MCID: GRW001
MIFTS: 42

Growth Hormone Secreting Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

MalaCards integrated aliases for Growth Hormone Secreting Pituitary Adenoma:

Name: Growth Hormone Secreting Pituitary Adenoma 12 15
Growth Hormone-Secreting Pituitary Adenoma 45 17 74
Somatotroph Adenoma 12 30 6
Growth Hormone Producing Adenoma of the Pituitary 12
Growth Hormone Secreting Adenoma of Pituitary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6255
MeSH 45 D049912
NCIt 51 C7461
UMLS 74 C0346302

Summaries for Growth Hormone Secreting Pituitary Adenoma

MalaCards based summary : Growth Hormone Secreting Pituitary Adenoma, also known as growth hormone-secreting pituitary adenoma, is related to acromegaly and pituitary adenoma. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. The drugs Octreotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and skin, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

Diseases in the Growth Hormone Secreting Pituitary Adenoma family:

Pituitary Adenoma 2, Growth Hormone-Secreting

Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 acromegaly 32.1 AIP GNAS PRL SST SSTR2
2 pituitary adenoma 31.7 AIP GNAS
3 adenoma 31.0 AIP GNAS PRL SST
4 gigantism 30.3 AIP PRL
5 mccune-albright syndrome 30.1 GNAS PRL SST
6 fibrous dysplasia 30.1 GNAS PRL SST
7 pituitary tumors 29.7 AIP GNAS PRL SST
8 pituitary adenoma, prolactin-secreting 28.1 AIP GHSR GNAS PRKAR1A PRL SST
9 pituitary adenoma 2, growth hormone-secreting 11.6
10 pseudohypoparathyroidism, type ia 10.3 GNAS PRL
11 pituitary infarct 10.2 PRL SST
12 chiasmal syndrome 10.2 PRL SST
13 pituitary carcinoma 10.2 PRL SST
14 prolactin producing pituitary tumor 10.2 PRL SST
15 brain meningioma 10.2
16 gangliocytoma 10.2
17 nelson syndrome 10.2 PRL SST
18 villous adenoma 10.2 GNAS SST
19 tsh producing pituitary tumor 10.2 PRL SST
20 type c thymoma 10.2 SST SSTR2
21 spinocerebellar degeneration 10.2 PRL SST
22 pancreatic endocrine carcinoma 10.2 SST SSTR2
23 functioning pituitary adenoma 10.2 PRL SST
24 pseudopseudohypoparathyroidism 10.2 GNAS PRKAR1A
25 pituitary apoplexy 10.2 AIP PRL
26 acrodysostosis 10.1 GNAS PRKAR1A
27 carcinoid tumors, intestinal 10.1 SST SSTR2
28 albright's hereditary osteodystrophy 10.1 GNAS PRKAR1A
29 mixed ductal-endocrine carcinoma 10.1 SST SSTR2
30 pituitary-dependent cushing's disease 10.1 PRL SST
31 pituitary hypoplasia 10.1 GHRHR PRL
32 lentigines 10.0
33 retinoblastoma 10.0
34 smith-magenis syndrome 10.0
35 thyroid cancer, nonmedullary, 1 10.0
36 moyamoya disease 1 10.0
37 meningioma, familial 10.0
38 spinal meningioma 10.0
39 neuroendocrine tumor 10.0
40 thyroid cancer 10.0
41 adenocarcinoma 10.0
42 lipomatosis 10.0
43 secretory meningioma 10.0
44 ganglioglioma 10.0
45 aortitis 10.0
46 granulomatous hypophysitis 10.0
47 headache 10.0
48 hyperthyroidism 10.0 GNAS PRL SST
49 galactorrhea 10.0
50 amenorrhea 10.0

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to Growth Hormone Secreting Pituitary Adenoma

Symptoms & Phenotypes for Growth Hormone Secreting Pituitary Adenoma

MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 GHRHR GHSR GNAS PRKAR1A PRL SST
2 homeostasis/metabolism MP:0005376 9.86 AIP GHRHR GHSR GNAS PRKAR1A PRL
3 endocrine/exocrine gland MP:0005379 9.72 AIP GHRHR GNAS PRKAR1A PRL
4 adipose tissue MP:0005375 9.71 GHRHR GHSR GNAS PRKAR1A
5 integument MP:0010771 9.55 AIP GHRHR GNAS PRKAR1A PRL
6 neoplasm MP:0002006 9.26 AIP GNAS PRKAR1A PRL
7 skeleton MP:0005390 9.02 GHRHR GHSR GNAS PRKAR1A SST

