MCID: GRN007
MIFTS: 40

Granuloma Annulare

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Granuloma Annulare

MalaCards integrated aliases for Granuloma Annulare:

Name: Granuloma Annulare 38 12 76 53 55 44 15 73
Granulome Annulare 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3777
ICD10 33 L92.0
MeSH 44 D016460
NCIt 50 C3470
UMLS 73 C0085074

Summaries for Granuloma Annulare

NIH Rare Diseases : 53 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. The most commonly affected areas are the forearms, hands and feet. The lesions associated with granuloma annulare usually resolve without treatment. Strong steroids (applied as a cream or injection) are sometimes used to clear the rash more quickly. Most symptoms will disappear within 2 years (even without treatment), but recurrence is common. The underlying cause of granuloma annulare is unknown.

MalaCards based summary : Granuloma Annulare, also known as granulome annulare, is related to necrobiosis lipoidica and multicentric reticulohistiocytosis. An important gene associated with Granuloma Annulare is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways is Interleukin-4 and 13 signaling. The drugs Levofloxacin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and bone, and related phenotype is respiratory system.

Wikipedia : 76 Granuloma annulare is a fairly rare, chronic skin condition which presents as reddish bumps on the skin... more...

Related Diseases for Granuloma Annulare

Diseases related to Granuloma Annulare via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 necrobiosis lipoidica 30.9 GLI1 TNFRSF1B
2 multicentric reticulohistiocytosis 30.1 F13A1 VIM
3 fibrous histiocytoma 29.3 F13A1 VIM
4 angiolipoma 10.2 F13A1 VIM
5 diabetes mellitus 10.2
6 lymphoma 10.2
7 herpes zoster 10.2
8 fibrous meningioma 10.2 F13A1 VIM
9 hepatitis 10.1
10 thyroiditis 10.1
11 juvenile xanthogranuloma 10.1 F13A1 VIM
12 mycosis fungoides 10.1
13 cutaneous fibrous histiocytoma 10.1 F13A1 VIM
14 leukemia 10.1
15 dermatitis 10.1
16 acquired immunodeficiency syndrome 10.1
17 uveitis 10.0
18 hemangiopericytoma, malignant 10.0 F13A1 VIM
19 hepatitis b 10.0
20 lichen sclerosus 10.0
21 mid-dermal elastolysis 10.0
22 malignant fibroxanthoma 10.0 F13A1 VIM
23 hepatitis c virus 9.9
24 myelodysplastic syndrome 9.9
25 b-cell lymphomas 9.9
26 sarcoma 9.9
27 hepatitis c 9.9
28 adenocarcinoma 9.9
29 syphilis 9.9
30 scabies 9.9
31 hepatocellular carcinoma 9.8
32 aging 9.8
33 erythema multiforme 9.8
34 skin sarcoidosis 9.8
35 hyperparathyroidism 9.8
36 hypothyroidism 9.8
37 contact dermatitis 9.8
38 histiocytosis 9.8
39 secondary syphilis 9.8
40 granulomatous dermatitis 9.8
41 angiokeratoma 9.8
42 epithelioid sarcoma 9.8
43 lymphosarcoma 9.8
44 lupus erythematosus 9.8
45 lichen planus 9.8
46 anterior uveitis 9.8
47 rosai-dorfman disease 9.8
48 scleromyxedema 9.8
49 leukemia, chronic lymphocytic 2 9.7
50 carpal tunnel syndrome 9.7

Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to Granuloma Annulare

Symptoms & Phenotypes for Granuloma Annulare

MGI Mouse Phenotypes related to Granuloma Annulare:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 F13A1 GLI1 STAB1 TNFRSF1B VIM

Drugs & Therapeutics for Granuloma Annulare

Drugs for Granuloma Annulare (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational 100986-85-4 149096
2
Minocycline Approved, Investigational 10118-90-8 5281021
3
Ofloxacin Approved 82419-36-1 4583
4
Rifampicin Approved 13292-46-1 5458213 5381226
5 Anti-Bacterial Agents
6 Antibiotics, Antitubercular
7 Anti-Infective Agents
8 Antitubercular Agents
9 Cytochrome P-450 CYP1A2 Inhibitors
10 Cytochrome P-450 CYP3A Inducers
11 Cytochrome P-450 Enzyme Inhibitors
12 Nucleic Acid Synthesis Inhibitors
13 Renal Agents
14 Topoisomerase Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
2 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
3 Proteomic Analysis of Sweat in Cutaneous Conditions Recruiting NCT02768090 Not Applicable
4 UVA1 Light for Scleroderma and Similar Conditions Terminated NCT00476697 Not Applicable

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: granuloma annulare

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

MalaCards organs/tissues related to Granuloma Annulare:

41
Skin, Thyroid, Bone, B Cells, T Cells, Neutrophil, Testes

Publications for Granuloma Annulare

Articles related to Granuloma Annulare:

(show top 50) (show all 621)
# Title Authors Year
1
Pseudolymphomatous Granuloma Annulare: A Little-Known Variant. ( 29861038 )
2018
2
Granuloma Annulare-Like Granulomatous Reaction to Red Tattoo Pigment. ( 29658308 )
2018
3
Disseminated interstitial granuloma annulare associated with hepatocellular carcinoma. ( 29774572 )
2018
4
Granuloma Annulare in the Setting of Secukinumab. ( 29805815 )
2018
5
Subcutaneous granuloma annulare involving the scalp. ( 29205476 )
2018
6
Malignancy-associated generalized perforating granuloma annulare. ( 29318643 )
2018
7
Methotrexate treatment of generalized granuloma annulare: a retrospective case series. ( 29488435 )
2018
8
Acute-onset, painful acral granuloma annulare with unusual microcalcification. ( 29672826 )
2018
9
Usefulness of ultrasonography in the diagnosis of subcutaneous granuloma annulare. ( 29573450 )
2018
10
Clinical and Histopathological Features of Paraneoplastic Granuloma Annulare in Association with Solid Organ Malignancies: Case Control Study. ( 29920319 )
2018
11
Granuloma Annulare Skin Lesions in a Case of Sarcoidosis. ( 29644199 )
2018
12
Skin-colored papules on the elbows with a granuloma-annulare-like histological pattern. ( 29328553 )
2018
13
Granuloma Annulare and Radial Pulse Therapy: Preliminary Findings. ( 29410728 )
2018
14
Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study. ( 28099955 )
2017
15
Granuloma Annulare ( 29083715 )
2017
16
Disseminated eruptive granuloma annulare induced by levetiracetam. ( 28095713 )
2017
17
Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria. ( 29110020 )
2017
18
Granuloma annulare: a case treated with infliximab successfully. ( 28166622 )
2017
19
Perforating granuloma annulare within the red dye of a tattoo. ( 29050456 )
2017
20
Deep Granuloma Annulare Mimicking Inflamed Cysts in a Teenager. ( 28419540 )
2017
21
Antimalarial therapy for granuloma annulare: Results of a retrospective analysis. ( 28325398 )
2017
22
Florid Granuloma Annulare-Like Reaction in Regional Lymph Nodes After "Regression" of Red Pigment in Tattoos. ( 29140806 )
2017
23
Granuloma Annulare Possibly Secondary to Oral Treatment With Topiramate. ( 28712438 )
2017
24
Granuloma annulare treated with narrowband UVB phototherapy. ( 29267455 )
2017
25
Case for diagnosis. Patch granuloma annulare. ( 29186265 )
2017
26
Granuloma annulare: relationship to diabetes mellitus, thyroid disorders and tuberculin skin test. ( 28490896 )
2017
27
Case of successful treatment of subcutaneous granuloma annulare with local hyperthermia. ( 28636080 )
2017
28
Actinic Granuloma Annulare With Scarring and Open Comedones. ( 28244938 )
2017
29
Chronic Hepatitis with Liver Granulomas in a Patient with Granuloma Annulare: A Case Report and Review of the Literature. ( 28326206 )
2017
30
Borderline Tuberculoid Leprosy Masquerading as Granuloma Annulare: A Clinical and Histological Pitfall. ( 28328616 )
2017
31
Coexistence of morphea and granuloma annulare: a rare case report. ( 29166431 )
2017
32
Granuloma annulare can occur on a scar, mimicking sarcoidosis. ( 28929530 )
2017
33
Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction. ( 28946733 )
2017
34
Successful Treatment of Generalized Granuloma Annulare with Pentoxifylline. ( 28584765 )
2017
35
Granuloma Annulare: A Focused Review of Therapeutic Options. ( 29230666 )
2017
36
Consecutive occurrence of isotopic and isomorphic response in a patient: Patchy granuloma annulare arising in the site of herpes zoster scar and seborrhoeic dermatitis. ( 28670742 )
2017
37
Papular Granuloma Annulare of Palms and Soles. ( 29204409 )
2017
38
Granuloma Annulare Secondary to Vemurafenib Therapy for Lung Adenocarcinoma. ( 29036262 )
2017
39
Bacilli-containing granuloma with subsequent granuloma annulare-like eruptions following Bacillus Calmette-GuAcrin vaccination. ( 29373237 )
2017
40
Granuloma annulare associated with immune checkpoint inhibitors. ( 28983973 )
2017
41
A Case of Granuloma Annulare Associated with Secukinumab Use. ( 28611928 )
2017
42
Generalised granuloma annulare associated with myelodysplastic syndrome. ( 27212203 )
2016
43
Generalized Granuloma Annulare in a Cirrhotic Patient Treated with Narrowband Ultraviolet B Therapy. ( 26955167 )
2016
44
Pressure-induced localised granuloma annulare following use of an elbow splint. ( 27613591 )
2016
45
Pediatric Dermatology Photoquiz: A 9-Year Old Girl with Papules on Her Hands. Papular umbilicated granuloma annulare. ( 26758094 )
2016
46
Generalized granuloma annulare successfully treated with narrowband ultraviolet B and anti-hepatitis C virus therapy. ( 26891771 )
2016
47
Disseminated granuloma annulare responding to narrowband UVB phototherapy. ( 26580147 )
2016
48
Subcutaneous Granuloma Annulare: A Diagnostic Conundrum-Learning From Mistakes. ( 26785090 )
2016
49
Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. ( 27543209 )
2016
50
Vemurafenib-induced granuloma annulare. ( 26972200 )
2016

Variations for Granuloma Annulare

Expression for Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for Granuloma Annulare

Pathways related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 F13A1 TNFRSF1B VIM

GO Terms for Granuloma Annulare

Biological processes related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.8 F13A1 TNFRSF1B VIM

Sources for Granuloma Annulare

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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