MCID: GRN006
MIFTS: 34

Granulomatous Angiitis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Granulomatous Angiitis

MalaCards integrated aliases for Granulomatous Angiitis:

Name: Granulomatous Angiitis 12 15 71
Vasculitis, Central Nervous System 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2555
MeSH 44 D020293
NCIt 50 C34653
UMLS 71 C0018202

Summaries for Granulomatous Angiitis

MalaCards based summary : Granulomatous Angiitis, also known as vasculitis, central nervous system, is related to churg-strauss syndrome and polyarteritis nodosa. An important gene associated with Granulomatous Angiitis is IL5 (Interleukin 5), and among its related pathways/superpathways are Butanoate metabolism and Amino Acid conjugation. The drugs Melphalan and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and small intestine.

Related Diseases for Granulomatous Angiitis

Diseases related to Granulomatous Angiitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 32.0 PRTN3 IL5
2 polyarteritis nodosa 30.5 PRTN3 CRP
3 central nervous system vasculitis 30.3 PRTN3 CRP
4 neurosarcoidosis 30.3 CRP ACE
5 branch retinal artery occlusion 30.2 PRTN3 CRP
6 chronic meningitis 30.2 IL5 CRP
7 central retinal artery occlusion 30.1 PRTN3 CRP
8 cranial nerve palsy 30.1 PRTN3 CRP ACE
9 retinal artery occlusion 30.1 CRP ACE
10 pericardial effusion 30.1 PRTN3 CRP ACE
11 mononeuritis multiplex 30.1 PRTN3 IL5 CRP ACE
12 papilledema 30.0 CRP ACE
13 granulomatosis with polyangiitis 29.9 PRTN3 IL5 CRP
14 polyneuropathy 29.9 MBP CRP ACE
15 exanthem 29.9 PRTN3 CRP ACE
16 pneumonia 29.8 IL5 CRP ACE
17 optic nerve disease 29.7 MBP CRP ACE
18 autoimmune disease 29.5 PRTN3 MBP IL5 CRP
19 respiratory failure 29.4 IL5 CRP ACE
20 primary angiitis of the central nervous system 11.2
21 allergic angiitis 10.6
22 vasculitis 10.6
23 hypereosinophilic syndrome 10.5
24 herpes zoster 10.5
25 cerebral amyloid angiopathy, cst3-related 10.3
26 sarcoidosis 1 10.3
27 chickenpox 10.3
28 neuropathy 10.3
29 bagassosis 10.3 PRTN3 IL5
30 cough variant asthma 10.3 IL5 ACE
31 granulomatous myositis 10.3 PRTN3 ACE
32 peripheral nervous system disease 10.2
33 purulent acute otitis media 10.2 PRTN3 CRP
34 mikulicz disease 10.2 IL5 CRP
35 frontal sinusitis 10.2 PRTN3 CRP
36 orbital plasma cell granuloma 10.2 PRTN3 CRP
37 bicipital tenosynovitis 10.2 PRTN3 CRP
38 tenosynovitis 10.2 PRTN3 CRP
39 ethmoid sinusitis 10.2 PRTN3 CRP
40 acute dacryocystitis 10.2 PRTN3 ACE
41 splenic tuberculosis 10.2 PRTN3 CRP
42 subacute bacterial endocarditis 10.2 PRTN3 CRP
43 mastoiditis 10.2 PRTN3 CRP
44 cogan syndrome 10.2 PRTN3 CRP
45 toxocariasis 10.2 IL5 CRP
46 aortitis 10.2 PRTN3 CRP
47 chondromalacia 10.2 PRTN3 CRP
48 lung abscess 10.2 PRTN3 CRP
49 parametritis 10.2 IL5 CRP
50 splenic infarction 10.2 PRTN3 CRP

Graphical network of the top 20 diseases related to Granulomatous Angiitis:



Diseases related to Granulomatous Angiitis

Symptoms & Phenotypes for Granulomatous Angiitis

Drugs & Therapeutics for Granulomatous Angiitis

Drugs for Granulomatous Angiitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 2 148-82-3 4053 460612
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Carmustine Approved, Investigational Phase 2 154-93-8 2578
4
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
5
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
6
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
7
Phenylalanine Approved, Investigational, Nutraceutical Phase 2 63-91-2 6140
8
Cortisone Experimental Phase 2 53-06-5 222786
9 Immunoglobulins Phase 1, Phase 2
10 Antibodies Phase 1, Phase 2
11 Antibodies, Monoclonal Phase 1, Phase 2
12 Immunologic Factors Phase 2
13 Keratolytic Agents Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Etoposide phosphate Phase 2
16 Antimitotic Agents Phase 2
17 Hormone Antagonists Phase 2
18 glucocorticoids Phase 2
19 Hormones Phase 2
20 Antilymphocyte Serum Phase 2
21 Anti-Infective Agents Phase 2
22 Antimetabolites Phase 2
23 Thymoglobulin Phase 2
24 Antiviral Agents Phase 2
25 Nitrogen Mustard Compounds Phase 2
26 Dermatologic Agents Phase 2
27 Antineoplastic Agents, Hormonal Phase 2
28 Tubulin Modulators Phase 2
29 Podophyllotoxin Phase 2 518-28-5
30 Immunosuppressive Agents Phase 2
31 Alkylating Agents Phase 2
32
L-Alanine Nutraceutical Phase 2 56-41-7 5950
33
Glutamic acid Approved, Nutraceutical 56-86-0 33032

