Granulocytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GRN017 MIFTS: 42	Granulocytopenia Categories: Blood diseases, Immune diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Granulocytopenia

MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia ¹⁹ ⁷⁵ ⁷⁵

Agranulocytosis ⁷¹ ³¹

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Other diseases of blood and blood-forming organs

Agranulocytosis

External Ids:

ICD10 ³¹ D70

UMLS ⁷¹ C0001824

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Summaries for Granulocytopenia

GARD: ¹⁹ A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

MalaCards based summary: Granulocytopenia, also known as agranulocytosis, is related to neutropenia, severe congenital, 3, autosomal recessive and cyclic neutropenia. An important gene associated with Granulocytopenia is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Lenograstim and Epirubicin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, neutrophil and bone, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: ⁷⁵ Granulocytes are cells in the innate immune system characterized by the presence of specific granules in... more...

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Related Diseases for Granulocytopenia

Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 580)

#	Related Disease	Score	Top Affiliating Genes
1	neutropenia, severe congenital, 3, autosomal recessive	32.2	IL3 CSF3 CSF2
2	cyclic neutropenia	31.5	IL3 CSF3 CSF2
3	exanthem	30.3	MPO CSF3 CSF2
4	leukostasis	30.2	SELL MPO
5	felty syndrome	30.2	IL3 CSF3 CSF2
6	cellulitis	30.2	CSF3 CSF2
7	thrombocytosis	30.2	IL3 CSF3 CSF2
8	mucormycosis	30.1	CSF3 CSF2
9	acute leukemia	30.1	MPO IL3 CSF3 CSF2
10	cohen syndrome	30.1	SELL ITGAM
11	lymphoma, hodgkin, classic	30.1	IL3 CSF3 CSF2
12	allergic disease	30.0	SELL IL3 CSF2
13	hypersplenism	30.0	CSF3 CSF2
14	pancytopenia	29.9	MPO IL3 CSF3 CSF2
15	pneumonia	29.8	MPO ITGAM CSF3 CSF2
16	neutrophilic dermatosis, acute febrile	29.7	MPO CSF3
17	neutropenia	29.7	SELL MPO ITGAM IL3 CSF3 CSF2
18	hypereosinophilic syndrome	29.7	MPO IL3 CSF2
19	adult respiratory distress syndrome	29.7	SELL MPO ITGAM
20	aplastic anemia	29.6	MPO IL3 CSF3 CSF2
21	venous insufficiency	29.6	SELL ITGAM
22	mucositis	29.6	IL3 CSF3 CSF2
23	severe congenital neutropenia	29.5	MPO IL3 CSF3 CSF2
24	leukemia, chronic myeloid	29.5	MPO IL3 CSF3 CSF2
25	bacterial sepsis	29.5	ITGAM CSF3 CSF2
26	pyoderma	29.5	ITGB2 CSF3
27	gastroenteritis	29.5	IL3 CSF3 CSF2
28	meningitis	29.5	MPO CSF3 CSF2
29	paroxysmal nocturnal hemoglobinuria	29.4	IL3 CSF3 CSF2
30	chronic granulomatous disease	29.4	MPO CSF3 CSF2
31	neutrophilia, hereditary	29.4	MPO IL3 CSF3 CSF2
32	leukemia, acute myeloid	29.4	MPO ITGAM IL3 CSF3 CSF2
33	diarrhea	29.4	MPO IL3 CSF3
34	respiratory failure	29.4	MPO CSF3 CSF2
35	common variable immunodeficiency	29.3	SELL MPO ITGAM
36	thrombocytopenia	29.3	SELL ITGB2 ITGAM IL3 CSF3 CSF2
37	myelofibrosis	29.3	MPO ITGAM IL3 CSF3
38	lymphoma, non-hodgkin, familial	29.3	SELL ITGAM IL3 CSF3 CSF2
39	pyoderma gangrenosum	29.2	ITGB2 CSF3
40	connective tissue disease	29.2	MPO ITGAM CSF3 CSF2
41	polycythemia vera	29.2	MPO IL3 CSF3 CSF2
42	leukemia, acute lymphoblastic	29.2	SELL MPO ITGAM IL3 CSF3 CSF2
43	myeloid leukemia	29.1	MPO IL3 CSF3 CSF2
44	vasculitis	29.1	SELL MPO ITGB2 ITGAM
45	peripheral nervous system disease	29.1	MPO ITGAM CSF3 CSF2
46	leukocyte adhesion deficiency, type i	29.0	SELL ITGB2 ITGAM CSF3
47	leukemia, chronic lymphocytic	28.9	SELL ITGB2 CSF3 CSF2
48	rheumatoid arthritis	28.9	SELL MPO ITGB2 ITGAM CSF2
49	cystic fibrosis	28.8	NAT2 MPO ITGAM CSF3 CSF2
50	immune deficiency disease	28.8	SELL ITGB2 ITGAM CSF2

