Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
GBS
MCID: GLL022
MIFTS: 63

Guillain-Barre Syndrome (GBS)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Guillain-Barre Syndrome

About this section

MalaCards integrated aliases for Guillain-Barre Syndrome:

Name: Guillain-Barre Syndrome 12 53 25 37 55 43 44 15 73
Guillain-Barré Syndrome 53 25 54 3
Fisher Syndrome 25 54 37
Acute Inflammatory Demyelinating Polyneuropathy 53 73
Acute Inflammatory Polyneuropathy 53 25
Gbs 53 25
Acute Inflammatory Demyelinating Polyradiculoneuropathy 53
Acute Autoimmune Peripheral Neuropathy 53
Landry-Guillain-Barre-Strohl Syndrome 53
Acute Immune-Mediated Polyneuropathy 53
Acute Postinfectious Polyneuropathy 12
Guillain-Barré-Strohl Syndrome 53
Landry-Guillain-Barre Syndrome 25
Acute Inflammatory Neuropathy 53
Acute Infectious Polyneuritis 25
Acute Infective Polyneuritis 12
Post-Infectious Polyneuritis 12
Landry's Ascending Paralysis 53
Postinfectious Polyneuritis 12
Post-Infective Polyneuritis 53
Miller Fisher Syndrome 73
Guillainbarr� Syndrome 76
Infectious Neuronitis 12

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Infectious diseases
Anatomical: Immune diseases Neuronal diseases Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:12842
ICD10 33 G61.0
MeSH 44 D020275
NCIt 50 C116345
SNOMED-CT 68 40956001
Sources

Summaries for Guillain-Barre Syndrome

About this section
MedlinePlus : 43 Guillain-Barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (PNS). The PNS nerves connect your brain and spinal cord with the rest of your body. Damage to these nerves makes it hard for them to transmit signals. As a result, your muscles have trouble responding to your brain. No one knows what causes the syndrome. Sometimes it is triggered by an infection, surgery, or a vaccination. The first symptom is usually weakness or a tingling feeling in your legs. The feeling can spread to your upper body. In severe cases, you become almost paralyzed. This is life-threatening. You might need a respirator to breathe. Symptoms usually worsen over a period of weeks and then stabilize. Guillain-Barre can be hard to diagnose. Possible tests include nerve tests and a spinal tap. Most people recover. Recovery can take a few weeks to a few years. Treatment can help symptoms, and may include medicines or a procedure called plasma exchange. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Guillain-Barre Syndrome, also known as guillain-barré syndrome, is related to miller fisher syndrome and peripheral nervous system disease, and has symptoms including seizures, tremor and back pain. An important gene associated with Guillain-Barre Syndrome is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Allograft rejection. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Genetics Home Reference : 25 Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.

NIH Rare Diseases : 53 Guillain-Barré syndrome (GBS) is a rare syndrome in which the body�??s immune system attacks part of the peripheral nervous system. The peripheral nervous system carries signals from the brain to the muscles. Symptoms of GBS include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all (paralysis). The exact cause of Guillain-Barré syndrome is unknown. In most cases, GBS occurs a few days or weeks after symptoms of a viral infection. In rare cases, GBS may run in families. A diagnosis of GBS is suspected when a person has symptoms suggestive of the syndrome. A variety of tests, including a spinal tap, may be completed to confirm the diagnosis. Treatment options may include plasma exchange (plasmapheresis) and immunoglobulin therapy. 

CDC : 3 Guillain-Barré syndrome (GBS) is a rare disorder where the body’s immune system damages nerve cells, causing muscle weakness and sometimes paralysis. While its cause is not fully understood, the syndrome often follows infection with a virus or bacteria. In the United States, an estimated 3,000 to 6,000 people develop GBS each year. Most people recover fully from GBS, but some have permanent nerve damage.

NINDS : 54 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Wikipedia : 76 Guillain�??Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging... more...

