 41867
13
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
14
Cilastatin Approved, Investigational Phase 4,Not Applicable 82009-34-5 6435415 5280454
15
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7 64778 441130
16
Imipenem Approved Phase 4,Not Applicable 74431-23-5, 64221-86-9 104838
17
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
18
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
19
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
20
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 14969 441141
21
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
22
Ceftazidime Approved Phase 4,Phase 3,Phase 2 78439-06-2, 72558-82-8 5481173
23
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
24
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
25
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 85721-33-1 2764
26
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
27
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
28
Iron Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7439-89-6 23925
29
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 2 73590-58-6 4594
30
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
31
Docetaxel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 114977-28-5 148124
32
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
33
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
34
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
35
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
36
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
37
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 302-25-0
38
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1 2921-57-5
39
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
40
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
41
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
42
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
43
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
44
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
45
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
46
Valganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 175865-60-8 64147
47
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
48
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
49
Vinblastine Approved Phase 4,Phase 2,Phase 3,Phase 1 865-21-4 241903 13342
50
Levofloxacin Approved, Investigational Phase 4,Phase 3,Not Applicable 100986-85-4 149096

Interventional clinical trials:

(show top 50) (show all 1468)
# Name Status NCT ID Phase Drugs
1 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Unknown status NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
2 Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO Unknown status NCT02149329 Phase 4 Discontinuation of imipenem-cilastatin or meropenem
3 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
4 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
5 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
6 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Unknown status NCT02905916 Phase 4 PEG-rhG-CSF
7 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
8 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Unknown status NCT02967341 Phase 4
9 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
10 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
11 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
12 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
13 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
14 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
15 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
16 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
17 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
18 REaCT Integrated Consent Model to Compare Two Standard of Care Regimens Completed NCT02173262 Phase 4 G-CSF;Ciprofloxacin
19 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
20 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
21 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
22 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
23 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy Completed NCT02805153 Phase 4 PEG-rhG-CSF;rhG-CSF
24 Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy Completed NCT00115206 Phase 4 Neulasta® (pegfilgrastim)
25 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
26 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
27 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
28 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
29 Antifungal Use in Oncohematological Neutropenic Patients Completed NCT00386802 Phase 4 Antifungal drug. VORICONAZOL. (VFEND®)
30 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Completed NCT02621905 Phase 4 Sporanox;Lozanoc
31 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
32 Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer Completed NCT00883675 Phase 4 Docetaxel-Carboplatin
33 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
34 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
35 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4 CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
36 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4 PEG-rhG-CSF
37 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
38 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
39 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
40 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
41 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
42 Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT Completed NCT01232504 Phase 4 rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
43 The Efficacy and Safety Study of Fuganlin Oral Liquid in Children With Influenza (Acute Upper Respiratory Infection) Completed NCT02622659 Phase 4 Fuganlin Oral Liquid;Xiaoer Jiebiao Oral Liquid
44 Oral Zinc Therapy for the Prevention of Mucositis Completed NCT00449592 Phase 4 Zinc;Placebo
45 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
46 Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours Completed NCT00220168 Phase 4 Irinotecan, Capecitabine
47 Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A Completed NCT02328963 Phase 4 Everolimus;mycophenolic acid
48 VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel Completed NCT01684813 Phase 4 Prasugrel.;Clopidogrel
49 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
50 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]

Search NIH Clinical Center for Granulocytopenia

Genetic Tests for Granulocytopenia

Anatomical Context for Granulocytopenia

MalaCards organs/tissues related to Granulocytopenia:

41
Neutrophil, Bone, Bone Marrow, Liver, T Cells, Myeloid, Breast

Publications for Granulocytopenia

Articles related to Granulocytopenia:

