MCID: GRN006
MIFTS: 30

Granulomatous Angiitis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Granulomatous Angiitis

MalaCards integrated aliases for Granulomatous Angiitis:

Name: Granulomatous Angiitis 12 15 71
Vasculitis, Central Nervous System 43

Classifications:



External Ids:

Disease Ontology 12 DOID:2555
MeSH 43 D020293
NCIt 49 C34653
UMLS 71 C0018202

Summaries for Granulomatous Angiitis

MalaCards based summary : Granulomatous Angiitis, also known as vasculitis, central nervous system, is related to mononeuritis multiplex and central nervous system vasculitis. An important gene associated with Granulomatous Angiitis is IL5 (Interleukin 5). The drugs Carmustine and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and colon.

Related Diseases for Granulomatous Angiitis

Diseases related to Granulomatous Angiitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 mononeuritis multiplex 30.7 PRTN3 CRP
2 central nervous system vasculitis 30.4 PRTN3 CRP
3 chronic meningitis 30.3 IL5 CRP
4 neurosarcoidosis 30.3 CRP ACE
5 central retinal artery occlusion 30.2 PRTN3 CRP
6 retinal artery occlusion 30.0 CRP ACE
7 granulomatosis with polyangiitis 30.0 PRTN3 IL5 CRP
8 cranial nerve palsy 30.0 PRTN3 CRP ACE
9 papilledema 29.9 CRP ACE
10 exanthem 29.7 PRTN3 CRP ACE
11 peripheral nervous system disease 29.5 PRTN3 MBP CRP ACE
12 polyneuropathy 29.5 MBP CRP ACE
13 optic nerve disease 29.3 MBP CRP ACE
14 autoimmune disease 29.3 PRTN3 MBP IL5 CRP
15 churg-strauss syndrome 11.8
16 primary angiitis of the central nervous system 11.8
17 vasculitis 10.7
18 allergic angiitis 10.6
19 hypereosinophilic syndrome 10.5
20 herpes zoster 10.5
21 polyarteritis nodosa 10.4
22 cerebral amyloid angiopathy, cst3-related 10.3
23 sarcoidosis 1 10.3
24 chickenpox 10.3
25 neuropathy 10.3
26 mikulicz disease 10.3 IL5 CRP
27 orbital granuloma 10.3 PRTN3 CRP
28 anterior scleritis 10.3 PRTN3 CRP
29 ethmoid sinusitis 10.3 PRTN3 CRP
30 orbital plasma cell granuloma 10.3 PRTN3 CRP
31 bicipital tenosynovitis 10.3 PRTN3 CRP
32 tenosynovitis 10.3 PRTN3 CRP
33 chronic orbital inflammation 10.3 PRTN3 CRP
34 toxocariasis 10.3 IL5 CRP
35 glossopharyngeal nerve disease 10.3 PRTN3 CRP
36 cogan syndrome 10.3 PRTN3 CRP
37 mononeuritis of upper limb and mononeuritis multiplex 10.3 PRTN3 CRP
38 subacute bacterial endocarditis 10.3 PRTN3 CRP
39 aortitis 10.3 PRTN3 CRP
40 splenic infarction 10.3 PRTN3 CRP
41 mastoiditis 10.3 PRTN3 CRP
42 wells syndrome 10.3 IL5 CRP
43 chondromalacia 10.2 PRTN3 CRP
44 maxillary sinusitis 10.2 PRTN3 CRP
45 pyuria 10.2 PRTN3 CRP
46 cough variant asthma 10.2 IL5 ACE
47 lung abscess 10.2 PRTN3 CRP
48 granulomatous myositis 10.2 PRTN3 ACE
49 cryptogenic organizing pneumonia 10.2 PRTN3 CRP
50 autoimmune vasculitis 10.2 PRTN3 CRP

Graphical network of the top 20 diseases related to Granulomatous Angiitis:



Diseases related to Granulomatous Angiitis

Symptoms & Phenotypes for Granulomatous Angiitis

Drugs & Therapeutics for Granulomatous Angiitis

Drugs for Granulomatous Angiitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved, Investigational Phase 2 154-93-8 2578
2
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
5
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
6
Melphalan Approved Phase 2 148-82-3 460612 4053
7
Phenylalanine Approved, Investigational, Nutraceutical Phase 2 63-91-2 6140
8
Cortisone Experimental Phase 2 53-06-5 222786
9 Antibodies Phase 1, Phase 2
10 Antibodies, Monoclonal Phase 1, Phase 2
11 Immunoglobulins Phase 1, Phase 2
12 Immunologic Factors Phase 2
13 Etoposide phosphate Phase 2
14 Hormones Phase 2
15 glucocorticoids Phase 2
16 Antineoplastic Agents, Hormonal Phase 2
17 Immunosuppressive Agents Phase 2
18 Anti-Infective Agents Phase 2
19 Nitrogen Mustard Compounds Phase 2
20 Alkylating Agents Phase 2
21 Hormone Antagonists Phase 2
22 Dermatologic Agents Phase 2
23 Antiviral Agents Phase 2
24 Thymoglobulin Phase 2
25 Podophyllotoxin Phase 2 518-28-5
26 Tubulin Modulators Phase 2
27 Keratolytic Agents Phase 2
28 Antimetabolites Phase 2
29 Antimitotic Agents Phase 2
30 Antilymphocyte Serum Phase 2
31 Anti-Inflammatory Agents Phase 2
32
L-Alanine Nutraceutical Phase 2 56-41-7 5950
33
Glutamic acid Approved, Nutraceutical 56-86-0 33032

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Phase Ib Study of Milatuzumab Administered Subcutaneously in Patients With Active Systemic Lupus Erythematosus (SLE) Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
2 High-Dose Immunosuppressive Therapy Using Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) + Thymoglobulin Followed by Syngeneic or Autologous Hematopoietic Cell Transplantation for Patients With Autoimmune Neurologic Diseases Recruiting NCT00716066 Phase 2 Carmustine;Cytarabine;Etoposide;Melphalan;Prednisone
3 Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes Unknown status NCT02006134
4 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
5 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
6 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
7 Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis Completed NCT03595761
8 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
9 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
10 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
11 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
12 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
13 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
14 High Resolution Vessel Wall Imaging by Magnetic Resonance Imaging of Intracranial Vasculopathies Recruiting NCT03032809
15 The Utility of Intracranial Vessel Wall Imaging for Suspected CNS Vasculitis Diagnosis and Assessment of Disease Activity. Active, not recruiting NCT03166319
16 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Active, not recruiting NCT02456168

Search NIH Clinical Center for Granulomatous Angiitis

Cochrane evidence based reviews: vasculitis, central nervous system

Genetic Tests for Granulomatous Angiitis

Anatomical Context for Granulomatous Angiitis

MalaCards organs/tissues related to Granulomatous Angiitis:

40
Brain, Spinal Cord, Colon, Small Intestine, Lung, Pituitary, Cerebellum

Publications for Granulomatous Angiitis

Articles related to Granulomatous Angiitis:

(show top 50) (show all 292)
# Title Authors PMID Year
1
The leukotriene receptor antagonist Montelukast can induce adverse skin reactions in asthmatic patients. 61
31837440 2020
2
Cerebral amyloid-β-related angiitis without cerebral microbleeds in a patient with subarachnoid hemorrhage. 61
31226598 2019
3
Granulomatous Angiitis: Twenty Years Later. 61
30952409 2019
4
Formation and Disordered Degradation of Neutrophil Extracellular Traps in Necrotizing Lesions of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
30677396 2019
5
Necrotizing Sarcoid Granulomatosis with Natural Resolution after a Surgical Lung Biopsy. 61
29321436 2018
6
Granulomatous Angiitis of the Central Nervous System Associated with Hodgkin's Lymphoma: Case Report and Literature Review. 61
28943218 2018
7
Adverse drug reactions of montelukast in children and adults. 61
28971612 2017
8
Amyloid-β-related angiitis: a report of 2 cases with unusual presentations. 61
28161339 2017
9
[TREATMENT DILEMMAS IN BEHÇET'S SYNDROME]. 61
27215119 2016
10
Foreign Body Emboli following Cerebrovascular Interventions: Clinical, Radiographic, and Histopathologic Features. 61
26294650 2015
11
Primary angiitis of central nervous system: The story of a great masquerader. 61
26167025 2015
12
Primary granulomatous angiitis of the central nervous system with amyloid angiopathy: a case report and literature review. 61
25692513 2015
13
Small bowel involvement documented by capsule endoscopy in Churg-Strauss syndrome. 61
26664542 2015
14
Posterior reversible leukoencephalopathy syndrome as a presenting manifestation of p-ANCA-associated vasculitis. 61
24855074 2014
15
Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. 61
24705493 2014
16
Rapidly progressive dementia due to neurosarcoidosis. 61
29213869 2013
17
Primary granulomatous angiitis of the CNS preferentially involving small veins with a granulomatous leukoencephalitis-like lesion in the cerebrum. 61
23279573 2013
18
Churg-Strauss syndrome: a case report. 61
23984622 2013
19
Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma. 61
23269593 2013
20
Strategy of Infection Control in Immunosuppressive Therapy for ANCA-Associated Vasculitis. 61
23641277 2013
21
A remarkable pattern of subcortical vessel wall enhancement in granulomatous angiitis of the central nervous system. 61
23028033 2012
22
Effective intravenous immunoglobulin therapy for Churg-Strauss syndrome (allergic granulomatous angiitis) complicated by neuropathy of the eighth cranial nerve: a case report. 61
22989316 2012
23
Central and peripheral neurological complications of primary Sjögren's syndrome. 61
22840992 2012
24
Sarcoidosis in a young child with Alagille syndrome: a case report. 61
22937766 2012
25
Churg Strauss syndrome associated with montelukast--case report. 61
22783603 2012
26
Teaching NeuroImages: granulomatous angiitis of the CNS associated with Hodgkin lymphoma. 61
22067969 2011
27
[Allergic granulomatous angiitis (Churg-Strauss syndrome)]. 61
21399394 2011
28
Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist. 61
20607580 2010
29
[An autopsy case of senile dementia suspected to be influenced by cerebral amyloid angiopathy with multiple cortical microinfarcts]. 61
20960931 2010
30
An abdominal presentation of churg-strauss syndrome. 61
20814555 2010
31
Complete unilateral ophthalmoplegia in herpes zoster ophthalmicus. 61
19952908 2009
32
[Churg-Strauss syndrome presenting with cutaneous vasculitis]. 61
19569284 2009
33
Granulomatous angiitis leading to a pulmonary veno-occlusive disease-like picture. 61
19251802 2009
34
Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. 61
19253257 2009
35
Correlation between Helicobacter pylori infection and pulmonary Wegener's granulomacytosis activity. 61
19218713 2008
36
[Classification of systemic vasculitides]. 61
18524103 2008
37
Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery. Case report. 61
17937238 2007
38
ANCA-associated vasculitis: diagnostic and therapeutic strategy. 61
17460438 2007
39
Primary angiitis of the central nervous system. 61
17445494 2007
40
[Granulomatous angiitis of the CNS associated with cerebral amyloid angiopathy--an autopsied case with widespread involvement]. 61
17533981 2007
41
Wegener's granulomatosis in New Zealand: evidence for a latitude-dependent incidence gradient. 61
17388864 2007
42
Osler and the Churg-Strauss syndrome. 61
17218770 2007
43
Head and neck manifestations of Wegener's granulomatosis. 61
17216737 2006
44
Relapsing granulomatous angiitis of the central nervous system in a patient while in remission from Hodgkin lymphoma. 61
17144241 2006
45
Reversible posterior leukoencephalopathy syndrome in p-ANCA-associated vasculitis. 61
17106164 2006
46
Nontraumatic pseudoaneurysm of the proximal ulnar artery with eosinophilia. 61
16376222 2005
47
Initial cutaneous manifestations consistent with mononeuropathy multiplex in Churg-Strauss syndrome. 61
16027304 2005
48
Ileal ulcers and cytomegalovirus infection in a case of Churg-Strauss syndrome. 61
15913442 2005
49
Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy. 61
15659428 2005
50
Concurrent occurrence of allergic granulomatous angiitis and temporal arteritis: a case report and review of the literature. 61
17029049 2005

Variations for Granulomatous Angiitis

Expression for Granulomatous Angiitis

Search GEO for disease gene expression data for Granulomatous Angiitis.

Pathways for Granulomatous Angiitis

GO Terms for Granulomatous Angiitis

Biological processes related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein tyrosine kinase activity GO:0061098 8.62 GRM5 ACE

Sources for Granulomatous Angiitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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