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TAD
MCID: GRV012
MIFTS: 30

Grover's Disease (TAD)

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Grover's Disease

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MalaCards integrated aliases for Grover's Disease:

Name: Grover's Disease 20 70
Persistent Acantholytic Dermatosis 20
Transient Acantholytic Dermatosis 20
Tad 20

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 L11.1
UMLS 70 C0263325
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Summaries for Grover's Disease

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GARD : 20 Grover's disease is a skin condition that causes the appearance of small, red spots. These spots usually develop on the chest or back, but may also form on other parts of the body. This condition frequently leads to intense itching, although it may cause no symptoms. Most cases last six to twelve months. Occasionally, this condition may persist for longer periods, or it may come and go over time. The exact cause is unknown; however, a number of factors may cause or worsen the condition including heat and sweating. While there is no cure for Grover's disease, there may be ways to manage the condition, such as avoidance of factors that worsen symptoms, moisturizers, and topical corticosteroids.

MalaCards based summary : Grover's Disease, also known as persistent acantholytic dermatosis, is related to pemphigus and pemphigus vulgaris, familial. An important gene associated with Grover's Disease is DSP (Desmoplakin), and among its related pathways/superpathways are Developmental Biology and PAK Pathway. Affiliated tissues include skin, myeloid and kidney.

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Related Diseases for Grover's Disease

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Diseases related to Grover's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 pemphigus 30.2 JUP DSP
2 pemphigus vulgaris, familial 30.2 JUP DSP
3 benign chronic pemphigus 29.6 JUP DSP
4 darier-white disease 29.6 VCL JUP DSP
5 warty dyskeratoma 11.0
6 follicular lymphoma 10.2
7 hairy cell leukemia 10.2
8 piebald trait 10.1
9 prostate cancer 10.1
10 leukemia, acute myeloid 10.1
11 lung cancer susceptibility 3 10.1
12 membranous nephropathy 10.1
13 pemphigoid 10.1
14 dermatitis 10.1
15 glomerulonephritis 10.1
16 allergic contact dermatitis 10.1
17 skin carcinoma 10.1
18 pyoderma 10.1
19 bullous pemphigoid 10.1
20 pyoderma gangrenosum 10.1
21 chickenpox 10.1
22 myeloid leukemia 10.1
23 pityriasis versicolor 10.1
24 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1
25 pemphigus erythematosus 10.1
26 ige responsiveness, atopic 10.1
27 dermatitis, atopic 10.1
28 keratosis 10.1
29 skin disease 10.1
30 scabies 10.1
31 hypereosinophilic syndrome 10.1
32 epidermolysis bullosa, lethal acantholytic 10.0 JUP DSP
33 arrhythmogenic right ventricular dysplasia, familial, 4 9.9 JUP DSP
34 arrhythmogenic right ventricular dysplasia, familial, 6 9.9 JUP DSP
35 palmoplantar keratoderma and woolly hair 9.9 JUP DSP
36 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 9.9 JUP DSP
37 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 9.9 JUP DSP
38 ectodermal dysplasia/skin fragility syndrome 9.9 JUP DSP
39 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 9.9 JUP DSP
40 diffuse palmoplantar keratoderma 9.9 JUP DSP
41 arrhythmogenic right ventricular dysplasia, familial, 8 9.9 JUP DSP
42 arrhythmogenic right ventricular dysplasia, familial, 5 9.9 JUP DSP
43 pityriasis rubra pilaris 9.9
44 porphyria cutanea tarda 9.9
45 scleroderma, familial progressive 9.9
46 dermatitis herpetiformis, familial 9.9
47 dermatitis, atopic, 4 9.9
48 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
49 myelodysplastic syndrome 9.9
50 graft-versus-host disease 9.9

Graphical network of the top 20 diseases related to Grover's Disease:



Diseases related to Grover's Disease
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Symptoms & Phenotypes for Grover's Disease

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Drugs & Therapeutics for Grover's Disease

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Development & Preliminary Clinical Validation Blue Light Phototherapy Systems for T-Cell Not yet recruiting NCT04343586

Search NIH Clinical Center for Grover's Disease

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Genetic Tests for Grover's Disease

