MCID: GRN006
MIFTS: 36

Granulomatous Angiitis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Granulomatous Angiitis

MalaCards integrated aliases for Granulomatous Angiitis:

Name: Granulomatous Angiitis 12 15 73
Vasculitis, Central Nervous System 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2555
MeSH 44 D020293
NCIt 50 C34653
UMLS 73 C0018202

Summaries for Granulomatous Angiitis

MalaCards based summary : Granulomatous Angiitis, also known as vasculitis, central nervous system, is related to churg-strauss syndrome and chronic meningitis. An important gene associated with Granulomatous Angiitis is IL5 (Interleukin 5), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, spinal cord and colon, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Granulomatous Angiitis

Diseases related to Granulomatous Angiitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 32.4 IL5 PRTN3 THBD
2 chronic meningitis 30.1 CRP IL5
3 nervous system disease 29.8 ACE CRP MBP
4 vasculitis 29.7 CRP PRTN3 THBD
5 central nervous system vasculitis 11.9
6 primary angiitis of the central nervous system 11.3
7 allergic angiitis 10.5
8 herpes zoster 10.3
9 lymphoma 10.2
10 neuropathy 10.2
11 oculomotor nerve paralysis 10.2 AVP MBP
12 third cranial nerve disease 10.2 AVP MBP
13 central pontine myelinolysis 10.2 AVP MBP
14 generalized atherosclerosis 10.1 ACE CRP
15 cerebral amyloid angiopathy, cst3-related 10.1
16 lymphoma, hodgkin, classic 10.1
17 herpes zoster ophthalmicus 10.1
18 bronchus cancer 10.1 AVP CRP
19 paralytic ileus 10.1 AVP CRP
20 bronchiolitis 10.1 CRP IL5 MUC5B
21 vascular dementia 10.1 ACE CST3 MBP
22 lymphohistiocytoid mesothelioma 10.1 CD68 THBD
23 pyomyositis 10.1 CRP NOTCH1
24 respiratory system disease 10.1 CRP IL5 MUC5B
25 subclavian steal syndrome 10.1 CRP NOTCH1
26 fiedler's myocarditis 10.1 ACE CD68
27 nodular regenerative hyperplasia 10.1 JAG1 NOTCH1
28 subdural empyema 10.1 ACE CRP MUC5B
29 dental abscess 10.1 AVP CRP
30 systolic heart failure 10.1 ACE CRP CST3
31 carotid artery disease 10.1 ACE CRP THBD
32 peripheral vascular disease 10.1 ACE CRP THBD
33 peripheral artery disease 10.1 ACE CRP CST3
34 pneumonia 10.1 CRP IL5 MUC5B
35 peripheral nervous system disease 10.1
36 meningitis 10.1
37 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.0 EGF JAG1 NOTCH1
38 end stage renal failure 10.0 ACE CRP CST3
39 respiratory failure 10.0 ACE CRP SLC4A1
40 pericoronitis 10.0 CD68 CRP
41 aortic aneurysm, familial abdominal, 1 10.0 ACE CRP CST3
42 sphenoid sinusitis 10.0 AVP CRP
43 petroclival meningioma 10.0 CD68 NOTCH1
44 aortic valve disease 1 10.0 ACE CRP NOTCH1
45 xanthogranulomatous pyelonephritis 10.0 CD68 CRP EGF
46 autosomal dominant polycystic kidney disease 10.0 ACE AVP CST3 EGF
47 vascular disease 9.9 ACE CRP CST3 THBD
48 hypertension, essential 9.9 ACE CRP CST3 THBD
49 ethmoid sinusitis 9.9 CRP MUC5B PRTN3
50 temporal arteritis 9.9

Graphical network of the top 20 diseases related to Granulomatous Angiitis:



Diseases related to Granulomatous Angiitis

Symptoms & Phenotypes for Granulomatous Angiitis

GenomeRNAi Phenotypes related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.72 CRP CST3 HYLS1 NOTCH1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.72 HYLS1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.72 NOTCH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.72 CRP HYLS1 NOTCH1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.72 CRP NOTCH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.72 CST3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.72 CST3 HYLS1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.72 NOTCH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.72 CST3 NOTCH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.72 CRP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.72 HYLS1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.72 NOTCH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 CRP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.72 HYLS1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.72 NOTCH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.72 CST3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 HYLS1

