Granulocytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: GRN017 MIFTS: 46	Granulocytopenia Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Granulocytopenia

MalaCards integrated aliases for Granulocytopenia:

Name: Granulocytopenia ⁵³

Agranulocytosis ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷³ C0001824

Sources

Summaries for Granulocytopenia

MalaCards based summary : Granulocytopenia, also known as agranulocytosis, is related to acute leukemia and cohen syndrome. An important gene associated with Granulocytopenia is ITGAM (Integrin Subunit Alpha M), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Cisplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, bone and bone marrow, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷⁶ Granulocytes are a category of white blood cells characterized by the presence of granules in their... more...

Sources

Related Diseases for Granulocytopenia

Diseases related to Granulocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)

#	Related Disease	Score	Top Affiliating Genes
1	acute leukemia	32.2	CSF3 IL3 MPO
2	cohen syndrome	30.3	ITGAM SELL
3	leukostasis	30.2	MPO SELL
4	shwartzman phenomenon	29.9	ITGAM TNF
5	vasculitis	29.9	MPO SELL TNF
6	anca-associated vasculitis	29.8	MPO TNF
7	stomatitis	29.7	CSF2 CSF3 TNF
8	neutropenia	29.7	CSF2 CSF3 IL3
9	chronic granulomatous disease	29.6	CSF2 CSF3 MPO
10	aplastic anemia	29.5	CSF2 CSF3 IL3 TNF
11	acute promyelocytic leukemia	29.1	CSF3 IL3 ITGAM ITGB2 MPO
12	granulocytopenia with immunoglobulin abnormality	12.1
13	leukemia	10.3
14	thrombocytopenia	10.3
15	boutonneuse fever	10.2	CP SELL
16	retinitis pigmentosa 60	10.2	SELL TNF
17	penicilliosis	10.2	ITGAM TNF
18	engraftment syndrome	10.2	CSF2 CSF3
19	1,4-phenylenediamine allergic contact dermatitis	10.1	NAT2 TNF
20	chronic pulmonary heart disease	10.1	CP TNF
21	autoimmune inner ear disease	10.1	MPO TNF
22	chronic monocytic leukemia	10.1	ITGAM MPO
23	arthus reaction	10.1	SELL TNF
24	seborrheic infantile dermatitis	10.1	CSF2 IL3
25	burns	10.1	CSF2 TNF
26	microscopic polyangiitis	10.1	MPO TNF
27	trichosporonosis	10.1	CSF2 CSF3 TNF
28	stachybotrys chartarum	10.1	IL3 TNF
29	meconium aspiration syndrome	10.1	CSF2 TNF
30	marburg hemorrhagic fever	10.1	NQO2 TNF
31	deficiency anemia	10.1	CP CSF3 IL3
32	monocytic leukemia	10.1	CSF2 ITGAM TNF
33	behcet syndrome	10.1	CP SELL TNF
34	arthritis	10.1
35	felty syndrome	10.1	CSF2 CSF3 IL3
36	cyclic neutropenia	10.1	CSF2 CSF3 IL3
37	anemia of prematurity	10.0	CSF2 CSF3 IL3
38	pleurisy	10.0	MPO SELL TNF
39	peritonitis	10.0	ITGAM MPO TNF
40	pancytopenia	10.0	CSF2 CSF3 IL3
41	severe congenital neutropenia	10.0	CSF2 CSF3 IL3
42	proteasome-associated autoinflammatory syndrome 1	10.0	MPO SELL TNF
43	toxic oil syndrome	10.0	CP NAT2
44	cytomegalovirus retinitis	10.0	CSF2 TNF
45	pneumonia	10.0	CSF3 MPO TNF
46	sarcoidosis 1	10.0	CSF2 IL3 TNF
47	lymphoma	10.0
48	ileitis	10.0	CSF2 MPO TNF
49	essential thrombocythemia	10.0	IL3 ITGAM MPO
50	leukocyte adhesion deficiency, type i	10.0	ITGAM ITGB2 SELL

Graphical network of the top 20 diseases related to Granulocytopenia:

Sources

Symptoms & Phenotypes for Granulocytopenia

MGI Mouse Phenotypes related to Granulocytopenia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.61	CP CSF2 CSF3 ITGAM ITGB2 MPO
2	immune system	MP:0005387	9.32	CP CSF2 CSF3 ITGAM ITGB2 LAP3

