Gynecomastia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A disorder of sexual development that is characterized by enlargement or swelling of male breast tissue resulting from elevated male estrogen levels or imbalanced estrogen and testosterone levels.

MalaCards based summary: Gynecomastia is related to 17-beta hydroxysteroid dehydrogenase iii deficiency and androgen insensitivity, partial. An important gene associated with Gynecomastia is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Metabolism of proteins and Signal Transduction. The drugs Anastrozole and (R)-Bicalutamide have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and testis, and related phenotypes are homeostasis/metabolism and nervous system

Wikipedia: ⁷⁵ Gynecomastia (also spelled gynaecomastia)[a] is the abnormal non-cancerous enlargement of one or both... more...

Sources

Related Diseases for Gynecomastia

Diseases related to Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 610)

#	Related Disease	Score	Top Affiliating Genes
1	17-beta hydroxysteroid dehydrogenase iii deficiency	32.3	POMC HSD17B3 GNRH1 AR
2	androgen insensitivity, partial	31.8	SRD5A1 SHBG HSD17B3 CYP19A1 AR
3	aromatase excess syndrome	31.7	SHBG POMC PGR GNRH1 ESR2 ESR1
4	androgen insensitivity syndrome	31.2	SRY SRD5A1 SHBG HSD17B3 CGA AR
5	hypogonadotropic hypogonadism	30.9	SHBG PRL POMC INHA HSD17B3 GNRH1
6	hyperthyroidism	30.7	SHBG PRL POMC CGA
7	sertoli cell tumor	30.5	PGR INHA CYP19A1 AR
8	ductal carcinoma in situ	30.5	PGR ESR2 ESR1 ERBB2 CYP19A1 AR
9	benign breast phyllodes tumor	30.5	PGR ESR1
10	leydig cell tumor	30.4	PRL INHA GNRH1 ESR1 CYP19A1
11	hypertrophy of breast	30.4	PGR ESR1 ERBB2 CYP19A1
12	breast fibroadenoma	30.3	PGR ESR1 ERBB2 AR
13	breast malignant phyllodes tumor	30.3	PGR ESR1 ERBB2
14	intraductal papilloma	30.3	PGR ESR1 ERBB2
15	bilateral breast cancer	30.3	PGR ESR1 ERBB2 CYP19A1
16	hypospadias	30.3	SRY SRD5A1 HSD17B3 ESR2 ESR1 AR
17	choriocarcinoma	30.2	INHA CYP19A1 CGB5 CGA
18	turner syndrome	30.2	SRY SHBG AR
19	prostatic hyperplasia, benign	30.2	SRD5A1 KLK3 AR
20	hyperprolactinemia	30.2	SHBG PRL POMC GNRH1 CGA
21	hypogonadism	30.2	SHBG PRL POMC PHF6 KLK3 GNRH1
22	testicular cancer	30.2	SHBG KLK3 GNRH1 ESR1 CGB5 CGA
23	alopecia	30.1	SRD5A1 SHBG PRL CYP19A1 AR
24	adrenal cortical carcinoma	30.1	POMC INHA ESR1 ERBB2 CYP19A1
25	impotence	30.1	SRD5A1 SHBG PRL KLK3 CYP3A4 AR
26	mammary paget's disease	30.1	PGR ESR1 ERBB2 AR
27	prostatic hypertrophy	30.0	SHBG KLK3 ESR1 AR
28	teratoma	30.0	ESR1 ERBB2 CGB5 CGA
29	seminoma	30.0	INHA ESR2 ESR1 CGB5 CGA
30	testicular germ cell cancer	30.0	ESR2 ESR1 AR
31	nipple carcinoma	30.0	PGR ESR1 ERBB2
32	breast disease	29.9	SHBG PRL PGR KLK3 ESR2 ESR1
33	acne	29.9	SRD5A1 SHBG PRL POMC CYP19A1 AR
34	oligospermia	29.9	PRL GNRH1 AR
35	germ cell cancer	29.9	ESR2 CGA AR
36	estrogen excess	29.8	SHBG PRL PGR GNRH1 ESR2 ESR1
37	lobular neoplasia	29.8	PGR ESR1 ERBB2 CYP19A1
38	apocrine adenocarcinoma	29.8	PGR ESR1 ERBB2 AR
39	sweat gland cancer	29.8	PGR ESR1 ERBB2 AR
40	alopecia, androgenetic, 1	29.8	SRD5A1 SHBG CYP19A1 AR
41	pituitary-dependent cushing's disease	29.8	PRL POMC
42	prostate disease	29.8	SRD5A1 KLK3 CYP19A1 AR
43	gonadal dysgenesis	29.8	SRY SHBG CGB5
44	pseudohermaphroditism	29.8	SRY SRD5A1 POMC HSD17B3 GNRH1 CYP19A1
45	androgenic alopecia	29.7	SRD5A1 SHBG PRL CYP19A1 AR
46	breast adenocarcinoma	29.7	PGR ESR2 ESR1 ERBB2 CYP19A1
47	female breast cancer	29.7	PGR KLK3 ESR2 ESR1 ERBB2 CYP19A1
48	hypopituitarism	29.6	SHBG PRL POMC GNRH1
49	pituitary gland disease	29.6	PRL POMC GNRH1 CGA
50	varicocele	29.6	SHBG PRL GNRH1 ESR1 CGA AR

