MCID: GRN006
MIFTS: 43

Granulomatous Angiitis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Granulomatous Angiitis

MalaCards integrated aliases for Granulomatous Angiitis:

Name: Granulomatous Angiitis 12 15 74
Vasculitis, Central Nervous System 45

Classifications:



External Ids:

Disease Ontology 12 DOID:2555
MeSH 45 D020293
NCIt 51 C34653
UMLS 74 C0018202

Summaries for Granulomatous Angiitis

MalaCards based summary : Granulomatous Angiitis, also known as vasculitis, central nervous system, is related to churg-strauss syndrome and chronic meningitis. An important gene associated with Granulomatous Angiitis is IL5 (Interleukin 5), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Prednisone and Hormones have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Granulomatous Angiitis

Diseases related to Granulomatous Angiitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 32.4 IL5 PRTN3 THBD
2 chronic meningitis 30.3 CRP IL5
3 vasculitis 29.6 CRP PRTN3 THBD
4 central nervous system vasculitis 12.0
5 primary angiitis of the central nervous system 11.3
6 allergic angiitis 10.5
7 eosinophilic granulomatosis with polyangiitis 10.5
8 herpes zoster 10.3
9 oculomotor nerve paralysis 10.3 AVP MBP
10 third cranial nerve disease 10.3 AVP MBP
11 central pontine myelinolysis 10.3 AVP MBP
12 lymphoma 10.3
13 generalized atherosclerosis 10.2 ACE CRP
14 bronchus cancer 10.2 AVP CRP
15 paralytic ileus 10.2 AVP CRP
16 neuropathy 10.2
17 nodular regenerative hyperplasia 10.2 JAG1 NOTCH1
18 lymphohistiocytoid mesothelioma 10.2 CD68 THBD
19 multicentric castleman disease 10.2 CRP IL5
20 dental abscess 10.2 AVP CRP
21 pyomyositis 10.2 CRP NOTCH1
22 sphenoid sinusitis 10.2 AVP CRP
23 subclavian steal syndrome 10.2 CRP NOTCH1
24 fiedler's myocarditis 10.2 ACE CD68
25 vascular dementia 10.2 ACE CST3 MBP
26 cerebral amyloid angiopathy, cst3-related 10.2
27 lymphoma, hodgkin, classic 10.2
28 herpes zoster ophthalmicus 10.2
29 syndrome of inappropriate antidiuretic hormone 10.1 ACE AVP
30 pericoronitis 10.1 CD68 CRP
31 carotid artery disease 10.1 ACE CRP THBD
32 peripheral vascular disease 10.1 ACE CRP THBD
33 systolic heart failure 10.1 ACE CRP CST3
34 peripheral artery disease 10.1 ACE CRP CST3
35 end stage renal failure 10.1 ACE CRP CST3
36 temporal arteritis 10.1
37 peripheral nervous system disease 10.1
38 meningitis 10.1
39 ossifying fibroma 10.1 JAG1 NOTCH1
40 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.1 EGF JAG1 NOTCH1
41 petroclival meningioma 10.1 CD68 NOTCH1
42 nervous system disease 10.0 ACE CRP MBP
43 aortic coarctation 10.0 ACE NOTCH1
44 non-suppurative otitis media 10.0 IL5 PRTN3
45 aortic valve disease 1 10.0 ACE CRP NOTCH1
46 carotid artery occlusion 10.0 MBP THBD
47 xanthogranulomatous pyelonephritis 9.9 CD68 CRP EGF
48 autosomal dominant polycystic kidney disease 9.9 ACE AVP CST3 EGF
49 pulmonary venoocclusive disease 1, autosomal dominant 9.9
50 hemorrhage, intracerebral 9.9

Graphical network of the top 20 diseases related to Granulomatous Angiitis:



Diseases related to Granulomatous Angiitis

Symptoms & Phenotypes for Granulomatous Angiitis

GenomeRNAi Phenotypes related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