Sources

Drugs & Therapeutics for Granulocytopenia

Drugs for Granulocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 716)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cisplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

15663-27-1

2767 441203 84093

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

6055-19-2, 50-18-0

2907

Prednisone

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

53-03-2

5865

Vincristine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

57-22-7, 2068-78-2

5978

Gemcitabine

Approved

Phase 4,Phase 2,Phase 3,Phase 1

95058-81-4

60750

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

1177-87-3

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1

50-02-2

5743

Etoposide

Approved

Phase 4,Phase 3,Phase 2,Phase 1

33419-42-0

36462

Methotrexate

Approved

Phase 4,Phase 2,Phase 3,Phase 1

59-05-2, 1959-05-2

126941

Doxorubicin

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1

23214-92-8

31703

Oxaliplatin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

61825-94-3

43805 6857599 5310940 9887054

Epirubicin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

56420-45-2

41867

Cytarabine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

147-94-4

6253

Cilastatin

Approved, Investigational

Phase 4,Not Applicable

82009-34-5

6435415 5280454

Meropenem

Approved, Investigational

Phase 4,Phase 2

119478-56-7

64778 441130

Imipenem

Approved

Phase 4,Not Applicable

74431-23-5, 64221-86-9

104838

Triamcinolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

124-94-7

31307

Lenograstim

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

135968-09-1

Tazobactam

Approved

Phase 4,Phase 2,Not Applicable

89786-04-9

123630

Vancomycin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

1404-90-6

14969 441141

Piperacillin

Approved

Phase 4,Phase 2,Not Applicable

66258-76-2

43672

Ceftazidime

Approved

Phase 4,Phase 3,Phase 2

78439-06-2, 72558-82-8

5481173

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

22916-47-8

4189

Micafungin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

235114-32-6

3081921 477468

Ciprofloxacin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

85721-33-1

2764

Trimethoprim

Approved, Vet_approved

Phase 4,Phase 2

738-70-5

5578

Sulfamethoxazole

Approved

Phase 4,Phase 2

723-46-6

5329

Iron

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

7439-89-6

23925

Omeprazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2

73590-58-6

4594

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Docetaxel

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

114977-28-5

148124

leucovorin

Approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

58-05-9

6006 143

Voriconazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

137234-62-9

71616

Carboplatin

Approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

41575-94-4

10339178 38904 498142

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

83-43-2

6741

Prednisolone

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

50-24-8

5755

Prednisolone phosphate

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1

302-25-0

Methylprednisolone hemisuccinate

Approved

Phase 4,Phase 2,Phase 3,Phase 1

2921-57-5

Fluorouracil

Approved

Phase 4,Phase 3,Phase 2,Phase 1

51-21-8

3385

Paclitaxel

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

33069-62-4

36314

Idarubicin

Approved

Phase 4,Phase 3,Phase 2,Phase 1

58957-92-9

42890

Irinotecan

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

100286-90-6, 97682-44-5

60838

Capecitabine

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

154361-50-9

60953

Sirolimus

Approved, Investigational

Phase 4,Phase 2,Phase 1

53123-88-9

46835353 6436030 5284616

Everolimus

Approved

Phase 4,Phase 2,Phase 1

159351-69-6

6442177

Valganciclovir

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

175865-60-8

64147

Ganciclovir

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

82410-32-0

3454

rituximab

Approved

Phase 4,Phase 2,Phase 3,Phase 1

174722-31-7

10201696

Vinblastine

Approved

Phase 4,Phase 2,Phase 3,Phase 1

865-21-4

241903 13342

Levofloxacin

Approved, Investigational

Phase 4,Phase 3,Not Applicable

100986-85-4

149096

Interventional clinical trials:

(show top 50) (show all 1468)

