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MCID: GRN017
MIFTS: 52

Granulocytopenia

Categories: Blood diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Granulocytopenia

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MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia 54
Agranulocytosis 74

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

ICD10 34 D70
UMLS 74 C0001824
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Summaries for Granulocytopenia

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MalaCards based summary : Granulocytopenia, also known as agranulocytosis, is related to acute leukemia and cohen syndrome. An important gene associated with Granulocytopenia is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Vincristine and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include breast, lung and myeloid, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Granulocytes are a category of white blood cells characterized by the presence of granules in their... more...

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Related Diseases for Granulocytopenia

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Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 acute leukemia 32.2 CSF3 IL3 MPO
2 cohen syndrome 30.5 ITGAM SELL
3 leukostasis 30.2 MPO SELL
4 shwartzman phenomenon 30.1 ITGAM TNF
5 vasculitis 29.9 MPO SELL TNF
6 stomatitis 29.8 CSF2 CSF3 TNF
7 neutropenia 29.8 CSF2 CSF3 IL3
8 chronic granulomatous disease 29.6 CSF2 CSF3 MPO
9 aplastic anemia 29.5 CSF2 CSF3 IL3 TNF
10 acute promyelocytic leukemia 28.8 CSF3 IL3 ITGAM ITGB2 MPO
11 immunodeficiency 59 and hypoglycemia 11.8
12 leukemia 10.4
13 thrombocytopenia 10.3
14 boutonneuse fever 10.3 CP SELL
15 retinitis pigmentosa 60 10.3 SELL TNF
16 penicilliosis 10.3 ITGAM TNF
17 engraftment syndrome 10.3 CSF2 CSF3
18 chronic pulmonary heart disease 10.2 CP TNF
19 1,4-phenylenediamine allergic contact dermatitis 10.2 NAT2 TNF
20 autoimmune inner ear disease 10.2 MPO TNF
21 chronic monocytic leukemia 10.2 ITGAM MPO
22 arthus reaction 10.2 SELL TNF
23 burns 10.2 CSF2 TNF
24 seborrheic infantile dermatitis 10.2 CSF2 IL3
25 microscopic polyangiitis 10.2 MPO TNF
26 stachybotrys chartarum 10.1 IL3 TNF
27 meconium aspiration syndrome 10.1 CSF2 TNF
28 trichosporonosis 10.1 CSF2 CSF3 TNF
29 marburg hemorrhagic fever 10.1 NQO2 TNF
30 deficiency anemia 10.1 CP CSF3 IL3
31 behcet syndrome 10.1 CP SELL TNF
32 monocytic leukemia 10.1 CSF2 ITGAM TNF
33 arthritis 10.1
34 felty syndrome 10.1 CSF2 CSF3 IL3
35 cyclic neutropenia 10.1 CSF2 CSF3 IL3
36 anemia of prematurity 10.1 CSF2 CSF3 IL3
37 pleurisy 10.1 MPO SELL TNF
38 pancytopenia 10.1 CSF2 CSF3 IL3
39 peritonitis 10.1 ITGAM MPO TNF
40 toxic oil syndrome 10.0 CP NAT2
41 severe congenital neutropenia 10.0 CSF2 CSF3 IL3
42 proteasome-associated autoinflammatory syndrome 1 10.0 MPO SELL TNF
43 cytomegalovirus retinitis 10.0 CSF2 TNF
44 pneumonia 10.0 CSF3 MPO TNF
45 lymphoma 10.0
46 sarcoidosis 1 10.0 CSF2 IL3 TNF
47 scleritis 10.0 ITGB2 TNF
48 ileitis 10.0 CSF2 MPO TNF
49 essential thrombocythemia 9.9 IL3 ITGAM MPO
50 periodontosis 9.9 ITGAM MPO SELL TNF

Graphical network of the top 20 diseases related to Granulocytopenia:



Diseases related to Granulocytopenia
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Symptoms & Phenotypes for Granulocytopenia

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MGI Mouse Phenotypes related to Granulocytopenia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CP CSF2 CSF3 ITGAM ITGB2 MPO
2 immune system MP:0005387 9.32 CP CSF2 CSF3 ITGAM ITGB2 LAP3
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Drugs & Therapeutics for Granulocytopenia