27 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.75 HYLS1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.75 CRP CST3 HYLS1 NOTCH1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.75 HYLS1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.75 NOTCH1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.75 CRP HYLS1 NOTCH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.75 CRP NOTCH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.75 CST3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.75 CST3 HYLS1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.75 NOTCH1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.75 CST3 NOTCH1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.75 CRP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.75 HYLS1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.75 NOTCH1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.75 CRP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.75 NOTCH1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.75 HYLS1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.75 NOTCH1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.75 CST3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.75 HYLS1

MGI Mouse Phenotypes related to Granulomatous Angiitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 ABRA ACE AVP CRP CST3 IL5
2 immune system MP:0005387 9.28 ACE CD68 CRP EGF IL5 MBP

Drugs & Therapeutics for Granulomatous Angiitis

Drugs for Granulomatous Angiitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53-03-2 5865
2 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8
Infliximab Approved Phase 3,Phase 2 170277-31-3
9
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 83-43-2 6741
11
Prednisolone Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 50-24-8 5755
12
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 302-25-0
13
Methotrexate Approved Phase 3,Phase 2 1959-05-2, 59-05-2 126941
14
leucovorin Approved Phase 3,Phase 2 58-05-9 143 6006
15
Hydroxychloroquine Approved Phase 3 118-42-3 3652
16
Adalimumab Approved Phase 3 331731-18-1 16219006
17
Etanercept Approved, Investigational Phase 3 185243-69-0
18
Alendronate Approved Phase 3 66376-36-1, 121268-17-5 2088
19
Abatacept Approved Phase 3,Phase 2 332348-12-6 10237
20
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
21
Leflunomide Approved, Investigational Phase 3 75706-12-6 3899
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-30-3 6037
23
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
24
Alfacalcidol Approved, Nutraceutical Phase 3 41294-56-8 5282181
25
Prednisolone hemisuccinate Experimental Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 2920-86-7
26 Upadacitinib Investigational Phase 3 1310726-60-3
27 Gastrointestinal Agents Phase 3,Phase 2,Not Applicable
28 Dermatologic Agents Phase 3,Phase 2,Phase 1,Not Applicable
29 Antirheumatic Agents Phase 3,Phase 2,Not Applicable
30 Immunologic Factors Phase 3,Phase 2,Not Applicable
31 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
32 Anti-Infective Agents Phase 3,Not Applicable
33 Methylprednisolone Acetate Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
34 Antiemetics Phase 2, Phase 3,Phase 3,Not Applicable
35 Protective Agents Phase 2, Phase 3,Phase 3,Not Applicable
36 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Not Applicable
37 Neuroprotective Agents Phase 2, Phase 3,Phase 3,Not Applicable
38 Autonomic Agents Phase 2, Phase 3,Phase 3,Not Applicable
39 Prednisolone acetate Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
40 Pharmaceutical Solutions Phase 3,Not Applicable
