Gummatous Syphilis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Gummatous Syphilis

MalaCards integrated aliases for Gummatous Syphilis:

Name: Gummatous Syphilis ¹¹ ¹⁴

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0050584

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Summaries for Gummatous Syphilis

Disease Ontology: ¹¹ A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ.

MalaCards based summary: Gummatous Syphilis is related to syphilis and tertiary syphilis. An important gene associated with Gummatous Syphilis is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways is Alanine and aspartate metabolism. Affiliated tissues include testes, liver and trachea.

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Related Diseases for Gummatous Syphilis

Diseases related to Gummatous Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)

#	Related Disease	Score	Top Affiliating Genes
1	syphilis	31.1	TPR GPT CRP CD4
2	tertiary syphilis	30.3	TPR TCHH CRP CD4
3	blastomycosis	30.2	CRP CD4
4	primary syphilis	30.2	TPR RPSA EPB41L3 CD4
5	peliosis hepatis	30.1	GPT AFP
6	cardiovascular syphilis	10.4	TPR TCHH
7	bejel	10.4	TPR EPB41L3
8	early yaws	10.3	TPR CD4
9	latent syphilis	10.3	TPR CD4
10	emphysematous cholecystitis	10.3	GPT CRP
11	klebsiella pneumonia	10.3	GPT CRP
12	spontaneous tension pneumothorax	10.3	GPT CRP
13	tabes dorsalis	10.3	TCHH CD4
14	viral laryngitis	10.3	GPT CRP
15	yaws	10.3	TPR RNF112 EPB41L3
16	hemopneumothorax	10.3	GPT CRP
17	intestinal tuberculosis	10.3	CRP CD4
18	ascending cholangitis	10.3	GPT CRP
19	late congenital syphilis	10.3	GPT CRP
20	hydrops of gallbladder	10.3	GPT CRP
21	lateral medullary syndrome	10.3	PNMA2 CRP
22	suppurative cholangitis	10.3	GPT CRP
23	mesenteric lymphadenitis	10.2	GPT CRP
24	ankylosing spondylitis 1	10.2	GPT CRP
25	ventilation pneumonitis	10.2	CRP CD4
26	syphilitic meningitis	10.2	CRP CD4
27	panophthalmitis	10.2	CRP CD4
28	paralytic ileus	10.2	GPT CRP
29	multiple cranial nerve palsy	10.2	CRP CD4
30	intracranial abscess	10.2	CRP CD4
31	purulent endophthalmitis	10.2	CRP CD4
32	suppurative lymphadenitis	10.2	CRP CD4
33	cavernous sinus thrombosis	10.2	CRP CD4
34	urogenital tuberculosis	10.2	CRP CD4
35	pyomyositis	10.2	CRP CD4
36	granulomatous angiitis	10.2	CRP CD4
37	acute necrotizing pancreatitis	10.2	GPT CRP
38	epidural abscess	10.2	CRP CD4
39	breast abscess	10.2	CRP CD4
40	endemic typhus	10.2	GPT CRP
41	neuroretinitis	10.2	CRP CD4
42	optic papillitis	10.2	CRP CD4
43	recurrent hypersomnia	10.2	PNMA2 LGI1
44	necrotizing gastritis	10.2	GPT CRP
45	lymph node tuberculosis	10.2	CRP CD4
46	granulomatous dermatitis	10.2	CRP CD4
47	nocardiosis	10.2	CRP CD4
48	kleine-levin hibernation syndrome	10.2	PNMA2 LGI1
49	arachnoiditis	10.2	CRP CD4
50	orbital cellulitis	10.2	CRP CD4

Graphical network of the top 20 diseases related to Gummatous Syphilis:

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Symptoms & Phenotypes for Gummatous Syphilis

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Drugs & Therapeutics for Gummatous Syphilis

Search Clinical Trials, NIH Clinical Center for Gummatous Syphilis

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Genetic Tests for Gummatous Syphilis

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Anatomical Context for Gummatous Syphilis

Organs/tissues related to Gummatous Syphilis:

MalaCards : Testes, Liver, Trachea, Adrenal Gland, Skin, Bone

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Publications for Gummatous Syphilis

Articles related to Gummatous Syphilis:

(show all 32)

