Graves' Disease

Categories: Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Graves' Disease

MalaCards integrated aliases for Graves' Disease:

Name: Graves' Disease 12 75 25 15
Graves Disease 12 53 25 37 29 55 44 17 72
Exophthalmic Goiter 12 53 25
Toxic Diffuse Goiter 25 72
Basedow's Disease 12 25
Grave's Disease 12 15
Basedow Disease 53 25
Autoimmune Hyperthyroidism 25
Toxic Multinodular Goiter 72
Graves' Hyperthyroidism 53
Parry Disease 53


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Disease Ontology 12 DOID:12361
KEGG 37 H00082
MeSH 44 D006111
NCIt 50 C3071
SNOMED-CT 68 38591003 55807009
ICD10 33 E05.0
UMLS 72 C0018213 C0154143 C0342122

Summaries for Graves' Disease

Genetics Home Reference : 25 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age. Excess thyroid hormones can cause a variety of signs and symptoms. These include nervousness or anxiety, extreme tiredness (fatigue), a rapid and irregular heartbeat, hand tremors, frequent bowel movements or diarrhea, increased sweating and difficulty tolerating hot conditions, trouble sleeping, and weight loss in spite of an increased appetite. Affected women may have menstrual irregularities, such as an unusually light menstrual flow and infrequent periods. Some people with Graves disease develop an enlargement of the thyroid called a goiter. Depending on its size, the enlarged thyroid can cause the neck to look swollen and may interfere with breathing and swallowing. Between 25 and 50 percent of people with Graves disease have eye abnormalities, which are known as Graves ophthalmopathy. These eye problems can include swelling and inflammation, redness, dryness, puffy eyelids, and a gritty sensation like having sand or dirt in the eyes. Some people develop bulging of the eyes caused by inflammation of tissues behind the eyeball and "pulling back" (retraction) of the eyelids. Rarely, affected individuals have more serious eye problems, such as pain, double vision, and pinching (compression) of the optic nerve connecting the eye and the brain, which can cause vision loss. A small percentage of people with Graves disease develop a skin abnormality called pretibial myxedema or Graves dermopathy. This abnormality causes the skin on the front of the lower legs and the tops of the feet to become thick, lumpy, and red. It is not usually painful.

MalaCards based summary : Graves' Disease, also known as graves disease, is related to graves disease 1 and myxedema. An important gene associated with Graves' Disease is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Autoimmune thyroid disease and Cytokine Signaling in Immune system. The drugs Methimazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include thyroid gland, thyroid and eye, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Disease Ontology : 12 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

NIH Rare Diseases : 53 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). It is caused by the immune system mistakenly attacking the thyroid gland, causing the gland to produce too much thyroid hormone. Graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. However, the disorder may occur at any age and can affect males as well. More common signs and symptoms of hyperthyroidism due to Graves' disease include irritability, a fast and irregular heartbeat, hand tremors, diarrhea, increased sweating, trouble sleeping, and weight loss. Some people develop abnormal enlargement of the thyroid gland (goiter). Women with Graves' disease may have irregular menstrual periods. In some cases, Graves' disease causes other problems such as Graves' dermopathy (a condition marked by red, swollen skin), various eye abnormalities (such as bulging eyes, vision problems, pain, or swelling), emotional or behavioral changes, heart-related complications, or bone problems (such as osteoporosis). Treatment for hyperthyroidism and its symptoms may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. Most people eventually develop hypothyroidism after treatment for hyperthryoidism; this is treated with a daily synthetic thyroid hormone pill. Graves' dermopathy may be treated with corticosteroids and/or compression wraps. Eye problems may not improve after thyroid treatment and may be treated separately with eyedrops, rituximab, or rarely, surgery or radiation therapy.

KEGG : 37
Graves disease is a common form of chronic autoimmune thyroid disease (AITD), and is characterized by overstimulation of the thyroid gland with agonistic anti-thyrotropin (TSH) receptor autoantibodies. This overstimulation leads to follicular hypertrophy and hyperplasia, causing thyroid enlargement, as well as increases in thyroid hormone production and the fraction of triiodothyronine (T3) relative to thyroxine (T4) in thyroid secretion. Thyroid autoimmune diseases are regarded as polygenic disorders resulting from the combination of a genetic predisposition in conjunction with an environmental trigger. Two main approaches have been employed to locate susceptibility loci for AITD, namely case control candidate gene studies and genome-wide linkage screens. Case control candidate gene studies have been employed to investigate numerous genes for association with AITD, but to date, only the human leucocyte region (HLA) on chromosome 6p21 and the cytotoxic T lymphocyte associated 4 (CTLA-4) gene on chromosome 2q33 have been consistently shown to be associated with disease.

