MCID: GRW001
MIFTS: 43

Growth Hormone Secreting Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

MalaCards integrated aliases for Growth Hormone Secreting Pituitary Adenoma:

Name: Growth Hormone Secreting Pituitary Adenoma 12 15
Growth Hormone-Secreting Pituitary Adenoma 45 17 74
Somatotroph Adenoma 12 30 6
Growth Hormone Producing Adenoma of the Pituitary 12
Growth Hormone Secreting Adenoma of Pituitary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6255
MeSH 45 D049912
NCIt 51 C7461
UMLS 74 C0346302

Summaries for Growth Hormone Secreting Pituitary Adenoma

MalaCards based summary : Growth Hormone Secreting Pituitary Adenoma, also known as growth hormone-secreting pituitary adenoma, is related to acromegaly and adenoma. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Octreotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, skin and colon, and related phenotypes are behavior/neurological and adipose tissue

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

Diseases in the Growth Hormone Secreting Pituitary Adenoma family:

Pituitary Adenoma 2, Growth Hormone-Secreting

Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 acromegaly 32.1 GHRL GNAS PRL SST SSTR2
2 adenoma 31.5 GNAS PRL SST
3 pituitary tumors 30.1 GNAS PRL SST
4 mccune-albright syndrome 30.1 GNAS PRL SST
5 fibrous dysplasia 30.1 GNAS PRL SST
6 pituitary adenoma 2, growth hormone-secreting 11.6
7 pituitary adenoma 10.9
8 pseudohypoparathyroidism, type ia 10.3 GNAS PRL
9 pituitary infarct 10.2 PRL SST
10 chiasmal syndrome 10.2 PRL SST
11 pituitary carcinoma 10.2 PRL SST
12 prolactin producing pituitary tumor 10.2 PRL SST
13 villous adenoma 10.2 GNAS SST
14 nelson syndrome 10.2 PRL SST
15 hyperpituitarism 10.2 PRL SST
16 tsh producing pituitary tumor 10.2 PRL SST
17 spinocerebellar degeneration 10.2 PRL SST
18 functioning pituitary adenoma 10.2 PRL SST
19 gangliocytoma 10.2
20 type c thymoma 10.2 SST SSTR2
21 pituitary adenoma 1, multiple types 10.2 PRL SST
22 pancreatic endocrine carcinoma 10.2 SST SSTR2
23 pseudopseudohypoparathyroidism 10.2 GNAS PRKAR1A
24 acrodysostosis 10.2 GNAS PRKAR1A
25 carcinoid tumors, intestinal 10.2 SST SSTR2
26 pituitary-dependent cushing's disease 10.2 PRL SST
27 albright's hereditary osteodystrophy 10.2 GNAS PRKAR1A
28 pylorospasm 10.2 GHRL SST
29 carney complex variant 10.1 GNAS PRKAR1A
30 endocrine organ benign neoplasm 10.1 PRL SST
31 mixed ductal-endocrine carcinoma 10.1 SST SSTR2
32 multiple endocrine neoplasia, type iv 10.1 PRKAR1A PRL
33 ectopic cushing syndrome 10.1 GHRL SST
34 pituitary hypoplasia 10.1 GHRHR PRL
35 thyroid gland disease 10.1 PRL SST
36 hypocalcemia, autosomal dominant 1 10.1 GNAS PRKAR1A
37 adrenal gland disease 10.1 PRKAR1A SST
38 pituitary gland disease 10.1 PRL SST
39 primary pigmented nodular adrenocortical disease 10.0 GNAS PRKAR1A
40 pituitary stalk interruption syndrome 10.0 GHRHR PRL
41 cell type benign neoplasm 10.0 GNAS PRL SST
42 lentigines 10.0
43 retinoblastoma 10.0
44 thyroid cancer, nonmedullary, 1 10.0
45 moyamoya disease 1 10.0
46 neuroendocrine tumor 10.0
47 thyroid cancer 10.0
48 adenocarcinoma 10.0
49 lipomatosis 10.0
50 ganglioglioma 10.0

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to Growth Hormone Secreting Pituitary Adenoma

Symptoms & Phenotypes for Growth Hormone Secreting Pituitary Adenoma

MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 GHRHR GHRL GHSR GNAS PRKAR1A PRL
2 adipose tissue MP:0005375 9.65 GHRHR GHRL GHSR GNAS PRKAR1A
3 digestive/alimentary MP:0005381 9.35 GHRL GHSR PRKAR1A SST SSTR2
4 homeostasis/metabolism MP:0005376 9.23 GHRHR GHRL GHSR GNAS PRKAR1A PRL

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

Drugs for Growth Hormone Secreting Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 4,Phase 2 83150-76-9 6400441 383414
2 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
3 Antineoplastic Agents, Hormonal Phase 4
4 Gastrointestinal Agents Phase 4,Not Applicable
5
lanreotide Approved Phase 3 108736-35-2
6
Somatostatin Approved, Investigational Phase 3 38916-34-6, 51110-01-1 53481605
7 Hormone Antagonists Phase 3,Phase 2,Not Applicable
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Not Applicable
9 Angiopeptin Phase 3
10 Pharmaceutical Solutions Phase 3
11
Pasireotide Approved Phase 2 396091-73-9 9941444
12
Rosiglitazone Approved, Investigational Not Applicable 122320-73-4 77999
13 Hypoglycemic Agents Not Applicable
14 Incretins Not Applicable
15 gastric inhibitory polypeptide Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Preoperative Octreotide Treatment of Acromegaly Completed NCT00521300 Phase 4 Octreotide
2 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
3 An Extension Study to Assess the Long-term Safety and Efficacy of Pasireotide in Patients With Acromegaly Completed NCT00171730 Phase 2 Pasireotide
4 Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations in Acromegaly Unknown status NCT01902420
5 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332 Not Applicable
6 Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
7 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Recruiting NCT03309319 Not Applicable Rosiglitazone
8 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188
9 Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor Not yet recruiting NCT03807076 Not Applicable

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Cochrane evidence based reviews: growth hormone-secreting pituitary adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

# Genetic test Affiliating Genes
1 Somatotroph Adenoma 30

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

42
Pituitary, Skin, Colon, Bone, Thyroid

Publications for Growth Hormone Secreting Pituitary Adenoma

Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50) (show all 55)
# Title Authors Year
1
Super Giant Growth Hormone-Secreting Pituitary Adenoma in Young Woman: From Ventricles to Nose. ( 30472284 )
2019
2
Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells. ( 30537696 )
2019
3
Incidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study. ( 30643415 )
2019
4
Delayed Remission of Growth Hormone-Secreting Pituitary Adenoma After Transsphenoidal Adenectomy. ( 30447463 )
2018
5
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. ( 30318257 )
2018
6
Inoperable Giant Growth Hormone-secreting Pituitary Adenoma: Radiological Aspects, Clinical Management and Pregnancy Outcome. ( 30088454 )
2018
7
Granulomatous hypophysitis caused by Rathke's cleft cyst mimicking a growth hormone-secreting pituitary adenoma. ( 28484553 )
2017
8
Surgical Outcome of Growth Hormone-Secreting Pituitary Adenoma with Empty Sella Using a New Classification. ( 28642181 )
2017
9
Collision tumors composed of meningioma and growth hormone-secreting pituitary adenoma in the sellar region: Case reports and a literature review. ( 29390316 )
2017
10
In vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells. ( 27267119 )
2016
11
Long-term results of hypofractionated stereotactic radiotherapy with CyberKnife for growth hormone-secreting pituitary adenoma: evaluation by the Cortina consensus. ( 26961771 )
2016
12
Effect of Transsphenoidal Adenectomy on Glucose Tolerance Status in Patients with Growth Hormone-secreting Pituitary Adenoma. ( 26956860 )
2016
13
Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma. ( 27068013 )
2016
14
Expression of somatostatin receptor subtype 2 in growth hormone-secreting pituitary adenoma and the regulation of miR-185. ( 26036598 )
2015
15
Gigantism caused by growth hormone secreting pituitary adenoma. ( 25077093 )
2014
16
Long-term changes in serum IGF-1 levels after successful surgical treatment of growth hormone-secreting pituitary adenoma. ( 23728452 )
2013
17
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. ( 22824691 )
2012
18
Moyamoya syndrome following growth hormone-secreting pituitary adenoma. ( 22592188 )
2012
19
Neuroendocrine tumor of unknown origin metastasizing to a growth hormone-secreting pituitary adenoma. ( 22120409 )
2012
20
Ectopic growth hormone-secreting pituitary adenoma involving the clivus treated with octreotide: role of magnetic resonance imaging in the diagnosis and clinical follow-up. ( 22990736 )
2012
21
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. ( 20888068 )
2011
22
Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation. ( 20150876 )
2010
23
Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. ( 20067380 )
2010
24
Surgical results of growth hormone-secreting pituitary adenoma. ( 19516943 )
2009
25
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation. ( 19029774 )
2008
26
The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 18413424 )
2008
27
Short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome treated successfully with transsphenoidal resection of a growth hormone-secreting pituitary adenoma. ( 18590441 )
2008
28
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. ( 17334927 )
2007
29
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. ( 17411461 )
2007
30
Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. ( 17986925 )
2007
31
Effect of preoperative use of long-acting octreotide on growth hormone secreting pituitary adenoma and transsphenoidal surgery. ( 15844307 )
2005
32
Stereotactic conformal radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 15234043 )
2004
33
Growth hormone-secreting pituitary adenoma associated with primary moyamoya disease--case report. ( 12924597 )
2003
34
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. ( 14672272 )
2003
35
Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. ( 11922715 )
2002
36
Transsphenoidal surgery and adjuvant gamma knife treatment for growth hormone-secreting pituitary adenoma. ( 11780899 )
2001
37
Ectopic growth hormone-secreting pituitary adenoma in the sphenoid sinus. ( 11201818 )
2001
38
Twenty-kilodalton human growth hormone (20K hGH) secretion from growth hormone-secreting pituitary adenoma cells in vitro. ( 11200936 )
2000
39
Osseous metaplasia in a growth hormone-secreting pituitary adenoma. ( 10442463 )
1999
40
A functional thyrotropin- and growth hormone-secreting pituitary adenoma with a ultrastructurally monomorphic feature: a case study. ( 9700474 )
1998
41
Growth hormone-secreting pituitary adenoma associated with multiple bone cysts, skin pigmentation and aortitis syndrome. ( 9061509 )
1996
42
Growth hormone secreting pituitary adenoma: Clinical aspects and surgical outcome. ( 17587934 )
1995
43
Results of the lateral rhinotomy approach in transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma. ( 8719832 )
1995
44
Hormonal and radiological effects of megavoltage radiotherapy in patients with growth hormone-secreting pituitary adenoma. ( 8258643 )
1993
45
Coexistence of growth hormone-secreting pituitary adenoma and intracranial meningioma: a case report and review of the literature. ( 8282967 )
1993
46
Cytocidal effects of bromocriptine, somatostatin analog, and heat on growth hormone-secreting pituitary adenoma in vitro. ( 1571899 )
1992
47
Adenocarcinoma metastatic to a growth-hormone-secreting pituitary adenoma: case report. ( 1631761 )
1992
48
Reversible shrinkage of a growth hormone-secreting pituitary adenoma by a long-acting somatostatin analogue, octreotide. ( 2730266 )
1989
49
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. ( 2512034 )
1989
50
Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. ( 3373281 )
1988

Variations for Growth Hormone Secreting Pituitary Adenoma

Expression for Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for Growth Hormone Secreting Pituitary Adenoma

GO Terms for Growth Hormone Secreting Pituitary Adenoma

Cellular components related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 8.8 GHRL GHSR PRKAR1A

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.83 GHRHR PRL SST
2 G protein-coupled receptor signaling pathway GO:0007186 9.73 GHRHR GHRL GHSR GNAS SST SSTR2
3 female pregnancy GO:0007565 9.71 GHSR GNAS PRL
4 response to estrogen GO:0043627 9.68 GHRHR GHRL
5 response to hormone GO:0009725 9.67 GHRL GHSR
6 response to nutrient levels GO:0031667 9.67 GHRL PRL
7 hormone-mediated signaling pathway GO:0009755 9.67 GHRL GHSR
8 response to drug GO:0042493 9.66 GNAS SST
9 lactation GO:0007595 9.66 GHRHR PRL
10 negative regulation of endothelial cell proliferation GO:0001937 9.65 GHRL PRL
11 mammary gland development GO:0030879 9.65 GHRHR PRL
12 activation of adenylate cyclase activity GO:0007190 9.64 GHRHR GNAS
13 renal water homeostasis GO:0003091 9.64 GNAS PRKAR1A
14 negative regulation of insulin secretion GO:0046676 9.63 GHRL GHSR
15 positive regulation of sprouting angiogenesis GO:1903672 9.63 GHRL GHSR
16 cellular response to glucagon stimulus GO:0071377 9.62 GNAS PRKAR1A
17 decidualization GO:0046697 9.62 GHRL GHSR
18 positive regulation of vascular endothelial cell proliferation GO:1905564 9.61 GHRL GHSR
19 regulation of postsynapse organization GO:0099175 9.61 GHRL GHSR
20 actin polymerization or depolymerization GO:0008154 9.6 GHRL GHSR
21 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.59 GHRHR GHSR
22 positive regulation of growth GO:0045927 9.58 GHRL GHSR
23 adult feeding behavior GO:0008343 9.58 GHRL GHSR
24 negative regulation of interleukin-1 beta production GO:0032691 9.57 GHRL GHSR
25 positive regulation of growth hormone secretion GO:0060124 9.56 GHRHR GHRL
26 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.55 GHRL GHSR
27 negative regulation of tumor necrosis factor secretion GO:1904468 9.52 GHRL GHSR
28 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.51 GHRL GHSR
29 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.49 GHRL GHSR
30 positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046010 9.48 GHRHR GHRL
31 positive regulation of appetite GO:0032100 9.46 GHRL GHSR
32 positive regulation of eating behavior GO:1904000 9.43 GHRL GHSR
33 regulation of transmission of nerve impulse GO:0051969 9.4 GHRL GHSR
34 positive regulation of small intestine smooth muscle contraction GO:1904349 9.37 GHRL GHSR
35 regulation of gastric motility GO:1905333 9.32 GHRL GHSR
36 positive regulation of small intestinal transit GO:0120058 9.16 GHRL GHSR
37 positive regulation of multicellular organism growth GO:0040018 9.13 GHRHR GHRL GHSR
38 growth hormone secretion GO:0030252 8.8 GHRHR GHRL GHSR

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.26 GHRL GNAS
2 peptide hormone binding GO:0017046 9.16 GHRHR GHSR
3 hormone activity GO:0005179 9.13 GHRL PRL SST
4 growth hormone-releasing hormone receptor activity GO:0016520 8.62 GHRHR GHSR

Sources for Growth Hormone Secreting Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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