MCID: GRN003
MIFTS: 34

Granulomatous Dermatitis

Categories: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

MalaCards integrated aliases for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4397
NCIt 50 C3505
UMLS 73 C0743086

Summaries for Granulomatous Dermatitis

MalaCards based summary : Granulomatous Dermatitis is related to blau syndrome and spondyloarthropathy 1. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Hepatitis C. Affiliated tissues include neutrophil, skin and b cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Granulomatous Dermatitis

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 blau syndrome 30.2 NOD2 TNF
2 spondyloarthropathy 1 29.8 NOD2 TNF
3 ulcerative colitis 29.8 NOD2 TNF
4 lymphadenitis 29.8 NOD2 TNF
5 spondylitis 29.7 NOD2 TNF
6 uveitis 29.5 NOD2 TNF
7 silicosis 29.2 ACE TNF
8 interstitial granulomatous dermatitis with arthritis 12.4
9 dermatitis 10.8
10 arthritis 10.4
11 ileocolitis 10.3 NOD2 TNF
12 crohn's colitis 10.3 NOD2 TNF
13 inflammatory bowel disease 3 10.3 NOD2 TNF
14 orofacial granulomatosis 10.3 NOD2 TNF
15 streptococcal meningitis 10.3 NOD2 TNF
16 hidradenitis suppurativa 10.3 NOD2 TNF
17 hidradenitis 10.3 NOD2 TNF
18 pyoderma gangrenosum 10.3 NOD2 TNF
19 pyoderma 10.3 NOD2 TNF
20 q fever 10.3 NOD2 TNF
21 ileitis 10.3 NOD2 TNF
22 acute graft versus host disease 10.3 NOD2 TNF
23 leprosy 3 10.2 NOD2 TNF
24 congenital hydrocephalus 10.2 FOXC1 TNF
25 familial mediterranean fever 10.2 NOD2 TNF
26 intestinal disease 10.2 NOD2 TNF
27 rheumatoid arthritis 10.2
28 lupus erythematosus 10.1
29 systemic lupus erythematosus 10.1
30 gastrointestinal system disease 10.0 NOD2 TNF
31 myelodysplastic syndrome 10.0
32 lymphoma 10.0
33 colitis 10.0
34 subacute cutaneous lupus erythematosus 9.9 ACE TNF
35 burns 9.9
36 cutaneous leishmaniasis 9.9
37 hepatitis 9.9
38 leishmaniasis 9.9
39 wells syndrome 9.9
40 skin sarcoidosis 9.9 ACE TNF
41 posterior urethral valves 9.9 ACE TNF
42 ischemic heart disease 9.9 ACE TNF
43 systolic heart failure 9.9 ACE TNF
44 extrinsic cardiomyopathy 9.8 ACE TNF
45 rheumatic heart disease 9.8 ACE TNF
46 pyelonephritis 9.8 ACE TNF
47 limb ischemia 9.8 ACE TNF
48 adult respiratory distress syndrome 9.8 ACE TNF
49 scleroderma, familial progressive 9.8
50 ackerman syndrome 9.8

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to Granulomatous Dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

GenomeRNAi Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 ACE NOD2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 ACE BRAF NOD2 TNF

MGI Mouse Phenotypes related to Granulomatous Dermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 ACE BRAF FOXC1 NOD2 TNF
2 digestive/alimentary MP:0005381 9.62 BRAF FOXC1 NOD2 TNF
3 homeostasis/metabolism MP:0005376 9.55 ACE BRAF FOXC1 NOD2 TNF
4 liver/biliary system MP:0005370 9.26 ACE BRAF FOXC1 TNF
5 reproductive system MP:0005389 8.92 ACE BRAF FOXC1 TNF

Drugs & Therapeutics for Granulomatous Dermatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

MalaCards organs/tissues related to Granulomatous Dermatitis:

41
Neutrophil, Skin, B Cells, Prostate, Thyroid, T Cells

Publications for Granulomatous Dermatitis

Articles related to Granulomatous Dermatitis:

(show top 50) (show all 194)
# Title Authors Year
1
Interstitial granulomatous dermatitis in a patient with chronic hepatitis C and mixed cryoglobulinemia. ( 29469770 )
2018
2
Interstitial Granulomatous Dermatitis due to a Rare Myeloproliferative Neoplasia. ( 29937566 )
2018
3
Interstitial granulomatous dermatitis and palisaded neutrophilic granulomatous dermatitis. ( 29894543 )
2018
4
Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. ( 29226345 )
2018
5
Granulomatous dermatitis associated with ipilimumab therapy (ipilimumab associated granulomatous dermatitis). ( 29704281 )
2018
6
Chronic Granulomatous Dermatitis Induced by Talimogene Laherparepvec Therapy of Melanoma Metastases. ( 28940544 )
2017
7
Interstitial granulomatous dermatitis associated with primary biliary cirrhosis. ( 28225148 )
2017
8
Palisaded granulomatous dermatitis secondary to recombinant insulin. ( 28252209 )
2017
9
Interstitial Granulomatous Dermatitis (IGD). ( 28785357 )
2017
10
Palisaded neutrophilic and granulomatous dermatitis as a novel cause of hypercalcemia: A case report. ( 28538395 )
2017
11
Palisaded neutrophilic granulomatous dermatitis: Spectrum of histologic findings in a single patient. ( 28932786 )
2017
12
Interstitial granulomatous dermatitis associated with rheumatoid arthritis. ( 28150331 )
2017
13
Use of Molecular Biology Techniques in Sarcoidal Granulomatous Dermatitis: A Clinicopathological and Molecular Approach with Diagnostic Implications. ( 28681062 )
2017
14
Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer. ( 28566913 )
2017
15
Reactive granulomatous dermatitis presenting as subcutaneous nodules and cords in a patient with advanced myelodysplastic syndrome. ( 28220192 )
2017
16
Ustekinumab to target granulomatous dermatitis in recalcitrant ulcerative necrobiosis lipoidica: case report and proposed mechanism. ( 29469709 )
2017
17
Interstitial granulomatous dermatitis during talimogen laherparepvec treatment. ( 28570389 )
2017
18
Interstitial granulomatous dermatitis with arthritis. ( 29186271 )
2017
19
Interstitial granulomatous dermatitis associated with lupus: A case report. ( 28359766 )
2017
20
Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction. ( 28946733 )
2017
21
Scabies Associated with Granulomatous Dermatitis. ( 28868002 )
2017
22
Postherpetic Granulomatous Dermatitis in a Man Treated With Nivolumab. ( 28532783 )
2017
23
Generalized palisaded neutrophilic and granulomatous dermatitis-a cutaneous manifestation of chronic myelomonocytic leukemia? A clinical, histopathological, and molecular study of 3 cases. ( 28442268 )
2017
24
Palisaded Neutrophilic and Granulomatous Dermatitis/Interstitial Granulomatous Dermatitis Overlap: A Striking Clinical and Histologic Presentation With "Burning Rope Sign" and Subsequent Mirror-Image Contralateral Recurrence. ( 28475518 )
2017
25
Palisaded Neutrophilic Granulomatous Dermatitis in a Patient with Systemic Sclerosis-Rheumatoid Arthritis Overlap Syndrome. ( 29200777 )
2017
26
Palisaded Granulomatous Dermatitis Associated with Ulcerative Colitis: A Comprehensive Literature Review. ( 28168136 )
2017
27
Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept. ( 26860064 )
2016
28
Complete remission of disseminated granulomatous dermatitis related to chronic eosinophilic leukemia following allogeneic stem cell transplantation. ( 27267816 )
2016
29
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. ( 27891733 )
2016
30
Interstitial Granulomatous Dermatitis Associated with Rheumatoid Arthritis. ( 27274645 )
2016
31
Papulonodular mucinosis with interstitial granulomatous dermatitis-like histological changes in a male patient with systemic lupus erythematosus. ( 27421677 )
2016
32
The rope sign: a case of interstitial granulomatous dermatitis with arthritis. ( 26924028 )
2016
33
Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report. ( 27294654 )
2016
34
Interstitial granulomatous dermatitis demonstrating small, discrete skin-colored papules. ( 27373135 )
2016
35
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
36
Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study. ( 28050374 )
2016
37
First reported association of chronic lymphocytic leukaemia and interstitial granulomatous dermatitis. ( 27194675 )
2016
38
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab. ( 27456988 )
2016
39
Interstitial granulomatous dermatitis associated with systemic lupus erythematosus: case report and review of the literature. ( 26385222 )
2015
40
Granulocyte colony-stimulating factor-induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome. ( 25572429 )
2015
41
BRAF Inhibitor-Induced Antitumoral Granulomatous Dermatitis Eruption in Advanced Melanoma. ( 26381028 )
2015
42
Interstitial Granulomatous Dermatitis: A Clinicopathological Study. ( 25830722 )
2015
43
Herpes zoster granulomatous dermatitis: histopathologic findings in a case series. ( 25970643 )
2015
44
Chronic Interstitial Granulomatous Dermatitis in Coccidioidomycosis. ( 26574343 )
2015
45
Interstitial granulomatous dermatitis with prominent neutrophil infiltration. ( 26566699 )
2015
46
Interstitial Granulomatous Dermatitis as the Initial Manifestation of Myeloma. ( 26039702 )
2015
47
Interstitial granulomatous dermatitis: a characteristic histological pattern with variable clinical manifestations. ( 26755914 )
2015
48
Granulomatous Dermatitis as a Cutaneous Manifestation of Hematologic Disorders: The First Case Associated With Polycythemia Vera and a New Case Associated With Myelodysplasia. ( 26703820 )
2015
49
Granulomatous dermatitis in a 29-year-old man from Bangladesh. ( 26882390 )
2015
50
Interstitial granulomatous dermatitis due to borreliosis. ( 25851752 )
2015

Variations for Granulomatous Dermatitis

Expression for Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for Granulomatous Dermatitis

GO Terms for Granulomatous Dermatitis

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.57 BRAF TNF
2 activation of MAPK activity GO:0000187 9.56 NOD2 TNF
3 kidney development GO:0001822 9.55 ACE FOXC1
4 regulation of inflammatory response GO:0050727 9.54 NOD2 TNF
5 positive regulation of gene expression GO:0010628 9.54 BRAF FOXC1 TNF
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.52 BRAF TNF
7 cellular response to organic cyclic compound GO:0071407 9.51 NOD2 TNF
8 positive regulation of JNK cascade GO:0046330 9.49 NOD2 TNF
9 positive regulation of MAP kinase activity GO:0043406 9.48 NOD2 TNF
10 JNK cascade GO:0007254 9.46 NOD2 TNF
11 positive regulation of interleukin-6 production GO:0032755 9.43 NOD2 TNF
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.4 NOD2 TNF
13 negative regulation of mitotic cell cycle GO:0045930 9.32 FOXC1 TNF
14 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.26 NOD2 TNF
15 blood vessel remodeling GO:0001974 9.16 ACE FOXC1
16 positive regulation of interleukin-8 production GO:0032757 8.96 NOD2 TNF
17 positive regulation of ERK1 and ERK2 cascade GO:0070374 8.8 BRAF NOD2 TNF

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 8.62 ACE BRAF

Sources for Granulomatous Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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