MCID: GRN004
MIFTS: 30

Granulomatous Amebic Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Granulomatous Amebic Encephalitis

MalaCards integrated aliases for Granulomatous Amebic Encephalitis:

Name: Granulomatous Amebic Encephalitis 12 52 3 15 71
Granulomatous Amebic Encephalitis Due to Acanthamoeba 12
Acanthamoeba Granulomatous Encephalitis 12
Granulomatous Amoebic Encephalitis 12
Acanthamoeba Encephalitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050246
UMLS 71 C0338428

Summaries for Granulomatous Amebic Encephalitis

NIH Rare Diseases : 52 Granulomatous amebic encephalitis is a life-threatening infection of the brain caused by the free-living amoebae Acanthamoeba spp ., Balamuthia mandrillaris and Sappinia pedata. Acanthamoeba species, are commonly found in lakes, swimming pools, tap water, and heating and air conditioning units. The disease affects immunocompromised peple and is very serious. Symptoms include mental status changes, loss of coordination, fever, muscular weakness or partial paralysis affecting one side of the body, double vision, sensitivity to light and other neurologic problems. The diagnosis is difficult and is often made at advanced stages. Tests useful in the diagnosis include brain scans, biopsies , or spinal taps and in disseminated disease, biopsy of the involved sites and testing by the laboratory experts. Early diagnosis is important for the prognosis . No single drug is effective; hence multiple antibiotics are needed for successful treatment. A combination of surgical and medical interventions involving multiple specialty experts is required to prevent death and morbidity in survivors.

MalaCards based summary : Granulomatous Amebic Encephalitis, also known as granulomatous amebic encephalitis due to acanthamoeba, is related to primary amebic meningoencephalitis and amoebiasis due to free-living amoebae. An important gene associated with Granulomatous Amebic Encephalitis is DCAF8 (DDB1 And CUL4 Associated Factor 8), and among its related pathways/superpathways are Autophagy - animal and Senescence and Autophagy in Cancer. Affiliated tissues include brain, eye and lung.

Disease Ontology : 12 A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

CDC : 3 Acanthamoeba is a microscopic, free-living ameba, or amoeba* (single-celled living organism), that can cause rare**, but severe infections of the eye, skin, and central nervous system. The ameba is found worldwide in the environment in water and soil. The ameba can be spread to the eyes through contact lens use, cuts, or skin wounds or by being inhaled into the lungs. Most people will be exposed to Acanthamoeba during their lifetime, but very few will become sick from this exposure. The three diseases caused by Acanthamoeba are: Acanthamoeba keratitis – An infection of the eye that typically occurs in healthy persons and can result in permanent visual impairment or blindness. Granulomatous Amebic Encephalitis (GAE) – A serious infection of the brain and spinal cord that typically occurs in persons with a compromised immune system. Disseminated infection – A widespread infection that can affect the skin, sinuses, lungs, and other organs independently or in combination. It is also more common in persons with a compromised immune system.

Wikipedia : 74 Granulomatous amoebic encephalitis (GAE) is a rare, usually fatal, subacute-to-chronic central nervous... more...

Related Diseases for Granulomatous Amebic Encephalitis

Graphical network of the top 20 diseases related to Granulomatous Amebic Encephalitis:



Diseases related to Granulomatous Amebic Encephalitis

Symptoms & Phenotypes for Granulomatous Amebic Encephalitis

Drugs & Therapeutics for Granulomatous Amebic Encephalitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Amebic Encephalitis

Genetic Tests for Granulomatous Amebic Encephalitis

Anatomical Context for Granulomatous Amebic Encephalitis

MalaCards organs/tissues related to Granulomatous Amebic Encephalitis:

40
Brain, Eye, Lung, Skin, Testes, Spinal Cord, Kidney

Publications for Granulomatous Amebic Encephalitis

Articles related to Granulomatous Amebic Encephalitis:

(show top 50) (show all 287)
# Title Authors PMID Year
1
Antiamoebic activity of 3-aryl-6,7-dimethoxyquinazolin-4(3H)-one library against Acanthamoeba castellanii. 61
32476058 2020
2
In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites. 61
31939031 2020
3
Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae. 61
32548431 2020
4
Schwann Cell Autophagy and Necrosis as Mechanisms of Cell Death by Acanthamoeba. 61
32526974 2020
5
Metformin-coated silver nanoparticles exhibit anti-acanthamoebic activities against both trophozoite and cyst stages. 61
32461112 2020
6
Isoniazid Conjugated Magnetic Nanoparticles Loaded with Amphotericin B as a Potent Antiamoebic Agent against Acanthamoeba castellanii. 61
32466210 2020
7
Encystment Induces Down-Regulation of an Acetyltransferase-Like Gene in Acanthamoeba castellanii. 61
32357498 2020
8
Acanthamoeba castellanii phosphate transporter (AcPHS) is important to maintain inorganic phosphate influx and is related to trophozoite metabolic processes. 61
31965457 2020
9
Fatal granulomatous amoebic encephalitis due to free-living amoebae in two boys in two different hospitals in Lima, Perú. 61
31758593 2020
10
Balamuthia mandrillaris-Related Primary Amoebic Encephalitis in China Diagnosed by Next Generation Sequencing and a Review of the Literature. 61
31711180 2020
11
A homogeneously enhancing mass evolving into multiple hemorrhagic and necrotic lesions in amoebic encephalitis with necrotizing vasculitis. 61
31864199 2020
12
Acanthamoeba spp. and Balamuthia mandrillaris leading to fatal granulomatous amebic encephalitis. 61
31773473 2020
13
Antioxidant defense in the eyes of immunocompetent and immunosuppressed mice infected with Acanthamoeba spp. 61
32143731 2020
14
Amoebicidal activity of benzothiazole on Acanthamoeba castellanii cysts and trophozoites and its cytotoxic potentials. 61
31887263 2020
15
Acanthamoeba mauritaniensis genotype T4D: An environmental isolate displays pathogenic behavior. 61
31669294 2020
16
Antiamoebic activity of plant-based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492). 61
32016777 2020
17
Molecular detection of free-living amoebae from Namhangang (southern Han River) in Korea. 61
31942007 2020
18
Acanthamoeba and its pathogenic role in granulomatous amebic encephalitis. 61
31647916 2020
19
Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae. 61
31961126 2020
20
"Proposals for Amendments in the Diagnosis and Treatment of Encephalitis caused by Free-living Amoebae". 61
30961516 2020
21
Repositioning of Guanabenz in Conjugation with Gold and Silver Nanoparticles against Pathogenic Amoebae Acanthamoeba castellanii and Naegleria fowleri. 61
31612700 2019
22
Genotyping of Acantamoeba spp. from rhisophere in Hungary. 61
31833382 2019
23
Effects of Shape and Size of Cobalt Phosphate Nanoparticles against Acanthamoeba castellanii. 61
31766722 2019
24
Acanthamoeba in Southeast Asia - Overview and Challenges. 61
31533401 2019
25
Granulomatous amoebic encephalitis caused by Acanthamoeba in a patient with AIDS: a challenging diagnosis. 61
31455179 2019
26
Evaluation of Oxasqualenoids from the Red Alga Laurencia viridis against Acanthamoeba. 61
31331002 2019
27
Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini. 61
31069536 2019
28
Cobalt nanoparticles as novel nanotherapeutics against Acanthamoeba castellanii. 61
31159839 2019
29
Antidiabetic Drugs and Their Nanoconjugates Repurposed as Novel Antimicrobial Agents against Acanthamoeba castellanii. 61
31030451 2019
30
Evidence of human-like Ca2+ channels and effects of Ca2+ channel blockers in Acanthamoeba castellanii. 61
30362253 2019
31
Evaluation of the sensitivity to chlorhexidine, voriconazole and itraconazole of T4 genotype Acanthamoeba isolated from Mexico. 61
30648558 2019
32
Fatal Balamuthia mandrillaris Encephalitis. 61
30838148 2019
33
Innovative Methodology in the Discovery of Novel Drug Targets in the Free-Living Amoebae. 61
29697029 2019
34
Identification and Genotypic Characterization of Potentially Pathogenic Acanthamoeba Isolated from Tap Water in Wuxi, China. 61
30630284 2018
35
Comparison of Proteins Secreted into Extracellular Space of Pathogenic and Non-pathogenic Acanthamoeba castellanii. 61
30630275 2018
36
Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii. 61
30477573 2018
37
Fatal Granulomatous Amebic Encephalitis in a Heart Transplant Patient: Clinical, Radiographic, and Autopsy Findings. 61
30295806 2018
38
Genotyping of Acanthamoeba spp. isolated from patients with granulomatous amoebic encephalitis. 61
30666010 2018
39
Isolation and molecular identification of Acanthamoeba spp. from hot springs in Mazandaran province, northern Iran. 61
30285961 2018
40
DNA extraction from amoebal isolates and genotype determination of Acanthamoeba from tap water in Latvia. 61
29978422 2018
41
Comparative proteomic analysis of soluble and surface-enriched proteins from Acanthamoeba castellanii trophozoites. 61
30205118 2018
42
Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris. 61
30377287 2018
43
First report of the isolation of Balamuthia mandrillaris in the northern region of Japan. 61
29961176 2018
44
Balamuthia mandrillaris Granulomatous Amebic Encephalitis With Renal Dissemination in a Previously Healthy Child: Case Report and Review of the Pediatric Literature. 61
29096002 2018
45
[Isolation of Balamuthia mandriallaris parasite from air conditioning of the houses in south and southeast of Turkey]. 61
30156514 2018
46
An Acute Case of Granulomatous Amoebic Encephalitis-Balamuthia mandrillaris Infection. 61
29321406 2018
47
A case report of granulomatous amoebic encephalitis by Group 1 Acanthamoeba genotype T18 diagnosed by the combination of morphological examination and genetic analysis. 61
29747695 2018
48
Apoptosis of Acanthamoeba castellanii Trophozoites Induced by Oleic Acid. 61
28787535 2018
49
Application of modified JDP-DGGE-based molecular genotyping method to predict Acanthamoeba genotype and to analyse community diversity in aquatic environments. 61
29248979 2018
50
Occurrence of Acanthamoeba genotypes in Central West Malaysian environments. 61
29203378 2018

Variations for Granulomatous Amebic Encephalitis

Expression for Granulomatous Amebic Encephalitis

Search GEO for disease gene expression data for Granulomatous Amebic Encephalitis.

Pathways for Granulomatous Amebic Encephalitis

Pathways related to Granulomatous Amebic Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.47 GABARAPL2 GABARAPL1 ATG3
2 11.16 GABARAPL2 GABARAPL1 ATG3
3
Show member pathways
10.79 GABARAPL2 GABARAPL1 ATG3

GO Terms for Granulomatous Amebic Encephalitis

Cellular components related to Granulomatous Amebic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagosome membrane GO:0000421 8.62 GABARAPL2 GABARAPL1

Biological processes related to Granulomatous Amebic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 autophagy GO:0006914 9.5 GABARAPL2 GABARAPL1 ATG3
2 autophagosome maturation GO:0097352 9.37 GABARAPL2 GABARAPL1
3 macroautophagy GO:0016236 9.33 GABARAPL2 GABARAPL1 ATG3
4 cellular response to nitrogen starvation GO:0006995 9.26 GABARAPL2 GABARAPL1
5 autophagosome assembly GO:0000045 9.13 GABARAPL2 GABARAPL1 ATG3
6 autophagy of mitochondrion GO:0000422 8.8 GABARAPL2 GABARAPL1 ATG3

Molecular functions related to Granulomatous Amebic Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ubiquitin protein ligase binding GO:0031625 9.33 HM13 GABARAPL2 GABARAPL1
2 beta-tubulin binding GO:0048487 8.96 GABARAPL2 GABARAPL1
3 GABA receptor binding GO:0050811 8.62 GABARAPL2 GABARAPL1

Sources for Granulomatous Amebic Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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