MCID: GRN022
MIFTS: 41

Granulosa Cell Tumor of the Ovary

Categories: Rare diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

MalaCards integrated aliases for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 53 6 73
Adult Granulosa Cell Tumor of the Ovary 53
Granulosa Theca Cell Tumor of the Ovary 53
Granulosa Theca Cell Tumor 53
Gct of the Ovary 53
Gtct 53

Classifications:



External Ids:

UMLS 73 C1370419

Summaries for Granulosa Cell Tumor of the Ovary

NIH Rare Diseases : 53 Granulosa celltumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  The symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. The exact cause of granulosa cell tumors is unknown.  Treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor.

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to gynandroblastoma and sertoli cell tumor. An important gene associated with Granulosa Cell Tumor of the Ovary is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways is HIF-1 signaling pathway. The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and breast, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 31.3 FOXL2 VIM
2 sertoli cell tumor 30.6 INHA SYP VIM
3 maligant granulosa cell tumor of the ovary 12.3
4 lymphangiectasis 10.9 ACTC1 VIM
5 glomangiomyoma 10.9 ACTC1 VIM
6 gallbladder squamous cell carcinoma 10.9 ERBB2 TP53
7 gastric papillary adenocarcinoma 10.9 ERBB2 TP53
8 angiolipoma 10.9 ACTC1 VIM
9 intravascular papillary endothelial hyperplasia 10.9 ACTC1 VIM
10 bednar tumor 10.9 ENO2 VIM
11 uterine corpus serous adenocarcinoma 10.9 ERBB2 TP53
12 primitive neuroectodermal tumor of the cervix uteri 10.9 ENO2 VIM
13 spindle cell lipoma 10.8 ACTC1 VIM
14 malignant giant cell tumor 10.8 ACTC1 TP53
15 breast neuroendocrine neoplasm 10.8 ERBB2 SYP
16 epulis 10.8 ENO2 VIM
17 congenital granular cell tumor 10.8 ENO2 SERPINA1
18 malignant sertoli cell tumor 10.8 ENO2 SYP
19 syringocystadenoma papilliferum 10.8 ACTC1 VIM
20 rhabdoid meningioma 10.8 SYP VIM
21 non-proliferative fibrocystic change of the breast 10.8 ERBB2 TP53
22 intracystic papillary adenoma 10.7 ERBB2 PRL
23 pancreatic somatostatinoma 10.7 ENO2 SYP
24 cutaneous ganglioneuroma 10.7 ENO2 SYP
25 ependymoblastoma 10.7 TP53 VIM
26 extrahepatic bile duct adenocarcinoma 10.7 ENO2 SYP
27 orbital cancer 10.7 ENO2 SYP
28 intracranial primitive neuroectodermal tumor 10.7 CHGA ENO2
29 ovarian carcinosarcoma 10.7 ENO2 SYP
30 choriocarcinoma of ovary 10.7 ENO2 PRL
31 esophageal neuroendocrine tumor 10.7 CHGA SYP
32 olfactory groove meningioma 10.7 CHGA TP53
33 juvenile type testicular granulosa cell tumor 10.7
34 ossifying fibromyxoid tumor 10.6 ACTC1 ENO2 VIM
35 epithelioid leiomyosarcoma 10.6 ACTC1 ENO2 VIM
36 pleomorphic adenoma carcinoma 10.6 ENO2 ERBB2 TP53
37 liver angiosarcoma 10.6 ENO2 TP53 VIM
38 subependymal glioma 10.6 ENO2 SYP
39 dermatofibrosarcoma protuberans 10.6 ACTC1 TP53 VIM
40 inflammatory myofibroblastic tumor 10.6 ACTC1 TP53 VIM
41 prolactin producing pituitary tumor 10.6 PRL TP53
42 malignant peripheral nerve sheath tumor 10.6 ACTC1 TP53 VIM
43 epithelioid malignant peripheral nerve sheath tumor 10.6 CHGA ENO2
44 peritoneal serous adenocarcinoma 10.6 CHGA SYP
45 glomangioma 10.6 ACTC1 ENO2 VIM
46 angiocentric glioma 10.6 ACTC1 SYP VIM
47 malignant spiradenoma 10.6 KRT7 TP53
48 papillary tumor of the pineal region 10.6 ENO2 SYP VIM
49 goblet cell carcinoid 10.6 CHGA ENO2
50 gastrointestinal neuroendocrine tumor 10.6 CHGA SYP

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 ACTC1 CHGA CP TP53 ERBB2 VIM
2 homeostasis/metabolism MP:0005376 9.93 CHGA KRT7 PRL CP TP53 ERBB2
3 endocrine/exocrine gland MP:0005379 9.86 INS CHGA PRL TP53 ERBB2 FOXL2
4 normal MP:0002873 9.56 INS ACTC1 SYP TP53 ERBB2 FOXL2
5 reproductive system MP:0005389 9.23 INS CHGA PRL TP53 ERBB2 VIM

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Drugs for Granulosa Cell Tumor of the Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
6
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
7
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
8
Ketoconazole Approved, Investigational Phase 2 65277-42-1 47576 3823
9 Mitogens Phase 2
10 Albumin-Bound Paclitaxel Phase 2
11 Angiogenesis Inhibitors Phase 2
12 Angiogenesis Modulating Agents Phase 2
13 Endothelial Growth Factors Phase 2
14 Immunoglobulin G Phase 2
15 Antibodies Phase 2
16 Immunoglobulins Phase 2
17 Antibodies, Monoclonal Phase 2
18 Antimitotic Agents Phase 2
19 Antineoplastic Agents, Phytogenic Phase 2
20 Topoisomerase Inhibitors Phase 2
21 Anti-Bacterial Agents Phase 2
22 Antibiotics, Antitubercular Phase 2
23 Etoposide phosphate Phase 2
24 Steroid Synthesis Inhibitors Phase 2
25 Cytochrome P-450 CYP3A Inhibitors Phase 2
26 Cytochrome P-450 Enzyme Inhibitors Phase 2
27 Hormone Antagonists Phase 2
28 Hormones Phase 2
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
30 Anti-Infective Agents Phase 2
31 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
3 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
4 Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary Terminated NCT01584297 Phase 2 Ketoconazole

Search NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

41
Ovary, Endothelial, Breast, Adrenal Gland, Liver, Lung, Bone

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 159)
# Title Authors Year
1
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. ( 29796312 )
2018
2
TERT promoter mutation in adult granulosa cell tumor of the ovary. ( 29449679 )
2018
3
Correction: TERT promoter mutation in adult granulosa cell tumor of the ovary. ( 29968850 )
2018
4
Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary? ( 29587835 )
2018
5
Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. ( 28851436 )
2017
6
Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary. ( 28476811 )
2017
7
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
8
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. ( 28276867 )
2017
9
Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted? ( 29055817 )
2017
10
Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. ( 28594898 )
2017
11
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. ( 27493080 )
2016
12
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. ( 27297428 )
2016
13
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. ( 26956549 )
2016
14
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. ( 27324782 )
2016
15
Granulosa cell tumor of the ovary. ( 28757730 )
2016
16
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. ( 27323838 )
2016
17
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. ( 25979613 )
2015
18
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. ( 25621056 )
2015
19
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. ( 25219997 )
2014
20
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. ( 24630126 )
2014
21
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
22
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. ( 25339044 )
2014
23
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. ( 24934781 )
2014
24
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. ( 25556264 )
2014
25
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report. ( 24051926 )
2013
26
Granulosa cell tumor of the ovary with high FDG uptake. ( 23640219 )
2013
27
The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. ( 24257556 )
2013
28
A case of granulosa cell tumor of the ovary detected from metastatic foci. ( 23327064 )
2012
29
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. ( 22175649 )
2012
30
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
31
Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary. ( 23268102 )
2012
32
Ruptured granulosa cell tumor of the ovary as a cause of acute abdomen in postmenopausal woman. ( 22973526 )
2012
33
Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene. ( 22612286 )
2012
34
Granulosa cell tumor of the ovary: time to launch a new prospective trial. ( 21998755 )
2011
35
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. ( 21998767 )
2011
36
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. ( 22335040 )
2011
37
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary. ( 21623383 )
2011
38
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. ( 22200085 )
2011
39
Delayed menopause due to granulosa cell tumor of the ovary. ( 22408338 )
2011
40
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. ( 21843743 )
2011
41
Role of adjuvant radiotherapy in granulosa cell tumors of the ovary. ( 20472362 )
2011
42
Neoadjuvant bevacizumab in a granulosa cell tumor of the ovary: a case report. ( 21115938 )
2010
43
Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer. ( 20704728 )
2010
44
Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency. ( 20395670 )
2010
45
Late recurrence of granulosa cell tumor of the ovary with synchronous gastric signet-ring cell carcinoma. ( 21229651 )
2010
46
Granulosa cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 21 cases. ( 20349790 )
2010
47
Unusual presentation of granulosa cell tumor of the ovary. ( 20713871 )
2010
48
Nearly 30 Years of Treatment for Recurrent Granulosa Cell Tumor of the Ovary: A Case Report and Review of the Literature. ( 20740152 )
2010
49
Fine needle aspiration of metastatic adult granulosa cell tumor of the ovary: a case report. ( 21053572 )
2010
50
Granulosa cell tumor of the ovary: cytologic findings. ( 20715655 )
2010

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh37 Chromosome 3, 50293694: 50293694
2 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh38 Chromosome 3, 50256262: 50256262
3 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh37 Chromosome 3, 50293695: 50293695
4 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh38 Chromosome 3, 50256263: 50256263

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 ENO2 ERBB2 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ACTC1 CHGA CP ENO2 INHA INS
2 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.46 CP INS PRL SERPINA1
2 positive regulation of insulin receptor signaling pathway GO:0046628 9.32 GNAI2 INS
3 negative regulation of blood vessel diameter GO:0097756 9.26 CHGA INS
4 positive regulation of gene expression GO:0010628 9.02 ACTC1 ERBB2 INS TP53 VIM
5 positive regulation of follicle-stimulating hormone secretion GO:0046881 8.96 FOXL2 INHA

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 INHA INS PRL
2 protease binding GO:0002020 9.13 INS SERPINA1 TP53
3 identical protein binding GO:0042802 9.1 ERBB2 INS SERPINA1 SYP TP53 VIM

Sources for Granulosa Cell Tumor of the Ovary

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