MCID: HMP009
MIFTS: 50

Haemophilus Influenzae

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Haemophilus Influenzae

Summaries for Haemophilus Influenzae

MalaCards based summary : Haemophilus Influenzae, also known as h. influenzae, is related to otitis media and pulmonary disease, chronic obstructive. An important gene associated with Haemophilus Influenzae is OMP (Olfactory Marker Protein), and among its related pathways/superpathways are Innate Immune System and Influenza A. The drugs Strawberry and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Haemophilus influenzae (formerly called Pfeiffer''s bacillus or Bacillus influenzae) is a Gram-negative,... more...

Related Diseases for Haemophilus Influenzae

Diseases related to Haemophilus Influenzae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 otitis media 30.9 CXCL8 IL1B TLR2 TNF
2 pulmonary disease, chronic obstructive 30.9 CXCL8 TLR2 TNF
3 meningitis 30.8 CXCL8 IL1B OMP TLR2 TNF
4 septic arthritis 30.7 CXCL8 TLR2
5 pneumonia 30.7 CXCL8 IL1B TLR2 TNF
6 arthritis 30.6 CXCL8 IL1B TNF
7 tonsillitis 30.4 CXCL8 IL1B TNF
8 bacterial meningitis 30.3 CXCL8 IL1B TLR2 TNF
9 endocarditis 30.2 CXCL8 TLR2 TNF
10 chorioamnionitis 30.2 CXCL8 IL1B TNF
11 lung disease 30.2 CXCL8 IL1B TLR2 TNF
12 laryngitis 30.1 IL1B TNF
13 pyelonephritis 30.0 CXCL8 IL1B TNF
14 peritonitis 30.0 CXCL8 IL1B TLR2 TNF
15 viral infectious disease 30.0 CXCL8 IL1B TNF
16 glossitis 30.0 IL1B TNF
17 pharyngitis 29.9 CXCL8 IL1B
18 endometritis 29.9 IL1B TNF
19 prostatitis 29.8 CXCL8 IL1B TNF
20 duodenal ulcer 29.8 CXCL8 IL1B TNF
21 lymphadenitis 29.8 CXCL8 IL1B TNF
22 osteomyelitis 29.8 CXCL8 IL1B TNF
23 cytomegalovirus infection 29.8 CXCL8 IL1B TNF
24 aseptic meningitis 29.5 CXCL8 IL1B LTF TNF
25 systemic lupus erythematosus 29.1 CFH CXCL8 IL1B TLR2 TNF
26 haemophilus meningitis 11.8
27 epiglottitis 11.7
28 complement component 3 deficiency, autosomal recessive 11.3
29 specific antibody deficiency 11.3
30 bronchitis 11.0
31 tetanus 10.9
32 diphtheria 10.8
33 pertussis 10.8
34 bacterial pneumonia 10.8
35 hepatitis 10.7
36 hepatitis b 10.7
37 influenza 10.5
38 poliomyelitis 10.4
39 cellulitis 10.4
40 cystic fibrosis 10.4
41 mumps 10.4
42 measles 10.4
43 rubella 10.4
44 fasciitis 10.3
45 necrotizing fasciitis 10.3
46 orbital cellulitis 10.2
47 hepatitis a 10.2
48 waterhouse-friderichsen syndrome 10.2
49 tungiasis 10.2 CXCL8 TNF
50 streptococcal toxic-shock syndrome 10.2 CXCL8 TNF

Graphical network of the top 20 diseases related to Haemophilus Influenzae:



Diseases related to Haemophilus Influenzae

Symptoms & Phenotypes for Haemophilus Influenzae

MGI Mouse Phenotypes related to Haemophilus Influenzae:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CFH CLEC7A IL1B LTF TF TLR2
2 homeostasis/metabolism MP:0005376 9.28 CFH CLEC7A IL1B LTF OMP TF