41 Folate Phase 3,Phase 2
42 Antimetabolites, Antineoplastic Phase 3,Phase 2
43 Vitamin B9 Phase 3,Phase 2
44 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
45 Antimetabolites Phase 3,Phase 2
46 Vitamin B Complex Phase 3,Phase 2
47 Folic Acid Antagonists Phase 3,Phase 2
48 Antiparasitic Agents Phase 3
49 Antimalarials Phase 3
50 Antiprotozoal Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 96)
# Name Status NCT ID Phase Drugs
1 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4 Prednisone therapy and pharmacokinetic
2 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4 prednisone
3 Tocilizumab Plus a Short Prednisone Taper for GCA Recruiting NCT03726749 Phase 4 Tocilizumab;Prednisone
4 Tocilizumab Dose-tapering and Interruption in Patients With Giant Cell Arteritis Achieving the Clinical Remission. Recruiting NCT03244709 Phase 4 Tocilizumab
5 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3 infliximab;inactive powder
6 An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) Completed NCT01791153 Phase 3 Tocilizumab;Prednisone;Tocilizumab Placebo;Prednisone Placebo;Corticosteroids;Methotrexate
7 Hydroxychloroquine in Giant Cell Arteritis Completed NCT00430807 Phase 3 hydroxychloroquine/placebo
8 Timed Release Tablet Prednisone in Polymyalgia Rheumatica Completed NCT00836810 Phase 2, Phase 3 Timed Release Tablet Prednisone;Prednisolone
9 HECTHOR: Humira to Spare Steroids in Giant Cell Arteritis Completed NCT00305539 Phase 3 adalimumab;placebo
10 Etanercept Treatment in the Early Course of Polymyalgia Rheumatica Completed NCT00524381 Phase 3 Etanercept (Enbrel);Sodium chloride (placebo)
11 Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol. Completed NCT00138983 Phase 3 Alendronate versus alfacalcidol (1-alpha OH vitamin D)
12 A Study to Evaluate the Safety and Efficacy of Upadacitinib in Participants With Giant Cell Arteritis Recruiting NCT03725202 Phase 3 Upadacitinib;Corticosteroid (CS)
13 Evaluation of Efficacy and Safety of Sarilumab in Patients With GCA Recruiting NCT03600805 Phase 3 Sarilumab SAR153191;Sarilumab matching placebo;Prednisone;Prednisone matching placebo
14 Abatacept in earLy Onset Polymyalgia Rheumatica: Study ALORS Recruiting NCT03632187 Phase 3 Abatacept;Placebos
15 Evaluation of the Efficacy and Safety of Sarilumab in Patients With Polymyalgia Rheumatica Recruiting NCT03600818 Phase 3 Sarilumab SAR153191 (REGN88);Sarilumab-matching placebo;Prednisone;Prednisone-matching placebo;Prednisone
16 A Study to Evaluate the Efficacy of Tocilizumab as a Remission-Induction and Glucocorticoid-Sparing Regimen in Subjects With New-Onset Polymyalgia Rheumatica (PMR- SPARE) Recruiting NCT03263715 Phase 3 Tocilizumab Prefilled Syringe [Actemra];Placebos;Glucocorticoids
17 Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORE Recruiting NCT02908217 Phase 3 Tocilizumab;Placebo
18 An Extension Study to Evaluate Long-Term Safety of Subcutaneous (SC) Tocilizumab in Participants With Giant Cell Arteritis (GCA) Active, not recruiting NCT03202368 Phase 3 Tocilizumab
19 MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter, Randomized, Controlled Trial Not yet recruiting NCT03892785 Phase 3 Prednisone treatment;Tocilizumab treatment;Methotrexate treatment
20 Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBO Not yet recruiting NCT03841734 Phase 3 treatment
21 Giant Cell Arteritis and Anakinra Trial Not yet recruiting NCT02902731 Phase 3 PLACEBO;ANAKINRA
22 Treatment With Leflunomide in Patients With Polymyalgia Rheumatica Not yet recruiting NCT03576794 Phase 3 Leflunomide 20 mg;Prednisolone
23 Efficacy and Safety Study of Sirukumab in Patients With Giant Cell Arteritis Terminated NCT02531633 Phase 2, Phase 3 Sirukumab;Placebo to match sirukumab;Prednisone;Placebo to match prednisone
24 A Study Assessing the Efficacy and Safety of Lodotra® Compared to Prednisone IR in Subjects Suffering From PMR Terminated NCT01821040 Phase 3 Lodotra®;Prednisone IR (immediate release)
25 A Study to Evaluate Efficacy and Safety of Subcutaneous Abatacept With Steroid Treatment Compared to Steroid Treatment Alone in Adults With Giant Cell Arteritis (GCA) Withdrawn NCT03192969 Phase 3 Abatacept;Glucocorticoid Treatment
26 Efficacy and Safety Study of Sirukumab in Subjects With Polymyalgia Rheumatica Withdrawn NCT02899026 Phase 3 Sirukumab;Placebo to match sirukumab;Prednisone /Prednisone placebo
27 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
28 Evaluation of Tocilizumab as an add-on Therapy to Corticoids in Giant Cell Arteritis: Proof of Concept Study. Completed NCT01910038 Phase 2 corticoids+ tocilizumab 8mg/Kg/4 weeks
29 Tocilizumab for Patients With Giant Cell Arteritis Completed NCT01450137 Phase 2 Tocilizumab + Glucocorticoids (GCs);Placebo + Glucocorticoids (GCs)
30 Tocilizumab Effect iN pOlymyalgia Rheumatica Completed NCT01713842 Phase 2 TCZ
31 Study of Tocilizumab to Treat Polymyalgia Rheumatica Completed NCT01396317 Phase 2 Tocilizumab
32 Abatacept for Treating Adults With Giant Cell Arteritis and Takayasu's Arteritis Completed NCT00556439 Phase 2 Abatacept;Placebo
33 Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis Completed NCT00004686 Phase 2 methotrexate;prednisone
34 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
35 KPL-301 for Subjects With Giant Cell Arteritis Recruiting NCT03827018 Phase 2
36 A Placebo-controlled Phase 2 Trial to Investigate the Safety and Efficacy of Secukinumab in Giant Cell Arteritis Recruiting NCT03765788 Phase 2 Prednisolone;Placebo to match Secukinumab, s.c.
37 Giant Cell Arteritis Treatment With Ultra-short Glucocorticoids and Tocilizumab Recruiting NCT03745586 Phase 1, Phase 2 Tocilizumab;Glucocorticoids
38 Ustekinumab for the Treatment of Relapse of Refractory Giant Cell Arteritis Recruiting NCT03711448 Phase 2 prednisone treatment;prednisone and ustekinumab treatment
39 Baricitinib in Relapsing Giant Cell Arteritis Recruiting NCT03026504 Phase 2 Baricitinib
40 Ustekinumab for the Treatment of Giant Cell Arteritis Recruiting NCT02955147 Phase 1, Phase 2 Ustekinumab;Prednisone
41 Use of Gallium-68 HA-DOTATATE PET/CT in Giant Cell Arteritis (GCA) Not yet recruiting NCT03812302 Phase 2
42 Delayed Release Prednisone in PMR Terminated NCT02702778 Phase 2 Delayed-Release (DR) Prednisone;Immediate Release (IR) Prednisone
43 A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica Terminated NCT01364389 Phase 2 AIN457;ACZ885;Prednisone;Placebo
44 A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Giant Cell Arteritis Terminated NCT00076726 Phase 2 Infliximab
45 MRI Superficial Temporal Artery Completed NCT00188448 Phase 1
46 A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Participants With Giant Cell Arteritis (GCA). Not yet recruiting NCT03923738 Phase 1 Tocilizumab
47 Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer and Pre-existing Autoimmune Disease Not yet recruiting NCT03656627 Phase 1 Nivolumab
48 Study of Phenotypic and Functional Characteristics of Regulatory T Lymphocytes in Horton's Disease Unknown status NCT02857192 Not Applicable
49 Study of the T CD8 Immune Response in Horton's Disease Unknown status NCT02158208
50 Giant Cell Arteritis: Improving Use of Ultrasound Evaluation Unknown status NCT02523625

Search NIH Clinical Center for Granulomatous Angiitis

Cochrane evidence based reviews: vasculitis, central nervous system

Genetic Tests for Granulomatous Angiitis

Anatomical Context for Granulomatous Angiitis

MalaCards organs/tissues related to Granulomatous Angiitis:

42
Lung, Brain, Kidney, Bone, Heart, Spinal Cord, Small Intestine

Publications for Granulomatous Angiitis

Articles related to Granulomatous Angiitis:

(show top 50) (show all 117)
# Title Authors Year
1
Granulomatous Angiitis: Twenty Years Later. ( 30952409 )
2019
2
Granulomatous Angiitis of the Central Nervous System Associated with Hodgkin's Lymphoma: Case Report and Literature Review. ( 28943218 )
2018
3
Primary granulomatous angiitis of the central nervous system with amyloid angiopathy: a case report and literature review. ( 25692513 )
2015
4
Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma. ( 23269593 )
2013
5
Primary granulomatous angiitis of the CNS preferentially involving small veins with a granulomatous leukoencephalitis-like lesion in the cerebrum. ( 23279573 )
2013
6
Effective intravenous immunoglobulin therapy for Churg-Strauss syndrome (allergic granulomatous angiitis) complicated by neuropathy of the eighth cranial nerve: a case report. ( 22989316 )
2012
7
A remarkable pattern of subcortical vessel wall enhancement in granulomatous angiitis of the central nervous system. ( 23028033 )
2012
8
Teaching NeuroImages: granulomatous angiitis of the CNS associated with Hodgkin lymphoma. ( 22067969 )
2011
9
Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist. ( 20607580 )
2010
10
Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. ( 19253257 )
2009
11
Granulomatous angiitis leading to a pulmonary veno-occlusive disease-like picture. ( 19251802 )
2009
12
Primary granulomatous angiitis of the central nervous system: findings of magnetic resonance spectroscopy and fractional anisotropy in diffusion tensor imaging prior to surgery. Case report. ( 17937238 )
2007
13
Relapsing granulomatous angiitis of the central nervous system in a patient while in remission from Hodgkin lymphoma. ( 17144241 )
2006
14
Concurrent occurrence of allergic granulomatous angiitis and temporal arteritis: a case report and review of the literature. ( 17029049 )
2005
15
Churg-Strauss syndrome (allergic granulomatous angiitis) associated with T lymphoblastic lymphoma. ( 15369188 )
2004
16
Granulomatous angiitis of the central nervous system revealing Hodgkin's disease. ( 15164198 )
2004
17
The Churg Strauss syndrome (allergic granulomatous angiitis): review and update. ( 14625818 )
2003
18
Hodgkins disease presenting with granulomatous angiitis of the central nervous system. ( 12528007 )
2003
19
Leptomeningeal enhancement and venous abnormalities in granulomatous angiitis of the central nervous system. ( 12782929 )
2003
20
Multiple perforated ulcers of the small intestine associated with allergic granulomatous angiitis: report of a case. ( 12107783 )
2002
21
Granulomatous angiitis of the central nervous system associated with herpes zoster. ( 12126361 )
2002
22
Allergic granulomatous angiitis (Churg-Strauss syndrome) associated with allergic bronchopulmonary candidiasis. ( 11070467 )
2000
23
Granulomatous angiitis of the CNS causing spontaneous intracerebral haemorrhage: the importance of leptomeningeal biopsy. ( 9854994 )
1998
24
Idiopathic granulomatous angiitis of the CNS manifesting as diffuse white matter disease. ( 9855556 )
1998
25
Idiopathic granulomatous angiitis of the CNS manifesting as diffuse white matter disease. ( 9855557 )
1998
26
Granulomatous angiitis following primary varicella zoster infection. ( 18639020 )
1998
27
Idiopathic granulomatous angiitis of the central nervous system in pregnancy: the first case report. ( 9029388 )
1997
28
Peripheral neuropathy in allergic granulomatous angiitis. ( 9339654 )
1997
29
Granulomatous angiitis of the nervous system. ( 9367966 )
1997
30
Serum interleukin-5 levels in a case with allergic granulomatous angiitis. ( 9372332 )
1997
31
Idiopathic granulomatous angiitis of the CNS manifesting as diffuse white matter disease. ( 9409370 )
1997
32
Neuropathy associated with Churg-Strauss syndrome (allergic granulomatous angiitis). ( 7859666 )
1994
33
Churg-Strauss syndrome (allergic granulomatous angiitis) with multiple perforating ulcers of the small intestine, multiple ulcers of the colon, and mononeuritis multiplex. ( 8012511 )
1994
34
Indolent granulomatous angiitis. Case report. ( 8057158 )
1994
35
Clinical recognition of granulomatous angiitis of the brain. Novel magnetic resonance image. ( 8136580 )
1994
36
Granulomatous angiitis of the spinal cord: a case report. ( 8190233 )
1994
37
Granulomatous angiitis of the central nervous system--case report. ( 7689187 )
1993
38
Idiopathic granulomatous angiitis of the central nervous system. Diagnostic challenges. ( 8363446 )
1993
39
Primary (granulomatous) angiitis of the central nervous system with multiple aneurysms of spinal arteries. Case report. ( 8410233 )
1993
40
Herpes zoster ophthalmicus with orbital pseudotumor syndrome complicated by optic nerve infarction and cerebral granulomatous angiitis: MR-pathologic correlation. ( 8427086 )
1993
41
Granulomatous angiitis of the central nervous system--a case with recurrent intracerebral hemorrhage. ( 1280342 )
1992
42
Allergic granulomatous angiitis and peripheral nerve lesion. ( 1335806 )
1992
43
Non-infectious granulomatous angiitis of central nervous system--an autopsy report. ( 1344229 )
1992
44
Cerebral amyloid angiopathy with granulomatous angiitis ameliorated by steroid-cytoxan treatment. ( 1394245 )
1992
45
Serum interleukin-2 receptor and interferon-alpha levels in a patient with allergic granulomatous angiitis (Churg-Strauss). ( 1450510 )
1992
46
Isolated granulomatous angiitis of the spinal cord. ( 1456744 )
1992
47
Primary (granulomatous) angiitis of the central nervous system: a clinicopathologic analysis of 15 new cases and a review of the literature. ( 1740300 )
1992
48
Systemic necrotizing vasculitis with renal involvement accompanied by remarkable eosinophilia: a case with overlapping features of polyarteritis nodosa and allergic granulomatous angiitis. ( 1687066 )
1991
49
Granulomatous angiitis and cerebral amyloid angiopathy presenting as a mass lesion. ( 1713309 )
1991
50
Pulmonary vascular involvement in sarcoidosis: granulomatous angiitis and microangiopathy in transbronchial lung biopsies. ( 1850897 )
1991

Variations for Granulomatous Angiitis

Expression for Granulomatous Angiitis

Search GEO for disease gene expression data for Granulomatous Angiitis.

Pathways for Granulomatous Angiitis

GO Terms for Granulomatous Angiitis

Cellular components related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.9 ABRA ACE CD68 EGF GRM5 HYLS1
2 extracellular space GO:0005615 9.61 A1BG ACE AVP CRP CST3 EGF
3 extracellular region GO:0005576 9.32 A1BG ACE AVP CRP CST3 EGF

Biological processes related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.84 AVP CRP EGF NOTCH1
2 positive regulation of cell proliferation GO:0008284 9.72 AVP EGF IL5 NOTCH1 PRTN3
3 membrane organization GO:0061024 9.67 AVP EGF MBP
4 ERK1 and ERK2 cascade GO:0070371 9.57 AVP EGF
5 branching morphogenesis of an epithelial tube GO:0048754 9.56 EGF NOTCH1
6 positive regulation of JAK-STAT cascade GO:0046427 9.55 IL5 NOTCH1
7 neuronal stem cell population maintenance GO:0097150 9.52 JAG1 NOTCH1
8 aortic valve morphogenesis GO:0003180 9.51 JAG1 NOTCH1
9 negative regulation of stem cell differentiation GO:2000737 9.48 JAG1 NOTCH1
10 pulmonary valve morphogenesis GO:0003184 9.46 JAG1 NOTCH1
11 cardiac septum morphogenesis GO:0060411 9.43 JAG1 NOTCH1
12 response to muramyl dipeptide GO:0032495 9.4 JAG1 NOTCH1
13 positive regulation of systemic arterial blood pressure GO:0003084 9.37 ACE AVP
14 positive regulation of protein tyrosine kinase activity GO:0061098 9.33 ACE EGF GRM5
15 Notch signaling involved in heart development GO:0061314 9.26 JAG1 NOTCH1
16 distal tubule development GO:0072017 8.96 JAG1 NOTCH1
17 positive regulation of cardiac epithelial to mesenchymal transition GO:0062043 8.62 JAG1 NOTCH1

Molecular functions related to Granulomatous Angiitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.02 CRP EGF JAG1 NOTCH1 THBD
2 Notch binding GO:0005112 8.96 JAG1 NOTCH1

Sources for Granulomatous Angiitis

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
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52 NDF-RT
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56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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