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

Drugs for Growth Hormone Secreting Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 4,Phase 2 83150-76-9 6400441 383414
2 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
3 Gastrointestinal Agents Phase 4,Not Applicable
4 Antineoplastic Agents, Hormonal Phase 4
5
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
6
lanreotide Approved Phase 3 108736-35-2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
8 Hormone Antagonists Phase 3,Phase 2,Not Applicable
9 Pharmaceutical Solutions Phase 3
10 Angiopeptin Phase 3
11
Pasireotide Approved Phase 2 396091-73-9 9941444
12
Rosiglitazone Approved, Investigational Not Applicable 122320-73-4 77999
13
gastric inhibitory polypeptide Approved, Investigational Not Applicable 100040-31-1
14 Hypoglycemic Agents Not Applicable
15 Incretins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preoperative Octreotide Treatment of Acromegaly Completed NCT00521300 Phase 4 Octreotide
2 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
3 An Extension Study to Assess the Long-term Safety and Efficacy of Pasireotide in Patients With Acromegaly Completed NCT00171730 Phase 2 Pasireotide
4 Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in Acromegaly Unknown status NCT01902420
5 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332 Not Applicable
6 Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
7 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Recruiting NCT03309319 Not Applicable Rosiglitazone
8 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188
9 Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor Not yet recruiting NCT03807076 Not Applicable

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Cochrane evidence based reviews: growth hormone-secreting pituitary adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

