MCID: GRN033
MIFTS: 32

Granulomatous Mastitis

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Granulomatous Mastitis

MalaCards integrated aliases for Granulomatous Mastitis:

Name: Granulomatous Mastitis 58 71
Idiopathic Granulomatous Mastitis 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

MESH via Orphanet 45 D058890
ICD10 via Orphanet 33 N61
UMLS via Orphanet 72 C0405469
Orphanet 58 ORPHA64722
UMLS 71 C0405469

Summaries for Granulomatous Mastitis

MalaCards based summary : Granulomatous Mastitis, also known as idiopathic granulomatous mastitis, is related to mastitis and granulomatous lobular mastitis. An important gene associated with Granulomatous Mastitis is IL33 (Interleukin 33), and among its related pathways/superpathways are Deubiquitination and Toll-Like receptor Signaling Pathways. The drugs Betamethasone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, neutrophil and pituitary.

Wikipedia : 74 Granulomatous mastitis can be divided into idiopathic granulomatous mastitis (also known as granular... more...

Related Diseases for Granulomatous Mastitis

Diseases related to Granulomatous Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 mastitis 31.3 NOD2 IL33
2 granulomatous lobular mastitis 11.4
3 breast disease 10.8
4 erythema nodosum 10.7
5 breast abscess 10.5
6 inflammatory breast carcinoma 10.5
7 sarcoidosis 1 10.4
8 hyperprolactinemia 10.4
9 autoimmune disease 10.4
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
11 breast cancer 10.3
12 pituitary adenoma, prolactin-secreting 10.3
13 disease by infectious agent 10.1
14 hidradenitis suppurativa 10.1
15 hidradenitis 10.1
16 reactive arthritis 10.1
17 granulomatosis with polyangiitis 10.1
18 exanthem 10.1
19 histoplasmosis 10.1
20 skin disease 10.1
21 pituitary adenoma 10.1
22 adenoma 10.1
23 arthritis 10.1
24 bladder cancer 9.9
25 galactorrhea 9.9
26 leprosy 3 9.9
27 myxedema 9.9
28 ocular motor apraxia 9.9
29 sjogren syndrome 9.9
30 major affective disorder 8 9.9
31 major affective disorder 9 9.9
32 alpha-1-antitrypsin deficiency 9.9
33 angiosarcoma 9.9
34 ductal carcinoma in situ 9.9
35 igg4-related disease 9.9
36 sparganosis 9.9
37 lepromatous leprosy 9.9
38 alveolar echinococcosis 9.9
39 typhoid fever 9.9
40 coccidioidomycosis 9.9
41 squamous cell papilloma 9.9
42 hypothyroidism 9.9
43 echinococcosis 9.9
44 nodular nonsuppurative panniculitis 9.9
45 panniculitis 9.9
46 lymphadenitis 9.9
47 breast fibroadenoma 9.9
48 intraductal papilloma 9.9
49 papilloma 9.9
50 tic disorder 9.9

Graphical network of the top 20 diseases related to Granulomatous Mastitis:



Diseases related to Granulomatous Mastitis

Symptoms & Phenotypes for Granulomatous Mastitis

Drugs & Therapeutics for Granulomatous Mastitis

Drugs for Granulomatous Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4 Respiratory System Agents Phase 4
5 Anti-Asthmatic Agents Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Hormones Phase 4
8 Hormone Antagonists Phase 4
9 glucocorticoids Phase 4
10 Betamethasone sodium phosphate Phase 4
11 Dermatologic Agents Phase 4
12 Betamethasone benzoate Phase 4
13 Betamethasone-17,21-dipropionate Phase 4
14 Hydrocortisone hemisuccinate Phase 4
15 Hydrocortisone-17-butyrate Phase 4
16 Betamethasone Valerate Phase 4 2152-44-5
17 Hydrocortisone 17-butyrate 21-propionate Phase 4
18 Prednisolone acetate Approved, Vet_approved 52-21-1
19
Prednisolone Approved, Vet_approved 50-24-8 5755
20
Methylprednisolone hemisuccinate Approved 2921-57-5
21
Methylprednisolone Approved, Vet_approved 83-43-2 6741
22
Prednisolone phosphate Approved, Vet_approved 302-25-0
23
Methotrexate Approved 1959-05-2, 59-05-2 126941
24
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
25
Ceftriaxone Approved 73384-59-5 5479530 5361919
26
Lidocaine Approved, Vet_approved 137-58-6 3676
27
Triamcinolone Approved, Vet_approved 124-94-7 31307
28
Prednisone Approved, Vet_approved 53-03-2 5865
29
Prednisolone hemisuccinate Experimental 2920-86-7
30 Antibiotics, Antitubercular
31 Anti-Bacterial Agents
32 Methylprednisolone Acetate
33 Contraceptive Agents
34 Contraceptives, Oral
35 Chlorhexidine gluconate
36 Immunosuppressive Agents
37 Interferon alpha-2
38 Interferon-alpha
39 Interleukin-12
40 Anesthetics
41 Pharmaceutical Solutions
42 Triamcinolone hexacetonide
43 triamcinolone acetonide
44 Triamcinolone diacetate
45 Calamus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Unknown status NCT02959580 Phase 4 Hydrocortisone Butyrate
2 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
3 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
4 Comparison of the Efficiency of Systemic Therapy and Intralesional Steroid Administration in the Treatment of Idiopathic Granulomatous Mastitis Completed NCT04596046
5 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
6 Evaluation of Immune Cells in Patients With Granulomatous Mastitis Completed NCT04543149
7 Evaluation of Serum Cytokine Values in Patients With Granulomatous Mastitis Completed NCT04540237
8 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Recruiting NCT03724903 Corticosteroid therapy
9 Traditional and Complementary Medicine: a Cure for Idiopathic Granulomatous Mastitis? Active, not recruiting NCT04096300
10 Idiopathic Granulomatous Mastitis Not yet recruiting NCT04424615

Search NIH Clinical Center for Granulomatous Mastitis

Genetic Tests for Granulomatous Mastitis

Anatomical Context for Granulomatous Mastitis

MalaCards organs/tissues related to Granulomatous Mastitis:

40
Breast, Neutrophil, Pituitary, B Cells

Publications for Granulomatous Mastitis

Articles related to Granulomatous Mastitis:

(show top 50) (show all 548)
# Title Authors PMID Year
1
The Role of Shear Wave Elastography in Differentiating Idiopathic Granulomatous Mastitis From Breast Cancer. 61
32217054 2021
2
Shear Wave Elastography and Shear Wave Velocity Value for Idiopathic Granulomatous Mastitis. 61
32773331 2021
3
Cystic neutrophilic granulomatous mastitis: Corynebacterium species-associated infection with distinct histology. 61
32653659 2021
4
The Effect of Soluble TREM-1 in Idiopathic Granulomatous Mastitis. 61
33522329 2021
5
Corticosteroids in idiopathic granulomatous mastitis: a systematic review and meta-analysis. 61
33590327 2021
6
Idiopathic Granulomatous Mastitis and Erythema nodosum - A Unifying Pathophysiology? 61
32935853 2021
7
A rheumatologic approach to granulomatous mastitis: A case series and review of the literature. 61
33523600 2021
8
Primary breast tuberculosis: imaging findings of a rare disease. 61
33587199 2021
9
Magnetic resonance imaging and contrast-enhanced ultrasound findings of a recurrent primary breast angiosarcoma: A case report. 61
33592915 2021
10
Granulomatosis with polyangiitis: a life-threatening cause of granulomatous mastitis. 61
32614984 2021
11
Unilateral granulomatous mastitis in a pregnant woman as a first manifestation of sarcoidosis. 61
33412962 2021
12
Breast sarcoidosis: Clinical features, imaging, and histological findings. 61
33034055 2021
13
Clinical and imaging features of idiopathic granulomatous mastitis - The diagnostic challenges and a brief review. 61
32717540 2021
14
What are the new findings with regard to the mysterious disease idiopathic granulomatous mastitis? 61
33511459 2021
15
Adalimumab in a patient with refractory idiopathic granulomatous mastitis: A case report. 61
33142352 2021
16
Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis. 61
33489755 2021
17
Challenges in management of idiopathic granulomatous mastitis during the pandemic of COVID-19. 61
33073462 2021
18
Pregnancy-associated granulomatous mastitis of accessory breast: A novel clinical presentation. 61
33381878 2020
19
Does ARFI elastography complement B-mode ultrasonography in the radiological diagnosis of idiopathic granulomatous mastitis and invasive ductal carcinoma? 61
33377394 2020
20
False-positive PET/CT finding in the idiopathic granulomatous mastitis: A case report. 61
33155735 2020
21
Cystic neutrophilic granulomatous mastitis: Archetypal case associated with Corynebacterium kroppenstedtii. 61
33216419 2020
22
Comment on: “Treatment of idiopathic granulomatous mastitis and factors related with disease recurrence” 61
32512677 2020
23
Comment on ‘Treatment of idiopathic granulomatous mastitis and factors related with disease recurrence’ 61
32892544 2020
24
Late-onset native valve endocarditis caused by Corynebacterium kroppenstedtii. 61
32947053 2020
25
[A Case Report of Triple Negative Breast Cancer Diagnosed as Granulomatous Mastitis]. 61
33468851 2020
26
Patients with idiopathic granulomatous mastitis accompanied by erythema nodosum. 61
33305438 2020
27
The Clinical Utility of Autoantibodies in Patients with Idiopathic Granulomatous Mastitis. 61
33327830 2020
28
Circulating miR-155, let-7c, miR-21, and PTEN levels in differential diagnosis and prognosis of idiopathic granulomatous mastitis and breast cancer. 61
32941675 2020
29
Postoperative Yanghe decoction regimen improves outcomes for idiopathic granulomatous mastitis: A retrospective cohort study. 61
33157994 2020
30
Effectiveness of Methotrexate in Idiopathic Granulomatous Mastitis Treatment. 61
32635989 2020
31
Red flags for the differential diagnosis of granulomatous mastitis: a case report. 61
33168069 2020
32
Cystic neutrophilic granulomatous mastitis - a review of 12 consecutive cases. 61
32557756 2020
33
Granulomatous Mastitis: Comparison of Novel Treatment of Steroid Injection and Current Management. 61
32497924 2020
34
Male granulomatous mastitis with hidradenitis suppurativa, a rarely encountered disorder. 61
32515519 2020
35
Multicentre, randomised, open-label, non-inferiority trial comparing the effectiveness and safety of ductal lavage versus oral corticosteroids for idiopathic granulomatous mastitis: a study protocol. 61
33039992 2020
36
Invited Discussion on: Management of Granulomatous Mastitis Following Aesthetic Breast Surgery. 61
33051720 2020
37
The Role of Regulatory T and B Cells in the Etiopathogenesis of Idiopathic Granulomatous Mastitis. 61
33034215 2020
38
Management of Granulomatous Mastitis Following Aesthetic Breast Surgery. 61
33033878 2020
39
Granulomatous mastitis, watch and wait is a good option. 61
33078264 2020
40
Is There any Relationship Between Granulomatous Mastitis and Seasons? An Analysis of Seasonal Frequency, Clinical, and Radiologic Findings. 61
33062962 2020
41
Bacteria Associated with Granulomatous Lobular Mastitis and the Potential for Personalized Therapy. 61
33059500 2020
42
White Blood Count Can Be a Practical Guide for the Differential Diagnosis of Breast Abscess and Idiopathic Granulomatous Mastitis. 61
33083171 2020
43
Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study. 61
32562354 2020
44
Granulomatous Mastitis: What Radiologists Should Know With Imaging Examples of Biopsy Proven Cases. 61
32956245 2020
45
Comparison of Conservative versus Surgical Treatment Protocols in Treating Idiopathic Granulomatous Mastitis: A Meta-Analysis. 61
32982653 2020
46
Bilateral idiopathic granulomatous mastitis. 61
32868320 2020
47
Comment on Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis. 61
32856839 2020
48
Cystic neutrophilic granulomatous mastitis: an update. 61
32094275 2020
49
Treatment of idiopathic granulomatous mastitis and factors related with disease recurrence 61
32394683 2020
50
The Predictive Value of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio in Patients with Recurrent Idiopathic Granulomatous Mastitis. 61
32656525 2020

Variations for Granulomatous Mastitis

Expression for Granulomatous Mastitis

Search GEO for disease gene expression data for Granulomatous Mastitis.

Pathways for Granulomatous Mastitis

GO Terms for Granulomatous Mastitis

Biological processes related to Granulomatous Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 9.32 NOD2 IL33
2 positive regulation of tumor necrosis factor production GO:0032760 9.26 NOD2 IL33
3 negative regulation of interferon-gamma production GO:0032689 9.16 NOD2 IL33
4 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 8.96 NOD2 IL33
5 positive regulation of type 2 immune response GO:0002830 8.62 NOD2 IL33

Sources for Granulomatous Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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