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MCID: GMC001
MIFTS: 32

Gum Cancer

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Related diseases Publications Pathways
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Aliases & Classifications for Gum Cancer

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MalaCards integrated aliases for Gum Cancer:

Name: Gum Cancer 12 15 17
Malignant Neoplasm of Gum 12 32
Malignant Tumor of Gum 12 71
Malignant Neoplasm of Other Sites of Gum 12
Malignant Tumour of Gingiva 12
Malignant Gingival Tumor 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8602
ICD9CM 34 143
NCIt 50 C9317
SNOMED-CT 67 93819009
ICD10 32 C03 C03.9
UMLS 71 C0153364
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Summaries for Gum Cancer

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MalaCards based summary : Gum Cancer, also known as malignant neoplasm of gum, is related to upper gum cancer and lower gum cancer. An important gene associated with Gum Cancer is PER3 (Period Circadian Regulator 3), and among its related pathways/superpathways are Human cytomegalovirus infection and Mitotic G1-G1/S phases. Related phenotypes are Reduced mammosphere formation and behavior/neurological

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Related Diseases for Gum Cancer

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Diseases related to Gum Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 upper gum cancer 11.1
2 lower gum cancer 11.1
3 bile duct cystadenoma 10.2 PER3 ARNTL
4 splenic diffuse red pulp small b-cell lymphoma 10.1 TP53 CCNA2
5 apocrine adenosis of breast 10.1 TP53 CCNA2
6 thyroid lymphoma 10.0 TP53 CCNB1 CCNA2
7 anal carcinoma in situ 10.0 TP53 MYC
8 frontal lobe neoplasm 9.9 TP53 MYC
9 b cell prolymphocytic leukemia 9.9 TP53 MYC
10 suppressor of tumorigenicity 3 9.8 TP53 MYC
11 facial paralysis 9.8
12 vulva squamous cell carcinoma 9.7 WEE1 TP53
13 retinal cancer 9.7 TP53 MYC CCNB1 CCNA2
14 monoclonal gammopathy of uncertain significance 9.7 TP53 MYC IL6
15 colonic benign neoplasm 9.7 TP53 MYC IL6
16 breast adenocarcinoma 9.7 TP53 MYC CTSK CCNA2
17 central nervous system lymphoma 9.7 TP53 MYC IL6
18 pancreatic adenocarcinoma 9.7 TP53 IL6 CCNB1 CCNA2
19 breast carcinoma in situ 9.7 TP53 MYC IL6
20 hypotrichosis 1 9.7 TP53 MYC IL6
21 intestinal benign neoplasm 9.6 TP53 MYC IL6
22 mature b-cell neoplasm 9.6 TP53 MYC IL6
23 major depressive disorder 9.6 PER3 IL6 CRY2 CRY1 ARNTL
24 gastrointestinal system benign neoplasm 9.6 TP53 MYC IL6
25 advanced sleep phase syndrome 9.6 PER3 PER2 CSNK1E CRY2 CRY1 ARNTL
26 delayed sleep phase disorder 9.6 PER3 PER2 CSNK1E CRY2 CRY1 ARNTL
27 colon adenocarcinoma 9.6 TP53 MYC CCNB1 CCNA2
28 non-alcoholic steatohepatitis 9.6 TP53 PNPLA3 IL6
29 advanced sleep phase syndrome, familial, 1 9.6 PER3 PER2 CRY2 CRY1 CCNA2 ARNTL
30 colorectal adenoma 9.6 TP53 MYC IL6
31 amelogenesis imperfecta, type ig 9.6 TP53 MYC IL6
32 ocular cancer 9.6 TP53 MYC CCNA2
33 bone sarcoma 9.6 TP53 MYC IL6
34 leukocyte disease 9.6 TP53 MYC IL6
35 wilson disease 9.6 TP53 PNPLA3 IL6
36 kabuki syndrome 1 9.6 TP53 MYC IL6
37 gingival fibromatosis 9.6 TIMP2 MYC IL6
38 testicular cancer 9.5 TP53 MYC IL6 CCNA2
39 bone marrow cancer 9.5 TP53 MYC IL6
40 adenomyosis 9.5 TP53 TIMP2 IL6
41 cervical squamous cell carcinoma 9.4 TP53 TIMP2 MYC
42 acquired immunodeficiency syndrome 9.4 TP53 MYC IL6
43 osteogenic sarcoma 9.4 TP53 MYC IL6 EZR
44 sleep disorder 9.3 PER3 PER2 IL6 CSNK1E CRY2 CRY1
45 bipolar disorder 9.3 PER3 PER2 IL6 CSNK1E CRY2 CRY1
46 squamous cell carcinoma, head and neck 9.2 TP53 TIMP2 MYC CCNB1 CCNA2
47 body mass index quantitative trait locus 11 9.2 TP53 PNPLA3 PER2 IL6 CTSK ARNTL
48 medulloblastoma 9.2 WEE1 TP53 MYC IL6 EZR CCNB1
49 endometrial cancer 8.9 TP53 TIMP2 MYC EZR CCNB1 CCNA2
50 disease of mental health 8.5 TP53 PER3 PER2 NTSR1 MYC IL6

