MCID: GRV012
MIFTS: 33

Grover's Disease

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Grover's Disease

MalaCards integrated aliases for Grover's Disease:

Name: Grover's Disease 53 73
Persistent Acantholytic Dermatosis 53
Transient Acantholytic Dermatosis 53
Grover Disease 53
Tad 53

Classifications:



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ICD10 33 L11.1
UMLS 73 C0263325

Summaries for Grover's Disease

NIH Rare Diseases : 53 Grover's disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months. Occasionally, this condition may persist for longer periods, or it may come and go over time. The exact cause is unknown; however, a number of factors may cause or worsen the condition including heat and sweating. While there is no cure for Grover's disease, there may be ways to manage the condition, such as avoidance of factors that worsen symptoms, moisturizers, and topical corticosteroids.

MalaCards based summary : Grover's Disease, also known as persistent acantholytic dermatosis, is related to pemphigus and pemphigus foliaceus. An important gene associated with Grover's Disease is DSP (Desmoplakin), and among its related pathways/superpathways are Developmental Biology and PAK Pathway. Affiliated tissues include skin, liver and kidney.

Wikipedia : 76 Grover\'s disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized... more...

Related Diseases for Grover's Disease

Diseases related to Grover's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 pemphigus 29.9 DSP JUP
2 pemphigus foliaceus 10.1
3 epidermolysis bullosa, lethal acantholytic 10.0 DSP JUP
4 cardiomyopathy, dilated, with woolly hair and keratoderma 10.0 DSP JUP
5 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.0 DSP JUP
6 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.0 DSP JUP
7 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.0 DSP JUP
8 palmoplantar keratoderma and woolly hair 10.0 DSP JUP
9 naxos disease 9.9 DSP JUP
10 ectodermal dysplasia/skin fragility syndrome 9.9 DSP JUP
11 arrhythmogenic right ventricular dysplasia, familial, 9 9.9 DSP JUP
12 epidermolytic hyperkeratosis 9.9
13 arrhythmogenic right ventricular dysplasia, familial, 8 9.9 DSP JUP
14 benign chronic pemphigus 9.9 DSP JUP
15 arrhythmogenic right ventricular dysplasia, familial, 1 9.9 DSP JUP
16 palmoplantar keratosis 9.8 DSP JUP
17 intrinsic cardiomyopathy 9.8 DSP JUP
18 pemphigus vulgaris 9.8 DSP JUP
19 leukemia, acute myeloid 9.8
20 membranous nephropathy 9.8
21 glomerulonephritis 9.8
22 leukemia 9.8
23 myeloid leukemia 9.8
24 atrial standstill 1 9.7 DSP JUP
25 left ventricular noncompaction 9.6 DSP JUP
26 arrhythmogenic right ventricular cardiomyopathy 9.5 DSP JUP
27 darier-white disease 9.4 DSP JUP VCL
28 dilated cardiomyopathy 9.1 DSP JUP VCL
29 meningioma, familial 9.0 DSP EGF

Graphical network of the top 20 diseases related to Grover's Disease:



Diseases related to Grover's Disease

Symptoms & Phenotypes for Grover's Disease

Drugs & Therapeutics for Grover's Disease

Search Clinical Trials , NIH Clinical Center for Grover's Disease

Genetic Tests for Grover's Disease

Anatomical Context for Grover's Disease

MalaCards organs/tissues related to Grover's Disease:

41
Skin, Liver, Kidney, Heart, Bone, Bone Marrow

Publications for Grover's Disease

Articles related to Grover's Disease:

(show all 40)
# Title Authors Year
1
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
2
Grover's disease: dermoscopy, reflectance confocal microscopy and histopathological correlation. ( 29085721 )
2017
3
Dermoscopic characteristics of transient acantholytic dermatosis (Grover's disease). ( 29171389 )
2017
4
Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation. ( 27358215 )
2016
5
A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. ( 27660709 )
2016
6
Dermoscopy of Grover's disease: Variability according to histological subtype. ( 26892381 )
2016
7
Grover's disease and cutaneous melanoma: a fortuitous association or a paraneoplastic case? ( 26159656 )
2015
8
Grover's disease in chronic kidney failure. ( 26299177 )
2015
9
Pruritic Papules Following Lumbar Corset Use: A Quiz. Grover's disease. ( 25708298 )
2015
10
Grover's Disease in a Liver Transplant Patient. ( 24648700 )
2014
11
Grover's Disease with Acrosyringeal Acantholysis: A Rare Histological Presentation of an Uncommon Disease. ( 25484405 )
2014
12
Transient acantholytic dermatosis (Grover's disease) with an isolated eruption. ( 23783409 )
2013
13
Grover's disease in a peritoneal dialysis patient. ( 23897199 )
2013
14
Grover's disease secondarily infected with herpes simplex virus and Staphylococcus aureus: case report and review. ( 23013197 )
2013
15
Is Grover's disease an autoimmune dermatosis? ( 24131368 )
2013
16
Grover's disease in a renal transplant patient, after hemodialysis renewal. ( 22481593 )
2012
17
Grover's Disease after Heart Transplantation: A Case Report. ( 23320241 )
2012
18
Grover's disease following multiple bilateral Blaschko lines: a rare clinical presentation with genetic and electron microscopic analyses. ( 23075809 )
2012
19
Dermatoscopy of Grover's disease and solitary acantholytic dyskeratoma shows a brown, star-like pattern. ( 23157785 )
2012
20
Leukemia cutis in association With Grover's disease. ( 21242761 )
2011
21
Grover's disease and mercury. ( 19827971 )
2010
22
Grover's disease associated with pregnancy. ( 20507412 )
2010
23
Paraneoplastic transient acantholytic dermatosis (Grover's disease) along Blaschko lines. ( 19467976 )
2009
24
A case of Grover's disease with syringoma-like features and leukemia cutis. ( 16776721 )
2006
25
Grover's disease induced by cetuximab. ( 16778425 )
2006
26
Transient acantholytic dermatosis (Grover's disease) in a renal transplant patient. ( 16620222 )
2006
27
Medium-dose ultraviolet A1 phototherapy in transient acantholytic dermatosis (Grover's disease). ( 15627107 )
2005
28
Grover's disease (transient acantholytic dermatosis) associated with atopy. ( 15857481 )
2005
29
Unilateral transient acantholytic dermatosis (Grover's disease) along Blaschko lines. ( 12140485 )
2002
30
Grover's disease, despite histological similarity to Darier's disease, does not share an abnormality in the ATP2A2 gene. ( 10971355 )
2000
31
Incidence of transient acantholytic dermatosis (Grover's disease) in a hospital setting. ( 10490299 )
1999
32
Grover's disease (transient acantholytic dermatosis): relationship of acantholysis to acrosyringia. ( 9870673 )
1998
33
Transient acantholytic dermatosis (Grover's disease) in a patient with gastric carcinoma. ( 9188891 )
1997
34
Transient acantholytic dermatosis (Grover's disease) in a patient with progressive systemic sclerosis treated with D-penicillamine. ( 9248901 )
1997
35
Transient acantholytic dermatosis (Grover's disease): a global perspective. ( 8912557 )
1996
36
Junctional proteins of keratinocytes in Grover's disease, Hailey-Hailey's disease and Darier's disease. ( 7537767 )
1995
37
Desmosomal dissolution in Grover's disease, Hailey-Hailey's disease and Darier's disease. ( 8835169 )
1995
38
Demodicidosis mimicking granulomatous rosacea and transient acantholytic dermatosis (Grover's disease). ( 2958377 )
1987
39
Transient acantholytic dermatosis (Grover's disease). A skin disorder related to heat and sweating. ( 4051530 )
1985
40
Immunofluorescence studies in transient acantholytic dermatosis (Grover's disease). ( 396810 )
1979

Variations for Grover's Disease

Expression for Grover's Disease

Search GEO for disease gene expression data for Grover's Disease.

Pathways for Grover's Disease

GO Terms for Grover's Disease

Cellular components related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 DSP EGF JUP VCL
2 cell junction GO:0030054 9.65 DSP JUP VCL
3 intermediate filament GO:0005882 9.52 DSP JUP
4 ficolin-1-rich granule lumen GO:1904813 9.49 JUP VCL
5 cell-cell adherens junction GO:0005913 9.46 JUP VCL
6 adherens junction GO:0005912 9.43 JUP VCL
7 cornified envelope GO:0001533 9.4 DSP JUP
8 specific granule lumen GO:0035580 9.37 JUP VCL
9 cell-cell junction GO:0005911 9.33 DSP JUP VCL
10 intercalated disc GO:0014704 9.32 DSP JUP
11 desmosome GO:0030057 9.26 DSP JUP
12 zonula adherens GO:0005915 8.96 JUP VCL
13 fascia adherens GO:0005916 8.8 DSP JUP VCL

Biological processes related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.58 DSP JUP VCL
2 keratinization GO:0031424 9.51 DSP JUP
3 positive regulation of canonical Wnt signaling pathway GO:0090263 9.49 EGF JUP
4 platelet degranulation GO:0002576 9.48 EGF VCL
5 cell-cell adhesion GO:0098609 9.46 DSP JUP
6 cornification GO:0070268 9.43 DSP JUP
7 skin development GO:0043588 9.37 DSP JUP
8 adherens junction organization GO:0034332 9.32 DSP JUP
9 regulation of heart rate by cardiac conduction GO:0086091 9.26 DSP JUP
10 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.16 DSP JUP
11 adherens junction assembly GO:0034333 8.96 JUP VCL
12 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 8.62 DSP JUP

Molecular functions related to Grover's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 DSP JUP VCL
2 cell adhesion molecule binding GO:0050839 9.26 DSP JUP
3 alpha-catenin binding GO:0045294 8.96 JUP VCL
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 DSP JUP

Sources for Grover's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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