#	Name	Status	NCT ID	Phase	Drugs
1	PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia	Unknown status	NCT02996617	Phase 4	rhG-CSF regimen;Pegylated rhG-CSF regimen
2	Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO	Unknown status	NCT02149329	Phase 4	Discontinuation of imipenem-cilastatin or meropenem
3	Prevention of Neutropenia After Using G-CSF With TAC Chemotherapy	Unknown status	NCT01571518	Phase 4	late leukostim;early leukostim
4	Short vs Prolonged Antibiotic Treatment for Hospitalized Hemato-oncology Patients With Febrile Neutropenia	Unknown status	NCT02463747	Phase 4	Piperacillin/tazobactam;Ceftazidim;Meropenem;Vancomycin
5	Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer	Unknown status	NCT00030758	Phase 4
6	The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy	Unknown status	NCT02905916	Phase 4	PEG-rhG-CSF
7	Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation	Unknown status	NCT01135589	Phase 4	Micafungin
8	Blood Draw Validation for Ciprofloxacin Pharmacokinetic Research in Pediatric Cancer Patients	Unknown status	NCT02967341	Phase 4
9	Effect and Safety of Oral Vancomycin in Primary Sclerosing Cholangitis Patients	Unknown status	NCT02605213	Phase 4	Vancomycin;Placebo
10	Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda	Unknown status	NCT00674921	Phase 4	cotrimoxazole;Placebo
11	Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC	Unknown status	NCT01795794	Phase 4	omeprazole
12	THE USE OF N-ACETYLCYSTEINE ATTENUATING CISPLATIN-INDUCED TOXICITIES BY OXIDATIVE STRESS	Unknown status	NCT02241876	Phase 4	N-acetylcysteine
13	Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia	Completed	NCT01581333	Phase 4	Empirical antimicrobial treatment discontinuation;Standard empirical antimicrobial treatment discontinuation
14	Comparison of the Pharmacodynamics of Imipenem in Patients With Febrile Neutropenia	Completed	NCT02213783	Phase 4	Imipenem;Imipenem
15	A Clinical Trial of Patients With Solid Tumours Receiving Granulocyte Colony Stimulating Factor as Primary Prophylaxis for Chemotherapy-induced Neutropenia, in a Docetaxel Based Regimen	Completed	NCT01107756	Phase 4	LENOGRASTIM (GRANOGYTE 34)
16	PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy to Prevent Neutropenia	Completed	NCT02805205	Phase 4	PEG-rhG-CSF
17	Study of Cabazitaxel Combined With Prednisone and Prophylaxis of Neutropenia Complications in the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer	Completed	NCT01649635	Phase 4	CABAZITAXEL (XRP6258);Prednisone;Ciprofloxacin;G-CSF (Granulocyte colony-stimulating factor)
18	REaCT Integrated Consent Model to Compare Two Standard of Care Regimens	Completed	NCT02173262	Phase 4	G-CSF;Ciprofloxacin
19	Posaconazole Versus Micafungin for Prophylaxis Against Invasive Fungal Infections During Neutropenia in Patients Undergoing Chemotherapy for Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia or Myelodysplastic Syndrome	Completed	NCT01200355	Phase 4	micafungin;posaconazole
20	Pharmacokinetic/Pharmacodynamic Study of Doripenem in Febrile Neutropenic Patients	Completed	NCT01401010	Phase 4	Doripenem;doripenem
21	A Study of Primary Prophylaxis With Neulasta (Pegfilgrastim) Versus Secondary Prophylaxis After Chemotherapy in Elderly Subjects (>/= 65 Years Old) With Cancer	Completed	NCT00277160	Phase 4	Neulasta (pegfilgrastim)
22	FIRST - Study of Pegfilgrastim Administered in the First and Subsequent Cycles of Myelosuppressive Chemotherapy	Completed	NCT00125723	Phase 4
23	PEG-rhG-CSF in Patients With Breast Cancer Receiving Chemotherapy	Completed	NCT02805153	Phase 4	PEG-rhG-CSF;rhG-CSF
24	Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy	Completed	NCT00115206	Phase 4	Neulasta® (pegfilgrastim)
25	Comparison of Teicoplanin and Vancomycin in Initial Empirical Antibiotic Regimen for Febrile Neutropenic Patients	Completed	NCT00454272	Phase 4	Teicoplanin;Vancomycin