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Anatomical Context for Grover's Disease

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MalaCards organs/tissues related to Grover's Disease:

40
Skin, Myeloid, Kidney, Bone Marrow, Thymus, Prostate, Neutrophil
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Publications for Grover's Disease

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Articles related to Grover's Disease:

(show top 50) (show all 209)
# Title Authors PMID Year
1
Case for diagnosis. Atypical Grover's disease. 61
33589293 2021
2
Grover's disease successfully treated with calcipotriene/betamethasone dipropionate ointment. 61
32820850 2020
3
Grover Disease Associated With Chemotherapy: Review of Potential Pathophysiology, Current Treatments, and Future Directions. 61
33196735 2020
4
Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity. 61
33053817 2020
5
Clinical features and treatments of transient acantholytic dermatosis (Grover's disease): a systematic review. 61
32767513 2020
6
Hyperkeratotic Skin Adverse Events Induced by Anticancer Treatments: A Comprehensive Review. 61
31981081 2020
7
Treatment of transient acantholytic dermatosis with liquid nitrogen. 61
32258316 2020
8
BRAF inhibitor and hairy cell leukemia-related transient acantholytic dermatosis. 61
32239892 2020
9
Transient acantholytic dermatosis in a patient with prostate cancer. 61
32239889 2020
10
Neutrophil-rich Variant of Persistent Bullous Grover's Disease. 61
31513276 2019
11
Grover's Disease in a Kidney Transplant Recipient. 61
31542066 2019
12
Pityriasis rubra pilaris-like eruption in the setting of transient acantholytic dermatosis. 61
31440571 2019
13
Grover’s Disease Treated With Total Skin Electron Beam Radiotherapy 61
31013013 2019
14
Suprabasal acantholytic dermatologic toxicities associated checkpoint inhibitor therapy: A spectrum of immune reactions from paraneoplastic pemphigus-like to Grover-like lesions. 61
29943453 2018
15
Monolateral Grover's Disease with Blaschkoid Distribution. 61
30064609 2017
16
Dermoscopic characteristics of transient acantholytic dermatosis (Grover's disease). 61
29171389 2017
17
Grover's disease in a patient with pemphigus vulgaris. 61
28766705 2017
18
Grover's disease: dermoscopy, reflectance confocal microscopy and histopathological correlation. 61
29085721 2017
19
Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature. 61
28102002 2017
20
Histopathological aspects of cutaneous erythematous-papular eruptions induced by immune checkpoint inhibitors for the treatment of metastatic melanoma. 61
28188628 2017
21
Dermoscopic features of a case of transient acantholytic dermatosis. 61
26768084 2017
22
Erratum to: A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. 61
28116090 2017
23
Role of Immune Status in Chemotherapy-Induced Transient Acantholytic Dermatosis. 61
29282194 2017
24
Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation. 61
27358215 2016
25
Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data. 61
27061329 2016
26
Dermoscopy of Grover's disease: Variability according to histological subtype. 61
26892381 2016
27
A case report of Grover's disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1. 61
27660709 2016
28
Grover's-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy. 61
27532022 2016
29
Paraneoplastic Itch Management. 61
27578084 2016
30
Grover's disease and cutaneous melanoma: a fortuitous association or a paraneoplastic case? 61
26159656 2015
31
Pruritic Papules Following Lumbar Corset Use: A Quiz. Grover's disease. 61
25708298 2015
32
Cutaneous crystal storing histiocytosis: a report of two cases. 61
25353627 2015
33
Grover's disease in chronic kidney failure. 61
26299177 2015
34
Grover's Disease with Acrosyringeal Acantholysis: A Rare Histological Presentation of an Uncommon Disease. 61
25484405 2014
35
Epidermal multinucleated giant cells are not always a histopathologic clue to a herpes virus infection: multinucleated epithelial giant cells in the epidermis of lesional skin biopsies from patients with acantholytic dermatoses can histologically mimic a herpes virus infection. 61
25396080 2014
36
Grover disease (transient acantholytic dermatosis) in acute myeloid leukemia on FDG PET/CT. 61
24152615 2014
37
Grover's Disease in a Liver Transplant Patient. 61
24648700 2014
38
Zosteriform transient acantholytic dermatosis. 61
24354617 2014
39
Malassezia skin diseases in humans. 61
24442041 2013
40
Is Grover's disease an autoimmune dermatosis? 61
24131368 2013
41
Pruritus in the older patient: a clinical review. 61
24327039 2013
42
Grover's disease secondarily infected with herpes simplex virus and Staphylococcus aureus: case report and review. 61
23013197 2013
43
Successful novel treatment of recalcitrant transient acantholytic dermatosis (Grover disease) using red light 5-aminolevulinic acid photodynamic therapy. 61
23560385 2013
44
Transient acantholytic dermatosis (Grover's disease) with an isolated eruption. 61
23783409 2013
45
Grover's disease in a peritoneal dialysis patient. 61
23897199 2013
46
Cutaneous toxicities of RAF inhibitors. 61
23276366 2013
47
Transient acantholytic dermatosis associated with pemphigus foliaceus. 61
23067093 2012
48
Cutaneous manifestations of dabrafenib (GSK2118436): a selective inhibitor of mutant BRAF in patients with metastatic melanoma. 61
22804352 2012
49
Dermatoscopy of Grover's disease and solitary acantholytic dyskeratoma shows a brown, star-like pattern. 61
23157785 2012
50
[Pruritic submammary papular lesions]. 61
22653181 2012
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Variations for Grover's Disease