Graphical network of the top 20 diseases related to Gynecomastia:

Sources

Symptoms & Phenotypes for Gynecomastia

MGI Mouse Phenotypes related to Gynecomastia:

⁴⁵ (show all 14)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.33	AR CGA CGB5 CYP19A1 CYP3A4 ERBB2
2	nervous system	MP:0003631	10.29	AR CGA CYP19A1 ERBB2 ESR1 ESR2
3	neoplasm	MP:0002006	10.24	AR ERBB2 ESR1 ESR2 GNRH1 INHA
4	normal	MP:0002873	10.22	AR CYP19A1 CYP3A4 ERBB2 ESR1 ESR2
5	endocrine/exocrine gland	MP:0005379	10.22	AR CGA CGB5 CYP19A1 ERBB2 ESR1
6	growth/size/body region	MP:0005378	10.18	AR CGA CGB5 CYP19A1 ERBB2 ESR1
7	muscle	MP:0005369	10.13	AR CYP19A1 ERBB2 ESR1 ESR2 HSD17B3
8	renal/urinary system	MP:0005367	10.1	AR CYP19A1 ESR1 ESR2 GNRH1 HSD17B3
9	liver/biliary system	MP:0005370	10.06	AR CYP19A1 ESR1 ESR2 GNRH1 INHA
10	reproductive system	MP:0005389	10.03	AR CGA CGB5 CYP19A1 ERBB2 ESR1
11	adipose tissue	MP:0005375	9.98	AR CYP19A1 ESR1 ESR2 HSD17B3 PHF6
12	digestive/alimentary	MP:0005381	9.86	AR CYP19A1 ERBB2 ESR1 ESR2 GNRH1
13	hematopoietic system	MP:0005397	9.73	AR CYP19A1 ERBB2 ESR1 ESR2 GNRH1
14	integument	MP:0010771	9.28	AR CYP19A1 ERBB2 ESR1 ESR2 GNRH1

Sources

Drugs & Therapeutics for Gynecomastia

Drugs for Gynecomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Anastrozole

Approved, Investigational

Phase 3

120511-73-1

2187

2

(R)-Bicalutamide

Approved, Experimental

Phase 3

90357-06-5, 113299-40-4

2375

3

Tamoxifen

Approved

Phase 3

10540-29-1, 54965-24-1

2733526

4

Antineoplastic Agents, Hormonal

Phase 3

5

Estrogens

Phase 3

6

Estrogen Receptor Antagonists

Phase 3

7

Estrogen Antagonists

Phase 3

8

Hormones

Phase 3

9

Hormone Antagonists

Phase 3

10

Aromatase Inhibitors

Phase 3

11

Estrogen Receptor Modulators

Phase 3

12

Androgens

Phase 3

13

Androgen Antagonists

Phase 3

14

Selective Estrogen Receptor Modulators

Phase 3

15

Dexamethasone acetate

Approved, Investigational, Vet_approved

1177-87-3

3680

16

Dexamethasone

Approved, Investigational, Vet_approved

50-02-2

3003 5743

Synonyms:

[<sup>3</sup>H]-dexamethasone

16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol

16alpha -Methyl-9alpha -fluoroprednisolone

16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol

16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol

16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone

16alpha-Methyl-9alpha-fluoroprednisolone

16-alpha-Methyl-9-alpha-fluoroprednisolone

16a-Methyl-9a-fluoro-1-dehydrocortisol

16Α-methyl-9α-fluoro-1-dehydrocortisol

1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone

1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone

1-Dehydro-16a-methyl-9a-fluorohydrocortisone

1-Dehydro-16α-methyl-9α-fluorohydrocortisone

9a-Fluoro-16a-methylprednisolone

9a-Fluoro-16BETA-methylprednisolone

9alpha -Fluoro-16alpha -methylprednisolone

9alpha-Fluoro-16alpha-methylprednisolone

9alpha-Fluoro-16alpha-methyl-prednisolone

9-alpha-Fluoro-16-alpha-methylprednisolone

9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione

9-Fluoro-16-methylprednisolone

9Α-fluoro-16α-methylprednisolone

Adexone

Aeroseb-D

Aeroseb-dex

Ak dex OPH otic soln 0.1%

Alcon brand OF dexamethasone

alpha -Fluoro-16-alpha -methylcortisol

Anaflogistico

Aphtasolon

Aphthasolone

Apo-dexamethasone

Auxiron

Azimycin (veterinary)

Azium

Azium (veterinary)

Bisu DS

Calonat

Corson

Corsone

Cortisumman

DALALONE

Decacort

Decacortin

Decaderm

Decadron

Decadron Tablets, Elixir

Decadron®|desametasone|fluormethylprednisolone

DECADRON-75

DECADRON-LA

Decagel

Decaject

Decaject l.a.

Decaject-l.a.

Decalix

Decameth

Decasone

Decaspray

Dectancyl

Dekacort

Delta1-9alpha-Fluoro-16alpha-methylcortisol

Deltafluorene

Dergramin

Deronil

Desadrene

Desametasone

Desametasone [Dcit]

Desamethasone

Desameton

Deseronil

DEX

DEXA

Dexa mamallet

DEXACEN-4

Dexacidin

Dexacort

Dexacortal

Dexa-cortidelt

Dexacortin

Dexa-cortisyl

DEXACORTISYL

Dexadeltone

Dexafarma

DEXAFREE

DEXAIR

Dexalona

Dexaltin

Dexa-Mamallet

Dexametasona

Dexametasona [INN-Spanish]

Dexametasone

Dexameth

Dexamethansone

DEXAMETHASONE

Dexaméthasone

Dexamethasone acetate

Dexamethasone alcohol

Dexamethasone base

Dexamethasone intensol

DEXAMETHASONE METASULFOBENZOATE SODIUM

DEXAMETHASONE PALMITATE

Dexamethasone sodium phosphate

DEXAMETHASONE VALERATE

Dexamethasone-omega

Dexamethasonum

Dexamethasonum [INN-Latin]

Dexamethazone

Dexamonozon

Dexapolcort

Dexapos

Dexaprol

Dexa-scheroson

Dexa-sine

Dexason

Dexasone

Dexasone 0.5MG

Dexasone 0.75MG

Dexasone 4MG

Dexasporin

Dex-ide

Dexinolon

Dexinoral

Dexone

DEXONE 0.5

DEXONE 0.75

DEXONE 1.5

DEXONE 4

Dexonium

Dexpak

DEXSOL

Dextelan

DEXTENZA

DEXYCU KIT

Dezone

Dinormon

DROPODEX

DXM

DXM833

DXMS

ECR brand OF dexamethasone

Fluormethylprednisolone

Fluormone

Fluorocort

Fortecortin

Foy brand OF dexamethasone

Gammacorten

GPPE EAR SPY

Hexadecadrol

Hexadrol

Hexadrol elixir

Hexadrol Tablets

HL-Dex

ICN brand OF dexamethasone

IontoDex

Isopto-dex

ISV-305

KORTICO INJECTION

Lokalison F

Loverine

Luxazone

MARTAPAN

Maxidex

Maxidex ont 0.1%

Maxidex sus 0.1%

Maxitrol

Mediamethasone

Merck brand OF dexamethasone

Merz brand 1 OF dexamethasone

Merz brand 2 OF dexamethasone

Methylfluorprednisolone

Mexidex

Millicorten

Mymethasone

Naquasone (veterinary)

NEODECADRON

Neomycin and polymyxin b sulfates and dexamethasone

Neomycin and polymyxin b sulphates and dexamethasone

NSC 34521

NSC-34521

Ocu-trol

Oradexon

OTO-104

OTOMIZE

OZURDEX

Pet derm III

Pet-Derm Iii

PHL-Dexamethasone

PMS Dexamethasone elixir 0.5mg/5ML

PMS-Dexamethasone

Policort

Posurdex

Prednisolon F

Prednisolone F

Prodex

Sandoz dexamethasone

SK-Dexamethasone

SOFRADEX

SPERSADEX COMP

Spoloven

Sunia sol D

Superprednol

Tobradex

Tobramycin and dexamethasone

Tresaderm (veterinary)

Turbinaire

Visumetazone

17

Bupivacaine

Approved, Investigational

2180-92-9, 38396-39-3

2474

18

Racepinephrine

Approved, Vet_approved

51-43-4, 329-65-7

838 5816

Synonyms:

(−)-(R)-epinephrine

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-a-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[(methylamino)methyl]-benzyl alcohol

(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-α-((methylamino)methyl)benzyl alcohol

(-)-Adrenaline

(−)-ADRENALINE

(-)-Epinephrine

(+-)-Adrenaline

(+-)-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(−)-ADRENALINE

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-Adrenaline

(R)-Epinephrine

2-(Methylamino)-1-(3,4-dihydroxyphenyl)ethanol

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL

4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL

Acetate, epinephrine

Adnephrine

ADREN CO

ADRENACLICK

Adrenal

Adrenalin

Adrenaline

Adrénaline

Adrenaline acid tartrate

Adrenaline bitartrate

Adrenaline hydrochloride

Adrenaline hydrochloride, racemic mixture

Adrenaline, racemic

Adrenaline, racemic mixture

adrenaline|epinephrine

Adrenine

Adrin

Allergan brand OF adrenaline hydrochloride

ANA-GUARD

Ana-kit

ANAPEN

ANAPHYLACTIC SHOCK DRUG KIT

ASMA-VYDRIN

ASTHMAHALER

Auvi-Q

Bird brand OF racepinefrine hydrochloride

Bosmin

Bronkaid mist

BROVON

Chelafrin

DL-Adrenaline

EMERADE

EPI E Z PEN JR

Epifrin

Epiglaufrin

Epinefrin

Epinefrina

Epinephran

Epinephrin

EPINEPHRINE

Epinephrine acetate

Epinephrine bitartrate

EPINEPHRINE HCL

Epinephrine hydrochloride

Epinephrine hydrochloride, racemic mixture

Epinephrine hydrogen tartrate

Epinephrine racemic

Epinephrine, racemic

Epinephrine, racemic mixture

Epinephrinum

Epipen

EPIPEN E Z PEN

Epipen JR

EPIPEN JR.

Epirenan

Epitrate

Eppy

Exadrin

Glauposine

GPPE INH SOLN

Hemisine

Hemostasin

Hemostatin

Hydrochloride, racepinephrine

Hypernephrin

Isoptoepinal

JEXT

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-DETHYLAMINOETHANOLCATECHOL

L-Epinephrine

L-Epirenamine

Levoepinephrine

LEVO-METHYLAMINOETHANOLCATECHOL

Levorenen

Levorenin

Levorenine

Levoreninum

L-Methylaminoethanolcatechol

Lyodrin

Lyophrin

Medihaler-epi

Methylarterenol

Micronefrin

Micronephrine

Mixture adrenaline, racemic

Mixture epinephrine, racemic

Mucidrina

Nephridine

Nieraline

NSC-62786

Paranephrin

Primatene

Primatene mist

R-(-)-Epinephrine

Racemic adrenaline

Racemic epinephrine

Racemic mixture adrenaline

Racemic mixture epinephrine

Racepinefrina

Racepinefrine

Racepinefrinum

Racepinephrine

Racepinephrine hydrochloride

Renaglandin

Renaleptine

Renalina

Renoform

Renostypticin

Renostyptin

RIDDOBRON

RIDDOFAN

RYBARVIN

Scurenaline

Simplene

SOLN MADE TO RYBARVIN FOR

Styptirenal

Supracapsulin

Supranephrane

Suprarenaline

Suprarenin

Surrenine

Sus-phrine

SUS-PHRINE SULFITE FREE

SUS-PHRINE SULFITE-FREE

SYMJEPI

Takamina

TWINJECT

TWINJECT 0.15

TWINJECT 0.3

Vaponefrin

Vasoconstrictine

Vasotonin

19

Lidocaine

Approved, Vet_approved

137-58-6

3676

20

Vitamin A

Approved, Nutraceutical, Vet_approved

22737-96-8, 68-26-8

5280382 445354

21

Anesthetics, Local

22

Pharmaceutical Solutions

Early Phase 1

23

Hemostatics

24

Anesthetics

25

Epinephryl borate

26

Retinol palmitate

27

English Lavender

28

Tea Tree

29

Tea

Interventional clinical trials:

(show all 15)

#	Name	Status	NCT ID	Phase	Drugs
1	An OptioExtension of Trial 1033US/0006 to Assess Safety, Tolerability, Efficacy of Anastrozole (ZD1033, Arimidex™) in Treatment of Gynecomastia in Pubertal Boys Given Placebo and to Conduct a Long-Term Safety Follow-Up of Non-Responding Subjects Given Anastrozole in the Previous Trial	Completed	NCT00637182	Phase 3	Anastrozole
2	A Comparative Trial of the Efficacy of Two Different Nolvadex (NDX) Dosing and Scheduling Regimens in Preventing Gynecomastia Induced by Casodex (CDX) 150 Monotherapy in Prostate Cancer Patients. An Open, Multicenter, Phase III Trial.	Completed	NCT00233610	Phase 3	Bicalutamide;Tamoxifen
3	Topical Nitroglycerin as a Mechanism for Cutaneous Vaso-modulation and Improved Wound Healing After Breast Reduction	Withdrawn	NCT04321967	Phase 3	Nitroglycerin Paste;Dermabond
4	An Open-Label Pharmacokinetic and Pharmacodynamic Study of Anastrozole (Arimidex™) Used to Treat Pubertal Boys With Gynecomastia of Recent Onset	Completed	NCT00241436	Phase 2	Anastrozole (ARIMIDEX™)
5	Randomised, Double-blind, Placebo Controlled, Parallel-group, Multicentre Phase II Study to Assess Dose Response Relationship of Nolvadex (Oral Tablet) in Prophylactic Treatment of Gynaecomastia and Breast Pain Associated With CASODEX 150 mg (Oral Tablet), and to Assess the Tumour Control…..	Completed	NCT00637871	Phase 2	Casodex;Tamoxifen
6	Targeted Fat Reduction of Pseudogynecomastia in the Male Breast Using the ZELTIQ Coolsculpting System	Unknown status	NCT01791660
7	Ultrasound Guided Modified Pectoral Plane (PECS II )Block Versus Erector Spinae Plane (ESP) Block for Perioperative Analgesia of Surgical Treatment of Gynecomastia	Completed	NCT04221074
8	Post-massive Weight Loss Chest Contouring: Inferior Pedicle Technique in Pseudo-gynecomastia Correction	Completed	NCT03319862
9	Efficacy of Rhomboid Intercostal Block With Sub-serratus Block on Perioperative Analgesia in Patients Undergoing Gynecomastia Surgery	Completed	NCT04859803	Early Phase 1	patients will receive rhomboid intercostal block under ultrasound guidance.;sham block
10	A Randomized Controlled Trial Modified Benelli Procedure For Subcutaneous Mastectomy In Gynecomastia	Completed	NCT04063722
11	Thoracic Interfascial Plane Block Versus Thoracic Paravertebral Block for Anesthesia in Gynecomastia Surgery: A Randomized Controlled Trial	Recruiting	NCT04425447		Tumescent local anesthesia;Thoracic paravertebral block;Thoracic interfascial plane block
12	Prevalence of Endocrine Disorders Among Children Exposed to Lavender Essential Oil and Tea Tree Essential Oils	Recruiting	NCT04836364
13	A Pilot Study of the Renuvion APR System When Used as an Adjunct Procedure In Gynecomastia Surgery	Active, not recruiting	NCT05093049
14	Comparison Between Liposuction and Peri-areolar Surgical Excision in Mild and Moderate Cases of Gynaecomastia	Active, not recruiting	NCT04966078
15	Clinical Evaluation of the UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia)	Withdrawn	NCT02711605

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Tamoxifen

Tamoxifen Citrate

Sources

Genetic Tests for Gynecomastia

Genetic tests related to Gynecomastia:

#	Genetic test	Affiliating Genes
1	Gynecomastia ²⁸

Sources

Anatomical Context for Gynecomastia

Organs/tissues related to Gynecomastia:

MalaCards : Breast, Prostate, Testis, Pituitary, Heart, Liver, Adrenal Cortex

Sources

Publications for Gynecomastia

Articles related to Gynecomastia:

(show top 50) (show all 3391)

#	Title	Authors	PMID	Year
1	[The use of aromatase inhibitors in children]. ⁵³ ⁶²	Eyal O...Weintrob N	20088436	2009
2	Venlafaxine-induced gynecomastia in a young patient: a case report. ⁵³ ⁶²	Karakurt F...Ozbek M	18978497	2009
3	Mineralocorticoid receptor antagonists and endothelial function. ⁵³ ⁶²	Maron BA...Leopold JA	18729003	2008
4	Gynecomastia in prepubertal and pubertal men. ⁵³ ⁶²	Ma NS...Geffner ME	18622206	2008
5	Effect of hyperprolactinemia during development in children and adolescents. ⁵³ ⁶²	Correll CU	18816151	2008
6	An open label, dose response study to determine the effect of a dietary supplement on dihydrotestosterone, testosterone and estradiol levels in healthy males. ⁵³ ⁶²	Angwafor F...Anderson ML	18700016	2008
7	Association between gynecomastia and aromatase (CYP19) polymorphisms. ⁵³ ⁶²	Czajka-Oraniec I...Ostrowski J	18426832	2008
8	[Phenotype of patients with gynecomastia]. ⁵³ ⁶²	Czajka-Oraniec I...Zgliczynski W	18465688	2008
9	Growth hormone producing prolactinoma in juvenile cystinosis: a simple coincidence? ⁵³ ⁶²	Besouw MT...Noordam K	17638022	2008
10	Clinical implications of antipsychotic-induced hyperprolactinemia in patients with schizophrenia spectrum or bipolar spectrum disorders: recent developments and current perspectives. ⁵³ ⁶²	Byerly M...Baker RA	18004132	2007
11	Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene. ⁵³ ⁶²	Demura M...Bulun SE	17584767	2007
12	Effect of hyperprolactinemia in male patients consulting for sexual dysfunction. ⁵³ ⁶²	Corona G...Maggi M	17655655	2007
13	Gynecomastia: review. ⁵³ ⁶²	Abaci A...Buyukgebiz A	17925790	2007
14	Gynecomastia. ⁵³ ⁶²	Narula HS...Carlson HE	17543732	2007
15	Open-label, prospective trial of olanzapine in adolescents with subaverage intelligence and disruptive behavioral disorders. ⁵³ ⁶²	Handen BL...Hardan AY	16865035	2006
16	Risperidone-induced symptomatic hyperprolactinaemia in adolescents. ⁵³ ⁶²	Holzer L...Eap CB	16633146	2006
17	Prepubertal gynecomastia in Peutz-Jeghers syndrome: incomplete penetrance in a familial case and management with an aromatase inhibitor. ⁵³ ⁶²	Lefevre H...Carel JC	16452534	2006
18	Gynecomastia and breast pain induced by adjuvant therapy with bicalutamide after radical prostatectomy in patients with prostate cancer: the role of tamoxifen and radiotherapy. ⁵³ ⁶²	Di Lorenzo G...Autorino R	16280763	2005
19	[Aromatase-dependent gynecomastia in a patient with adenocarcinoma of the lung]. ⁵³ ⁶²	Gutierrez-Santiago M...Riancho JA	16238933	2005
20	Leptin levels in boys with pubertal gynecomastia. ⁵³ ⁶²	Dundar B...Buyukgebiz A	16355805	2005
21	Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer. ⁵³ ⁶²	Boccardo F...Montefiore F	15681525	2005
22	Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. ⁵³ ⁶²	Kara C...Senel F	15947469	2005
23	Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred. ⁵³ ⁶²	Binder G...Schmidt M	15483104	2005