MGI Mouse Phenotypes related to Granulomatous Angiitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 ACE CD68 IL5 JAG1 MBP MUC5B
2 homeostasis/metabolism MP:0005376 9.73 ABRA ACE AVP CRP CST3 IL5
3 immune system MP:0005387 9.36 ACE CD68 CRP EGF IL5 MBP

Drugs & Therapeutics for Granulomatous Angiitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290

Search NIH Clinical Center for Granulomatous Angiitis

Cochrane evidence based reviews: vasculitis, central nervous system

Genetic Tests for Granulomatous Angiitis

Anatomical Context for Granulomatous Angiitis

MalaCards organs/tissues related to Granulomatous Angiitis:

41
Brain, Spinal Cord, Colon, Small Intestine, Lung, Kidney, Heart

Publications for Granulomatous Angiitis

Articles related to Granulomatous Angiitis:

(show top 50) (show all 116)
# Title Authors Year
1
Granulomatous Angiitis of the Central Nervous System Associated with Hodgkin's Lymphoma: Case Report and Literature Review. ( 28943218 )
2017
2
Primary granulomatous angiitis of the central nervous system with amyloid angiopathy: a case report and literature review. ( 25692513 )
2015
3
Primary granulomatous angiitis of the CNS preferentially involving small veins with a granulomatous leukoencephalitis-like lesion in the cerebrum. ( 23279573 )
2013
4
Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma. ( 23269593 )
2013
5
Effective intravenous immunoglobulin therapy for Churg-Strauss syndrome (allergic granulomatous angiitis) complicated by neuropathy of the eighth cranial nerve: a case report. ( 22989316 )
2012
6
A remarkable pattern of subcortical vessel wall enhancement in granulomatous angiitis of the central nervous system. ( 23028033 )
2012
7
Teaching NeuroImages: granulomatous angiitis of the CNS associated with Hodgkin lymphoma. ( 22067969 )
2011
8
Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist. ( 20607580 )
2010
9
Granulomatous angiitis leading to a pulmonary veno-occlusive disease-like picture. ( 19251802 )
2009
10
Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. ( 19253257 )
2009
11
Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery. Case report. ( 17937238 )
2007
12
Relapsing granulomatous angiitis of the central nervous system in a patient while in remission from Hodgkin lymphoma. ( 17144241 )
2006
13
Concurrent occurrence of allergic granulomatous angiitis and temporal arteritis: a case report and review of the literature. ( 17029049 )
2005
14
Churg-Strauss syndrome (allergic granulomatous angiitis) associated with T lymphoblastic lymphoma. ( 15369188 )
2004
15
Granulomatous angiitis of the central nervous system revealing Hodgkin's disease. ( 15164198 )
2004
16
The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. ( 14625818 )
2003
17
Hodgkins disease presenting with granulomatous angiitis of the central nervous system. ( 12528007 )
2003
18
Leptomeningeal enhancement and venous abnormalities in granulomatous angiitis of the central nervous system. ( 12782929 )
2003
19
Granulomatous angiitis of the central nervous system associated with herpes zoster. ( 12126361 )
2002
20
Multiple perforated ulcers of the small intestine associated with allergic granulomatous angiitis: report of a case. ( 12107783 )
2002
21
Allergic granulomatous angiitis (Churg-Strauss syndrome) associated with allergic bronchopulmonary candidiasis. ( 11070467 )
2000
22
Granulomatous angiitis of the CNS causing spontaneous intracerebral haemorrhage: the importance of leptomeningeal biopsy. ( 9854994 )
1998
23
Idiopathic granulomatous angiitis of the CNS manifesting as diffuse white matter disease. ( 9855557 )
1998
24
Idiopathic granulomatous angiitis of the CNS manifesting as diffuse white matter disease. ( 9855556 )
1998
25
Granulomatous angiitis following primary varicella zoster infection. ( 18639020 )
1998
26
Peripheral neuropathy in allergic granulomatous angiitis. ( 9339654 )
1997
27
Idiopathic granulomatous angiitis of the CNS manifesting as diffuse white matter disease. ( 9409370 )
1997
28
Serum interleukin-5 levels in a case with allergic granulomatous angiitis. ( 9372332 )
1997
29
Idiopathic granulomatous angiitis of the central nervous system in pregnancy: the first case report. ( 9029388 )
1997
30
Granulomatous angiitis of the nervous system. ( 9367966 )
1997
31
Indolent granulomatous angiitis. Case report. ( 8057158 )
1994
32
Churg-Strauss syndrome (allergic granulomatous angiitis) with multiple perforating ulcers of the small intestine, multiple ulcers of the colon, and mononeuritis multiplex. ( 8012511 )
1994
33
Clinical recognition of granulomatous angiitis of the brain. Novel magnetic resonance image. ( 8136580 )
1994
34
Neuropathy associated with Churg-Strauss syndrome (allergic granulomatous angiitis). ( 7859666 )
1994
35
Granulomatous angiitis of the spinal cord: a case report. ( 8190233 )
1994
36
Primary (granulomatous) angiitis of the central nervous system with multiple aneurysms of spinal arteries. Case report. ( 8410233 )
1993
37
Granulomatous angiitis of the central nervous system--case report. ( 7689187 )
1993
38
Idiopathic granulomatous angiitis of the central nervous system. Diagnostic challenges. ( 8363446 )
1993
39
Herpes zoster ophthalmicus with orbital pseudotumor syndrome complicated by optic nerve infarction and cerebral granulomatous angiitis: MR-pathologic correlation. ( 8427086 )
1993
40
Non-infectious granulomatous angiitis of central nervous system--an autopsy report. ( 1344229 )
1992
41
Serum interleukin-2 receptor and interferon-alpha levels in a patient with allergic granulomatous angiitis (Churg-Strauss). ( 1450510 )
1992
42
Allergic granulomatous angiitis and peripheral nerve lesion. ( 1335806 )
1992
43
Isolated granulomatous angiitis of the spinal cord. ( 1456744 )
1992
44
Cerebral amyloid angiopathy with granulomatous angiitis ameliorated by steroid-cytoxan treatment. ( 1394245 )
1992
45
Granulomatous angiitis of the central nervous system--a case with recurrent intracerebral hemorrhage. ( 1280342 )
1992
46
Primary (granulomatous) angiitis of the central nervous system: a clinicopathologic analysis of 15 new cases and a review of the literature. ( 1740300 )
1992
47
Systemic necrotizing vasculitis with renal involvement accompanied by remarkable eosinophilia: a case with overlapping features of polyarteritis nodosa and allergic granulomatous angiitis. ( 1687066 )
1991
48
A case of melena caused by a hepatic aneurysm ruptured into the intrahepatic bile duct in a patient with allergic granulomatous angiitis. ( 1960909 )
1991
49
Granulomatous angiitis of the spinal cord associated with Hodgkin's disease. ( 1873784 )
1991
50
Granulomatous angiitis and cerebral amyloid angiopathy presenting as a mass lesion. ( 1713309 )
1991

