MCID: GRW001
MIFTS: 47

Growth Hormone Secreting Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

MalaCards integrated aliases for Growth Hormone Secreting Pituitary Adenoma:

Name: Growth Hormone Secreting Pituitary Adenoma 12 15
Growth Hormone-Secreting Pituitary Adenoma 44 17 70
Somatotroph Adenoma 12 29 6
Growth Hormone Producing Adenoma of the Pituitary 12
Growth Hormone Secreting Adenoma of Pituitary 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6255
MeSH 44 D049912
NCIt 50 C7461
SNOMED-CT 67 254957009
UMLS 70 C0346302

Summaries for Growth Hormone Secreting Pituitary Adenoma

MalaCards based summary : Growth Hormone Secreting Pituitary Adenoma, also known as growth hormone-secreting pituitary adenoma, is related to pituitary adenoma 2, growth hormone-secreting and insulin-like growth factor i. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and kidney, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 73 Acromegaly is a disorder that results from excess growth hormone (GH) after the growth plates have... more...

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

Diseases in the Growth Hormone Secreting Pituitary Adenoma family:

Pituitary Adenoma 2, Growth Hormone-Secreting

Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 pituitary adenoma 2, growth hormone-secreting 32.9 SERPINB9 GPR101
2 insulin-like growth factor i 30.9 SST PRL IGF1 GHRH
3 meningioma, familial 30.7 SSTR5 SSTR2 SST PRKAR1A MEN1
4 gangliocytoma 30.7 PRL POMC GHRH
5 empty sella syndrome 30.5 PRL POMC IGF1
6 gigantism 30.5 PRL GPR101 GHRH AIP
7 galactorrhea 30.5 PRL IGF1
8 hypopituitarism 30.5 PRL POMC IGF1 GHRHR GHRH
9 acromegaly 30.5 SSTR5 SSTR2 SST PRL PRKAR1A POMC
10 amenorrhea 30.4 PRL POMC IGF1 GHRL
11 fibrous dysplasia 30.3 SST PRL IGF1 GNAS GHRH
12 mccune-albright syndrome 30.3 SST PRL PRKAR1A MEN1 IGF1 GNAS
13 tsh producing pituitary tumor 30.3 SSTR5 SST PRL POMC GHRHR
14 parathyroid adenoma 30.3 PRKAR1A MEN1 IGF1 GNAS
15 hyperprolactinemia 30.2 SST PRL POMC IGF1 GNAS GHRH
16 pituitary tumors 30.2 SSTR5 SST PRL POMC MEN1 IGF1
17 multiple endocrine neoplasia 30.2 SST PRKAR1A POMC MEN1 GNAS AIP
18 pituitary adenoma 1, multiple types 30.2 SST SERPINB9 PRL MEN1 IGF1 AIP
19 adenoma 30.2 SSTR5 SSTR2 SST PRL PRKAR1A POMC
20 pituitary hormone deficiency, combined, 2 30.1 PRL POMC IGF1 GHRHR GHRH
21 hyperthyroidism 30.1 SST PRL POMC IGF1 GNAS GHRL
22 hypothyroidism 30.0 SST PRL POMC IGF1 GNAS GHRH
23 pituitary adenoma 29.9 SSTR5 SSTR2 SST PRL PRKAR1A POMC
24 neuroendocrine tumor 29.8 SSTR2 SST POMC MEN1 IGF1 GHRL
25 primary hyperparathyroidism 29.5 PRL PRKAR1A POMC MEN1 IGF1 GHRH
26 carney complex variant 29.2 SST PRL PRKAR1A POMC MEN1 IGF1
27 functioning pituitary adenoma 28.9 SSTR5 SSTR2 SST PRL PRKAR1A POMC
28 pituitary adenoma, prolactin-secreting 28.8 SSTR5 SSTR2 SST PRL PRKAR1A POMC
29 hormone producing pituitary cancer 28.8 SSTR5 SSTR2 SST PRL PRKAR1A POMC
30 fibrous dysplasia/mccune-albright syndrome 10.4 PRL GNAS
31 gastrointestinal neuroendocrine benign tumor 10.4 SST MEN1
32 non-functioning pancreatic endocrine tumor 10.4 SST MEN1
33 null pituitary adenoma 10.4 MEN1 AIP
34 intracranial meningioma 10.4
35 secretory meningioma 10.4
36 lymphoplasmacyte-rich meningioma 10.4
37 abnormality of glucagon secretion 10.4 SST GHRL
38 breast ductal adenoma 10.4 PRL PRKAR1A
39 duodenal gastrinoma 10.4 SST MEN1
40 gastric neuroendocrine neoplasm 10.4 SST MEN1
41 idiopathic gastroparesis 10.4 GHSR GHRL
42 silent pituitary adenoma 10.4 MEN1 AIP
43 acth-independent cushing syndrome 10.4 PRKAR1A GNAS
44 type c thymoma 10.4 SSTR2 SST
45 carcinoid tumors, intestinal 10.4 SSTR2 SST MEN1
46 pulmonary neuroendocrine tumor 10.4 SSTR2 SST MEN1
47 familial isolated pituitary adenoma 10.4 MEN1 AIP
48 duodenal somatostatinoma 10.4 SST MEN1
49 pancreatic gastrinoma 10.4 SST MEN1
50 bronchial adenomas/carcinoids childhood 10.3 SST POMC

