GTCT
MCID: GRN022
MIFTS: 36

Granulosa Cell Tumor of the Ovary (GTCT)

Categories: Rare diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

MalaCards integrated aliases for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 53 6 73
Adult Granulosa Cell Tumor of the Ovary 53
Granulosa Theca Cell Tumor of the Ovary 53
Granulosa Theca Cell Tumor 53
Gct of the Ovary 53
Gtct 53

Classifications:



External Ids:

UMLS 73 C1370419

Summaries for Granulosa Cell Tumor of the Ovary

NIH Rare Diseases : 53 Granulosa celltumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  The symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. The exact cause of granulosa cell tumors is unknown.  Treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor.

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to gynandroblastoma and sertoli cell tumor. An important gene associated with Granulosa Cell Tumor of the Ovary is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways is HIF-1 signaling pathway. The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and liver, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 30.6 FOXL2 VIM
2 sertoli cell tumor 30.3 INHA SYP VIM
3 cystic teratoma 30.1 ENO2 KRT7 SYP TP53
4 teratoma 30.0 ACTC1 ENO2 KRT7 SYP TP53
5 maligant granulosa cell tumor of the ovary 12.5
6 juvenile type testicular granulosa cell tumor 10.8
7 spindle cell lipoma 10.3 ACTC1 VIM
8 angiolipoma 10.3 ACTC1 VIM
9 cutaneous leiomyosarcoma 10.3 ACTC1 VIM
10 glomangiomyoma 10.3 ACTC1 VIM
11 intravascular papillary endothelial hyperplasia 10.3 ACTC1 VIM
12 ependymoblastoma 10.3 TP53 VIM
13 malignant giant cell tumor 10.3 ACTC1 TP53
14 pleomorphic adenoma carcinoma 10.3 ERBB2 TP53
15 uterine body mixed cancer 10.3 ERBB2 TP53
16 breast squamous cell carcinoma 10.3 ERBB2 TP53
17 gastric papillary adenocarcinoma 10.3 ERBB2 TP53
18 non-proliferative fibrocystic change of the breast 10.3 ERBB2 TP53
19 clear cell meningioma 10.3 CHGA VIM
20 uterine corpus serous adenocarcinoma 10.3 ERBB2 TP53
21 epulis 10.3 ENO2 VIM
22 bednar tumor 10.3 ENO2 VIM
23 fibroepithelial basal cell carcinoma 10.3 CHGA TP53
24 nodular hidradenoma 10.3 KRT7 VIM
25 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 VIM
26 papillary adenoma 10.3 KRT7 VIM
27 secretory meningioma 10.3 KRT7 VIM
28 bile duct adenoma 10.3 KRT7 VIM
29 monophasic synovial sarcoma 10.3 KRT7 VIM
30 adenoid squamous cell carcinoma 10.3 KRT7 VIM
31 vulval paget's disease 10.3 ERBB2 KRT7
32 vulvar disease 10.3 KRT7 TP53
33 papillary serous adenocarcinoma 10.3 KRT7 TP53
34 acute thyroiditis 10.3 CHGA ENO2
35 nasal cavity adenocarcinoma 10.3 KRT7 TP53
36 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
37 malignant spiradenoma 10.3 KRT7 TP53
38 lung oat cell carcinoma 10.3 CHGA ENO2
39 bladder carcinoma in situ 10.3 KRT7 TP53
40 vulvar intraepithelial neoplasia 10.3 KRT7 TP53
41 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA ENO2
42 goblet cell carcinoid 10.3 CHGA ENO2
43 atrial septal defect 5 10.3 ACTC1 INS
44 papillary transitional carcinoma 10.2 ENO2 KRT7
45 microcystic adenoma 10.2 ENO2 INHA
46 insulinomatosis and diabetes mellitus 10.2 CHGA INS
47 dermatofibrosarcoma protuberans 10.2 ACTC1 TP53 VIM
48 inflammatory myofibroblastic tumor 10.2 ACTC1 TP53 VIM
49 epithelioid trophoblastic tumor 10.2 INHA KRT7
50 malignant peripheral nerve sheath tumor 10.2 ACTC1 TP53 VIM

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 CP ENO2 ERBB2 GNAI2 INS PRL
2 homeostasis/metabolism MP:0005376 10.03 ACTC1 CHGA CP ERBB2 FOXL2 GNAI2
3 cardiovascular system MP:0005385 10.02 ACTC1 CHGA CP ERBB2 GNAI2 INHA
4 endocrine/exocrine gland MP:0005379 9.92 CHGA ERBB2 FOXL2 GNAI2 INHA INS
5 nervous system MP:0003631 9.85 CHGA CP ENO2 ERBB2 GNAI2 INS
6 normal MP:0002873 9.56 ACTC1 ERBB2 FOXL2 GNAI2 INHA INS
7 reproductive system MP:0005389 9.23 CHGA ERBB2 FOXL2 INHA INS PRL

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Drugs for Granulosa Cell Tumor of the Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
5
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
6
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
7
Ketoconazole Approved, Investigational Phase 2 65277-42-1 3823 47576
8
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
9 Antineoplastic Agents, Phytogenic Phase 2
10 Antimitotic Agents Phase 2
11 Albumin-Bound Paclitaxel Phase 2
12 Immunologic Factors Phase 2
13 Mitogens Phase 2
14 Immunoglobulin G Phase 2
15 Immunoglobulins Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Antibodies, Monoclonal Phase 2
18 Endothelial Growth Factors Phase 2
19 Angiogenesis Inhibitors Phase 2
20 Antibodies Phase 2
21 Anti-Bacterial Agents Phase 2
22 Etoposide phosphate Phase 2
23 Antibiotics, Antitubercular Phase 2
24 Topoisomerase Inhibitors Phase 2
25 Cytochrome P-450 Enzyme Inhibitors Phase 2
26 Anti-Infective Agents Phase 2
27 Steroid Synthesis Inhibitors Phase 2
28 Antifungal Agents Phase 2
29 Cytochrome P-450 CYP3A Inhibitors Phase 2
30 Hormone Antagonists Phase 2
31 Hormones Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
3 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
4 Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary Terminated NCT01584297 Phase 2 Ketoconazole

Search NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

41
Ovary, Lung, Liver, Kidney, Pituitary, Thymus, Pineal

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 147)
# Title Authors Year
1
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. ( 29796312 )
2018
2
TERT promoter mutation in adult granulosa cell tumor of the ovary. ( 29449679 )
2018
3
Correction: TERT promoter mutation in adult granulosa cell tumor of the ovary. ( 29968850 )
2018
4
Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary? ( 29587835 )
2018
5
A Small Granulosa Cell Tumor of the Ovary Incidentally Detected on Diffusion-weighted Images. ( 30146532 )
2018
6
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. ( 30547828 )
2018
7
Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. ( 28851436 )
2017
8
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
9
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. ( 28276867 )
2017
10
Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted? ( 29055817 )
2017
11
Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. ( 28594898 )
2017
12
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. ( 27493080 )
2016
13
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. ( 27297428 )
2016
14
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. ( 26956549 )
2016
15
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. ( 27324782 )
2016
16
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. ( 27323838 )
2016
17
Granulosa cell tumor of the ovary. ( 28757730 )
2016
18
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. ( 25979613 )
2015
19
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. ( 25621056 )
2015
20
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. ( 25219997 )
2014
21
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. ( 24630126 )
2014
22
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
23
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. ( 25339044 )
2014
24
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. ( 24934781 )
2014
25
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. ( 25556264 )
2014
26
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report. ( 24051926 )
2013
27
Granulosa cell tumor of the ovary with high FDG uptake. ( 23640219 )
2013
28
The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. ( 24257556 )
2013
29
A case of granulosa cell tumor of the ovary detected from metastatic foci. ( 23327064 )
2012
30
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. ( 22175649 )
2012
31
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
32
Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary. ( 23268102 )
2012
33
Ruptured granulosa cell tumor of the ovary as a cause of acute abdomen in postmenopausal woman. ( 22973526 )
2012
34
Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene. ( 22612286 )
2012
35
Granulosa cell tumor of the ovary: time to launch a new prospective trial. ( 21998755 )
2011
36
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. ( 21998767 )
2011
37
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. ( 22335040 )
2011
38
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. ( 21843743 )
2011
39
Delayed menopause due to granulosa cell tumor of the ovary. ( 22408338 )
2011
40
Neoadjuvant bevacizumab in a granulosa cell tumor of the ovary: a case report. ( 21115938 )
2010
41
Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer. ( 20704728 )
2010
42
Late recurrence of granulosa cell tumor of the ovary with synchronous gastric signet-ring cell carcinoma. ( 21229651 )
2010
43
Unusual presentation of granulosa cell tumor of the ovary. ( 20713871 )
2010
44
Nearly 30 Years of Treatment for Recurrent Granulosa Cell Tumor of the Ovary: A Case Report and Review of the Literature. ( 20740152 )
2010
45
Fine needle aspiration of metastatic adult granulosa cell tumor of the ovary: a case report. ( 21053572 )
2010
46
Granulosa cell tumor of the ovary: cytologic findings. ( 20715655 )
2010
47
An Unusual Case of Juvenile Granulosa Cell Tumor of the Ovary. ( 27843515 )
2009
48
Isolated breast metastasis from granulosa cell tumor of the ovary. ( 19306013 )
2009
49
Prognostic factors in adult granulosa cell tumor of the ovary. ( 19198715 )
2009
50
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. ( 19225930 )
2009

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh37 Chromosome 3, 50293694: 50293694
2 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh38 Chromosome 3, 50256262: 50256262
3 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh37 Chromosome 3, 50293695: 50293695
4 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh38 Chromosome 3, 50256263: 50256263

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 ENO2 ERBB2 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ACTC1 CHGA CP ENO2 INHA INS
2 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.46 CP INS PRL SERPINA1
2 positive regulation of insulin receptor signaling pathway GO:0046628 9.32 GNAI2 INS
3 negative regulation of blood vessel diameter GO:0097756 9.26 CHGA INS
4 positive regulation of gene expression GO:0010628 9.02 ACTC1 ERBB2 INS TP53 VIM
5 positive regulation of follicle-stimulating hormone secretion GO:0046881 8.96 FOXL2 INHA

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 INHA INS PRL
2 protease binding GO:0002020 9.13 INS SERPINA1 TP53
3 identical protein binding GO:0042802 9.1 ERBB2 INS SERPINA1 SYP TP53 VIM

Sources for Granulosa Cell Tumor of the Ovary

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