MCID: GRV012
MIFTS: 34

Grover's Disease

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Grover's Disease

MalaCards integrated aliases for Grover's Disease:

Name: Grover's Disease 54 74
Persistent Acantholytic Dermatosis 54
Transient Acantholytic Dermatosis 54
Grover Disease 54
Tad 54

Classifications:



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ICD10 34 L11.1
UMLS 74 C0263325

Summaries for Grover's Disease

NIH Rare Diseases : 54 Grover's disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months. Occasionally, this condition may persist for longer periods, or it may come and go over time. The exact cause is unknown; however, a number of factors may cause or worsen the condition including heat and sweating. While there is no cure for Grover's disease, there may be ways to manage the condition, such as avoidance of factors that worsen symptoms, moisturizers, and topical corticosteroids.

MalaCards based summary : Grover's Disease, also known as persistent acantholytic dermatosis, is related to pemphigus and pemphigus vulgaris. An important gene associated with Grover's Disease is DSP (Desmoplakin), and among its related pathways/superpathways are Developmental Biology and PAK Pathway. Affiliated tissues include skin, bone and kidney.

Wikipedia : 77 Grover''s disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized... more...

Related Diseases for Grover's Disease

Diseases related to Grover's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 pemphigus 29.8 DSP JUP
2 pemphigus vulgaris 29.7 DSP JUP
3 follicular lymphoma 10.2
4 lymphoma 10.2
5 leukemia 10.1
6 myelodysplastic syndrome 10.1
7 hairy cell leukemia 10.1
8 pyoderma 10.1
9 pyoderma gangrenosum 10.1
10 pityriasis versicolor 10.1
11 pemphigus erythematosus 10.1
12 epidermolytic hyperkeratosis 10.1
13 bullous pemphigoid 10.1
14 epidermolysis bullosa, lethal acantholytic 10.0 DSP JUP
15 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.0 DSP JUP
16 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.0 DSP JUP
17 ige responsiveness, atopic 10.0
18 pemphigus vulgaris, familial 10.0
19 scleroderma, familial progressive 10.0
20 chronic kidney failure 10.0
21 melanoma 10.0
22 syringoma 10.0
23 herpes simplex 10.0
24 rosacea 10.0
25 skin melanoma 10.0
26 macroglobulinemia 10.0
27 demodicidosis 10.0
28 granulomatous rosacea 10.0
29 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.0 DSP JUP
30 palmoplantar keratoderma and woolly hair 10.0 DSP JUP
31 arrhythmogenic right ventricular dysplasia, familial, 1 10.0 DSP JUP
32 naxos disease 10.0 DSP JUP
33 ectodermal dysplasia/skin fragility syndrome 10.0 DSP JUP
34 arrhythmogenic right ventricular dysplasia, familial, 9 9.9 DSP JUP
35 arrhythmogenic right ventricular dysplasia, familial, 8 9.9 DSP JUP
36 piebald trait 9.9
37 leukemia, acute myeloid 9.9
38 basal cell carcinoma 1 9.9
39 membranous nephropathy 9.9
40 glomerulonephritis 9.9
41 pemphigus foliaceus 9.9
42 basal cell carcinoma 9.9
43 porokeratosis 9.9
44 myeloid leukemia 9.9
45 benign chronic pemphigus 9.9 DSP JUP
46 cardiomyopathy, dilated, with woolly hair and keratoderma 9.9 DSP JUP
47 palmoplantar keratosis 9.9 DSP JUP
48 intrinsic cardiomyopathy 9.9 DSP JUP
49 atrial standstill 1 9.8 DSP JUP
50 left ventricular noncompaction 9.7 DSP JUP

Graphical network of the top 20 diseases related to Grover's Disease:



Diseases related to Grover's Disease

Symptoms & Phenotypes for Grover's Disease

Drugs & Therapeutics for Grover's Disease

Search Clinical Trials , NIH Clinical Center for Grover's Disease

Genetic Tests for Grover's Disease

Anatomical Context for Grover's Disease

MalaCards organs/tissues related to Grover's Disease:

42
Skin, Bone, Kidney, Bone Marrow, Liver, Heart, Neutrophil

Publications for Grover's Disease

Articles related to Grover's Disease:

(show top 50) (show all 74)
# Title Authors Year
1
Grover’s Disease Treated With Total Skin Electron Beam Radiotherapy ( 31013013 )
2019
2
Erratum to: A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. ( 28116090 )
2017
3
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
4
Grover's disease: dermoscopy, reflectance confocal microscopy and histopathological correlation. ( 29085721 )
2017
5
Dermoscopic characteristics of transient acantholytic dermatosis (Grover's disease). ( 29171389 )
2017
6
Monolateral Grover's Disease with Blaschkoid Distribution. ( 30064609 )
2017
7
Dermoscopy of Grover's disease: Variability according to histological subtype. ( 26892381 )
2016
8
Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation. ( 27358215 )
2016
9
A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. ( 27660709 )
2016
10
Grover's disease in chronic kidney failure. ( 26299177 )
2015
11
Pruritic Papules Following Lumbar Corset Use: A Quiz. Grover's disease. ( 25708298 )
2015
12
Grover's disease and cutaneous melanoma: a fortuitous association or a paraneoplastic case? ( 26159656 )
2015
13
Grover's Disease in a Liver Transplant Patient. ( 24648700 )
2014
14
Grover's Disease with Acrosyringeal Acantholysis: A Rare Histological Presentation of an Uncommon Disease. ( 25484405 )
2014
15
Grover's disease secondarily infected with herpes simplex virus and Staphylococcus aureus: case report and review. ( 23013197 )
2013
16
Transient acantholytic dermatosis (Grover's disease) with an isolated eruption. ( 23783409 )
2013
17
Grover's disease in a peritoneal dialysis patient. ( 23897199 )
2013
18
Is Grover's disease an autoimmune dermatosis? ( 24131368 )
2013
19
Grover's disease in a renal transplant patient, after hemodialysis renewal. ( 22481593 )
2012
20
Grover's disease following multiple bilateral Blaschko lines: a rare clinical presentation with genetic and electron microscopic analyses. ( 23075809 )
2012
21
Dermatoscopy of Grover's disease and solitary acantholytic dyskeratoma shows a brown, star-like pattern. ( 23157785 )
2012
22
Grover's Disease after Heart Transplantation: A Case Report. ( 23320241 )
2012
23
Leukemia cutis in association With Grover's disease. ( 21242761 )
2011
24
Grover's disease and mercury. ( 19827971 )
2010
25
Grover's disease associated with pregnancy. ( 20507412 )
2010
26
Paraneoplastic transient acantholytic dermatosis (Grover's disease) along Blaschko lines. ( 19467976 )
2009
27
Grover's Disease after Bone Marrow Transplantation. ( 17697974 )
2007
28
Clinicopathological spectrum of chemotherapy induced Grover's disease. ( 17714163 )
2007
29
Grover's disease in a patient undergoing peritoneal dialysis with resolution after renal transplant. ( 17989906 )
2007
30
Transient acantholytic dermatosis (Grover's disease) in a renal transplant patient. ( 16620222 )
2006
31
A case of Grover's disease with syringoma-like features and leukemia cutis. ( 16776721 )
2006
32
Grover's disease induced by cetuximab. ( 16778425 )
2006
33
Seasonal variation of transient acantholytic dyskeratosis (Grover's disease). ( 16844509 )
2006
34
Effective treatment of persistent Grover's disease with trichloroacetic acid peeling. ( 16918573 )
2006
35
Pruritic papules on the chest and back. Grover's disease. ( 16939188 )
2006
36
Medium-dose ultraviolet A1 phototherapy in transient acantholytic dermatosis (Grover's disease). ( 15627107 )
2005
37
Grover's disease (transient acantholytic dermatosis) associated with atopy. ( 15857481 )
2005
38
Persistent acantholytic dermatosis and extensive lentiginous 'freckling': a new entity? ( 16029360 )
2005
39
Grover's disease: 34 years on. ( 15068451 )
2004
40
Grover's disease: successful treatment with acitretin and calcipotriol. ( 15506319 )
2004
41
Kaposi's varicelliform eruption in a patient with Grover's disease. ( 14576678 )
2003
42
Linear Darier's or Grover's disease? ( 14639427 )
2003
43
Persistent acantholytic dermatosis of the lip related to solar damage. ( 12539033 )
2003
44
Treatment of Grover's disease with tacalcitol. ( 11952712 )
2002
45
Unilateral transient acantholytic dermatosis (Grover's disease) along Blaschko lines. ( 12140485 )
2002
46
Grover's disease associated with Sarcoptes scabiei. ( 11385234 )
2001
47
Grover's disease secondary to ribavirin. ( 10848771 )
2000
48
Grover's disease associated with Waldenström's macroglobulinemia and neutrophilic dermatosis. ( 10877140 )
2000
49
Grover's disease, despite histological similarity to Darier's disease, does not share an abnormality in the ATP2A2 gene. ( 10971355 )
2000
50
A case report: persistent acantholytic dermatosis in chronic renal failure. ( 11269988 )
2000

Variations for Grover's Disease

Expression for Grover's Disease

Search GEO for disease gene expression data for Grover's Disease.

Pathways for Grover's Disease

GO Terms for Grover's Disease

Cellular components related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 DSP EGF JUP VCL
2 cell junction GO:0030054 9.67 DSP JUP VCL
3 actin cytoskeleton GO:0015629 9.54 JUP VCL
4 intermediate filament GO:0005882 9.52 DSP JUP
5 ficolin-1-rich granule lumen GO:1904813 9.51 JUP VCL
6 cell-cell adherens junction GO:0005913 9.48 JUP VCL
7 adherens junction GO:0005912 9.46 JUP VCL
8 cornified envelope GO:0001533 9.4 DSP JUP
9 specific granule lumen GO:0035580 9.37 JUP VCL
10 cell-cell junction GO:0005911 9.33 DSP JUP VCL
11 intercalated disc GO:0014704 9.32 DSP JUP
12 desmosome GO:0030057 9.26 DSP JUP
13 zonula adherens GO:0005915 8.96 JUP VCL
14 fascia adherens GO:0005916 8.8 DSP JUP VCL

Biological processes related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.54 DSP JUP VCL
2 keratinization GO:0031424 9.49 DSP JUP
3 cell-cell adhesion GO:0098609 9.48 DSP JUP
4 platelet degranulation GO:0002576 9.46 EGF VCL
5 cornification GO:0070268 9.43 DSP JUP
6 positive regulation of canonical Wnt signaling pathway GO:0090263 9.4 EGF JUP
7 skin development GO:0043588 9.32 DSP JUP
8 adherens junction organization GO:0034332 9.26 DSP JUP
9 regulation of heart rate by cardiac conduction GO:0086091 9.16 DSP JUP
10 regulation of ventricular cardiac muscle cell action potential GO:0098911 8.96 DSP JUP
11 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 8.62 DSP JUP

Molecular functions related to Grover's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 DSP JUP VCL
2 cell adhesion molecule binding GO:0050839 9.26 DSP JUP
3 alpha-catenin binding GO:0045294 8.96 JUP VCL
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 DSP JUP

Sources for Grover's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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