MCID: GRN036
MIFTS: 26

Granulomatous Myositis

Categories: Muscle diseases

Aliases & Classifications for Granulomatous Myositis

MalaCards integrated aliases for Granulomatous Myositis:

Name: Granulomatous Myositis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:3428
NCIt 50 C27575
UMLS 73 C1334150

Summaries for Granulomatous Myositis

MalaCards based summary : Granulomatous Myositis is related to myositis and asphyxia neonatorum. An important gene associated with Granulomatous Myositis is NAIP (NLR Family Apoptosis Inhibitory Protein), and among its related pathways/superpathways is TNFs bind their physiological receptors. Affiliated tissues include tongue and t cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Granulomatous Myositis

Diseases related to Granulomatous Myositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 myositis 31.0 NCAM1 PIK3C2A TTN
2 asphyxia neonatorum 10.6 PIK3C2A TTN
3 spinal muscular atrophy, type ii 10.6 NAIP NCAM1
4 pleomorphic adenoma carcinoma 10.6 LYZ PTHLH
5 angiomyoma 10.5 NCAM1 PTHLH
6 virus associated hemophagocytic syndrome 10.5 CD68 PIK3C2A
7 fiedler's myocarditis 10.5 CD68 PIK3C2A
8 central nervous system sarcoma 10.4 CD68 LYZ
9 malignant giant cell tumor of soft parts 10.4 CD68 LYZ
10 melanotic neurilemmoma 10.4 CD68 LYZ
11 adult xanthogranuloma 10.4 CD68 LYZ
12 periodic fever, familial, autosomal dominant 10.4 LYZ TNFRSF1B
13 acute salpingitis 10.4 LYZ TNFRSF1B
14 gallbladder small cell carcinoma 10.4 NCAM1 SMUG1
15 laryngeal tuberculosis 10.3 LYZ SMUG1
16 plexopathy 10.3 PIK3C2A SMUG1
17 rectum squamous cell carcinoma 10.3 SMUG1 TNFRSF1B
18 parasitic ichthyosporea infectious disease 10.3 CD68 NCAM1
19 rhinosporidiosis 10.3 CD68 NCAM1
20 endometrial small cell carcinoma 10.3 NCAM1 SMUG1
21 hemangioma of intra-abdominal structure 10.3 CD68 PTHLH
22 mediastinal cancer 10.3 NCAM1 SMUG1
23 chondromalacia 10.3 SMUG1 TNFRSF1B
24 lymphangiosarcoma 10.3 LYZ SMUG1
25 congenital epulis 10.3 CD68 LYZ
26 ulcerative stomatitis 10.2 CD68 LYZ
27 pulmonary artery leiomyosarcoma 10.2 CD68 SMUG1
28 legionellosis 10.2 NAIP PIK3C2A
29 brain sarcoma 10.2 CD68 SMUG1
30 lactocele 10.2 CD68 SMUG1
31 malignant skin fibrous histiocytoma 10.2 NCAM1 SMUG1
32 scrotal carcinoma 10.2 CD68 SMUG1
33 malignant dermis tumor 10.1 NCAM1 SMUG1
34 in situ pulmonary adenocarcinoma 10.1 LYZ SMUG1
35 tolosa-hunt syndrome 10.1 PRTN3 SMUG1
36 orbital plasma cell granuloma 10.1 NCAM1 PIK3C2A TNFRSF1B
37 granulomatous gastritis 10.1 CD68 PRTN3
38 pulmonary hemosiderosis 10.1 LYZ PRTN3
39 eumycotic mycetoma 10.0 CD68 SMUG1
40 liver sarcoma 10.0 CD68 LYZ PTHLH
41 pericardial tuberculosis 10.0 PRTN3 SMUG1
42 aleukemic leukemia cutis 10.0 CD68 LYZ NCAM1
43 multiple cranial nerve palsy 9.9 NCAM1 PRTN3
44 cogan syndrome 9.9 SMUG1 TNFRSF1B
45 endocardium disease 9.9 PRTN3 SMUG1
46 hypersensitivity reaction type iv disease 9.9 LYZ SMUG1 TNFRSF1B
47 lymphatic system cancer 9.9 LYZ TNFRSF8
48 pericoronitis 9.9 CD68 NCAM1 TNFRSF1B
49 rhinoscleroma 9.9 CD68 NCAM1 TNFRSF1B
50 hodgkin's lymphoma, lymphocytic depletion 9.9 CD68 TNFRSF8

Graphical network of the top 20 diseases related to Granulomatous Myositis:



Diseases related to Granulomatous Myositis

Symptoms & Phenotypes for Granulomatous Myositis

MGI Mouse Phenotypes related to Granulomatous Myositis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.76 LYZ NCAM1 PIK3C2A PRTN3 PTHLH SMUG1
2 hematopoietic system MP:0005397 9.5 CD68 LYZ PIK3C2A PRTN3 PTHLH TNFRSF1B
3 immune system MP:0005387 9.23 TNFRSF1B TNFRSF8 TTN CD68 LYZ PIK3C2A

