MCID: GRN007
MIFTS: 43

Granuloma Annulare

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Granuloma Annulare

MalaCards integrated aliases for Granuloma Annulare:

Name: Granuloma Annulare 12 73 20 54 44 15 37 17 70 32
Granulome Annulare 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3777
MeSH 44 D016460
NCIt 50 C3470
SNOMED-CT 67 200953005
ICD10 32 L92.0
UMLS 70 C0085074

Summaries for Granuloma Annulare

GARD : 20 Granuloma annulare (GA) is skin disorder that most often causes a rash with red bumps (erythematous papules) arranged in a circle or ring pattern (annular). GA is not contagious and is not cancerous. The rash may be localized or generalized. Localized GA is the most common form of GA (75% of the cases) and usually affects the forearms, hands, or feet. The generalized form of GA (15% of cases) presents with numerous erythematous papules that form larger, slightly raised patches (plaques) anywhere on the body, including the palms of hands and soles of feet. The plaques may or may not be in the ring pattern and can vary in color. Less common forms of GA include subcutaneous, perforating, and patch variants. The underlying cause of GA is unknown, but there are several factors that may trigger the disorder, including injury to the skin, viral infections, and certain medications and medical diseases. However, most cases of GA develop in healthy people. Some researchers propose unknown genetic factors may increase a person's risk to develop GA. Diagnosis of GA is made by the appearance of skin lesions and lack of other physical findings or symptoms. GA may be confirmed by a biopsy and tests may be performed to rule out other associated diseases. GA usually goes away without treatment within a few weeks to several years. However GA can sometimes last for decades, especially the generalized form. Steroids creams or injections and other therapies may be used to clear the rash more quickly, but are not successful in all cases, especially for those with the generalized form. Even after GA completely goes away, it may develop again.

MalaCards based summary : Granuloma Annulare, also known as granulome annulare, is related to erythema elevatum diutinum and pityriasis rosea. An important gene associated with Granuloma Annulare is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Innate Immune System and Tight junction. The drugs Lidocaine and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and neutrophil.

Wikipedia : 73 Granuloma annulare is a fairly rare, chronic skin condition which presents as reddish bumps on the skin... more...

Related Diseases for Granuloma Annulare

Diseases related to Granuloma Annulare via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)
# Related Disease Score Top Affiliating Genes
1 erythema elevatum diutinum 30.7 F13A1 CD1E
2 pityriasis rosea 30.2 CD1E CD1A
3 cutaneous fibrous histiocytoma 30.1 VIM F13A1 CD68
4 fibrous histiocytoma 30.1 VIM F13A1 CD68
5 multicentric reticulohistiocytosis 30.0 VIM F13A1 CD68 CD1E
6 necrobiosis lipoidica 30.0 TNF GLI1 CD68 CD1E CD1B CD1A
7 iridocyclitis 29.9 TNF CD4
8 histiocytosis 29.8 TNF CD1C CD1A
9 tertiary syphilis 29.7 TNF CD4
10 lymph node tuberculosis 29.7 TNF CD4
11 retinal vasculitis 29.7 TNF CD4
12 skin sarcoidosis 29.7 TNF CD4 CD1C CD1B
13 childhood type dermatomyositis 29.6 TNF CD4
14 skin disease 29.6 VIM TNF F13A1 CD4 CD1C CD1A
15 contact dermatitis 29.6 TNF CD4 CD1D
16 temporal arteritis 29.5 TNF CD68 CD4
17 lichen nitidus 29.4 CD1E CD1C CD1B CD1A
18 pharyngitis 29.4 TNF CD4 CD1A
19 tuberculoid leprosy 29.4 TNF CD4 CD1B
20 granulomatous dermatitis 29.3 TNF CD68 CD4 CD1E CD1C CD1B
21 allergic contact dermatitis 29.2 TNF CD4 CD1D
22 disease by infectious agent 29.2 TNF CD4 CD1C CD1A
23 seborrheic dermatitis 29.0 CD4 CD1E CD1C CD1B CD1A
24 keratosis, seborrheic 28.9 CD1E CD1D CD1C CD1B CD1A
25 exophthalmos 28.9 CD68 CD1E CD1D CD1C CD1B CD1A
26 folliculitis 28.9 CD4 CD1E CD1D CD1C CD1B CD1A
27 mycobacterium tuberculosis 1 28.6 TNF CD4 CD1C CD1B CD1A
28 leprosy 3 28.3 TNF CD68 CD4 CD1E CD1D CD1C
29 sarcoidosis 1 10.7
30 herpes zoster 10.6
31 lipid metabolism disorder 10.5
32 vasculitis 10.5
33 hansen's disease 10.4
34 mycosis fungoides 10.4
35 acquired immunodeficiency syndrome 10.4
36 localized scleroderma 10.4
37 tumor of meninges 10.3 VIM F13A1
38 uveitis 10.3
39 angiolipoma 10.3 VIM F13A1
40 fibrous meningioma 10.3 VIM F13A1
41 hashimoto thyroiditis 10.3
42 exanthem 10.3
43 pustulosis of palm and sole 10.3
44 epithelioid sarcoma 10.3
45 thyroiditis 10.3
46 psoriasis 10.3
47 heart lymphoma 10.3 VIM CD68
48 congenital epulis 10.3 VIM CD68
49 epulis 10.3 VIM CD68
50 cutaneous leiomyosarcoma 10.3 VIM CD68

Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to Granuloma Annulare

Symptoms & Phenotypes for Granuloma Annulare

Drugs & Therapeutics for Granuloma Annulare

Drugs for Granuloma Annulare (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Anti-Arrhythmia Agents Phase 4
3 Anesthetics Phase 4
4 Sodium Channel Blockers Phase 4
5 Anesthetics, Local Phase 4
6 Diuretics, Potassium Sparing Phase 4
7
Tofacitinib Approved, Investigational Phase 1 477600-75-2
8 Protein Kinase Inhibitors Phase 1
9
Ofloxacin Approved 82419-36-1 4583
10
Minocycline Approved, Investigational 10118-90-8 5281021
11
Rifampicin Approved 13292-46-1 5381226 5458213
12
Levofloxacin Approved, Investigational 100986-85-4 149096

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Completed NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 The Effectiveness of UVB Irradiation in the Treatment of Skin Conditions With Altered Dermal Matrix: An Open Pilot Study Completed NCT00129428 Phase 1, Phase 2
3 Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare Active, not recruiting NCT03910543 Phase 1 Tofacitinib 5 mg twice daily
4 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
5 The Effectiveness of UVA1 Irradiation in the Treatment of Skin Conditions With Altered Dermal Matrix: An Open Pilot Study Terminated NCT00476697

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: granuloma annulare

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

MalaCards organs/tissues related to Granuloma Annulare:

40
Skin, Bone Marrow, Neutrophil, Thyroid, Myeloid, T Cells, Tongue

Publications for Granuloma Annulare

Articles related to Granuloma Annulare:

(show top 50) (show all 1396)
# Title Authors PMID Year
1
Granuloma Annulare: A Focused Review of Therapeutic Options. 61 20
29230666 2018
2
Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. 20 61
27543209 2016
3
Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. 61 20
27543210 2016
4
Granuloma annulare: an immunohistochemical study. 54 61
8040462 1994
5
Reactive granulomatous dermatitis as a histological pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: a study of 52 patients. 61
33098595 2021
6
[Granuloma annulare after herpes zoster: Wolf's isotopic response]. 61
33720559 2021
7
Anti-neutrophil cytoplasmic antibodies-negative Churg-Strauss syndrome presenting as granuloma annulare-like lesions: An unusual cutaneous presentation and a diagnostic pitfall. 61
33769746 2021
8
Generalized granuloma annulare associated with interstitial lung disease: Good response to doxycycline. 61
33565181 2021
9
Generalized granuloma annulare-like eruption secondary to acute Epstein-Barr virus infection. 61
33107027 2021
10
Granuloma annulare: report of 13 patients treated with photodynamic therapy. 61
32936955 2021
11
Oral dapsone for the treatment of generalized granuloma annulare: a retrospective case series. 61
33753254 2021
12
New targets in treating granuloma annulare. 61
33713770 2021
13
Generalized perforating granuloma annulare: a case report. 61
33569897 2021
14
Photoinduced Granuloma Annulare Confirmed by Experimental Exposure to UVA Light. 61
33075292 2021
15
Peri-and intraneural mucinosis in painful, interstitial granuloma annulare of the digit. 61
32810298 2021
16
Granuloma annulare triggered by SARS-CoV-2 infection: Immunohistochemical staining. 61
33599069 2021
17
Localized Versus Generalized Granuloma Annulare: A Retrospective Review of 407 Patients. 61
33625247 2021
18
Kaposi sarcoma misdiagnosed as granuloma annulare: A case of mistaken identity. 61
33405248 2021
19
Granulomatous Cutaneous Drug Eruptions: A Systematic Review. 61
33108647 2021
20
A Review of the Dermatological Complications of Giant Cell Arteritis. 61
33790612 2021
21
Granuloma annulare triggered by SARS-CoV-2 infection. The first reported case. 61
33169426 2021
22
Generalized granuloma annulare after pneumococcal vaccination. 61
33267970 2021
23
Recalcitrant generalized granuloma annulare treated successfully with dupilumab. 61
33318988 2021
24
Tildrakizumab ineffective in generalized granuloma annulare. 61
33318989 2021
25
Treatment of granuloma annulare and related granulomatous diseases with sulphasalazine: a series of 16 cases. 61
32216136 2021
26
Granuloma annulare following initiation of interleukin-17a antagonist. 61
33511635 2021
27
Granuloma annulare subtypes: sonographic features and clinicopathological correlation. 61
33453055 2021
28
Granuloma annulare show diffuse 18F-fluorodeoxyglucose uptake on PET/CT. Report of a case. 61
33342756 2020
29
Treatment of granuloma annulare and suppression of proinflammatory cytokine activity with tofacitinib. 61
33317858 2020
30
Granuloma Annulare - A Manifestation of Primary Cutaneous Mucinous Carcinoma? 61
33520503 2020
31
Scleromyxedema. 61
33373143 2020
32
Cyclosporin in dermatology: A practical compendium. 61
32602210 2020
33
A retrospective review of UVA1 treatment: An Australian experience from a single centre. 61
32390138 2020
34
Interstitial granulomatous dermatitis following tocilizumab, a paradoxical reaction? 61
32816393 2020
35
Oral isotretinoin for the treatment of dermatologic conditions other than acne: a systematic review and discussion of future directions. 61
33151346 2020
36
Periorbital granuloma annulare following mesotherapy. 61
32975346 2020
37
Development of Granuloma Annulare in Patients on Biologic Therapies: A Systematic Review. 61
33253852 2020
38
Treatment of recalcitrant reactive granulomatous dermatitis: Granuloma annulare subtype with etanercept. 61
32713130 2020
39
Systemic B-cell lymphoma with skin manifestation clinically resembling granuloma annulare. 61
33245143 2020
40
A case of generalized granuloma annulare successfully treated by hydroxychloroquine. 61
32588505 2020
41
Subcutaneous granuloma annulare induced by acetazolamide. 61
32892341 2020
42
Generalized granuloma annulare: A widespread response to limited application of compounded 2% topical tofacitinib. 61
33005718 2020
43
Granuloma annulare after Botulonium toxin A injection: A rare association. 61
32030860 2020
44
Saline in Dermatology: A literature review. 61
33098717 2020
45
Patch-type granuloma annulare: An institution-based study of 23 cases. 61
32279342 2020
46
Granuloma annulare-like eruption in chronic lymphocytic leukemia. 61
33054936 2020
47
Middermal Elastolysis-A Possible End Stage of Granuloma Annulare. 61
32401268 2020
48
Anti-CTLA-4 therapy-associated granuloma annulare in chronic myelomonocytic leukemia. 61
33456170 2020
49
Pseudolymphomatous Granuloma Annulare: A Case Report. 61
32911683 2020
50
Granuloma annulare arising under systemic psoriasis therapy successfully treated with adalimumab. 61
32875031 2020

Variations for Granuloma Annulare

Expression for Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for Granuloma Annulare

GO Terms for Granuloma Annulare

Cellular components related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 TNF CD1E CD1D CD1C CD1B CD1A
2 integral component of plasma membrane GO:0005887 9.8 TNF CD4 CD1E CD1D CD1C CD1A
3 cell surface GO:0009986 9.71 TNF CD4 CD1D CD1B
4 lysosome GO:0005764 9.65 CD68 CD1E CD1D CD1C CD1B
5 endosome GO:0005768 9.63 CD68 CD1E CD1D CD1C CD1B CD1A
6 endosome membrane GO:0010008 9.35 CD68 CD1D CD1C CD1B CD1A
7 external side of plasma membrane GO:0009897 9.17 TNF CD4 CD1E CD1D CD1C CD1B

Biological processes related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.8 CD4 CD1E CD1C CD1B CD1A
2 immune system process GO:0002376 9.8 CD4 CD1E CD1D CD1C CD1B CD1A
3 immune response GO:0006955 9.8 TNF CD4 CD1E CD1D CD1C CD1B
4 cytokine-mediated signaling pathway GO:0019221 9.76 VIM TNF F13A1 CD4
5 regulation of immune response GO:0050776 9.73 CD1D CD1C CD1B CD1A
6 cellular response to lipopolysaccharide GO:0071222 9.65 VIM TNF CD68
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
8 T cell selection GO:0045058 9.37 CD4 CD1D
9 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
10 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Granuloma Annulare

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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