Sources

Related Diseases for Guillain-Barre Syndrome

About this section

Diseases in the Guillain-Barre Syndrome family:

Guillain-Barre Syndrome, Familial

Diseases related to Guillain-Barre Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 miller fisher syndrome 33.7 HMGA2 TNF
2 peripheral nervous system disease 32.0 ALB MBP MPZ PMP22 TNF
3 polyneuropathy 30.8 MBP MPZ PMP22
4 viral hepatitis 30.6 ALB FAS TNF
5 demyelinating polyneuropathy 30.5 ALB HP PMP22
6 demyelinating disease 30.5 MBP TNF TNFRSF1A
7 pustulosis of palm and sole 30.4 TNF TNFRSF1B
8 chronic inflammatory demyelinating polyradiculoneuropathy 30.2 ALB MPZ PMP22
9 optic neuritis 30.2 MBP MPZ TNF
10 immunoglobulin alpha deficiency 30.1 CD79A HLA-DQB1 HP
11 acute disseminated encephalomyelitis 30.1 HCRT HLA-DQB1 MBP MPZ
12 meningoencephalitis 30.1 ALB CD79A MBP
13 cytomegalovirus infection 30.0 FAS TNF TNFRSF1A
14 neuritis 30.0 MBP MPZ PMP2 PMP22 TNF
15 polyradiculoneuropathy 30.0 ALB MBP MPZ PMP2 PMP22
16 pelizaeus-merzbacher disease 30.0 MBP MPZ PMP22
17 type ii mixed cryoglobulinemia 29.9 FAS HLA-DQB1
18 charcot-marie-tooth disease 29.8 MBP MPZ PMP2 PMP22
19 multiple sclerosis 29.8 HLA-DQB1 MBP MPZ TNF TNFRSF1A
20 celiac disease 1 29.7 ALB CD79A HLA-DQB1 HP TNF
21 systemic lupus erythematosus 29.7 ALB CD79A FAS HLA-DQB1 TNF TNFRSF1A
22 liver disease 29.6 ALB FAS TNF TNFRSF1A
23 guillain-barre syndrome, familial 12.8
24 kozlowski warren fisher syndrome 12.1
25 chronic inflammatory demyelinating polyneuropathy 11.8
26 dysautonomia 11.7
27 zika virus infection 11.6
28 acute flaccid myelitis 11.5
29 chronic polyradiculoneuritis 11.4
30 combined immunodeficiency with skin granulomas 11.4
31 lewis-sumner syndrome 11.4
32 thyrotoxic periodic paralysis 11.4
33 neuropathy, hereditary sensory and autonomic, type iii 11.3
34 facial diplegia with paresthesias 11.0
35 bickerstaff brainstem encephalitis 10.9
36 acute motor axonal neuropathy 10.9
37 herpes simplex 10.5
38 acute pandysautonomia 10.5
39 acute sensory ataxic neuropathy 10.5
40 paraparetic variant of guillain-barré syndrome 10.5
41 acute pure sensory neuropathy 10.5
42 pharyngeal-cervical-brachial variant of guillain-barré syndrome 10.5
43 acute motor and sensory axonal neuropathy 10.5
44 influenza 10.4
45 welander distal myopathy 10.4
46 hepatitis 10.4
47 neuropathy 10.4
48 arthritis 10.3
49 reactive arthritis 10.3
50 encephalitis 10.3

Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to Guillain-Barre Syndrome
Sources

Symptoms & Phenotypes for Guillain-Barre Syndrome

About this section

UMLS symptoms related to Guillain-Barre Syndrome:


seizures, tremor, back pain, pain, headache, ophthalmoplegia, syncope, chronic pain, sciatica, cerebellar ataxia, vertigo/dizziness, sleeplessness, neuralgia

GenomeRNAi Phenotypes related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 CD79A HLA-DQB1 MPZ
2 Decreased viability GR00381-A-3 9.28 CD79A HLA-DQB1 MPZ
3 Decreased viability GR00402-S-2 9.28 CD79A HLA-DQB1 MPZ

