MCID: GTT002
MIFTS: 36

Guttate Psoriasis

Categories: Rare diseases, Skin diseases, Gastrointestinal diseases

Aliases & Classifications for Guttate Psoriasis

MalaCards integrated aliases for Guttate Psoriasis:

Name: Guttate Psoriasis 53 73
Psoriasis Guttate 53

Classifications:



External Ids:

ICD10 33 L40.4
UMLS 73 C0343052

Summaries for Guttate Psoriasis

NIH Rare Diseases : 53 Guttate psoriasis is a skin condition in which small, red, and scaly teardrop-shaped spots appear on the arms, legs, and middle of the body. It is a relatively uncommon form of psoriasis. The condition often develops very suddenly, and is usually triggered by an infection (e.g., strep throat, bacteria infection, upper respiratory infections or other viral infections). Other triggers include injury to the skin, including cuts, burns, and insect bites, certain malarial and heart medications, stress, sunburn, and excessive alcohol consumption. Treatment depends on the severity of the symptoms, ranging from at-home over the counter remedies to medicines that suppress the body's immune system to sunlight and phototherapy. 

MalaCards based summary : Guttate Psoriasis, also known as psoriasis guttate, is related to psoriasis and psoriasis 2. An important gene associated with Guttate Psoriasis is HLA-C (Major Histocompatibility Complex, Class I, C), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Benzocaine and Tofacitinib have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Guttate psoriasis (also known as eruptive psoriasis) is a type of psoriasis that presents as small... more...

Related Diseases for Guttate Psoriasis

Diseases related to Guttate Psoriasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 psoriasis 29.6 CAMP CDSN HLA-C ITGAL
2 psoriasis 2 10.3
3 psoriasis 7 10.3
4 psoriasis 11 10.3
5 psoriasis 13 10.3
6 dermatitis 10.1
7 kawasaki disease 10.0
8 crohn's disease 10.0
9 leukemia 9.9
10 tonsillitis 9.9
11 sarcoma 9.9
12 balanoposthitis 9.9
13 vulvovaginitis 9.9
14 influenza 9.9
15 scarlet fever 9.9
16 chickenpox 9.9
17 rosacea 9.9
18 pityriasis rosea 9.9
19 pityriasis lichenoides 9.9
20 pityriasis lichenoides chronica 9.9
21 pustular psoriasis 9.9
22 streptococcal group a invasive disease 9.9
23 birdshot chorioretinopathy 9.8 HLA-C KIR2DS1
24 diffuse infiltrative lymphocytosis syndrome 9.8 CDSN ITGAL
25 spondylitis 9.5 HLA-C NOD2
26 skin disease 9.5 CAMP CDSN HLA-C
27 psoriatic arthritis 9.4 HLA-C NOD2
28 behcet syndrome 9.1 HLA-C NOD2

Graphical network of the top 20 diseases related to Guttate Psoriasis:



Diseases related to Guttate Psoriasis

Symptoms & Phenotypes for Guttate Psoriasis

GenomeRNAi Phenotypes related to Guttate Psoriasis according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.29 HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.29 ITGAL
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.29 HLA-C
4 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.29 KIR2DS1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.29 HLA-C KIR2DS1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.29 ITGAL
7 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.29 KIR2DS1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.29 ITGAL KIR2DS1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.29 HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-132 10.29 ITGAL
11 Increased shRNA abundance (Z-score > 2) GR00366-A-140 10.29 KIR2DS1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.29 ITGAL
13 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.29 HLA-C ITGAL
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.29 HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.29 HLA-C ITGAL
16 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.29 KIR2DS1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-172 10.29 KIR2DS1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.29 HLA-C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.29 HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.29 KIR2DS1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-196 10.29 KIR2DS1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-198 10.29 KIR2DS1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.29 KIR2DS1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-2 10.29 ITGAL
25 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.29 HLA-C KIR2DS1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.29 KIR2DS1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-25 10.29 ITGAL
28 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.29 HLA-C
29 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.29 KIR2DS1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-4 10.29 ITGAL
31 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.29 HLA-C
32 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.29 ITGAL
33 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.29 HLA-C
34 Increased shRNA abundance (Z-score > 2) GR00366-A-73 10.29 KIR2DS1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.29 HLA-C
36 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.29 ITGAL
37 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.29 KIR2DS1
38 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.29 ITGAL
39 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.29 HLA-C KIR2DS1

