MCID: GRW001
MIFTS: 40

Growth Hormone Secreting Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Genetic diseases

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

MalaCards integrated aliases for Growth Hormone Secreting Pituitary Adenoma:

Name: Growth Hormone Secreting Pituitary Adenoma 12 15
Growth Hormone-Secreting Pituitary Adenoma 43 17 71
Growth Hormone Producing Adenoma of the Pituitary 12
Growth Hormone Secreting Adenoma of Pituitary 12
Somatotroph Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6255
MeSH 43 D049912
NCIt 49 C7461
SNOMED-CT 67 254957009
UMLS 71 C0346302

Summaries for Growth Hormone Secreting Pituitary Adenoma

MalaCards based summary : Growth Hormone Secreting Pituitary Adenoma, also known as growth hormone-secreting pituitary adenoma, is related to galactorrhea and insulin-like growth factor i. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs lanreotide and Hormones have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and thyroid, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

Diseases in the Growth Hormone Secreting Pituitary Adenoma family:

Pituitary Adenoma 2, Growth Hormone-Secreting

Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 222)
# Related Disease Score Top Affiliating Genes
1 galactorrhea 30.9 PRL IGF1
2 insulin-like growth factor i 30.6 PRL IGF1 GHRH
3 hyperparathyroidism 30.3 PRKAR1A MEN1 IGF1
4 goiter 30.2 SST PRL IGF1 GNAS
5 tsh producing pituitary tumor 30.1 SSTR5 SSTR2 SST PRL
6 parathyroid adenoma 30.0 PRKAR1A MEN1 IGF1 GNAS
7 gigantism 29.9 PRL GPR101 GHRH AIP
8 lentigines 29.9 PRKAR1A POMC MEN1
9 gangliocytoma 29.8 PRL POMC GHRH
10 pituitary adenoma 1, multiple types 29.7 SST PRL MEN1 IGF1 AIP
11 fibrous dysplasia 29.7 SST PRL IGF1 GNAS GHRH
12 empty sella syndrome 29.7 PRL POMC IGF1
13 islet cell tumor 29.4 SSTR2 SST MEN1 IGF1 GHRH
14 amenorrhea 29.4 PRL POMC IGF1 GHRL
15 hypopituitarism 29.4 PRL POMC IGF1 GHRHR GHRH
16 mccune-albright syndrome 29.3 SST PRL PRKAR1A MEN1 IGF1 GPR101
17 primary hyperparathyroidism 29.1 PRL PRKAR1A POMC MEN1 IGF1
18 pituitary hormone deficiency, combined, 2 29.1 PRL POMC IGF1 GHRHR GHRH
19 hyperprolactinemia 29.1 SST PRL POMC IGF1 GNAS GHRH
20 hyperthyroidism 28.9 SST PRL POMC IGF1 GNAS GHRL
21 pituitary tumors 28.9 SSTR5 SST PRL POMC MEN1 IGF1
22 neuroendocrine tumor 28.7 SSTR2 SST POMC MEN1 GHRL GHRH
23 meningioma, familial 28.5 SSTR5 SSTR2 SST PRL PRKAR1A POMC
24 hypothyroidism 28.4 SST PRL POMC IGF1 GNAS GHRL
25 acromegaly 28.2 SSTR5 SSTR2 SST PRL PRKAR1A POMC
26 adenoma 27.8 SSTR5 SSTR2 SST PRL PRKAR1A POMC
27 pituitary adenoma, prolactin-secreting 27.2 SSTR5 SSTR2 SST PRL PRKAR1A POMC
28 carney complex variant 27.0 SST PRL PRKAR1A POMC MEN1 IGF1
29 multiple endocrine neoplasia, type i 26.9 SST PRL PRKAR1A POMC MEN1 GPR101
30 pituitary adenoma 26.7 SSTR5 SSTR2 SST PRL PRKAR1A POMC
31 hormone producing pituitary cancer 26.4 SSTR5 SSTR2 SST PRL PRKAR1A POMC
32 functioning pituitary adenoma 26.2 SSTR5 SSTR2 SST PRL PRKAR1A POMC
33 pituitary adenoma 2, growth hormone-secreting 11.7
34 fibrous dysplasia/mccune-albright syndrome 10.5 PRL GNAS
35 diabetes insipidus 10.5
36 breast ductal adenoma 10.5 PRL PRKAR1A
37 gastrointestinal neuroendocrine benign tumor 10.5 SST MEN1
38 non-functioning pancreatic endocrine tumor 10.4 SST MEN1
39 type c thymoma 10.4 SSTR2 SST
40 gastric neuroendocrine neoplasm 10.4 SST MEN1
41 abnormality of glucagon secretion 10.4 SST GHRL
42 duodenal gastrinoma 10.4 SST MEN1
43 breast adenoma 10.4 PRL PRKAR1A
44 pancreatic gastrinoma 10.4 SST MEN1
45 idiopathic gastroparesis 10.4 GHSR GHRL
46 null pituitary adenoma 10.4 MEN1 AIP
47 silent pituitary adenoma 10.4 MEN1 AIP
48 acth-independent cushing syndrome 10.4 PRKAR1A GNAS
49 spinocerebellar degeneration 10.4 SST PRL
50 duodenal somatostatinoma 10.4 SST MEN1

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to Growth Hormone Secreting Pituitary Adenoma

Symptoms & Phenotypes for Growth Hormone Secreting Pituitary Adenoma

MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.22 GHRH GHRHR GHRL GHSR GNAS POMC
2 homeostasis/metabolism MP:0005376 10.22 AIP GHRH GHRHR GHRL GHSR GNAS
3 endocrine/exocrine gland MP:0005379 10.18 AIP GHRH GHRHR GHRL GNAS IGF1
4 adipose tissue MP:0005375 10.15 GHRH GHRHR GHRL GHSR GNAS IGF1
5 growth/size/body region MP:0005378 10.15 AIP GHRH GHRHR GHSR GNAS IGF1
6 cardiovascular system MP:0005385 10.11 AIP GHRHR GNAS GPR101 IGF1 MEN1
7 digestive/alimentary MP:0005381 9.98 GHRL GHSR KISS1 MEN1 PRKAR1A SST
8 integument MP:0010771 9.86 AIP GHRHR GNAS IGF1 KISS1 POMC
9 liver/biliary system MP:0005370 9.76 AIP GHRH GNAS KISS1 MEN1 POMC
10 neoplasm MP:0002006 9.5 AIP GNAS IGF1 MEN1 POMC PRKAR1A
11 nervous system MP:0003631 9.32 GHRH GHRHR GNAS IGF1 KISS1 MEN1

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

Drugs for Growth Hormone Secreting Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
lanreotide Approved Phase 3 108736-35-2
2 Hormones Phase 3
3 Angiopeptin Phase 3
4 Pharmaceutical Solutions Phase 3
5
Sodium citrate Approved, Investigational Phase 2 68-04-2
6
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
7
Enclomiphene Investigational Phase 2 15690-57-0
8 Hormone Antagonists Phase 2
9 Citrate Phase 2
10 Estrogen Antagonists Phase 2
11 Estrogen Receptor Antagonists Phase 2
12 Clomiphene Phase 2
13 Estrogen Receptor Modulators Phase 2
14 Estrogens Phase 2
15 Zuclomiphene Phase 2
16
Rosiglitazone Approved, Investigational 122320-73-4 77999
17
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
18
Octreotide Approved, Investigational 83150-76-9 383414 6400441
19
gastric inhibitory polypeptide Investigational 100040-31-1
20 Hypoglycemic Agents
21 Antineoplastic Agents, Hormonal
22 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma From an Endocrinological Point of View (MERGE Study): a Randomized, Phase 3 Trial Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
2 Clomiphene Citrate for Treatment of Acromegaly Not Controlled by Conventional Therapies Completed NCT02274311 Phase 2 Clomiphene Citrate
3 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Unknown status NCT03309319 Rosiglitazone
4 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332
5 Characteristics of Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
6 Multicenter, Randomised Open Trial Comparing the Efficacy of a Medical Treatment With Sandostatin LP 30 mg Performed Before Surgery to a Prime Line transsphenoïdal Surgery in Previously Untreated Acromegalic Patients With Either a Micro or a Macro Pituitary Adenoma Completed NCT01029275 Pre-treatment with octreotide
7 Modulating the Glucose-dependent Insulinotropic Polypeptide (GIP) System in Patients With Acromegaly Due to a Pituitary Tumor Recruiting NCT03807076
8 Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA Recruiting NCT00461188

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Cochrane evidence based reviews: growth hormone-secreting pituitary adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

40
Pituitary, Bone, Thyroid, Colon, Skin

Publications for Growth Hormone Secreting Pituitary Adenoma

Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50) (show all 125)
# Title Authors PMID Year
1
Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development. 61
32389802 2020
2
Large-scale second-hit AIP deletion causing a pediatric growth hormone-secreting pituitary adenoma: Case report and review of literature. 61
32336638 2020
3
Acromegaly in preadolescence: A case report of a 9-year-old boy with acromegaly. 61
32363056 2020
4
Exosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly. 61
31469974 2020
5
Risk of internal carotid artery stenosis or occlusion after single-fraction radiosurgery for benign parasellar tumors. 61
31653808 2019
6
Simultaneous diagnosis of glioblastoma, cervical schwannoma, adrenal masses and growth hormone-secreting adenoma in a previously healthy patient. 61
31439570 2019
7
Internal carotid artery aneurysms diagnosed after stereotactic radiosurgery for a growth hormone-secreting pituitary adenoma: a case report and literature review. 61
30955084 2019
8
Benzene affects the response to octreotide treatment of growth hormone secreting pituitary adenoma cells. 61
30986651 2019
9
Association between KISS1 rs5780218 promoter polymorphism and onset of growth hormone secreting pituitary adenoma. 61
30318257 2019
10
Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study. 61
29757421 2019
11
Super Giant Growth Hormone-Secreting Pituitary Adenoma in Young Woman: From Ventricles to Nose. 61
30472284 2019
12
Carney Complex. 61
30428497 2019
13
Delayed Remission of Growth Hormone-Secreting Pituitary Adenoma After Transsphenoidal Adenectomy. 61
30447463 2019
14
Role and mechanisms of a three-dimensional bioprinted microtissue model in promoting proliferation and invasion of growth-hormone-secreting pituitary adenoma cells. 61
30537696 2019
15
Incidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study. 61
30643415 2019
16
Inoperable Giant Growth Hormone-secreting Pituitary Adenoma: Radiological Aspects, Clinical Management and Pregnancy Outcome. 61
30088454 2019
17
Head and neck manifestations of an undiagnosed McCune-Albright syndrome: clinicopathological description and literature review. 61
29984378 2018
18
Adenoma size and postoperative IGF-1 levels predict surgical outcomes in acromegaly patients: results of the Swiss Pituitary Registry (SwissPit). 61
30141524 2018
19
Top 100 Most-Cited Articles on Pituitary Adenoma: A Bibliometric Analysis. 61
29870843 2018
20
Quantification of specific growth patterns and frequency of the empty sella phenomenon in growth hormone-secreting pituitary adenomas. 61
29857870 2018
21
Three-dimensional speckle tracking echocardiography-derived left atrial deformation analysis in acromegaly (Results from the MAGYAR-Path Study). 61
29569265 2018
22
Oro-dental pathologies in acromegaly. 61
29520625 2018
23
Left ventricular twist is impaired in acromegaly: Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study. 61
28990677 2018
24
Establishment of a protocol to extend the lifespan of human hormone-secreting pituitary adenoma cells. 61
28447256 2018
25
Collision tumors composed of meningioma and growth hormone-secreting pituitary adenoma in the sellar region: Case reports and a literature review. 61
29390316 2017
26
Surgical Outcome of Growth Hormone-Secreting Pituitary Adenoma with Empty Sella Using a New Classification. 61
28642181 2017
27
EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway. 61
28705113 2017
28
A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management. 61
28279554 2017
29
Metformin inhibits proliferation and growth hormone secretion of GH3 pituitary adenoma cells. 61
28380462 2017
30
Granulomatous hypophysitis caused by Rathke's cleft cyst mimicking a growth hormone-secreting pituitary adenoma. 61
28484553 2017
31
Toward the next step in G protein-coupled receptor research: a knowledge-driven analysis for the next potential targets in drug discovery. 61
28063110 2016
32
The use of intraoperative computed tomography navigation in pituitary surgery promises a better intraoperative orientation in special cases. 61
27695249 2016
33
Growth hormone secreting pituitary adenoma with admixed gangliocytoma and ganglioglioma. 61
27068013 2016
34
Carney complex: A familial lentiginosis predisposing to a variety of tumors. 61
27943004 2016
35
In vitro impact of pegvisomant on growth hormone-secreting pituitary adenoma cells. 61
27267119 2016
36
Long-term results of hypofractionated stereotactic radiotherapy with CyberKnife for growth hormone-secreting pituitary adenoma: evaluation by the Cortina consensus. 61
26961771 2016
37
Exponentially growing osteosarcoma of mandible with acromegaly. 61
26879563 2016
38
Effect of Transsphenoidal Adenectomy on Glucose Tolerance Status in Patients with Growth Hormone-secreting Pituitary Adenoma. 61
26956860 2016
39
Expression of somatostatin receptor subtype 2 in growth hormone-secreting pituitary adenoma and the regulation of miR-185. 61
26036598 2015
40
Review of current and emerging treatment options in acromegaly. 61
26478545 2015
41
[Risk factors of obstructive sleep apnea hypopnea syndrome and sleep hypopnea in patients with growth hormone-secreting pituitary adenoma]. 61
26547350 2015
42
Acromegaly: otolaryngic manifestations following pituitary surgery. 61
25794787 2015
43
Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression. 61
25853400 2015
44
Surgical management of acromegaly in a resource-challenged environment. 61
25657502 2015
45
Multisession gamma knife radiosurgery: a preliminary experience with a noninvasive, relocatable frame. 61
25088232 2014
46
Endoscopic Decompression for Optic Neuropathy in McCune-Albright Syndrome. 61
25368777 2014
47
A missed diagnosis of acromegaly during a female-to-male gender transition. 61
24867179 2014
48
Gigantism caused by growth hormone secreting pituitary adenoma. 61
25077093 2014
49
Long-term changes in serum IGF-1 levels after successful surgical treatment of growth hormone-secreting pituitary adenoma. 61
23728452 2013
50
Undifferentiated sarcoma of the cavernous sinus after γ knife radiosurgery for pituitary adenoma. 61
23587603 2013

Variations for Growth Hormone Secreting Pituitary Adenoma

Expression for Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for Growth Hormone Secreting Pituitary Adenoma

GO Terms for Growth Hormone Secreting Pituitary Adenoma

Cellular components related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.35 SSTR5 SSTR2 KISS1 GHSR GHRH
2 extracellular space GO:0005615 9.28 SST PRL POMC MIR423 MIR185 KISS1

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.07 SSTR5 SSTR2 PRL POMC IGF1 GPR101
2 negative regulation of cell proliferation GO:0008285 9.97 SSTR5 SSTR2 SST MEN1 KISS1
3 cell-cell signaling GO:0007267 9.91 SST POMC GPR101 GHRH
4 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.82 GNAS GHRHR GHRH
5 neuropeptide signaling pathway GO:0007218 9.81 SSTR5 SSTR2 POMC
6 female pregnancy GO:0007565 9.8 PRL GNAS GHSR
7 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.77 GPR101 GNAS GHRHR
8 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.65 GHSR GHRL
9 negative regulation of tumor necrosis factor secretion GO:1904468 9.64 GHSR GHRL
10 regulation of protein kinase A signaling GO:0010738 9.64 PRKAR1A AIP
11 positive regulation of growth GO:0045927 9.62 GHSR GHRL
12 adult feeding behavior GO:0008343 9.62 GHSR GHRL
13 positive regulation of multicellular organism growth GO:0040018 9.62 GHSR GHRL GHRHR GHRH
14 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.61 GHSR GHRL
15 decidualization GO:0046697 9.61 MEN1 GHSR GHRL
16 positive regulation of hormone secretion GO:0046887 9.6 GHRHR GHRH
17 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.58 GHSR GHRL
18 adenohypophysis development GO:0021984 9.58 GHRHR GHRH
19 negative regulation of interleukin-1 beta production GO:0032691 9.58 IGF1 GHSR GHRL
20 somatostatin signaling pathway GO:0038170 9.56 SSTR5 SSTR2
21 positive regulation of eating behavior GO:1904000 9.55 GHSR GHRL
22 regulation of transmission of nerve impulse GO:0051969 9.54 GHSR GHRL
23 positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046010 9.52 GHRL GHRHR
24 positive regulation of appetite GO:0032100 9.51 GHSR GHRL
25 regulation of gastric motility GO:1905333 9.49 GHSR GHRL
26 positive regulation of small intestine smooth muscle contraction GO:1904349 9.48 GHSR GHRL
27 positive regulation of small intestinal transit GO:0120058 9.46 GHSR GHRL
28 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.46 IGF1 GHSR GHRHR GHRH
29 growth hormone secretion GO:0030252 9.43 GHSR GHRL GHRH
30 G protein-coupled receptor signaling pathway GO:0007186 9.36 SSTR5 SSTR2 SST POMC KISS1 GPR101
31 positive regulation of growth hormone secretion GO:0060124 9.26 KISS1 GHRL GHRHR GHRH

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.5 POMC GNAS GHRL
2 insulin-like growth factor receptor binding GO:0005159 9.37 IGF1 GNAS
3 somatostatin receptor activity GO:0004994 9.26 SSTR5 SSTR2
4 growth hormone-releasing hormone receptor activity GO:0016520 9.16 GHSR GHRHR
5 hormone activity GO:0005179 9.1 SST PRL POMC IGF1 GHRL GHRH
6 growth hormone-releasing hormone activity GO:0016608 8.96 GHRL GHRH

Sources for Growth Hormone Secreting Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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