26	Safety of Cotrimoxazole in HIV- and HAART-exposed Infants	Completed	NCT01086878	Phase 4	cotrimoxazole
27	The Tobramycin Study	Completed	NCT00257790	Phase 4	Tobramycin once a day
28	Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections	Completed	NCT00709358	Phase 4
29	Antifungal Use in Oncohematological Neutropenic Patients	Completed	NCT00386802	Phase 4	Antifungal drug. VORICONAZOL. (VFEND®)
30	Steady-State Comparative Bioavailability Study in Prophylaxis Patients of Lozanoc® 50 mg With Sporanox® 100 mg	Completed	NCT02621905	Phase 4	Sporanox;Lozanoc
31	An Expanded Access Program of Pegfilgrastim (Neulastim) in Participants With Non-Hodgkin's Lymphoma (NHL)	Completed	NCT02782845	Phase 4	Chemotherapy;Immunochemotherapy;Pegfilgrastim
32	Safety Study of Adjuvant Docetaxel-Carboplatin Treatment for Resected Lung Cancer	Completed	NCT00883675	Phase 4	Docetaxel-Carboplatin
33	Value of the LightCycler® SeptiFast Test MGRADE for the Pathogen Detection in Neutropenic Hematological Patients	Completed	NCT01114165	Phase 4
34	Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)	Completed	NCT00686543	Phase 4	Posaconazole
35	Combination of Cabazitaxel With Prednisolone With Primary Prophylaxis With PEG-G-CSF in Treatment of Patients With Prostate Cancer	Completed	NCT02441894	Phase 4	CABAZITAXEL XRP6258;PEG-G-CSF;Prednisolone;Dexchlorpheniramine or Diphenhydramine;Ranitidine;Metoclopramide, Granisetron, or Ondansetron;Dexamethasone
36	PEG-rhG-CSF in Patients With Malignant Solid Tumors Receiving Chemotherapy	Completed	NCT02805166	Phase 4	PEG-rhG-CSF
37	PEG-rhG-CSF in Patients With Lymphoma Receiving Chemotherapy	Completed	NCT02805218	Phase 4	PEG-rhG-CSF
38	Safety of Orectalip® (Oxaliplatin) as Adjuvant Treatment for High-risk Stage-Ⅱ Colorectal Cancer	Completed	NCT02284529	Phase 4	Orectalip
39	Doxorubicin Pharmacokinetics and Response in Non Hodgkin's Lymphoma	Completed	NCT00969462	Phase 4	Doxorubicin
40	Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly	Completed	NCT02151149	Phase 4	nab-paclitaxel;Carboplatin
41	Efficacy of Itraconazole as Secondary Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplantation or Chemotherapy With Prior Invasive Fungal Infection	Completed	NCT01198236	Phase 4	Itraconazole
42	Antifugal Effect of Recombinant Human Granulocyte-macrophage Stimulating Factor (rhGM-CSF) in Patients Post Allo-HSCT	Completed	NCT01232504	Phase 4	rhGM-CSF group;rhG-CSF+rhGM-CSF group;rhG-CSF group
43	The Efficacy and Safety Study of Fuganlin Oral Liquid in Children With Influenza (Acute Upper Respiratory Infection)	Completed	NCT02622659	Phase 4	Fuganlin Oral Liquid;Xiaoer Jiebiao Oral Liquid
44	Oral Zinc Therapy for the Prevention of Mucositis	Completed	NCT00449592	Phase 4	Zinc;Placebo
45	SMD_FLAG-IDA_98: FLAG-IDA in Induction Treatment of High Risk Myelodysplastic Syndromes or Secondary Acute Myeloblastic Leukemia	Completed	NCT00487448	Phase 4	Fludarabine;Cytarabine;G-CSF;Idarubicin
46	Phase II Trial Evaluating Irinotecan and Capecitabine Relapsed/Refractory Upper GI Tumours	Completed	NCT00220168	Phase 4	Irinotecan, Capecitabine
47	Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporine Versus an Immunosuppressive Regimen With Mycophenolic Acid and Standard Dose of Cyclosporine A	Completed	NCT02328963	Phase 4	Everolimus;mycophenolic acid
48	VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel	Completed	NCT01684813	Phase 4	Prasugrel.;Clopidogrel
49	Study on Bone Marrow Morphology in Adults Receiving Romiplostim for Treatment of Thrombocytopenia Associated With Immune Thrombocytopenia Purpura (ITP)	Completed	NCT00907478	Phase 4
50	A Study of The Relationship Between Drop in Hemoglobin and Sustained Virological Response in Patients With Chronic Hepatitis C Treated With Copegus (Ribavirin) and Pegasys (Peginterferon Alfa-2a)	Completed	NCT01585324	Phase 4	peginterferon alfa-2a [Pegasys];ribavirin [Copegus]

