MCID: GRN003
MIFTS: 35

Granulomatous Dermatitis

Categories: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

MalaCards integrated aliases for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4397
NCIt 49 C3505
UMLS 71 C0743086

Summaries for Granulomatous Dermatitis

MalaCards based summary : Granulomatous Dermatitis is related to vasculitis and uveitis. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response NFAT in immune response. Affiliated tissues include neutrophil, skin and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Granulomatous Dermatitis

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 443)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.9 TNFRSF1B TNF CD40LG
2 uveitis 30.7 TNFRSF1B TNF NOD2
3 lymphadenitis 30.1 TNF NOD2 CD4
4 pyoderma 30.0 TNFRSF1B TNF NOD2
5 spondylitis 30.0 TNFRSF1B TNF NOD2
6 erythema elevatum diutinum 30.0 TNFRSF1B CD40LG
7 cellulitis 29.9 TNF CD40LG CD4
8 secondary syphilis 29.7 CD40LG CD4
9 granuloma annulare 29.6 TNFRSF1B CD68 CD1B CD163
10 polyneuropathy 29.6 TNF CD40LG ACE
11 crohn's disease 29.6 TNFRSF1B TNF NOD2 CD4
12 chickenpox 29.5 TNFRSF1B TNF CD40LG CD4
13 histiocytosis 29.5 TNF CD163 BRAF
14 tuberculoid leprosy 29.5 CD4 CD1B
15 exanthem 29.5 TNFRSF1B TNF CD40LG CD4 ACE
16 psoriatic arthritis 29.5 TNFRSF1B TNF NOD2 CD40LG
17 vascular disease 29.5 TNF CD40LG CD4 ACE
18 syphilis 29.5 CD40LG CD4 ACE
19 herpes zoster 29.4 TNFRSF1B TNF CD40LG CD4
20 common variable immunodeficiency 29.4 TNFRSF1B TNF NOD2 CD40LG
21 synovitis 29.4 TNF CD68 CD163
22 langerhans cell histiocytosis 29.3 CD68 CD163 BRAF
23 connective tissue disease 29.3 TNFRSF1B TNF CD40LG CD4 ACE
24 sarcoidosis 1 29.2 TNFRSF1B TNF NOD2 CD40LG CD4 ACE
25 necrobiosis lipoidica 29.2 TNFRSF1B TNF CD68 CD163
26 bacterial infectious disease 29.2 TNF NOD2 CD40LG CD4
27 collagen disease 29.2 TNF CD40LG CD4 ACE
28 iridocyclitis 29.1 TNFRSF1B TNF CD40LG CD4 ACE
29 granulomatosis with polyangiitis 29.1 TNFRSF1B TNF CD40LG CD4
30 leprosy 3 28.8 TNF NOD2 CD40LG CD4 CD1B
31 inflammatory bowel disease 28.8 TNFRSF1B TNF NOD2 CD40LG CD163 ACE
32 skin disease 28.6 TNFRSF1B TNF CD40LG CD4 CD163
33 spondyloarthropathy 1 28.6 TNFRSF1B TNF NOD2 CD40LG CD163
34 interstitial granulomatous dermatitis with arthritis 12.7
35 blau syndrome 11.6
36 dermatitis 11.0
37 arthritis 10.5
38 histoplasmosis pericarditis 10.5 TNF ACE
39 subacute cutaneous lupus erythematosus 10.5 TNF ACE
40 posterior scleritis 10.5 TNF ACE
41 gastroduodenal crohn's disease 10.4 TNF NOD2
42 orofacial granulomatosis 10.4 TNF NOD2
43 posterior urethral valves 10.4 TNF ACE
44 melkersson-rosenthal syndrome 10.4 TNF ACE
45 chemical colitis 10.4 TNF NOD2
46 autoimmune disease 10.4
47 rheumatoid arthritis interstitial lung disease 10.4 TNFRSF1B TNF
48 juvenile ankylosing spondylitis 10.4 TNFRSF1B TNF
49 sarcoid meningitis 10.4 TNFRSF1B ACE
50 ileocolitis 10.4 TNF NOD2

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to Granulomatous Dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

GenomeRNAi Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.36 ACE CD40LG NOD2 TNF TNFRSF1B
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.36 ACE BRAF CD40LG NOD2 TNF TNFRSF1B

MGI Mouse Phenotypes related to Granulomatous Dermatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 BRAF CD163 CD4 CD40LG FOXC1 NOD2
2 hematopoietic system MP:0005397 9.81 ACE BRAF CD163 CD4 CD40LG CD68
3 digestive/alimentary MP:0005381 9.8 BRAF CD4 FOXC1 NOD2 TNF TNFRSF1B
4 endocrine/exocrine gland MP:0005379 9.8 ACE BRAF CD4 CD40LG FOXC1 TNF
5 immune system MP:0005387 9.61 ACE BRAF CD163 CD4 CD40LG CD68
6 skeleton MP:0005390 9.17 BRAF CD40LG CD68 FOXC1 NOD2 TNF

Drugs & Therapeutics for Granulomatous Dermatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

MalaCards organs/tissues related to Granulomatous Dermatitis:

40
Neutrophil, Skin, T Cells, Lung, B Cells, Thyroid, Myeloid

Publications for Granulomatous Dermatitis

Articles related to Granulomatous Dermatitis:

(show top 50) (show all 416)
# Title Authors PMID Year
1
Rubella Vaccine Persistence Within Cutaneous Granulomas in Common Variable Immunodeficiency Disorder. 61
31899704 2020
2
Interstitial granulomatous dermatitis and granulomatous arteritis in the setting of PD-1 inhibitor therapy for metastatic melanoma. 61
31390071 2020
3
Sterile granulomatous dermatitis and lymphadenitis (juvenile cellulitis) in adult dogs: a retrospective analysis of 90 cases (2004-2018). 61
31789433 2019
4
Dermoscopy of Mycobacterium marinum Skin infection: A Challenging Diagnosis. 61
31969244 2019
5
Lichenoid granulomatous dermatitis revisited: A retrospective case series. 61
31378565 2019
6
Palisaded Neutrophilic Granulomatous Dermatitis Leading to Diagnosis of Hodgkin Lymphoma: Report of Rare Case and Literature Review of Paraneoplastic Granulomatous Dermatitides. 61
30921008 2019
7
Immune checkpoint inhibitors and the development of granulomatous reactions. 61
30092327 2019
8
Blau syndrome with a rare mutation in exon 9 of NOD2 gene. 61
31556326 2019
9
Metastatic Crohn Disease: A Clinicohistological Appraisal From a Tertiary Care Center in India. 61
31693502 2019
10
Lichenoid reaction with granulomatous stomatitis: A retrospective histologic study of 47 patients. 61
31228223 2019
11
Skin and superficial soft tissue neoplasms with multinucleated giant cells: Clinical, histologic, phenotypic, and molecular differentiating features. 61
31306855 2019
12
Reactive granulomatous dermatitis in association with topiramate ingestion. 61
30687955 2019
13
Infliximab reduces activated myeloid dendritic cells, different macrophage subsets and CXCR3-positive cells in granuloma annulare. 61
31290564 2019
14
Intralesional Steroids for the Management of Periorificial Granulomatous Dermatitis 61
31524997 2019
15
Cutaneous schistosomiasis and leishmaniasis coinfection: a case report. 61
30801816 2019
16
Role of Histopathology in the Diagnosis of Cutaneous Leishmaniasis: A Case-Control Study in Sri Lanka. 61
31335408 2019
17
Palisaded neutrophilic granulomatous dermatitis and its associations with autoimmune diseases. 61
31456573 2019
18
Sarcoidosis with Multiorgan Involvement and Cutaneous Manifestations after Colonic Adenocarcinoma Resection. 61
31293305 2019
19
Topiramate-induced reactive granulomatous dermatitis. 61
31193974 2019
20
Epidemiology, risk factors, and outcomes of adult cutaneous non-tuberculous mycobacterial infection over a 10-year period in Singapore. 61
30585309 2019
21
Palisaded neutrophilic and granulomatous dermatitis in a patient with chronic myelomonocytic leukaemia. 61
30773700 2019
22
Perforating Granuloma Annulare Appearing as a Psoriasiform Lesion. 61
31543770 2019
23
The role of biologics in the treatment of chronic granuloma annulare. 61
30618205 2019
24
Dermoscopy of palisaded neutrophilic and granulomatous dermatitis. 61
30666710 2019
25
A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia. 61
30997066 2019
26
Bowel-associated dermatosis arthritis syndrome and palisading neutrophilic granulomatous dermatitis as presentation of ulcerative colitis. 61
30924626 2019
27
Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient. 61
30870808 2019
28
Leprosy in a Midwestern Dermatology Clinic: Report of 9 Patients. 61
30799052 2019
29
Reactions to Gudair® vaccination identified in sheep used for biomedical research. 61
30761525 2019
30
BRAF Inhibitor-Associated Granulomatous Dermatitis: A Report of 3 Cases. 61
30601209 2019
31
The histological spectrum of talimogene laherparepvec (TVEC) injections-Neutrophilic and chronic granulomatous dermatitis. 61
30414194 2019
32
Cutaneous gummatous tuberculosis in a kidney transplant patient. 61
30893397 2019
33
Cutaneous Leishmaniasis: Contribution of Routine Histopathology in Unexpected Encounters. 61
30334828 2019
34
Necrotizing Granulomatous Dermatitis and Panniculitis Masquerading as T Cell Lymphoma. 61
31904333 2019
35
Educational Case: Granulomatous Dermatitis. 61
31897421 2019
36
Granuloma multiforme: an uncommon differential for leprosy. 61
30286700 2019
37
Advances in Inflammatory Granulomatous Skin Diseases. 61
30466688 2019
38
Cobimetinib- and vemurafenib-induced granulomatous dermatitis and erythema induratum: A case report. 61
31205706 2019
39
Rheumatoid-nodule-like cutaneous granuloma associated with recombinase activating gene 1-deficient severe combined immunodeficiency: A rare case. 61
30203448 2018
40
Palisaded neutrophilic and granulomatous dermatitis associated with systemic lupus erythematosus: possible involvement of CD163+ M2 macrophages in two cases, and a review of published works. 61
30376790 2018
41
Granulomatous dermatitis secondary to vemurafenib in a child with Langerhans cell histiocytosis. 61
30216522 2018
42
Granuloma Annulare-Like Granulomatous Reaction to Red Tattoo Pigment. 61
29658308 2018
43
Image Gallery: Granulomatous dermatitis due to infection with the chlorophyllic green alga Desmodesmus. 61
30318802 2018
44
A Case of Prototheca zopfii Genotype 1 Infection in a Dog (Canis lupus familiaris). 61
29872935 2018
45
Granulomatous dermatitis as a postherpetic isotopic response in immunocompromised patients: A report of 5 cases. 61
30246119 2018
46
Palisaded neutrophilic and granulomatous dermatitis associated with ledipasvir/sofosbuvir. 61
30246134 2018
47
Subclinical granulomas in benign skin lesions heralding the onset of BRAF and MEK inhibitor-associated granulomatous dermatitis in a patient with metastatic melanoma. 61
30167445 2018
48
Granulomatous dermatitis associated with ipilimumab therapy (ipilimumab associated granulomatous dermatitis). 61
29704281 2018
49
Paraneoplastic granulomatous dermatitis in a patient with Hodgkin's disease: a diagnostic pitfall. 61
30100570 2018
50
First report of nodular skin lesions caused by Mycobacterium nebraskense in a 9-year-old cat. 61
30186616 2018

Variations for Granulomatous Dermatitis

Expression for Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for Granulomatous Dermatitis

Pathways related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 TNFRSF1B TNF NOD2 CD40LG CD4 BRAF
2
Show member pathways
12.34 TNFRSF1B TNF CD40LG CD4
3
Show member pathways
11.95 TNFRSF1B TNF CD40LG CD4 BRAF
4 11.66 TNFRSF1B TNF NOD2
5 11.58 TNF CD4 CD1B
6 11.37 TNF CD4 CD163
7
Show member pathways
11.3 TNFRSF1B TNF CD40LG
8 11.18 TNF CD68 CD163
9 10.99 TNF CD68 CD4 CD163
10 10.86 TNF NOD2
11 10.66 TNF CD68

GO Terms for Granulomatous Dermatitis

Cellular components related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10 TNFRSF1B TNF SPATA46 NOD2 CD68 CD40LG
2 plasma membrane GO:0005886 9.65 TNFRSF1B TNF NOD2 CD68 CD40LG CD4
3 cell surface GO:0009986 9.55 TNF NOD2 CD40LG CD4 CD1B
4 external side of plasma membrane GO:0009897 9.1 TNF CD40LG CD4 CD1B CD163 ACE

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 TNFRSF1B TNF CD40LG CD163
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.61 TNF NOD2 CD40LG
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.5 TNFRSF1B TNF CD40LG
4 regulation of blood vessel diameter GO:0097746 9.46 FOXC1 ACE
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.46 TNF NOD2 CD4 BRAF
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.4 TNFRSF1B TNF
7 immune response GO:0006955 9.35 TNFRSF1B TNF CD40LG CD4 CD1B
8 regulation of immunoglobulin secretion GO:0051023 9.26 TNF CD40LG
9 cellular response to lipopolysaccharide GO:0071222 8.92 TNFRSF1B TNF NOD2 CD68

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 8.62 BRAF ACE

Sources for Granulomatous Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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