MCID: GYN003
MIFTS: 28

Gynandroblastoma

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Gynandroblastoma

Summaries for Gynandroblastoma

MalaCards based summary : Gynandroblastoma, also known as ovarian gynandroblastoma, is related to juvenile type testicular granulosa cell tumor and sertoli-leydig cell tumor. An important gene associated with Gynandroblastoma is DICER1 (Dicer 1, Ribonuclease III). The drugs Paclitaxel and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and endothelial.

Related Diseases for Gynandroblastoma

Graphical network of the top 20 diseases related to Gynandroblastoma:



Diseases related to Gynandroblastoma

Symptoms & Phenotypes for Gynandroblastoma

Drugs & Therapeutics for Gynandroblastoma

Drugs for Gynandroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
6
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
7 Mitogens Phase 2
8 Albumin-Bound Paclitaxel Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Endothelial Growth Factors Phase 2
12 Immunoglobulin G Phase 2
13 Antibodies Phase 2
14 Immunoglobulins Phase 2
15 Antibodies, Monoclonal Phase 2
16 Antimitotic Agents Phase 2
17 Antineoplastic Agents, Phytogenic Phase 2
18 Topoisomerase Inhibitors Phase 2
19 Anti-Bacterial Agents Phase 2
20 Antibiotics, Antitubercular Phase 2
21 Etoposide phosphate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Completed NCT00748657 Phase 2
3 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
4 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Gynandroblastoma

Genetic Tests for Gynandroblastoma

Anatomical Context for Gynandroblastoma

MalaCards organs/tissues related to Gynandroblastoma:

41
Ovary, Testis, Endothelial

Publications for Gynandroblastoma

Articles related to Gynandroblastoma:

(show all 40)
# Title Authors Year
1
DICER1 hot-spot mutations in ovarian gynandroblastoma. ( 29660837 )
2018
2
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
3
Gynandroblastoma with a Juvenile Granulosa Cell Component in an Adolescent: Case Report and Literature Review. ( 27751908 )
2016
4
Gynandroblastoma of postmenopausal women: a case report. ( 29894091 )
2016
5
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. ( 26169919 )
2015
6
Gynandroblastoma: a rare ovarian tumour with an unusual clinical presentation. ( 25935975 )
2014
7
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. ( 23552209 )
2013
8
The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour. ( 22296244 )
2012
9
Gynandroblastoma with the symptoms of infertility and secondary amenorrhea: a case report. ( 22268290 )
2011
10
Gynandroblastoma. Report of an unusual ovarian tumour and literature review. ( 18686520 )
2008
11
Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis. ( 17197894 )
2007
12
A cystic mass in a young woman with presumed polycystic ovarian syndrome. Gynandroblastoma. ( 16454570 )
2006
13
Ovarian gynandroblastoma with juvenile granulosa cell component and raised alpha fetoprotein. ( 16194833 )
2005
14
Gynandroblastoma of the testis in an infant: a morphological, immunohistochemical and in-situ hybridization report. ( 11943029 )
2002
15
Gynandroblastoma in pregnancy: case report and review of literature. ( 9757751 )
1998
16
Gynandroblastoma with elements of juvenile granulosa cell tumor. ( 9553819 )
1998
17
Gynandroblastoma with elements resembling juvenile granulosa cell tumor. ( 9421080 )
1997
18
Gynandroblastoma of the ovary: a case report with an immunohistochemical and ultrastructural study. ( 9037319 )
1997
19
Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands. ( 8884354 )
1996
20
Gynandroblastoma of the ovary having a typical morphological appearance: a case study. ( 2067122 )
1991
21
Gynandroblastoma of the ovary. A case report. ( 1879200 )
1991
22
Gynandroblastoma of the ovary. ( 3785986 )
1986
23
Granulosa cell tumor of the ovary with Sertoli-Leydig cell tumor components (gynandroblastoma). ( 4056537 )
1985
24
Gynandroblastoma of the ovary. ( 6224079 )
1983
25
Gynandroblastoma: its ultrastructure. ( 6284338 )
1982
26
Hormone studies in a gynandroblastoma. ( 658481 )
1978
27
Gynandroblastoma of the ovary. ( 1169960 )
1975
28
Gynandroblastoma of the ovary. ( 4846779 )
1974
29
Ovarian gynandroblastoma presenting with primary amenorrhea. ( 4744425 )
1973
30
Plasma steroids in two subjects with ovarian androgen-producing tumors arrhenoblastoma and gynandroblastoma. ( 4334770 )
1972
31
Spontaneous rupture of gynandroblastoma during labor. Report of a case. ( 5474001 )
1970
32
Gynandroblastoma of the ovary: review of 8 cases from the ovarian tumor registry. ( 4293230 )
1967
33
Pleomorphic granulosa-cell tumor. A borderline case resembling gynandroblastoma. ( 6017934 )
1967
34
GYNANDROBLASTOMA. REPORT OF A CASE FOLLOWED BY VAGINAL CYTOLOGY. ( 14085616 )
1963
35
Gynandroblastoma. A report of five cases, with a discussion of the histogenesis and classification of ovarian tumors. ( 14479145 )
1962
36
Case report of gynandroblastoma. ( 13606189 )
1959
37
Gynandroblastoma of the ovary; review and report of a case. ( 13633117 )
1959
38
Feminizing ovarian gynandroblastoma. ( 13627065 )
1959
39
Gynandroblastoma of the ovary. ( 18103140 )
1949
40
Gynandroblastoma of the Ovary. ( 19970711 )
1943

Variations for Gynandroblastoma

Expression for Gynandroblastoma

Search GEO for disease gene expression data for Gynandroblastoma.

Pathways for Gynandroblastoma

GO Terms for Gynandroblastoma

Biological processes related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic DNA fragmentation GO:0006309 8.62 DICER1 FOXL2

Molecular functions related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 8.96 DICER1 VIM
2 double-stranded RNA binding GO:0003725 8.62 DICER1 VIM

Sources for Gynandroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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