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Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 752)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
2
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
4
Epirubicin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 56420-45-2 41867
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
6
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 6857599 5310940 9887054 43805
7
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 441203 84093 2767
8
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
9
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4, 65-46-3 6253
10
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 23214-92-8 31703
11
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1 95058-81-4 60750
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
13
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
14
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 124-94-7 31307
15
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
16
Ceftazidime Approved Phase 4,Phase 3,Phase 2 78439-06-2, 72558-82-8 5481173
17
Tazobactam Approved Phase 4,Phase 2,Not Applicable 89786-04-9 123630
18
Vancomycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 1404-90-6 441141 14969
19
Meropenem Approved, Investigational Phase 4,Phase 2 119478-56-7, 96036-03-2 441130 64778
20
Piperacillin Approved Phase 4,Phase 2,Not Applicable 66258-76-2 43672
21
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
22
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 477468 3081921
23
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 85721-33-1 2764
24
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
25
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
26
Iron Approved, Experimental Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7439-89-6, 15438-31-0 23925 27284
27
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 2 73590-58-6 4594
28
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
29
Sargramostim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 123774-72-1, 83869-56-1
30
Docetaxel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 114977-28-5 148124
31
leucovorin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-05-9 6006 143
32
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
33
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 38904 10339178 498142
34
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 302-25-0
35
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
36
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1 2921-57-5
37
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
38
Fluorouracil Approved Phase 4,Phase 3,Phase 2,Phase 1 51-21-8 3385
39
Paclitaxel Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
40
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
41
Irinotecan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
42
Capecitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154361-50-9 60953
43
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 46835353 6436030 5284616
44
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177 70789204
45
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 82410-32-0 3454
46
Valganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 175865-60-8 64147
47
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
48
Pemetrexed Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 150399-23-8, 137281-23-3 60843 446556
49
Lenalidomide Approved Phase 4,Phase 1,Phase 2 191732-72-6 216326
50
Levofloxacin Approved, Investigational Phase 4,Phase 3,Not Applicable 100986-85-4 149096

Interventional clinical trials:

(show top 50) (show all 1517)
# Name Status NCT ID Phase Drugs
1 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Unknown status NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
2 Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy Unknown status NCT01571518 Phase 4 late leukostim;early leukostim
3 Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia Unknown status NCT02463747 Phase 4 Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
4 Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer Unknown status NCT00030758 Phase 4
5 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Unknown status NCT02905916 Phase 4 PEG-rhG-CSF
6 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
7 Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients Unknown status NCT02967341 Phase 4
8 Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients Unknown status NCT02605213 Phase 4 Vancomycin;Placebo
9 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
10 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
