MCID: GRN003
MIFTS: 37

Granulomatous Dermatitis

Categories: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

MalaCards integrated aliases for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4397
NCIt 50 C3505
UMLS 73 C0743086

Summaries for Granulomatous Dermatitis

MalaCards based summary : Granulomatous Dermatitis is related to arthritis and blau syndrome. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. Affiliated tissues include neutrophil, skin and prostate, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Granulomatous Dermatitis

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.7 NOD2 TNF TNFRSF1B
2 blau syndrome 30.1 NOD2 TNF
3 uveitis 29.9 NOD2 TNF
4 lymphadenitis 29.8 NOD2 TNF
5 silicosis 29.7 ACE TNF
6 spondyloarthropathy 1 29.6 NOD2 TNF TNFRSF1B
7 spondylitis 29.6 NOD2 TNF TNFRSF1B
8 interstitial granulomatous dermatitis with arthritis 12.5
9 dermatitis 10.9
10 rheumatoid arthritis 10.3
11 lupus erythematosus 10.3
12 systemic lupus erythematosus 10.3
13 ileocolitis 10.1 NOD2 TNF
14 crohn's colitis 10.1 NOD2 TNF
15 streptococcal meningitis 10.1 NOD2 TNF
16 spondylarthropathy 10.1 NOD2 TNF
17 inflammatory bowel disease 3 10.1 NOD2 TNF
18 orofacial granulomatosis 10.1 NOD2 TNF
19 hidradenitis suppurativa 10.1 NOD2 TNF
20 hidradenitis 10.1 NOD2 TNF
21 pyoderma 10.1 NOD2 TNF
22 pyoderma gangrenosum 10.1 NOD2 TNF
23 ileitis 10.1 NOD2 TNF
24 q fever 10.1 NOD2 TNF
25 acute graft versus host disease 10.1 NOD2 TNF
26 juvenile ankylosing spondylitis 10.1 TNF TNFRSF1B
27 chronic gonococcal salpingitis 10.1 TNF TNFRSF1B
28 scleral disease 10.1 TNF TNFRSF1B
29 pustulosis of palm and sole 10.1 TNF TNFRSF1B
30 rheumatoid lung disease 10.1 TNF TNFRSF1B
31 peroneal neuropathy 10.1 TNF TNFRSF1B
32 periodic fever, familial, autosomal dominant 10.1 TNF TNFRSF1B
33 acute salpingitis 10.1 TNF TNFRSF1B
34 leprosy 3 10.1 NOD2 TNF
35 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1B
36 chronic salpingitis 10.1 TNF TNFRSF1B
37 panuveitis 10.1 TNF TNFRSF1B
38 familial mediterranean fever 10.1 NOD2 TNF
39 myelodysplastic syndrome 10.1
40 ulcerative colitis 10.1
41 lymphoma 10.1
42 colitis 10.1
43 wells syndrome 10.1
44 cogan syndrome 10.1 TNF TNFRSF1B
45 palindromic rheumatism 10.1 TNF TNFRSF1B
46 exanthem 10.1 TNF TNFRSF1B
47 uveoparotid fever 10.1 ACE TNF
48 subacute cutaneous lupus erythematosus 10.1 ACE TNF
49 guillain-barre syndrome 10.1 TNF TNFRSF1B
50 posterior urethral valves 10.1 ACE TNF

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to Granulomatous Dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

GenomeRNAi Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.55 ACE NOD2 TNF TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.55 ACE NOD2 TNF TNFRSF1B BRAF

MGI Mouse Phenotypes related to Granulomatous Dermatitis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.95 ACE BRAF FOXC1 NOD2 TNF TNFRSF1B
2 cardiovascular system MP:0005385 9.93 ACE BRAF FOXC1 TNF TNFRSF1B
3 digestive/alimentary MP:0005381 9.91 BRAF FOXC1 NOD2 TNF TNFRSF1B
4 homeostasis/metabolism MP:0005376 9.91 ACE BRAF FOXC1 NOD2 TNF TNFRSF1B
5 endocrine/exocrine gland MP:0005379 9.89 ACE BRAF FOXC1 TNF TNFRSF1B
6 adipose tissue MP:0005375 9.85 ACE BRAF TNF TNFRSF1B
7 hematopoietic system MP:0005397 9.85 ACE BRAF NOD2 TNF TNFRSF1B
8 mortality/aging MP:0010768 9.85 ACE BRAF FOXC1 NOD2 TNF TNFRSF1B
9 craniofacial MP:0005382 9.83 BRAF FOXC1 TNF TNFRSF1B
10 liver/biliary system MP:0005370 9.8 ACE BRAF FOXC1 TNF TNFRSF1B
11 muscle MP:0005369 9.62 BRAF FOXC1 TNF TNFRSF1B
12 neoplasm MP:0002006 9.56 ACE BRAF TNF TNFRSF1B
13 renal/urinary system MP:0005367 9.46 ACE BRAF FOXC1 TNFRSF1B
14 respiratory system MP:0005388 9.26 BRAF FOXC1 TNF TNFRSF1B
15 skeleton MP:0005390 9.02 BRAF FOXC1 NOD2 TNF TNFRSF1B