(show top 50) (show all 1178)
# Title Authors Year
1
50 Years Ago in The Journal of Pediatrics: Familial Granulocytopenia and Associated Immunoglobulin Abnormality: Report of 3 Cases in Young Brothers. ( 29478506 )
2018
2
Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring. ( 28984748 )
2018
3
Clozapine-Associated Cytomegalovirus Colitis and Related Critical Illness in a Patient With Neither Neutropenia Nor Agranulocytosis. ( 30280578 )
2018
4
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters. ( 29789870 )
2018
5
Agranulocytosis and Good Syndrome in Patient with Thymoma-The Role of Immunosuppressive Treatment after Thymectomy. ( 30166018 )
2018
6
Granulocytopenia. ( 30193521 )
2018
7
A case of antithyroid drug-induced agranulocytosis from a second antithyroid drugs (ATD) administration in a relapsed Graves' disease patient who was tolerant to the first ATD treatment. ( 30214745 )
2018
8
Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. ( 29552362 )
2018
9
Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. ( 30364514 )
2018
10
Agranulocytosis Associated with Waldenström Macroglobulinemia. ( 30114687 )
2018
11
Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky. ( 30549484 )
2018
12
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis. ( 30319405 )
2018
13
Agranulocytosis associated with voriconazole-induced hypersensitivity syndrome. ( 29168223 )
2018
14
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. ( 30328081 )
2018
15
Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus. ( 28762467 )
2018
16
Thiamazole-Induced Agranulocytosis Leading to Abscessus Pneumonia-Rare, But Challenging. ( 29203051 )
2018
17
Decreased miR-17-92 cluster expression level in serum and granulocytes preceding onset of antithyroid drug-induced agranulocytosis. ( 29255972 )
2018
18
Safety of dipyrone (metamizole) in children-What's the risk of agranulocytosis? ( 29345086 )
2018
19
Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature. ( 29404875 )
2018
20
Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?" ( 29436141 )
2018
21
Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases. ( 29545956 )
2018
22
Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor. ( 29560017 )
2018
23
A Case of Levamisole-Induced Agranulocytosis. ( 29607229 )
2018
24
Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept. ( 29633650 )
2018
25
Transient immune-mediated agranulocytosis following Mycoplasma pneumoniae infection. ( 29669774 )
2018
26
Recurrent Levamisole-Induced Agranulocytosis Complicated by Bowel Ischemia in a Cocaine User. ( 29853712 )
2018
27
Clozapine pharmacogenomics: a review of efficacy, pharmacokinetics, and agranulocytosis. ( 29985178 )
2018
28
Erratum to "Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor". ( 30034475 )
2018
29
Zero Eosinophil Count as a Predictor of Clozapine-Associated Late-Onset Agranulocytosis: A Case Report. ( 30113930 )
2018
30
Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients. ( 30123266 )
2018
31
Agranulocytosis Induced by Vancomycin. Case Report and Literature Review. ( 30174327 )
2018
32
Metamizole (dipyrone)-induced agranulocytosis: Does the risk vary according to ethnicity? ( 30311250 )
2018
33
Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population. ( 28161127 )
2017
34
Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice. ( 28101584 )
2017
35
Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative. ( 28392335 )
2017
36
Graves' Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy. ( 29181135 )
2017
37
Clozapine-Associated Neutropenia and Agranulocytosis. ( 29040154 )
2017
38
History and outcome of febrile neutropenia related to non-chemotherapy drugs: A retrospective study of the Strasbourg's agranulocytosis cohort. ( 28823525 )
2017
39
Agranulocytosis occurrence following recent acute infectious mononucleosis. ( 27912922 )
2017
40
Thyroidectomy for the treatment of Graves' thyrotoxicosis in thioamide-induced agranulocytosis and sepsis. ( 28924483 )
2017
41
Methamphetamine Use With Subsequent Thyrotoxicosis/Thyroid Storm, Agranulocytosis, and Modified Total Thyroidectomy: A Case Report. ( 29200896 )
2017
42
Febuxostat-induced agranulocytosis in an end-stage renal disease patient: A case report. ( 28079821 )
2017
43
Incidence and risk estimate of drug-induced agranulocytosis in Hong Kong Chinese. A population-based case-control study. ( 28083886 )
2017
44
Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management. ( 28105610 )
2017
45
Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center. ( 28236218 )
2017
46
Fever, rash and agranulocytosis. ( 28270401 )
2017
47
Dapsone-induced agranulocytosis-possible involvement of low-activity N-acetyltransferase 2. ( 28322460 )
2017
48
More than 25 years of genetic studies of clozapine-induced agranulocytosis. ( 28418011 )
2017
49
Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review. ( 28437295 )
2017
50
Agranulocytosis - Sequelae of Chronic Cocaine Use: Case Series and Literature Review. ( 28589070 )
2017

Variations for Granulocytopenia

Expression for Granulocytopenia

Search GEO for disease gene expression data for Granulocytopenia.

