MCID: GRN009
MIFTS: 31

Granulomatous Hepatitis

Categories: Endocrine diseases, Gastrointestinal diseases

Aliases & Classifications for Granulomatous Hepatitis

MalaCards integrated aliases for Granulomatous Hepatitis:

Name: Granulomatous Hepatitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2239
NCIt 50 C27015
SNOMED-CT 68 86514004
ICD10 33 K75.3
UMLS 73 C0235369

Summaries for Granulomatous Hepatitis

MalaCards based summary : Granulomatous Hepatitis is related to vasculitis and hepatitis. An important gene associated with Granulomatous Hepatitis is ZBTB24 (Zinc Finger And BTB Domain Containing 24), and among its related pathways/superpathways are Reelin Pathway (Cajal-Retzius cells) and Remodeling of Adherens Junctions. Affiliated tissues include liver, lung and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Granulomatous Hepatitis

Diseases related to Granulomatous Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.2 CRP IFNA2
2 hepatitis 10.8
3 hepatitis a 10.3
4 q fever 10.1
5 cat-scratch disease 10.0
6 histoplasmosis 9.9
7 subdural empyema 9.9 CRP EZR
8 peptic ulcer perforation 9.9 CRP EZR
9 dysentery 9.8 CRP IFNA2
10 polyarteritis nodosa 9.8 CRP IFNA2
11 bladder cancer 9.8
12 arthritis 9.8
13 crohn's disease 9.8
14 lymphoma 9.8
15 interstitial nephritis 9.8
16 lyme disease 9.8
17 nephrotic syndrome 9.8
18 cholestasis 9.8
19 plantar wart 9.8
20 hepatitis c 9.8
21 secondary syphilis 9.8
22 syphilis 9.8
23 myocarditis 9.8
24 cholangitis 9.8
25 penile cancer 9.8 CRP IFNA2
26 behcet syndrome 9.8 CRP IFNA2
27 biliary cirrhosis, primary, 1 9.7
28 hepatocellular carcinoma 9.7
29 systemic lupus erythematosus 9.7
30 rheumatoid arthritis 9.7
31 temporal arteritis 9.7
32 sjogren syndrome 9.7
33 psoriatic arthritis 9.7
34 cholangiocarcinoma 9.7
35 acute leukemia 9.7
36 alcohol abuse 9.7
37 leukemia 9.7
38 neutropenia 9.7
39 primary biliary cirrhosis 9.7
40 thrombocytopenia 9.7
41 ulcerative colitis 9.7
42 colitis 9.7
43 giardiasis 9.7
44 brucellosis 9.7
45 choroiditis 9.7
46 uveitis 9.7
47 scrub typhus 9.7
48 coccidioidomycosis 9.7
49 schistosomiasis 9.7
50 lymphadenitis 9.7

Graphical network of the top 20 diseases related to Granulomatous Hepatitis:



Diseases related to Granulomatous Hepatitis

Symptoms & Phenotypes for Granulomatous Hepatitis

GenomeRNAi Phenotypes related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 IFNA2 ZBTB24
2 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 ZBTB24
3 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.64 ZBTB24
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.64 IFNA2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.64 ZBTB24
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.64 ZBTB24
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.64 ZBTB24
8 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.64 IFNA2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.64 ZBTB24
10 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.64 IFNA2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.64 ZBTB24
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.64 ZBTB24
13 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.64 ZBTB24
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.64 IFNA2 ZBTB24
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.64 IFNA2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.64 ZBTB24
17 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.64 ZBTB24
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 ZBTB24
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.64 ZBTB24

Drugs & Therapeutics for Granulomatous Hepatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Hepatitis

Genetic Tests for Granulomatous Hepatitis

Anatomical Context for Granulomatous Hepatitis

MalaCards organs/tissues related to Granulomatous Hepatitis:

41
Liver, Lung, Heart, Testes, T Cells, Smooth Muscle

Publications for Granulomatous Hepatitis

Articles related to Granulomatous Hepatitis:

(show top 50) (show all 219)
# Title Authors Year
1
Massive hemolysis complicating acute granulomatous hepatitis. ( 29675610 )
2018
2
Granulomatous hepatitis caused by Bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation: A case report. ( 29984182 )
2018
3
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. ( 28882937 )
2017
4
Acute granulomatous hepatitis in an immunosuppressed patient secondary to Q fever. ( 28549166 )
2017
5
Granulomatous hepatitis in a healthy adult after bacillus Calmette-GuAcrin injection into a plantar wart. ( 29159252 )
2017
6
Hepatobiliary and Pancreatic: Granulomatous hepatitis due to disseminated bacillus Calmette-GuAcrin disease. ( 28845587 )
2017
7
Allopurinol-Induced Granulomatous Hepatitis: A Case Report and Review of Literature. ( 29082266 )
2017
8
Granulomatous hepatitis: a rare primary manifestation of disseminated histoplasmosis in a renal transplant recipient. ( 28617878 )
2017
9
A case of fever of unknown origin due to granulomatous hepatitis due to tubercular etiology. ( 27728391 )
2016
10
A rare case of idiopathic granulomatous hepatitis presenting as tumoral lesion detected by 18F-FDG-PET/CT. ( 26626647 )
2016
11
Vemurafenib-induced granulomatous hepatitis. ( 27335285 )
2016
12
X-linked Inhibitor of Apoptosis Complicated by Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) and Granulomatous Hepatitis. ( 27492372 )
2016
13
Angiostrongylus vasorum Causing Severe Granulomatous Hepatitis with Concurrent Multiple Acquired PSS. ( 26355583 )
2015
14
Granulomatous hepatitis with hepatic mass lesions and a response to infliximab. ( 26134699 )
2015
15
A case of acute interstitial nephritis and granulomatous hepatitis induced by ingesting quinine. ( 28509275 )
2015
16
Histoplasmosis presenting as granulomatous hepatitis: case report and review of the literature. ( 25013413 )
2014
17
A rare case of fever of unknown origin. Idiopathic granulomatous hepatitis. ( 24825816 )
2014
18
D-penicillamine-induced granulomatous hepatitis in brown Norway rats. ( 24771069 )
2014
19
Co-occurrence of Idiopathic Granulomatous Hepatitis and Primary Biliary Cirrhosis. ( 25108519 )
2014
20
A 60-year-old man with fever, cholestasis and granulomatous hepatitis. ( 24525009 )
2014
21
Granulomatous hepatitis secondary to histoplasma infection after treatment with infliximab. ( 25379301 )
2013
22
Concurrent granulomatous hepatitis, pneumonitis and sepsis as a complication of intravesical BCG immunotherapy. ( 24114600 )
2013
23
Non-Tuberculous Mycobacterium: A Rare Cause of Granulomatous Hepatitis. ( 27785230 )
2013
24
Isolated granulomatous hepatitis-A histopathological surprise mimicking cholangiocarcinoma in ulcerative colitis. ( 23396747 )
2013
25
Granulomatous hepatitis as a rare complication of Bacillus Calmette-Gurin vaccination. ( 24413871 )
2013
26
Granulomatous hepatitis caused by Q fever: a differential diagnosis of fever of unknown origin. ( 23293205 )
2013
27
Albendazole-induced granulomatous hepatitis: a case report. ( 23889970 )
2013
28
Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient. ( 22269175 )
2012
29
Multiple organ failure and granulomatous hepatitis following intravesical bacillus Calmette-GuAcrin instillation. ( 23189546 )
2012
30
A young adult presenting with granulomatous hepatitis and nephrotic syndrome: A case report. ( 23095309 )
2012
31
Limited yield of diagnoses of intrahepatic infectious causes of canine granulomatous hepatitis from archival liver tissue. ( 22855374 )
2012
32
Granulomatous hepatitis after intravesical bacillus Calmette-GuAcrin treatment. ( 20854217 )
2011
33
Granulomatous hepatitis, choroiditis and aortoduodenal fistula complicating intravesical Bacillus Calmette-GuAcrin therapy: Case report. ( 21961922 )
2011
34
Granulomatous hepatitis from disseminated Mycobacterium bovis infection: shift of an intended local towards a detrimental systemic infection. ( 21922888 )
2011
35
Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report. ( 20594295 )
2010
36
Hypercalcemia worsened by the use of furosemide in a patient suffering from allopurinol-induced granulomatous hepatitis. ( 20361854 )
2010
37
Abnormal liver enzymes in a patient with Crohn's disease, psoriatic arthritis, and recurrent pancreatitis. Answer to the clinical challenges and images in GI question: image 5: Idiopathic granulomatous hepatitis. ( 20600067 )
2010
38
"Ohio River valley fever" presenting as isolated granulomatous hepatitis: a case report. ( 19434026 )
2009
39
Granulomatous hepatitis, perihepatic lymphadenopathies, and autoantibody positivity: an unusual association in a child with hepatitis C. ( 18509673 )
2009
40
Cyclophosphamide therapy in granulomatous hepatitis: cure or culprit? ( 19262358 )
2009
41
Peritoneal tuberculosis and granulomatous hepatitis secondary to treatment of bladder cancer with Bacillus Calmette-GuAcrin. ( 19368735 )
2009
42
Frequency and predictive factors of granulomatous hepatitis in patients with peritoneal tuberculosis. ( 19927783 )
2009
43
The use of infliximab in a patient with idiopathic granulomatous hepatitis. ( 21686858 )
2009
44
Granulomatous hepatitis following open heart surgery with cardiopulmonary bypass. ( 19320320 )
2008
45
Enhanced expression of transforming growth factor-beta 1 in inflammatory cells, alpha-smooth muscle actin in stellate cells, and collagen accumulation in experimental granulomatous hepatitis caused by Toxocara canis in mice. ( 18178169 )
2008
46
Multifocal granulomatous hepatitis caused by Actinobacillus pleuropneumoniae serotype 2 in slaughter pigs. ( 18617183 )
2008
47
Granulomatous hepatitis: tuberculosis or not? ( 18241177 )
2008
48
Granulomatous hepatitis associated with etanercept therapy. ( 18260163 )
2008
49
Sarcoidosis with granulomatous hepatitis and autoimmune endocrine involvement. ( 19082207 )
2008
50
Necrotizing granulomatous hepatitis in slaughtered broilers. ( 17626499 )
2007

Variations for Granulomatous Hepatitis

Expression for Granulomatous Hepatitis

Search GEO for disease gene expression data for Granulomatous Hepatitis.

Pathways for Granulomatous Hepatitis

Pathways related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 ACTA1 EZR
2 11.05 ACTA1 EZR
3 11 ACTA1 EZR
4 10.91 ACTA1 EZR
5 10.54 ACTA1 EZR
6 10.24 ACTA1 EZR

GO Terms for Granulomatous Hepatitis

Cellular components related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ACTA1 CRP EZR IFNA2
2 actin cytoskeleton GO:0015629 9.32 ACTA1 EZR
3 cell body GO:0044297 9.16 ACTA1 EZR
4 actin filament GO:0005884 8.96 ACTA1 EZR
5 filopodium GO:0030175 8.62 ACTA1 EZR

Biological processes related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.8 ACTA1 CRP EZR

Sources for Granulomatous Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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