Graphical network of the top 20 diseases related to Granulocytopenia:

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Symptoms & Phenotypes for Granulocytopenia

MGI Mouse Phenotypes related to Granulocytopenia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.81	CSF2 HYOU1 IL3 ITGAM ITGB2 MPO
2	immune system	MP:0005387	9.56	CSF2 CSF3 IL3 ITGAM ITGB2 MPO
3	hematopoietic system	MP:0005397	9.23	CSF2 CSF3 IL3 ITGAM ITGB2 MPO

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Drugs & Therapeutics for Granulocytopenia

Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Epirubicin

Approved

Phase 2

56420-45-2

41867

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Docetaxel

Approved, Investigational

Phase 2

114977-28-5

148124

Altretamine

Approved

Phase 2

645-05-6

2123

Caspofungin

Approved

Phase 2

179463-17-3, 162808-62-0

2826718

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Adjuvants, Immunologic

Phase 2

Immunologic Factors

Phase 2

Anti-Infective Agents

Phase 2

Antifungal Agents

Phase 2

Iodine

Approved, Investigational

7553-56-2

807

Loncastuximab tesirine

Approved, Investigational

1879918-31-6

Inotuzumab ozogamicin

Approved, Investigational

635715-01-4

Brentuximab vedotin

Approved, Investigational

914088-09-8

Trastuzumab

Approved, Investigational

180288-69-1

Tisotumab vedotin

Approved

1418731-10-8

Dexamethasone acetate

Approved, Investigational, Vet_approved

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

50-02-2

3003 5743

Antithyroid Agents

Liver Extracts

Immunoglobulins, Intravenous

Ado-Trastuzumab Emtansine

Immunoglobulins

Immunoconjugates

Antibodies

Gemtuzumab

Immunotoxin HA22

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy and Safety Phase IIb Study of Recombinant Human Serum Albumin/ Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Breast Cancer Patients	Completed	NCT03251768	Phase 2	rHSA-GCSF 2.4mg;GCSF
2	Efficacy and Safety Phase II Study of Recombinant Human Serum Albumin/Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Patients	Completed	NCT02465801	Phase 2	HSA-GCSF 1.2 mg;HSA-GCSF 1.5 mg;GCSF
3	An Open，Multicenter Clinic Trial of the Effectiveness，Safety and Pharmacokinetics in the Empiric Therapy of Patients With Persistent Fever and Agranulocytosis Using Local Caspofungin	Completed	NCT03857399	Phase 2	Caspofungin
4	Efficacy and Safety Phase Ib Study of Recombinant Human Serum Albumin/ Granulocyte Colony-Stimulating Factor Fusion Protein for Injection to Prevent Neutrophilic Granulocytopenia Among Chemotherapy Patients	Completed	NCT03246009	Phase 1	rHSA/GCSF
5	Genetic Study of Antithyroid Drugs Associated Agranulocytosis	Unknown status	NCT01977963
6	Effectiveness of Classical Potassium Iodide Therapy for the Treatment of Untreated Patients With Graves' Hyperthyroidism, Avoiding Thionamide Drugs With Serious Side Effects of Agranulocytosis, Liver Injury, Vasculitis, Embryopathy or Frequent Side Effects of Skin Eruption	Completed	NCT04686006		Potassium Iodide
7	Etiology of Blood Dyscrasias: Analysis of the International Agranulocytosis and Aplastic Anemia Study Data	Completed	NCT00005307
8	Evaluation of Reporting of Antibody-Drug Conjugate Associated Sepsis-related Toxicities Using International Pharmacovigilance Database	Completed	NCT05349383		Antibody-Drug Conjugate;Antineoplastic and immunomodulating agents other than Antibody-Drug Conjugate
9	Natural History and Molecular Characterization of Benign Ethnic Neutropenia in Individuals of African Descent	Completed	NCT00059423
10	Drug Etiology of Aplastic Anemia and Related Dyscrasias	Completed	NCT00005302

Search NIH Clinical Center for Granulocytopenia

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Genetic Tests for Granulocytopenia

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Anatomical Context for Granulocytopenia

Organs/tissues related to Granulocytopenia:

MalaCards : Bone Marrow, Neutrophil, Bone, Breast, Liver, Lung, Skin

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Publications for Granulocytopenia

Articles related to Granulocytopenia:

(show top 50) (show all 6721)

