GTCT
MCID: GRN022
MIFTS: 34

Granulosa Cell Tumor of the Ovary (GTCT)

Categories: Rare diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

MalaCards integrated aliases for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 52 6 71
Adult Granulosa Cell Tumor of the Ovary 52
Granulosa Theca Cell Tumor of the Ovary 52
Granulosa Theca Cell Tumor 52
Gct of the Ovary 52
Gtct 52

Classifications:



External Ids:

UMLS 71 C1370419

Summaries for Granulosa Cell Tumor of the Ovary

NIH Rare Diseases : 52 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body. The symptoms of this excess estrogen depend on the woman's menstrual status ; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. The exact cause of granulosa cell tumors is unknown. Treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor.

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to gynandroblastoma and fibroma. An important gene associated with Granulosa Cell Tumor of the Ovary is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways are HIF-1 signaling pathway and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Affiliated tissues include ovary, breast and liver, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 469)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 30.9 VIM FOXL2
2 fibroma 30.9 VIM KRT7 ACTC1
3 amenorrhea 30.7 PRL INS FOXL2
4 leiomyosarcoma 30.5 VIM TP53 ENO2 ACTC1
5 ovarian sex-cord stromal tumor 30.3 KRT7 FOXL2
6 signet ring cell adenocarcinoma 30.0 TP53 KRT7 ERBB2 CHGA
7 endodermal sinus tumor 30.0 VIM SERPINA1 KRT7 CHGA
8 ovarian disease 30.0 TP53 PRL INS FOXL2 ERBB2
9 transitional cell carcinoma 29.9 TP53 KRT7 ERBB2 ENO2
10 ovarian germ cell teratoma 29.7 SYP KRT7
11 hemangiopericytoma, malignant 29.6 VIM SYP ENO2 ACTC1
12 cystic teratoma 29.5 TP53 SYP KRT7 ENO2
13 granular cell tumor 29.5 VIM SYP INHA ENO2
14 papillary carcinoma 29.4 SYP KRT7 ERBB2 CHGA
15 endometrial cancer 29.2 TP53 TERT KRT7 INS INHA ERBB2
16 sertoli-leydig cell tumor 29.2 SYP KRT7 INHA FOXL2 ENO2
17 sertoli cell tumor 29.2 VIM SYP KRT7 INHA ENO2
18 small cell carcinoma 29.0 TP53 SYP KRT7 ENO2 CHGA
19 cystadenoma 29.0 SYP KRT7 INHA CHGA CEACAM3
20 tuberous sclerosis 28.8 VIM TP53 SYP INS ENO2 CHGA
21 teratoma 28.0 VIM TP53 SYP KRT7 INS ENO2
22 maligant granulosa cell tumor of the ovary 12.6
23 juvenile type testicular granulosa cell tumor 10.8
24 lymphangiectasis 10.6 VIM ACTC1
25 intravascular papillary endothelial hyperplasia 10.5 VIM ACTC1
26 precocious puberty 10.5
27 endometrial hyperplasia 10.5
28 gastric papillary adenocarcinoma 10.5 TP53 ERBB2
29 primitive neuroectodermal tumor of the cervix uteri 10.5 VIM ENO2
30 apocrine adenosis of breast 10.5 TP53 ERBB2
31 bednar tumor 10.5 VIM ENO2
32 rare tumor 10.5
33 cutaneous leiomyosarcoma 10.5 VIM ACTC1
34 breast myoepithelial carcinoma 10.4 VIM ACTC1
35 comedo carcinoma 10.4 TP53 ERBB2
36 congenital epulis 10.4 VIM ENO2
37 bizarre leiomyoma 10.4 TP53 ACTC1
38 epulis 10.4 VIM ENO2
39 parotid gland cancer 10.4 TP53 ERBB2
40 adult teratoma 10.4 TP53 CHGA
41 vaginal glandular tumor 10.4 ENO2 CHGA
42 liver angiosarcoma 10.4 VIM TP53
43 breast adenoid cystic carcinoma 10.4 TP53 ERBB2
44 chondroid chordoma 10.4 VIM CEACAM3
45 ureter transitional cell carcinoma 10.4 ENO2 CHGA
46 pleomorphic adenoma carcinoma 10.4 TP53 ERBB2
47 benign pleural mesothelioma 10.4 TP53 INS
48 goblet cell carcinoid 10.4 ENO2 CHGA
49 gastric gastrinoma 10.4 ENO2 CHGA
50 nodular ganglioneuroblastoma 10.4 ENO2 CHGA

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 ACTC1 CHGA CP ERBB2 FOXL2 GNAI2
2 cellular MP:0005384 10.13 ACTC1 CP ENO2 ERBB2 GNAI2 INS
3 cardiovascular system MP:0005385 10.11 ACTC1 CHGA CP ERBB2 GNAI2 INHA
4 endocrine/exocrine gland MP:0005379 10.06 CHGA ERBB2 FOXL2 GNAI2 INHA INS
5 nervous system MP:0003631 9.93 ACTC1 CHGA CP ENO2 ERBB2 GNAI2
6 liver/biliary system MP:0005370 9.87 CP GNAI2 INHA INS PRL TERT
7 neoplasm MP:0002006 9.73 ERBB2 GNAI2 INHA PRL TERT TP53
8 normal MP:0002873 9.65 ACTC1 ERBB2 FOXL2 GNAI2 INHA INS
9 reproductive system MP:0005389 9.28 CHGA ERBB2 FOXL2 INHA INS PRL

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Search Clinical Trials , NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

40
Ovary, Breast, Liver, Testis, Colon, Bone, Small Intestine

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 264)
# Title Authors PMID Year
1
Two G protein oncogenes in human endocrine tumors. 6
2116665 1990
2
Torsion of Granulosa Cell Tumor of the Ovary in a Preschool Patient: A Rare Cause of Acute Abdomen. 61
32335578 2020
3
Granulosa Cell Tumor of the Ovary Accompanying with Ollier's Disease: First Case of Contralateral Presentations. 61
32030011 2020
4
Characteristics and treatment results of recurrence in adult-type granulosa cell tumor of ovary. 61
32059683 2020
5
Endocrinological characterization of an ovarian sex cord-stromal tumor with a Sertoli cell pattern in a Japanese Black cow. 61
31448448 2019
6
Aggressive adult granulosa cell tumor of the ovary without a FOXL2 mutation: A case report. 61
30950114 2019
7
A Small Granulosa Cell Tumor of the Ovary Incidentally Detected on Diffusion-weighted Images. 61
30146532 2019
8
Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report. 61
30655270 2019
9
Correction: TERT promoter mutation in adult granulosa cell tumor of the ovary. 61
29968850 2019
10
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. 61
30547828 2018
11
TERT promoter mutation in adult granulosa cell tumor of the ovary. 61
29449679 2018
12
Endogenous c-Jun N-terminal kinase (JNK) activity marks the boundary between normal and malignant granulosa cells. 61
29549247 2018
13
Is adjuvant chemotherapy beneficial for patients with FIGO stage IC adult granulosa cell tumor of the ovary? 61
29587835 2018
14
Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. 61
29796312 2018
15
Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted? 61
29055817 2017
16
Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. 61
28851436 2017
17
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. 61
28276867 2017
18
Diagnostic relevance of urinary steroid profiles on ovarian granulosa cell tumors: two case reports. 61
28637499 2017
19
Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary. 61
28476811 2017
20
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. 61
27702598 2017
21
Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. 61
28594898 2017
22
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. 61
27493080 2016
23
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. 61
27324782 2016
24
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. 61
27297428 2016
25
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. 61
26956549 2016
26
Granulosa cell tumor of the ovary. 61
28757730 2016
27
Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy for recurrent adult granulosa cell tumor: A case report. 61
27331130 2016
28
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. 61
24934781 2016
29
[Diagnosis and follow-up observation of granulosa cell tumor of the ovary are becoming more precise]. 61
27400589 2016
30
Endometrial Carcinoma Associated with Ovarian Granulosa Cell Tumors--A Case Report. 61
26408724 2015
31
Evidence of Spontaneous Recovery of Granulosa-Theca Cell Tumour in a Heifer: A Retrospective Report. 61
26095590 2015
32
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. 61
27323838 2015
33
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. 61
25621056 2015
34
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. 61
25979613 2015
35
Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: family based association study. 61
25448703 2015
36
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. 61
24656706 2014
37
Granulosa cell tumor of ovary: A clinicopathological study of four cases with brief review of literature. 61
25316999 2014
38
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. 61
24630126 2014
39
[Granulosa cell tumor of the ovary: retrospective study of 17 cases]. 61
24394321 2014
40
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. 61
25556264 2014
41
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. 61
25219997 2014
42
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. 61
25339044 2014
43
Ovarian granulosa cell tumor and increased risk of breast cancer. 61
24283356 2013
44
Polymorphisms in the IL2RA and IL2RB genes in inflammatory bowel disease risk. 61
23972291 2013
45
Plasma anti-Müllerian hormone as a biomarker for bovine granulosa-theca cell tumors: comparison with immunoreactive inhibin and ovarian steroid concentrations. 61
23978493 2013
46
The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. 61
24257556 2013
47
Granulosa cell tumor of the ovary with high FDG uptake. 61
23640219 2013
48
Ovarian granulosa cell tumors: a retrospective study of 27 cases and a review of the literature. 61
23777285 2013
49
[Granulosa cell tumor of the ovary - analysis of 15 cases in a single institution]. 61
23411956 2013
50
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report. 61
24051926 2013

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 GNAI2 NM_002070.4(GNAI2):c.535C>T (p.Arg179Cys)SNV Pathogenic 15903 rs137853226 3:50293694-50293694 3:50256262-50256262
2 GNAI2 NM_002070.4(GNAI2):c.536G>A (p.Arg179His)SNV Pathogenic 15904 rs137853227 3:50293695-50293695 3:50256263-50256263

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.17 INS ERBB2 ENO2
2 11.05 VIM TERT SERPINA1 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 SERPINA1 PRL INS INHA ENO2 CP

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 VIM TP53 INS ERBB2 ACTC1
2 cellular protein metabolic process GO:0044267 9.46 SERPINA1 PRL INS CP
3 replicative senescence GO:0090399 9.37 TP53 TERT
4 negative regulation of blood vessel diameter GO:0097756 9.32 INS CHGA
5 positive regulation of follicle-stimulating hormone secretion GO:0046881 8.96 INHA FOXL2
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.8 TP53 TERT PRL

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 TP53 SERPINA1 INS
2 identical protein binding GO:0042802 9.17 VIM TP53 TERT SYP SERPINA1 INS
3 chaperone binding GO:0051087 9.13 TP53 TERT CP

Sources for Granulosa Cell Tumor of the Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....