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to Growth Hormone Secreting Pituitary Adenoma

Symptoms & Phenotypes for Growth Hormone Secreting Pituitary Adenoma

MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.19 AIP GHRH GHRHR GHRL GHSR GNAS
2 endocrine/exocrine gland MP:0005379 10.1 AIP GHRH GHRHR GHRL GNAS IGF1
3 adipose tissue MP:0005375 10.07 GHRH GHRHR GHRL GHSR GNAS IGF1
4 immune system MP:0005387 9.9 GHRH GHRHR GNAS GPR101 IGF1 MEN1
5 liver/biliary system MP:0005370 9.56 AIP GHRH GNAS KISS1 MEN1 POMC
6 neoplasm MP:0002006 9.17 AIP GNAS IGF1 MEN1 POMC PRKAR1A

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

Drugs for Growth Hormone Secreting Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
lanreotide Approved Phase 3 108736-35-2
2 Hormones Phase 3
3 Pharmaceutical Solutions Phase 3
4 Angiopeptin Phase 3
5
Rosiglitazone Approved, Investigational 122320-73-4 77999
6
gastric inhibitory polypeptide Investigational 100040-31-1
7 Hypoglycemic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma From an Endocrinological Point of View (MERGE Study): a Randomized, Phase 3 Trial Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
2 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332
3 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Unknown status NCT03309319 Rosiglitazone
4 Characteristics of Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
5 Modulating the Glucose-dependent Insulinotropic Polypeptide (GIP) System in Patients With Acromegaly Due to a Pituitary Tumor Recruiting NCT03807076

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Cochrane evidence based reviews: growth hormone-secreting pituitary adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