Wikipedia : 75 Graves' disease, also known as toxic diffuse goiter, is an autoimmune disease that affects the thyroid.... more...

Related Diseases for Graves' Disease

Diseases in the Graves' Disease family:

Graves Disease 1 Graves Disease 2

Diseases related to Graves' Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 837)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 34.3 TSHR TPO TG SERPINA7 GRD1 DIO2
2 myxedema 33.4 TSHR TPO TG CTLA4
3 hyperthyroidism 33.2 TSHR TPO TG SERPINA7 LMOD1 CTLA4
4 goiter 32.2 TSHR TPO TG SERPINA7
5 multinodular goiter 32.0 TSHR TPO TG
6 hypothyroidism 31.9 TSHR TPO TG SERPINA7 DIO2 CTLA4
7 thyroiditis 31.8 TSHR TPO TG SERPINA7 PTPN22 CTLA4
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.8 TSHR TPO TG PTPN22 IFNG CTLA4
9 plummer's disease 31.8 TPO TG ICAM1
10 papillary carcinoma 31.8 TSHR TPO TG
11 nodular goiter 31.8 TSHR TPO TG ICAM1
12 myasthenia gravis 31.7 IL4 IFNG CTLA4
13 thyroid gland disease 31.6 TSHR TPO TG SERPINA7 DIO2
14 struma ovarii 31.6 TSHR TG
15 subacute thyroiditis 31.5 TSHR TPO TG SERPINA7
16 follicular adenoma 31.3 TSHR TPO TG
17 differentiated thyroid carcinoma 31.3 TSHR TPO TG
18 autoimmune disease 31.2 TPO TG PTPN22 IL4 IL2RA IFNG
19 hashimoto encephalopathy 31.2 TSHR TPO
20 celiac disease 1 31.1 TPO TG PTPN22 HLA-DQA1 CTLA4
21 hypoadrenocorticism, familial 31.1 TPO PTPN22 CTLA4
22 postsurgical hypothyroidism 31.1 TSHR TG
23 hyperthyroxinemia 31.0 TSHR TPO SERPINA7
24 nontoxic goiter 31.0 TSHR TPO TG SERPINA7
25 benign struma ovarii 31.0 TSHR TG
26 congenital hypothyroidism 30.9 TSHR TPO TG SERPINA7
27 diabetes mellitus 30.8 PTPN22 IL2RA IFNG HLA-DQA1 CTLA4
28 thyroid cancer, nonmedullary, 2 30.8 TSHR TPO TG LMOD1 DIO2
29 uveitis 30.8 IL4 IL2RA IFNG ICAM1 CTLA4
30 bone inflammation disease 30.7 PTPN22 IL4 IFNG
31 idiopathic interstitial pneumonia 30.7 IL4 IFNG ICAM1
32 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.7 TPO TG
33 vogt-koyanagi-harada disease 30.6 PTPN22 IL2RA HLA-DQA1
34 conjunctivitis 30.6 IL4 IFNG ICAM1
35 immune deficiency disease 30.5 IL4 IL2RA CD40
36 diabetes mellitus, insulin-dependent 30.5 TPO TG PTPN22 IL4 IL2RA IFNG
37 hashimoto thyroiditis 30.5 TSHR TPO TG PTPN22 IL4 IL2RA
38 orbital plasma cell granuloma 30.5 TSHR CTLA4
39 endemic goiter 30.5 TSHR TPO TG SERPINA7
40 tetanus 30.5 IL4 IL2RA IFNG
41 toxic diffuse goiter 30.4 TSHR TPO TG SERPINA7 DIO2
42 scleritis 30.4 IL4 IFNG
43 acute graft versus host disease 30.4 IL4 IL2RA IFNG
44 hypothyroidism, congenital, nongoitrous, 2 30.3 TSHR TG SERPINA7
45 keratoconjunctivitis 30.3 IL4 IFNG ICAM1
46 alopecia areata 30.3 PTPN22 IL2RA IFNG ICAM1 CTLA4
47 pulmonary sarcoidosis 30.3 IL2RA IFNG ICAM1
48 relapsing-remitting multiple sclerosis 30.2 IL4 IFNG ICAM1
49 allergic asthma 30.2 IL4 IL16 IFNG
50 proteasome-associated autoinflammatory syndrome 1 30.2 IL4 IFNG ICAM1

Graphical network of the top 20 diseases related to Graves' Disease:

Diseases related to Graves' Disease

Symptoms & Phenotypes for Graves' Disease

MGI Mouse Phenotypes related to Graves' Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.07 CD40 CTLA4 DIO2 HLA-DQA1 ICAM1 IFNG
2 hematopoietic system MP:0005397 9.97 CD40 CTLA4 HLA-DQA1 ICAM1 IFNG IL16
3 digestive/alimentary MP:0005381 9.92 CTLA4 DIO2 ICAM1 IFNG IL2RA IL4
4 homeostasis/metabolism MP:0005376 9.73 CD40 CTLA4 DIO2 ICAM1 IFNG IL2RA
5 immune system MP:0005387 9.44 CD40 CTLA4 HLA-DQA1 ICAM1 IFNG IL16

Drugs & Therapeutics for Graves' Disease

Drugs for Graves' Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 159)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Methimazole Approved Phase 4 60-56-0 1349907
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Propranolol Approved, Investigational Phase 4 525-66-6 4946
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
rituximab Approved Phase 4 174722-31-7 10201696
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
leucovorin Approved Phase 4 58-05-9 143 6006
Iodine Approved, Investigational Phase 4 7553-56-2 807
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
15 Anti-Infective Agents, Local Phase 4
16 Anti-Infective Agents Phase 4
17 HIV Protease Inhibitors Phase 4
protease inhibitors Phase 4
19 BB 1101 Phase 4
20 Vasodilator Agents Phase 4
21 Liver Extracts Phase 4
22 Analgesics Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Analgesics, Non-Narcotic Phase 4
25 Adrenergic beta-1 Receptor Antagonists Phase 4
26 Anti-Inflammatory Agents, Non-Steroidal Phase 4
27 Sympatholytics Phase 4
28 Lubricant Eye Drops Phase 4
29 Oxytocics Phase 4
30 Benzalkonium Compounds Phase 4
31 Antibodies Phase 4
32 Immunologic Factors Phase 4
33 Immunoglobulins Phase 4
34 Antineoplastic Agents, Immunological Phase 4
35 Antirheumatic Agents Phase 4
36 Folic Acid Antagonists Phase 4
37 Nucleic Acid Synthesis Inhibitors Phase 4
38 Vitamin B9 Phase 4
39 Immunosuppressive Agents Phase 4
40 Folate Phase 4
41 Vitamin B Complex Phase 4
42 Dermatologic Agents Phase 4
43 Antimetabolites, Antineoplastic Phase 4
44 cadexomer iodine Phase 4
45 Coagulants Phase 4
46 Pharmaceutical Solutions Phase 4
47 Lugol's solution Phase 4
Propylthiouracil Approved, Investigational Phase 3 51-52-5 657298
Carbimazole Approved, Investigational Phase 3 22232-54-8 31072
tannic acid Approved Phase 3 1401-55-4

Interventional clinical trials:

(show top 50) (show all 109)
# Name Status NCT ID Phase Drugs
1 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
2 Prevention Relapse of Graves' Disease by Treatment With Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
3 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
4 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
5 Influence of Methylprednisolone Pulse Therapy on Liver Function in Patients With Graves' Orbitopathy Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
6 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
7 Prostaglandin F2-alpha Eye Drops (Bimatoprost) in Thyroid Eye Disease: a Randomised Controlled Double Blind Crossover Trial Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
8 Rituximab (RTX) Therapy in Steroid Resistant Patients or Patients Relapsing After Intravenous Steroids With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
9 Randomized Clinical Trial, Blinded for the Researcher and Multicenter, to Evaluate the Efficacy and Safety of Preoperative Preparation With Lugol Solution in Euthyroid Patients With Graves-Basedow Disease. Not yet recruiting NCT03980132 Phase 4 Lugols Strong Iodine
10 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Not yet recruiting NCT03969108 Phase 4 Indocyanine Green
11 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
12 Prevention of Overt Hypothyroidism Following Radioactive Iodine Therapy for Graves' Disease Unknown status NCT01950260 Phase 2, Phase 3 Levothyroxine
13 Prospective Randomized Clinical Trial of Total Thyroidectomy (Tx) Versus Thionamides (Anti-Thyroid Drugs) in Patients With Moderate-to-Severe Graves' Ophthalmopathy - a 1-year Follow-up Unknown status NCT03066076 Phase 3 Antithyroid Drug
14 "5010 Clinical Research Programme"of Sun Yat-sen University Unknown status NCT01204359 Phase 3
15 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism: A Clinical Trial With Historical Control Completed NCT01039818 Phase 3
16 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
17 A Randomised Study of Two Anti-thyroid Drug Treatment Regimens in Young People Completed NCT01436994 Phase 3 carbimazole;propylthiouracil;thyroxine
18 Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg
19 A Multi-center, Open Label, Randomised Parallel- Group Study to Compare the Efficacy of Cholestyramine Plus Standard Treatment Versus Prednisolone Plus Standard Treatment Versus Standard Treatment Alone in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
20 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
21 Investigation of Novel Biomarkers and Definition of the Role of the Microbiome In Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
22 The Effect of Subantimicrobial Dose Doxycycline in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
23 An Open Label Study to Evaluate the Safety and Efficacy of 12 Week Treatment With CFZ533 in Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533
24 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos
25 Rituximab Treatment of Graves' Dysthyroid Ophthalmopathy Phase I/II Completed NCT00424151 Phase 1, Phase 2 Rituximab
26 Pretreatment With Recombinant Human Thyrotropin (rhTSH) for the Effect on Thyroid Size and Function, and for the Effect of Radioiodine Treatment in Patients With Nodular Goiter. Prospective, Randomized Double-blinded Trials. Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
27 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy: a Prospective, Uncontrolled Pilot Study Completed NCT01727973 Phase 1, Phase 2 Doxycycline
28 Radioactive Iodide Therapy for Pediatric Graves' Disease Completed NCT01269749 Phase 2 ATD Group
29 Thyroid Hormone to Induce Non-Insulin Mediated Glucose Disposal in Patients With Insulin Receptor Mutations Completed NCT02457897 Phase 2 Liothyronine
30 A Pilot Study of Immune Checkpoint Inhibition (Durvalumab With or Without Tremelimumab) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer Recruiting NCT02311361 Phase 1, Phase 2
31 A Phase II, Open-labeled, Ophthalmological External Investigator-blinded, Single-center, Randomized, Superiority, Non Profit, Pilot Clinical Trial to Evaluate the Effects of Atorvastatin on Graves' Orbitopathy (GO) in Hypercholesterolemic Patients With Moderate-to-severe and Active GO Subjected to Intravenous Glucocorticoid Therapy: the STAGO Study Not yet recruiting NCT03110848 Phase 2 Atorvastatin;Methylprednisolone
32 Pilot Study of Teriparatide for Postsurgical Hypoparathyroidism Terminated NCT01171690 Phase 2 Teriparatide
33 Safety and Proof of Principle Study of ATX-GD-59 in Male and Female Subjects With Graves' Disease Not Currently Treated With Anti-thyroid Therapy: An Open Label Study, With an Upward Titration Over Five Dose Levels Administered by Intradermal Injection Completed NCT02973802 Phase 1
34 Function of Regulatory T Cells Improved by Treatment With an Intrathyroid Injection of Dexamethasone in Graves' Patients Completed NCT01534169 Phase 1 Dexamethasone
35 K1-70 - A Phase I, Single Ascending Intramuscular Dose or Single Ascending Intravenous Dose, Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in Subjects With Graves' Disease Recruiting NCT02904330 Phase 1 K1-70 intramuscular or K1-70 intravenous
36 GRAves Selenium Supplementation Trial (GRASS) - an Investigator-initiated Randomised, Blinded, Multicentre Clinical Trial of Selenium Supplementation Versus Placebo in Patients With Graves' Hyperthyroidism Unknown status NCT01611896
37 The Effect of Different Calculated Doses of I-131 in Treatment of Patients With Grave's Disease Unknown status NCT02114619 Low dose of I-131;Intermediate dose;High dose
38 Comparison of Standardized Update Value Using Single-photo Emission Computed Tomography and Computed Tomography Between Grave's Disease (Hyperthyroidism) Patients and Normal Humans Unknown status NCT02772705
39 Application of Digital Infrared Thermal Imaging in Thyroid Disease and Associated Ophthalmopathy and Dermopathy Unknown status NCT01182584
40 The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan Unknown status NCT01260532
41 Study of DNA Methylation in Children and Adolescents With Autoimmune Thyroid Diseases Unknown status NCT02491567
42 Shared Decision Making in Graves Disease - Graves Disease (GD) Choice Completed NCT02107794
43 Randomized Open Clinical Study to Evaluate the Efficacy of Selenium Plus Methimazole for Treatment of Graves' Hyperthyroidism Completed NCT02727738 Methimazole
44 Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study Completed NCT02798965
45 A Prospective Evaluation of High Intensity Focused Ultrasound (HIFU) in the Treatment of Relapsed Graves' Disease Completed NCT02685514
46 Serum Antibodies Against the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Graves' Disease and Graves' Orbitopathy Completed NCT03498417
47 Low Doses of Cholestyramine in the Treatment of Hyperthyroidism Completed NCT00677469 Cholestyramine;Cholestyramine;Placebo powder
49 Prospective Randomized Study of Therapy Withdrawal vs Continued Low Dose Medical Therapy in Patients With Graves' Disease Entering Remission During ATD Therapy Completed NCT00796913
50 Evaluation of Optimal Time of Methimazole Discontinuation Before Radio-iodine Therapy in Hyperthyroid Grave's Patients Completed NCT01560299 Methimazole;Methimazole;Methimazole

Search NIH Clinical Center for Graves' Disease

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Cochrane evidence based reviews: graves disease

Genetic Tests for Graves' Disease

Genetic tests related to Graves' Disease:

# Genetic test Affiliating Genes
1 Graves Disease 29

Anatomical Context for Graves' Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Graves' Disease:

Thyroid Gland

MalaCards organs/tissues related to Graves' Disease:

Thyroid, Eye, T Cells, Bone, Testes, Heart, Skin

Publications for Graves' Disease

Articles related to Graves' Disease:

(show top 50) (show all 11101)
# Title Authors PMID Year
Gene polymorphisms of interleukin-4, interleukin-10 and transforming growth factor-beta in Graves' disease. 9 38
19882211 2010
Immunopathogenesis of thyroid eye disease: emerging paradigms. 9 38
20385333 2010
HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease. 9 38
20300120 2010
Four patients with hypothyroid Graves' disease. 9 38
20421660 2010
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 9 38
20464711 2010
Association of the CTLA4 gene with Graves' disease in the Chinese Han population. 9 38
20352109 2010
Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease. 9 38
19438904 2010
Resistance to thyroid hormone in a patient with coexisting Graves' disease. 9 38
20151830 2010
A long-term follow-up of serum myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease treated with propylthiouracil. 9 38
19851036 2010
The level of TSH appeared favourable in maintaining bone mineral density in postmenopausal women. 9 38
20151763 2010
Type 1 diabetes and autoimmune polyglandular syndrome: a clinical review. 9 38
20009114 2009
TSH receptor autoantibodies. 9 38
19332151 2009
[New assays of TSH-receptor antibodies: analytical and clinical performances in the diagnosis of Graves' disease]. 9 38
19939769 2009
49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease. 9 38
19559744 2009
Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity. 9 38
19669106 2009
Association of polymorphism at position 49 in exon 1 of the cytotoxic T-lymphocyte-associated factor 4 gene with Graves' disease refractory to medical treatment, but not with amiodarone-associated thyroid dysfunction. 9 38
19731979 2009
Autoimmune thyroid disease: unlocking a complex puzzle. 9 38
19474733 2009
Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease. 9 38
19684474 2009
Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients. 9 38
19524188 2009
The T393C polymorphism of the Galphas gene (GNAS1) is associated with the course of Graves' disease. 9 38
19513951 2009
Vitamin D receptor (VDR) gene polymorphisms and Graves' disease: a meta-analysis. 9 38
18782354 2009
Monokine induced by interferon gamma (IFNgamma) (CXCL9) and IFNgamma inducible T-cell alpha-chemoattractant (CXCL11) involvement in Graves' disease and ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists. 9 38
19276231 2009
The relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases. 9 38
19250272 2009
Cytotoxic T lymphocyte-associated molecule-4 polymorphism in Turkish patients with Hashimoto thyroiditis. 9 38
19284444 2009
Membranous nephropathy associated with thyroid-peroxidase antigen. 9 38
18762990 2009
[Thyroid-stimulating hormone receptor antibodies in the diagnosis of Graves' disease in children]. 9 38
19388481 2009
Polymorphisms in the ADRB2 gene and Graves disease: a case-control study and a meta-analysis of available evidence. 9 38
19284637 2009
Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. 9 38
19050049 2009
An investigation of the C77G and C772T variations within the human protein tyrosine phosphatase receptor type C gene for association with multiple sclerosis in an Australian population. 9 38
19111528 2009
Graves' disease occurring after surgery of a multinodular goiter: a case report. 9 38
18563680 2009
First automated assay for thyrotropin receptor autoantibodies. 9 38
19634982 2009
Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. 9 38
19116909 2009
Association of CD40 and thyroglobulin genes with later-onset Graves' disease in Taiwanese patients. 9 38
18755875 2008
No association between Fas A/G polymorphism and therapeutic effects induced by methimazole treatment for Graves' disease in Northern Chinese. 9 38
18972838 2008
Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. 9 38
18768899 2008
CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid diseases. 9 38
18752454 2008
Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children. 9 38
18780601 2008
Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease. 9 38
18394967 2008
Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population. 9 38
18578611 2008
Association of CTLA-4 and IL-13 gene polymorphisms with Graves' disease and ophthalmopathy in Chinese children. 9 38
18296657 2008
Differential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditis. 9 38
18505906 2008
PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging. 9 38
18312479 2008
Thyrotoxicosis factitia masquerading as recurrent Graves' disease: endogenous antibody immunoassay interference, a pitfall for the unwary. 9 38
18482926 2008
Thyroglobulin mRNA expression in peripheral blood lymphocytes of healthy subjects and patients with thyroid disease. 9 38
18243140 2008
An alternative therapy for graves' disease: clinical effects and mechanisms of an herbal remedy. 9 38
18379045 2008
Enhancement of experimental Graves' disease by intranasal administration of a T cell epitope of the thyrotropin receptor. 9 38
18234558 2008
The functional R620W variant of the PTPN22 gene is associated with celiac disease. 9 38
18194365 2008
Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it. 9 38
18385936 2008
Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan. 9 38
18059468 2008
Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland. 9 38
17942509 2008