Drugs & Therapeutics for Granulomatous Myositis

Search Clinical Trials , NIH Clinical Center for Granulomatous Myositis

Genetic Tests for Granulomatous Myositis

Anatomical Context for Granulomatous Myositis

MalaCards organs/tissues related to Granulomatous Myositis:

41
Tongue, T Cells

Publications for Granulomatous Myositis

Articles related to Granulomatous Myositis:

(show all 29)
# Title Authors Year
1
A Rare Case of Sarcoidosis Presenting as Diffuse Contracturing Granulomatous Myositis on Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29643679 )
2018
2
High prevalence of chigger mite infection in a forest-specialist frog with evidence of parasite-related granulomatous myositis. ( 29502295 )
2018
3
Non-granulomatous myositis in a patient with ulcerative colitis who showed symptoms resembling gastrocnemius myalgia syndrome. ( 28132973 )
2017
4
Hypercalcemia revealing diffuse granulomatous myositis. ( 28396910 )
2017
5
Sporadic inclusion body myositis misdiagnosed as idiopathic granulomatous myositis. ( 27692540 )
2016
6
A case of late-onset, thymoma-associated myasthenia gravis with ryanodine receptor and titin antibodies and concomitant granulomatous myositis. ( 27623618 )
2016
7
Sarcoidosis presenting as granulomatous myositis in a 16-year-old adolescent. ( 27832822 )
2016
8
LETTER TO THE EDITOR Atypical Granulomatous Myositis and Pulmonary Sarcoidosis. ( 26312107 )
2015
9
Diagnosis and classification of granulomatous myositis. ( 24424169 )
2014
10
A case of systemic anaplastic lymphoma kinase-negative anaplastic large cell lymphoma associated with hypereosinophilia, granulomatous myositis and vasculitis. ( 22519739 )
2012
11
Granulomatous myositis associated with brucellosis: a case report and literature review. ( 22246889 )
2012
12
Granulomatous myositis associated with a novel alveolate pathogen in an adult southern leopard frog (Lithobates sphenocephalus). ( 23269391 )
2012
13
Distal muscle involvement in granulomatous myositis can mimic inclusion body myositis. ( 20562458 )
2011
14
Granulomatous myositis mimicking slowly progressive lower motor neuron disease. ( 18700190 )
2008
15
Paediatric contracturing granulomatous myositis. ( 18821276 )
2008
16
Granulomatous myositis in association with chronic graft vs. host disease. ( 17970330 )
2007
17
Granulomatous myositis: a clinical study of thirteen cases. ( 17068767 )
2007
18
An autopsy case of aggressive CD30+ extra-nodal NK/T-cell lymphoma initially manifested with granulomatous myositis. ( 16321870 )
2006
19
Suppurative granulomatous myositis of an extra-ocular muscle in Crohn's disease. ( 16128967 )
2005
20
Granulomatous myositis: a manifestation of chronic graft-versus-host disease. ( 11904691 )
2002
21
Granulomatous myositis associated with antithyroglobulin and antithyroid peroxidase antibodies: an analogy to Hashimoto's encephalitis? ( 12532931 )
2002
22
Uptake of Ga-67 in granulomatous myositis with magnetic resonance imaging correlation. ( 11564935 )
2001
23
Granulomatous myositis, primary biliary cirrhosis, pancytopenia, and thymoma. ( 10883012 )
2000
24
Granulomatous myositis. Clinicopathologic study of 12 cases. ( 10396287 )
1999
25
Idiopathic granulomatous myositis: does the clinical spectrum include polymyalgia rheumatica? ( 18639165 )
1999
26
Granulomatous myositis: pathologic re-evaluation by immunohistochemical analysis of infiltrating mononuclear cells. ( 9073027 )
1997
27
Case report: MR features of granulomatous myositis. ( 9366543 )
1997
28
Tongue involvement in a patient with granulomatous myositis. ( 9305307 )
1997
29
[Granulomatous myositis during collagenosis (one case) and suprasellar dysgerminoma (one case) (author's transl)]. ( 482759 )
1979

Variations for Granulomatous Myositis

Expression for Granulomatous Myositis

Search GEO for disease gene expression data for Granulomatous Myositis.

Pathways for Granulomatous Myositis

Pathways related to Granulomatous Myositis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.1 TNFRSF1B TNFRSF8

GO Terms for Granulomatous Myositis

Cellular components related to Granulomatous Myositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 LYZ NCAM1 PRTN3 PTHLH TNFRSF1B TTN
2 extracellular exosome GO:0070062 9.17 LYZ NAIP NCAM1 PIK3C2A PRTN3 TNFRSF8

Biological processes related to Granulomatous Myositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.26 CD68 LYZ PRTN3 TNFRSF1B
2 inflammatory response GO:0006954 8.92 LYZ NAIP TNFRSF1B TNFRSF8

Molecular functions related to Granulomatous Myositis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF1B TNFRSF8

Sources for Granulomatous Myositis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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