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Haemophilus Influenzae

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Haemophilus Influenzae

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MalaCards integrated aliases for Haemophilus Influenzae:

Name: Haemophilus Influenzae 20
H. Influenzae 20

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 B96.3
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Summaries for Haemophilus Influenzae

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MalaCards based summary : Haemophilus Influenzae, also known as h. influenzae, is related to epiglottitis and bacterial meningitis. An important gene associated with Haemophilus Influenzae is LACTB (Lactamase Beta), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Proteoglycans in cancer. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and eye, and related phenotype is homeostasis/metabolism.

Wikipedia : 73 Haemophilus influenzae (formerly called Pfeiffer's bacillus or Bacillus influenzae) is a Gram-negative,... more...

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Related Diseases for Haemophilus Influenzae

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Diseases related to Haemophilus Influenzae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 574)
# Related Disease Score Top Affiliating Genes
1 epiglottitis 32.6 OMP LACTB
2 bacterial meningitis 31.7 TNF TLR2 LACTB CXCL8
3 pneumonia 31.6 TNF TLR2 LACTB CXCL8
4 meningitis 31.6 TNF TLR2 LACTB CXCL8
5 otitis media 31.6 TNF TLR2 LACTB CXCL8
6 septic arthritis 31.1 TNF TLR2 CXCL8
7 pericarditis 30.9 VTN TNF CXCL8
8 bacterial conjunctivitis 30.9 TNF CXCL8
9 osteomyelitis 30.9 TNF TLR2 CXCL8
10 neisseria meningitidis infection 30.9 TLR2 OMP LACTB
11 bronchitis 30.8 TNF TLR2 LTF LACTB CXCL8
12 bronchopneumonia 30.8 TNF CXCL8
13 bronchiectasis 30.8 TNF TLR2 CXCL8
14 pulmonary disease, chronic obstructive 30.8 TNF TLR2 CXCL8
15 lung abscess 30.7 TNF LACTB
16 bacterial infectious disease 30.6 TNF TLR2 LTF CXCL8
17 peritonitis 30.6 TNF TLR2 CXCL8
18 toxic shock syndrome 30.6 TNF TLR2 CXCL8
19 endophthalmitis 30.6 TNF TLR2 CXCL8
20 endocarditis 30.5 TNF TLR2 LACTB CXCL8
21 salpingitis 30.5 TNF TLR2
22 urethritis 30.5 TNF TLR2 CXCL8
23 pharyngitis 30.5 TNF LACTB CXCL8
24 tonsillitis 30.4 TNF TLR2 LACTB CXCL8
25 meningococcal meningitis 30.4 TLR2 CFH
26 bacterial pneumonia 30.3 TNF TLR2 LACTB CXCL8
27 disease by infectious agent 30.3 TNF TLR2 LACTB
28 tracheitis 30.3 TNF CXCL8
29 vaginal discharge 30.3 TNF CXCL8
30 vaginitis 30.2 TNF TLR2 CXCL8
31 gastroenteritis 30.2 TNF LACTB CXCL8
32 aseptic meningitis 30.2 TNF LTF CXCL8
33 keratitis, hereditary 30.2 TNF TLR2 CXCL8
34 chlamydia 30.2 TNF TLR2 CXCL8
35 streptococcus pneumonia 30.2 TNF TLR2 CXCL8
36 middle ear disease 30.1 TNF TLR2 CXCL8
37 cystic fibrosis 30.1 TNF TLR2 LTF LACTB CXCL8
38 bacterial sepsis 30.1 TNF TLR2 CXCL8
39 cervicitis 30.1 TNF CXCL8
40 aspiration pneumonitis 30.1 TNF CXCL8
41 bronchiolitis 30.0 TNF TLR2 CXCL8
42 endometritis 30.0 TNF TLR2 LACTB CXCL8
43 adult respiratory distress syndrome 29.9 TNF TF CXCL8
44 preterm premature rupture of the membranes 29.9 TNF TLR2 CXCL8
45 allergic disease 29.8 TNF TLR2 CXCL8
46 chronic mucocutaneous candidiasis 29.7 TNF TLR2 CLEC7A
47 periodontitis 29.7 TNF TLR2 CXCL8
48 chlamydia pneumonia 29.7 TNF TLR2 CXCL8
49 aphthous stomatitis 29.7 TNF TLR2 CXCL8
50 asthma 29.7 VTN TNF TLR2 TF CXCL8

