MCID: GRN009
MIFTS: 34

Granulomatous Hepatitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Granulomatous Hepatitis

MalaCards integrated aliases for Granulomatous Hepatitis:

Name: Granulomatous Hepatitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2239
NCIt 50 C27015
SNOMED-CT 67 86514004
ICD10 32 K75.3
UMLS 70 C0235369

Summaries for Granulomatous Hepatitis

MalaCards based summary : Granulomatous Hepatitis is related to cat-scratch disease and sarcoidosis 1. An important gene associated with Granulomatous Hepatitis is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are T cell receptor signaling pathway and Allograft rejection. The drug Liver Extracts has been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for Granulomatous Hepatitis

Diseases related to Granulomatous Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 718)
# Related Disease Score Top Affiliating Genes
1 cat-scratch disease 30.5 CRP CD4 ACE
2 sarcoidosis 1 30.4 TNF CRP CD8A CD4 ACE
3 acute cholangitis 30.4 GPT CRP ALB
4 secondary syphilis 30.3 CRP CD8A CD4
5 vasculitis 30.3 TNF CTLA4 CRP
6 lymphadenitis 30.2 TNF CRP CD4
7 hepatitis a 30.2 TNF GPT CTLA4 CD4 ALB
8 interstitial nephritis 30.2 CRP ALB ACE
9 hyperuricemia 30.2 GPT CRP ALB
10 tuberculous peritonitis 30.2 CRP ALB
11 portal hypertension 30.0 TNF GPT CD4 ALB ACE
12 splenic infarction 30.0 GPT CRP ALB
13 giardiasis 30.0 CD8A CD4 ALB
14 drug-induced hepatitis 30.0 TNF GPT ALB
15 cholelithiasis 30.0 GPT CRP ALB
16 tularemia 30.0 TNF CD8A CD4
17 cholangitis 29.9 TNF GPT CTLA4 CRP ALB
18 typhoid fever 29.9 TNF GPT CRP ALB
19 scrub typhus 29.9 TNF GPT CRP
20 meningitis 29.9 TNF CRP ALB
21 aortitis 29.9 TNF CRP CD4
22 interstitial lung disease 29.9 TNF CRP ALB
23 myocarditis 29.9 TNF CTLA4 ACE
24 bartonellosis 29.9 CRP CD4 ACE
25 primary biliary cholangitis 29.9 GPT CTLA4 CD8A CD4 ALB
26 choroiditis 29.9 TNF CD4 ACE
27 proteasome-associated autoinflammatory syndrome 1 29.9 TNF CRP ALB
28 peritonitis 29.9 TNF CRP ALB
29 sclerosing cholangitis 29.8 TNF GPT CTLA4 ALB
30 schistosomiasis 29.8 TNF GPT CTLA4 ALB
31 hypercholesterolemia, familial, 1 29.7 GPT CRP ACE
32 non-alcoholic fatty liver disease 29.7 TNF GPT CRP ALB
33 erythema nodosum 29.7 TNF CTLA4 CRP
34 pfeiffer syndrome 29.7 CR2 CD8A CD4
35 viral hepatitis 29.7 TNF GPT CRP ALB
36 miliary tuberculosis 29.7 TNF CRP CD8A CD4 ALB
37 neutropenia 29.7 TNF GPT CRP ALB
38 leprosy 3 29.7 TNF CTLA4 CD8A CD4 ALB
39 liver cirrhosis 29.6 TNF GPT CRP CD8A ALB ACE
40 pancytopenia 29.6 CRP CD8A CD4 ACE
41 hypersensitivity vasculitis 29.6 TNF CRP ALB ACE
42 pericarditis 29.6 TNF CRP ALB ACE
43 urticaria 29.6 TNF CRP CD4 ACE
44 hyperthyroidism 29.6 GPT CTLA4 CRP ALB
45 autoimmune hepatitis 29.6 TNF GPT CTLA4 ALB
46 lung disease 29.6 TNF CRP CD8A ALB ACE
47 agammaglobulinemia 29.5 TNFRSF13B TNF CR2
48 nephrotic syndrome 29.5 TNF CRP ALB ACE
49 granulomatosis with polyangiitis 29.5 TNF CTLA4 CRP CD4
50 crohn's disease 29.5 TNF CTLA4 CRP CD4 ALB