#	Title	Authors	PMID	Year
1	Gummatous Syphilis: A Rare Entity Mimicking Carcinoma Penis. ⁶²	Mathew J...Vaiphei K	32882307	2020
2	Gummatous syphilis: A case report. ⁶²	Alikhani A...Montazer F	31437386	2019
3	Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. ⁶²	Landry T...Singh AE	31230001	2019
4	Gummatous Syphilis Mimicking Malignant Bone Tumor on FDG PET/CT. ⁶²	Wang LJ...Wang QS	30672757	2019
5	A rare case of a chronic syphilitic gumma in a man infected with human immunodeficiency virus. ⁶²	Masege SD...Karstaedt A	24909596	2014
6	Gummatous syphilis of the adrenal gland. ⁶²	Scheurkogel MM...Quarles van Ufford HM	22889800	2012
7	When infections collide--gummatous syphilis in an HIV-infected individual. ⁶²	McVey M...MacPherson P	20338797	2010
8	[The value of disregarding the number of years. Blood and cerebrospinal fluid syphilis serology: gummatous syphilis]. ⁶²	Ricard D...De Greslan T	19623707	2009
9	Peliosis and gummatous syphilis of the liver: a case report. ⁶²	Chen JF...Zhang WY	18350643	2008
10	[Gummatous syphilis of the liver]. ⁶²	Ponomarev AA	8815268	1995
11	[Tertiary gummatous syphilis of the liver--an unexpected disease today. Report of two cases]. ⁶²	Dammrich J...Altmann HW	1533893	1992
12	Benign tertiary syphilis and HIV infection. ⁶²	Dawson S...Lawrence AG	3140837	1988
13	Gummatous syphilis: a reminder. ⁶²	Rodriguez S...Apstein MD	3343534	1988
14	An unusual presentation of oral syphilis. ⁶²	Jefferies SD...Ord RA	2932152	1985
15	[Wegener's granulomatosis simulating gummatous syphilis]. ⁶²	Nosatenko VE...Shakhova FB	4090416	1985
16	[Rare case of a malignant course in tertiary gummatous syphilis]. ⁶²	Kovalev VM...Pino OS	4002855	1985
17	[Benign late syphilis: 2 cases, gummatous syphilis and nodular syphilis]. ⁶²	Lloret Cano A...Vilata Corell JJ	6384699	1984
18	[Case of gummatous syphilis in a 10-year-old boy]. ⁶²	Gribovod AF...Anistratenko GI	532335	1979
19	Gummatous Syphilis. ⁶²	Acharya KM...Danidharia VM	28223620	1979
20	[Clinico-radiologic manifestations of gummatous syphilis involving the soft tissues]. ⁶²	Khazov PD	5563605	1971
21	[Partial hepatectomy for unrecognized congenital sclero-gummatous syphilis]. ⁶²	DEBRE R...BREVART P	13884701	1962
22	[Sudden death in gummatous syphilis of the larynx & trachea]. ⁶²	PORKSHEIAN OKh	13557591	1958
23	[Tuberculosis cutis luposa (papulo-ulcerous) and tubero-serpiginous & gummatous syphilis; casuistic contribution on the clinical features of both syndromes]. ⁶²	KRUGER H...LUCIUS K	13486823	1957
24	[Value of potassium iodide trial therapy in grave gummatous syphilis and simple iodine-bismuth therapy during late latency]. ⁶²	HOFFMANN E	13444129	1957
25	[Diagnosis of gummatous syphilis of lungs with reference to one case]. ⁶²	DZHUROV G	13455432	1956
26	[Pathology of syphilis of trachea; with contribution to penicillin therapy of gummatous syphilis]. ⁶²	HERZOG W...CONRAD FW	14375086	1955
27	[Gummatous syphilis of the face]. ⁶²	BERGMANN	14901963	1951
28	[Deep blastomycosis of the skin and gummatous syphilis]. ⁶²	IBRAGIMOV FI	14817945	1951
29	[A case of pulmonary gummatous syphilis]. ⁶²	SANCHEZ-BARRIGA CARAPETO M	15409594	1949
30	Benign late gummatous syphilis occurring more than 40 years after infection. ⁶²	WIGGALL RH...HAHN RD	18121298	1949
31	Late gummatous syphilis resistant to treatment with penicillin: case report. ⁶²	HAHN RD	20262386	1947
32	Penicillin treatment of benign late gummatous syphilis; a report of twenty-one cases. ⁶²	DEXTER DD...TUCKER HA	20984455	1946

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Genes for Gummatous Syphilis

Genes related to Gummatous Syphilis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TPR	Translocated Promoter Region, Nuclear Basket Protein	Protein Coding	5.47	DISEASES inferred ¹⁴
2	EPB41L3	Erythrocyte Membrane Protein Band 4.1 Like 3	Protein Coding	4.35	DISEASES inferred ¹⁴
3	TCHH	Trichohyalin	Protein Coding	4.31	DISEASES inferred ¹⁴
4	RNF112	Ring Finger Protein 112	Protein Coding	4.23	DISEASES inferred ¹⁴
5	RPSA	Ribosomal Protein SA	Protein Coding	4.05	DISEASES inferred ¹⁴
6	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	3.98	DISEASES inferred ¹⁴
7	AMPH	Amphiphysin	Protein Coding	3.75	DISEASES inferred ¹⁴
8	PNMA2	PNMA Family Member 2	Protein Coding	3.74	DISEASES inferred ¹⁴
9	CRP	C-Reactive Protein	Protein Coding	3.72	DISEASES inferred ¹⁴
10	CD4	CD4 Molecule	Protein Coding	3.66	DISEASES inferred ¹⁴
11	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	3.64	DISEASES inferred ¹⁴
12	CNTNAP2	Contactin Associated Protein 2	Protein Coding	3.52	DISEASES inferred ¹⁴
13	GAD2	Glutamate Decarboxylase 2	Protein Coding	3.23	DISEASES inferred ¹⁴
14	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	3.2	DISEASES inferred ¹⁴
15	AFP	Alpha Fetoprotein	Protein Coding	3.04	DISEASES inferred ¹⁴
16	ELN	Elastin	Protein Coding	2.78	DISEASES inferred ¹⁴

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Variations for Gummatous Syphilis

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Expression for Gummatous Syphilis

Search GEO for disease gene expression data for Gummatous Syphilis.

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Pathways for Gummatous Syphilis

Pathways related to Gummatous Syphilis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Alanine and aspartate metabolism ⁷⁴	9.7	GPT GAD2

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GO Terms for Gummatous Syphilis

Cellular components related to Gummatous Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	juxtaparanode region of axon	GO:0044224	8.92	EPB41L3 CNTNAP2

Biological processes related to Gummatous Syphilis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein localization to juxtaparanode region of axon	GO:0071205	8.92	EPB41L3 CNTNAP2

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Sources for Gummatous Syphilis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: GMM001 MIFTS: 21	Gummatous Syphilis Categories: Infectious diseases	Data Licensing For inquiries, contact: [email protected]
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