24	Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. ⁵³ ⁶²	Irahara N...Harada N	16392624	2005
25	The effect of tamoxifen on sex hormone binding globulin in adolescents with pubertal gynecomastia. ⁵³ ⁶²	Derman O...Tokur TE	15379424	2004
26	Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. ⁵³ ⁶²	Lawrence SE...Lawson ML	15238910	2004
27	Gynecomastia due to hormone therapy for advanced prostate cancer: a report of ten surgically treated cases and a review of treatment options. ⁵³ ⁶²	Prezioso D...Lotti T	15510985	2004
28	[Sexual dysfunction among 78 Moroccan male hemodialysis patients: clinical and endocrine study]. ⁵³ ⁶²	Zamd M...Hassan Tahri E	15277975	2004
29	Multiple structural and functional abnormalities in the p450 aromatase expressing transgenic male mice are ameliorated by a p450 aromatase inhibitor. ⁵³ ⁶²	Li X...Poutanen M	14982857	2004
30	Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole. ⁵³ ⁶²	Rhoden EL...Morgentaler A	14963480	2004
31	Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. ⁵³ ⁶²	Bernard-Gallon DJ...Bignon YJ	15015615	2004
32	CYP17 mutation E305G causes isolated 17,20-lyase deficiency by selectively altering substrate binding. ⁵³ ⁶²	Sherbet DP...Auchus RJ	14504283	2003
33	Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. ⁵³ ⁶²	Shozu M...Bulun SE	12736278	2003
34	Gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung. ⁵³ ⁶²	Yaturu S...Gill S	12917067	2003
35	Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. ⁵³ ⁶²	Keller R...Mongini F	12522680	2002
36	On the inhibitory action of 29 drugs having side effect gynecomastia on estrogen production. ⁵³ ⁶²	Satoh T...Yoshizawa I	12477487	2002
37	[An elderly case of advanced gastric cancer with gynecomastia and high serum levels of hCG]. ⁵³ ⁶²	Yamamoto J...Hashimoto T	12404754	2002
38	Gynecomastia with sulpiride. ⁵³ ⁶²	Kaneda Y...Fujii A	11846864	2002
39	Effects of risperidone on gonadal axis hormones in schizophrenia. ⁵³ ⁶²	Kaneda Y	11793612	2001
40	Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor? ⁵³ ⁶²	Venara M...Chemes H	11688457	2001
41	Measurement of androgen and estrogen receptors in breast tissue from subjects with anabolic steroid-dependent gynecomastia. ⁵³ ⁶²	Calzada L...Pedron N	11554608	2001
42	Occult Leydig cell tumor in a patient with gynecomastia. ⁵³ ⁶²	Anderson MS...Biller BM	11497478	2001
43	Pituitary prolactin-secreting macroadenoma combined with bilateral breast cancer in a 45-year-old male. ⁵³ ⁶²	Forloni F...Beck-Peccoz P	11434671	2001
44	Aromatase expression in the human male. ⁵³ ⁶²	Brodie A...Yue W	11403890	2001
45	Overexpression of aromatase in transgenic male mice results in the induction of gynecomastia and other biochemical changes in mammary glands. ⁵³ ⁶²	Gill K...Tekmal RR	11358670	2001
46	[De La Chapelle syndrome]. ⁵³ ⁶²	Dupuy O...Bauduceau B	11268892	2001
47	Estrogen and progesterone receptors in gynecomastia. ⁵³ ⁶²	Pensler JM...Molteni A	11039372	2000
48	Immunohistochemical localization of prostate-specific antigen in ductal epithelium of male breast. Potential diagnostic pitfall in patients with gynecomastia. ⁵³ ⁶²	Gatalica Z...Kovatich AJ	10937064	2000
49	Serum inhibin B concentration in a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome. ⁵³ ⁶²	Bergada I...Campo S	10689645	2000
50	Aromatase and gynecomastia. ⁵³ ⁶²	Braunstein GD	10731125	1999