#	Title	Authors	PMID	Year
1	Agranulocytosis in dengue hemorrhagic fever: a neglected condition. ⁵³ ⁶²	Insiripong S	20462096	2010
2	Can we prevent blood dyscrasia (leucopenia, thrombocytopenia) and epileptic seizures induced by clozapine. ⁵³ ⁶²	Herceg M...Jukic V	20305597	2010
3	Agranulocytosis following phenytoin-induced hypersensitivity syndrome. ⁵³ ⁶²	Ito S...Osawa M	18774664	2009
4	Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. ⁵³ ⁶²	Andres E...Alt M	18613811	2008
5	Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. ⁵³ ⁶²	Siraki AG...Mason RP	18489081	2008
6	Use of granulocyte colony-stimulating factor (G-CSF) and outcome in patients with non-chemotherapy agranulocytosis. ⁵³ ⁶²	Ibanez L...Agranulocytosis and Aplastic Anaemia Study Group of Barcelona	18181220	2008
7	Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. ⁵³ ⁶²	Siraki AG...Mason RP	17602675	2007
8	The impact of long-term haemofiltration (continuous veno-venous haemofiltration) on cell-mediated immunity during endotoxaemia. ⁵³ ⁶²	Toft P...Larsen NH	17567268	2007
9	[Docetaxel in the treatment of advanced breast cancer ]. ⁵³ ⁶²	Wang ZP...Wang ZX	17152498	2006
10	Risk of clozapine-associated agranulocytosis and mandatory white blood cell monitoring. ⁵³ ⁶²	Schulte P	16595571	2006
11	[Idiosyncratic drug-induced agranulocytosis]. ⁵³ ⁶²	Andres E...Groupe d'Etude des Agranulocytoses Medicamenteuses des Hopitaux Universitaires de Strasbourg	16043267	2006
12	Granulocyte-Colony Stimulating Factor (G-CSF) Therapy in Antithyroid Drug-induced Agranulocytosis. ⁵³ ⁶²	Andres E...Maloisel F	16006735	2005
13	Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? ⁵³ ⁶²	Tajiri J...Noguchi S	15785251	2005
14	Serum concentrations of granulocyte colony-stimulating factor (G-CSF) in antithyroid drug-induced agranulocytosis. ⁵³ ⁶²	Murakami Y...Kuma K	15644577	2004
15	Impact of myeloperoxidase and NADPH-oxidase polymorphisms in drug-induced agranulocytosis. ⁵³ ⁶²	Mosyagin I...Cascorbi I	15538122	2004
16	Long-term outcome of patients treated with hematopoietic growth factors for idiosyncratic drug-induced agranulocytosis. ⁵³ ⁶²	Andres E...Maloisel F	14984824	2004
17	NQO2 gene is associated with clozapine-induced agranulocytosis. ⁵³ ⁶²	Ostrousky O...Gazit E	14617031	2003
18	[Agranulocytosis and acute coronary syndrome in apathetic hyperthyroidism]. ⁵³ ⁶²	Ivovic M...Drezgic M	14692133	2003
19	Long-term combination treatment with clozapine and filgrastim in patients with clozapine-induced agranulocytosis. ⁵³ ⁶²	Hagg S...Spigset O	12702898	2003
20	Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor. ⁵³ ⁶²	Joseph F...Bowen-Jones D	12661801	2003
21	Prospective randomized trial to evaluate two delayed granulocyte colony stimulating factor administration schedules after high-dose cytarabine therapy in adult patients with acute lymphoblastic leukemia. ⁵³ ⁶²	Hofmann WK...Hoelzer D	12424538	2002
22	Hematopoietic growth factors in drug-induced agranulocytosis. ⁵³ ⁶²	Pavithran K...Thomas M	12186123	2002
23	Nonchemotherapy drug-induced agranulocytosis in elderly patients: the effects of granulocyte colony-stimulating factor. ⁵³ ⁶²	Andres E...Maloisel Fr	11959056	2002
24	Agranulocytosis associated with lamotrigine in a patient with low-grade glioma. ⁵³ ⁶²	Fadul CE...Lewis LD	11903469	2002
25	Sudden termination of G-CSF injection leads to apoptosis of a large proportion of increased granulocytes. ⁵³ ⁶²	Ogawa Y...Yoshida S	11496310	2001
26	Fludarabine in combination with cyclophosphamide or with cyclophosphamide plus mitoxantrone for relapsed or refractory low-grade non-Hodgkin's lymphoma. ⁵³ ⁶²	Santini G...Gobbi M	11255275	2001