# Genetic test Affiliating Genes
1 Somatotroph Adenoma 30 AIP

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

42
Pituitary, Thyroid, Skin, Colon, Bone, Brain, Cortex

Publications for Growth Hormone Secreting Pituitary Adenoma

Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50) (show all 57)
# Title Authors Year
1
Internal carotid artery aneurysms diagnosed after stereotactic radiosurgery for a growth hormone-secreting pituitary adenoma: a case report and literature review. ( 30955084 )
2019
2
Benzene affects the response to octreotide treatment of growth hormone secreting pituitary adenoma cells. ( 30986651 )
2019
3
Incidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study. ( 30643415 )
2019
4
Delayed Remission of Growth Hormone-Secreting Pituitary Adenoma After Transsphenoidal Adenectomy. ( 30447463 )
2019
5
Super Giant Growth Hormone-Secreting Pituitary Adenoma in Young Woman: From Ventricles to Nose. ( 30472284 )
2019
6
Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells. ( 30537696 )
2019
7
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. ( 30318257 )
2019
8
Inoperable Giant Growth Hormone-secreting Pituitary Adenoma: Radiological Aspects, Clinical Management and Pregnancy Outcome. ( 30088454 )
2019
9
Collision tumors composed of meningioma and growth hormone-secreting pituitary adenoma in the sellar region: Case reports and a literature review. ( 29390316 )
2017
10
Surgical Outcome of Growth Hormone-Secreting Pituitary Adenoma with Empty Sella Using a New Classification. ( 28642181 )
2017
11
Granulomatous hypophysitis caused by Rathke's cleft cyst mimicking a growth hormone-secreting pituitary adenoma. ( 28484553 )
2017
12
In vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells. ( 27267119 )
2016
13
Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma. ( 27068013 )
2016
14
Effect of Transsphenoidal Adenectomy on Glucose Tolerance Status in Patients with Growth Hormone-secreting Pituitary Adenoma. ( 26956860 )
2016
15
Long-term results of hypofractionated stereotactic radiotherapy with CyberKnife for growth hormone-secreting pituitary adenoma: evaluation by the Cortina consensus. ( 26961771 )
2016
16
Expression of somatostatin receptor subtype 2 in growth hormone-secreting pituitary adenoma and the regulation of miR-185. ( 26036598 )
2015
17
Gigantism caused by growth hormone secreting pituitary adenoma. ( 25077093 )
2014
18
Long-term changes in serum IGF-1 levels after successful surgical treatment of growth hormone-secreting pituitary adenoma. ( 23728452 )
2013
19
Neuroendocrine tumor of unknown origin metastasizing to a growth hormone-secreting pituitary adenoma. ( 22120409 )
2012
20
Moyamoya syndrome following growth hormone-secreting pituitary adenoma. ( 22592188 )
2012
21
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. ( 22824691 )
2012
22
Ectopic growth hormone-secreting pituitary adenoma involving the clivus treated with octreotide: role of magnetic resonance imaging in the diagnosis and clinical follow-up. ( 22990736 )
2012
23
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. ( 20888068 )
2011
24
Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. ( 20067380 )
2010
25
Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation. ( 20150876 )
2010
26
Surgical results of growth hormone-secreting pituitary adenoma. ( 19516943 )
2009
27
The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 18413424 )
2008
28
Short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome treated successfully with transsphenoidal resection of a growth hormone-secreting pituitary adenoma. ( 18590441 )
2008
29
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation. ( 19029774 )
2008
30
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. ( 17334927 )
2007
31
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. ( 17411461 )
2007
32
Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. ( 17986925 )
2007
33
Effect of preoperative use of long-acting octreotide on growth hormone secreting pituitary adenoma and transsphenoidal surgery. ( 15844307 )
2005
34
Stereotactic conformal radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 15234043 )
2004
35
Growth hormone-secreting pituitary adenoma associated with primary moyamoya disease--case report. ( 12924597 )
2003
36
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. ( 14672272 )
2003
37
Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. ( 11922715 )
2002
38
Ectopic growth hormone-secreting pituitary adenoma in the sphenoid sinus. ( 11201818 )
2001
39
Transsphenoidal surgery and adjuvant gamma knife treatment for growth hormone-secreting pituitary adenoma. ( 11780899 )
2001
40
Twenty-kilodalton human growth hormone (20K hGH) secretion from growth hormone-secreting pituitary adenoma cells in vitro. ( 11200936 )
2000
41
Osseous metaplasia in a growth hormone-secreting pituitary adenoma. ( 10442463 )
1999
42
A functional thyrotropin- and growth hormone-secreting pituitary adenoma with a ultrastructurally monomorphic feature: a case study. ( 9700474 )
1998
43
Growth hormone-secreting pituitary adenoma associated with multiple bone cysts, skin pigmentation and aortitis syndrome. ( 9061509 )
1996
44
Results of the lateral rhinotomy approach in transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma. ( 8719832 )
1995
45
Growth hormone secreting pituitary adenoma: Clinical aspects and surgical outcome. ( 17587934 )
1995
46
Hormonal and radiological effects of megavoltage radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 8258643 )
1993
47
Coexistence of growth hormone-secreting pituitary adenoma and intracranial meningioma: a case report and review of the literature. ( 8282967 )
1993
48
Cytocidal effects of bromocriptine, somatostatin analog, and heat on growth hormone-secreting pituitary adenoma in vitro. ( 1571899 )
1992
49
Adenocarcinoma metastatic to a growth-hormone-secreting pituitary adenoma: case report. ( 1631761 )
1992
50
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. ( 2512034 )
1989

Variations for Growth Hormone Secreting Pituitary Adenoma

Expression for Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for Growth Hormone Secreting Pituitary Adenoma

GO Terms for Growth Hormone Secreting Pituitary Adenoma

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.65 GHRHR PRL SST
2 G protein-coupled receptor signaling pathway GO:0007186 9.65 GHRHR GHSR GNAS SST SSTR2
3 response to drug GO:0042493 9.51 GNAS SST
4 lactation GO:0007595 9.49 GHRHR PRL
5 positive regulation of multicellular organism growth GO:0040018 9.46 GHRHR GHSR
6 mammary gland development GO:0030879 9.43 GHRHR PRL
7 activation of adenylate cyclase activity GO:0007190 9.4 GHRHR GNAS
8 renal water homeostasis GO:0003091 9.37 GNAS PRKAR1A
9 cellular response to glucagon stimulus GO:0071377 9.32 GNAS PRKAR1A
10 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.16 GHRHR GHSR
11 female pregnancy GO:0007565 9.13 GHSR GNAS PRL
12 growth hormone secretion GO:0030252 8.62 GHRHR GHSR

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone binding GO:0017046 8.96 GHRHR GHSR
2 growth hormone-releasing hormone receptor activity GO:0016520 8.62 GHRHR GHSR

Sources for Growth Hormone Secreting Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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