MCID: GRN004
MIFTS: 30

Granulomatous Amebic Encephalitis

Categories: Infectious diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Granulomatous Amebic Encephalitis

MalaCards integrated aliases for Granulomatous Amebic Encephalitis:

Name: Granulomatous Amebic Encephalitis 12 54 15 74 3 3
Granulomatous Amebic Encephalitis Due to Acanthamoeba 12
Acanthamoeba Granulomatous Encephalitis 12
Granulomatous Amoebic Encephalitis 12
Acanthamoeba Encephalitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050246
UMLS 74 C0338428

Summaries for Granulomatous Amebic Encephalitis

NIH Rare Diseases : 54 Granulomatous amebic encephalitis is a life-threatening infection of the brain caused by the free-living amoebae Acanthamoeba spp., Balamuthia mandrillaris and Sappinia pedata. Acanthamoeba species, are commonly found in lakes, swimming pools, tap water, and heating and air conditioning units. The disease affects immunocompromised peple and is very serious. Symptoms include mental status changes, loss of coordination, fever, muscular weakness or partial paralysis affecting one side of the body, double vision, sensitivity to light and other neurologic problems. The diagnosis is difficult and is often made at advanced stages. Tests useful in the diagnosis include brain scans, biopsies, or spinal taps and in disseminated disease, biopsy of the involved sites and testing by the laboratory experts. Early diagnosis is important for the prognosis. No single drug is effective; hence multiple antibiotics are needed for successful treatment. A combination of surgical and medical interventions involving multiple specialty experts is required to prevent death and morbidity in survivors.

MalaCards based summary : Granulomatous Amebic Encephalitis, also known as granulomatous amebic encephalitis due to acanthamoeba, is related to amoebiasis due to free-living amoebae and encephalitis. An important gene associated with Granulomatous Amebic Encephalitis is GMPPB (GDP-Mannose Pyrophosphorylase B), and among its related pathways/superpathways are One carbon pool by folate and Renin secretion. Affiliated tissues include brain, skin and lung.

Disease Ontology : 12 A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

CDC : 3 Acanthamoeba is a microscopic, free-living ameba, or amoeba* (single-celled living organism), that can cause rare**, but severe infections of the eye, skin, and central nervous system. The ameba is found worldwide in the environment in water and soil. The ameba can be spread to the eyes through contact lens use, cuts, or skin wounds or by being inhaled into the lungs. Most people will be exposed to Acanthamoeba during their lifetime, but very few will become sick from this exposure. The three diseases caused by Acanthamoeba are:

Wikipedia : 77 Granulomatous amoebic encephalitis (GAE) is a central nervous system disease caused by certain species... more...

Related Diseases for Granulomatous Amebic Encephalitis

Diseases related to Granulomatous Amebic Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 amoebiasis due to free-living amoebae 11.5
2 encephalitis 10.8
3 hematopoietic stem cell transplantation 10.2
4 leukemia, acute lymphoblastic 10.1
5 leukemia 10.1
6 lymphocytic leukemia 10.1
7 pneumonia 10.1
8 systemic lupus erythematosus 10.1
9 diabetes mellitus 10.1
10 lupus erythematosus 10.1
11 cryoglobulinemia 10.0
12 neu-laxova syndrome 1 9.9 PHGDH PSAT1
13 serine deficiency 9.9 PHGDH PSAT1
14 phosphoserine aminotransferase deficiency 9.7 PHGDH PSAT1
15 primary amebic meningoencephalitis 9.2 ADCY6 CACNA1S GMPPB PSAT1

Graphical network of the top 20 diseases related to Granulomatous Amebic Encephalitis:



Diseases related to Granulomatous Amebic Encephalitis

Symptoms & Phenotypes for Granulomatous Amebic Encephalitis

Drugs & Therapeutics for Granulomatous Amebic Encephalitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Amebic Encephalitis

Genetic Tests for Granulomatous Amebic Encephalitis

Anatomical Context for Granulomatous Amebic Encephalitis

MalaCards organs/tissues related to Granulomatous Amebic Encephalitis:

42
Brain, Skin, Lung, Testes, Eye, Heart

Publications for Granulomatous Amebic Encephalitis

Articles related to Granulomatous Amebic Encephalitis:

(show all 29)
# Title Authors Year
1
Granulomatous amebic encephalitis caused by Acanthamoeba in an immuncompetent child. ( 30511552 )
2018
2
Fatal Granulomatous Amebic Encephalitis in a Heart Transplant Patient: Clinical, Radiographic, and Autopsy Findings. ( 30295806 )
2018
3
Balamuthia mandrillaris Granulomatous Amebic Encephalitis With Renal Dissemination in a Previously Healthy Child: Case Report and Review of the Pediatric Literature. ( 29096002 )
2017
4
Granulomatous amebic encephalitis caused by Acanthamoeba sp. in an immunocompetent Mexican adult. ( 28700070 )
2017
5
Management of granulomatous amebic encephalitis: Laboratory diagnosis and treatment. ( 25709949 )
2015
6
Assessment of blood-brain barrier penetration of miltefosine used to treat a fatal case of granulomatous amebic encephalitis possibly caused by an unusual Balamuthia mandrillaris strain. ( 26329128 )
2015
7
AIDS Presenting as Granulomatous Amebic Encephalitis: PET and MR Imaging correlation. ( 25678445 )
2015
8
Granulomatous amebic encephalitis following hematopoietic stem cell transplantation. ( 26539322 )
2015
9
Fatal Granulomatous Amebic Encephalitis Due to Balamuthia mandrillaris in New Mexico: A Case Report. ( 25734132 )
2014
10
Granulomatous amebic encephalitis: an under-recognized cause of infectious mortality after hematopoietic stem cell transplantation. ( 21338461 )
2011
11
Granulomatous amebic encephalitis in a child with acute lymphoblastic leukemia successfully treated with multimodal antimicrobial therapy and hyperbaric oxygen. ( 21084511 )
2011
12
A rare but fatal case of granulomatous amebic encephalitis with brain abscess: the first case reported from Turkey. ( 19621290 )
2009
13
First case of granulomatous amebic encephalitis caused by Acanthamoeba castellanii in Taiwan. ( 19635883 )
2009
14
Demonstration of presence of acanthamoeba mitochondrial DNA in brain tissue and cerebrospinal fluid by PCR in samples from a patient who died of granulomatous amebic encephalitis. ( 17409212 )
2007
15
Granulomatous amebic encephalitis in a multivisceral transplant recipient. ( 16618348 )
2006
16
Cytopathogenicity of Balamuthia mandrillaris, an opportunistic causative agent of granulomatous amebic encephalitis. ( 17123409 )
2006
17
Inability to make a premortem diagnosis of Acanthamoeba species infection in a patient with fatal granulomatous amebic encephalitis. ( 15956445 )
2005
18
Fatal granulomatous amebic encephalitis caused by Balamuthia mandrillaris presenting as a skin lesion. ( 14726864 )
2004
19
Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway. ( 15338290 )
2004
20
Current research on free-living amebae causing granulomatous amebic encephalitis. ( 11906072 )
2001
21
Granulomatous amebic encephalitis in a patient with AIDS: isolation of acanthamoeba sp. Group II from brain tissue and successful treatment with sulfadiazine and fluconazole. ( 11015431 )
2000
22
Granulomatous amebic encephalitis caused by acanthamoeba. ( 9225325 )
1997
23
Granulomatous amebic encephalitis caused by leptomyxid amebae in an HIV-infected patient. ( 9159368 )
1997
24
Granulomatous amebic encephalitis due to Balamuthia mandrillaris (Leptomyxiidae): report of four cases from Mexico. ( 9230787 )
1997
25
Spontaneous granulomatous amebic encephalitis: report of four cases from Thailand. ( 7855646 )
1994
26
Granulomatous amebic encephalitis: a review and report of a spontaneous case from Venezuela. ( 8017178 )
1994
27
Isolation of Acanthamoeba sp. from a greyhound with pneumonia and granulomatous amebic encephalitis. ( 8373852 )
1993
28
Granulomatous amebic encephalitis in an AIDS patient. ( 1745363 )
1991
29
Granulomatous amebic encephalitis presenting as a cerebral mass lesion. ( 7435149 )
1980

Variations for Granulomatous Amebic Encephalitis

Expression for Granulomatous Amebic Encephalitis

Search GEO for disease gene expression data for Granulomatous Amebic Encephalitis.

Pathways for Granulomatous Amebic Encephalitis

GO Terms for Granulomatous Amebic Encephalitis

Biological processes related to Granulomatous Amebic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 9.16 PHGDH PSAT1
2 biosynthetic process GO:0009058 8.96 ACCS GMPPB
3 L-serine biosynthetic process GO:0006564 8.62 PHGDH PSAT1

Sources for Granulomatous Amebic Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....