GTCT
MCID: GRN022
MIFTS: 34

Granulosa Cell Tumor of the Ovary (GTCT)

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

MalaCards integrated aliases for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 20 6 70
Adult Granulosa Cell Tumor of the Ovary 20
Granulosa Theca Cell Tumor of the Ovary 20
Granulosa Theca Cell Tumor 20
Gct of the Ovary 20
Gtct 20

Classifications:



External Ids:

UMLS 70 C1370419

Summaries for Granulosa Cell Tumor of the Ovary

GARD : 20 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body. The symptoms of this excess estrogen depend on the woman's menstrual status ; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. The exact cause of granulosa cell tumors is unknown. Treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor.

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to amenorrhea and gynandroblastoma. An important gene associated with Granulosa Cell Tumor of the Ovary is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways are HIF-1 signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary, testis and small intestine, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 462)
# Related Disease Score Top Affiliating Genes
1 amenorrhea 30.8 PRL INS FOXL2
2 gynandroblastoma 30.6 VIM FOXL2
3 ovarian sex-cord stromal tumor 30.4 KRT7 FOXL2
4 ovarian germ cell teratoma 30.4 SYP KRT7
5 leydig cell tumor 30.3 SYP PRL INHA
6 papillary carcinoma 30.1 SYP KRT7 ERBB2 CHGA
7 sertoli-leydig cell tumor 30.1 SYP KRT7 INHA ENO2
8 endodermal sinus tumor 29.9 VIM SERPINA1 KRT7 INHA CHGA
9 granular cell tumor 29.9 VIM SYP INHA ENO2
10 cystadenoma 29.9 SYP KRT7 INHA CHGA CEACAM3
11 signet ring cell adenocarcinoma 29.9 TP53 KRT7 ERBB2 CHGA
12 leiomyosarcoma 29.8 VIM TP53 ENO2 ACTC1
13 cystic teratoma 29.7 TP53 SYP KRT7 ENO2
14 sertoli cell tumor 29.7 VIM SYP KRT7 INHA ENO2
15 premature menopause 29.4 TP53 PRL INS INHA FOXL2
16 endometrial cancer 29.4 TP53 TERT KRT7 INS INHA ERBB2
17 small cell carcinoma 29.2 TP53 SYP KRT7 ERBB2 ENO2 CHGA
18 tuberous sclerosis 29.1 VIM TP53 SYP INS ENO2 CHGA
19 teratoma 29.0 TP53 SYP KRT7 INS ENO2 CHGA
20 maligant granulosa cell tumor of the ovary 11.5
21 juvenile type testicular granulosa cell tumor 10.9
22 precocious puberty 10.6
23 endometrial hyperplasia 10.5
24 rare tumor 10.5
25 vaginal glandular tumor 10.4 ENO2 CHGA
26 ureter transitional cell carcinoma 10.4 ENO2 CHGA
27 fibroma 10.4
28 chromosomal triplication 10.4
29 gastric gastrinoma 10.4 ENO2 CHGA
30 nodular ganglioneuroblastoma 10.4 ENO2 CHGA
31 goblet cell carcinoid 10.4 ENO2 CHGA
32 appendix lymphoma 10.3 ENO2 CHGA
33 female urethral cancer 10.3 KRT7 CHGA
34 retroperitoneal hemangiopericytoma 10.3 INS ENO2
35 oncocytic breast carcinoma 10.3 KRT7 ERBB2
36 ovarian cyst 10.3
37 testicular yolk sac tumor 10.3
38 monosomy 22 10.3
39 appendiceal neoplasm 10.3 KRT7 CHGA
40 vulva adenocarcinoma 10.3 KRT7 ERBB2
41 vulval paget's disease 10.3 KRT7 ERBB2
42 breast leiomyosarcoma 10.3 KRT7 ENO2
43 lipid-rich breast carcinoma 10.3 PRL ERBB2
44 vulvar apocrine adenocarcinoma 10.3 KRT7 ENO2
45 lymphangiectasis 10.3 VIM ACTC1
46 ectopic cushing syndrome 10.3 PRL CHGA
47 head injury 10.3 PRL ENO2
48 intravascular papillary endothelial hyperplasia 10.3 VIM ACTC1
49 breast metaplastic carcinoma 10.3 KRT7 ERBB2
50 pulmonary artery leiomyosarcoma 10.3 KRT7 ENO2

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 ACTC1 CHGA CP ERBB2 FOXL2 GNAI2
2 endocrine/exocrine gland MP:0005379 10.06 CHGA ERBB2 FOXL2 GNAI2 INHA INS
3 nervous system MP:0003631 9.93 ACTC1 CHGA CP ENO2 ERBB2 GNAI2
4 liver/biliary system MP:0005370 9.87 CP GNAI2 INHA INS PRL TERT
5 neoplasm MP:0002006 9.73 ERBB2 GNAI2 INHA PRL TERT TP53
6 normal MP:0002873 9.7 ACTC1 ERBB2 FOXL2 GNAI2 INHA INS
7 reproductive system MP:0005389 9.28 CHGA ERBB2 FOXL2 INHA INS PRL

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Search Clinical Trials , NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

40
Ovary, Testis, Small Intestine, Colon, Adrenal Gland, Uterus, Pituitary

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 270)
# Title Authors PMID Year
1
Two G protein oncogenes in human endocrine tumors. 6
2116665 1990
2
Juvenile granulosa cell tumor of the ovary: A comprehensive clinicopathologic analysis of 15 cases. 61
33725665 2021
3
Radiographic and Tumor Biomarker Response to Radiotherapy for Recurrent Granulosa Cell Tumor of the Ovary. 61
33728159 2021
4
Adult-type granulosa cell tumor of the ovary: a FOXL2-centric disease. 61
33428330 2021
5
Management of recurrent granulosa cell tumor of the ovary: Contemporary literature review and a proposal of hyperthermic intraperitoneal chemotherapy as novel therapeutic option. 61
33103312 2021
6
Magnetic Resonance Imaging of Recurrent Adult Granulosa Cell Tumor of the Ovary: A Retrospective Analysis of 11 Cases. 61
32976259 2020
7
Active immunisation against GnRH as treatment for unilateral granulosa theca cell tumour in mares. 61
32924167 2020
8
Torsion of Granulosa Cell Tumor of the Ovary in a Preschool Patient: A Rare Cause of Acute Abdomen. 61
32335578 2020
9
Granulosa Cell Tumor of the Ovary Accompanying with Ollier's Disease: First Case of Contralateral Presentations. 61
32030011 2020
10
Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary. 61
32059683 2020
11
Endocrinological characterization of an ovarian sex cord-stromal tumor with a Sertoli cell pattern in a Japanese Black cow. 61
31448448 2019
12
Aggressive adult granulosa cell tumor of the ovary without a FOXL2 mutation: A case report. 61
30950114 2019
13
Correction: TERT promoter mutation in adult granulosa cell tumor of the ovary. 61
29968850 2019
14
Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report. 61
30655270 2019
15
A Small Granulosa Cell Tumor of the Ovary Incidentally Detected on Diffusion-weighted Images. 61
30146532 2019
16
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. 61
30547828 2018
17
TERT promoter mutation in adult granulosa cell tumor of the ovary. 61
29449679 2018
18
Endogenous c-Jun N-terminal kinase (JNK) activity marks the boundary between normal and malignant granulosa cells. 61
29549247 2018
19
Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary? 61
29587835 2018
20
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. 61
29796312 2018
21
Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted? 61
29055817 2017
22
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. 61
28276867 2017
23
Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. 61
28851436 2017
24
Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports. 61
28637499 2017
25
Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary. 61
28476811 2017
26
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. 61
27702598 2017
27
Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. 61
28594898 2017
28
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. 61
27493080 2016
29
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. 61
27297428 2016
30
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. 61
27324782 2016
31
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. 61
26956549 2016
32
Granulosa cell tumor of the ovary. 61
28757730 2016
33
Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy for recurrent adult granulosa cell tumor: A case report. 61
27331130 2016
34
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. 61
24934781 2016
35
[Diagnosis and follow-up observation of granulosa cell tumor of the ovary are becoming more precise]. 61
27400589 2016
36
Endometrial Carcinoma Associated with Ovarian Granulosa Cell Tumors--A Case Report. 61
26408724 2015
37
Evidence of Spontaneous Recovery of Granulosa-Theca Cell Tumour in a Heifer: A Retrospective Report. 61
26095590 2015
38
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. 61
25621056 2015
39
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. 61
27323838 2015
40
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. 61
25979613 2015
41
Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: family based association study. 61
25448703 2015
42
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. 61
24656706 2014
43
Granulosa cell tumor of ovary: A clinicopathological study of four cases with brief review of literature. 61
25316999 2014
44
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. 61
24630126 2014
45
[Granulosa cell tumor of the ovary: retrospective study of 17 cases]. 61
24394321 2014
46
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. 61
25556264 2014
47
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. 61
25219997 2014
48
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. 61
25339044 2014
49
Ovarian granulosa cell tumor and increased risk of breast cancer. 61
24283356 2013
50
Polymorphisms in the IL2RA and IL2RB genes in inflammatory bowel disease risk. 61
23972291 2013

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 GNAI2 NM_002070.4(GNAI2):c.535C>T (p.Arg179Cys) SNV Pathogenic 15903 rs137853226 GRCh37: 3:50293694-50293694
GRCh38: 3:50256262-50256262
2 GNAI2 NM_002070.4(GNAI2):c.536G>A (p.Arg179His) SNV Pathogenic 15904 rs137853227 GRCh37: 3:50293695-50293695
GRCh38: 3:50256263-50256263

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 INS ERBB2 ENO2
2 11.05 VIM TERT SERPINA1 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 SERPINA1 PRL INS INHA ENO2 CP

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 VIM TP53 INS ERBB2 ACTC1
2 cellular protein metabolic process GO:0044267 9.46 SERPINA1 PRL INS CP
3 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.32 TP53 TERT
4 negative regulation of blood vessel diameter GO:0097756 8.96 INS CHGA
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.8 TP53 TERT PRL

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 TP53 SERPINA1 INS
2 identical protein binding GO:0042802 9.17 VIM TP53 TERT SYP SERPINA1 INS
3 chaperone binding GO:0051087 9.13 TP53 TERT CP

Sources for Granulosa Cell Tumor of the Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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