Drugs & Therapeutics for Haemophilus Influenzae

Drugs for Haemophilus Influenzae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 193)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Strawberry Approved Phase 4,Phase 3
2
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 26787-78-0 33613
3
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
4
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
5
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7 Estradiol valerate Approved, Investigational, Vet_approved Phase 4 979-32-8
8
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
9
Edetic Acid Approved, Vet_approved Phase 4,Phase 3,Phase 2 62-33-9, 60-00-4 6049
10
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
11
Pentetic acid Approved Phase 4,Phase 3,Phase 2 67-43-6
12
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
13
Ibuprofen Approved Phase 4,Phase 2 15687-27-1 3672
14
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
15
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 447043
16
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
17 Olodaterol Approved Phase 4 868049-49-4
18 Chlorine dioxide Investigational Phase 4 10049-04-4
19
BCG vaccine Investigational Phase 4,Not Applicable
20 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
21 Clavulanic Acids Phase 4,Phase 3,Phase 2,Not Applicable
22 Anti-Bacterial Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
23 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
24 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2,Not Applicable
25 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
26 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Not Applicable
31 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
32 Fluoroquinolones Phase 4,Phase 3,Not Applicable
33 MF59 oil emulsion Phase 4
34 Contraceptives, Oral, Combined Phase 4
35 Contraceptive Agents Phase 4
36 Estradiol 17 beta-cypionate Phase 4
37 Contraceptives, Oral Phase 4
38 Norgestimate, ethinyl estradiol drug combination Phase 4
39 Estradiol 3-benzoate Phase 4
40 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Ophthalmic Solutions Phase 4
42 Anticoagulants Phase 4,Phase 3,Phase 2
43 Calcium, Dietary Phase 4,Phase 3,Phase 2
44 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Iron Chelating Agents Phase 4,Phase 3,Phase 2
46 Chelating Agents Phase 4,Phase 3,Phase 2
47 Antidotes Phase 4,Phase 3,Phase 2
48 Disinfectants Phase 4
49 Chlorhexidine gluconate Phase 4
50 Anti-Infective Agents, Local Phase 4

Interventional clinical trials:

(show top 50) (show all 342)
# Name Status NCT ID Phase Drugs
1 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
2 Safety, Long Term Immunogenicity and Lot Consistency Study of Liquid Pentavalent Combination Vaccine Unknown status NCT00877357 Phase 4
3 Safety of Haemophilus Influenza Type b Vaccine When Administered to Korean Children Completed NCT01404962 Phase 4
4 The Safety and Immunogenicity of Haemophilus Influenzae Type b Vaccine in Different Injection Site Completed NCT01761136 Phase 4
5 Assess Safety & Reactogenicity of GSK Biologicals' Hib Vaccine Co-administered With or Without Chinese DTPw Vaccine Completed NCT00158795 Phase 4
6 Study to Eliminate Hib Carriage in Rural Alaska Native Villages Completed NCT00153556 Phase 4
7 The Immediate and Longterm Immune Responses of UK Infants and Young Children to a Booster Dose of Hib Vaccine Completed NCT00197782 Phase 4
8 Study of Long-term Antibody Persistence After a Booster Dose of Menitorix Vaccine Completed NCT00454987 Phase 4
9 Immunogenicity and Safety Study of Infanrix Hexa in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery Completed NCT02422264 Phase 4 Prevnar13
10 Hepatitis B Vaccination in Infants Completed NCT01896596 Phase 4
11 Immunogenicity of the Booster Dose of Two MenC Vaccines Completed NCT00392808 Phase 4
12 Immunogenicity and Safety of PCV13 and Fluad in Adults Aged ≥60 Years Completed NCT02215863 Phase 4
13 Trial to Evaluate Time to Symptom Relief and Elimination of Infecting Bacteria in Treating Sinusitis With Avelox Completed NCT00668304 Phase 4 Avelox (Moxifloxacin, BAY12-8039)
14 Topical Treatment of Bacterial Conjunctivitis and Its Effect on Microbial Flora Completed NCT00312338 Phase 4 VIGAMOX
15 Phase IV Interchangeability Study of a Liquid Pentavalent Combination Vaccine Completed NCT00674908 Phase 4
16 Safety and Immunogenicity Study of a Liquid Pentavalent Combination Vaccine Completed NCT00617812 Phase 4
17 Concomitant Use of Hepatitis A Vaccine, Inactivated With Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate) and Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed Given to Healthy Children 15 Months of Age (V251-068) Completed NCT00289913 Phase 4
18 Assess the Safety & Reactogenicity of DTPa-IPV/Hib Vaccine Administered at 3, 4, 5 & 18 Mths of Age, in Healthy Infants Completed NCT00325156 Phase 4
19 Assessment of the Immunogenicity and Safety of PENTAXIM™ in Philippines Completed NCT00254917 Phase 4
20 Study to Evaluate Antibody Persistence in Children Previously Vaccinated With Infanrix Hexa™ or Infanrix-IPV/Hib™ Completed NCT01358825 Phase 4
21 Comparison of Immunogenicity and Reactogenicity of INFANRIX™ HEXA and HEXAVAC™ Vaccines as a Primary Vaccination Course Completed NCT01457547 Phase 4
22 Immunogenicity and Safety of GSK Biologicals' Infanrix Hexa in Infants Completed NCT00753649 Phase 4
23 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
24 Effectiveness of a Chlorine Dioxide Spray on Dental Plaque and Respiratory Pathogens in Institutionalized Elders Completed NCT03533335 Phase 4
25 Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13® Completed NCT01392378 Phase 4 Paracetamol;Ibuprofen;Paracetamol;Ibuprofen
26 Pneumococcal Vaccines Early and in Combination Completed NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
27 Study of DAPTACEL® Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ Completed NCT00802867 Phase 4
28 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand Completed NCT00255021 Phase 4
29 Safety of PENTAXIM® Given as a Three-Dose Primary Vaccination at 2, 3, and 4 Months of Age in Infants in China Completed NCT01491087 Phase 4
30 Study to Assess if Quinvaxem Can be Interchanged With Other Pentavalent Vaccines During Standard Childhood Vaccination Completed NCT01357720 Phase 4
31 Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency Completed NCT00520494 Phase 4 Vivaglobin
32 Acute Otitis Media (AOM) Therapy Trial in Young Children Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
33 Tripartite International Research for the Elimination of Trachoma Completed NCT01202331 Phase 4 mass treatment with oral azithromycin
34 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. Completed NCT01694108 Phase 4
35 Apnea in Hospitalized Preterm Infants Following the Administration of Routine Childhood Vaccines Recruiting NCT03530124 Phase 4
36 INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol Recruiting NCT03152149 Phase 4 Tiotropium & olodaterol;fluticasone furoate & vilanterol
37 Vaccinating Children After Chemotherapy Active, not recruiting NCT02447718 Phase 4
38 Babies Born Early Antibody Response to Men B Vaccination: BEAR Men B Active, not recruiting NCT03125616 Phase 4
39 Evaluation of Immunogenicity and Safety of a Booster Dose of Infanrix Hexa™ in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery Active, not recruiting NCT02853929 Phase 4
40 Study Comparing DTP-HB-Hib by Disposable-Syringe Jet Injector To Vaccination By Needle And Syringe In Infants Terminated NCT02409095 Phase 4
41 Safety and Immunogenicity of Haemophilus Influenzae Type b Conjugate Vaccine,Freeze-dried Unknown status NCT02560272 Phase 3
42 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Unknown status NCT01619462 Phase 3
43 Randomized Study on Efficacy of Gemifloxacin-based Regimen for Helicobacter Pylori Infection Unknown status NCT02368470 Phase 3 Gemifloxacin-based triple therapy;Standard triple therapy
44 Study in Toddlers (12-18 Months) Comparing a Booster Dose of Vaxem Hib and Hiberix Vaccines for the Prevention of Haemophilus Influenzae Type b Infections in China Completed NCT01025544 Phase 3
45 Safety and Immunogenicity of a Monovalent Conjugated Vaccine Against Haemophilus Influenzae Type b Completed NCT00808392 Phase 3
46 Study in Infants (6-12 Months) Comparing Two Doses of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Vaccine Versus a Tetanus Toxoid-Conjugated Vaccine Available for the Prevention of Haemophilus Influenzae Type b Infections in China Completed NCT01044316 Phase 3
47 A Phase III Clinical Trial of a Haemophilus Influenzae Type b (Hib) Conjugate Vaccine Completed NCT02692859 Phase 3
48 Immunogenicity and Safety of a Booster Dose of Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 365-569 Days Old Healthy Infants Completed NCT01226953 Phase 3
49 Persistency Study After Hib-CRM (Cross-Reacting Material)197 or Hib-TT (Tetanus Toxoid) Vaccines in Chinese Children Completed NCT02139228 Phase 3
50 Study of Modified Process Hib/Hep B Vaccine in Infants (V121-019)(COMPLETED) Completed NCT00441012 Phase 3