Pathways for Granulocytopenia

Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CSF2 CSF3 IL3 ITGAM ITGB2 TNF
2
Show member pathways
13.2 CSF2 CSF3 IL3 ITGAM ITGB2 TNF
3 12.41 IL3 ITGB2 MPO TNF
4
Show member pathways
12.37 CSF2 IL3 ITGB2 TNF
5
Show member pathways
12.09 ITGAM ITGB2 TNF
6 12.09 CSF2 IL3 ITGAM MPO
7
Show member pathways
12.07 ITGAM ITGB2 SELL
8 12.07 ITGAM ITGB2 TNF
9 11.99 ITGAM ITGB2 MPO
10 11.96 ITGAM ITGB2 SELL
11 11.84 ITGAM ITGB2 TNF
12
Show member pathways
11.83 CSF2 ITGAM ITGB2 TNF
13 11.71 CSF2 ITGB2 TNF
14 11.65 CSF2 ITGAM ITGB2 TNF
15
Show member pathways
11.63 CSF2 IL3 TNF
16 11.62 ITGAM ITGB2 TNF
17 11.53 CSF2 CSF3 TNF
18 11.49 CSF2 ITGAM SELL TNF
19 11.46 ITGAM ITGB2 TNF
20 11.38 CSF2 CSF3 TNF
21 11.36 CSF3 ITGB2 TNF
22 11.34 CSF2 CSF3 IL3 ITGAM TNF
23 11.33 CSF2 CSF3 IL3
24 11.31 ITGAM ITGB2 TNF
25 11.24 ITGAM ITGB2 MPO TNF
26 11.23 CSF2 CSF3 IL3 ITGAM MPO SELL
27 11.07 CSF2 CSF3 IL3 TNF
28 10.92 CSF2 CSF3 IL3 TNF
29 10.82 MPO TNF
30 10.78 CSF2 CSF3 IL3 ITGAM ITGB2 TNF

GO Terms for Granulocytopenia

Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CP CPQ CSF2 CSF3 IL3 MPO
2 extracellular exosome GO:0070062 9.8 CP CPQ ITGAM ITGB2 LAP3 MPO
3 extracellular space GO:0005615 9.56 CP CPQ CSF2 CSF3 IL3 ITGAM
4 external side of plasma membrane GO:0009897 9.46 ITGAM ITGB2 SELL TNF
5 integrin complex GO:0008305 9.4 ITGAM ITGB2
6 plasma membrane raft GO:0044853 9.32 ITGAM ITGB2
7 integrin alphaM-beta2 complex GO:0034688 8.62 ITGAM ITGB2

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 CSF2 CSF3 IL3 TNF
2 neutrophil degranulation GO:0043312 9.88 ITGAM ITGB2 MPO SELL
3 regulation of signaling receptor activity GO:0010469 9.86 CSF2 CSF3 IL3 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.74 CSF2 CSF3 TNF
5 leukocyte migration GO:0050900 9.71 ITGAM ITGB2 SELL TNF
6 positive regulation of protein targeting to membrane GO:0090314 9.58 ITGAM ITGB2
7 leukocyte tethering or rolling GO:0050901 9.55 SELL TNF
8 toll-like receptor 4 signaling pathway GO:0034142 9.54 ITGAM ITGB2
9 positive regulation of superoxide anion generation GO:0032930 9.52 ITGAM ITGB2
10 negative regulation of growth of symbiont in host GO:0044130 9.51 MPO TNF
11 amyloid-beta clearance GO:0097242 9.49 ITGAM ITGB2
12 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.48 ITGAM ITGB2
13 positive regulation of podosome assembly GO:0071803 9.46 CSF2 TNF
14 positive regulation of microglial cell activation GO:1903980 9.43 ITGAM ITGB2
15 cellular extravasation GO:0045123 9.37 ITGB2 TNF
16 negative regulation of dopamine metabolic process GO:0045963 9.32 ITGAM ITGB2
17 positive regulation of neutrophil degranulation GO:0043315 9.26 ITGAM ITGB2
18 positive regulation of prostaglandin-E synthase activity GO:2000363 9.16 ITGAM ITGB2
19 microglial cell activation GO:0001774 9.13 ITGAM ITGB2 TNF
20 cytokine-mediated signaling pathway GO:0019221 9.1 CSF2 CSF3 IL3 ITGAM ITGB2 TNF

Molecular functions related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 CSF2 CSF3 IL3
2 cytokine activity GO:0005125 9.26 CSF2 CSF3 IL3 TNF
3 complement component C3b binding GO:0001851 8.62 ITGAM ITGB2

Sources for Granulocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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