Search NIH Clinical Center for Granulocytopenia

Sources

Genetic Tests for Granulocytopenia

Sources

Anatomical Context for Granulocytopenia

MalaCards organs/tissues related to Granulocytopenia:

⁴¹

Neutrophil, Bone, Bone Marrow, Liver, T Cells, Myeloid, Breast

Sources

Publications for Granulocytopenia

Articles related to Granulocytopenia:

(show top 50) (show all 1178)

#	Title	Authors	Year
1	50 Years Ago in The Journal of Pediatrics: Familial Granulocytopenia and Associated Immunoglobulin Abnormality: Report of 3 Cases in Young Brothers. ( 29478506 )	Heikamp E....Forbes L.	2018
2	Clozapine-induced agranulocytosis/granulocytopenia: mechanisms and monitoring. ( 28984748 )		2018
3	Clozapine-Associated Cytomegalovirus Colitis and Related Critical Illness in a Patient With Neither Neutropenia Nor Agranulocytosis. ( 30280578 )	Chu CW...Liang CS	2018
4	Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters. ( 29789870 )	Bielen L...Bo?ina N	2018
5	Agranulocytosis and Good Syndrome in Patient with Thymoma-The Role of Immunosuppressive Treatment after Thymectomy. ( 30166018 )	Markovic O...Marisavljevic D	2018
6	Granulocytopenia. ( 30193521 )	?erm?k J	2018
7	A case of antithyroid drug-induced agranulocytosis from a second antithyroid drugs (ATD) administration in a relapsed Graves' disease patient who was tolerant to the first ATD treatment. ( 30214745 )	Kim H...Ha J	2018
8	Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature. ( 29552362 )	Garla V...Abdul Salim S	2018
9	Pembrolizumab-induced agranulocytosis in a pulmonary pleomorphic carcinoma patient who developed interstitial lung disease and ocular myasthenia gravis. ( 30364514 )	Tozuka T...Gemma A	2018
10	Agranulocytosis Associated with Waldenström Macroglobulinemia. ( 30114687 )	Vaxman I...Lahav M	2018
11	Mask Off? Lithium Augmentation for Clozapine Rechallenge After Neutropenia or Agranulocytosis: Discontinuation Might Be Risky. ( 30549484 )	Boazak M...Cotes RO	2018
12	Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and Agranulocytosis. ( 30319405 )	Numata S...Hashimoto R	2018
13	Agranulocytosis associated with voriconazole-induced hypersensitivity syndrome. ( 29168223 )	Kaneko Y...Hashizume H	2018
14	Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. ( 30328081 )	Aslan N...Ozden O	2018
15	Sulfasalazine-Induced Agranulocytosis Is Associated With the Human Leukocyte Antigen Locus. ( 28762467 )	Wadelius M...EuDAC	2018
16	Thiamazole-Induced Agranulocytosis Leading to Abscessus Pneumonia-Rare, But Challenging. ( 29203051 )	Lazovic B...Zugic V	2018
17	Decreased miR-17-92 cluster expression level in serum and granulocytes preceding onset of antithyroid drug-induced agranulocytosis. ( 29255972 )	Yang J...Wen G	2018
18	Safety of dipyrone (metamizole) in children-What's the risk of agranulocytosis? ( 29345086 )	Ziesenitz VC...van den Anker JN	2018
19	Acute agranulocytosis after oral administration of dabigatran: a rare case report and a short review of literature. ( 29404875 )	Fasullo S...Maringhini G	2018
20	Reply to Ziesenitz, Victoria; Erb Thomas; Trachsel, Daniel; van den Anker Johannes, regarding their comment "Safety of dipryone (metamizole) in children-what's the risk of agranulocytosis?" ( 29436141 )	de Leeuw TG...de Wildt SN	2018
21	Agranulocytosis Associated with Topiramate: A Case Report and Review of Published Cases. ( 29545956 )	Lohani S...Donato A	2018
22	Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor. ( 29560017 )	Kubota Y...Toh Yoon EW	2018
23	A Case of Levamisole-Induced Agranulocytosis. ( 29607229 )	Kassim T...Gbadamosi-Akindele M	2018
24	Minimization of the perianal infection rate of hematological malignancies with agranulocytosis by quality control circle activity and patient-hospital-student win-win concept. ( 29633650 )	Jiang Q...Li W	2018
