MCID: GRN003
MIFTS: 32

Granulomatous Dermatitis

Categories: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

MalaCards integrated aliases for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 12 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4397
NCIt 50 C3505
UMLS 70 C0743086

Summaries for Granulomatous Dermatitis

MalaCards based summary : Granulomatous Dermatitis is related to dermatitis and iridocyclitis. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Tight junction and Yersinia infection. Affiliated tissues include skin, cerebellum and prostate.

Related Diseases for Granulomatous Dermatitis

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
# Related Disease Score Top Affiliating Genes
1 dermatitis 31.3 TNF NOD2 CD8A CD4
2 iridocyclitis 30.3 TNF CD4 ACE
3 lymphadenitis 30.3 TNF NOD2 CD4
4 chickenpox 30.2 TNF CD8A CD4
5 colitis 30.2 TNF NOD2 CD4 BRAF
6 herpes zoster 30.2 TNF CD8A CD4
7 exanthem 30.2 TNF CD8A CD4 ACE
8 cellulitis 30.1 TNF CD8A CD4
9 sarcoidosis 1 30.1 TNF NOD2 CD8A CD4 ACE
10 bacterial infectious disease 30.0 TNF NOD2 CD4
11 connective tissue disease 30.0 TNF CD8A CD4 ACE
12 synovitis 30.0 TNF CD68 CD163
13 panniculitis 29.9 TNF CD8A CD4 BRAF
14 urticaria 29.9 TNF CD4 ACE
15 secondary syphilis 29.8 CD8A CD4
16 tuberculoid leprosy 29.8 TNF CD4 CD1B
17 multicentric reticulohistiocytosis 29.8 CD68 CD1E
18 blepharitis 29.7 TNF CD8A CD4
19 histiocytosis 29.6 TNF CD1C CD163 BRAF
20 langerhans cell histiocytosis 29.5 CD68 CD1C CD163 BRAF
21 granuloma annulare 29.5 TNF CD68 CD4 CD1E CD1C CD1B
22 syphilis 29.5 TNF CD8A CD4 ACE
23 skin disease 29.4 TNF CD8A CD4 CD1C CD163
24 lichen nitidus 29.3 CD1E CD1C CD1B
25 necrobiosis lipoidica 29.2 TNF CD68 CD1E CD1B CD163
26 mycobacterium tuberculosis 1 28.7 TNF NOD2 CD8A CD4 CD1C CD1B
27 leprosy 3 28.1 TNF NOD2 CD8A CD68 CD4 CD1E
28 interstitial granulomatous dermatitis with arthritis 11.4
29 blau syndrome 11.1
30 vasculitis 10.5
31 sigmoid disease 10.4 TNF NOD2
32 gastroduodenal crohn's disease 10.4 TNF NOD2
33 pouchitis 10.4 TNF NOD2
34 anterior scleritis 10.3 TNF ACE
35 posterior scleritis 10.3 TNF ACE
36 arthritis 10.3
37 hypereosinophilic syndrome 10.3
38 orofacial granulomatosis 10.3 TNF NOD2
39 melkersson-rosenthal syndrome 10.3 TNF ACE
40 chemical colitis 10.3 TNF NOD2
41 posterior urethral valves 10.3 TNF ACE
42 systemic lupus erythematosus 10.3
43 rheumatoid arthritis 10.3
44 lupus erythematosus 10.3
45 ileocolitis 10.3 TNF NOD2
46 anorectal stricture 10.3 TNF NOD2
47 heart aneurysm 10.3 TNF ACE
48 spondylarthropathy 10.3 TNF CD163
49 myelodysplastic syndrome 10.3
50 rheumatoid arthritis interstitial lung disease 10.3 TNF CD4

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to Granulomatous Dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

Drugs & Therapeutics for Granulomatous Dermatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

MalaCards organs/tissues related to Granulomatous Dermatitis:

40
Skin, Cerebellum, Prostate, Myeloid, Neutrophil

Publications for Granulomatous Dermatitis

Articles related to Granulomatous Dermatitis:

(show top 50) (show all 458)
# Title Authors PMID Year
1
Reactive granulomatous dermatitis as a histological pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: a study of 52 patients. 61
33098595 2021
2
Case of systemic sarcoidosis involving skin lesions that exhibited histological evidence of interstitial granulomatous dermatitis accompanied by widespread thrombophlebitis. 61
33502027 2021
3
Palisaded neutrophilic granulomatous dermatitis, interstitial granulomatous dermatitis and IgA vasculitis associated with incomplete Sjögren's syndrome. 61
33406284 2021
4
Multiple dermatomal granulomatous dermatitis concurring with herpes zoster. 61
33580911 2021
5
Strontium citrate associated drug reaction with eosinophilia and systemic symptoms syndrome with granulomatous dermatitis. 61
33778142 2021
6
Mycobacterium salmoniphilum and M. chelonae in Captive Populations of Chinook Salmon. 61
33780059 2021
7
Palisaded neutrophilic and granulomatous dermatitis in a patient with rheumatoid arthritis. 61
32949132 2021
8
A novel mutation in early-onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes. 61
33602264 2021
9
Histopathological Spectrum and Immunophenotypic Characterization of Symmetrical Drug-Related Intertriginous and Flexural Exanthema. 61
32618703 2021
10
Histopathological evaluation of cutaneous reactions to tattoos: Study at a tertiary care center. 61
33527478 2021
11
Treatment of granuloma annulare and related granulomatous diseases with sulphasalazine: a series of 16 cases. 61
32216136 2021
12
Etanercept-induced palisaded neutrophilic granulomatous dermatitis. 61
33279312 2021
13
Non-tuberculous Mycobacterial Granulomatous Dermatitis in an African Pygmy Hedgehog (Atelerix albiventris). 61
33494903 2021
14
Palisaded neutrophilic and granulomatous dermatitis following a long-standing monoclonal gammopathy: A case report. 61
33628445 2021
15
Unintended Self-Inoculation with Bovine Paratuberculosis Vaccine Causing Granulomatous Dermatitis Positive for Acid-Fast Bacilli. 61
33461427 2021
16
Localized reactive granulomatous dermatitis secondary to erythema migrans. 61
33294552 2020
17
Diagnostic Utility of Biplex/Multiplex Polymerase Chain Reaction in Infectious Granulomatous Dermatitis in North Indian Population. 61
33395043 2020
18
Histopathologic Characterization of Mogamulizumab-associated Rash. 61
32976123 2020
19
Equine Idiopathic Systemic Granulomatous Disease With Manifestation in the Cerebellum Associated With Equid Gammaherpesvirus 2. 61
33077072 2020
20
Interstitial granulomatous dermatitis following tocilizumab, a paradoxical reaction? 61
32816393 2020
21
Ophidiomycosis in Red Cornsnakes (Pantherophis guttatus): Potential Roles of Brumation and Temperature on Pathogenesis and Transmission. 61
32862796 2020
22
Treatment of recalcitrant reactive granulomatous dermatitis: Granuloma annulare subtype with etanercept. 61
32713130 2020
23
Interstitial granulomatous dermatitis as primary manifestation of marginal zone lymphoma. 61
32662885 2020
24
Eosinophilic cellulitis successfully treated with Methotrexate. 61
32585743 2020
25
In vivo cutaneous antinuclear antibody positivity in palisaded neutrophilic and granulomatous dermatitis. 61
32335926 2020
26
Lichenoid granulomatous dermatitis as a tuberculid in association with spondylitis due to Mycobacterium tuberculosis. 61
32352174 2020
27
Caprine nodular thelitis due to Mycobacterium uberis: A series of 26 cases in 11 dairy goat farms in Western France. 61
32540717 2020
28
The Investigation of the Association of Cutaneous Leishmaniasis in Biopsy Specimens of the Patients with Granulomatous Disease and Skin Cancer Using the Molecular Method. 61
33082794 2020
29
Metastatic Crohn Disease: A Clinicohistological Appraisal From a Tertiary Care Center in India. 61
31693502 2020
30
Cutaneous microsporidiosis in an immunosuppressed patient. 61
32125011 2020
31
Three Patterns of Cutaneous Involvement in Granulomatosis with Polyangiitis. 61
32455005 2020
32
Sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) in adult dogs: a retrospective analysis of 90 cases (2004-2018). 61
31789433 2020
33
Rubella Vaccine Persistence Within Cutaneous Granulomas in Common Variable Immunodeficiency Disorder. 61
31899704 2020
34
Herpes zoster granulomatous dermatitis in metastatic lung cancer treated with nivolumab: A case report. 61
32141197 2020
35
Clinical and histologic presentation of pediatric reactive granulomatous dermatitis. 61
32115758 2020
36
Interstitial Granulomatous Dermatitis and Tocilizumab: Is This Treatment Useful for This Skin Condition? 61
32248944 2020
37
A Rare Clinical Presentation of Metastatic Crohn's Disease. 61
32467818 2020
38
Mycobacterium mageritense tattoo infection: a known complication with a novel species. 61
32621684 2020
39
Molecular and Biological Characterization of a Cervidpoxvirus Isolated From Moose with Necrotizing Dermatitis. 61
32096438 2020
40
Idiopathic lichenoid and granulomatous dermatitis. 61
32129050 2020
41
Blau Syndrome and Early-Onset Sarcoidosis: A Six Case Series and Review of the Literature. 61
32637927 2020
42
Granulomatous Dermatitis and Systemic Disease: An Association to Consider. 61
33062676 2020
43
Interstitial granulomatous dermatitis and granulomatous arteritis in the setting of PD-1 inhibitor therapy for metastatic melanoma. 61
31390071 2020
44
Palisaded Neutrophilic and Granulomatous Dermatitis in a Patient with Granulomatosis with Polyangiitis. 61
32308576 2020
45
Truncal necrobiosis lipoidica diabeticorum: A first case report. 61
33197774 2020
46
A Novel Exophiala Species Associated With Disseminated Granulomatous Inflammation in a Captive Eastern Hellbender (Cryptobranchus alleganiensis alleganiensis). 61
32083105 2020
47
Dermoscopy of Mycobacterium marinum Skin infection: A Challenging Diagnosis. 61
31969244 2019
48
Immune checkpoint inhibitors and the development of granulomatous reactions. 61
30092327 2019
49
Lichenoid granulomatous dermatitis revisited: A retrospective case series. 61
31378565 2019
50
Palisaded Neutrophilic Granulomatous Dermatitis Leading to Diagnosis of Hodgkin Lymphoma: Report of Rare Case and Literature Review of Paraneoplastic Granulomatous Dermatitides. 61
30921008 2019

Variations for Granulomatous Dermatitis

Expression for Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for Granulomatous Dermatitis

GO Terms for Granulomatous Dermatitis

Cellular components related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.96 TNF NOD2 CD8A CD68 CD4 CD1C
2 membrane GO:0016020 9.93 TNF SPATA46 NOD2 CD8A CD68 CD4
3 integral component of plasma membrane GO:0005887 9.85 TNF CD8A CD4 CD1E CD1C CD163
4 endosome GO:0005768 9.72 CD68 CD1E CD1C CD1B ACE
5 lysosome GO:0005764 9.35 CD68 CD1E CD1C CD1B ACE
6 external side of plasma membrane GO:0009897 9.23 TNF CD8A CD4 CD1E CD1C CD1B

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 NOD2 CD8A CD4 CD1E CD1C CD1B
2 adaptive immune response GO:0002250 9.77 CD8A CD4 CD1E CD1C CD1B
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 TNF NOD2 CD4 BRAF
4 cellular response to lipopolysaccharide GO:0071222 9.63 TNF NOD2 CD68
5 immune response GO:0006955 9.63 TNF CD8A CD4 CD1E CD1C CD1B
6 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.48 TNF NOD2
7 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.43 TNF NOD2
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.43 CD1E CD1C CD1B
9 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.13 CD1E CD1C CD1B
10 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.8 CD1E CD1C CD1B

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.33 CD1E CD1C CD1B
2 mitogen-activated protein kinase kinase binding GO:0031434 9.26 BRAF ACE
3 exogenous lipid antigen binding GO:0030884 9.13 CD1E CD1C CD1B
4 endogenous lipid antigen binding GO:0030883 8.8 CD1E CD1C CD1B

Sources for Granulomatous Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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