MCID: GYN003
MIFTS: 24

Gynandroblastoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Gynandroblastoma

MalaCards integrated aliases for Gynandroblastoma:

Name: Gynandroblastoma 20 58 70
Ovarian Gynandroblastoma 20 17 70

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 D39.1 D40.1
UMLS via Orphanet 71 C0018413
Orphanet 58 ORPHA99914
UMLS 70 C0018413 C0346178

Summaries for Gynandroblastoma

MalaCards based summary : Gynandroblastoma, also known as ovarian gynandroblastoma, is related to sertoli-leydig cell tumor and juvenile type testicular granulosa cell tumor. An important gene associated with Gynandroblastoma is DICER1 (Dicer 1, Ribonuclease III). Affiliated tissues include ovary and testis, and related phenotype is normal.

Wikipedia : 73 Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and... more...

Related Diseases for Gynandroblastoma

Diseases related to Gynandroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 sertoli-leydig cell tumor 30.2 DICER1 CALB2
2 juvenile type testicular granulosa cell tumor 29.6 FOXL2 DICER1 CALB2
3 granulosa cell tumor of the ovary 29.5 VIM FOXL2
4 leydig cell tumor 10.2
5 amenorrhea 10.1
6 pleuropulmonary blastoma 10.0
7 ovary adenocarcinoma 10.0
8 dicer1 tumor predisposition 10.0
9 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 10.0
10 rare tumor 10.0
11 nephroma 10.0 VIM DICER1
12 liver fibroma 9.9 VIM CALB2
13 fibroma 9.9 VIM CALB2
14 pericardial mesothelioma 9.9 VIM CALB2
15 monophasic synovial sarcoma 9.9 VIM CALB2
16 adenomatoid tumor 9.9 VIM CALB2
17 adenofibroma 9.9 VIM CALB2
18 sarcomatoid mesothelioma 9.9 VIM CALB2
19 olfactory neuroblastoma 9.9 VIM CALB2
20 glomus tumor 9.9 VIM CALB2
21 granular cell tumor 9.9 VIM CALB2
22 sertoli cell tumor 9.9 VIM CALB2
23 benign mesothelioma 9.9 VIM CALB2
24 epithelioid sarcoma 9.9 VIM CALB2
25 pneumothorax 9.9 VIM CALB2
26 neurilemmoma 9.9 VIM CALB2
27 pleural disease 9.9 DICER1 CALB2
28 maligant granulosa cell tumor of the ovary 9.9 FOXL2 DICER1
29 microcystic stromal tumor 9.8 FOXL2 DICER1
30 renal cell carcinoma, nonpapillary 9.8
31 mccune-albright syndrome 9.8
32 androgen insensitivity syndrome 9.8
33 fragile x syndrome 9.8
34 endometrial hyperplasia 9.8
35 polycystic ovary syndrome 9.8
36 hyperandrogenism 9.8
37 leiomyoma 9.8
38 hermaphroditism 9.8
39 hypertrichosis 9.8
40 embryoma 9.8
41 ovarian cyst 9.8
42 vulvar leiomyoma 9.8
43 infertility 9.8
44 posttransplant acute limbic encephalitis 9.8
45 carcinosarcoma 9.8 VIM CALB2
46 angiosarcoma 9.8 VIM CALB2
47 liposarcoma 9.8 VIM CALB2
48 adult type testicular granulosa cell tumor 9.8 FOXL2 CALB2
49 luteoma 9.8 FOXL2 CALB2
50 adrenal cortical carcinoma 9.8 VIM CALB2

Graphical network of the top 20 diseases related to Gynandroblastoma:



Diseases related to Gynandroblastoma

Symptoms & Phenotypes for Gynandroblastoma

MGI Mouse Phenotypes related to Gynandroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 8.92 CALB2 DICER1 FOXL2 VIM

Drugs & Therapeutics for Gynandroblastoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Gynandroblastoma

Genetic Tests for Gynandroblastoma

Anatomical Context for Gynandroblastoma

MalaCards organs/tissues related to Gynandroblastoma:

40
Ovary, Testis

Publications for Gynandroblastoma

Articles related to Gynandroblastoma:

(show top 50) (show all 70)
# Title Authors PMID Year
1
Rare DICER1 and Absent FOXL2 Mutations Characterize Ovarian Juvenile Granulosa Cell Tumors. 61
32910017 2021
2
Sertoli-Leydig Cell Tumors of the Ovary With Follicular Differentiation Often Resembling Juvenile Granulosa Cell Tumor: A Report of 38 Cases Including Comments on Sex Cord-Stromal Tumors of Mixed Forms (So-called Gynandroblastoma). 61
32815828 2021
3
Evaluation of molecular analysis in challenging ovarian sex cord-stromal tumours: a review of 50 cases. 61
32782216 2020
4
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman. 61
32751726 2020
5
DICER1 Syndrome and Cancer Predisposition: From a Rare Pediatric Tumor to Lifetime Risk. 61
33552988 2020
6
Ovarian Gynandroblastoma with a Juvenile Granulosa Cell Tumor Component in a Postmenopausal Woman: A Case Report and Literature Review. 61
30011982 2018
7
DICER1 hot-spot mutations in ovarian gynandroblastoma. 61
29660837 2018
8
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. 61
29037807 2017
9
Gynandroblastoma with a Juvenile Granulosa Cell Component in an Adolescent: Case Report and Literature Review. 61
27751908 2017
10
Gynandroblastoma of postmenopausal women: a case report. 61
29894091 2016
11
A survey of DICER1 hotspot mutations in ovarian and testicular sex cord-stromal tumors. 61
26428316 2015
12
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. 61
26169919 2015
13
Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. 61
26054417 2015
14
[A case of gynandroblastoma in a 16-year old girl and review of literature]. 61
25909131 2015
15
[A twelve-years-old girl with multiloculated gynandroblastoma CD99 negative: case report]. 61
24955913 2014
16
DICER1 Tumor Predisposition 61
24761742 2014
17
Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature. 61
24439718 2014
18
Gynandroblastoma: a rare ovarian tumour with an unusual clinical presentation. 61
25935975 2014
19
[A case of gynandroblastoma in a 16-year old girl and review of literature]. 61
25509647 2014
20
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. 61
23552209 2013
21
The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour. 61
22296244 2012
22
Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry. 61
21501861 2011
23
[Gynandroblastoma and Fragile X syndrome. Case report]. 61
21354848 2011
24
Gynandroblastoma with the symptoms of infertility and secondary amenorrhea: a case report. 61
22268290 2011
25
[Ovarian ginandroblastoma as a transcesarean incidental finding. A case report and literature review]. 61
21966775 2010
26
[46, XY hermaphroditism and gynandroblastoma: report of a case]. 61
20654129 2010
27
Gynandroblastoma. Report of an unusual ovarian tumour and literature review. 61
18686520 2008
28
[Gynandroblastoma: a rare ovarian tumour. Case report]. 61
17293152 2007
29
Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis. 61
17197894 2007
30
A cystic mass in a young woman with presumed polycystic ovarian syndrome. Gynandroblastoma. 61
16454570 2006
31
Ovarian gynandroblastoma with juvenile granulosa cell component and raised alpha fetoprotein. 61
16194833 2005
32
Gynandroblastoma of the testis in an infant: a morphological, immunohistochemical and in-situ hybridization report. 61
11943029 2002
33
Gynandroblastoma in pregnancy: case report and review of literature. 61
9757751 1998
34
Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. 61
9688187 1998
35
Gynandroblastoma with elements of juvenile granulosa cell tumor. 61
9553819 1998
36
Gynandroblastoma with elements resembling juvenile granulosa cell tumor. 61
9421080 1997
37
Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. 61
9253627 1997
38
Gynandroblastoma of the ovary: a case report with an immunohistochemical and ultrastructural study. 61
9037319 1997
39
Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands. 61
8884354 1996
40
[Two case of androgen-secreting ovary tumor]. 61
8575058 1995
41
Histogenetic consideration of ovarian sex cord-stromal tumors analyzed by expression pattern of cytokeratins, vimentin, and laminin. Correlation studies with human gonads. 61
7527534 1994
42
Hormonally Active Organ Tumors in Children and Adolescents. 61
10358266 1994
43
[Gynandroblastoma of the ovary. Review of the literature]. 61
8051366 1994
44
[Gynandroblastoma]. 61
7757726 1993
45
Gynandroblastoma of the ovary having a typical morphological appearance: a case study. 61
2067122 1991
46
Gynandroblastoma of the ovary. A case report. 61
1879200 1991
47
Gynandroblastoma of the ovary. 61
3785986 1986
48
Granulosa cell tumor of the ovary with Sertoli-Leydig cell tumor components (gynandroblastoma). 61
4056537 1985
49
Gynandroblastoma of the ovary. 61
6224079 1983
50
Gynandroblastoma: its ultrastructure. 61
6284338 1982

Variations for Gynandroblastoma

Expression for Gynandroblastoma

Search GEO for disease gene expression data for Gynandroblastoma.

Pathways for Gynandroblastoma

GO Terms for Gynandroblastoma

Biological processes related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic DNA fragmentation GO:0006309 8.62 FOXL2 DICER1

Molecular functions related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 8.62 VIM DICER1

Sources for Gynandroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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