Graphical network of the top 20 diseases related to Gum Cancer:



Diseases related to Gum Cancer
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Symptoms & Phenotypes for Gum Cancer

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GenomeRNAi Phenotypes related to Gum Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CSNK1E CTSK MYC NTSR1 PER3 TIMP2

MGI Mouse Phenotypes related to Gum Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ARNTL CCNB1 CRY1 CRY2 CSNK1E CTSK
2 growth/size/body region MP:0005378 10.15 ARNTL CRY1 CRY2 CTSK EZR IL6
3 adipose tissue MP:0005375 10.06 ARNTL CRY1 CRY2 IL6 MYC NTSR1
4 hematopoietic system MP:0005397 10.06 ARNTL CCNA2 CRY1 CRY2 CTSK IL6
5 immune system MP:0005387 9.96 ARNTL CCNA2 CRY1 CRY2 CTSK EZR
6 digestive/alimentary MP:0005381 9.95 CTSK EZR IL6 MYC NTSR1 PER2
7 integument MP:0010771 9.76 ARNTL CRY1 CRY2 IL6 MYC NTSR1
8 liver/biliary system MP:0005370 9.5 ARNTL CRY2 IL6 MYC PER2 PNPLA3
9 nervous system MP:0003631 9.44 ARNTL CRY1 CRY2 CSNK1E CTSK IL6
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Drugs & Therapeutics for Gum Cancer

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Search Clinical Trials , NIH Clinical Center for Gum Cancer

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Genetic Tests for Gum Cancer

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Anatomical Context for Gum Cancer

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Publications for Gum Cancer

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Articles related to Gum Cancer:

# Title Authors PMID Year
1
Holistic reconstruction of mandible defect, lower lip and chin sensation, and smile reanimation in an advanced gum cancer patient: A case report. 61
33185301 2020
2
Analysis of the Filipinos' Interest in Searching Online for Oral Cancer. 61
32334480 2020
3
Ulnar forearm osteocutaneous flap harvesting using Kapandji procedure for pre-existing complicated fibular flap on mandible reconstruction--cadaveric and clinical study. 61
25882534 2015
4
A prospective study of one-carbon metabolism biomarkers and cancer of the head and neck and esophagus. 61
24975698 2015
5
A pilot study of segmental mandibulectomy with surgical navigation using fluorine-18 fluorodeoxyglucose positron-emission tomography/computed tomography. 61
22674660 2012
6
Thalidomide-related vessel thrombosis in microsurgical free tissue transfer. 61
19904702 2010
7
Radiation-induced cancer after radiotherapy for non-Hodgkin's lymphoma of the head and neck: a retrospective study. 61
19591686 2009
8
Total lower lip reconstruction with a composite radial forearm-palmaris longus tendon flap: a clinical series. 61
14707618 2004
9
Trends and spatial distribution of oral cancer mortality in São Paulo, Brazil, 1980-1998. 61
11337266 2001
10
[Planning for brachytherapy using a 3D-simulation model]. 61
7638059 1995
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Variations for Gum Cancer

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Expression for Gum Cancer

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Search GEO for disease gene expression data for Gum Cancer.
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Pathways for Gum Cancer

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Pathways related to Gum Cancer according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Human cytomegalovirus infection 36
Show member pathways
 12.83 WEE1 TP53 MYC IL6 CCNB1
2
Mitotic G1-G1/S phases 65
Show member pathways
 12.44 WEE1 TP53 MYC CCNB1 CCNA2
3
DNA Damage 4
12.39 WEE1 TP53 CCNB1 CCNA2
4
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.38 TP53 CRY1 CCNB1 CCNA2
5
WNT Signaling 63
12.31 TP53 MYC CSNK1E CCNA2
6
Cyclins and Cell Cycle Regulation 63
Show member pathways
 12.25 WEE1 TP53 CCNB1 CCNA2
7
Human T-cell leukemia virus 1 infection 36
12.23 TP53 MYC IL6 CCNA2
8
Cell cycle 36 1
12.23 WEE1 TP53 MYC CCNB1 CCNA2
9
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.16 TP53 TIMP2 MYC IL6
10
Transcriptional misregulation in cancer 36
12.14 TP53 PER2 MYC IL6 CCNA2
11
BMAL1-CLOCK,NPAS2 activates circadian gene expression 65
Show member pathways
 12.08 PER2 CSNK1E CRY2 CRY1 ARNTL
13
Cellular senescence (KEGG) 36
11.96 TP53 MYC IL6 CCNB1 CCNA2
14
Spinal Cord Injury 1
11.91 TP53 MYC IL6
15
Interleukin-4 and 13 signaling 65
11.88 TP53 MYC IL6
16
TP53 Regulates Transcription of Cell Cycle Genes 65
Show member pathways
 11.82 TP53 CCNB1 CCNA2
17
Validated targets of C-MYC transcriptional activation 1
11.69 TP53 MYC CCNB1
18
Retinoblastoma (RB) in Cancer 1
11.6 WEE1 TP53 MYC CCNB1 CCNA2
19
p53 pathway 1
11.53 TP53 CSNK1E CCNA2
20
Photodynamic therapy-induced AP-1 survival signaling. 1
11.46 TP53 IL6 CCNA2
21
Hepatitis C and Hepatocellular Carcinoma 1
11.45 TP53 MYC IL6
22
Cell cycle Role of 14-3-3 proteins in cell cycle regulation 23
Show member pathways
 11.39 WEE1 TP53 CCNB1
23
DNA damage_ATM/ATR regulation of G1/S checkpoint 23
11.37 TP53 MYC CCNA2
24
LKB1 signaling events 1
11.34 TP53 MYC EZR
25
Diurnally Regulated Genes with Circadian Orthologs 1
11.31 PER2 CRY2 CRY1 ARNTL
26
Cyclin A/B1 associated events during G2/M transition 65
Show member pathways
 11.23 WEE1 CCNB1 CCNA2
27
GADD45 Pathway 63
11.18 TP53 CCNB1 CCNA2
28
Circadian rhythm 36
Show member pathways
 11.07 PER3 PER2 CSNK1E CRY2 CRY1 ARNTL
29
DNA Damage Induced 14-3-3Sigma Signaling 63
10.93 TP53 CCNB1
30
Circadian rhythm pathway 1
10.78 CSNK1E ARNTL
31
Melatonin metabolism and effects 1
10.67 PER3 PER2 CSNK1E CRY2 CRY1 ARNTL
32
Metabolic States and Circadian Oscillators 63
Show member pathways
 10.66 CRY2 CRY1 ARNTL
Sources

GO Terms for Gum Cancer

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Cellular components related to Gum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 WEE1 TP53 PNPLA3 PER3 PER2 NTSR1

Biological processes related to Gum Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.02 TP53 PER2 MYC IL6 CCNA2 ARNTL
2 negative regulation of transcription, DNA-templated GO:0045892 10 TP53 PER2 CRY2 CRY1 ARNTL
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.98 TP53 PER3 PER2 MYC EZR CRY2
4 response to drug GO:0042493 9.92 TP53 TIMP2 MYC CCNB1
5 regulation of cell cycle GO:0051726 9.83 TP53 PER2 CCNB1 ARNTL
6 G2/M transition of mitotic cell cycle GO:0000086 9.81 WEE1 CSNK1E CCNB1 CCNA2
7 glucose homeostasis GO:0042593 9.8 IL6 CRY2 CRY1
8 cellular response to hypoxia GO:0071456 9.8 TP53 MYC CCNB1 CCNA2
9 regulation of insulin secretion GO:0050796 9.75 PER2 IL6 ARNTL
10 response to activity GO:0014823 9.74 IL6 CRY2 CRY1
11 positive regulation of fibroblast proliferation GO:0048146 9.73 MYC CCNB1 CCNA2
12 regulation of circadian rhythm GO:0042752 9.71 PER2 CSNK1E CRY2 CRY1
13 circadian rhythm GO:0007623 9.65 TP53 PER2 CRY2 CRY1 ARNTL
14 protein-chromophore linkage GO:0018298 9.62 CRY2 CRY1
15 regulation of cellular senescence GO:2000772 9.61 TP53 ARNTL
16 white fat cell differentiation GO:0050872 9.61 PNPLA3 PER2
17 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.59 TP53 IL6
18 response to glucagon GO:0033762 9.58 CRY1 CCNA2
19 entrainment of circadian clock by photoperiod GO:0043153 9.55 TP53 PER3 PER2 CRY2 CRY1
20 oxidative stress-induced premature senescence GO:0090403 9.54 TP53 ARNTL
21 negative regulation of circadian rhythm GO:0042754 9.54 PER2 CRY2 CRY1
22 negative regulation of glucocorticoid receptor signaling pathway GO:2000323 9.5 CRY2 CRY1 ARNTL
23 rhythmic process GO:0048511 9.5 TP53 PER3 PER2 CSNK1E CRY2 CRY1
24 negative regulation of glucocorticoid secretion GO:2000850 9.48 CRY2 CRY1
25 blue light signaling pathway GO:0009785 9.46 CRY2 CRY1
26 circadian regulation of gene expression GO:0032922 9.1 PER3 PER2 CSNK1E CRY2 CRY1 ARNTL

Molecular functions related to Gum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 TP53 CRY2 CRY1 CCNB1 CCNA2
2 E-box binding GO:0070888 9.5 MYC CRY1 ARNTL
3 core promoter sequence-specific DNA binding GO:0001046 9.46 TP53 MYC
4 photoreceptor activity GO:0009881 9.43 CRY2 CRY1
5 transcription corepressor binding GO:0001222 9.4 PER3 PER2
6 blue light photoreceptor activity GO:0009882 9.26 CRY2 CRY1
7 DNA (6-4) photolyase activity GO:0003914 9.16 CRY2 CRY1
8 transcription regulatory region sequence-specific DNA binding GO:0000976 9.02 TP53 PER3 PER2 CRY2 ARNTL
9 deoxyribodipyrimidine photo-lyase activity GO:0003904 8.96 CRY2 CRY1
Sources

Sources for Gum Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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