25	Transient immune-mediated agranulocytosis following Mycoplasma pneumoniae infection. ( 29669774 )	Barge L...Weber N	2018
26	Recurrent Levamisole-Induced Agranulocytosis Complicated by Bowel Ischemia in a Cocaine User. ( 29853712 )	Khan MS...Yoon Y	2018
27	Clozapine pharmacogenomics: a review of efficacy, pharmacokinetics, and agranulocytosis. ( 29985178 )	Li KJ...DeLisi LE	2018
28	Erratum to "Severe Drug-Induced Agranulocytosis Successfully Treated with Recombinant Human Granulocyte Colony-Stimulating Factor". ( 30034475 )	Kubota Y...Toh Yoon EW	2018
29	Zero Eosinophil Count as a Predictor of Clozapine-Associated Late-Onset Agranulocytosis: A Case Report. ( 30113930 )	Yang HN...Liang CS	2018
30	Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients. ( 30123266 )	Thao MP...Minh DD	2018
31	Agranulocytosis Induced by Vancomycin. Case Report and Literature Review. ( 30174327 )	di Fonzo H...Rueda D	2018
32	Metamizole (dipyrone)-induced agranulocytosis: Does the risk vary according to ethnicity? ( 30311250 )	Shah RR	2018
33	Transethnic Replication Study to Assess the Association Between Clozapine-Induced Agranulocytosis/Granulocytopenia and Genes at 12p12.2 in a Japanese Population. ( 28161127 )		2017
34	Myeloprotective effects of C-type natriuretic peptide on cisplatin-induced bone marrow granulocytopenia in mice. ( 28101584 )	Zenitani M...Kangawa K	2017
35	Graves' disease in a 3 year-old patient with agranulocytosis due to anti-thyroid drugs: Radioiodine ablation therapy as an effective alternative. ( 28392335 )	Espinosa-Mu?oz E...Puentes-Zarzuela C	2017
36	Graves' Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy. ( 29181135 )	Candoni A...Fanin R	2017
37	Clozapine-Associated Neutropenia and Agranulocytosis. ( 29040154 )	Andres E...Mourot-Cottet R	2017
38	History and outcome of febrile neutropenia related to non-chemotherapy drugs: A retrospective study of the Strasbourg's agranulocytosis cohort. ( 28823525 )	Andr?s E...Gottenberg JE	2017
39	Agranulocytosis occurrence following recent acute infectious mononucleosis. ( 27912922 )	Massoll AF...Betten DP	2017
40	Thyroidectomy for the treatment of Graves' thyrotoxicosis in thioamide-induced agranulocytosis and sepsis. ( 28924483 )	Knight CL...Kotowicz M	2017
41	Methamphetamine Use With Subsequent Thyrotoxicosis/Thyroid Storm, Agranulocytosis, and Modified Total Thyroidectomy: A Case Report. ( 29200896 )	Viswanath O...Headley DB	2017
42	Febuxostat-induced agranulocytosis in an end-stage renal disease patient: A case report. ( 28079821 )	Poh XE...Pei SN	2017
43	Incidence and risk estimate of drug-induced agranulocytosis in Hong Kong Chinese. A population-based case-control study. ( 28083886 )	Sing CW...Cheung CL	2017
44	Antithyroid Drug-Induced Agranulocytosis: State of the Art on Diagnosis and Management. ( 28105610 )	Vicente N...Carrilho F	2017
45	Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center. ( 28236218 )	He Y...Shi B	2017
46	Fever, rash and agranulocytosis. ( 28270401 )	Khan U...Hadid T	2017
47	Dapsone-induced agranulocytosis-possible involvement of low-activity N-acetyltransferase 2. ( 28322460 )	Poto?njak I...Bo?ina N	2017
48	More than 25 years of genetic studies of clozapine-induced agranulocytosis. ( 28418011 )	de With SAJ...Ophoff RA	2017
49	Clozapine-Associated Agranulocytosis Treatment With Granulocyte Colony-Stimulating Factor/Granulocyte-Macrophage Colony-Stimulating Factor: A Systematic Review. ( 28437295 )	Lally J...MacCabe JH	2017
50	Agranulocytosis - Sequelae of Chronic Cocaine Use: Case Series and Literature Review. ( 28589070 )	Srivastava R...Salzman D	2017