27	G-CSF plasma levels in clozapine-induced neutropenia. ⁵³ ⁶²	Jauss M...Schroder J	11094146	2000
28	Clozapine-induced agranulocytosis and hereditary polymorphisms of clozapine metabolizing enzymes: no association with myeloperoxidase and cytochrome P4502D6. ⁵³ ⁶²	Dettling M...Cascorbi I	11147929	2000
29	Effects of interferon-alpha on peripheral neutrophil counts and serum granulocyte colony-stimulating factor levels in chronic hepatitis C patients. ⁵³ ⁶²	Fukuda A...Ohsawa N	11140884	2000
30	Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. ⁵³ ⁶²	Schuld A...Pollmacher T	10937789	2000
31	Ticlopidine-induced severe agranulocytosis after the placement of coronary artery stent--a case report. ⁵³ ⁶²	Sari R...Buyukberber S	10917583	2000
32	[Do hematopoietic growth factors have a role in the treatment of drug-induced agranulocytosis?]. ⁵³ ⁶²	Andres E...Dufour P	10942973	2000
33	The effect of CVVHD and endotoxin on the oxidative burst, adhesion molecules and distribution in tissues of granulocytes. ⁵³ ⁶²	Toft P...Jorgensen HS	10945396	2000
34	Granulocyte-macrophage colony-stimulating factor (GM-CSF) but not granulocyte colony-stimulating factor (G-CSF) induces plasma membrane expression of proteinase 3 (PR3) on neutrophils in vitro. ⁵³ ⁶²	Hellmich B...Ernst M	10792393	2000
35	[Agranulocytosis in acute hepatitis B in an HIV seropositive patient]. ⁵³ ⁶²	Brazille P...Raguin G	10738502	2000
36	Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis. ⁵³ ⁶²	Wadelius M...Rane A	10739170	2000
37	Analysis of TH1 and TH2 cells by intracellular cytokine detection with flow cytometry in patients with ovarian cancer. ⁵³ ⁶²	Aoki Y...Tanaka K	11014957	2000
38	Treatment of antithyroid drug-induced agranulocytosis by granulocyte colony-stimulating factor: a case of primum non nocere. ⁵³ ⁶²	Hirsch D...Blum I	10560960	1999
39	The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis. ⁵³ ⁶²	Altunbas H...Undar L	10695110	1999
40	Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancer. ⁵³ ⁶²	Scheithauer W...Depisch D	10071282	1999
41	Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. ⁵³ ⁶²	Beauchesne MF...Shalansky SJ	10221368	1999
42	Treatment of drug-induced agranulocytosis with haematopoietic growth factors: a review of the clinical experience. ⁵³ ⁶²	Vial T...Descotes J	18031129	1999
43	Granulocyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis: a prospective study. ⁵³ ⁶²	Fukata S...Sugawara M	10037073	1999
44	Fever or a soar throat after start of antithyroidal drugs? A medical emergency. ⁵³ ⁶²	Roeloffzen WW...Gansevoort RT	9803142	1998
45	A multi-center safety trial of the oral iron chelator deferiprone. ⁵³ ⁶²	Cohen A...Tricta F	9668543	1998
46	Elevated serum granulocyte colony-stimulating factor levels in patients with Graves' disease. ⁵³ ⁶²	Iitaka M...Ito K	9578815	1998
47	Successful treatment of a patient with Graves' disease on hemodialysis complicated by antithyroid drug-induced granulocytopenia and angina pectoris. ⁵³ ⁶²	Miyasaka Y...Inada M	9292952	1997
48	Usefulness of granulocyte count measurement four hours after injection of granulocyte colony-stimulating factor for detecting recovery from antithyroid drug-induced granulocytopenia. ⁵³ ⁶²	Tajiri J...Murakami N	9292945	1997
49	The influence of clozapine treatment on plasma granulocyte colony-stimulating (G-CSF) levels. ⁵³ ⁶²	Pollmacher T...Hinze-Selch D	9271776	1997
50	Recombinant human granulocyte colony-stimulating factor in treatment of methimazole-induced agranulocytosis. ⁵³ ⁶²	Westphal SA	15251798	1997

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Genes for Granulocytopenia

Genes related to Granulocytopenia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CSF3	Colony Stimulating Factor 3	Protein Coding	18.25	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15644577 9292945 18181220 (more) 7679571 15785251 7693069 7525366 10037073 11140884 8927660 7541156 11959056 9028308 7530522 15251798 9017166 10937789 1281122 1698422 7685193 11094146 9292952 7512460 7693988 7525542 7522393 7515127 7523362 7509672 10695110 9578815 7528854 10560960 7504534 7692832 9271776 7516556 1709218 1374635 11496310 11014957 10917583 9815746 9019189 7727054 7533691 7525175 7511003 9503276 8129380 7504155 7687052 1374636 14692133 16595571 11255275 9803142 8983890 17152498 16043267 12661801 12424538 9229817 8985818 8918674 7549901 7526087 7525662 8152201 7507240 7504975 7692002 1702678 20305597 16006735 10792393 10071282 9668543 7485091 7538658 8342541 1690024 20462096 18774664 18031129 12702898 8605273 7540528 7539786 8052932 7681134 1383662 1697455 11903469 7679557 1283811 1380205 1722234 7530591
2	ITGAM	Integrin Subunit Alpha M	Protein Coding	12.31	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8856254 1292337 7490516
3	SELL	Selectin L	Protein Coding	10.63	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10945396 17567268 7490516 (more) 8856254
4	IL3	Interleukin 3	Protein Coding	8.31	Novoseek inferred ⁵³	7528487 10942973 7906401 (more) 8524426 8834013 7687857 7693069 7536476 7543179 9017166 9009076 10221368 8265854 7511003 10605203 14984824 18613811 8338776 7525542 7528854 9130684 7801148 7579485 10738502 12186123 7694163 7543178 7579383 16043267
5	CSF2	Colony Stimulating Factor 2	Protein Coding	7.7	Novoseek inferred ⁵³	8824661 1697455 1556524 (more) 8315450 7727054 7528487 8503246 7538825 8460920 18031129 1639744 7621631 8305835
6	HYOU1	Hypoxia Up-Regulated 1	Protein Coding	7.22	GeneCards inferred via : Disorders (show sections)
7	MPO	Myeloperoxidase	Protein Coding	7.06	Novoseek inferred ⁵³	15538122 17602675 18489081 (more) 9038241 1346986 8385460 11147929
8	NQO2	N-Ribosyldihydronicotinamide:Quinone Reductase 2	Protein Coding	5.25	Novoseek inferred ⁵³	14617031
9	ITGB2	Integrin Subunit Beta 2	Protein Coding	3.69	Novoseek inferred ⁵³	10945396 17567268
10	NAT2	N-Acetyltransferase 2	Protein Coding	2.51	Novoseek inferred ⁵³	10739170

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Variations for Granulocytopenia

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Expression for Granulocytopenia

Search GEO for disease gene expression data for Granulocytopenia.

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Pathways for Granulocytopenia

Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.53	CSF2 CSF3 IL3 ITGAM ITGB2 MPO
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.04	ITGB2 ITGAM IL3 CSF3 CSF2
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.88	ITGB2 ITGAM IL3 CSF3 CSF2
4	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	11.78	SELL ITGB2 ITGAM
5	G-protein signaling_RhoA regulation pathway ²²	11.43	ITGB2 ITGAM IL3
6	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	SELL ITGAM CSF2
7	MSP-RON Signaling ⁶⁴	11.24	ITGB2 ITGAM
8	Interleukin-10 signaling ⁶⁶	11.22	CSF3 CSF2
9	Immune response_Role of integrins in NK cells cytotoxicity ²²	11.18	ITGB2 ITGAM
10	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.16	ITGB2 ITGAM
11	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.16	SELL MPO ITGAM IL3 CSF3 CSF2
12	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ⁶¹	11.1	ITGB2 ITGAM
13	Beta2 integrin cell surface interactions ⁶¹	10.94	ITGB2 ITGAM
14	amb2 Integrin signaling ⁶¹	10.92	ITGB2 ITGAM
15	Cytokines and inflammatory response ⁷⁴	10.59	IL3 CSF3 CSF2
16	G-protein signaling_Rap2B regulation pathway ²²	10.56	ITGB2 ITGAM IL3 CSF3 CSF2
17	Sulfamethoxazole Pathway, Pharmacokinetics ⁶⁰	9.63	NAT2 MPO

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GO Terms for Granulocytopenia

Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle lumen	GO:0071682	9.26	HYOU1 CSF3
2	integrin alphaM-beta2 complex	GO:0034688	8.92	ITGB2 ITGAM

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	microglial cell activation	GO:0001774	9.67	ITGB2 ITGAM
2	positive regulation of superoxide anion generation	GO:0032930	9.62	ITGB2 ITGAM
3	amyloid-beta clearance	GO:0097242	9.56	ITGB2 ITGAM
4	positive regulation of neutrophil degranulation	GO:0043315	9.46	ITGB2 ITGAM
5	positive regulation of prostaglandin-E synthase activity	GO:2000363	9.26	ITGB2 ITGAM
6	negative regulation of dopamine metabolic process	GO:0045963	8.92	ITGB2 ITGAM