Graphical network of the top 20 diseases related to Haemophilus Influenzae:



Diseases related to Haemophilus Influenzae
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Symptoms & Phenotypes for Haemophilus Influenzae

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MGI Mouse Phenotypes related to Haemophilus Influenzae:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CFH CLEC7A LACTB LTF OMP TF
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Drugs & Therapeutics for Haemophilus Influenzae

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Drugs for Haemophilus Influenzae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 4
2 Antibodies Phase 4
3 Vaccines Phase 4
4
Iron Approved Phase 3 7439-89-6 23925 29936
5
Edetic Acid Approved, Vet_approved Phase 3 60-00-4, 62-33-9 6049
6
Pentetic acid Approved Phase 3 67-43-6
7
Lactitol Approved, Investigational Phase 3 585-86-4 157355
8 PENTA Phase 3
9 Immunoglobulins, Intravenous Phase 3
10 Fibrinolytic Agents Phase 3
11 Anticoagulants Phase 3
12 polysaccharide-K Phase 3
13 Antidotes Phase 3
14 Chelating Agents Phase 3
15 Protective Agents Phase 3
16 Iron Chelating Agents Phase 3
17 Calcium, Dietary Phase 3
18 Immunoglobulin E Phase 3
19 Hemagglutinins Phase 3
20 Somatomedin B Phase 3
21 taxane Phase 3
22 Antitoxins Phase 3
23 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
24 Adjuvants, Immunologic Phase 3
25 Broncho-Vaxom Phase 3
26 Immunologic Factors Phase 3
27
Calcium Nutraceutical Phase 3 7440-70-2 271
28
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
29
Streptomycin Approved, Vet_approved Phase 1, Phase 2 57-92-1 19649
30
Aluminum sulfate Approved Phase 1, Phase 2 10043-01-3
31 Pharmaceutical Solutions Phase 2
32 Antibiotics, Antitubercular Phase 1, Phase 2
33 Anti-Bacterial Agents Phase 1, Phase 2
34 Aluminum phosphate Phase 1, Phase 2
35
tannic acid Approved 1401-55-4
36
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
37
BCG vaccine Approved, Investigational
38
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
39 Anti-Retroviral Agents
40 Rho(D) Immune Globulin
41 gamma-Globulins
42 Retinol palmitate
43 retinol
44 Vitamins
45
Serine Investigational, Nutraceutical 56-45-1 5951

Interventional clinical trials:

(show top 50) (show all 90)
# Name Status NCT ID Phase Drugs
1 Immunogenicity and Safety Study of GSK Biologicals' Combined Diphtheria-tetanus-acellular Pertussis-hepatitis B-inactivated Polio-virus and Haemophilus Influenzae Type b Vaccine (Infanrix Hexaâ„¢) (217744) in Healthy Infants Born to Mothers Vaccinated With Boostrixâ„¢ During Pregnancy or Immediately Post-delivery Completed NCT02422264 Phase 4 Prevnar13
2 A Demonstration Project for the Elimination of Haemophilus Influenzae Type B in Three Rural Alaska Native Villages Completed NCT00153556 Phase 4
3 Phase 4 Study of Haemophilus Influenzae Type b Vaccine in Different Injection Site Completed NCT01761136 Phase 4
4 A Post Marketing Surveillance Study to Monitor the Reactogenicity and Safety of Vaxemâ„¢Hib When Administered According to the Prescribing Information in Korea Completed NCT01404962 Phase 4
5 Assess the Safety & Reactogenicity of GSK Biologicals Hib Vaccine Co-administered With Chinese Local DTPw Vaccine When Compared to Chinese Local DTPw Vaccine Administered Alone, in Healthy Infants at 3,4 & 5 Mths of Age Completed NCT00158795 Phase 4
6 Assessment of Long-term Antibody Persistence After a Booster Dose of GSK Biologicals' Hib & Meningococcal C Vaccine (Menitorixâ„¢) 811936 Given at 12-15 Months of Age to Subjects Primed With 3 Doses of Menitorixâ„¢ at 2, 3, 4 Months of Age Completed NCT00454987 Phase 4
7 The Immediate and Longterm Immune Responses of UK Infants and Young Children to a Booster Dose of Hib Vaccine Completed NCT00197782 Phase 4
8 A Prospective, Open-label, Interventional Phase IV Study to Assess the Safety of EupentaTM Inj. {Fully Liquid Pentavalent Vaccine, Adsorbed Diphtheria-Tetanus-whole-cell Pertussis-Hepatitis B (rDNA [Recombinant-deoxyribonucleic Acid])-Haemophilus Influenzae Type b Conjugate Vaccine} Not yet recruiting NCT04056728 Phase 4
9 A Phase IV, Non-Inferiority, Observer Blind, Randomized Clinical Study Comparing Safety And Immunogenicity Of DTP-HB-Hib Vaccination by Disposable-Syringe Jet Injector To Vaccination By Needle And Syringe In Healthy Infants In India Terminated NCT02409095 Phase 4
10 A Phase III, Double Blind, Parallel-controlled, Randomised Study to Evaluate the Safety and Immunogenicity of Haemophilus Influenzae Type b Conjugate Vaccine in Healthy Children 2 Months to 5 Years of Age Unknown status NCT02560272 Phase 3
11 A Study of Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines to Inform Policy Regarding Pneumococcal Vaccination of Papua New Guinean Children Unknown status NCT01619462 Phase 3
12 Immune Memory of GSK's DTPw-HBV/Hib Vaccine by Giving Plain PRP Polysaccharide at 10 Mths. Immuno & Reacto of a Booster Dose of DTPw-HBV/Hib or DTPw-HBV or DTPw-HBV+Hib at 15-18 Mths in Infants Previously Primed With DTPw-HBV/Hib Completed NCT00169442 Phase 3
13 A Phase IIIb, Controlled, Open Label, Single-Center, Persistency, Extension Study in Chinese Children After a 2+1 Dose Series of Either CRM197-Conjugate Haemophilus Influenzae Type b Vaccine or Tetanus Toxoid-Conjugate Haemophilus Influenzae Type b Vaccine Completed NCT02139228 Phase 3
14 A Phase III, Observer-blind, Randomized, Controlled, Multicenter Study to Investigate Immunogenicity and Safety of Haemophilus Influenzae Type b Vaccine in 2 - 4 Months Old Healthy Infants in China, According to the Recommended Regimen of 3 Intramuscular Doses Given One Month Apart Completed NCT00808392 Phase 3