Variations for Graves' Disease

Expression for Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for Graves' Disease

Pathways related to Graves' Disease according to KEGG:

# Name Kegg Source Accession
1 Autoimmune thyroid disease hsa05320

Pathways related to Graves' Disease according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
5 12.23 IL2RA ICAM1 HLA-DQA1 CD40
Show member pathways
Show member pathways
12.09 IL4 IFNG HLA-DQA1 CD40
Show member pathways
9 11.87 IL4 IFNG ICAM1
Show member pathways
11 11.87 ICAM1 HLA-DQA1 CTLA4 CD40
12 11.85 IL4 IL2RA IFNG
Show member pathways
11.83 IL4 IL2RA IFNG
14 11.76 IL4 IL2RA HLA-DQA1
15 11.67 IL4 IFNG ICAM1
16 11.65 IL4 IL2RA IFNG
18 11.57 IL4 IFNG CD40
19 11.56 PTPN22 HLA-DQA1 CTLA4
Show member pathways
21 11.34 IFNG ICAM1 CD40
22 11.27 IL4 IL2RA IFNG
23 10.78 IL4 IL2RA IFNG CD40
24 10.11 TSHR TPO TG

GO Terms for Graves' Disease

Cellular components related to Graves' Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.1 TSHR TPO IL2RA ICAM1 FCRL3 CD40

Biological processes related to Graves' Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.92 PTPN22 IL2RA HLA-DQA1 CTLA4 CD40
2 cytokine-mediated signaling pathway GO:0019221 9.81 IL4 IL2RA IL16 ICAM1
3 positive regulation of cold-induced thermogenesis GO:0120162 9.67 TSHR IL4 DIO2
4 immune response GO:0006955 9.63 IL4 IL2RA IL16 IFNG HLA-DQA1 CTLA4
5 positive regulation of T cell differentiation GO:0045582 9.55 IL4 IL2RA
6 regulation of NIK/NF-kappaB signaling GO:1901222 9.54 UACA PTPN22
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IL4 IFNG CD40
8 interferon-gamma-mediated signaling pathway GO:0060333 9.5 IFNG ICAM1 HLA-DQA1
9 negative regulation of immune response GO:0050777 9.48 IL2RA CTLA4
10 thyroid hormone generation GO:0006590 9.46 TPO DIO2
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IL4 CD40
12 positive regulation of B cell proliferation GO:0030890 9.43 IL4 FCRL3 CD40
13 thyroid hormone metabolic process GO:0042403 9.4 TG DIO2
14 regulation of regulatory T cell differentiation GO:0045589 9.13 IL2RA IFNG CTLA4
15 hormone biosynthetic process GO:0042446 8.8 TPO TG DIO2

Sources for Graves' Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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