MGI Mouse Phenotypes related to Guillain-Barre Syndrome:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ALB CD79A DAAM2 FAS HCRT HLA-DQB1
2 cellular MP:0005384 10.2 ALB CD79A FAS HLA-DQB1 HP MBP
3 behavior/neurological MP:0005386 10.19 FAS HCRT HLA-DQB1 MBP MPZ PMP2
4 hematopoietic system MP:0005397 10.09 CD79A FAS HLA-DQB1 HP MBP MPZ
5 cardiovascular system MP:0005385 10.08 DAAM2 FAS HCRT HLA-DQB1 HP TNF
6 immune system MP:0005387 10.02 CD79A FAS HLA-DQB1 HP MBP MPZ
7 liver/biliary system MP:0005370 9.92 ALB CD79A FAS HLA-DQB1 HP TNF
8 muscle MP:0005369 9.86 ALB DAAM2 HCRT HLA-DQB1 PMP22 TNF
9 neoplasm MP:0002006 9.7 ALB CD79A FAS HP TNF TNFRSF1A
10 nervous system MP:0003631 9.7 CD79A FAS HCRT HLA-DQB1 MBP MPZ
11 renal/urinary system MP:0005367 9.17 ALB CD79A FAS HLA-DQB1 HP TNFRSF1A
Sources

Drugs & Therapeutics for Guillain-Barre Syndrome

About this section

Drugs for Guillain-Barre Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4,Phase 3,Phase 2,Not Applicable
2 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
3
Pembrolizumab Approved Phase 3 1374853-91-4
4 Immunoglobulins Phase 3,Phase 2,Not Applicable
5 Antibodies Phase 3,Phase 2,Not Applicable
6
4-Aminopyridine Approved Phase 2 504-24-5 1727
7
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
8
Lactitol Investigational Phase 2 585-86-4 3871
9 Complement System Proteins Phase 2
10 Pharmaceutical Solutions Phase 2
11 Immunoglobulins, Intravenous Phase 2,Not Applicable
12 gamma-Globulins Phase 2,Not Applicable
13 Rho(D) Immune Globulin Phase 2,Not Applicable
14 Potassium Channel Blockers Phase 2
15 MF59 oil emulsion Phase 2
16 Antineoplastic Agents, Hormonal Phase 2
17 Anti-Inflammatory Agents Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 glucocorticoids Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
22 Hemagglutinins Phase 2
23
Infliximab Approved 170277-31-3
24
Nivolumab Approved 946414-94-4
25
Thiamine Approved, Investigational, Nutraceutical, Vet_approved 59-43-8, 70-16-6 1130
26
Citric Acid Approved, Nutraceutical, Vet_approved Not Applicable 77-92-9 311
27 Vitamin B Complex
28 Thiamin
29 Vitamins
30 Calcium, Dietary Not Applicable
31 Anticoagulants Not Applicable
32 Citrate Not Applicable
33 Chelating Agents Not Applicable
34 Gastrointestinal Agents
35 Dermatologic Agents
36 Antirheumatic Agents
37 Immunoglobulin G
38 Autoantibodies

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 A Study of Fluzone® High-Dose Vaccine Compared With Fluzone® Vaccine In Elderly Adults Completed NCT01427309 Phase 4
2 Efficacy and Safety Study of GB-0998 for Guillain-Barré Syndrome Completed NCT02342184 Phase 3 GB-0998
3 Phase III Clinical Trial of NPB-01 in Patients With Guillain-Barré Syndrome Completed NCT02221271 Phase 3 NPB-01
4 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
5 Study to Evaluate the Long-term Antibody Persistence of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine (GSK134612) Versus Mencevax ACWY in Healthy Adolescents and Adults and Booster Response to MenACWY-TT Vaccine Administered at 10 Years Post-primary Vaccination Completed NCT01934140 Phase 3
6 Extension Study of Maintenance Treatment With Subcutaneous Immunoglobulin (IgPro20) for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Completed NCT02027701 Phase 3
7 A Study To Evaluate A Booster Dose Of Menacwy-tt Vaccine Administered 10 Years After Healthy Subjects Aged 11-17 Years Received Either Menacwy-tt Vaccine (Nimenrix(Registered)) Or Mencevax Acwy(Registered). Completed NCT03189745 Phase 3
8 Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) Recruiting NCT03486873 Phase 3 Standard of Care (SOC)
9 Multi-Year Study of Fluzone High-Dose Influenza Vaccine Compared With Fluzone® Vaccine in Adults Aged 65 Years and Older Terminated NCT00976027 Phase 3
10 Inhibition of Complement Activation (Eculizumab) in Guillain-Barre Syndrome Study Unknown status NCT02029378 Phase 2 Eculizumab
11 Small Volume Plasma Exchange (SVPE) for Guillain-Barré Syndrome (GBS) Patients Completed NCT02780570 Phase 2
12 Early Mechanical Ventilation for Guillain Barré Syndrome Completed NCT00167622 Phase 2
13 Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine Completed NCT00056810 Phase 2 4-aminopyridine (4-AP)
14 JET-GBS - Japanese Eculizumab Trial for GBS Completed NCT02493725 Phase 2 Eculizumab;Placebo
15 Immunomodulatory Effects of IVIg on Pregnancy Rate of Patient With Recurrent Implantation Failure Completed NCT03174964 Phase 2 IVIg
16 Seasonal Flu Vaccine in Adult Transplant Recipients Completed NCT01258023 Phase 2
17 Prednisone Treatment for Vestibular Neuronitis Completed NCT00271791 Phase 2 Prednisone;Prednisone
18 Sanofi H1N1 + TIV - Adults and Elderly Completed NCT00943878 Phase 2 Placebo
19 Novartis H1N1 Vaccine in Pregnant Women Completed NCT00992719 Phase 2
20 2010-2011 Trivalent Influenza Vaccine (TIV) in Pregnant Women Completed NCT01173211 Phase 2
21 Sanofi H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations Completed NCT00963157 Phase 2 AS03
22 H1N1 Vaccine at Two Dose Levels in HIV Positive Adults Completed NCT00992433 Phase 2
23 Sanofi Pasteur, TIV + H1N1, Pediatric Population Completed NCT00943202 Phase 2
24 H1N1 Vaccine in Pregnant Women Completed NCT00963430 Phase 2
25 Study of GLS-5700 in Dengue Virus Seropositive Adults Completed NCT02887482 Phase 1
26 Study of GLS-5700 in Healthy Volunteers Completed NCT02809443 Phase 1
27 A Clinical Trial of CK0801 (a New Drug) In Patients With Treatment-Resistant Guillain-Barré Syndrome (GBS) Not yet recruiting NCT03773328 Phase 1
28 International Guillain-Barré Syndrome Outcome Study Unknown status NCT01582763
29 sCD163 as a Potential Biomarker in Guillain- Barré Syndrome Unknown status NCT02582853
30 The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation Unknown status NCT00173199
31 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
32 Detection of Peripheral Blood Biomarkers in Intermediate Phase Spinal Cord Injury: Correlation With Neurological and Functional Outcomes, and Comparison to Other Central and Peripheral Neurological Conditions. Unknown status NCT01516385
33 Thiamin (Vitamin B1) Levels in Eating Disorder Adolescent Patients Unknown status NCT02164487
34 Perception and Multisensory Integration in Neurological Patients Using fMRI Unknown status NCT01469858 Not Applicable
35 Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS) Completed NCT01306578 Not Applicable IVIG
36 Safety Study of GBS Following Menactra Meningococcal Vaccination Completed NCT00575653
37 Effects of Robotic-assisted Gait Training In Non-Ambulatory Patients After Guillain-Barré Syndrome Completed NCT02883270 Not Applicable
38 Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome. Completed NCT01024088
39 Brain Computer Interface for Communication in ICU: a Feasibility Study Completed NCT01005524
40 Regional Citrate Anticoagulation in Plasma Exchange Treatment Completed NCT01370200 Not Applicable
41 Cervarix Long-term Safety Surveillance Completed NCT01498627
42 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
43 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997
44 Surveillance for Adverse Events Following Pandemic H1N1 Immunization Completed NCT01289418
45 Surveillance for Adverse Events Following Influenza Immunization Completed NCT01318876
46 Post-authorisation Passive Enhanced Safety Surveillance of Seasonal Influenza Vaccines Completed NCT02893878
47 Database Surveillance Safety Study of PENTACEL® Vaccine Completed NCT00804284
48 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
49 Postmarketing Safety Surveillance European Registry of Crohn's Disease Patients Treated With Remicade or Standard Therapy (MK-2155-035) Completed NCT00705614
50 Neurologic Manifestations of the Arbovirus Infection in Colombia Recruiting NCT03206541