15 A Phase III Open Label, Multi-Center Pediatric Study in China Comparing Booster Doses of Vaxem Hib and Hiberix Vaccines for the Prevention of Haemophilus Influenzae Type b (Hib) Infection Completed NCT01025544 Phase 3
16 A Phase 3 Open-label Study to Evaluate the Immunogenicity and Safety of a Mixed (HEXA/PENTA/HEXA) Primary Series Schedule That Includes V419 (PR5I) at 2 and 6 Months of Age and Pediacel at 4 Months of Age. Completed NCT01839188 Phase 3
17 Assess Reactogenicity & Safety of a Booster of Either Tritanrix-HepB/Hib-MenAC or Tritanrix-HepB/Hiberix Given (Single-blind) at 15-18 (Philippines)/15-24 Mths (Thailand) & a Dose of Mencevax ACWY at 24-30 Mths (Open Label) Completed NCT00228917 Phase 3
18 Assess Immunogenicity, Safety & Reactogenicity of a 4th Dose of GSK Biologicals' Tritanrix-HepB/Hib-MenAC at 15-24 m & of a Dose of Mencevax ACWY at 24-30 m in Subjects Primed With 3 Doses of Tritanrix-HepB/Hib-MenAC Completed NCT00136604 Phase 3
19 A Phase III Randomized, Double-Blind, Active-Comparator Controlled Clinical Trial to Study the Safety, Tolerability, and Immunogenicity of V419 in Healthy Infants When Given at 2, 4, and 11 to 12 Months Completed NCT01480258 Phase 3
20 Immunogenicity and Safety of GSK Biologicals' Combined Diphtheria-tetanus-acellular Pertussis-inactivated Poliovirus and Haemophilus Influenzae Type b (DTPa-IPV/Hib) Conjugate Vaccine Completed NCT02858440 Phase 3
21 A Phase III Open-label Randomised Study, to Evaluate the Immunogenicity and Safety of the Concomitant Administration of V419 (PR5I) Given at 2, 3 and 4 Months of Age With Two Types of Meningococcal Serogroup C Conjugate (MCC) Vaccines Given at 3 and 4 Months of Age, and Followed by the Administration at 12 Months of Age of a Combined Haemophilus Influenzae Type b-MCC Vaccine Completed NCT01553279 Phase 3
22 A Multicentre, Comparative, Two-arm, Parallel-group, Double-blind, Randomized Phase III Study to Assess Immunogenicity and Safety of LBVH0101 (Haemophilus Influenzae Type b Tetanus Toxoid Conjugate Vaccine) Compared With Hiberixâ„¢ Vaccine in Healthy Infants at Two, Four and Six Months of Age Completed NCT01019772 Phase 3
23 A Randomized, Positive-controlled, Non-inferiority Phase III Clinical Trial of a Haemophilus Influenzae Type b (Hib) Conjugate Vaccine in Healthy Infants and Children Completed NCT02692859 Phase 3
24 A Single-blind, Randomized, Controlled, Multinational Study for the Evaluation of Safety of GlaxoSmithKline (GSK) Biologicals' Investigational Vaccination Regimen Compared to Monovalent Haemophilus Influenzae Type b (Hib) Control Vaccine in Healthy Infants at 2, 4, 6, and 12 to 15 Months of Age. Completed NCT00345579 Phase 3
25 Immunogenicity and Safety of PEDIACEL®, a Combined Diphtheria, Tetanus, Five Component Acellular Pertussis, Inactivated Poliomyelitis and Haemophilus Influenzae Type b Conjugate Vaccine (Adsorbed), Compared to Infanrix®-IPV+Hib When Both Vaccines Are Co-Administered With Prevenar® to Infants and Toddlers at 2, 3, 4 and 12-18 Months of Age Completed NCT00343421 Phase 3