Drugs & Therapeutics for Guttate Psoriasis

Drugs for Guttate Psoriasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
2
Tofacitinib Approved, Investigational Phase 3 477600-75-2
3
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
4 tannic acid Approved, Nutraceutical Phase 3
5 Analgesics Phase 3
6 Analgesics, Non-Narcotic Phase 3
7 Angiogenesis Inhibitors Phase 3
8 Angiogenesis Modulating Agents Phase 3
9 Peripheral Nervous System Agents Phase 3
10 Anti-Bacterial Agents Phase 3
11 Immunosuppressive Agents Phase 3
12 Anti-Infective Agents Phase 3
13 Protein Kinase Inhibitors Phase 3
14 Anti-Inflammatory Agents Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 3
16 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study To Evaluate The Effects And Safety Of Treatment, Treatment Withdrawal, Followed By Re-Treatment With CP-690,550 In Subjects With Moderate To Severe Chronic Plaque Psoriasis Completed NCT01186744 Phase 3 CP-690,550;CP-690,550;CP-690,550;CP-690,550
2 Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis. Completed NCT01232283 Phase 3 Apremilast;Placebo
3 Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis Completed NCT01194219 Phase 3 Apremilast;Placebo;Topical treatments or phototherapy
4 The Effect of Algae Dunaliella Bardawil on Psoriasis (2) Withdrawn NCT01121081 Phase 3 Alga Dunaliella Bardawil;Placebo
5 Determination of the Efficacy and Safety of Psirelax in the Relief of the Disease in Psoriasis Completed NCT01000714 Phase 2 Psirelax
6 Characterization of Cutaneous Microbiota in the Psoriasis Pathogenesis Completed NCT03475914

Search NIH Clinical Center for Guttate Psoriasis

Genetic Tests for Guttate Psoriasis

Anatomical Context for Guttate Psoriasis

MalaCards organs/tissues related to Guttate Psoriasis:

41
Skin, Heart, T Cells, Neutrophil, Tonsil

Publications for Guttate Psoriasis

Articles related to Guttate Psoriasis:

(show top 50) (show all 94)
# Title Authors Year
1
Anti-Programmed Cell Death-1-Induced Plaque and Guttate Psoriasis. ( 29527039 )
2018
2
Complete resolution of guttate psoriasis after tonsillectomy. ( 29554398 )
2018
3
Guttate psoriasis triggered by perianal streptococcal infection. ( 28543851 )
2017
4
Ustekinumab-induced remission of recalcitrant guttate psoriasis: A case series. ( 28932788 )
2017
5
Treatment of selective antibody deficiency with IVIG resulting in decreased frequency of streptococcal infection and improvement of guttate psoriasis. ( 29469743 )
2017
6
Phototherapy with Narrow-Band UVB in Adult Guttate Psoriasis: Results and Patient Assessment. ( 27883996 )
2016
7
Guttate psoriasis outcomes. ( 26919501 )
2016
8
Streptococcus pyogenes-induced cutaneous lymphocyte antigen-positive TA cell-dependent epidermal cell activation triggers TH17 responses in patients with guttate psoriasis. ( 27056267 )
2016
9
Frequency of streptococcal upper respiratory tract infections and HLA-Cw*06 allele in 70 patients with guttate psoriasis from northern Poland. ( 26755910 )
2015
10
Differentiation of pityriasis lichenoides chronica from guttate psoriasis by dermoscopy. ( 25682853 )
2015
11
Tissue and Serum Inflammatory Cytokine Levels in Korean Psoriasis Patients: A Comparison between Plaque and Guttate Psoriasis. ( 26719644 )
2015
12
Guttate Psoriasis Following Streptococcal Vulvovaginitis in a Five-year-old Girl. ( 26024939 )
2015
13
Recognizing Guttate Psoriasis and Initiating Appropriate Treatment. ( 26242029 )
2015
14
First presentation of guttate psoriasis triggered by acute tonsillitis. ( 25309672 )
2014
15
Localized guttate psoriasis in a patient with erythema migrans. ( 25350480 )
2014
16
Guttate psoriasis is associated with an intermediate phenotype of impaired Langerhans cell migration. ( 24628096 )
2014
17
Serum levels of LL-37 and inflammatory cytokines in plaque and guttate psoriasis. ( 25197165 )
2014
18
Effects of Malassezia yeasts on serum Th1 and Th2 cytokines in patients with guttate psoriasis. ( 22512309 )
2013
19
New Onset Guttate Psoriasis Following Pandemic H1N1 Influenza Vaccination. ( 24371399 )
2013
20
Expression patterns of Th1/Th2 transcription factors in patients with guttate psoriasis. ( 23827748 )
2013
21
Acute guttate psoriasis in a 15-year-old girl with Epstein-Barr virus infection. ( 22782168 )
2012
22
Rapid-onset skin rash. Guttate psoriasis. ( 22963026 )
2012
23
Complete resolution of guttate psoriasis following autologous SCT for Ewing's sarcoma in a pediatric patient. ( 22522571 )
2012
24
Dermacase. Can you identify this condition? Guttate psoriasis. ( 21252134 )
2011
25
The cholinergic system in guttate psoriasis with special reference to mast cells. ( 21521372 )
2011
26
Letter: A case of generalized guttate psoriasis induced by etanercept with relapse after abatacept. ( 21696691 )
2011
27
Foxp3+ regulatory T cells and related cytokines differentially expressed in plaque vs. guttate psoriasis vulgaris. ( 20222932 )
2010
28
Guttate psoriasis occurring on varicella lesions. ( 20883381 )
2010
29
To treat or not to treat? Management of guttate psoriasis and pityriasis rosea in patients with evidence of group A Streptococcal infection. ( 20232586 )
2010
30
Clinical course of guttate psoriasis: long-term follow-up study. ( 20860740 )
2010
31
Images in emergency medicine. Guttate psoriasis. ( 19303510 )
2009
32
Comparison of the Expression Profile of JunB, c-Jun, and S100A8 (Calgranulin A) in Psoriasis Vulgaris and Guttate Psoriasis. ( 20548852 )
2009
33
Guttate psoriasis triggered by chickenpox. ( 19755956 )
2009
34
An investigation of antistreptococcal antibody responses in guttate psoriasis. ( 18648827 )
2008
35
Efalizumab-induced guttate psoriasis. Successful management and re-treatment. ( 18569275 )
2008
36
Guttate psoriasis induced by infliximab in a child with Crohn's disease. ( 18383177 )
2008
37
Antistreptococcal treatment of guttate psoriasis: a controlled study. ( 18937661 )
2008
38
Expression of p53 in lesions and unaffected skin of patients with plaque-type and guttate psoriasis: a quantitative comparative study. ( 17535401 )
2007
39
Acute guttate psoriasis associated with streptococcal perianal dermatitis. ( 17164513 )
2007
40
Comparison of expression of heat-shock protein 60, Toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis. ( 18001412 )
2007
41
Winnie the Pooh and psoriasis too: an isomorphic response of guttate psoriasis in a tattoo. ( 17958785 )
2007
42
A 23-year-old Hispanic migrant fieldworker who presents with a painful rash on his limbs, trunk, and face. Guttate psoriasis. ( 17252683 )
2007
43
Guttate psoriasis. ( 16948384 )
2006
44
Suit PUVA as an effective and safe modality of treatment in guttate psoriasis. ( 16987282 )
2006
45
Acute guttate psoriasis patients have positive streptococcus hemolyticus throat cultures and elevated antistreptococcal M6 protein titers. ( 15906537 )
2005
46
Distinct HLA-C/KIR genotype profile associates with guttate psoriasis. ( 16185272 )
2005
47
Treatment of guttate psoriasis with a new two-compound product containing calcipotriol and betamethasone dipropionate. ( 16402632 )
2005
48
Guttate psoriasis-like lesions following BCG vaccination. ( 15233196 )
2004
49
Guttate psoriasis following Ecstasy ingestion. ( 15250894 )
2004
50
Role of Pityrosporum ovale in guttate psoriasis. ( 12692367 )
2003

Variations for Guttate Psoriasis

Expression for Guttate Psoriasis

Search GEO for disease gene expression data for Guttate Psoriasis.

Pathways for Guttate Psoriasis

GO Terms for Guttate Psoriasis

Cellular components related to Guttate Psoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 HLA-C ITGAL NOD2

Biological processes related to Guttate Psoriasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.43 CAMP KIR2DS1 NOD2
2 defense response GO:0006952 9.37 CAMP NOD2
3 neutrophil degranulation GO:0043312 9.33 CAMP HLA-C ITGAL
4 cell-cell adhesion GO:0098609 9.32 CDSN ITGAL
5 regulation of immune response GO:0050776 9.13 HLA-C ITGAL KIR2DS1
6 cellular response to peptidoglycan GO:0071224 8.62 CAMP NOD2

Sources for Guttate Psoriasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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