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Phase Ib Study of Milatuzumab Administered Subcutaneously in Patients With Active Systemic Lupus Erythematosus (SLE) Completed NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
2 High-Dose Immunosuppressive Therapy Using Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) + Thymoglobulin Followed by Syngeneic or Autologous Hematopoietic Cell Transplantation for Patients With Autoimmune Neurologic Diseases Recruiting NCT00716066 Phase 2 Carmustine;Cytarabine;Etoposide;Melphalan;Prednisone
3 High Resolution Vessel Wall Imaging by Magnetic Resonance Imaging of Intracranial Vasculopathies Unknown status NCT03032809
4 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
5 Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis Completed NCT03595761
6 Magnetic Resonance Spectroscopy, Perfusion, and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00730002
7 Magnetic Resonance Spectroscopy, Perfusion and Diffusion Tensor Imaging in Neuropsychiatric Lupus Completed NCT00723671
8 Libman-Sacks Endocarditis as a Cause of Neuropsychiatric Systemic Lupus Erythematosus Completed NCT00858884
9 Illness Perception, Fatigue, and Function in Systemic Vasculitis (The VCRC Vasculitis Perception (VIP) Study) Completed NCT02190916
10 The Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
11 Educational Needs of Patients With Systemic Vasculitis- an International Survey Completed NCT02190929
12 Impact of Vasculitis on Employment and Income. An Online Survey of Participants in the VCRC Patient Contact Registry Completed NCT02476292
13 Chronic Childhood Vasculitis: Characterizing the Individual Rare Diseases to Improve Patient Outcomes Recruiting NCT02006134
14 The Vasculitis Pregnancy Registry (V-PREG) Recruiting NCT02593565
15 The Utility of Intracranial Vessel Wall Imaging for Suspected CNS Vasculitis Diagnosis and Assessment of Disease Activity. Active, not recruiting NCT03166319
16 Development of a Novel Glutamate Receptor Ligand for PET Scans in Neuropsychiatric Systemic Lupus Erythematosus Active, not recruiting NCT02456168

Search NIH Clinical Center for Granulomatous Angiitis

Cochrane evidence based reviews: vasculitis, central nervous system

Genetic Tests for Granulomatous Angiitis

Anatomical Context for Granulomatous Angiitis

MalaCards organs/tissues related to Granulomatous Angiitis:

40
Spinal Cord, Brain, Small Intestine, Pituitary, Neutrophil, Cerebellum, Colon

Publications for Granulomatous Angiitis

Articles related to Granulomatous Angiitis:

(show top 50) (show all 289)
# Title Authors PMID Year
1
Limited granulomatosis with polyangiitis presenting as an isolated lung lesion. 61
33154316 2020
2
The leukotriene receptor antagonist Montelukast can induce adverse skin reactions in asthmatic patients. 61
31837440 2020
3
Cerebral amyloid-β-related angiitis without cerebral microbleeds in a patient with subarachnoid hemorrhage. 61
31226598 2019
4
Granulomatous Angiitis: Twenty Years Later. 61
30952409 2019
5
Formation and Disordered Degradation of Neutrophil Extracellular Traps in Necrotizing Lesions of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
30677396 2019
6
Necrotizing Sarcoid Granulomatosis with Natural Resolution after a Surgical Lung Biopsy. 61
29321436 2018
7
Granulomatous Angiitis of the Central Nervous System Associated with Hodgkin's Lymphoma: Case Report and Literature Review. 61
28943218 2018
8
Adverse drug reactions of montelukast in children and adults. 61
28971612 2017
9
Amyloid-β-related angiitis: a report of 2 cases with unusual presentations. 61
28161339 2017
10
[TREATMENT DILEMMAS IN BEHÇET'S SYNDROME]. 61
27215119 2016
11
Foreign Body Emboli following Cerebrovascular Interventions: Clinical, Radiographic, and Histopathologic Features. 61
26294650 2015
12
Primary angiitis of central nervous system: The story of a great masquerader. 61
26167025 2015
13
Primary granulomatous angiitis of the central nervous system with amyloid angiopathy: a case report and literature review. 61
25692513 2015
14
Small bowel involvement documented by capsule endoscopy in Churg-Strauss syndrome. 61
26664542 2015
15
Posterior reversible leukoencephalopathy syndrome as a presenting manifestation of p-ANCA-associated vasculitis. 61
24855074 2014
16
Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas. 61
24705493 2014
17
Primary granulomatous angiitis of the CNS preferentially involving small veins with a granulomatous leukoencephalitis-like lesion in the cerebrum. 61
23279573 2013
18
Rapidly progressive dementia due to neurosarcoidosis. 61
29213869 2013
19
Churg-Strauss syndrome: a case report. 61
23984622 2013
20
Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma. 61
23269593 2013
21
Strategy of Infection Control in Immunosuppressive Therapy for ANCA-Associated Vasculitis. 61
23641277 2013
22
A remarkable pattern of subcortical vessel wall enhancement in granulomatous angiitis of the central nervous system. 61
23028033 2012
23
Central and peripheral neurological complications of primary Sjögren's syndrome. 61
22840992 2012
24
Effective intravenous immunoglobulin therapy for Churg-Strauss syndrome (allergic granulomatous angiitis) complicated by neuropathy of the eighth cranial nerve: a case report. 61
22989316 2012
25
Sarcoidosis in a young child with Alagille syndrome: a case report. 61
22937766 2012
26
Churg Strauss syndrome associated with montelukast--case report. 61
22783603 2012
27
Teaching NeuroImages: granulomatous angiitis of the CNS associated with Hodgkin lymphoma. 61
22067969 2011
28
[Allergic granulomatous angiitis (Churg-Strauss syndrome)]. 61
21399394 2011
29
Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist. 61
20607580 2010
30
[An autopsy case of senile dementia suspected to be influenced by cerebral amyloid angiopathy with multiple cortical microinfarcts]. 61
20960931 2010
31
An abdominal presentation of churg-strauss syndrome. 61
20814555 2010
32
Complete unilateral ophthalmoplegia in herpes zoster ophthalmicus. 61
19952908 2009
33
[Churg-Strauss syndrome presenting with cutaneous vasculitis]. 61
19569284 2009
34
Granulomatous angiitis leading to a pulmonary veno-occlusive disease-like picture. 61
19251802 2009
35
Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. 61
19253257 2009
36
Correlation between Helicobacter pylori infection and pulmonary Wegener's granulomacytosis activity. 61
19218713 2008
37
[Classification of systemic vasculitides]. 61
18524103 2008
38
Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery. Case report. 61
17937238 2007
39
ANCA-associated vasculitis: diagnostic and therapeutic strategy. 61
17460438 2007
40
Primary angiitis of the central nervous system. 61
17445494 2007
41
[Granulomatous angiitis of the CNS associated with cerebral amyloid angiopathy--an autopsied case with widespread involvement]. 61
17533981 2007
42
Wegener's granulomatosis in New Zealand: evidence for a latitude-dependent incidence gradient. 61
17388864 2007
43
Osler and the Churg-Strauss syndrome. 61
17218770 2007
44
Head and neck manifestations of Wegener's granulomatosis. 61
17216737 2006
45
Relapsing granulomatous angiitis of the central nervous system in a patient while in remission from Hodgkin lymphoma. 61
17144241 2006
46
Reversible posterior leukoencephalopathy syndrome in p-ANCA-associated vasculitis. 61
17106164 2006
47
Nontraumatic pseudoaneurysm of the proximal ulnar artery with eosinophilia. 61
16376222 2005
48
Initial cutaneous manifestations consistent with mononeuropathy multiplex in Churg-Strauss syndrome. 61
16027304 2005
49
Ileal ulcers and cytomegalovirus infection in a case of Churg-Strauss syndrome. 61
15913442 2005
50
Abeta-related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy. 61
15659428 2005

Variations for Granulomatous Angiitis

Expression for Granulomatous Angiitis

Search GEO for disease gene expression data for Granulomatous Angiitis.

Pathways for Granulomatous Angiitis

Pathways related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.54 ACSM2B ACSM2A
2
Show member pathways
10.2 ACSM2B ACSM2A

GO Terms for Granulomatous Angiitis

Biological processes related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein tyrosine kinase activity GO:0061098 9.16 GRM5 ACE
2 acyl-CoA metabolic process GO:0006637 8.96 ACSM2B ACSM2A
3 long-chain fatty acid metabolic process GO:0001676 8.62 ACSM2B ACSM2A

Molecular functions related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 long-chain fatty acid-CoA ligase activity GO:0004467 9.37 ACSM2B ACSM2A
2 butyrate-CoA ligase activity GO:0047760 9.32 ACSM2B ACSM2A
3 fatty acid ligase activity GO:0015645 9.26 ACSM2B ACSM2A
4 fatty-acyl-CoA synthase activity GO:0004321 9.16 ACSM2B ACSM2A
5 medium-chain fatty acid-CoA ligase activity GO:0031956 8.96 ACSM2B ACSM2A
6 benzoate-CoA ligase activity GO:0018858 8.62 ACSM2B ACSM2A

Sources for Granulomatous Angiitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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