26 A Phase III, Randomized, Multinational Study, Double-blinded for the Immunogenicity and Consistency Evaluation of 3 Hib-MenCY-TT Vaccine Lots and Single-blinded and Controlled for the Evaluation of Safety and Immunogenicity of GSK Biologicals' Haemophilus Influenzae Type b and Neisseria Meningitidis Serogroups C and Y-tetanus Toxoid Conjugate Vaccine Combined (Hib-MenCY-TT) Compared to Monovalent Hib Vaccine in Healthy Infants at 2, 4, 6, and 12 to 15 Months of Age. Completed NCT00289783 Phase 3
27 A Randomised, Controlled, Double-Blind Study of the Immunogenicity and Safety of PEDIACEL®, a Combined Diphtheria, Tetanus, Five Component Acellular Pertussis, Inactivated Poliomyelitis and Haemophilus Influenzae Type b Conjugate Vaccine (Adsorbed) Compared To Infanrix®-IPV+Hib When Both Vaccines Are Given to Infants Using a Three Dose Immunisation Schedule ("Nordic Schedule" 3-5-12 Months) Completed NCT00287092 Phase 3
28 A Study in Healthy Infants of the Safety, Tolerability, and Immunogenicity of Haemophilus Influenzae, Type b/Hepatitis B Vaccine Manufactured With a Modified Process Completed NCT00441012 Phase 3
29 Safety and Immunogenicity of Booster Vaccination With PEDIACEL®, a Combined Diphtheria, Tetanus, Five Component Acellular Pertussis, Inactivated Poliomyelitis and Haemophilus Influenzae Type b Conjugate Vaccine (Adsorbed), Compared to Booster Vaccination With Infanrix® Hexa When Both Vaccines Are Co-Administered With Prevenar® to Toddlers 11-18 Months of Age Completed NCT00355654 Phase 3
30 Phase III, Partially Double-blind Study to Evaluate Consistency and Immunogenicity of 3 Lots of GSK Biologicals' Hib Conjugate Vaccine 208108 Versus ActHIB and Pentacel at 2, 4, 6 and 15-18 Months of Age in Healthy Infants Completed NCT01000974 Phase 3
31 A Phase III Study to Assess Immunogenicity and Safety of 4th LBVH0101 Vaccination Compared With 4th Hiberixâ„¢ Vaccination in Healthy Toddlers Who Completed Primary Vaccination in LG-VHCL002 Study Completed NCT01251133 Phase 3
32 A Phase III Observer Blind Single-Coordinating Center Pediatric Study in China Comparing a Booster Dose of Vaxemâ„¢ Hib to HIBERIX® When Given as Part of a Local Dosing Regimen in Infants Completed NCT01226953 Phase 3
33 A Phase III Observer-Blind, Randomized, Controlled, Single-Coordinating Center Pediatric Study in China Comparing Two Doses of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Vaccine Versus a Tetanus Toxoid-Conjugated Vaccine Using a Local Dosing Regimen in Infants Completed NCT01044316 Phase 3
34 Immunogenicity & Safety Study in Preterm & Full-term Infants of GSK Biologicals' Hib-MenC Vaccine, Menitorixâ„¢ Co-administered With Infanrixâ„¢ Penta & Prevenarâ„¢ at 2, 4, 6 Months & as a Booster With Infanrixâ„¢ IPV & Prevenarâ„¢ at 16-18 Months Completed NCT00586612 Phase 3
35 A Phase III Observer-blind, Randomized, Controlled, Single-coordinating Center Study to Investigate Immunogenicity and Safety of a Monovalent Glycoprotein-conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 13-59 Months Old Healthy Children in China, According to the Recommended Regimen of 1 Dose Completed NCT01125527 Phase 3
36 Safety and Reactogenicity of GSK Biologicals' DTPa-IPV/Hib (Infanrixâ„¢-IPV/Hib) in Infants Completed NCT00964028 Phase 3
37 Study to Show Non-inferiority of Tritanrixâ„¢-HepB/Hib-MenAC (+/- Hepatitis B Vaccine at Birth) Versus Tritanrixâ„¢-HepB/Hiberixâ„¢ Without Hepatitis B Vacc. at Birth for Antibody Response to All Vaccine Antigens Given in Healthy Infants Completed NCT00290303 Phase 3
