MCID: GRN009
MIFTS: 38

Granulomatous Hepatitis

Categories: Gastrointestinal diseases, Endocrine diseases

Aliases & Classifications for Granulomatous Hepatitis

MalaCards integrated aliases for Granulomatous Hepatitis:

Name: Granulomatous Hepatitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2239
NCIt 50 C27015
SNOMED-CT 68 86514004
ICD10 33 K75.3
UMLS 73 C0235369

Summaries for Granulomatous Hepatitis

MalaCards based summary : Granulomatous Hepatitis is related to interstitial nephritis and brucellosis. An important gene associated with Granulomatous Hepatitis is ZBTB24 (Zinc Finger And BTB Domain Containing 24), and among its related pathways/superpathways are Akt Signaling and Pathways in cancer. Affiliated tissues include liver, t cells and testes, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Granulomatous Hepatitis

Diseases related to Granulomatous Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 interstitial nephritis 30.4 ACE CRP PDCD1
2 brucellosis 30.3 CD40LG CRP IL4
3 toxoplasmosis 30.2 CD40LG CD79A IL4
4 schistosomiasis 30.2 CD40LG CD79A IL4
5 cholangitis 30.0 CD40LG CRP GGT1
6 pleuropneumonia 30.0 CD40LG CD79A GGT1
7 vasculitis 29.7 CD40LG CD79A CRP IFNA2 TNFRSF1B
8 rheumatoid arthritis 29.1 CD40LG CD79A CRP IL4 TNFRSF1B
9 systemic lupus erythematosus 28.3 CD40LG CD79A CRP FASLG IL4 PDCD1
10 selective igg deficiency disease 11.0 CD40LG CD79A
11 c1q nephropathy 11.0 CD40LG CD79A
12 meningovascular neurosyphilis 11.0 CD40LG CD79A
13 alpha chain disease 11.0 CD40LG CD79A
14 brill-zinsser disease 11.0 CD40LG CD79A
15 exudative glomerulonephritis 11.0 CD40LG CD79A
16 cork-handlers' disease 11.0 CD40LG CD79A
17 salpingo-oophoritis 11.0 CD40LG CD79A
18 early yaws 11.0 CD40LG CD79A
19 ventilation pneumonitis 11.0 CD40LG CD79A
20 chronic interstitial cystitis 11.0 CD40LG CD79A
21 axillary adenitis 11.0 CD40LG CD79A
22 cryofibrinogenemia 11.0 CD40LG CD79A
23 loeffler syndrome 10.9 ACE CD40LG
24 trichostrongyloidiasis 10.9 CD40LG CD79A
25 subacute bacterial endocarditis 10.9 CD40LG CD79A
26 heterophyiasis 10.9 CD40LG CD79A
27 immunoglobulin g deficiency 10.9 CD40LG CD79A
28 orbital granuloma 10.9 CD40LG CD79A
29 transient hypogammaglobulinemia of infancy 10.9 CD40LG CD79A
30 hyperglobulinemic purpura 10.9 CD40LG CD79A
31 gastroduodenitis 10.9 CD40LG CD79A
32 bacterial conjunctivitis 10.9 CD40LG CD79A
33 heavy chain disease 10.8 CD40LG CD79A
34 spinocerebellar ataxia, autosomal recessive 10 10.8 CD40LG CD79A IFNA2
35 phlebotomus fever 10.8 CD40LG CD79A IFNA2
36 ophthalmia neonatorum 10.8 CD40LG CD79A
37 acalculous cholecystitis 10.8 CD40LG CRP
38 acute maxillary sinusitis 10.8 CD40LG CD79A CRP
39 hypersensitivity vasculitis 10.8 CD40LG CD79A CRP
40 intussusception 10.8 CD40LG CD79A CRP
41 cryoglobulinemia 10.8 CD40LG CD79A IFNA2
42 cerebral arteritis 10.8 CD40LG CD79A
43 intestinal tuberculosis 10.8 CD79A CRP
44 hypersensitivity reaction type iii disease 10.8 CD40LG CD79A CRP
45 pyelitis 10.8 CD40LG CD79A CRP
46 immunodeficiency-centromeric instability-facial anomalies syndrome 10.8 CD40LG CD79A ZBTB24
47 endocardium disease 10.8 CD40LG CD79A CRP
48 mononeuritis multiplex 10.8 CD40LG CRP
49 selective immunoglobulin deficiency disease 10.8 CD40LG CD79A
50 lymph node disease 10.8 CD40LG CD79A CRP

Graphical network of the top 20 diseases related to Granulomatous Hepatitis:



Diseases related to Granulomatous Hepatitis

Symptoms & Phenotypes for Granulomatous Hepatitis

MGI Mouse Phenotypes related to Granulomatous Hepatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.22 FASLG ACE GGT1 ACTA1 AVP IL4
2 hematopoietic system MP:0005397 10.11 FASLG ACE GGT1 IL4 CD40LG ITGA2B
3 immune system MP:0005387 10.03 FASLG ACE GGT1 IL4 CD40LG ITGA2B
4 mortality/aging MP:0010768 9.77 FASLG ACE ACTA1 GGT1 AVP IL4
5 liver/biliary system MP:0005370 9.7 FASLG ACE ACTA1 IL4 CD79A PDCD1
6 renal/urinary system MP:0005367 9.28 FASLG ACE GGT1 AVP IL4 CD40LG

Drugs & Therapeutics for Granulomatous Hepatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Hepatitis

Genetic Tests for Granulomatous Hepatitis

Anatomical Context for Granulomatous Hepatitis

MalaCards organs/tissues related to Granulomatous Hepatitis:

41
Liver, T Cells, Testes, Lung, Heart, Smooth Muscle

Publications for Granulomatous Hepatitis

Articles related to Granulomatous Hepatitis:

(show top 50) (show all 216)
# Title Authors Year
1
Massive hemolysis complicating acute granulomatous hepatitis. ( 29675610 )
2018
2
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. ( 28882937 )
2017
3
Acute granulomatous hepatitis in an immunosuppressed patient secondary to Q fever. ( 28549166 )
2017
4
Granulomatous hepatitis in a healthy adult after bacillus Calmette-GuAcrin injection into a plantar wart. ( 29159252 )
2017
5
Hepatobiliary and Pancreatic: Granulomatous hepatitis due to disseminated bacillus Calmette-GuAcrin disease. ( 28845587 )
2017
6
Allopurinol-Induced Granulomatous Hepatitis: A Case Report and Review of Literature. ( 29082266 )
2017
7
Granulomatous hepatitis: a rare primary manifestation of disseminated histoplasmosis in a renal transplant recipient. ( 28617878 )
2017
8
A case of fever of unknown origin due to granulomatous hepatitis due to tubercular etiology. ( 27728391 )
2016
9
A rare case of idiopathic granulomatous hepatitis presenting as tumoral lesion detected by 18F-FDG-PET/CT. ( 26626647 )
2016
10
Vemurafenib-induced granulomatous hepatitis. ( 27335285 )
2016
11
X-linked Inhibitor of Apoptosis Complicated by Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) and Granulomatous Hepatitis. ( 27492372 )
2016
12
Angiostrongylus vasorum Causing Severe Granulomatous Hepatitis with Concurrent Multiple Acquired PSS. ( 26355583 )
2015
13
Granulomatous hepatitis with hepatic mass lesions and a response to infliximab. ( 26134699 )
2015
14
A case of acute interstitial nephritis and granulomatous hepatitis induced by ingesting quinine. ( 28509275 )
2015
15
Histoplasmosis presenting as granulomatous hepatitis: case report and review of the literature. ( 25013413 )
2014
16
A rare case of fever of unknown origin. Idiopathic granulomatous hepatitis. ( 24825816 )
2014
17
D-penicillamine-induced granulomatous hepatitis in brown Norway rats. ( 24771069 )
2014
18
Co-occurrence of Idiopathic Granulomatous Hepatitis and Primary Biliary Cirrhosis. ( 25108519 )
2014
19
A 60-year-old man with fever, cholestasis and granulomatous hepatitis. ( 24525009 )
2014
20
Granulomatous hepatitis secondary to histoplasma infection after treatment with infliximab. ( 25379301 )
2013
21
Concurrent granulomatous hepatitis, pneumonitis and sepsis as a complication of intravesical BCG immunotherapy. ( 24114600 )
2013
22
Non-Tuberculous Mycobacterium: A Rare Cause of Granulomatous Hepatitis. ( 27785230 )
2013
23
Isolated granulomatous hepatitis-A histopathological surprise mimicking cholangiocarcinoma in ulcerative colitis. ( 23396747 )
2013
24
Granulomatous hepatitis as a rare complication of Bacillus Calmette-Gurin vaccination. ( 24413871 )
2013
25
Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin. ( 23293205 )
2013
26
Albendazole-induced granulomatous hepatitis: a case report. ( 23889970 )
2013
27
Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. ( 22269175 )
2012
28
Multiple organ failure and granulomatous hepatitis following intravesical bacillus Calmette-GuAcrin instillation. ( 23189546 )
2012
29
A young adult presenting with granulomatous hepatitis and nephrotic syndrome: A case report. ( 23095309 )
2012
30
Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue. ( 22855374 )
2012
31
Granulomatous hepatitis after intravesical bacillus Calmette-GuAcrin treatment. ( 20854217 )
2011
32
Granulomatous hepatitis, choroiditis and aortoduodenal fistula complicating intravesical Bacillus Calmette-GuAcrin therapy: Case report. ( 21961922 )
2011
33
Granulomatous hepatitis from disseminated Mycobacterium bovis infection: shift of an intended local towards a detrimental systemic infection. ( 21922888 )
2011
34
Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report. ( 20594295 )
2010
35
Hypercalcemia worsened by the use of furosemide in a patient suffering from allopurinol-induced granulomatous hepatitis. ( 20361854 )
2010
36
Abnormal liver enzymes in a patient with Crohn's disease, psoriatic arthritis, and recurrent pancreatitis. Answer to the clinical challenges and images in GI question: image 5: Idiopathic granulomatous hepatitis. ( 20600067 )
2010
37
"Ohio River valley fever" presenting as isolated granulomatous hepatitis: a case report. ( 19434026 )
2009
38
Granulomatous hepatitis, perihepatic lymphadenopathies, and autoantibody positivity: an unusual association in a child with hepatitis C. ( 18509673 )
2009
39
Cyclophosphamide therapy in granulomatous hepatitis: cure or culprit? ( 19262358 )
2009
40
Peritoneal tuberculosis and granulomatous hepatitis secondary to treatment of bladder cancer with Bacillus Calmette-GuAcrin. ( 19368735 )
2009
41
Frequency and predictive factors of granulomatous hepatitis in patients with peritoneal tuberculosis. ( 19927783 )
2009
42
The use of infliximab in a patient with idiopathic granulomatous hepatitis. ( 21686858 )
2009
43
Granulomatous hepatitis following open heart surgery with cardiopulmonary bypass. ( 19320320 )
2008
44
Enhanced expression of transforming growth factor-beta 1 in inflammatory cells, alpha-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice. ( 18178169 )
2008
45
Multifocal granulomatous hepatitis caused by Actinobacillus pleuropneumoniae serotype 2 in slaughter pigs. ( 18617183 )
2008
46
Granulomatous hepatitis: tuberculosis or not? ( 18241177 )
2008
47
Granulomatous hepatitis associated with etanercept therapy. ( 18260163 )
2008
48
Necrotizing granulomatous hepatitis in slaughtered broilers. ( 17626499 )
2007
49
BCG-related granulomatous hepatitis. ( 17491206 )
2007
50
Necrotizing granulomatous hepatitis as an unusual manifestation of Lyme disease. ( 17638077 )
2007

Variations for Granulomatous Hepatitis

Expression for Granulomatous Hepatitis

Search GEO for disease gene expression data for Granulomatous Hepatitis.

Pathways for Granulomatous Hepatitis

GO Terms for Granulomatous Hepatitis

Cellular components related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 ACE AVP CD40LG CRP FASLG IFNA2
2 extracellular space GO:0005615 9.65 ACE ACTA1 AVP CD40LG CRP EZR
3 membrane raft GO:0045121 9.55 CD79A EZR FASLG RIT2 TNFRSF1B
4 cell body GO:0044297 9.43 ACTA1 EZR RIT2
5 external side of plasma membrane GO:0009897 9.1 ACE CD40LG CD79A FASLG ITGA2B PDCD1

Biological processes related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.85 AVP CD40LG IL4 PDCD1 XIAP
2 regulation of signaling receptor activity GO:0010469 9.65 AVP CD40LG FASLG IFNA2 IL4
3 apoptotic process GO:0006915 9.63 AVP FASLG IFNA2 PDCD1 TNFRSF1B XIAP
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.54 AVP TNFRSF1B XIAP
5 zymogen activation GO:0031638 9.43 GGT1 GGT2
6 glutathione catabolic process GO:0006751 9.4 GGT1 GGT2
7 leukotriene D4 biosynthetic process GO:1901750 9.32 GGT1 GGT2
8 B cell proliferation GO:0042100 9.13 CD40LG CD79A IFNA2
9 B cell differentiation GO:0030183 8.92 CD40LG CD79A IFNA2 IL4

Molecular functions related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione hydrolase activity GO:0036374 8.96 GGT1 GGT2
2 cytokine activity GO:0005125 8.92 CD40LG FASLG IFNA2 IL4
3 protein binding GO:0005515 10.09 ACTA1 CD40LG CD79A CRP EZR FASLG

Sources for Granulomatous Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....