Search NIH Clinical Center for Guillain-Barre Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: guillain-barre syndrome

Sources

Genetic Tests for Guillain-Barre Syndrome

About this section
Sources

Anatomical Context for Guillain-Barre Syndrome

About this section

MalaCards organs/tissues related to Guillain-Barre Syndrome:

41
Brain, Testes, Spinal Cord, Heart, Eye, Lung, B Cells
Sources

Publications for Guillain-Barre Syndrome

About this section

Articles related to Guillain-Barre Syndrome:

(show top 50) (show all 836)
# Title Authors Year
1
Case report: Guillain-Barre syndrome with pneumococcus - A new association in pediatrics. ( 29387550 )
2018
2
Post Vaccination Guillain Barre Syndrome: A Case Report. ( 29930889 )
2018
3
Motor Nerve Conduction Block Predicting Outcome of Guillain-Barre Syndrome. ( 29910770 )
2018
4
Epidemiology and Clinical Features of Guillain-Barre Syndrome in Isfahan, Iran. ( 29930927 )
2018
5
Guillain-Barre syndrome associated with hemorrhagic fever with renal syndrome in China: a case report. ( 29587642 )
2018
6
Characteristics, incidence and outcome of patients admitted to intensive care unit with Guillain-Barre syndrome in Australia and New Zealand. ( 29413724 )
2018
7
Guillain-Barre syndrome caused by hepatitis E infection: case report and literature review. ( 29357816 )
2018
8
Acute-onset Restless legs syndrome in acute neurological conditions-a prospective study on patients with the Guillain-Barre syndrome and acute stroke. ( 29359321 )
2018
9
Nivolumab-Associated Guillain-Barre Syndrome in a Patient With Non-Small-Cell Lung Cancer. ( 29889678 )
2018
10
Prospective comparison of acute motor axonal neuropathy and acute inflammatory demyelinating polyradiculoneuropathy in 140 children with Guillain-Barré syndrome in India. ( 29053890 )
2018
11
An overlapping case of Bickerstaff brainstem encephalitis and acute motor axonal neuropathy variant of Guillain-Barre syndrome associated with Systemic Lupus Erythematosus. ( 30444497 )
2018
12
Ischemic polyradiculoneuropathy with an aortic aneurysm masquerading Guillain-Barré syndrome. ( 30038123 )
2018
13
Miller Fisher syndrome, Bickerstaff brainstem encephalitis and Guillain-Barré syndrome overlap with persistent non-demyelinating conduction blocks: a case report. ( 30031375 )
2018
14
Overlap of Bickerstaff brainstem encephalitis/Guillain-Barré syndrome simulating brain death. ( 30233023 )
2018
15
Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barré syndrome in children: Report of two cases and review of the literature. ( 30502045 )
2018
16
Transverse Myelitis and Guillain-Barré Syndrome Associated with Cat-Scratch Disease, Texas, USA, 2011. ( 30124417 )
2018
17
Successful IVIG treatment without discontinuation of TNF-α blocker in Guillain-Barre syndrome induced by adalimumab in patient with Crohn's disease. ( 29101591 )
2018
18
First pathological report of a de novo CD5-positive diffuse large B-cell lymphoma patient presenting with Guillain-Barré syndrome-like neuropathy due to neurolymphomatosis. ( 29718563 )
2018
19
Erratum to 'Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity', Journal of the Neurological Sciences, Volume 395, 15 December 2018, Pages 47-53. ( 30401470 )
2018
20
Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika and multiple arboviral immunity. ( 30401491 )
2018
21
Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity. ( 30423542 )
2018
22
Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity. ( 30292020 )
2018
23
Bickerstaff's brainstem encephalitis with overlapping Guillain-Barré syndrome: Usefulness of sequential nerve conduction studies. ( 29459060 )
