MCID: GRN033
MIFTS: 30

Granulomatous Mastitis

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Granulomatous Mastitis

MalaCards integrated aliases for Granulomatous Mastitis:

Name: Granulomatous Mastitis 59 72
Idiopathic Granulomatous Mastitis 59

Classifications:



External Ids:

MESH via Orphanet 45 D058890
ICD10 via Orphanet 34 N61
UMLS via Orphanet 73 C0405469
Orphanet 59 ORPHA64722
UMLS 72 C0405469

Summaries for Granulomatous Mastitis

MalaCards based summary : Granulomatous Mastitis, also known as idiopathic granulomatous mastitis, is related to granulomatous lobular mastitis and mastitis. An important gene associated with Granulomatous Mastitis is IL33 (Interleukin 33), and among its related pathways/superpathways is Deubiquitination. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, neutrophil and pituitary.

Wikipedia : 75 Granulomatous mastitis can be divided into idiopathic granulomatous mastitis (also known as granular... more...

Related Diseases for Granulomatous Mastitis

Diseases related to Granulomatous Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 granulomatous lobular mastitis 11.9
2 mastitis 11.2
3 breast disease 10.8
4 breast cancer 10.8
5 breast abscess 10.5
6 inflammatory breast carcinoma 10.5
7 hyperprolactinemia 10.5
8 sarcoidosis 1 10.4
9 autoimmune disease 10.4
10 pituitary adenoma, prolactin-secreting 10.3
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
12 reactive arthritis 10.2
13 histoplasmosis 10.1
14 hidradenitis suppurativa 10.1
15 hidradenitis 10.1
16 pituitary adenoma 10.1
17 galactorrhea 9.9
18 leprosy 3 9.9
19 granulomatosis with polyangiitis 9.9
20 major affective disorder 8 9.9
21 major affective disorder 9 9.9
22 alpha-1-antitrypsin deficiency 9.9
23 angiosarcoma 9.9
24 exanthem 9.9
25 ductal carcinoma in situ 9.9
26 igg4-related disease 9.9
27 sparganosis 9.9
28 lepromatous leprosy 9.9
29 alveolar echinococcosis 9.9
30 typhoid fever 9.9
31 coccidioidomycosis 9.9
32 squamous cell papilloma 9.9
33 echinococcosis 9.9
34 nodular nonsuppurative panniculitis 9.9
35 panniculitis 9.9
36 lymphadenitis 9.9
37 breast fibroadenoma 9.9
38 intraductal papilloma 9.9
39 papilloma 9.9
40 tic disorder 9.9
41 pulmonary tuberculosis 9.9
42 periarthritis 9.9
43 bipolar disorder 9.9
44 mood disorder 9.9
45 bone inflammation disease 9.9
46 cellulitis 9.9
47 skin disease 9.9
48 craniopharyngioma 9.9
49 pustulosis of palm and sole 9.9
50 breast angiosarcoma 9.9

Graphical network of the top 20 diseases related to Granulomatous Mastitis:



Diseases related to Granulomatous Mastitis

Symptoms & Phenotypes for Granulomatous Mastitis

Drugs & Therapeutics for Granulomatous Mastitis

Drugs for Granulomatous Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Dermatologic Agents Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Hydrocortisone 17-butyrate 21-propionate Phase 4
7 Hydrocortisone hemisuccinate Phase 4
8 Hydrocortisone-17-butyrate Phase 4
9 Respiratory System Agents Phase 4
10 glucocorticoids Phase 4
11 Hormones Phase 4
12 Anti-Asthmatic Agents Phase 4
13 Hormone Antagonists Phase 4
14 Betamethasone-17,21-dipropionate Phase 4
15 Betamethasone Valerate Phase 4 2152-44-5
16 Betamethasone sodium phosphate Phase 4
17 Betamethasone benzoate Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19
Methotrexate Approved 1959-05-2, 59-05-2 126941
20
Prednisone Approved, Vet_approved 53-03-2 5865
21
Lidocaine Approved, Vet_approved 137-58-6 3676
22
Ceftriaxone Approved 73384-59-5 5479530 5361919
23
Triamcinolone Approved, Vet_approved 124-94-7 31307
24 Anti-Bacterial Agents
25 Antibiotics, Antitubercular
26 Contraceptives, Oral
27 Contraceptive Agents
28 Chlorhexidine gluconate
29 Immunosuppressive Agents
30 triamcinolone acetonide
31 Pharmaceutical Solutions
32 Triamcinolone hexacetonide
33 Triamcinolone diacetate
34 Anesthetics
35 Calamus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
2 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
3 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
4 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
5 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Recruiting NCT03724903 Corticosteroid therapy

Search NIH Clinical Center for Granulomatous Mastitis

Genetic Tests for Granulomatous Mastitis

Anatomical Context for Granulomatous Mastitis

MalaCards organs/tissues related to Granulomatous Mastitis:

41
Breast, Neutrophil, Pituitary, Liver, Skin, Lymph Node

Publications for Granulomatous Mastitis

Articles related to Granulomatous Mastitis:

(show top 50) (show all 445)
# Title Authors PMID Year
1
[Idiopathic granulomatous mastitis associated with erythema nodosum]. 38
31151772 2019
2
Re-evaluating if observation continues to be the best management of idiopathic granulomatous mastitis. 38
31400951 2019
3
Diagnosis and Treatment of 75 Patients with Idiopathic Lobular Granulomatous Mastitis. 38
29381437 2019
4
Granulomatous Mastitis and Factors Associated with Recurrence: An 11-Year Single-Centre Study of 113 Patients in Singapore. 38
31049604 2019
5
Comparison of Topical, Systemic, and Combined Therapy with Steroids on Idiopathic Granulomatous Mastitis: A Prospective Randomized Study. 38
31297582 2019
6
Idiopathic granulomatous mastitis: Looking for the most effective therapy with the least side effects according to the severity of the disease in 374 patients in Iran. 38
31087459 2019
7
[Value of shear wave elastrography image classification in the diagnosis of breast masses]. 38
31357843 2019
8
Idiopathic granulomatous mastitis: A systematic review of 3060 patients. 38
31273861 2019
9
Surgical treatment of granulomatous mastitis: Our experience in Bahrain. 38
31187555 2019
10
Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis. 38
31203215 2019
11
Imaging features of granulomatous mastitis in 36 patients with new sonographic signs. 38
31175613 2019
12
Tuberculosis of Male Breast: A Rare Benign Entity. 38
31355069 2019
13
Male granulomatous mastitis, a rarely encountered disorder. 38
30972881 2019
14
A Rare Case of Idiopathic Granulomatous Mastitis in a Nulliparous Woman with Hyperprolactinemia. 38
31328071 2019
15
Corynebacterium kroppenstedtii: a challenging culprit in breast abscesses and granulomatous mastitis. 38
30946032 2019
16
Breast ultrasound utilization in a safety net emergency department. 38
30377859 2019
17
A Proposal of a Clinically Based Classification for Idiopathic Granulomatous Mastitis 38
30912417 2019
18
A successful case of etanercept used for idiopathic granulomatous mastitis. 38
30790374 2019
19
Idiopathic Granulomatous Mastitis - a new approach in diagnostics and treatment. 38
30943750 2019
20
Ductal Lavage for Patients With Nonlactational Mastitis: A Single-Arm, Proof-of-Concept Trial. 38
30691827 2019
21
Cystic neutrophilic granulomatous mastitis: The Cleveland Clinic experience with diagnosis and management. 38
30449049 2019
22
Role of Bacteriological Agents in Idiopathic Granulomatous Mastitis: Real or Not? 38
30816358 2019
23
Human leukocyte antigens class I and II in patients with idiopathic granulomatous mastitis. 38
30739742 2019
24
Spectrum of Breast Diseases: Histopathological and Immunohistochemical Study from North India. 38
30956191 2019
25
Idiopathic granulomatous mastitis. 38
30758334 2019
26
Diagnostic techniques and multidisciplinary approach in idiopathic granulomatous mastitis: a revision of the literature. 38
30889150 2019
27
Are all Granulomatous Mastitis Cases Tuberculous?: A Study on the Role of Cytology in Evaluation of Granulomatous Mastitis. 38
30632120 2019
28
Granulomatous Mastitis: A Therapeutic and Diagnostic Challenge. 38
30800035 2018
29
Idiopathic granulomatous mastitis: A retrospective cohort study between 44 patients with different treatment modalities. 38
30479764 2018
30
Idiopathic granulomatous mastitis: a 10-year study from a multicentre clinical database. 38
30389215 2018
31
Cystic neutrophilic granulomatous mastitis: A clinicopathologic study of a distinct entity with supporting evidence of a role for Corynebacterium-targeted therapy. 38
30248572 2018
32
Use of Imaging for the Diagnosis of Idiopathic Granulomatous Mastitis: A Clinician's Perspective. 38
30369380 2018
33
Tuberculosis mastitis presenting as bilateral breast masses. 38
29514120 2018
34
Cytomorphological features of cystic neutrophilic granulomatous mastitis on ThinPrep. 38
30353674 2018
35
Cystic neutrophilic granulomatous mastitis with corynebacterium and staphylococcus mimicking breast carcinoma. 38
30455922 2018
36
Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. 38
29971624 2018
37
A case report of TB versus idiopathic granulomatous mastitis with erythema nodosum, reactive arthritis, cough, and headache. 38
30293476 2018
38
Novel selective medium for the isolation of corynebacterium kroppenstedtii from heavily colonised clinical specimens. 38
29593062 2018
39
Granulomatous mastitis: We need a useful classification system. 38
28864358 2018
40
Idiopathic lobular granulomatous mastitis: radiological management in two cases. 38
29793678 2018
41
Case Report: Ductal Carcinoma in Situ Within A Granulomatous Mastitis. 38
30123886 2018
42
Corynebacterium kroppenstedtii in granulomatous mastitis: Analysis of formalin-fixed, paraffin-embedded biopsy specimens by immunostaining using low-specificity bacterial antisera and real-time polymerase chain reaction. 38
29862601 2018
43
Can Fine Needle Aspiration Cytology be Used as a "Proxy Gold Standard" to Diagnose Tuberculous Mastitis? 38
30089945 2018
44
Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study? 38
28749045 2018
45
Scoring Idiopathic Granulomatous Mastitis: An Effective System for Predicting Recurrence? 38
29774320 2018
46
The microbiology and treatment of human mastitis. 38
29350290 2018
47
Idiopathic Granulomatous Mastitis: Manifestations at Multimodality Imaging and Pitfalls. 38
29528819 2018
48
Idiopathic granulomatous mastitis. A rare benign entitiy that can simulate breast cancer. 38
28733047 2018
49
[Multi-variated analysis of differential diagnosis in ultrasonography of idiopathic granulomatous mastitis and invasive ductal carcinoma]. 38
29575844 2018
50
Advantages of b-mode ultrasound combined with strain elastography in differentiation of idiopathic granulomatous mastitis from malignant breast lesions 38
29479939 2018

Variations for Granulomatous Mastitis

Expression for Granulomatous Mastitis

Search GEO for disease gene expression data for Granulomatous Mastitis.

Pathways for Granulomatous Mastitis

Pathways related to Granulomatous Mastitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 NOD2 IL33

GO Terms for Granulomatous Mastitis

Biological processes related to Granulomatous Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 8.96 NOD2 IL33
2 positive regulation of type 2 immune response GO:0002830 8.62 NOD2 IL33

Sources for Granulomatous Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....