MCID: GMM001
MIFTS: 21

Gummatous Syphilis

Categories: Infectious diseases
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Aliases & Classifications for Gummatous Syphilis

MalaCards integrated aliases for Gummatous Syphilis:

Name: Gummatous Syphilis 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0050584

Summaries for Gummatous Syphilis

Disease Ontology: 11 A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ.

MalaCards based summary: Gummatous Syphilis is related to syphilis and tertiary syphilis. An important gene associated with Gummatous Syphilis is TPR (Translocated Promoter Region, Nuclear Basket Protein), and among its related pathways/superpathways is Alanine and aspartate metabolism. Affiliated tissues include testes, liver and trachea.

Related Diseases for Gummatous Syphilis

Diseases related to Gummatous Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 syphilis 31.1 TPR GPT CRP CD4
2 tertiary syphilis 30.3 TPR TCHH CRP CD4
3 blastomycosis 30.2 CRP CD4
4 primary syphilis 30.2 TPR RPSA EPB41L3 CD4
5 peliosis hepatis 30.1 GPT AFP
6 cardiovascular syphilis 10.4 TPR TCHH
7 bejel 10.4 TPR EPB41L3
8 early yaws 10.3 TPR CD4
9 latent syphilis 10.3 TPR CD4
10 emphysematous cholecystitis 10.3 GPT CRP
11 klebsiella pneumonia 10.3 GPT CRP
12 spontaneous tension pneumothorax 10.3 GPT CRP
13 tabes dorsalis 10.3 TCHH CD4
14 viral laryngitis 10.3 GPT CRP
15 yaws 10.3 TPR RNF112 EPB41L3
16 hemopneumothorax 10.3 GPT CRP
17 intestinal tuberculosis 10.3 CRP CD4
18 ascending cholangitis 10.3 GPT CRP
19 late congenital syphilis 10.3 GPT CRP
20 hydrops of gallbladder 10.3 GPT CRP
21 lateral medullary syndrome 10.3 PNMA2 CRP
22 suppurative cholangitis 10.3 GPT CRP
23 mesenteric lymphadenitis 10.2 GPT CRP
24 ankylosing spondylitis 1 10.2 GPT CRP
25 ventilation pneumonitis 10.2 CRP CD4
26 syphilitic meningitis 10.2 CRP CD4
27 panophthalmitis 10.2 CRP CD4
28 paralytic ileus 10.2 GPT CRP
29 multiple cranial nerve palsy 10.2 CRP CD4
30 intracranial abscess 10.2 CRP CD4
31 purulent endophthalmitis 10.2 CRP CD4
32 suppurative lymphadenitis 10.2 CRP CD4
33 cavernous sinus thrombosis 10.2 CRP CD4
34 urogenital tuberculosis 10.2 CRP CD4
35 pyomyositis 10.2 CRP CD4
36 granulomatous angiitis 10.2 CRP CD4
37 acute necrotizing pancreatitis 10.2 GPT CRP
38 epidural abscess 10.2 CRP CD4
39 breast abscess 10.2 CRP CD4
40 endemic typhus 10.2 GPT CRP
41 neuroretinitis 10.2 CRP CD4
42 optic papillitis 10.2 CRP CD4
43 recurrent hypersomnia 10.2 PNMA2 LGI1
44 necrotizing gastritis 10.2 GPT CRP
45 lymph node tuberculosis 10.2 CRP CD4
46 granulomatous dermatitis 10.2 CRP CD4
47 nocardiosis 10.2 CRP CD4
48 kleine-levin hibernation syndrome 10.2 PNMA2 LGI1
49 arachnoiditis 10.2 CRP CD4
50 orbital cellulitis 10.2 CRP CD4

Graphical network of the top 20 diseases related to Gummatous Syphilis:



Diseases related to Gummatous Syphilis

Symptoms & Phenotypes for Gummatous Syphilis

Drugs & Therapeutics for Gummatous Syphilis

Search Clinical Trials, NIH Clinical Center for Gummatous Syphilis

Genetic Tests for Gummatous Syphilis

Anatomical Context for Gummatous Syphilis

Organs/tissues related to Gummatous Syphilis:

MalaCards : Testes, Liver, Trachea, Adrenal Gland, Skin, Bone

Publications for Gummatous Syphilis

Articles related to Gummatous Syphilis:

(show all 32)
# Title Authors PMID Year
1
Gummatous Syphilis: A Rare Entity Mimicking Carcinoma Penis. 62
32882307 2020
2
Gummatous syphilis: A case report. 62
31437386 2019
3
Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. 62
31230001 2019
4
Gummatous Syphilis Mimicking Malignant Bone Tumor on FDG PET/CT. 62
30672757 2019
5
A rare case of a chronic syphilitic gumma in a man infected with human immunodeficiency virus. 62
24909596 2014
6
Gummatous syphilis of the adrenal gland. 62
22889800 2012
7
When infections collide--gummatous syphilis in an HIV-infected individual. 62
20338797 2010
8
[The value of disregarding the number of years. Blood and cerebrospinal fluid syphilis serology: gummatous syphilis]. 62
19623707 2009
9
Peliosis and gummatous syphilis of the liver: a case report. 62
18350643 2008
10
[Gummatous syphilis of the liver]. 62
8815268 1995
11
[Tertiary gummatous syphilis of the liver--an unexpected disease today. Report of two cases]. 62
1533893 1992
12
Benign tertiary syphilis and HIV infection. 62
3140837 1988
13
Gummatous syphilis: a reminder. 62
3343534 1988
14
An unusual presentation of oral syphilis. 62
2932152 1985
15
[Wegener's granulomatosis simulating gummatous syphilis]. 62
4090416 1985
16
[Rare case of a malignant course in tertiary gummatous syphilis]. 62
4002855 1985
17
[Benign late syphilis: 2 cases, gummatous syphilis and nodular syphilis]. 62
6384699 1984
18
[Case of gummatous syphilis in a 10-year-old boy]. 62
532335 1979
19
Gummatous Syphilis. 62
28223620 1979
20
[Clinico-radiologic manifestations of gummatous syphilis involving the soft tissues]. 62
5563605 1971
21
[Partial hepatectomy for unrecognized congenital sclero-gummatous syphilis]. 62
13884701 1962
22
[Sudden death in gummatous syphilis of the larynx & trachea]. 62
13557591 1958
23
[Tuberculosis cutis luposa (papulo-ulcerous) and tubero-serpiginous & gummatous syphilis; casuistic contribution on the clinical features of both syndromes]. 62
13486823 1957
24
[Value of potassium iodide trial therapy in grave gummatous syphilis and simple iodine-bismuth therapy during late latency]. 62
13444129 1957
25
[Diagnosis of gummatous syphilis of lungs with reference to one case]. 62
13455432 1956
26
[Pathology of syphilis of trachea; with contribution to penicillin therapy of gummatous syphilis]. 62
14375086 1955
27
[Gummatous syphilis of the face]. 62
14901963 1951
28
[Deep blastomycosis of the skin and gummatous syphilis]. 62
14817945 1951
29
[A case of pulmonary gummatous syphilis]. 62
15409594 1949
30
Benign late gummatous syphilis occurring more than 40 years after infection. 62
18121298 1949
31
Late gummatous syphilis resistant to treatment with penicillin: case report. 62
20262386 1947
32
Penicillin treatment of benign late gummatous syphilis; a report of twenty-one cases. 62
20984455 1946

Variations for Gummatous Syphilis

Expression for Gummatous Syphilis

Search GEO for disease gene expression data for Gummatous Syphilis.

Pathways for Gummatous Syphilis

Pathways related to Gummatous Syphilis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 GPT GAD2

GO Terms for Gummatous Syphilis

Cellular components related to Gummatous Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 juxtaparanode region of axon GO:0044224 8.92 EPB41L3 CNTNAP2

Biological processes related to Gummatous Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein localization to juxtaparanode region of axon GO:0071205 8.92 EPB41L3 CNTNAP2

Sources for Gummatous Syphilis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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