MCID: GYN002
MIFTS: 21

Gynatresia

Categories: Reproductive diseases

Aliases & Classifications for Gynatresia

MalaCards integrated aliases for Gynatresia:

Name: Gynatresia 12 43 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:429
MeSH 43 D006175
NCIt 49 C84743
UMLS 71 C0018414

Summaries for Gynatresia

Disease Ontology : 12 A female reproductive system disease that is characterized by the occlusion of some part of the female genital tract, especially occlusion of the vagina.

MalaCards based summary : Gynatresia is related to hemometra and renal hypodysplasia/aplasia 1. An important gene associated with Gynatresia is THEM5 (Thioesterase Superfamily Member 5). The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and bone marrow.

Related Diseases for Gynatresia

Diseases related to Gynatresia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 hemometra 10.3
2 renal hypodysplasia/aplasia 1 10.2
3 amenorrhea 10.2
4 impotence 10.2
5 vaginitis 10.2
6 infertility 10.2
7 septate vagina 10.2

Graphical network of the top 20 diseases related to Gynatresia:



Diseases related to Gynatresia

Symptoms & Phenotypes for Gynatresia

Drugs & Therapeutics for Gynatresia

Drugs for Gynatresia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 4 28014-46-2
3 Estradiol 17 beta-cypionate Phase 4
4 Estradiol 3-benzoate Phase 4
5 Estrogens Phase 4
6 Contraceptive Agents Phase 4
7 Progestins Phase 4
8 Hormone Antagonists Phase 4
9 Hormones Phase 4
10
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
11 Anesthetics Phase 2
12 Anti-Bacterial Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14
Sargramostim Approved, Investigational 83869-56-1, 123774-72-1
15
carbamide peroxide Approved 124-43-6

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 New Therapeutic Approaches to Treat Asherman's Syndrome and Endometrial Atrophy Based in BM Stem Cells Autologous Transplantation Completed NCT02144987 Phase 4
2 The Effect of Estrogen in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis Enrolling by invitation NCT03620929 Phase 4 Estradiol Valerate
3 Non-stick Gel Applicated After Scraping Surgery for Natural Miscarriage and Uterine Synechiae Prevention Active, not recruiting NCT02248376 Phase 3 Gel
4 A Multi-center, Randomized, Single-blind, Controlled Clinical Trial of Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells Unknown status NCT02680366 Phase 2
5 A Prospective, Randomized, Controlled Trial Comparing 2 Different Doses of Estrogen Therapy After Hysteroscopic Adhesiolysis as an Adjuvant to Prevent Recurrence of Intrauterine Adhesions Completed NCT02726971 Phase 1, Phase 2 Femoston
6 Platelet-Rich Plasma in the Management of Asherman Syndrome Completed NCT04308811 Phase 2
7 Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair: a Prospective Randomised Pilot Study Completed NCT02825849 Phase 2
8 Open Randomized Trial of Clinical Efficiency and Safety of Cell Product of Autologous Bone Marrow-derived Mesenchymal Stem Cells for Reparative Treatment of Destructively Changed Endometrium in Patients With Repeated IVF Failures Completed NCT03166189 Phase 2
9 Fertility Restoration Using Autologous Adipose Tissue Derived Mesenchymal Stem Cells Not yet recruiting NCT04432467 Phase 1, Phase 2
10 Safety and Therapeutic Effect of Human Amniotic Epithelial Cells in Severe Refractory Asherman's Syndrome Not yet recruiting NCT03223454 Phase 1
11 Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery - a Prospective Double Blind Randomized Study Unknown status NCT01637974 INTERCOAT administration
12 MONOBISY: Randomized Controlled Trial Comparing Intra Uterine Synechiae Occurence Using Bipolar Energy Compared With Monopolar Energy in Myoma Resection on Women Having Menorraghia and/or Infertility Unknown status NCT02661087
13 Intercoat (Oxiplex/AP Gel) for Preventing Intrauterine Adhesions Following Operative Hysteroscopy for Suspected Retained Products of Conception - a Prospective Randomized Pilot Study Completed NCT01377779 Oxiplex/AP gel;Normal Saline
14 Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and Quality of Life in Women With Intrauterine Adhesion:a Randomized Controlled Trial. Completed NCT02746679
15 Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Infertility Due to Severe Intrauterine Adhesions. Completed NCT02708277
16 A Randomized Clinical Trial to Assess the Efficacy of Intrauterine Balloon Compared to Intrauterine Contraceptive Device Plus Foley Catheter in the Therapy for Uterine Adhesion After Hysteroscopic Adhesiolysis Completed NCT02867202
17 Endometrial Reconstruction by Human Regenerative Factors Derived From Platelet-Rich Plasma in Mice Models Recruiting NCT03249415
18 Biomedical Study of Toxicity, Biodistribution, Expression and Cellular Characterization of Autologous CD133+ Stem Cells From Donors of Hematopoietic Progenitors (IGX1) in Murine Model With Asherman-induced Syndrome. Recruiting NCT03665649
19 Effects of Intrauterine Platelet Rich Plasma (PRP) on Endometrium and Pregnancy Rates in Patients With Suboptimal Endometrium Undergoing Frozen Embryo Transfer Not yet recruiting NCT04424160

Search NIH Clinical Center for Gynatresia

Cochrane evidence based reviews: gynatresia

Genetic Tests for Gynatresia

Anatomical Context for Gynatresia

MalaCards organs/tissues related to Gynatresia:

40
Bone, Uterus, Bone Marrow, Kidney

Publications for Gynatresia

Articles related to Gynatresia:

(show all 41)
# Title Authors PMID Year
1
Successful pregnancy following acquired gynatresia. 61
31070154 2019
2
[Acquired vaginal stenosis: about a case and literature review]. 61
32153715 2019
3
Case report of treatment with a sigmoid neovagina for a patient with vesicovaginal fistula and gynatresia. 61
29072881 2018
4
Acquired gynatresia. 61
24777085 2014
5
[Successful full-term pregnancy in the Herlyn-Werner-Wunderlich syndrome: a case report and review of literature]. 61
25510053 2014
6
The epidemiology and management of gynatresia in Lagos, southwest Nigeria. 61
22717415 2012
7
Pudendal thigh flap in the treatment of acquired gynatresia from caustic pessaries. 61
21767838 2011
8
Complications of treatment of obstetric fistula in the developing world: gynatresia, urinary incontinence, and urinary diversion. 61
17803995 2007
9
Surgery for the obstetric vesicovaginal fistula: a review of 100 operations in 82 patients. 61
8166194 1994
10
A study of urinary fistulae in Sokoto, Nigeria. 61
1287094 1992
11
[Use of echography in the diagnosis of gynatresia in girls]. 61
3327388 1987
12
The challenges of vaginal atresia and stenosis: Nigerian experience. 61
6144585 1984
13
Reproductive performance after the repair of obstetric vesico-vaginal fistulae. 61
742828 1978
14
Ultrasound diagnosis of hematocervix following gynatresia in a case of uterus bicornis bicollis. 61
39847 1978
15
[Inhibition malformation of the female genitaltract combined with gynatresia on one side (author's transl)]. 61
144662 1977
16
[The primary isolated ovarian abscess. Clinical and bacteriological observations and a new pathogenetic hypothesis (author's transl)]. 61
885336 1977
17
Acquired gynaetresia in Ibadan. 61
16296140 1976
18
[Unilateral gynatresia associated with duplication of the female genitalia]. 61
4697115 1973
19
[Unilateral hymenal gynatresia in uterus bicornis bicollis]. 61
4697117 1973
20
[Symptomatology of unilateral gynatresia associated with double uterus and septate vagina as well as with aplasia of the ipsilateral kidney and regular menstruation from the contralateral genital primordium (case report)]. 61
5147284 1971
21
Congenital gynatresia. 61
6039400 1967
22
[An unusual case of gynatresia in an infant]. 61
6001407 1966
23
Double uteri in gynecologic practice. Report of 6 cases, including gynatresia with subsequent pregnancy. 61
5874265 1965
24
[CONTRIBUTION TO THE SYMPTOMOLOGY AND TREATMENT OF GYNATRESIA WITH HEMOSALPINX]. 61
14238461 1964
25
[ON 7 CASES OF GYNATRESIA]. 61
14138139 1964
26
[UNILATERAL RENAL AGENESIS ASSOCIATED WITH HOMOLATERAL GYNATRESIA AND DOUBLE UTERUS]. 61
14140687 1964
27
[A case of hemi-gynatresia in a 12-year-old girl]. 61
13900016 1962
28
[Pregnancy and spontaneous labor following surgical therapy of congenital gynatresia]. 61
14456374 1962
29
Unusual forms of gynatresia. 61
13764726 1960
30
[Congenital gynatresia caused by septation of the middle third of the vagina]. 61
13486171 1957
31
[Incomplete vaginal gynatresia & sterility; case report]. 61
13419226 1956
32
[Vaginal gynatresia and pregnancy]. 61
13388194 1956
33
[Two cases of gynatresia]. 61
13344969 1956
34
[Incomplete gynatresia of the vagina and infertility]. 61
14394538 1955
35
[Considerations on a case of Gynatresia]. 61
13204759 1953
36
[Gynatresia]. 61
13072898 1953
37
Hematometra following postpartum gynatresia in a uterus septate duplex with a single vagina. 61
14785848 1950
38
A Case of Uterus Didelphys with Unilateral Gynatresia. 61
20787851 1950
39
Gynatresia; report of three uncommon clinical types. 61
18882986 1948
40
Gynatresia with Torsion of Right Adnexae: Report of Case. 61
18745258 1939
41
GYNATRESIA. 61
20321221 1939

Variations for Gynatresia

Expression for Gynatresia

Search GEO for disease gene expression data for Gynatresia.

Pathways for Gynatresia

GO Terms for Gynatresia

Sources for Gynatresia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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