TAD
MCID: GRV012
MIFTS: 34

Grover's Disease (TAD)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Grover's Disease

MalaCards integrated aliases for Grover's Disease:

Name: Grover's Disease 53 73
Persistent Acantholytic Dermatosis 53
Transient Acantholytic Dermatosis 53
Grover Disease 53
Tad 53

Classifications:



External Ids:

ICD10 33 L11.1
UMLS 73 C0263325

Summaries for Grover's Disease

NIH Rare Diseases : 53 Grover's disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months. Occasionally, this condition may persist for longer periods, or it may come and go over time. The exact cause is unknown; however, a number of factors may cause or worsen the condition including heat and sweating. While there is no cure for Grover's disease, there may be ways to manage the condition, such as avoidance of factors that worsen symptoms, moisturizers, and topical corticosteroids.

MalaCards based summary : Grover's Disease, also known as persistent acantholytic dermatosis, is related to pemphigus and follicular lymphoma. An important gene associated with Grover's Disease is DSP (Desmoplakin), and among its related pathways/superpathways are Developmental Biology and PAK Pathway. Affiliated tissues include skin, bone and bone marrow.

Wikipedia : 76 Grover''s disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized... more...

Related Diseases for Grover's Disease

Diseases related to Grover's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 pemphigus 30.4 DSP JUP
2 follicular lymphoma 10.2
3 pemphigus foliaceus 10.2
4 lymphoma 10.2
5 ige responsiveness, atopic 10.1
6 scleroderma, familial progressive 10.1
7 myelodysplastic syndrome 10.1
8 hairy cell leukemia 10.1
9 pyoderma 10.1
10 pyoderma gangrenosum 10.1
11 rosacea 10.1
12 pityriasis versicolor 10.1
13 demodicidosis 10.1
14 granulomatous rosacea 10.1
15 pemphigus erythematosus 10.1
16 epidermolytic hyperkeratosis 10.0
17 bullous pemphigoid 10.0
18 epidermolysis bullosa, lethal acantholytic 10.0 DSP JUP
19 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.0 DSP JUP
20 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.0 DSP JUP
21 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.0 DSP JUP
22 palmoplantar keratoderma and woolly hair 10.0 DSP JUP
23 arrhythmogenic right ventricular dysplasia, familial, 1 10.0 DSP JUP
24 naxos disease 10.0 DSP JUP
25 ectodermal dysplasia/skin fragility syndrome 10.0 DSP JUP
26 arrhythmogenic right ventricular dysplasia, familial, 9 10.0 DSP JUP
27 arrhythmogenic right ventricular dysplasia, familial, 8 10.0 DSP JUP
28 benign chronic pemphigus 10.0 DSP JUP
29 cardiomyopathy, dilated, with woolly hair and keratoderma 9.9 DSP JUP
30 palmoplantar keratosis 9.9 DSP JUP
31 intrinsic cardiomyopathy 9.9 DSP JUP
32 pemphigus vulgaris 9.9 DSP JUP
33 leukemia, acute myeloid 9.9
34 glomerulonephritis 9.9
35 leukemia 9.9
36 porokeratosis 9.9
37 myeloid leukemia 9.9
38 atrial standstill 1 9.9 DSP JUP
39 left ventricular noncompaction 9.8 DSP JUP
40 darier-white disease 9.8 DSP JUP VCL
41 arrhythmogenic right ventricular cardiomyopathy 9.8 DSP JUP VCL
42 hypertrophic cardiomyopathy 9.8 DSP VCL
43 dilated cardiomyopathy 9.7 DSP JUP VCL

Graphical network of the top 20 diseases related to Grover's Disease:



Diseases related to Grover's Disease

Symptoms & Phenotypes for Grover's Disease

Drugs & Therapeutics for Grover's Disease

Search Clinical Trials , NIH Clinical Center for Grover's Disease

Genetic Tests for Grover's Disease

Anatomical Context for Grover's Disease

MalaCards organs/tissues related to Grover's Disease:

41
Skin, Bone, Bone Marrow, Kidney, Liver, Heart, Myeloid

Publications for Grover's Disease

Articles related to Grover's Disease:

(show top 50) (show all 71)
# Title Authors Year
1
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
2
Grover's disease: dermoscopy, reflectance confocal microscopy and histopathological correlation. ( 29085721 )
2017
3
Dermoscopic characteristics of transient acantholytic dermatosis (Grover's disease). ( 29171389 )
2017
4
Erratum to: A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. ( 28116090 )
2017
5
Monolateral Grover's Disease with Blaschkoid Distribution. ( 30064609 )
2017
6
Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation. ( 27358215 )
2016
7
A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. ( 27660709 )
2016
8
Dermoscopy of Grover's disease: Variability according to histological subtype. ( 26892381 )
2016
9
Grover's disease and cutaneous melanoma: a fortuitous association or a paraneoplastic case? ( 26159656 )
2015
10
Grover's disease in chronic kidney failure. ( 26299177 )
2015
11
Pruritic Papules Following Lumbar Corset Use: A Quiz. Grover's disease. ( 25708298 )
2015
12
Grover's Disease in a Liver Transplant Patient. ( 24648700 )
2014
13
Grover's Disease with Acrosyringeal Acantholysis: A Rare Histological Presentation of an Uncommon Disease. ( 25484405 )
2014
14
Transient acantholytic dermatosis (Grover's disease) with an isolated eruption. ( 23783409 )
2013
15
Grover's disease in a peritoneal dialysis patient. ( 23897199 )
2013
16
Grover's disease secondarily infected with herpes simplex virus and Staphylococcus aureus: case report and review. ( 23013197 )
2013
17
Is Grover's disease an autoimmune dermatosis? ( 24131368 )
2013
18
Grover's disease in a renal transplant patient, after hemodialysis renewal. ( 22481593 )
2012
19
Grover's Disease after Heart Transplantation: A Case Report. ( 23320241 )
2012
20
Grover's disease following multiple bilateral Blaschko lines: a rare clinical presentation with genetic and electron microscopic analyses. ( 23075809 )
2012
21
Dermatoscopy of Grover's disease and solitary acantholytic dyskeratoma shows a brown, star-like pattern. ( 23157785 )
2012
22
Leukemia cutis in association With Grover's disease. ( 21242761 )
2011
23
Grover's disease and mercury. ( 19827971 )
2010
24
Grover's disease associated with pregnancy. ( 20507412 )
2010
25
Paraneoplastic transient acantholytic dermatosis (Grover's disease) along Blaschko lines. ( 19467976 )
2009
26
Grover's Disease after Bone Marrow Transplantation. ( 17697974 )
2007
27
Clinicopathological spectrum of chemotherapy induced Grover's disease. ( 17714163 )
2007
28
Grover's disease in a patient undergoing peritoneal dialysis with resolution after renal transplant. ( 17989906 )
2007
29
A case of Grover's disease with syringoma-like features and leukemia cutis. ( 16776721 )
2006
30
Grover's disease induced by cetuximab. ( 16778425 )
2006
31
Transient acantholytic dermatosis (Grover's disease) in a renal transplant patient. ( 16620222 )
2006
32
Seasonal variation of transient acantholytic dyskeratosis (Grover's disease). ( 16844509 )
2006
33
Effective treatment of persistent Grover's disease with trichloroacetic acid peeling. ( 16918573 )
2006
34
Pruritic papules on the chest and back. Grover's disease. ( 16939188 )
2006
35
Medium-dose ultraviolet A1 phototherapy in transient acantholytic dermatosis (Grover's disease). ( 15627107 )
2005
36
Grover's disease (transient acantholytic dermatosis) associated with atopy. ( 15857481 )
2005
37
Persistent acantholytic dermatosis and extensive lentiginous 'freckling': a new entity? ( 16029360 )
2005
38
Grover's disease: 34 years on. ( 15068451 )
2004
39
Grover's disease: successful treatment with acitretin and calcipotriol. ( 15506319 )
2004
40
Kaposi's varicelliform eruption in a patient with Grover's disease. ( 14576678 )
2003
41
Linear Darier's or Grover's disease? ( 14639427 )
2003
42
Unilateral transient acantholytic dermatosis (Grover's disease) along Blaschko lines. ( 12140485 )
2002
43
Treatment of Grover's disease with tacalcitol. ( 11952712 )
2002
44
Grover's disease associated with Sarcoptes scabiei. ( 11385234 )
2001
45
Grover's disease, despite histological similarity to Darier's disease, does not share an abnormality in the ATP2A2 gene. ( 10971355 )
2000
46
Grover's disease secondary to ribavirin. ( 10848771 )
2000
47
Grover's disease associated with Waldenström's macroglobulinemia and neutrophilic dermatosis. ( 10877140 )
2000
48
A case report: persistent acantholytic dermatosis in chronic renal failure. ( 11269988 )
2000
49
Incidence of transient acantholytic dermatosis (Grover's disease) in a hospital setting. ( 10490299 )
1999
50
Grover's disease: clinicopathologic review of 72 cases. ( 10089990 )
1999

Variations for Grover's Disease

Expression for Grover's Disease

Search GEO for disease gene expression data for Grover's Disease.

Pathways for Grover's Disease

GO Terms for Grover's Disease

Cellular components related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 DSP EGF JUP VCL
2 cell junction GO:0030054 9.67 DSP JUP VCL
3 actin cytoskeleton GO:0015629 9.54 JUP VCL
4 intermediate filament GO:0005882 9.52 DSP JUP
5 ficolin-1-rich granule lumen GO:1904813 9.51 JUP VCL
6 cell-cell adherens junction GO:0005913 9.48 JUP VCL
7 adherens junction GO:0005912 9.46 JUP VCL
8 cornified envelope GO:0001533 9.4 DSP JUP
9 specific granule lumen GO:0035580 9.37 JUP VCL
10 cell-cell junction GO:0005911 9.33 DSP JUP VCL
11 intercalated disc GO:0014704 9.32 DSP JUP
12 desmosome GO:0030057 9.26 DSP JUP
13 zonula adherens GO:0005915 8.96 JUP VCL
14 fascia adherens GO:0005916 8.8 DSP JUP VCL

Biological processes related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.54 DSP JUP VCL
2 keratinization GO:0031424 9.49 DSP JUP
3 cell-cell adhesion GO:0098609 9.48 DSP JUP
4 platelet degranulation GO:0002576 9.46 EGF VCL
5 cornification GO:0070268 9.43 DSP JUP
6 positive regulation of canonical Wnt signaling pathway GO:0090263 9.4 EGF JUP
7 skin development GO:0043588 9.32 DSP JUP
8 adherens junction organization GO:0034332 9.26 DSP JUP
9 regulation of heart rate by cardiac conduction GO:0086091 9.16 DSP JUP
10 regulation of ventricular cardiac muscle cell action potential GO:0098911 8.96 DSP JUP
11 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 8.62 DSP JUP

Molecular functions related to Grover's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 DSP JUP VCL
2 cell adhesion molecule binding GO:0050839 9.26 DSP JUP
3 alpha-catenin binding GO:0045294 8.96 JUP VCL
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 DSP JUP

Sources for Grover's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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