11 THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS Unknown status NCT02241876 Phase 4 N-acetylcysteine
12 Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia Completed NCT01581333 Phase 4 Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
13 Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia Completed NCT02213783 Phase 4 Imipenem;Imipenem
14 A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen Completed NCT01107756 Phase 4 LENOGRASTIM (GRANOGYTE 34)
15 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia Completed NCT02805205 Phase 4 PEG-rhG-CSF
16 Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer Completed NCT01649635 Phase 4 CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
17 REaCT Integrated Consent Model to Compare Two Standard of Care Regimens Completed NCT02173262 Phase 4 G-CSF;Ciprofloxacin
18 Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome Completed NCT01200355 Phase 4 micafungin;posaconazole
19 Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients Completed NCT01401010 Phase 4 Doripenem;doripenem
20 A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer Completed NCT00277160 Phase 4 Neulasta (pegfilgrastim)
21 FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy Completed NCT00125723 Phase 4
22 PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy Completed NCT02805153 Phase 4 PEG-rhG-CSF;rhG-CSF
23 Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy Completed NCT00115206 Phase 4 Neulasta® (pegfilgrastim)
24 Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients Completed NCT00454272 Phase 4 Teicoplanin;Vancomycin
25 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
26 The Tobramycin Study Completed NCT00257790 Phase 4 Tobramycin once a day
27 Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections Completed NCT00709358 Phase 4
28 Antifungal Use in Oncohematological Neutropenic Patients Completed NCT00386802 Phase 4 Antifungal drug. VORICONAZOL. (VFEND®)
29 Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg Completed NCT02621905 Phase 4 Sporanox;Lozanoc
30 An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL) Completed NCT02782845 Phase 4 Chemotherapy;Immunochemotherapy;Pegfilgrastim
31 Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer Completed NCT00883675 Phase 4 Docetaxel-Carboplatin
32 Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients Completed NCT01114165 Phase 4
33 Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115) Completed NCT00686543 Phase 4 Posaconazole
34 Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer Completed NCT02441894 Phase 4 CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
35 PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy Completed NCT02805166 Phase 4 PEG-rhG-CSF
36 PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy Completed NCT02805218 Phase 4 PEG-rhG-CSF
37 Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-â…¡ Colorectal Cancer Completed NCT02284529 Phase 4 Orectalip
38 Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma Completed NCT00969462 Phase 4 Doxorubicin
39 Multicenter Study of Pharmacokinetic-Guided Docetaxel in Breast Cancer Patients Receiving Docetaxel and Cyclophosphamide Completed NCT02502864 Phase 4 Standard of Care: Docetaxel;Standard of Care: Cyclophosphamide
40 Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection Completed NCT01198236 Phase 4 Itraconazole
41 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Completed NCT02151149 Phase 4 nab-paclitaxel;Carboplatin
42 Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT Completed NCT01232504 Phase 4 rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
43 The Efficacy and Safety Study of Fuganlin Oral Liquid in Children With Influenza (Acute Upper Respiratory Infection) Completed NCT02622659 Phase 4 Fuganlin Oral Liquid;Xiaoer Jiebiao Oral Liquid
44 Oral Zinc Therapy for the Prevention of Mucositis Completed NCT00449592 Phase 4 Zinc;Placebo
45 SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia Completed NCT00487448 Phase 4 Fludarabine;Cytarabine;G-CSF;Idarubicin
46 Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours Completed NCT00220168 Phase 4 Irinotecan, Capecitabine
47 Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A Completed NCT02328963 Phase 4 Everolimus;mycophenolic acid
48 VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel Completed NCT01684813 Phase 4 Prasugrel.;Clopidogrel
49 Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP) Completed NCT00907478 Phase 4
50 A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a) Completed NCT01585324 Phase 4 peginterferon alfa-2a [Pegasys];ribavirin [Copegus]