Drugs & Therapeutics for Granulomatous Dermatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

MalaCards organs/tissues related to Granulomatous Dermatitis:

41
Neutrophil, Skin, Prostate, Thyroid, B Cells, Bone, Heart

Publications for Granulomatous Dermatitis

Articles related to Granulomatous Dermatitis:

(show top 50) (show all 205)
# Title Authors Year
1
Interstitial granulomatous dermatitis in a patient with chronic hepatitis C and mixed cryoglobulinemia. ( 29469770 )
2018
2
Interstitial Granulomatous Dermatitis due to a Rare Myeloproliferative Neoplasia. ( 29937566 )
2018
3
Interstitial granulomatous dermatitis and palisaded neutrophilic granulomatous dermatitis. ( 29894543 )
2018
4
Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. ( 29226345 )
2018
5
Granulomatous dermatitis associated with ipilimumab therapy (ipilimumab associated granulomatous dermatitis). ( 29704281 )
2018
6
The histological spectrum of talimogene laherparepvec (TVEC) injections-Neutrophilic and chronic granulomatous dermatitis. ( 30414194 )
2018
7
Image Gallery: Granulomatous dermatitis due to infection with the chlorophyllic green alga Desmodesmus. ( 30318802 )
2018
8
Palisaded neutrophilic and granulomatous dermatitis associated with systemic lupus erythematosus: possible involvement of CD163+ M2 macrophages in two cases, and a review of published works. ( 30376790 )
2018
9
Subclinical granulomas in benign skin lesions heralding the onset of BRAF and MEK inhibitor-associated granulomatous dermatitis in a patient with metastatic melanoma. ( 30167445 )
2018
10
Recurrent Palisaded Neutrophilic and Granulomatous Dermatitis in the Setting of Systemic Lupus Erythematosus. ( 30207535 )
2018
11
Granulomatous dermatitis secondary to vemurafenib in a child with Langerhans cell histiocytosis. ( 30216522 )
2018
12
Granulomatous dermatitis as a postherpetic isotopic response in immunocompromised patients: A report of 5 cases. ( 30246119 )
2018
13
Palisaded neutrophilic and granulomatous dermatitis associated with ledipasvir/sofosbuvir. ( 30246134 )
2018
14
Paraneoplastic granulomatous dermatitis in a patient with Hodgkin's disease: a diagnostic pitfall. ( 30100570 )
2018
15
Chronic Granulomatous Dermatitis Induced by Talimogene Laherparepvec Therapy of Melanoma Metastases. ( 28940544 )
2017
16
Interstitial granulomatous dermatitis associated with primary biliary cirrhosis. ( 28225148 )
2017
17
Palisaded granulomatous dermatitis secondary to recombinant insulin. ( 28252209 )
2017
18
Interstitial Granulomatous Dermatitis (IGD). ( 28785357 )
2017
19
Palisaded neutrophilic and granulomatous dermatitis as a novel cause of hypercalcemia: A case report. ( 28538395 )
2017
20
Palisaded neutrophilic granulomatous dermatitis: Spectrum of histologic findings in a single patient. ( 28932786 )
2017
21
Interstitial granulomatous dermatitis associated with rheumatoid arthritis. ( 28150331 )
2017
22
Use of Molecular Biology Techniques in Sarcoidal Granulomatous Dermatitis: A Clinicopathological and Molecular Approach with Diagnostic Implications. ( 28681062 )
2017
23
Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer. ( 28566913 )
2017
24
Reactive granulomatous dermatitis presenting as subcutaneous nodules and cords in a patient with advanced myelodysplastic syndrome. ( 28220192 )
2017
25
Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism. ( 29469709 )
2017
26
Interstitial granulomatous dermatitis during talimogen laherparepvec treatment. ( 28570389 )
2017
27
Interstitial granulomatous dermatitis with arthritis. ( 29186271 )
2017
28
Interstitial granulomatous dermatitis associated with lupus: A case report. ( 28359766 )
2017
29
Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction. ( 28946733 )
2017
30
Scabies Associated with Granulomatous Dermatitis. ( 28868002 )
2017
31
Postherpetic Granulomatous Dermatitis in a Man Treated With Nivolumab. ( 28532783 )
2017
32
Generalized palisaded neutrophilic and granulomatous dermatitis-a cutaneous manifestation of chronic myelomonocytic leukemia? A clinical, histopathological, and molecular study of 3 cases. ( 28442268 )
2017
33
Palisaded Granulomatous Dermatitis Associated with Ulcerative Colitis: A Comprehensive Literature Review. ( 28168136 )
2017
34
Palisaded Neutrophilic and Granulomatous Dermatitis/Interstitial Granulomatous Dermatitis Overlap: A Striking Clinical and Histologic Presentation With "Burning Rope Sign" and Subsequent Mirror-Image Contralateral Recurrence. ( 28475518 )
2017
35
Palisaded Neutrophilic Granulomatous Dermatitis in a Patient with Systemic Sclerosis-Rheumatoid Arthritis Overlap Syndrome. ( 29200777 )
2017
36
Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept. ( 26860064 )
2016
37
Complete remission of disseminated granulomatous dermatitis related to chronic eosinophilic leukemia following allogeneic stem cell transplantation. ( 27267816 )
2016
38
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. ( 27891733 )
2016
39
Interstitial Granulomatous Dermatitis Associated with Rheumatoid Arthritis. ( 27274645 )
2016
40
Papulonodular mucinosis with interstitial granulomatous dermatitis-like histological changes in a male patient with systemic lupus erythematosus. ( 27421677 )
2016
41
The rope sign: a case of interstitial granulomatous dermatitis with arthritis. ( 26924028 )
2016
42
Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report. ( 27294654 )
2016
43
Interstitial granulomatous dermatitis demonstrating small, discrete skin-colored papules. ( 27373135 )
2016
44
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
45
Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study. ( 28050374 )
2016
46
First reported association of chronic lymphocytic leukaemia and interstitial granulomatous dermatitis. ( 27194675 )
2016
47
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab. ( 27456988 )
2016
48
Interstitial granulomatous dermatitis associated with systemic lupus erythematosus: case report and review of the literature. ( 26385222 )
2015
49
Granulocyte colony-stimulating factor-induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome. ( 25572429 )
2015
50
BRAF Inhibitor-Induced Antitumoral Granulomatous Dermatitis Eruption in Advanced Melanoma. ( 26381028 )
2015

Variations for Granulomatous Dermatitis

Expression for Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for Granulomatous Dermatitis

Pathways related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 BRAF NOD2 TNF TNFRSF1B
2
Show member pathways
12.36 BRAF TNF TNFRSF1B
3
Show member pathways
12.25 BRAF TNF TNFRSF1B
4
Show member pathways
11.9 BRAF TNF TNFRSF1B
5
Show member pathways
11.39 TNF TNFRSF1B
6 11.33 TNF TNFRSF1B
7
Show member pathways
11.22 BRAF TNF
8 11.14 TNF TNFRSF1B
9
Show member pathways
11.07 TNF TNFRSF1B
10 11.01 TNF TNFRSF1B
11 10.84 NOD2 TNF TNFRSF1B
12 10.66 TNF TNFRSF1B
13 10.32 NOD2 TNF

GO Terms for Granulomatous Dermatitis

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 BRAF FOXC1 TNF
2 positive regulation of JNK cascade GO:0046330 9.58 NOD2 TNF
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.57 BRAF TNF
4 cellular response to organic cyclic compound GO:0071407 9.56 NOD2 TNF
5 regulation of inflammatory response GO:0050727 9.55 NOD2 TNF
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.54 TNF TNFRSF1B
7 positive regulation of MAP kinase activity GO:0043406 9.52 NOD2 TNF
8 positive regulation of interleukin-6 production GO:0032755 9.49 NOD2 TNF
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.48 NOD2 TNF
10 JNK cascade GO:0007254 9.46 NOD2 TNF
11 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.43 TNF TNFRSF1B
12 extrinsic apoptotic signaling pathway GO:0097191 9.4 TNF TNFRSF1B
13 negative regulation of mitotic cell cycle GO:0045930 9.37 FOXC1 TNF
14 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.33 BRAF NOD2 TNF
15 blood vessel remodeling GO:0001974 9.32 ACE FOXC1
16 positive regulation of interleukin-8 production GO:0032757 9.26 NOD2 TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.96 TNF TNFRSF1B
18 cellular response to lipopolysaccharide GO:0071222 8.8 NOD2 TNF TNFRSF1B

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 8.62 ACE BRAF

Sources for Granulomatous Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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