Sources

Genes for Gynecomastia

Genes related to Gynecomastia (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	34.09	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	16392624 18426832 8768875 (more) 10731125 11358670 9589695 12477487 17543732 9365182 14963480 18622206 10689645 18462445 15579017 15510985 9543166 17584767 16452534 18417782 16238933 18700016 15947469 20088436 14982857 15483104 15579195 8024242 11403890 12736278
2	PRL	Prolactin	Protein Coding	24.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9586418 9334596 11434671 (more) 12522680 11793612 11497478 17655655 16633146 9177513 17638022 18978497 18816151 17925790 18613925 10071182 15141644 15277975 16865035 9934944 11846864 18004132
3	AR	Androgen Receptor	Protein Coding	24.21	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
4	HSD17B3	Hydroxysteroid 17-Beta Dehydrogenase 3	Protein Coding	22.58	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Summaries (show sections)
5	KLK3	Kallikrein Related Peptidase 3	Protein Coding	22.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10937064 16280763 15681525
6	ESR1	Estrogen Receptor 1	Protein Coding	20.1	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8706561 1874085 11554608 (more) 15238910 16355805
7	SRD5A1	Steroid 5 Alpha-Reductase 1	Protein Coding	19.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	2327864 1530365
8	SHBG	Sex Hormone Binding Globulin	Protein Coding	19.5	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18465688 15379424 2137877
9	PGR	Progesterone Receptor	Protein Coding	19.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11039372 8326458 2331807
10	CGB5	Chorionic Gonadotropin Subunit Beta 5	Protein Coding	15.22	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1413316 7621102 7783824 (more) 1894030 12404754
11	INHA	Inhibin Subunit Alpha	Protein Coding	14.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11688457
12	POMC	Proopiomelanocortin	Protein Coding	13.99	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
13	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	13.66	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12917067 9235082 1321306
14	SRY	Sex Determining Region Y	Protein Coding	13.57	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9030973 11268892
15	PHF6	PHD Finger Protein 6	Protein Coding	13.12	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
16	ESR2	Estrogen Receptor 2	Protein Coding	12.9	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
17	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	12.88	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
18	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	12.71	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	2142288
19	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	12.56	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
20	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	12.42	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18729003
21	SRD5A2	Steroid 5 Alpha-Reductase 2	Protein Coding	12.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9467575
22	DRD2	Dopamine Receptor D2	Protein Coding	12.16	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
23	LEP	Leptin	Protein Coding	12.15	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
24	GPER1	G Protein-Coupled Estrogen Receptor 1	Protein Coding	12.12	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
25	POR	Cytochrome P450 Oxidoreductase	Protein Coding	11.98	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)

Sources

Variations for Gynecomastia

ClinVar genetic disease variations for Gynecomastia:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	KIF4A	NM_012310.5(KIF4A):c.1553G>C (p.Arg518Pro)	SNV	Uncertain Significance	523498	rs766819113	GRCh37: X:69573536-69573536 GRCh38: X:70353686-70353686

Sources

Expression for Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Sources

Pathways for Gynecomastia

Pathways related to Gynecomastia according to GeneCards Suite gene sharing:

(show all 24)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	13.83	PRL POMC PGR NR3C2 KLK3 INHA
2	Signal Transduction ⁶⁶	13.64	AR CGA ERBB2 ESR1 ESR2 GNRH1
3	Metabolism of steroids ⁶⁶ Show member pathways Activation of gene expression by SREBF (SREBP) ⁶⁶ allopregnanolone biosynthesis ⁶¹ androgen biosynthesis ⁶¹ Cholesterol synthesis disorders ⁷⁴ Defective CYP17A1 causes AH5 ⁶⁶ Regulation of cholesterol biosynthesis by SREBP (SREBF) ⁶⁶ Sterol regulatory element-binding proteins (SREBP) signaling ⁷⁴ Vitamin D (calciferol) metabolism ⁶⁶	12.51	SRD5A1 POMC HSD17B3 CYP19A1 CGA
4	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.34	PGR ESR2 ESR1 ERBB2
5	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁷⁴ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶ thyroid hormone biosynthesis ⁶¹	12.09	POMC INHA CGB5 CGA
6	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12	SRD5A1 KLK3 ERBB2 AR
7	Signaling by ERBB4 ⁶⁶ Show member pathways Downregulation of ERBB4 signaling ⁶⁶ ErbB4 signaling events ⁶¹ Nuclear signaling by ERBB4 ⁶⁶	11.92	PRL PGR ESR1 ERBB2
8	Nuclear receptors ⁷⁴ Show member pathways Nuclear Receptor transcription pathway ⁶⁶ SUMOylation of intracellular receptors ⁶⁶	11.8	PGR NR3C2 ESR2 ESR1 AR
9	TGF-beta Signaling Pathways ⁶⁵	11.78	ESR2 ESR1 AR
10	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors ⁶⁶ Show member pathways Activation of the TFAP2 (AP-2) family of transcription factors ⁶⁶ Negative regulation of activity of TFAP2 (AP-2) family transcription factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of cell cycle factors ⁶⁶ TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ⁶⁶ TFAP2 (AP-2) family regulates transcription of other transcription factors ⁶⁶ TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation ⁶⁶	11.73	ESR1 ERBB2 CGB5 CGA
11	Glucocorticoid receptor regulatory network ⁶¹	11.65	PRL POMC CGA
12	Validated nuclear estrogen receptor alpha network ⁶¹	11.55	PRL PGR ESR2 ESR1
13	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Defective CYP11A1 causes AICSR ⁶⁶ Defective CYP11B1 causes AH4 ⁶⁶ Defective CYP21A2 causes AH3 ⁶⁶ Electron transport from NADPH to Ferredoxin ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid and Mineralcorticoid Metabolism ⁷⁴ Glucocorticoid biosynthesis ⁶⁶ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.54	SRD5A1 POMC HSD17B3 CYP19A1 CGA
14	Androstenedione and testosterone biosynthesis and metabolism p.1 ²² Show member pathways Estrogen biosynthesis ²² Estrone metabolism ²² Steroid biosynthesis ⁷⁴	11.49	CYP19A1 CYP3A4 HSD17B3
15	Regulation of Androgen receptor activity ⁶¹	11.44	SRY KLK3 AR
16	Oxysterols derived from cholesterol ⁷⁴ Show member pathways 7-oxo-C and 7-beta-HC pathways ⁷⁴	11.43	ESR2 ESR1 CYP3A4
17	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.32	AR CGA CYP19A1 CYP3A4
18	FOXA1 transcription factor network ⁶¹	11.25	KLK3 ESR1 AR
19	Ovarian infertility ⁷⁴	11.11	PGR INHA ESR2 CYP19A1
20	Nongenotropic Androgen signaling ⁶¹	10.89	SHBG GNRH1 AR
21	Hormone ligand-binding receptors ⁶⁶	10.69	GNRH1 CGA
22	Mammary gland development pathway - Puberty (Stage 2 of 4) ⁷⁴	10.69	PGR ESR1 ERBB2
23	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ⁷⁴	10.53	PRL PGR ESR2 ESR1 ERBB2
24	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.73	ESR2 ESR1 CYP19A1