38 Study to Evaluate the Safety, Reactogenicity & Immunogenicity of a Booster Dose of GSK Biologicals' Hib-MenC Given With Priorixâ„¢, vs Hib-MenC or Priorixâ„¢ Only, in Toddlers (13-14 m) Primed With 3 Doses of Hib (as Part of a DTPa -Containing Vaccine) & MenC-CRM197 Conjugate Vaccines. Completed NCT00263653 Phase 3
39 Single-blind, Randomized, Controlled, Multinational Study for the Evaluation of Safety of GSK Biologicals' Hib-MenCY-TT Vaccine Compared to Monovalent Hib Control Vaccine in Healthy Infants at 2, 4, 6, and 12 to 15 Months of Age. Completed NCT00345683 Phase 3
40 Assess Safety & Reactogenicity of DTPa-IPV/Hib Vaccine Admnd at 3 & 4 Mths & DTPa-HBV-IPV/Hib Vaccine Admnd at 5 Mths, Followed by DTPa-IPV/Hib Vaccine at 18 Mths in Infants Who Received hepatitisB Vaccine at Birth & at One Month of Age Completed NCT00325143 Phase 3
41 Phase III, Open, Multicenter Study to Assess the Long-Term Persistence of a Booster Dose of GSK Biologicals' Hib-MenC Compared to a Booster Dose of Infanrixâ„¢ Hexa When Given to 14 Month-old Subjects Primed in Study DTPa-HBV-IPV-097 & Boosted in Study Hib-MenC-TT-010 BST: DTPa-HBV-IPV-097 Completed NCT00322335 Phase 3
42 Study to Demonstrate Non-inferiority of GSK Biologicals' Hib-MenC With Priorixâ„¢, Versus MenC-CRM197 Vaccine With Hiberixâ„¢ & Priorixâ„¢ in Toddlers Primed With Hib But Not MenC & to Evaluate Persistence up to 5 Years After Vaccination. Completed NCT00326118 Phase 3
43 Demonstrate Non-inferiority of GSK Biologicals' Tritanrixâ„¢-HepB/Hib-MenAC vs Tritanrixâ„¢-HepB/Hiberixâ„¢ With Respect to Anti-HBs Immune Response, When Given to Healthy Infants at 6,10 & 14 Weeks Age, After a Birth Dose of Hepatitis B Vaccine Completed NCT00317122 Phase 3
44 Demonstrate Non-inferiority of Men-C Immune Response of Hib-MenC With Infanrixâ„¢-IPV Versus a Licensed Men-C Vaccine With Pediacelâ„¢ When Given at 2, 3, 4 Months and the Immunogenicity of Hib-MenC When Given as a Booster Dose at 12-15 Months Completed NCT00258700 Phase 3
45 The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children Completed NCT04270552 Phase 3 Ismigen;Placebo
46 A Phase 3, Open-Label, Randomized, Multi-Center Study to Evaluate the Safety and Immunogenicity After One or Two Doses of Novartis Meningococcal ACWY Conjugate Vaccine Administered to Healthy Infants and Toddlers Completed NCT00667602 Phase 3
47 The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis Completed NCT04637425 Phase 3 Ismigen;Placebo
48 An Open, Randomised, Comparative, Multicentre Study of the Immunogenicity and Safety of Concomitant Versus Separate Administration of a Combined Measles, Mumps, Rubella and Varicella Live Vaccine (ProQuad®) and a Booster Dose of Infanrix® Hexa in Healthy Children 12 to 23 Months of Age Completed NCT00432042 Phase 3
49 A Phase 3, Randomized, Double-Blind Study of the Safety, Tolerability, Lot-to-Lot Consistency, Immunogenicity & Non-Interference With Concomitant Vaccinations of Serum Institute of PNEUMOSIL in Healthy Infants in The Gambia Completed NCT03197376 Phase 3
50 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Other Pediatric Vaccines in Healthy Toddlers Completed NCT03205371 Phase 3

Search NIH Clinical Center for Haemophilus Influenzae

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Genetic Tests for Haemophilus Influenzae

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Anatomical Context for Haemophilus Influenzae

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MalaCards organs/tissues related to Haemophilus Influenzae:

40
Neutrophil, Lung, Eye, Bone Marrow, Skin, Endothelial, B Cells
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Publications for Haemophilus Influenzae

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Articles related to Haemophilus Influenzae:

(show top 50) (show all 18874)
# Title Authors PMID Year
1
Acute otitis media and pneumococcal vaccination - an observational cross-sectional study of otitis media among vaccinated and unvaccinated children in Greenland. 61
33407056 2021
2
Management of sickle cell disease: current practices and challenges in a northeastern region of the Democratic Republic of the Congo. 61
33594960 2021
3
Encephalitis and meningitis in Western Africa: a scoping review of pathogens. 61
33340211 2021
4
Polarized cytokine release from airway epithelium differentially influences macrophage phenotype. 61
33588245 2021
5
Genome-wide analysis of urogenital and respiratory multidrug-resistant Haemophilus parainfluenzae. 61
33792695 2021
6
Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach. 61
33794090 2021
7
Draft genome sequence of a nontypeable Haemophilus influenzae strain used in the study of human respiratory infection. 61
33794985 2021
8
Interchangeability, immunogenicity and safety of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (Synflorix) and 13-valent-PCV (Prevenar13) schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial. 61
33681756 2021
9
Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD. 61
33759577 2021
10
AT-RvD1 Mitigates Secondhand Smoke-Exacerbated Pulmonary Inflammation and Restores Secondhand Smoke-Suppressed Antibacterial Immunity. 61
33558371 2021
11
Epidemiology, Etiology and Clinical Aspects of Childhood Acute Encephalitis in a Tertiary Pediatric Hospital in Costa Rica. 61
33060517 2021
12
In vitro antimicrobial activity of daptomycin alone and in adjunction to either amoxicillin, cefotaxime or rifampin against the main pathogens responsible for bacterial meningitis in adults. 61
33774218 2021
13
Molecular diagnostic assays for the detection of common bacterial meningitis pathogens: A narrative review. 61
33721818 2021
14
Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD. 61
33766947 2021
15
Outcomes of protracted bacterial bronchitis in children: A 5-year prospective cohort study. 61
33045125 2021
16
Mother and son cases of Bickerstaff's brainstem encephalitis and fisher syndrome with serum anti-GQ1b IgG antibodies: a case report. 61
33743625 2021
17
Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD). 61
33455514 2021
18
Association between nasal and nasopharyngeal bacterial colonisation in early life and eczema phenotypes. 61
33759242 2021
19
Haemophilus influenzae and SARS-CoV-2: Is there a role for investigation? 61
33781659 2021
20
Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade. 61
33774804 2021
21
Evaluation of a Multiplex PCR Panel for the Microbiological Diagnosis of Pneumonia in Hospitalized Patients: Experience from an Academic Medical Center. 61
33434669 2021
22
Treatment of Community-Acquired Pneumonia: A Focus on Lefamulin. 61
33528794 2021
23
Nasopharyngeal carriage of otitis media pathogens in infants receiving 10-valent non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10), 13-valent pneumococcal conjugate vaccine (PCV13) or a mixed primary schedule of both vaccines: A randomised controlled trial. 61
33766422 2021
24
Humanized Anti-DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media. 61
33666254 2021
25
The Formation of Biofilm and Bacteriology in Otitis Media with Effusion in Children: A Prospective Cross-Sectional Study. 61
33808050 2021
26
Otitis media outcomes of a combined 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine and 13-valent pneumococcal conjugate vaccine schedule at 1-2-4-6 months: PREVIX_COMBO, a 3-arm randomised controlled trial. 61
33685411 2021
27
Pasteurella multocida acute epiglottitis. 61
32600824 2021
28
Impact of maternal diphtheria-tetanus-acellular pertussis vaccination on pertussis booster immune responses in toddlers: Follow-up of a randomized trial. 61
33612341 2021
29
Concomitant administration of a liquid formulation of human rotavirus vaccine (porcine circovirus-free) with routine childhood vaccines in infants in the United States: Results from a phase 3, randomized trial. 61
33077301 2021
30
Protective immune responses against Haemophilus influenza type b elicited by a fully-liquid DTaP-IPV-Hib-HepB vaccine (VAXELISâ„¢). 61
33541794 2021
31
Community-acquired Haemophilus influenzae meningitis in adults. 61
33774020 2021
32
Detection of Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae in Culture Negative Cerebrospinal Fluid Samples from Meningitis Patients Using a Multiplex Polymerase Chain Reaction in Nepal. 61
33804301 2021
33
Emergence of Haemophilus influenzae with low susceptibility to quinolones isolated from pediatric patients in Japan. 61
33658143 2021
34
Cefotaxime resistance in invasive Haemophilus influenzae isolates in Germany 2016-19: prevalence, epidemiology and relevance of PBP3 substitutions. 61
33501993 2021
35
Sialic acid protects nontypeable Haemophilus influenzae from natural IgM and promotes survival in murine respiratory tract. 61
33782153 2021
36
Haemophilus influenzae causes cellular trans-differentiation in human bronchial epithelia. 61
33646896 2021
37
In vitro activity of ceftaroline against bacterial pathogens isolated from patients with skin and soft tissue and respiratory tract infections in the Middle East and Africa: AWARE global surveillance programme 2015-2018. 61
33373731 2021
38
The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea. 61
33758087 2021
39
The Burden of Invasive Vaccine-Preventable Diseases in Adults in the Middle East and North Africa (MENA) Region. 61
33751422 2021
40
Glyconanoparticles as tools to prevent antimicrobial resistance. 61
33728545 2021
41
Sputum susceptibilities in a nationwide veteran cohort. 61
33662473 2021
42
Colloidal silver combating pathogenic Pseudomonas aeruginosa and MRSA in chronic rhinosinusitis. 61
33690064 2021
43
Infant Vaccinations among Mothers with Substance-Use Disorders: A Comparative Study. 61
33060111 2021
44
Otopathogen interactions in the nasopharynx of children, and the predictive value of nasopharyngeal aspirate culture for the aetiology of upper respiratory infections. 61
33655670 2021
45
National database study of trends in bacteraemia aetiology among children and adults in Japan: a longitudinal observational study. 61
33785491 2021
46
In-laboratory quality control of nutrients for automatic bacteriology analyzer YUNON®Labstar 50. 61
33734645 2021
47
Bacterial Meningitis in Children: Neurological Complications, Associated Risk Factors, and Prevention. 61
33807653 2021
48
[Expert consensus on informed consent for vaccination (part two)]. 61
33706426 2021
49
[Expert consensus on informed consent for vaccination (part two)]. 61
33706469 2021
50
A systematic literature review of economic evaluations of pneumococcal conjugate vaccines in east and southeast Asia (2006-2019). 61
33682584 2021
Sources