Search NIH Clinical Center for Granulocytopenia

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Genetic Tests for Granulocytopenia

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Anatomical Context for Granulocytopenia

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MalaCards organs/tissues related to Granulocytopenia:

42
Breast, Lung, Myeloid, Bone, Bone Marrow, Prostate, T Cells
Sources

Publications for Granulocytopenia

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Articles related to Granulocytopenia:

(show top 50) (show all 1660)
# Title Authors Year
1
Increased Risk of Antithyroid Drug Agranulocytosis Associated with Amiodarone-Induced Thyrotoxicosis: A Population-Based Cohort Study. ( 30648930 )
2019
2
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence. ( 30778952 )
2019
3
Agranulocytosis-Protective Olanzapine-Loaded Nanostructured Lipid Carriers Engineered for CNS Delivery: Optimization and Hematological Toxicity Studies. ( 30604305 )
2019
4
Acute agranulocytosis when switching from risperidone to paliperidone. ( 30636434 )
2019
5
Monocytopenia in clozapine-induced agranulocytosis: insights into pathophysiology and treatment. ( 30661042 )
2019
6
Novel Association between Flavin-Containing Monooxygenase 3 Gene Polymorphism and Antithyroid Drug-Induced Agranulocytosis in the Han Population. ( 30814476 )
2019
7
Clozapine-induced agranulocytosis and leukopenia: Incidence, associated factors, and rate of hematologic adverse-effects monitoring in psychiatric out-patient services in Thailand. ( 30856469 )
2019
8
The prevalence of agranulocytosis and related death in clozapine-treated patients: a comprehensive meta-analysis of observational studies. ( 30857568 )
2019
9
Failure of rechallenge clozapine after agranulocytosis: A case report. ( 30878138 )
2019
10
50 Years Ago in The Journal of Pediatrics: Familial Granulocytopenia and Associated Immunoglobulin Abnormality: Report of 3 Cases in Young Brothers. ( 29478506 )
2018
11
Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring. ( 28984748 )
2018
12
Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report. ( 30594147 )
2018
13
Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report. ( 30577288 )
2018
14
Clozapine-Associated Cytomegalovirus Colitis and Related Critical Illness in a Patient With Neither Neutropenia Nor Agranulocytosis. ( 30280578 )
2018
15
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters. ( 29789870 )
2018
16
Agranulocytosis and Good Syndrome in Patient with Thymoma-The Role of Immunosuppressive Treatment after Thymectomy. ( 30166018 )
2018
17
Granulocytopenia. ( 30193521 )
2018
18
A case of antithyroid drug-induced agranulocytosis from a second antithyroid drugs (ATD) administration in a relapsed Graves' disease patient who was tolerant to the first ATD treatment. ( 30214745 )
2018
19
Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. ( 29552362 )
2018
20
Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. ( 30364514 )
2018
21
Recurrent Levamisole-Induced Agranulocytosis Complicated by Bowel Ischemia in a Cocaine User. ( 29853712 )
2018
22
Agranulocytosis Associated with Waldenström Macroglobulinemia. ( 30114687 )
2018
23
Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky. ( 30549484 )
2018
24
Thiamazole-Induced Agranulocytosis Leading to Abscessus Pneumonia-Rare, But Challenging. ( 29203051 )
2018
25
Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis. ( 30319405 )
2018
26
Agranulocytosis associated with voriconazole-induced hypersensitivity syndrome. ( 29168223 )
2018
27
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. ( 30328081 )
2018
28
Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus. ( 28762467 )
2018
29
Decreased miR-17-92 cluster expression level in serum and granulocytes preceding onset of antithyroid drug-induced agranulocytosis. ( 29255972 )
2018
30
Safety of dipyrone (metamizole) in children-What's the risk of agranulocytosis? ( 29345086 )
2018
31
Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature. ( 29404875 )
2018
32
Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?" ( 29436141 )
2018
33
Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases. ( 29545956 )
2018
34
Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor. ( 29560017 )
2018
35
A Case of Levamisole-Induced Agranulocytosis. ( 29607229 )
2018
36
Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept. ( 29633650 )
2018
37
Transient immune-mediated agranulocytosis following Mycoplasma pneumoniae infection. ( 29669774 )
2018
38
Clozapine pharmacogenomics: a review of efficacy, pharmacokinetics, and agranulocytosis. ( 29985178 )
2018
39
Erratum to "Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor". ( 30034475 )
2018
40
Zero Eosinophil Count as a Predictor of Clozapine-Associated Late-Onset Agranulocytosis: A Case Report. ( 30113930 )
2018
41
Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients. ( 30123266 )
2018
42
Agranulocytosis Induced by Vancomycin. Case Report and Literature Review. ( 30174327 )
2018
43
Metamizole (dipyrone)-induced agranulocytosis: Does the risk vary according to ethnicity? ( 30311250 )
2018
44
Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population. ( 28161127 )
2017
45
Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice. ( 28101584 )
2017
46
Graves' Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy. ( 29181135 )
2017
47
Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative. ( 28392335 )
2017
48
History and outcome of febrile neutropenia related to non-chemotherapy drugs: A retrospective study of the Strasbourg's agranulocytosis cohort. ( 28823525 )
2017
49
Clozapine-Associated Neutropenia and Agranulocytosis. ( 29040154 )
2017
50
Agranulocytosis occurrence following recent acute infectious mononucleosis. ( 27912922 )
2017
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Variations for Granulocytopenia

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Expression for Granulocytopenia

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Search GEO for disease gene expression data for Granulocytopenia.
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Pathways for Granulocytopenia

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Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 65
Show member pathways
 13.25 CSF2 CSF3 IL3 ITGAM ITGB2 TNF
2
Cytokine Signaling in Immune system 67
Show member pathways
 13.2 CSF2 CSF3 IL3 ITGAM ITGB2 TNF
3
NF-kappaB Signaling 4
12.41 IL3 ITGB2 MPO TNF
4
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.37 CSF2 IL3 ITGB2 TNF
5
Toxoplasmosis 38
Show member pathways
 12.09 ITGAM ITGB2 TNF
6
Transcriptional misregulation in cancer 38
12.09 CSF2 IL3 ITGAM MPO
7
Cell surface interactions at the vascular wall 67
Show member pathways
 12.07 ITGAM ITGB2 SELL
8
Tuberculosis 38
12.07 ITGAM ITGB2 TNF
9
Phagosome 38
11.99 ITGAM ITGB2 MPO
10
Cell adhesion molecules (CAMs) 38
11.96 ITGAM ITGB2 SELL
11
Interleukin-4 and 13 signaling 67
11.84 ITGAM ITGB2 TNF
12
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.83 CSF2 ITGAM ITGB2 TNF
13
Rheumatoid arthritis 38
11.72 CSF2 ITGB2 TNF
14
Amoebiasis 38
11.65 CSF2 ITGAM ITGB2 TNF
15
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.63 CSF2 IL3 TNF
16
Pertussis 38
11.62 ITGAM ITGB2 TNF
17
Lung fibrosis 1
11.53 CSF2 CSF3 TNF
18
Dendritic Cells Developmental Lineage Pathway 66
11.49 CSF2 ITGAM SELL TNF
19
Legionellosis 38
11.46 ITGAM ITGB2 TNF
20
Interleukin-10 signaling 67
11.38 CSF2 CSF3 TNF
21
Malaria 38
11.36 CSF3 ITGB2 TNF
22
Hematopoietic cell lineage 38
11.34 CSF2 CSF3 IL3 ITGAM TNF
23
Hematopoietic Stem Cell Differentiation 1
11.33 CSF2 CSF3 IL3
24
MSP-RON Signaling 65
11.31 ITGAM ITGB2 TNF
25
amb2 Integrin signaling 1
11.24 ITGAM ITGB2 MPO TNF
26
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.23 CSF2 CSF3 IL3 ITGAM MPO SELL
27
G-protein signaling_RhoB regulation pathway 23
11.07 CSF2 CSF3 IL3 TNF
28
Cytokines and Inflammatory Response 1
10.92 CSF2 CSF3 IL3 TNF
29
LDL Oxidation in Atherogenesis 65
10.82 MPO TNF
30
G-protein signaling_Rap2B regulation pathway 23
10.78 CSF2 CSF3 IL3 ITGAM ITGB2 TNF
Sources

GO Terms for Granulocytopenia

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Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.91 CP CPQ CSF2 CSF3 IL3 MPO
2 extracellular exosome GO:0070062 9.8 CP CPQ ITGAM ITGB2 LAP3 MPO
3 extracellular space GO:0005615 9.56 CP CPQ CSF2 CSF3 IL3 ITGAM
4 external side of plasma membrane GO:0009897 9.46 ITGAM ITGB2 SELL TNF
5 integrin complex GO:0008305 9.4 ITGAM ITGB2
6 plasma membrane raft GO:0044853 9.32 ITGAM ITGB2
7 integrin alphaM-beta2 complex GO:0034688 8.62 ITGAM ITGB2

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.89 CSF2 CSF3 IL3 TNF
2 neutrophil degranulation GO:0043312 9.88 ITGAM ITGB2 MPO SELL
3 regulation of signaling receptor activity GO:0010469 9.86 CSF2 CSF3 IL3 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.74 CSF2 CSF3 TNF
5 leukocyte migration GO:0050900 9.71 ITGAM ITGB2 SELL TNF
6 positive regulation of protein targeting to membrane GO:0090314 9.58 ITGAM ITGB2
7 leukocyte tethering or rolling GO:0050901 9.55 SELL TNF
8 toll-like receptor 4 signaling pathway GO:0034142 9.54 ITGAM ITGB2
9 positive regulation of superoxide anion generation GO:0032930 9.52 ITGAM ITGB2
10 negative regulation of growth of symbiont in host GO:0044130 9.51 MPO TNF
11 amyloid-beta clearance GO:0097242 9.49 ITGAM ITGB2
12 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.48 ITGAM ITGB2
13 positive regulation of podosome assembly GO:0071803 9.46 CSF2 TNF
14 positive regulation of microglial cell activation GO:1903980 9.43 ITGAM ITGB2
15 cellular extravasation GO:0045123 9.37 ITGB2 TNF
16 negative regulation of dopamine metabolic process GO:0045963 9.32 ITGAM ITGB2
17 positive regulation of neutrophil degranulation GO:0043315 9.26 ITGAM ITGB2
18 positive regulation of prostaglandin-E synthase activity GO:2000363 9.16 ITGAM ITGB2
19 microglial cell activation GO:0001774 9.13 ITGAM ITGB2 TNF
20 cytokine-mediated signaling pathway GO:0019221 9.1 CSF2 CSF3 IL3 ITGAM ITGB2 TNF

Molecular functions related to Granulocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 CSF2 CSF3 IL3
2 cytokine activity GO:0005125 9.26 CSF2 CSF3 IL3 TNF
3 complement component C3b binding GO:0001851 8.62 ITGAM ITGB2
Sources

Sources for Granulocytopenia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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