# Genetic test Affiliating Genes
1 Somatotroph Adenoma 29 AIP

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

40
Pituitary, Thyroid, Kidney, Skin

Publications for Growth Hormone Secreting Pituitary Adenoma

Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50) (show all 269)
# Title Authors PMID Year
1
AIP mutation in pituitary adenomas in the 18th century and today. 6 61
21208107 2011
2
Phenotypic and genotypic features of a large kindred with a germline AIP variant. 6
32324286 2020
3
Three Novel MEN1 Variants in AIP-Negative Familial Isolated Pituitary Adenoma Patients. 6
30630164 2019
4
Screening of AIP Gene Variations in a Cohort of Turkish Patients with Young-Onset Sporadic Hormone-Secreting Pituitary Adenomas. 6
30461320 2018
5
Aryl hydrocarbon receptor-interacting protein gene mutations in familial isolated pituitary adenomas: analysis in 73 families. 6
17244780 2007
6
Mutations in the aryl hydrocarbon receptor interacting protein gene are not highly prevalent among subjects with sporadic pituitary adenomas. 6
17299063 2007
7
Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations. 6
17360484 2007
8
Pituitary adenoma predisposition caused by germline mutations in the AIP gene. 6
16728643 2006
9
New information concerning the Irish giant. 6
5320367 1965
10
Effectiveness of the intraoperative magnetic resonance imaging during endoscopic endonasal approach for acromegaly. 61
33811621 2021
11
Pituitary tumour types in dogs and cats. 61
33641809 2021
12
Associations of GNAS Mutations with Surgical Outcomes in Patients with Growth Hormone-Secreting Pituitary Adenoma. 61
33752302 2021
13
Prognostic Factors of Acromegalic Patients with Growth Hormone-Secreting Pituitary Adenoma After Transsphenoidal Surgery. 61
33309643 2021
14
CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas. 61
33416096 2021
15
Incidence, mortality, and cardiovascular diseases in pituitary adenoma in Korea: a nationwide population-based study. 61
32949324 2021
16
Intensity-modulated Radiotherapy for Pituitary Somatotroph Adenomas. 61
32930785 2020
17
DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas. 61
32673291 2020
18
Identification of a TMEM127 variant in a patient with paraganglioma and acromegaly. 61
33416299 2020
19
Efficacy of cabergoline and triptans for cluster-like headache caused by prolactin-secreting pituitary adenoma: A literature review and case report. 61
32599424 2020
20
Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development. 61
32389802 2020
21
Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. 61
32336638 2020
22
Gastrointestinal symptoms in acromegaly: A case control study. 61
32550042 2020
23
Isolated second-phase diabetes insipidus post-transsphenoidal surgery. 61
32606131 2020
24
The absence of PRDM2 involved the tumorigenesis of somatotroph adenomas through regulating c-Myc. 61
32044406 2020
25
[The diagnostic evaluation of tall stature in children]. 61
32749791 2020
26
Prevalence and characteristics of sellar masses in the city of Al Ain, United Arab Emirates: 2010 to 2016. 61
32241168 2020
27
Clinicopathological analysis of 250 cases of pituitary adenoma under the new WHO classification. 61
32194684 2020
28
Exosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly. 61
31469974 2020
29
Acromegaly in preadolescence: A case report of a 9-year-old boy with acromegaly. 61
32363056 2020
30
Mammosomatotroph and mixed somatotroph-lactotroph adenoma in acromegaly: a retrospective study with long-term follow-up. 61
31368083 2019
31
Risk of internal carotid artery stenosis or occlusion after single-fraction radiosurgery for benign parasellar tumors. 61
31653808 2019
32
Acromegaly caused by a somatotroph adenoma in patient with neurofibromatosis type 1. 61
31189769 2019
33
A Descriptive Study to Find Possible Correlation between Pituitary Magnetic Resonance Image Findings and Abnormal Pituitary Hormones: A Retrospective Single Centre Study in Saudi Community Based Hospital. 61
31571448 2019
34
Lineage-dependent role of miR-410-3p as oncomiR in gonadotroph and corticotroph pituitary adenomas or tumor suppressor miR in somatotroph adenomas via MAPK, PTEN/AKT, and STAT3 signaling pathways. 61
31165412 2019
35
Simultaneous diagnosis of glioblastoma, cervical schwannoma, adrenal masses and growth hormone-secreting adenoma in a previously healthy patient. 61
31439570 2019
36
Internal carotid artery aneurysms diagnosed after stereotactic radiosurgery for a growth hormone-secreting pituitary adenoma: a case report and literature review. 61
30955084 2019
37
Benzene affects the response to octreotide treatment of growth hormone secreting pituitary adenoma cells. 61
30986651 2019
38
Very Unusual Sellar/Suprasellar Region Masses: A Review. 61
31233145 2019
39
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. 61
30318257 2019
40
Silent pituitary plurihormonal adenoma: clinical relevance of immunohistochemical analysis 61
31071255 2019
41
Early surgical intervention for patients with possible clinically silent somatotroph adenoma: a case series. 61
30862315 2019
42
Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study. 61
29757421 2019
43
Pasireotide Responsiveness in Acromegaly Is Mainly Driven by Somatostatin Receptor Subtype 2 Expression. 61
30346538 2019
44
Carney Complex. 61
30428497 2019
45
Cell specific interaction of pasireotide: review of preclinical studies in somatotroph and corticotroph pituitary cells. 61
30483918 2019
46
Delayed Remission of Growth Hormone-Secreting Pituitary Adenoma After Transsphenoidal Adenectomy. 61
30447463 2019
47
Super Giant Growth Hormone-Secreting Pituitary Adenoma in Young Woman: From Ventricles to Nose. 61
30472284 2019
48
Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells. 61
30537696 2019
49
Incidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study. 61
30643415 2019
50
SUBCLINICAL ACROMEGALY DUE TO A PITUITARY CYSTIC SOMATOTROPH ADENOMA. 61
31966995 2019

Variations for Growth Hormone Secreting Pituitary Adenoma

ClinVar genetic disease variations for Growth Hormone Secreting Pituitary Adenoma:

6 (show top 50) (show all 107)
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 AIP NM_003977.4(AIP):c.241C>T (p.Arg81Ter) SNV Pathogenic 41167 rs267606541 GRCh37: 11:67254618-67254618
GRCh38: 11:67487147-67487147
2 AIP NM_003977.4(AIP):c.721A>G (p.Lys241Glu) SNV Pathogenic 41200 rs267606573 GRCh37: 11:67257862-67257862
GRCh38: 11:67490391-67490391
3 AIP NM_003977.4(AIP):c.805_825dup (p.Phe269_His275dup) Duplication Pathogenic 41208 rs267606578 GRCh37: 11:67258273-67258274
GRCh38: 11:67490802-67490803
4 AIP NM_003977.4(AIP):c.811C>T (p.Arg271Trp) SNV Pathogenic 41210 rs267606579 GRCh37: 11:67258282-67258282
GRCh38: 11:67490811-67490811
5 AIP NM_003977.4(AIP):c.40C>T (p.Gln14Ter) SNV Pathogenic 4886 rs104894194 GRCh37: 11:67250669-67250669
GRCh38: 11:67483198-67483198
6 MEN1 NM_000244.3(MEN1):c.1846T>A (p.Ter616Arg) SNV Pathogenic 446502 rs1565635212 GRCh37: 11:64571808-64571808
GRCh38: 11:64804336-64804336
7 AIP NM_003977.4(AIP):c.910C>T (p.Arg304Ter) SNV Pathogenic 4888 rs104894195 GRCh37: 11:67258381-67258381
GRCh38: 11:67490910-67490910
8 AIP NM_003977.4(AIP):c.279+2T>C SNV Pathogenic 1032170 GRCh37: 11:67254658-67254658
GRCh38: 11:67487187-67487187
9 AIP NM_003977.4(AIP):c.469-1G>A SNV Pathogenic/Likely pathogenic 4887 rs267606555 GRCh37: 11:67257508-67257508
GRCh38: 11:67490037-67490037
10 AIP NM_003977.4(AIP):c.66_71del (p.Gly23_Glu24del) Deletion Pathogenic/Likely pathogenic 4889 rs267606567 GRCh37: 11:67250695-67250700
GRCh38: 11:67483224-67483229
11 AIP NM_003977.4(AIP):c.824dup (p.His275fs) Duplication Pathogenic/Likely pathogenic 4890 rs267606580 GRCh37: 11:67258294-67258295
GRCh38: 11:67490823-67490824
12 AIP NM_003977.4(AIP):c.543del (p.Ile182fs) Deletion Pathogenic/Likely pathogenic 4891 rs267606559 GRCh37: 11:67257582-67257582
GRCh38: 11:67490111-67490111
13 AIP NM_003977.4(AIP):c.64C>T (p.Arg22Ter) SNV Pathogenic/Likely pathogenic 4894 rs121908357 GRCh37: 11:67250693-67250693
GRCh38: 11:67483222-67483222
14 AIP NM_003977.2(AIP):c.-1212_279+578del Deletion Likely pathogenic 41158 GRCh37: 11:67249418-67255234
GRCh38: 11:67481947-67487763
15 AIP NM_003977.2(AIP):c.(?_1)_(*_?)del Deletion Likely pathogenic 41160 GRCh37:
GRCh38:
16 AIP NM_003977.4(AIP):c.100-1025_279+357del Deletion Likely pathogenic 41161 GRCh37: 11:67253423-67254984
GRCh38: 11:67485952-67487513
17 AIP NM_003977.4(AIP):c.140_163del (p.Gly47_Arg54del) Deletion Likely pathogenic 41163 rs267606537 GRCh37: 11:67254515-67254538
GRCh38: 11:67487044-67487067
18 AIP NM_003977.4(AIP):c.245_249del (p.Glu82fs) Deletion Likely pathogenic 41168 rs267606542 GRCh37: 11:67254621-67254625
GRCh38: 11:67487150-67487154
19 AIP NM_003977.4(AIP):c.250G>A (p.Glu84Lys) SNV Likely pathogenic 41170 rs267606543 GRCh37: 11:67254627-67254627
GRCh38: 11:67487156-67487156
20 AIP NM_003977.4(AIP):c.280-1G>A SNV Likely pathogenic 41171 rs267606544 GRCh37: 11:67256737-67256737
GRCh38: 11:67489266-67489266
21 AIP NM_003977.4(AIP):c.286_287del (p.Val96fs) Deletion Likely pathogenic 41172 rs267606545 GRCh37: 11:67256744-67256745
GRCh38: 11:67489273-67489274
22 AIP NM_003977.4(AIP):c.2T>C (p.Met1Thr) SNV Likely pathogenic 41173 rs267606546 GRCh37: 11:67250631-67250631
GRCh38: 11:67483160-67483160
23 AIP NM_003977.4(AIP):c.308A>G (p.Lys103Arg) SNV Likely pathogenic 41174 rs267606548 GRCh37: 11:67256766-67256766
GRCh38: 11:67489295-67489295
24 AIP NM_003977.4(AIP):c.350del (p.Gly117fs) Deletion Likely pathogenic 41175 rs267606549 GRCh37: 11:67256806-67256806
GRCh38: 11:67489335-67489335
25 AIP NM_003977.4(AIP):c.3_4insC (p.Ala2fs) Insertion Likely pathogenic 41177 rs267606547 GRCh37: 11:67250632-67250633
GRCh38: 11:67483161-67483162
26 AIP NM_003977.4(AIP):c.404del (p.His135fs) Deletion Likely pathogenic 41178 rs267606551 GRCh37: 11:67256862-67256862
GRCh38: 11:67489391-67489391
27 AIP NM_003977.4(AIP):c.424C>T (p.Gln142Ter) SNV Likely pathogenic 41179 rs267606552 GRCh37: 11:67256882-67256882
GRCh38: 11:67489411-67489411
28 AIP NM_003977.4(AIP):c.721A>T (p.Lys241Ter) SNV Likely pathogenic 41201 rs267606573 GRCh37: 11:67257862-67257862
GRCh38: 11:67490391-67490391
29 AIP NM_003977.4(AIP):c.739_741TAC[1] (p.Tyr248del) Microsatellite Likely pathogenic 41202 rs267606574 GRCh37: 11:67257880-67257882
GRCh38: 11:67490409-67490411
30 AIP NM_003977.3(AIP):c.74_81delTCCCGGACins7 Indel Likely pathogenic 41203 GRCh37: 11:67250703-67250710
GRCh38: 11:67483232-67483239
31 AIP NM_003977.4(AIP):c.468+1G>A SNV Likely pathogenic 41182 rs267606554 GRCh37: 11:67256927-67256927
GRCh38: 11:67489456-67489456
32 AIP NM_003977.4(AIP):c.469-2A>G SNV Likely pathogenic 41183 rs267606556 GRCh37: 11:67257507-67257507
GRCh38: 11:67490036-67490036
33 AIP NM_003977.4(AIP):c.166C>A (p.Arg56Ser) SNV Likely pathogenic 41165 rs267606538 GRCh37: 11:67254543-67254543
GRCh38: 11:67487072-67487072
34 AIP NM_003977.4(AIP):c.715C>T (p.Gln239Ter) SNV Likely pathogenic 41199 rs267606571 GRCh37: 11:67257856-67257856
GRCh38: 11:67490385-67490385
35 AIP NM_003977.4(AIP):c.490C>T (p.Gln164Ter) SNV Likely pathogenic 41185 rs104895073 GRCh37: 11:67257530-67257530
GRCh38: 11:67490059-67490059
36 AIP NM_003977.4(AIP):c.500del (p.Pro167fs) Deletion Likely pathogenic 41186 rs267606557 GRCh37: 11:67257538-67257538
GRCh38: 11:67490067-67490067
37 AIP NM_003977.4(AIP):c.521_525del (p.Glu174fs) Deletion Likely pathogenic 41187 rs267606558 GRCh37: 11:67257557-67257561
GRCh38: 11:67490086-67490090
38 AIP NM_003977.4(AIP):c.550C>T (p.Gln184Ter) SNV Likely pathogenic 41188 rs267606560 GRCh37: 11:67257590-67257590
GRCh38: 11:67490119-67490119
39 AIP NM_003977.4(AIP):c.601A>T (p.Lys201Ter) SNV Likely pathogenic 41191 rs267606563 GRCh37: 11:67257641-67257641
GRCh38: 11:67490170-67490170
40 AIP NM_003977.4(AIP):c.646G>T (p.Glu216Ter) SNV Likely pathogenic 41193 rs267606565 GRCh37: 11:67257787-67257787
GRCh38: 11:67490316-67490316
41 AIP NM_003977.4(AIP):c.649C>T (p.Gln217Ter) SNV Likely pathogenic 41194 rs267606566 GRCh37: 11:67257790-67257790
GRCh38: 11:67490319-67490319
42 AIP NM_003977.4(AIP):c.662dup (p.Pro221_Glu222insTer) Duplication Likely pathogenic 41195 rs104895075 GRCh37: 11:67257799-67257800
GRCh38: 11:67490328-67490329
43 AIP NM_003977.4(AIP):c.70G>T (p.Glu24Ter) SNV Likely pathogenic 41196 rs267606568 GRCh37: 11:67250699-67250699
GRCh38: 11:67483228-67483228
44 AIP NM_003977.4(AIP):c.713G>A (p.Cys238Tyr) SNV Likely pathogenic 41197 rs267606569 GRCh37: 11:67257854-67257854
GRCh38: 11:67490383-67490383
45 MEN1 NM_001370259.2(MEN1):c.*412G>A SNV Likely pathogenic 446503 rs972128957 GRCh37: 11:64571394-64571394
GRCh38: 11:64803922-64803922
46 MEN1 NM_001370259.2(MEN1):c.*470A>G SNV Likely pathogenic 305302 rs778272737 GRCh37: 11:64571336-64571336
GRCh38: 11:64803864-64803864
47 AIP NM_003977.4(AIP):c.829G>C (p.Ala277Pro) SNV Likely pathogenic 41212 rs267606581 GRCh37: 11:67258300-67258300
GRCh38: 11:67490829-67490829
48 AIP NM_003977.4(AIP):c.854_857del (p.Gln285fs) Deletion Likely pathogenic 41213 rs267606582 GRCh37: 11:67258324-67258327
GRCh38: 11:67490853-67490856
49 AIP NM_003977.4(AIP):c.919dup (p.Arg307fs) Duplication Likely pathogenic 41215 rs267606589 GRCh37: 11:67258389-67258390
GRCh38: 11:67490918-67490919
50 AIP NM_003977.4(AIP):c.878_879delinsGT (p.Glu293Gly) Indel Likely pathogenic 242673 rs267606583 GRCh37: 11:67258349-67258350
GRCh38: 11:67490878-67490879

Expression for Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for Growth Hormone Secreting Pituitary Adenoma

GO Terms for Growth Hormone Secreting Pituitary Adenoma

Cellular components related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 SST SERPINB9 PRL POMC MIR423 MIR21

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.24 SSTR5 SSTR2 PRL POMC IGF1 GPR101
2 positive regulation of cell proliferation GO:0008284 10.05 PRL MIR21 IGF1 GHRHR GHRH
3 negative regulation of cell proliferation GO:0008285 10.02 SSTR5 SSTR2 SST MIR21 MEN1
4 neuropeptide signaling pathway GO:0007218 9.83 SSTR5 SSTR2 POMC
5 female pregnancy GO:0007565 9.82 PRL GNAS GHSR
6 negative regulation of angiogenesis GO:0016525 9.81 PRL MIR21 MIR185 GHRL
7 positive regulation of osteoblast differentiation GO:0045669 9.8 MIR21 IGF1 GNAS
8 negative regulation of interleukin-1 beta production GO:0032691 9.75 IGF1 GHSR GHRL
9 negative regulation of endothelial cell proliferation GO:0001937 9.7 PRL MIR21 GHRL
10 negative regulation of tumor necrosis factor production GO:0032720 9.67 POMC IGF1 GHSR GHRL
11 regulation of protein kinase A signaling GO:0010738 9.65 PRKAR1A AIP
12 positive regulation of growth GO:0045927 9.64 GHSR GHRL
13 positive regulation of hormone secretion GO:0046887 9.64 GHRHR GHRH
14 adult feeding behavior GO:0008343 9.63 GHSR GHRL
15 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.63 MIR21 IGF1
16 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.61 GHSR GHRL
17 adenohypophysis development GO:0021984 9.61 GHRHR GHRH
18 decidualization GO:0046697 9.61 MEN1 GHSR GHRL
19 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.6 MIR21 IGF1
20 somatostatin signaling pathway GO:0038170 9.58 SSTR5 SSTR2
21 positive regulation of vascular endothelial cell proliferation GO:1905564 9.58 MIR21 GHSR GHRL
22 positive regulation of eating behavior GO:1904000 9.57 GHSR GHRL
23 regulation of transmission of nerve impulse GO:0051969 9.56 GHSR GHRL
24 positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046010 9.55 GHRL GHRHR
25 positive regulation of appetite GO:0032100 9.54 GHSR GHRL
26 positive regulation of growth hormone secretion GO:0060124 9.5 GHRL GHRHR GHRH
27 regulation of gastric motility GO:1905333 9.49 GHSR GHRL
28 positive regulation of small intestine smooth muscle contraction GO:1904349 9.48 GHSR GHRL
29 positive regulation of small intestinal transit GO:0120058 9.46 GHSR GHRL
30 positive regulation of multicellular organism growth GO:0040018 9.46 GHSR GHRL GHRHR GHRH
31 growth hormone secretion GO:0030252 9.43 GHSR GHRL GHRH
32 G protein-coupled receptor signaling pathway GO:0007186 9.36 SSTR5 SSTR2 SST POMC KISS1 GPR101
33 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.26 IGF1 GHSR GHRHR GHRH

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.5 POMC GNAS GHRL
2 insulin-like growth factor receptor binding GO:0005159 9.37 IGF1 GNAS
3 somatostatin receptor activity GO:0004994 9.26 SSTR5 SSTR2
4 growth hormone-releasing hormone receptor activity GO:0016520 9.16 GHSR GHRHR
5 hormone activity GO:0005179 9.1 SST PRL POMC IGF1 GHRL GHRH
6 growth hormone-releasing hormone activity GO:0016608 8.96 GHRL GHRH

Sources for Growth Hormone Secreting Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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