Sources

Genes for Granulocytopenia

Genes related to Granulocytopenia (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	ITGAM	Integrin Subunit Alpha M	Protein Coding	22.3	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	8856254 1292337 7490516
2	SELL	Selectin L	Protein Coding	20.62	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	10945396 17567268 7490516 (more) 8856254
3	IL3	Interleukin 3	Protein Coding	18.31	Novoseek inferred ⁵⁵	7528487 10942973 7906401 (more) 8524426 8834013 7687857 7693069 7536476 7543179 9017166 9009076 10221368 8265854 7511003 10605203 14984824 18613811 8338776 7525542 7528854 9130684 7801148 7579485 10738502 12186123 7694163 7543178 7579383 16043267
4	CSF3	Colony Stimulating Factor 3	Protein Coding	18.24	Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15644577 9292945 18181220 (more) 7679571 15785251 7693069 7525366 10037073 11140884 8927660 7541156 11959056 9028308 7530522 15251798 9017166 10937789 1281122 1698422 7685193 11094146 9292952 7512460 7693988 7525542 7522393 7515127 7523362 7509672 10695110 9578815 7528854 10560960 7504534 7692832 9271776 7516556 1709218 1374635 11496310 11014957 10917583 9815746 9019189 7727054 7533691 7525175 7511003 9503276 8129380 7504155 7687052 1374636 14692133 16595571 11255275 9803142 8983890 17152498 16043267 12661801 12424538 9229817 8985818 8918674 7549901 7526087 7525662 8152201 7507240 7504975 7692002 1702678 20305597 16006735 10792393 10071282 9668543 7485091 7538658 8342541 1690024 20462096 18774664 18031129 12702898 8605273 7540528 7539786 8052932 7681134 1383662 1697455 11903469 7679557 1283811 1380205 1722234 7530591
5	CSF2	Colony Stimulating Factor 2	Protein Coding	17.7	Novoseek inferred ⁵⁵	8824661 1697455 1556524 (more) 8315450 7727054 7528487 8503246 7538825 8460920 18031129 1639744 7621631 8305835
6	MPO	Myeloperoxidase	Protein Coding	17.06	Novoseek inferred ⁵⁵	15538122 17602675 18489081 (more) 9038241 1346986 8385460 11147929
7	CPQ	Carboxypeptidase Q	Protein Coding	16.68	GeneCards inferred via : Publications (show sections)
8	CP	Ceruloplasmin	Protein Coding	16.68	GeneCards inferred via : Publications (show sections)
9	TNF	Tumor Necrosis Factor	Protein Coding	16.68	GeneCards inferred via : Publications (show sections)
10	NQO2	N-Ribosyldihydronicotinamide:Quinone Reductase 2	Protein Coding	15.25	Novoseek inferred ⁵⁵	14617031
11	ITGB2	Integrin Subunit Beta 2	Protein Coding	13.69	Novoseek inferred ⁵⁵	10945396 17567268
12	NAT2	N-Acetyltransferase 2	Protein Coding	12.51	Novoseek inferred ⁵⁵	10739170
13	LAP3	Leucine Aminopeptidase 3	Protein Coding	6.68	GeneCards inferred via : Publications (show sections)
14	HLA-S	Major Histocompatibility Complex, Class I, S (Pseudogene)	Pseudogene	6.68	GeneCards inferred via : Publications (show sections)

Sources

Variations for Granulocytopenia

Sources

Expression for Granulocytopenia

Search GEO for disease gene expression data for Granulocytopenia.

Sources

Pathways for Granulocytopenia

Pathways related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.25	CSF2 CSF3 IL3 ITGAM ITGB2 TNF
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.2	CSF2 CSF3 IL3 ITGAM ITGB2 TNF
3	NF-kappaB Signaling ⁴	12.41	IL3 ITGB2 MPO TNF
4	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁷	12.37	CSF2 IL3 ITGB2 TNF
5	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.09	ITGAM ITGB2 TNF
6	Transcriptional misregulation in cancer ³⁷	12.09	CSF2 IL3 ITGAM MPO
7	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	12.07	ITGAM ITGB2 SELL
8	Tuberculosis ³⁷	12.07	ITGAM ITGB2 TNF
9	Phagosome ³⁷	11.99	ITGAM ITGB2 MPO
10	Cell adhesion molecules (CAMs) ³⁷	11.96	ITGAM ITGB2 SELL
11	Interleukin-4 and 13 signaling ⁶⁶	11.84	ITGAM ITGB2 TNF
12	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	11.83	CSF2 ITGAM ITGB2 TNF
13	Rheumatoid arthritis ³⁷	11.71	CSF2 ITGB2 TNF
14	Amoebiasis ³⁷	11.65	CSF2 ITGAM ITGB2 TNF
15	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.63	CSF2 IL3 TNF
16	Pertussis ³⁷	11.62	ITGAM ITGB2 TNF
17	Lung fibrosis ¹	11.53	CSF2 CSF3 TNF
18	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.49	CSF2 ITGAM SELL TNF
19	Legionellosis ³⁷	11.46	ITGAM ITGB2 TNF
20	Interleukin-10 signaling ⁶⁶	11.38	CSF2 CSF3 TNF
21	Malaria ³⁷	11.36	CSF3 ITGB2 TNF
22	Hematopoietic cell lineage ³⁷	11.34	CSF2 CSF3 IL3 ITGAM TNF
23	Hematopoietic Stem Cell Differentiation ¹	11.33	CSF2 CSF3 IL3
24	MSP-RON Signaling ⁶⁴	11.31	ITGAM ITGB2 TNF
25	amb2 Integrin signaling ¹	11.24	ITGAM ITGB2 MPO TNF
26	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.23	CSF2 CSF3 IL3 ITGAM MPO SELL
27	G-protein signaling_RhoB regulation pathway ²²	11.07	CSF2 CSF3 IL3 TNF
28	Cytokines and Inflammatory Response ¹	10.92	CSF2 CSF3 IL3 TNF
29	LDL Oxidation in Atherogenesis ⁶⁴	10.82	MPO TNF
30	G-protein signaling_Rap2B regulation pathway ²²	10.78	CSF2 CSF3 IL3 ITGAM ITGB2 TNF