Graphical network of the top 20 diseases related to Granulomatous Hepatitis:



Diseases related to Granulomatous Hepatitis

Symptoms & Phenotypes for Granulomatous Hepatitis

MGI Mouse Phenotypes related to Granulomatous Hepatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 ACE CCL21 CD4 CD8A CR2 CTLA4
2 immune system MP:0005387 9.32 ACE ALB CCL21 CD4 CD8A CR2

Drugs & Therapeutics for Granulomatous Hepatitis

Drugs for Granulomatous Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Lyon Granulomatous Hepatitis Study Recruiting NCT04459897

Search NIH Clinical Center for Granulomatous Hepatitis

Genetic Tests for Granulomatous Hepatitis

Anatomical Context for Granulomatous Hepatitis

MalaCards organs/tissues related to Granulomatous Hepatitis:

40
Liver, Bone Marrow, Bone, Spleen, Heart, Smooth Muscle, Kidney

Publications for Granulomatous Hepatitis

Articles related to Granulomatous Hepatitis:

(show top 50) (show all 624)
# Title Authors PMID Year
1
BCG infection (BCGitis) following intravesical instillation for bladder cancer and time interval between treatment and presentation: A systematic review. 61
33308969 2021
2
Primary Biliary Cirrhosis and Granulomatous Hepatitis After Immune Checkpoint Blockade in Patients With Metastatic Melanoma: Report of 2 Cases and Literature Discussion. 61
33323872 2021
3
Novel atypical Aeromonas salmonicida bath challenge model for juvenile ballan wrasse (Labrus bergylta, Ascanius). 61
33277726 2020
4
Clinical and histopathological changes in rainbow trout Oncorhynchus mykiss experimentally infected with fungus Bradymyces oncorhynchi. 61
32729017 2020
5
Toxocariasis Presenting with Hypereosinophilia and Lymphadenopathy: A Case Report. 61
33269576 2020
6
Nocardia seriolae: a serious threat to the largemouth bass Micropterus salmoides industry in Southwest China. 61
33150871 2020
7
Xpert MTB/RIF for diagnosis of tubercular liver abscess. A case series. 61
32920579 2020
8
A rare cause of granulomatous hepatitis: Tularemia. 61
31937491 2020
9
Q-fever associated granulomatous hepatitis. 61
32283284 2020
10
Drug and herbal/dietary supplements-induced liver injury: A tertiary care center experience. 61
32547688 2020
11
Cholestasis and disseminated histoplasmosis in a psoriatic patient on infliximab: case report and review of literature. 61
32384881 2020
12
A young girl with hypogammaglobulinemia and granulomatous hepatitis caused by a novel mutation in ZBTB24 gene: A case based analysis. 61
32061411 2020
13
Cutaneous vasculitis and granulomatous hepatitis as paradoxical adverse events of Infliximab. 61
32895360 2020
14
Granulomatous hepatitis masquerading as metastases on FDG PET/CT. 61
31641783 2020
15
Immune-related adverse reactions in the hepatobiliary system: second-generation check-point inhibitors highlight diverse histological changes. 61
31550390 2020
16
Rare case of a proximal descending thoracic aorta mycotic aneurysm following intravesical BCG injections for the treatment of bladder cancer. 61
31843771 2019
17
Extrapulmonary sarcoidosis primarily presenting as cholestatic liver disease. 61
31806633 2019
18
Checkpoint inhibitor-induced liver injury: A novel form of liver disease emerging in the era of cancer immunotherapy. 61
31358424 2019
19
Acute liver failure due to visceral leishmaniasis in Barcelona: a case report. 61
31640598 2019
20
Pyogranulomatous enteritis and mesenteric lymphadenitis in an adult llama caused by Rhodococcus equi carrying virulence-associated protein A gene. 61
31272304 2019
21
Amoxicillin-clavulanate-induced Granulomatous Hepatitis: Case Report and Review of the Literature. 61
31608221 2019
22
Kratom-Induced Cholestatic Liver Injury Mimicking Anti-Mitochondrial Antibody-Negative Primary Biliary Cholangitis: A Case Report and Review of Literature. 61
31523332 2019
23
Abatacept induced granulomatous hepatitis with a sarcoidosis- like reaction: a blinded trial in mice. 61
31064410 2019
24
Granulomatous hepatitis by Nocardia species: An unusual case. 61
30731130 2019
25
Hepatotoxicity induced by immune checkpoint inhibitors: a comprehensive review including current and alternative management strategies. 61
30677306 2019
26
Calodium hepaticum (Trichuroidea: Capillariidae) Infection In Akodon azarae: First Description of Histopathological Lesions In Sigmodontinae. 61
30807714 2019
27
Hepatic leptospiral infections in dogs without obvious renal involvement. 61
30499209 2019
28
Hepatic Sarcoidosis: Natural History and Management Implications. 61
31737633 2019
29
The Sudden Development of Multi-Organ Lesions in a Patient With Pulmonary Sarcoidosis: A Case Report. 61
30938179 2019
30
Characterization of Brucella canis infection in mice. 61
31220185 2019
31
Etanercept-induced granulomatous hepatitis as a rare cause of abnormal liver tests. 61
30888761 2019
32
Granulomatous Hepatitis with Miliary Mottling: A Rare Cause. 61
31321943 2018
33
Massive hemolysis complicating acute granulomatous hepatitis. 61
29675610 2018
34
Granulomatous hepatitis caused by Bacillus Calmette-Guerin (BCG) infection after BCG bladder instillation: A case report. 61
29984182 2018
35
Characterization of liver injury induced by cancer immunotherapy using immune checkpoint inhibitors. 61
29427729 2018
36
Correction: Granulomatous hepatitis in a healthy adult after bacillus Calmette-Guerin injection into a plantar wart. 61
30886883 2018
37
Hepatobiliary Manifestations and Complications in Inflammatory Bowel Disease: A Review. 61
29707074 2018
38
Spontaneous Resolution of Symptomatic Hepatic Sarcoidosis. 61
30155317 2018
39
Histoplasmosis hepatitis after orthotopic liver transplantation. 61
29250310 2017
40
Granulomatous hepatitis in a healthy adult after bacillus Calmette-Guérin injection into a plantar wart. 61
29159252 2017
41
Granulomatous hepatitis in a patient with Crohn's disease and cholestasis. 61
28882937 2017
42
Hepatobiliary and Pancreatic: Granulomatous hepatitis due to disseminated bacillus Calmette-Guérin disease. 61
28845587 2017
43
Acute granulomatous hepatitis in an immunosuppressed patient secondary to Q fever. 61
28549166 2017
44
Management of Hepatic Granulomatous Tuberculosis After BCG Therapy for Bladder Cancer. 61
28567336 2017
45
Allopurinol-Induced Granulomatous Hepatitis: A Case Report and Review of Literature. 61
29082266 2017
46
Granulomatous hepatitis: a rare primary manifestation of disseminated histoplasmosis in a renal transplant recipient. 61
28617878 2017
47
Hepatic manifestations of inflammatory bowel diseases. 61
27712010 2017
48
Vemurafenib-induced granulomatous hepatitis. 61
27335285 2017
49
Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice. 61
29091912 2017
50
X-linked Inhibitor of Apoptosis Complicated by Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) and Granulomatous Hepatitis. 61
27492372 2016

Variations for Granulomatous Hepatitis

Expression for Granulomatous Hepatitis

Search GEO for disease gene expression data for Granulomatous Hepatitis.

Pathways for Granulomatous Hepatitis

GO Terms for Granulomatous Hepatitis

Cellular components related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TNF GPT CRP CCL21 ALB ACTA1
2 external side of plasma membrane GO:0009897 9.02 TNF CTLA4 CD8A CD4 ACE

Biological processes related to Granulomatous Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.65 TNFRSF13B CTLA4 CR2 CD8A CD4
2 negative regulation of B cell proliferation GO:0030889 9.32 TNFRSF13B CTLA4
3 negative regulation of lipid storage GO:0010888 9.16 TNF CRP
4 positive regulation of protein kinase activity GO:0045860 9.13 TNF CD4 CCL21
5 immune response GO:0006955 9.1 TNF CTLA4 CR2 CD8A CD4 CCL21

Sources for Granulomatous Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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