Variations for Granulomatous Angiitis

Expression for Granulomatous Angiitis

Search GEO for disease gene expression data for Granulomatous Angiitis.

Pathways for Granulomatous Angiitis

GO Terms for Granulomatous Angiitis

Cellular components related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 ABRA ACE CD68 EGF GRM5 HYLS1
2 extracellular space GO:0005615 9.65 A1BG ACE AVP CRP CST3 EGF
3 extracellular region GO:0005576 9.36 A1BG ACE AVP CRP CST3 EGF

Biological processes related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.77 AVP EGF IL5 NOTCH1 PRTN3
2 membrane organization GO:0061024 9.67 AVP EGF MBP
3 neuronal stem cell population maintenance GO:0097150 9.52 JAG1 NOTCH1
4 aortic valve morphogenesis GO:0003180 9.51 JAG1 NOTCH1
5 negative regulation of stem cell differentiation GO:2000737 9.48 JAG1 NOTCH1
6 pulmonary valve morphogenesis GO:0003184 9.46 JAG1 NOTCH1
7 cardiac septum morphogenesis GO:0060411 9.43 JAG1 NOTCH1
8 response to muramyl dipeptide GO:0032495 9.4 JAG1 NOTCH1
9 positive regulation of protein tyrosine kinase activity GO:0061098 9.33 ACE EGF GRM5
10 positive regulation of systemic arterial blood pressure GO:0003084 9.32 ACE AVP
11 Notch signaling involved in heart development GO:0061314 9.26 JAG1 NOTCH1
12 distal tubule development GO:0072017 8.96 JAG1 NOTCH1
13 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 8.62 JAG1 NOTCH1

Molecular functions related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.02 CRP EGF JAG1 NOTCH1 THBD
2 Notch binding GO:0005112 8.96 JAG1 NOTCH1

Sources for Granulomatous Angiitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....