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Expression for Grover's Disease

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Search GEO for disease gene expression data for Grover's Disease.
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Pathways for Grover's Disease

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Pathways related to Grover's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 12.77 VCL JUP EGF DSP
2
PAK Pathway 63
Show member pathways
 12.68 VCL JUP EGF
3
Arrhythmogenic right ventricular cardiomyopathy 36 1
11.59 JUP DSP
4
Lung fibrosis 1
11.17 EGF DSP
5
Antiarrhythmic Pathway, Pharmacodynamics 60
11.07 JUP DSP
6
Adhesion 4
10.89 VCL JUP DSP
7
Stabilization and expansion of the E-cadherin adherens junction 1
10.76 VCL EGF
8
Cell adhesion_Endothelial cell contacts by junctional mechanisms 23
10.46 JUP DSP
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GO Terms for Grover's Disease

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Cellular components related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 VCL JUP EGF DSP
2 cell junction GO:0030054 9.65 VCL JUP DSP
3 intermediate filament GO:0005882 9.51 JUP DSP
4 adherens junction GO:0005912 9.49 VCL JUP
5 ficolin-1-rich granule lumen GO:1904813 9.46 VCL JUP
6 specific granule lumen GO:0035580 9.4 VCL JUP
7 intercalated disc GO:0014704 9.37 JUP DSP
8 cell-cell junction GO:0005911 9.33 VCL JUP DSP
9 cornified envelope GO:0001533 9.32 JUP DSP
10 desmosome GO:0030057 9.26 JUP DSP
11 zonula adherens GO:0005915 8.96 VCL JUP
12 fascia adherens GO:0005916 8.8 VCL JUP DSP

Biological processes related to Grover's Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.58 VCL JUP DSP
2 keratinization GO:0031424 9.51 JUP DSP
3 cell-cell adhesion GO:0098609 9.49 JUP DSP
4 positive regulation of canonical Wnt signaling pathway GO:0090263 9.48 JUP EGF
5 platelet degranulation GO:0002576 9.46 VCL EGF
6 cornification GO:0070268 9.43 JUP DSP
7 skin development GO:0043588 9.37 JUP DSP
8 adherens junction organization GO:0034332 9.32 JUP DSP
9 regulation of heart rate by cardiac conduction GO:0086091 9.26 JUP DSP
10 epithelial cell-cell adhesion GO:0090136 9.16 VCL DSP
11 regulation of ventricular cardiac muscle cell action potential GO:0098911 8.96 JUP DSP
12 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 8.62 JUP DSP

Molecular functions related to Grover's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 VCL JUP DSP
2 cell adhesion molecule binding GO:0050839 9.26 JUP DSP
3 alpha-catenin binding GO:0045294 8.96 VCL JUP
4 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.62 JUP DSP
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Sources for Grover's Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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