MCID: GMM001
MIFTS: 17

Gummatous Syphilis

Categories: Infectious diseases

Aliases & Classifications for Gummatous Syphilis

MalaCards integrated aliases for Gummatous Syphilis:

Name: Gummatous Syphilis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050584

Summaries for Gummatous Syphilis

Disease Ontology : 12 A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ.

MalaCards based summary : Gummatous Syphilis is related to syphilis and blastomycosis. An important gene associated with Gummatous Syphilis is RNF112 (Ring Finger Protein 112). Affiliated tissues include bone, liver and testes, and related phenotype is Decreased Aire reporter expression.

Related Diseases for Gummatous Syphilis

Diseases related to Gummatous Syphilis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 syphilis 10.8
2 blastomycosis 10.1
3 bone inflammation disease 10.1
4 primary syphilis 10.1
5 tertiary syphilis 10.1
6 peliosis hepatis 10.1
7 47,xyy 10.1
8 cardiovascular syphilis 9.5 TCHH KAT8
9 bejel 9.5 RNF112 EPB41L3

Graphical network of the top 20 diseases related to Gummatous Syphilis:



Diseases related to Gummatous Syphilis

Symptoms & Phenotypes for Gummatous Syphilis

GenomeRNAi Phenotypes related to Gummatous Syphilis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Aire reporter expression GR00304-A 8.62 HOPX KAT8

Drugs & Therapeutics for Gummatous Syphilis

Search Clinical Trials , NIH Clinical Center for Gummatous Syphilis

Genetic Tests for Gummatous Syphilis

Anatomical Context for Gummatous Syphilis

MalaCards organs/tissues related to Gummatous Syphilis:

40
Bone, Liver, Testes, Trachea, Lung, Adrenal Gland, Skin

Publications for Gummatous Syphilis

Articles related to Gummatous Syphilis:

(show all 31)
# Title Authors PMID Year
1
Gummatous syphilis: A case report. 61
31437386 2019
2
Retrospective review of tertiary and neurosyphilis cases in Alberta, 1973-2017. 61
31230001 2019
3
Gummatous Syphilis Mimicking Malignant Bone Tumor on FDG PET/CT. 61
30672757 2019
4
A rare case of a chronic syphilitic gumma in a man infected with human immunodeficiency virus. 61
24909596 2014
5
Gummatous syphilis of the adrenal gland. 61
22889800 2012
6
When infections collide--gummatous syphilis in an HIV-infected individual. 61
20338797 2010
7
[The value of disregarding the number of years. Blood and cerebrospinal fluid syphilis serology: gummatous syphilis]. 61
19623707 2009
8
Peliosis and gummatous syphilis of the liver: a case report. 61
18350643 2008
9
[Gummatous syphilis of the liver]. 61
8815268 1995
10
[Tertiary gummatous syphilis of the liver--an unexpected disease today. Report of two cases]. 61
1533893 1992
11
Benign tertiary syphilis and HIV infection. 61
3140837 1988
12
Gummatous syphilis: a reminder. 61
3343534 1988
13
[Wegener's granulomatosis simulating gummatous syphilis]. 61
4090416 1985
14
An unusual presentation of oral syphilis. 61
2932152 1985
15
[Rare case of a malignant course in tertiary gummatous syphilis]. 61
4002855 1985
16
[Benign late syphilis: 2 cases, gummatous syphilis and nodular syphilis]. 61
6384699 1984
17
Gummatous Syphilis. 61
28223620 1979
18
[Case of gummatous syphilis in a 10-year-old boy]. 61
532335 1979
19
[Clinico-radiologic manifestations of gummatous syphilis involving the soft tissues]. 61
5563605 1971
20
[Partial hepatectomy for unrecognized congenital sclero-gummatous syphilis]. 61
13884701 1962
21
[Sudden death in gummatous syphilis of the larynx & trachea]. 61
13557591 1958
22
[Tuberculosis cutis luposa (papulo-ulcerous) and tubero-serpiginous & gummatous syphilis; casuistic contribution on the clinical features of both syndromes]. 61
13486823 1957
23
[Value of potassium iodide trial therapy in grave gummatous syphilis and simple iodine-bismuth therapy during late latency]. 61
13444129 1957
24
[Diagnosis of gummatous syphilis of lungs with reference to one case]. 61
13455432 1956
25
[Pathology of syphilis of trachea; with contribution to penicillin therapy of gummatous syphilis]. 61
14375086 1955
26
[Gummatous syphilis of the face]. 61
14901963 1951
27
[Deep blastomycosis of the skin and gummatous syphilis]. 61
14817945 1951
28
[A case of pulmonary gummatous syphilis]. 61
15409594 1949
29
Benign late gummatous syphilis occurring more than 40 years after infection. 61
18121298 1949
30
Late gummatous syphilis resistant to treatment with penicillin: case report. 61
20262386 1947
31
Penicillin treatment of benign late gummatous syphilis; a report of twenty-one cases. 61
20984455 1946

Variations for Gummatous Syphilis

Expression for Gummatous Syphilis

Search GEO for disease gene expression data for Gummatous Syphilis.

Pathways for Gummatous Syphilis

GO Terms for Gummatous Syphilis

Cellular components related to Gummatous Syphilis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density GO:0014069 8.62 RNF112 EPB41L3

Sources for Gummatous Syphilis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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