Variations for Haemophilus Influenzae

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Expression for Haemophilus Influenzae

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Search GEO for disease gene expression data for Haemophilus Influenzae.
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Pathways for Haemophilus Influenzae

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Pathways related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
IL-17 Family Signaling Pathways 64
Show member pathways
 12.05 TNF TLR2 CXCL8
2
Proteoglycans in cancer 36
12.01 VTN TNF TLR2
3
Diseases associated with the TLR signaling cascade 65
Show member pathways
 11.97 TNF TLR2 CXCL8
4
Tuberculosis 36
11.91 TNF TLR2 CLEC7A
5
IL-1 Family Signaling Pathways 64
Show member pathways
 11.88 TNF TLR2 CXCL8
6
Bacterial infections in CF airways 23
Show member pathways
 11.83 TNF TLR2 CXCL8
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.79 TNF TF CXCL8
8
Amoebiasis 36
11.51 TNF TLR2 CXCL8
9
Rheumatoid arthritis 36
11.4 TNF TLR2 CXCL8
10
Phagocytosis of Microbes 63
11.26 VTN TLR2 CLEC7A
11
Legionellosis 36
10.89 TNF TLR2 CXCL8
12
EBV LMP1 signaling 1
10.87 TNF CXCL8
13
Overview of nanoparticle effects 1
10.65 TNF CXCL8
14
Malaria 36
10.5 TNF TLR2 CXCL8
Sources

GO Terms for Haemophilus Influenzae

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Cellular components related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 VTN TNF TF LTF CXCL8 CFH
2 blood microparticle GO:0072562 9.33 VTN TF CFH
3 recycling endosome GO:0055037 9.13 TNF TF LTF
4 cell surface GO:0009986 9.02 TNF TLR2 TF LTF CLEC7A

Biological processes related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.71 TNF TLR2 CXCL8 CLEC7A
2 immune response GO:0006955 9.67 VTN TNF TLR2 CXCL8
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.61 TNF TLR2 LTF
4 inflammatory response GO:0006954 9.56 TNF TLR2 CXCL8 CLEC7A
5 lipopolysaccharide-mediated signaling pathway GO:0031663 9.55 TNF TLR2
6 osteoclast differentiation GO:0030316 9.54 TNF TF
7 microglial cell activation GO:0001774 9.52 TNF TLR2
8 positive regulation of wound healing GO:0090303 9.51 VTN CLEC7A
9 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.49 TNF CLEC7A
10 positive regulation of receptor-mediated endocytosis GO:0048260 9.48 VTN TF
11 iron ion transport GO:0006826 9.46 TF LTF
12 embryonic digestive tract development GO:0048566 9.32 TNF CXCL8
13 response to molecule of bacterial origin GO:0002237 9.16 TLR2 CXCL8
14 positive regulation of interleukin-6 production GO:0032755 9.13 TNF TLR2 CLEC7A
15 positive regulation of interleukin-8 production GO:0032757 8.8 TNF TLR2 CLEC7A

Molecular functions related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 TLR2 LTF
2 heparin binding GO:0008201 9.13 VTN LTF CFH
3 pattern recognition receptor activity GO:0038187 8.62 TLR2 CLEC7A
Sources

Sources for Haemophilus Influenzae

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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