2018
24
Posterior Reversible Encephalopathy Syndrome and Guillain-Barré Syndrome after Head Injury: Case Report. ( 30078819 )
2018
25
Guillain-Barré Syndrome secondary to tacrolimus in a patient with corticoresistant nephrotic syndrome caused by focal and segmental glomerulonephritis and IgA nephropathy. ( 29246388 )
2018
26
Rare presentation of Guillain-Barre syndrome with complete heart block and neuropathic chest pain mimicking acute coronary syndrome: a case report ( 30415521 )
2018
27
The electrodiagnosis of Guillain-Barré syndrome subtypes: Where do we stand? ( 30419502 )
2018
28
Increased incidence of axonal Guillain-Barré syndrome in La Spezia area of Italy: A 13-year follow-up study. ( 30421471 )
2018
29
Guillain-Barré Syndrome and Low Back Pain: Two Cases and Literature Review. ( 30426088 )
2018
30
Guillain-Barré syndrome subtypes: A clinical electrophysiological study of 100 patients. ( 30442448 )
2018
31
Systematic review of factors associated with the development of guillain-barré syndrome 2007 to 2017: what has changed? ( 30444562 )
2018
32
The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain-Barré syndrome. ( 30464413 )
2018
33
Spontaneous spinal epidural hematoma mimicking Guillain-Barre Syndrome. ( 30471873 )
2018
34
Outcomes of patients with Guillain Barre Syndrome - Experience from a tertiary care hospital of a developing Asian country and review of regional literature. ( 30477890 )
2018
35
Guillain Barré syndrome in arbovirus outbreak, Campylobacter claims his throne. ( 30530283 )
2018
36
Simultaneous Occurrence of Axonal Guillain-Barré Syndrome in Two Siblings Following Dengue Infection. ( 30532365 )
2018
37
A Predictive Model for Guillain-Barré Syndrome Based on Ensemble Methods. ( 30532769 )
2018
38
Guillain-Barré syndrome in Denmark: a population-based study on epidemiology, diagnosis and clinical severity. ( 30536111 )
2018
39
NEUROMUSCULAR ELECTRICAL STIMULATION IN EARLY REHABILITATION OF GUILLAIN-BARRÉ SYNDROME: A PILOT STUDY. ( 30549053 )
2018
40
The Efficacy of Intravenous Immunoglobulin in Guillain-Barré Syndrome: The Experience of a Tertiary Medical Center. ( 30550005 )
2018
41
Pharyngeal-cervical-brachial variant of Guillain-Barré syndrome with predominant bulbar palsy and anti-GM3 IgG antibodies. ( 29455402 )
2018
42
Additional arguments supporting that Franklin Delano Roosevelt's paralytic illness was related to Guillain-Barré syndrome. ( 29461141 )
2018
43
Prolonged Zika virus viremia in a patient with Guillain-Barré syndrome in Trinidad and Tobago. ( 29466521 )
2018
44
Predictors of respiratory failure in patients with Guillain-Barré syndrome: a systematic review and meta-analysis. ( 29490222 )
2018
45
Headache in Guillain-Barré Syndrome: Diagnostic and Management Implications. ( 29506598 )
2018
46
Electrophysiologic lessons from the European multicenter study of Guillain-Barré syndrome subtype diagnosis. ( 29524332 )
2018
47
Guillain-Barré syndrome and hyponatraemia. ( 29526312 )
2018
48
Incidence of Guillain-Barré syndrome during the Zika virus outbreak. ( 29526321 )
2018
49
Guillain-Barré syndrome: rare extra-intestinal manifestation of hepatitis B. ( 29542024 )
2018
50
The Impact of Post-Genomics Approaches in Neurodegenerative Demyelinating Diseases: The Case of Guillain-Barré Syndrome. ( 29542408 )
2018
Sources

Variations for Guillain-Barre Syndrome

About this section
Sources

Expression for Guillain-Barre Syndrome

About this section
Search GEO for disease gene expression data for Guillain-Barre Syndrome.
Sources

Pathways for Guillain-Barre Syndrome

About this section

Pathways related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Development Angiotensin activation of ERK 22
Show member pathways
 12.73 CD79A FAS TNF TNFRSF1A TNFRSF1B
2
Allograft rejection 1 37
Show member pathways
 12.69 FAS HLA-DQB1 TNF TNFRSF1A TNFRSF1B
3
DREAM Repression and Dynorphin Expression 64
Show member pathways
 12.3 FAS TNF TNFRSF1A TNFRSF1B
4
Immune response NFAT in immune response 22
Show member pathways
 12.28 CD79A HLA-DQB1 TNF TNFRSF1A TNFRSF1B
5
TNF signaling (REACTOME) 1
Show member pathways
 12.13 FAS TNF TNFRSF1A TNFRSF1B
6
NF-kappaB Signaling 4
12.07 CD79A FAS TNF TNFRSF1A TNFRSF1B
7
Apoptosis and Autophagy 4
12.02 FAS TNF TNFRSF1A TNFRSF1B
8
Amyotrophic lateral sclerosis (ALS) 1 37
Show member pathways
 11.8 TNF TNFRSF1A TNFRSF1B
9
Neural Crest Differentiation 1
11.74 MBP MPZ PMP22
10
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.56 TNF TNFRSF1A TNFRSF1B
11
Adipocytokine signaling pathway 37
11.53 TNF TNFRSF1A TNFRSF1B
12
Transcription_NF-kB signaling pathway 22
11.39 TNF TNFRSF1A TNFRSF1B
13
Photodynamic therapy-induced AP-1 survival signaling. 1
11.32 FAS TNF TNFRSF1A
14
Cellular Transformation by HTLV1 64
Show member pathways
 11.28 TNF TNFRSF1A TNFRSF1B
15
Interleukin-10 signaling 66
11.23 TNF TNFRSF1A TNFRSF1B
16
Signal transduction_JNK pathway 22
11.08 FAS TNF TNFRSF1A
17
TNF signaling pathway 37
10.97 FAS TNF TNFRSF1A TNFRSF1B
18
Canonical NF-kappaB pathway 1
10.95 TNF TNFRSF1A
19
14-3-3 and Regulation of BAD Activity 64
10.64 TNF TNFRSF1A TNFRSF1B
Sources

GO Terms for Guillain-Barre Syndrome

About this section

Cellular components related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 9.46 ALB MBP MPZ PMP2
2 compact myelin GO:0043218 9.26 MBP PMP22
3 membrane raft GO:0045121 9.02 CD79A FAS TNF TNFRSF1A TNFRSF1B
4 tumor necrosis factor receptor superfamily complex GO:0002947 8.96 TNFRSF1A TNFRSF1B

Biological processes related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.88 FAS HLA-DQB1 MBP TNF TNFRSF1B
2 chemical synaptic transmission GO:0007268 9.84 HCRT MBP MPZ PMP22
3 defense response GO:0006952 9.74 HP TNF TNFRSF1A
4 tumor necrosis factor-mediated signaling pathway GO:0033209 9.67 TNF TNFRSF1A TNFRSF1B
5 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 TNF TNFRSF1A TNFRSF1B
6 negative regulation of cardiac muscle hypertrophy GO:0010614 9.56 TNFRSF1A TNFRSF1B
7 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 TNF TNFRSF1B
8 myelination GO:0042552 9.54 MBP MPZ PMP22
9 positive regulation of ceramide biosynthetic process GO:2000304 9.52 TNF TNFRSF1A
10 death-inducing signaling complex assembly GO:0071550 9.51 TNF TNFRSF1A
11 extrinsic apoptotic signaling pathway GO:0097191 9.5 FAS TNF TNFRSF1B
12 regulation of establishment of endothelial barrier GO:1903140 9.46 TNF TNFRSF1A
13 necroptotic signaling pathway GO:0097527 9.43 FAS TNF
14 aortic valve development GO:0003176 9.26 TNFRSF1A TNFRSF1B
15 negative regulation of extracellular matrix constituent secretion GO:0003332 9.16 TNFRSF1A TNFRSF1B
16 positive regulation of apoptotic process involved in morphogenesis GO:1902339 8.96 TNFRSF1A TNFRSF1B
17 pulmonary valve development GO:0003177 8.62 TNFRSF1A TNFRSF1B

Molecular functions related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1A TNFRSF1B
2 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B
Sources

Sources for Guillain-Barre Syndrome

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....