Sources

GO Terms for Granulocytopenia

Cellular components related to Granulocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.91	CP CPQ CSF2 CSF3 IL3 MPO
2	extracellular exosome	GO:0070062	9.8	CP CPQ ITGAM ITGB2 LAP3 MPO
3	extracellular space	GO:0005615	9.56	CP CPQ CSF2 CSF3 IL3 ITGAM
4	external side of plasma membrane	GO:0009897	9.46	ITGAM ITGB2 SELL TNF
5	integrin complex	GO:0008305	9.4	ITGAM ITGB2
6	plasma membrane raft	GO:0044853	9.32	ITGAM ITGB2
7	integrin alphaM-beta2 complex	GO:0034688	8.62	ITGAM ITGB2

Biological processes related to Granulocytopenia according to GeneCards Suite gene sharing:

(show all 20)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.89	CSF2 CSF3 IL3 TNF
2	neutrophil degranulation	GO:0043312	9.88	ITGAM ITGB2 MPO SELL
3	regulation of signaling receptor activity	GO:0010469	9.86	CSF2 CSF3 IL3 TNF
4	cellular response to lipopolysaccharide	GO:0071222	9.74	CSF2 CSF3 TNF
5	leukocyte migration	GO:0050900	9.71	ITGAM ITGB2 SELL TNF
6	positive regulation of protein targeting to membrane	GO:0090314	9.58	ITGAM ITGB2
7	leukocyte tethering or rolling	GO:0050901	9.55	SELL TNF
8	toll-like receptor 4 signaling pathway	GO:0034142	9.54	ITGAM ITGB2
9	positive regulation of superoxide anion generation	GO:0032930	9.52	ITGAM ITGB2
10	negative regulation of growth of symbiont in host	GO:0044130	9.51	MPO TNF
11	amyloid-beta clearance	GO:0097242	9.49	ITGAM ITGB2
12	cell-cell adhesion via plasma-membrane adhesion molecules	GO:0098742	9.48	ITGAM ITGB2
13	positive regulation of podosome assembly	GO:0071803	9.46	CSF2 TNF
14	positive regulation of microglial cell activation	GO:1903980	9.43	ITGAM ITGB2
15	cellular extravasation	GO:0045123	9.37	ITGB2 TNF
16	negative regulation of dopamine metabolic process	GO:0045963	9.32	ITGAM ITGB2
17	positive regulation of neutrophil degranulation	GO:0043315	9.26	ITGAM ITGB2
18	positive regulation of prostaglandin-E synthase activity	GO:2000363	9.16	ITGAM ITGB2
19	microglial cell activation	GO:0001774	9.13	ITGAM ITGB2 TNF
20	cytokine-mediated signaling pathway	GO:0019221	9.1	CSF2 CSF3 IL3 ITGAM ITGB2 TNF

Molecular functions related to Granulocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.33	CSF2 CSF3 IL3
2	cytokine activity	GO:0005125	9.26	CSF2 CSF3 IL3 TNF
3	complement component C3b binding	GO:0001851	8.62	ITGAM ITGB2

Sources

Sources for Granulocytopenia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia