MCID: GRN033
MIFTS: 30

Granulomatous Mastitis

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Granulomatous Mastitis

MalaCards integrated aliases for Granulomatous Mastitis:

Name: Granulomatous Mastitis 58 71
Idiopathic Granulomatous Mastitis 58

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

MESH via Orphanet 44 D058890
ICD10 via Orphanet 33 N61
UMLS via Orphanet 72 C0405469
Orphanet 58 ORPHA64722
UMLS 71 C0405469

Summaries for Granulomatous Mastitis

MalaCards based summary : Granulomatous Mastitis, also known as idiopathic granulomatous mastitis, is related to mastitis and granulomatous lobular mastitis. An important gene associated with Granulomatous Mastitis is IL33 (Interleukin 33), and among its related pathways/superpathways are Deubiquitination and Toll-Like receptor Signaling Pathways. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, neutrophil and skin.

Wikipedia : 74 Granulomatous mastitis can be divided into idiopathic granulomatous mastitis (also known as granular... more...

Related Diseases for Granulomatous Mastitis

Diseases related to Granulomatous Mastitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 mastitis 31.0 NOD2 IL33
2 granulomatous lobular mastitis 11.9
3 breast disease 10.9
4 breast cancer 10.8
5 breast abscess 10.5
6 inflammatory breast carcinoma 10.5
7 sarcoidosis 1 10.5
8 hyperprolactinemia 10.5
9 autoimmune disease 10.4
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
11 pituitary adenoma, prolactin-secreting 10.3
12 hidradenitis suppurativa 10.2
13 hidradenitis 10.2
14 reactive arthritis 10.2
15 exanthem 10.1
16 histoplasmosis 10.1
17 pituitary adenoma 10.1
18 bladder cancer 9.9
19 galactorrhea 9.9
20 leprosy 3 9.9
21 sjogren syndrome 9.9
22 granulomatosis with polyangiitis 9.9
23 major affective disorder 8 9.9
24 major affective disorder 9 9.9
25 alpha-1-antitrypsin deficiency 9.9
26 angiosarcoma 9.9
27 ductal carcinoma in situ 9.9
28 igg4-related disease 9.9
29 sparganosis 9.9
30 lepromatous leprosy 9.9
31 alveolar echinococcosis 9.9
32 typhoid fever 9.9
33 coccidioidomycosis 9.9
34 squamous cell papilloma 9.9
35 echinococcosis 9.9
36 nodular nonsuppurative panniculitis 9.9
37 panniculitis 9.9
38 lymphadenitis 9.9
39 breast fibroadenoma 9.9
40 intraductal papilloma 9.9
41 papilloma 9.9
42 tic disorder 9.9
43 pulmonary tuberculosis 9.9
44 periarthritis 9.9
45 bipolar disorder 9.9
46 mood disorder 9.9
47 bone inflammation disease 9.9
48 cellulitis 9.9
49 skin disease 9.9
50 craniopharyngioma 9.9

Graphical network of the top 20 diseases related to Granulomatous Mastitis:



Diseases related to Granulomatous Mastitis

Symptoms & Phenotypes for Granulomatous Mastitis

Drugs & Therapeutics for Granulomatous Mastitis

Drugs for Granulomatous Mastitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
4 Respiratory System Agents Phase 4
5 Hormones Phase 4
6 glucocorticoids Phase 4
7 Hormone Antagonists Phase 4
8 Hydrocortisone 17-butyrate 21-propionate Phase 4
9 Anti-Asthmatic Agents Phase 4
10 Hydrocortisone-17-butyrate Phase 4
11 Dermatologic Agents Phase 4
12 Hydrocortisone hemisuccinate Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Betamethasone sodium phosphate Phase 4
15 Betamethasone Valerate Phase 4 2152-44-5
16 Betamethasone-17,21-dipropionate Phase 4
17 Betamethasone benzoate Phase 4
18
Methotrexate Approved 59-05-2, 1959-05-2 126941
19
Chlorhexidine Approved, Vet_approved 55-56-1 9552079 2713
20
Lidocaine Approved, Vet_approved 137-58-6 3676
21
Prednisone Approved, Vet_approved 53-03-2 5865
22
Ceftriaxone Approved 73384-59-5 5361919 5479530
23
Triamcinolone Approved, Vet_approved 124-94-7 31307
24 Anti-Bacterial Agents
25 Antibiotics, Antitubercular
26 Contraceptive Agents
27 Contraceptives, Oral
28 Chlorhexidine gluconate
29 Immunosuppressive Agents
30 Pharmaceutical Solutions
31 Anesthetics
32 Triamcinolone diacetate
33 Triamcinolone hexacetonide
34 triamcinolone acetonide
35 Calamus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Study on the Effectiveness of Local Injection Combined With Topical Steroids vs. Topical Steroids Mono-therapy in the Treatment of Idiopathic Granulomatous Mastitis Recruiting NCT03766997 Phase 4 Compound Betamethasone Injection;Hydrocortisone Butyrate 0.1% Cream
2 Evaluation of Topical Steroids and Surgical Treatment for Idiopathic Granulomatous Mastitis Recruiting NCT02959580 Phase 4 Hydrocortisone Butyrate
3 Ductal Lavage in Non-lactating Female Women With Mastitis: A Single Arm, Observational Study Completed NCT02794688
4 Granulomatous Mastitis Current Approach and Treatment (Multicentric Study) Granulomatous Mastitis Working Group Completed NCT02667132
5 Ductal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis: a Multicenter, Randomized, Open-labelled, Non-inferior Trial. Recruiting NCT03724903 Corticosteroid therapy
6 Traditional and Complementary Medicine: a Cure for Idiopathic Granulomatous Mastitis? Active, not recruiting NCT04096300
7 Idiopathic Granulomatous Mastitis Not yet recruiting NCT04424615

Search NIH Clinical Center for Granulomatous Mastitis

Genetic Tests for Granulomatous Mastitis

Anatomical Context for Granulomatous Mastitis

MalaCards organs/tissues related to Granulomatous Mastitis:

40
Breast, Neutrophil, Skin, Lymph Node, Pituitary, Liver

Publications for Granulomatous Mastitis

Articles related to Granulomatous Mastitis:

(show top 50) (show all 495)
# Title Authors PMID Year
1
Methotrexate in the Treatment of Idiopathic Granulomatous Mastitis. 61
31203215 2020
2
Male granulomatous mastitis with hidradenitis suppurativa, a rarely encountered disorder. 61
32515519 2020
3
Cystic neutrophilic granulomatous mastitis - a review of 12 consecutive cases from a Canadian center. 61
32557756 2020
4
Comment on Treatment of Idiopathic Granulomatous Mastitis and factors related with disease recurrence. 61
32512677 2020
5
Efficacy and safety of oncoplastic surgery plus drug therapy for chronic tuberculous granulomatous mastitis. 61
32553002 2020
6
Granulomatous Mastitis: Comparison of Novel Treatment of Steroid Injection and Current Management. 61
32497924 2020
7
Idiopathic granulomatous mastitis with erythema nodosum: Is it a variant of clinical presentation indicating treatment resistance? A retrospective cohort study. 61
32562354 2020
8
Comment on Idiopathic Granulomatous Mastitis with Skin Rupture: A Retrospective Cohort Study of 200 Patients Who Underwent Surgical and Nonsurgical Treatment. 61
32558610 2020
9
Response to Letter to Editor RE: Idiopathic Granulomatous Mastitis with Skin Rupture: A Retrospective Cohort Study of 200 Patients Who Underwent Surgical and Nonsurgical Treatment. 61
32567414 2020
10
Cystic Neutrophilic Granulomatous Mastitis: A Clinicopathological Study With 16s rRNA Sequencing for the Detection of Corynebacteria in Formalin-Fixed Paraffin-Embedded Tissue. 61
31870201 2020
11
"Re-evaluating if observation continues to be the best management of idiopathic granulomatous mastitis". 61
31889546 2020
12
TREATMENT OF IDIOPATHIC GRANULOMATOUS MASTITIS AND FACTORS RELATED WITH DISEASE RECURRENCE. 61
32394683 2020
13
Community-acquired granulomatous mastitis superinfected with Mycobacterium bolletii. 61
31806269 2020
14
Idiopathic granulomatous mastitis in a male breast following intravesical Bacille Calmette-Guerin treatment. 61
31591080 2020
15
The clinical value of interleukins-8, -10, and -17 in idiopathic granulomatous mastitis. 61
31916110 2020
16
Primary breast tuberculosis in a man: a case report. 61
32319945 2020
17
Cytomorphological Spectrum of Granulomatous Mastitis: A Study of 33 Cases. 61
32285037 2020
18
A systematic surgical approach for the treatment of idiopathic granulomatous mastitis: a case series. 61
32420250 2020
19
A very rare cause of male breast lump: Idiopathic granulomatous mastitis. 61
31486183 2020
20
Idiopathic granulomatous mastitis: Management and predictors of recurrence in 474 patients. 61
32249491 2020
21
Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis. 61
32334460 2020
22
"Thick Section" Gram Stain Yields Improved Detection of Organisms in Tissue Sections of Cystic Neutrophilic Granulomatous Mastitis. 61
31830244 2020
23
Granulomatous mastitis due to coinfection with Histoplasma sp. and Paracoccidioides sp.: A case report. 61
31993319 2020
24
The Role of Shear Wave Elastography in Differentiating Idiopathic Granulomatous Mastitis From Breast Cancer. 61
32217054 2020
25
Idiopathic Granulomatous Mastitis: Etiopathogenetic Considerations on a Rare Benign Inflammatory Breast Disease. 61
32200680 2020
26
Imaging features of granulomatous mastitis in 36 patients with new sonographic signs. 61
31175613 2020
27
Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players. 61
32235676 2020
28
Negative pressure wound therapy of Corynebacterium jeikeium associated granulomatous mastitis. 61
31512310 2020
29
Idiopathic granulomatous mastitis: a diagnostic dilemma. 61
32097077 2020
30
Idiopathic granulomatous mastitis responding to oral prednisone. 61
31686425 2020
31
Differentiation between idiopathic granulomatous mastitis and invasive breast carcinoma, both presenting with non-mass enhancement without rim-enhanced masses: The value of whole-lesion histogram and texture analysis using apparent diffusion coefficient. 61
31864142 2020
32
Cystic neutrophilic granulomatous mastitis: an update. 61
32094275 2020
33
New Findings on Autoimmune Etiology of Idiopathic Granulomatous Mastitis: Serum IL-17, IL-22 and IL-23 Levels of Patients. 61
32046543 2020
34
Idiopathic Granulomatous Mastitis-A Mystery Yet to be Unraveled: A Case Series and Review of Literature. 61
32195062 2020
35
Methotrexate-based regimen as initial treatment of patients with idiopathic granulomatous mastitis. 61
31495030 2020
36
The evaluation of the efficacy of local steroid administration in idiopathic granulomatous mastitis: The preliminary results. 61
31495032 2020
37
Idiopathic granulomatous mastitis in the male population: A clinical analysis of 13 reported cases. 61
32034843 2020
38
Severe idiopathic granulomatous mastitis treated with systemic medication; A case report. 61
31937165 2020
39
The Predictive Value of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratio in Patients with Recurrent Idiopathic Granulomatous Mastitis. 61
31912016 2020
40
The Role of Establishing a Multidisciplinary Team for Idiopathic Granulomatous Mastitis in Improving Patient Outcomes and Spreading Awareness about Recent Disease Trends. 61
32411481 2020
41
Novel Paradigm for Treating Idiopathic Granulomatous Mastitis. 61
31960715 2020
42
Clinical Characteristics and Medical Management of Idiopathic Granulomatous Mastitis. 61
31968055 2020
43
Chronic granulomatous mastitis with axillary lymphadenopathy in a nulliparous woman. 61
31929493 2019
44
Re-evaluating if observation continues to be the best management of idiopathic granulomatous mastitis. 61
31400951 2019
45
Breast tuberculosis: A case report of primary type mammary tuberculosis. 61
31893055 2019
46
Idiopathic Granulomatous Mastitis with Skin Rupture: A Retrospective Cohort Study of 200 Patients Who Underwent Surgical and Nonsurgical Treatment. 61
31818161 2019
47
Magnetic resonance imaging findings of idiopathic granulomatous mastitis: can it be an indirect sign of treatment success or fail? 61
31842782 2019
48
Mycobacterium mucogenicum skin and soft tissue infection of the breast mimicking idiopathic granulomatous mastitis. 61
31818890 2019
49
Comparison of Topical, Systemic, and Combined Therapy with Steroids on Idiopathic Granulomatous Mastitis: A Prospective Randomized Study. 61
31297582 2019
50
Idiopathic granulomatous mastitis: A systematic review of 3060 patients. 61
31273861 2019

Variations for Granulomatous Mastitis

Expression for Granulomatous Mastitis

Search GEO for disease gene expression data for Granulomatous Mastitis.

Pathways for Granulomatous Mastitis

GO Terms for Granulomatous Mastitis

Biological processes related to Granulomatous Mastitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of interleukin-6 production GO:0032755 8.96 NOD2 IL33
2 positive regulation of type 2 immune response GO:0002830 8.62 NOD2 IL33

Sources for Granulomatous Mastitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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