MCID: GRN007
MIFTS: 45

Granuloma Annulare

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Granuloma Annulare

MalaCards integrated aliases for Granuloma Annulare:

Name: Granuloma Annulare 12 74 52 54 43 15 37 17 71 32
Granulome Annulare 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3777
MeSH 43 D016460
NCIt 49 C3470
SNOMED-CT 67 65508009
ICD10 32 L92.0
UMLS 71 C0085074

Summaries for Granuloma Annulare

NIH Rare Diseases : 52 Granuloma annulare (GA) is skin disorder that most often causes a rash with red bumps (erythematous papules) arranged in a circle or ring pattern (annular). GA is not contagious and is not cancerous. The rash may be localized or generalized. Localized GA is the most common form of GA (75% of the cases) and usually affects the forearms, hands, or feet. The generalized form of GA (15% of cases) presents with numerous erythematous papules that form larger, slightly raised patches (plaques) anywhere on the body, including the palms of hands and soles of feet. The plaques may or may not be in the ring pattern and can vary in color. Less common forms of GA include subcutaneous, perforating, and patch variants. The underlying cause of GA is unknown, but there are several factors that may trigger the disorder, including injury to the skin, viral infections, and certain medications and medical diseases. However, most cases of GA develop in healthy people. Some researchers propose unknown genetic factors may increase a person's risk to develop GA. Diagnosis of GA is made by the appearance of skin lesions and lack of other physical findings or symptoms. GA may be confirmed by a biopsy and tests may be performed to rule out other associated diseases. GA usually goes away without treatment within a few weeks to several years. However GA can sometimes last for decades, especially the generalized form. Steroids creams or injections and other therapies may be used to clear the rash more quickly, but are not successful in all cases, especially for those with the generalized form. Even after GA completely goes away, it may develop again.

MalaCards based summary : Granuloma Annulare, also known as granulome annulare, is related to epithelioid sarcoma and erythema elevatum diutinum. An important gene associated with Granuloma Annulare is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways are Innate Immune System and Tight junction. The drugs Lidocaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Granuloma annulare is a fairly rare, chronic skin condition which presents as reddish bumps on the skin... more...

Related Diseases for Granuloma Annulare

Diseases related to Granuloma Annulare via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 307)
# Related Disease Score Top Affiliating Genes
1 epithelioid sarcoma 30.9 VIM CD68
2 erythema elevatum diutinum 30.6 TNFRSF1B F13A1
3 necrobiosis lipoidica 30.3 TNFRSF1B GLI1 CD68 CD163
4 leprosy 3 30.2 CD1E CD1C CD1B
5 folliculitis 29.9 CD1E CD1B CD1A
6 multicentric reticulohistiocytosis 29.8 VIM F13A1 CD68 CD1E
7 mycosis fungoides 29.7 TNFRSF1B CD1C CD1B CD1A
8 granulomatous dermatitis 29.7 TNFRSF1B CD68 CD1B CD163
9 lichen nitidus 29.6 CD1E CD1B CD1A
10 histiocytosis 29.4 CD1C CD1A CD163
11 skin sarcoidosis 29.3 TNFRSF1B CD1E CD1C CD1B CD1A
12 pharyngitis 29.2 TNFRSF1B CD1A
13 mycobacterium tuberculosis 1 29.2 TNFRSF1B CD1C CD1B CD1A
14 fibrous histiocytoma 29.1 VIM F13A1 CD68 CD163
15 skin disease 29.0 VIM TNFRSF1B F13A1 CD1C CD1A CD163
16 seborrheic dermatitis 29.0 CD1E CD1C CD1B CD1A
17 keratosis, seborrheic 29.0 CD1E CD1C CD1B CD1A
18 histiocytoma 28.8 VIM CD68 CD1A CD163
19 exophthalmos 28.2 CD68 CD1E CD1D CD1C CD1B CD1A
20 sarcoidosis 1 10.6
21 herpes zoster 10.5
22 vasculitis 10.4
23 allergic hypersensitivity disease 10.4
24 immune deficiency disease 10.4
25 tumor of meninges 10.4 VIM F13A1
26 diabetes mellitus 10.4
27 hypothyroidism 10.3
28 hansen's disease 10.3
29 acquired immunodeficiency syndrome 10.3
30 angiolipoma 10.3 VIM F13A1
31 congenital epulis 10.3 VIM CD68
32 epulis 10.3 VIM CD68
33 heart lymphoma 10.3 VIM CD68
34 lipid metabolism disorder 10.3
35 villonodular synovitis 10.3 VIM CD68
36 fibrous meningioma 10.3 VIM F13A1
37 uveitis 10.3
38 localized scleroderma 10.3
39 alk+ histiocytosis 10.3 F13A1 CD1A
40 esophageal tuberculosis 10.2 TNFRSF1B CD68
41 granulomatous orchitis 10.2 CD68 CD1E
42 hashimoto thyroiditis 10.2
43 exanthem 10.2
44 lymphoma 10.2
45 dermatitis 10.2
46 thyroiditis 10.2
47 epidermal appendage tumor 10.2 GLI1 CD68
48 uveoparotid fever 10.2 TNFRSF1B CD68
49 autoimmune disease 10.2
50 lichen sclerosus et atrophicus 10.2

Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to Granuloma Annulare

Symptoms & Phenotypes for Granuloma Annulare

GenomeRNAi Phenotypes related to Granuloma Annulare according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.65 CD163
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.65 CD163
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.65 CD163
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.65 CD163 CD1C VIM
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.65 CD163
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.65 VIM
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.65 CD163 VIM
8 Decreased Hepatitis C virus replication GR00180-A-1 9.33 CD1D TNFRSF1B VIM
9 Reduced mammosphere formation GR00396-S 9.02 CD1A CD1D F13A1 TNFRSF1B VIM

MGI Mouse Phenotypes related to Granuloma Annulare:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 CD163 CD1D F13A1 GLI1 TNFRSF1B VIM

Drugs & Therapeutics for Granuloma Annulare

Drugs for Granuloma Annulare (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2 Anesthetics, Local Phase 4
3 Anti-Arrhythmia Agents Phase 4
4 Anesthetics Phase 4
5 Sodium Channel Blockers Phase 4
6 Central Nervous System Depressants Phase 4
7 Diuretics, Potassium Sparing Phase 4
8
Tofacitinib Approved, Investigational Phase 1 477600-75-2
9 Protein Kinase Inhibitors Phase 1
10
Levofloxacin Approved, Investigational 100986-85-4 149096
11
Minocycline Approved, Investigational 10118-90-8 5281021
12
Rifampicin Approved 13292-46-1 5458213 5381226
13
Ofloxacin Approved 82419-36-1 4583
14 Anti-Infective Agents
15 Antitubercular Agents
16 Renal Agents
17 Cytochrome P-450 CYP3A Inducers
18 Antibiotics, Antitubercular
19 Cytochrome P-450 Enzyme Inhibitors
20 Topoisomerase Inhibitors
21 Anti-Bacterial Agents
22 Anti-Infective Agents, Urinary
23 Cytochrome P-450 CYP1A2 Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Recruiting NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
2 The Effectiveness of UVB Irradiation in the Treatment of Skin Conditions With Altered Dermal Matrix: An Open Pilot Study Completed NCT00129428 Phase 1, Phase 2
3 The Effectiveness of UVA1 and UVB Irradiation in the Treatment of Inflammatory Dermatoses: An Open Pilot Study Terminated NCT00129415 Phase 1, Phase 2
4 Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare Recruiting NCT03910543 Phase 1 Tofacitinib 5 mg twice daily
5 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
6 The Effectiveness Of UVA1 Irradiation In The Treatment Of Skin Conditions With Altered Dermal Matrix: A Controlled, Cross-Over Study Completed NCT00476801
7 The Effectiveness of UVA1 Irradiation in the Treatment of Skin Conditions With Altered Dermal Matrix: An Open Pilot Study Terminated NCT00476697
8 Proteomic Analysis of Sweat in Cutaneous Inflammatory and Neoplastic Conditions Withdrawn NCT02768090

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: granuloma annulare

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

MalaCards organs/tissues related to Granuloma Annulare:

40
Skin, T Cells, Testes, Thyroid, B Cells, Bone, Thymus

Publications for Granuloma Annulare

Articles related to Granuloma Annulare:

(show top 50) (show all 1321)
# Title Authors PMID Year
1
Granuloma Annulare: A Focused Review of Therapeutic Options. 61 52
29230666 2018
2
Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. 61 52
27543209 2016
3
Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. 61 52
27543210 2016
4
Granuloma annulare: an immunohistochemical study. 54 61
8040462 1994
5
Case of granuloma annulare after using tocilizumab. 61
32011748 2020
6
Granuloma annulare after Botulonium toxin A injection: A rare association. 61
32030860 2020
7
Erdheim-Chester disease: expanding the spectrum of cutaneous manifestations. 61
31120137 2020
8
Generalized Necrobiotic Palisading Granulomatous Follicular Eruption: A Peculiar Pustular Variant of Perforating Granuloma Annulare or an Individualized Disease? 61
31313693 2020
9
Concurrence of generalized perforating and subcutaneous granuloma annulare in a 4-year-old boy with latent tuberculosis infection successfully treated with low-dose hydroxychloroquine. 61
31762065 2020
10
Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment, and Prevention Programs. 61
31994473 2020
11
Treatment of granuloma annulare with tofacitinib 2% ointment. 61
31909145 2020
12
Granuloma annulare skin profile shows activation of Th1, Th2, and JAK pathways. 61
31870914 2019
13
Case of post-herpetic, isotopic granuloma annulare (GA), followed by generalized GA. 61
31553074 2019
14
Treatment of generalized granuloma annulare with apremilast: A report of 2 cases. 61
31763422 2019
15
Pentoxifylline as a treatment for granuloma annulare. 61
31115037 2019
16
Immune checkpoint inhibitors and the development of granulomatous reactions. 61
30092327 2019
17
Patch granuloma annulare of the legs. 61
31471095 2019
18
Granuloma Annulare Induced by Pregabalin. 61
31688069 2019
19
Granuloma annulare: A rare dermatological manifestation of diabetes mellitus. 61
31742181 2019
20
Infliximab reduces activated myeloid dendritic cells, different macrophage subsets and CXCR3-positive cells in granuloma annulare. 61
31290564 2019
21
Teledermatology management of difficult-to-treat dermatoses in the Faroe Islands. 61
31545386 2019
22
Adalimumab-induced Anti-neutrophilic Cytoplasmic Antibody Vasculitis: A Rare Complication of an Increasingly Common Treatment. 61
31700711 2019
23
Granuloma annulare: strengthening potential associations and pentoxifylline as a therapeutic option. 61
31464543 2019
24
Granuloma annulare. 61
31528105 2019
25
Concomitant granuloma annulare and necrobiosis lipoidica: do they have a related pathogenesis? 61
30506562 2019
26
Granuloma annulare presenting as firm nodules on the forehead and scalp in a child. 61
31603970 2019
27
Refractory Generalized Granuloma Annulare Treated With Oral Apremilast. 61
31433459 2019
28
Patch granuloma annulare: clinicopathological characteristics and response to phototherapy. 61
30609014 2019
29
The interstitial variant of granuloma annulare: Clinicopathologic study of 69 cases with a comparison with conventional granuloma annulare. 61
30883851 2019
30
Lack of an association between generalized granuloma annulare and malignancy: A case-control study. 61
30826288 2019
31
Generalized granuloma annulare responsive to narrowband UVB. 61
31348464 2019
32
Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. 61
31185230 2019
33
Non-infectious granulomatous dermatoses. 61
31115996 2019
34
The role of biologics in the treatment of chronic granuloma annulare. 61
30618205 2019
35
Perforating Granuloma Annulare Appearing as a Psoriasiform Lesion. 61
31543770 2019
36
Deep ulcerating granuloma annulare resulting in impaired function of the elbow. 61
30821415 2019
37
Giant Cell Arteritis with Generalized Granuloma Annulare. 61
30568109 2019
38
Presumed Choroidal Granuloma Annulare Mimicking Choroidal Lymphoma. 61
30998257 2019
39
Localized Perforating Granuloma Annulare. 61
31032789 2019
40
Unilateral granuloma annulare in association with pyoderma gangrenosum and chronic lymphocytic leukemia. 61
30982302 2019
41
Pseudolymphomatous Granuloma Annulare: A Little-Known Variant. 61
29861038 2019
42
An unusual orbital tumor in an adult: Granuloma annulare. 61
30505978 2019
43
Granuloma annulare: a retrospective series of 133 patients. 61
30893387 2019
44
Subcutaneous granuloma annulare in an HIV-positive patient. 61
30486766 2019
45
Treatment of resistant granuloma annulare with Rifampin, Norfloxacin, and Minocycline combination therapy. 61
30717571 2019
46
A Case of Generalized Interstitial Granuloma Annulare and Arthritis Associated with Breast Cancer. 61
30281136 2019
47
Granuloma annulare development in a patient with rheumatoid arthritis treated with tocilizumab: case-based review. 61
30523477 2019
48
Learning From Success and Failure: Biologics for Non-approved Skin Diseases. 61
31440261 2019
49
Disseminated interstitial granuloma annulare associated with hepatocellular carcinoma. 61
29774572 2019
50
Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises. 61
31096219 2019

Variations for Granuloma Annulare

Expression for Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for Granuloma Annulare

GO Terms for Granuloma Annulare

Cellular components related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 VIM TNFRSF1B CD68 CD1E CD1D CD1C
2 lysosome GO:0005764 9.65 CD68 CD1E CD1D CD1C CD1B
3 endosome GO:0005768 9.63 CD68 CD1E CD1D CD1C CD1B CD1A
4 endosome membrane GO:0010008 9.35 CD68 CD1D CD1C CD1B CD1A
5 external side of plasma membrane GO:0009897 9.1 CD1E CD1D CD1C CD1B CD1A CD163

Biological processes related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD1E CD1D CD1C CD1B CD1A
2 immune response GO:0006955 9.73 TNFRSF1B CD1E CD1D CD1C CD1B CD1A
3 adaptive immune response GO:0002250 9.71 CD1E CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.62 CD1D CD1C CD1B CD1A
5 cellular response to lipopolysaccharide GO:0071222 9.61 VIM TNFRSF1B CD68
6 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
7 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
8 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Granuloma Annulare

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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