Sources

GO Terms for Gynecomastia

Cellular components related to Gynecomastia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	pituitary gonadotropin complex	GO:0061696	8.8	CGB5 CGA

Biological processes related to Gynecomastia according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.28	PRL POMC PGR NR3C2 INHA GNRH1
2	male gonad development	GO:0008584	10.06	AR ESR1 INHA SRD5A1
3	cellular response to estradiol stimulus	GO:0071392	9.99	SRD5A1 ESR2 ESR1
4	cell-cell signaling	GO:0007267	9.97	AR CGB5 ESR2 GNRH1 INHA PGR
5	steroid biosynthetic process	GO:0006694	9.87	CYP19A1 CYP3A4 HSD17B3 SRD5A1
6	intracellular estrogen receptor signaling pathway	GO:0030520	9.85	ESR2 ESR1 AR
7	prostate gland growth	GO:0060736	9.84	CYP19A1 AR
8	female genitalia development	GO:0030540	9.83	SRD5A1 CYP19A1
9	testosterone biosynthetic process	GO:0061370	9.8	HSD17B3 CYP19A1
10	mammary gland development	GO:0030879	9.8	PRL PGR CYP19A1
11	androgen catabolic process	GO:0006710	9.78	SRD5A1 CYP19A1
12	tertiary branching involved in mammary gland duct morphogenesis	GO:0060748	9.73	PGR AR
13	androgen metabolic process	GO:0008209	9.43	SRD5A1 ESR1 CYP3A4 CYP19A1
14	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.32	PGR NR3C2 ESR2 ESR1 AR

Molecular functions related to Gynecomastia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	enzyme binding	GO:0019899	10.18	PHF6 PGR ESR2 ESR1 CYP3A4 AR
2	transcription coactivator binding	GO:0001223	9.95	PGR ESR1 AR
3	nuclear receptor activity	GO:0004879	9.85	PGR NR3C2 ESR2 ESR1 AR
4	lipid binding	GO:0008289	9.8	SHBG PGR NR3C2 ESR2 ESR1 AR
5	nuclear steroid receptor activity	GO:0003707	9.8	ESR1 ESR2 NR3C2 PGR
6	estrogen response element binding	GO:0034056	9.76	ESR2 ESR1
7	androgen binding	GO:0005497	9.73	SHBG AR
8	hormone activity	GO:0005179	9.7	PRL POMC INHA GNRH1 CGB5 CGA
9	nuclear estrogen receptor activity	GO:0030284	9.67	ESR2 ESR1
10	steroid binding	GO:0005496	9.47	SHBG PGR NR3C2 ESR2 ESR1 CYP3A4

Sources

Sources for Gynecomastia

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: GYN001 MIFTS: 47	Gynecomastia Categories: Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Drugs Expand all tables

Gynecomastia

Aliases & Classifications for Gynecomastia

MalaCards integrated aliases for Gynecomastia:

Classifications:

External Ids:

Summaries for Gynecomastia

Related Diseases for Gynecomastia

Diseases related to Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Gynecomastia:

Symptoms & Phenotypes for Gynecomastia

MGI Mouse Phenotypes related to Gynecomastia:

Drugs & Therapeutics for Gynecomastia

Drugs for Gynecomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Genetic Tests for Gynecomastia

Genetic tests related to Gynecomastia:

Anatomical Context for Gynecomastia

Organs/tissues related to Gynecomastia:

Publications for Gynecomastia

Articles related to Gynecomastia:

Genes for Gynecomastia

Genes related to Gynecomastia (0 elite genes):

Variations for Gynecomastia

ClinVar genetic disease variations for Gynecomastia:

Expression for Gynecomastia

Pathways for Gynecomastia

Pathways related to Gynecomastia according to GeneCards Suite gene sharing:

GO Terms for Gynecomastia

Cellular components related to Gynecomastia according to GeneCards Suite gene sharing:

Biological processes related to Gynecomastia according to GeneCards Suite gene sharing:

Molecular functions related to Gynecomastia according to GeneCards Suite gene sharing:

Sources for Gynecomastia

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :