MCID: GRW001
MIFTS: 43

Growth Hormone Secreting Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

MalaCards integrated aliases for Growth Hormone Secreting Pituitary Adenoma:

Name: Growth Hormone Secreting Pituitary Adenoma 12 15
Somatotroph Adenoma 12 29 6
Growth Hormone-Secreting Pituitary Adenoma 44 73
Growth Hormone Producing Adenoma of the Pituitary 12
Growth Hormone Secreting Adenoma of Pituitary 12

Classifications:



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Disease Ontology 12 DOID:6255
MeSH 44 D049912
NCIt 50 C7461
UMLS 73 C0346302

Summaries for Growth Hormone Secreting Pituitary Adenoma

MalaCards based summary : Growth Hormone Secreting Pituitary Adenoma, also known as somatotroph adenoma, is related to acromegaly and pituitary adenoma. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. The drugs Octreotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, cortex and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

Diseases in the Growth Hormone Secreting Pituitary Adenoma family:

Pituitary Adenoma 2, Growth Hormone-Secreting

Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 acromegaly 32.3 AIP GNAS PRL SST SSTR2
2 pituitary adenoma 31.6 AIP GNAS
3 adenoma 31.1 AIP GNAS PRL SST
4 gigantism 30.2 AIP PRL
5 mccune-albright syndrome 30.1 GNAS PRL SST
6 fibrous dysplasia 30.1 GNAS PRL SST
7 pituitary tumors 29.8 AIP GNAS PRL SST
8 pituitary adenoma 2, growth hormone-secreting 11.5
9 gangliocytoma 10.2
10 pseudohypoparathyroidism, type ia 10.2 GNAS PRL
11 pituitary infarct 10.1 PRL SST
12 chiasmal syndrome 10.1 PRL SST
13 prolactin producing pituitary tumor 10.1 PRL SST
14 type c thymoma 10.1 SST SSTR2
15 nelson syndrome 10.1 PRL SST
16 villous adenoma 10.1 GNAS SST
17 pancreatic endocrine carcinoma 10.1 SST SSTR2
18 pseudopseudohypoparathyroidism 10.1 GNAS PRKAR1A
19 tsh producing pituitary tumor 10.1 PRL SST
20 pituitary apoplexy 10.1 AIP PRL
21 acrodysostosis 10.1 GNAS PRKAR1A
22 carcinoid tumors, intestinal 10.1 SST SSTR2
23 spinocerebellar degeneration 10.1 PRL SST
24 functioning pituitary adenoma 10.1 PRL SST
25 albright's hereditary osteodystrophy 10.1 GNAS PRKAR1A
26 mixed ductal-endocrine carcinoma 10.1 SST SSTR2
27 pituitary hypoplasia 10.0 GHRHR PRL
28 pituitary-dependent cushing's disease 10.0 PRL SST
29 lentigines 10.0
30 thyroid cancer, nonmedullary, 1 10.0
31 moyamoya disease 1 10.0
32 neuroendocrine tumor 10.0
33 adenocarcinoma 10.0
34 lipomatosis 10.0
35 ganglioglioma 10.0
36 aortitis 10.0
37 granulomatous hypophysitis 10.0
38 headache 10.0
39 pituitary carcinoma 10.0 GNAS PRL SST
40 pituitary stalk interruption syndrome 10.0 GHRHR PRL
41 hyperthyroidism 10.0 GNAS PRL SST
42 hypocalcemia, autosomal dominant 1 10.0 GNAS PRKAR1A
43 galactorrhea 10.0
44 pertussis 10.0
45 amenorrhea 10.0
46 functioning gonadotropic adenoma 10.0
47 adrenal gland disease 10.0 PRKAR1A SST
48 primary pigmented nodular adrenocortical disease 10.0 GNAS PRKAR1A
49 isolated growth hormone deficiency, type ii 10.0 GHRHR SST
50 hyperpituitarism 9.9 AIP PRL SST

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to Growth Hormone Secreting Pituitary Adenoma

Symptoms & Phenotypes for Growth Hormone Secreting Pituitary Adenoma

MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 GHRHR GHSR GNAS PRKAR1A PRL SST
2 homeostasis/metabolism MP:0005376 9.86 AIP GHRHR GHSR GNAS PRKAR1A PRL
3 endocrine/exocrine gland MP:0005379 9.72 AIP GHRHR GNAS PRKAR1A PRL
4 adipose tissue MP:0005375 9.71 GHRHR GHSR GNAS PRKAR1A
5 integument MP:0010771 9.55 AIP GHRHR GNAS PRKAR1A PRL
6 neoplasm MP:0002006 9.26 AIP GNAS PRKAR1A PRL
7 skeleton MP:0005390 9.02 GHRHR GHSR GNAS PRKAR1A SST

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

Drugs for Growth Hormone Secreting Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 4,Phase 2 83150-76-9 383414 6400441
2 Hormones Phase 4,Phase 3,Phase 2
3 Antineoplastic Agents, Hormonal Phase 4
4 Gastrointestinal Agents Phase 4
5 lanreotide Approved Phase 3 108736-35-2
6
Somatostatin Approved, Investigational Phase 3 51110-01-1, 38916-34-6 53481605
7 Hormone Antagonists Phase 3,Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
9 Pharmaceutical Solutions Phase 3
10 Angiopeptin Phase 3
11
Pasireotide Approved Phase 2 396091-73-9 9941444
12
Rosiglitazone Approved, Investigational Not Applicable 122320-73-4 77999
13 Hypoglycemic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preoperative Octreotide Treatment of Acromegaly Completed NCT00521300 Phase 4 Octreotide
2 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
3 An Extension Study to Assess the Long-term Safety and Efficacy of Pasireotide in Patients With Acromegaly Completed NCT00171730 Phase 2 Pasireotide
4 Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in Acromegaly Unknown status NCT01902420
5 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332 Not Applicable
6 Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
7 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Recruiting NCT03309319 Not Applicable Rosiglitazone
8 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188
9 Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor Not yet recruiting NCT03807076 Not Applicable

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Cochrane evidence based reviews: growth hormone-secreting pituitary adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

# Genetic test Affiliating Genes
1 Somatotroph Adenoma 29 AIP

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

41
Pituitary, Cortex, Bone, Colon, Thyroid, Adrenal Gland, Adrenal Cortex

Publications for Growth Hormone Secreting Pituitary Adenoma

Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50) (show all 74)
# Title Authors Year
1
Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells. ( 30537696 )
2018
2
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. ( 30318257 )
2018
3
Delayed Remission of Growth Hormone-Secreting Pituitary Adenoma After Transsphenoidal Adenectomy. ( 30447463 )
2018
4
Inoperable Giant Growth Hormone-secreting Pituitary Adenoma: Radiological Aspects, Clinical Management and Pregnancy Outcome. ( 30088454 )
2018
5
Granulomatous hypophysitis caused by Rathke's cleft cyst mimicking a growth hormone-secreting pituitary adenoma. ( 28484553 )
2017
6
Surgical Outcome of Growth Hormone-Secreting Pituitary Adenoma with Empty Sella Using a New Classification. ( 28642181 )
2017
7
Collision tumors composed of meningioma and growth hormone-secreting pituitary adenoma in the sellar region: Case reports and a literature review. ( 29390316 )
2017
8
In vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells. ( 27267119 )
2016
9
Long-term results of hypofractionated stereotactic radiotherapy with CyberKnife for growth hormone-secreting pituitary adenoma: evaluation by the Cortina consensus. ( 26961771 )
2016
10
Effect of Transsphenoidal Adenectomy on Glucose Tolerance Status in Patients with Growth Hormone-secreting Pituitary Adenoma. ( 26956860 )
2016
11
Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma. ( 27068013 )
2016
12
Expression of somatostatin receptor subtype 2 in growth hormone-secreting pituitary adenoma and the regulation of miR-185. ( 26036598 )
2015
13
Change in the immunophenotype of a somatotroph adenoma resulting in gigantism. ( 25396071 )
2014
14
Gigantism caused by growth hormone secreting pituitary adenoma. ( 25077093 )
2014
15
AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. ( 23674160 )
2013
16
Long-term changes in serum IGF-1 levels after successful surgical treatment of growth hormone-secreting pituitary adenoma. ( 23728452 )
2013
17
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. ( 22824691 )
2012
18
Moyamoya syndrome following growth hormone-secreting pituitary adenoma. ( 22592188 )
2012
19
Neuroendocrine tumor of unknown origin metastasizing to a growth hormone-secreting pituitary adenoma. ( 22120409 )
2012
20
Ectopic growth hormone-secreting pituitary adenoma involving the clivus treated with octreotide: role of magnetic resonance imaging in the diagnosis and clinical follow-up. ( 22990736 )
2012
21
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. ( 20888068 )
2011
22
Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1β and inhibited by growth hormone releasing hormone and somatostatin. ( 21658592 )
2011
23
Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation. ( 20150876 )
2010
24
Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. ( 20067380 )
2010
25
Somatotroph adenoma cells may populate paranasal sinus mucosa. ( 20446098 )
2010
26
Surgical results of growth hormone-secreting pituitary adenoma. ( 19516943 )
2009
27
Silent somatotroph adenoma of the pituitary in an adolescent. ( 19294904 )
2009
28
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation. ( 19029774 )
2008
29
The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 18413424 )
2008
30
Short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome treated successfully with transsphenoidal resection of a growth hormone-secreting pituitary adenoma. ( 18590441 )
2008
31
Spontaneous recovery from severe cardiac failure after acute hypotensive infarction of a somatotroph adenoma. ( 17760886 )
2008
32
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. ( 17334927 )
2007
33
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. ( 17411461 )
2007
34
Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. ( 17986925 )
2007
35
The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly. ( 16118335 )
2005
36
Effect of preoperative use of long-acting octreotide on growth hormone secreting pituitary adenoma and transsphenoidal surgery. ( 15844307 )
2005
37
Mechanisms of TRH-induced GH release (paradoxical response) in human somatotroph adenoma cells. ( 16410670 )
2005
38
Cabergoline decreases somatotroph adenoma size: a case report. ( 15761660 )
2004
39
Stereotactic conformal radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 15234043 )
2004
40
Growth hormone-secreting pituitary adenoma associated with primary moyamoya disease--case report. ( 12924597 )
2003
41
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. ( 14672272 )
2003
42
Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. ( 11922715 )
2002
43
Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. ( 12466351 )
2002
44
Transsphenoidal surgery and adjuvant gamma knife treatment for growth hormone-secreting pituitary adenoma. ( 11780899 )
2001
45
Ectopic growth hormone-secreting pituitary adenoma in the sphenoid sinus. ( 11201818 )
2001
46
Detection of a silent pituitary somatotroph adenoma in a patient with amenorrhea and/or galactorrhea: paradoxical response of GH in TRH or GnRH provocation test. ( 10890196 )
2000
47
Twenty-kilodalton human growth hormone (20K hGH) secretion from growth hormone-secreting pituitary adenoma cells in vitro. ( 11200936 )
2000
48
Double adenoma of the pituitary: a somatotroph adenoma colliding with a gonadotroph adenoma. ( 10698050 )
2000
49
Osseous metaplasia in a growth hormone-secreting pituitary adenoma. ( 10442463 )
1999
50
Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: a model case for autocrine and paracrine regulation of GH secretion by GHRH. ( 10487694 )
1999

Variations for Growth Hormone Secreting Pituitary Adenoma

Expression for Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for Growth Hormone Secreting Pituitary Adenoma

GO Terms for Growth Hormone Secreting Pituitary Adenoma

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.69 GNAS PRL SST
2 cell surface receptor signaling pathway GO:0007166 9.65 GHRHR PRL SST
3 G protein-coupled receptor signaling pathway GO:0007186 9.65 GHRHR GHSR GNAS SST SSTR2
4 lactation GO:0007595 9.49 GHRHR PRL
5 positive regulation of multicellular organism growth GO:0040018 9.46 GHRHR GHSR
6 mammary gland development GO:0030879 9.43 GHRHR PRL
7 activation of adenylate cyclase activity GO:0007190 9.4 GHRHR GNAS
8 renal water homeostasis GO:0003091 9.37 GNAS PRKAR1A
9 cellular response to glucagon stimulus GO:0071377 9.32 GNAS PRKAR1A
10 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.16 GHRHR GHSR
11 female pregnancy GO:0007565 9.13 GHSR GNAS PRL
12 growth hormone secretion GO:0030252 8.62 GHRHR GHSR

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone binding GO:0017046 8.96 GHRHR GHSR
2 growth hormone-releasing hormone receptor activity GO:0016520 8.62 GHRHR GHSR

Sources for Growth Hormone Secreting Pituitary Adenoma

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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
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33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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62 PubMed
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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