MCID: GRN007
MIFTS: 40

Granuloma Annulare

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Granuloma Annulare

MalaCards integrated aliases for Granuloma Annulare:

Name: Granuloma Annulare 38 12 76 53 55 44 15 73
Granulome Annulare 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3777
ICD10 33 L92.0
MeSH 44 D016460
NCIt 50 C3470
SNOMED-CT 68 65508009
UMLS 73 C0085074

Summaries for Granuloma Annulare

NIH Rare Diseases : 53 Granuloma annulare (GA) is a long-term (chronic) skin disease consisting of a rash with reddish bumps (erythematous papules) arranged in a circle or ring pattern. The most commonly affected areas are the forearms, hands and feet. It may be localized or generalized. Localized GA is the most common form of GA (75% of the cases). The generalized form of GA (15% of cases) presents with numerous erythematous papules and plaques on the trunk and extremities. Less common forms of GA include subcutaneous, perforating, and patch variants. The underlying cause of granuloma annulare is unknown, but there are several factors that can trigger the disease such as trauma, insect bites, tuberculin skin testing, vaccinations, sun exposure, certain medications, and various viral infections. It is also more frequent in people who have diabetes, thyroid diseases and other, but most cases occur in healthy people. Some genetic factors may increase the chance to have the disease. The lesions associated with granuloma annulare usually resolve without treatment. Strong steroids (applied as a cream or injection) are sometimes used to clear the rash more quickly. Most symptoms will disappear within 2 years (even without treatment), but recurrence is common.

MalaCards based summary : Granuloma Annulare, also known as granulome annulare, is related to necrobiosis lipoidica and multicentric reticulohistiocytosis. An important gene associated with Granuloma Annulare is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways is Interleukin-4 and 13 signaling. The drugs Lidocaine and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and testes, and related phenotype is respiratory system.

Wikipedia : 76 Granuloma annulare is a fairly rare, chronic skin condition which presents as reddish bumps on the skin... more...

Related Diseases for Granuloma Annulare

Diseases related to Granuloma Annulare via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 necrobiosis lipoidica 31.0 GLI1 TNFRSF1B
2 multicentric reticulohistiocytosis 30.0 F13A1 VIM
3 fibrous histiocytoma 29.7 F13A1 VIM
4 diabetes mellitus 10.4
5 herpes zoster 10.4
6 lymphoma 10.3
7 mycosis fungoides 10.3
8 hepatitis 10.3
9 viral infectious disease 10.2
10 dermatitis 10.2
11 acquired immunodeficiency syndrome 10.2
12 thyroiditis 10.2
13 leukemia 10.2
14 uveitis 10.2
15 arthritis 10.1
16 hepatitis b 10.1
17 adenocarcinoma 10.1
18 lichen sclerosus 10.1
19 mid-dermal elastolysis 10.1
20 angiolipoma 10.1 F13A1 VIM
21 fibrous meningioma 10.1 F13A1 VIM
22 hepatocellular carcinoma 10.0
23 rheumatoid arthritis 10.0
24 temporal arteritis 10.0
25 hepatitis c virus 10.0
26 myelodysplastic syndrome 10.0
27 b-cell lymphomas 10.0
28 sarcoma 10.0
29 hepatitis c 10.0
30 syphilis 10.0
31 scabies 10.0
32 lichen planus 10.0
33 juvenile xanthogranuloma 10.0 F13A1 VIM
34 cutaneous fibrous histiocytoma 10.0 F13A1 VIM
35 erythema elevatum diutinum 10.0 F13A1 TNFRSF1B
36 hemangiopericytoma, malignant 10.0 F13A1 VIM
37 neutrophil migration 10.0
38 alopecia 10.0
39 erythema multiforme 10.0
40 lymphocytic leukemia 10.0
41 skin sarcoidosis 10.0
42 hyperparathyroidism 10.0
43 contact dermatitis 10.0
44 histiocytosis 10.0
45 secondary syphilis 10.0
46 granulomatous dermatitis 10.0
47 folliculitis 10.0
48 angiokeratoma 10.0
49 epithelioid sarcoma 10.0
50 vasculitis 10.0

Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to Granuloma Annulare

Symptoms & Phenotypes for Granuloma Annulare

MGI Mouse Phenotypes related to Granuloma Annulare:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 F13A1 GLI1 STAB1 TNFRSF1B VIM

Drugs & Therapeutics for Granuloma Annulare

Drugs for Granuloma Annulare (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Central Nervous System Depressants Phase 4
3 Peripheral Nervous System Agents Phase 4
4 Anti-Arrhythmia Agents Phase 4
5 Sodium Channel Blockers Phase 4
6 Anesthetics Phase 4
7 Anesthetics, Local Phase 4
8 Diuretics, Potassium Sparing Phase 4
9
Levofloxacin Approved, Investigational 100986-85-4 149096
10
Minocycline Approved, Investigational 10118-90-8 5281021
11
Rifampicin Approved 13292-46-1 5458213 5381226
12
Ofloxacin Approved 82419-36-1 4583
13 Renal Agents
14 Nucleic Acid Synthesis Inhibitors
15 Topoisomerase Inhibitors
16 Antibiotics, Antitubercular
17 Anti-Infective Agents, Urinary
18 Cytochrome P-450 CYP3A Inducers
19 Antitubercular Agents
20 Anti-Infective Agents
21 Cytochrome P-450 CYP1A2 Inhibitors
22 Anti-Bacterial Agents
23 Cytochrome P-450 Enzyme Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pain Outcomes Following Intralesional Corticosteroid Injections Not yet recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
3 Proteomic Analysis of Sweat in Cutaneous Conditions Unknown status NCT02768090 Not Applicable
4 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
5 UVA1 Light for Scleroderma and Similar Conditions Terminated NCT00476697 Not Applicable

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: granuloma annulare

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

MalaCards organs/tissues related to Granuloma Annulare:

41
Skin, Thyroid, Testes, Bone, B Cells, T Cells, Neutrophil

Publications for Granuloma Annulare

Articles related to Granuloma Annulare:

(show top 50) (show all 862)
# Title Authors Year
1
An unusual orbital tumor in an adult: Granuloma annulare. ( 30505978 )
2019
2
Pseudolymphomatous Granuloma Annulare: A Little-Known Variant. ( 29861038 )
2018
3
Granuloma Annulare-Like Granulomatous Reaction to Red Tattoo Pigment. ( 29658308 )
2018
4
Disseminated interstitial granuloma annulare associated with hepatocellular carcinoma. ( 29774572 )
2018
5
Granuloma Annulare in the Setting of Secukinumab. ( 29805815 )
2018
6
Subcutaneous granuloma annulare involving the scalp. ( 29205476 )
2018
7
Malignancy-associated generalized perforating granuloma annulare. ( 29318643 )
2018
8
Methotrexate treatment of generalized granuloma annulare: a retrospective case series. ( 29488435 )
2018
9
Acute-onset, painful acral granuloma annulare with unusual microcalcification. ( 29672826 )
2018
10
Usefulness of ultrasonography in the diagnosis of subcutaneous granuloma annulare. ( 29573450 )
2018
11
Clinical and Histopathological Features of Paraneoplastic Granuloma Annulare in Association with Solid Organ Malignancies: Case Control Study. ( 29920319 )
2018
12
Granuloma Annulare Skin Lesions in a Case of Sarcoidosis. ( 29644199 )
2018
13
Skin-colored papules on the elbows with a granuloma-annulare-like histological pattern. ( 29328553 )
2018
14
Two subsequent metachronous diseases: Granuloma annulare and colon adenocarcinoma. ( 30539883 )
2018
15
Granuloma annulare development in a patient with rheumatoid arthritis treated with tocilizumab: case-based review. ( 30523477 )
2018
16
A Case of Generalized Interstitial Granuloma Annulare and Arthritis Associated with Breast Cancer. ( 30281136 )
2018
17
Granuloma Annulare and Radial Pulse Therapy: Preliminary Findings. ( 29410728 )
2018
18
Paraneoplastic Generalized Granuloma Annulare in a Patient with Hepatocellular Carcinoma. ( 30065603 )
2018
19
Multiple granuloma annulare lesions presenting simultaneously with herpes zoster infection: Wolf's isotopic response. ( 30094303 )
2018
20
Programmed cell death protein-1 inhibitor-induced granuloma annulare and hypertrophic lichen planus masquerading as squamous cell carcinoma. ( 30094305 )
2018
21
Granuloma annulare presenting with a giant plaque, successfully treated with minocycline. ( 30147025 )
2018
22
Scanning electron microscopy of granuloma annulare. ( 30156630 )
2018
23
Comment on "Usefulness of ultrasonography in the diagnosis of subcutaneous granuloma annulare". ( 30397952 )
2018
24
Granuloma annulare on the palms in an elderly patient. ( 30484534 )
2018
25
Subcutaneous granuloma annulare in an HIV-positive patient. ( 30486766 )
2018
26
Evaluating the Unusual Histological Aspects of Granuloma Annulare: A Study of 30 Cases. ( 30505780 )
2018
27
Concomitant granuloma annulare and necrobiosis lipoidica: do they have a related pathogenesis? ( 30506562 )
2018
28
Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study. ( 28099955 )
2017
29
Granuloma Annulare ( 29083715 )
2017
30
Disseminated eruptive granuloma annulare induced by levetiracetam. ( 28095713 )
2017
31
Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria. ( 29110020 )
2017
32
Granuloma annulare: a case treated with infliximab successfully. ( 28166622 )
2017
33
Perforating granuloma annulare within the red dye of a tattoo. ( 29050456 )
2017
34
Deep Granuloma Annulare Mimicking Inflamed Cysts in a Teenager. ( 28419540 )
2017
35
Antimalarial therapy for granuloma annulare: Results of a retrospective analysis. ( 28325398 )
2017
36
Florid Granuloma Annulare-Like Reaction in Regional Lymph Nodes After "Regression" of Red Pigment in Tattoos. ( 29140806 )
2017
37
Granuloma Annulare Possibly Secondary to Oral Treatment With Topiramate. ( 28712438 )
2017
38
Granuloma annulare treated with narrowband UVB phototherapy. ( 29267455 )
2017
39
Case for diagnosis. Patch granuloma annulare. ( 29186265 )
2017
40
Granuloma annulare: relationship to diabetes mellitus, thyroid disorders and tuberculin skin test. ( 28490896 )
2017
41
Case of successful treatment of subcutaneous granuloma annulare with local hyperthermia. ( 28636080 )
2017
42
Actinic Granuloma Annulare With Scarring and Open Comedones. ( 28244938 )
2017
43
Chronic Hepatitis with Liver Granulomas in a Patient with Granuloma Annulare: A Case Report and Review of the Literature. ( 28326206 )
2017
44
Borderline Tuberculoid Leprosy Masquerading as Granuloma Annulare: A Clinical and Histological Pitfall. ( 28328616 )
2017
45
Coexistence of morphea and granuloma annulare: a rare case report. ( 29166431 )
2017
46
Granuloma annulare can occur on a scar, mimicking sarcoidosis. ( 28929530 )
2017
47
Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction. ( 28946733 )
2017
48
Successful Treatment of Generalized Granuloma Annulare with Pentoxifylline. ( 28584765 )
2017
49
Granuloma Annulare: A Focused Review of Therapeutic Options. ( 29230666 )
2017
50
Consecutive occurrence of isotopic and isomorphic response in a patient: Patchy granuloma annulare arising in the site of herpes zoster scar and seborrhoeic dermatitis. ( 28670742 )
2017

Variations for Granuloma Annulare

Expression for Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for Granuloma Annulare

Pathways related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 F13A1 TNFRSF1B VIM

GO Terms for Granuloma Annulare

Biological processes related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 8.8 F13A1 TNFRSF1B VIM

Sources for Granuloma Annulare

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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