Search NIH Clinical Center for Haemophilus Influenzae

Genetic Tests for Haemophilus Influenzae

Anatomical Context for Haemophilus Influenzae

MalaCards organs/tissues related to Haemophilus Influenzae:

41
Colon, Lung, Testes, Neutrophil, Tonsil, Monocytes, Brain

Publications for Haemophilus Influenzae

Articles related to Haemophilus Influenzae:

(show top 50) (show all 1676)
# Title Authors Year
1
Widening the antimicrobial spectrum of esters of bicyclic amines: In vitro effect on gram-positive Streptococcus pneumoniae and gram-negative non-typeable Haemophilus influenzae biofilms. ( 30292448 )
2019
2
A symptomatic anterior mediastinal mass with a simultaneous Haemophilus influenzae infection. ( 30534378 )
2019
3
Immunogenicity and safety of 11- and 12-valent pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccines (11vPHiD-CV, 12vPHiD-CV) in infants: Results from a phase II, randomised, multicentre study. ( 30054160 )
2019
4
Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway. ( 29421524 )
2018
5
Mutant selection window of four quinolone antibiotics against clinical isolates of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. ( 29290527 )
2018
6
Nontypeable Haemophilus Influenzae Sepsis in a Term Neonate. ( 29955021 )
2018
7
Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in I^-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan. ( 29352811 )
2018
8
Carbapenem-non-Susceptible <i>Haemophilus influenzae</i> with Penicillin-Binding Protein 3 containing Amino Acid Insertion. ( 29784853 )
2018
9
Long-term exposure to low-dose <i>Haemophilus influenzae</i> during allergic airway disease drives a steroid-resistant neutrophilic inflammation and promotes airway remodeling. ( 29861841 )
2018
10
Immunologic non-inferiority and safety of the investigational pneumococcal non-typeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) 4-dose vial presentation compared to the licensed PHiD-CV 1-dose vial presentation in infants: A phase III randomized study. ( 29277353 )
2018
11
Pneumococcal phenotype and interaction with nontypeable<i>Haemophilus influenzae</i>as determinants of otitis media progression. ( 29378791 )
2018
12
A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility. ( 29855260 )
2018
13
Coverage of Haemophilus influenzae Type b Conjugate Vaccine for Children in Mainland China: Systematic Review and Meta-Analysis. ( 29957731 )
2018
14
Antibacterial activity of Artemisia asiatica essential oil against some common respiratory infection causing bacterial strains and its mechanism of action in Haemophilus influenzae. ( 29241769 )
2018
15
Molecular diagnosis and characterization of a culture-negative mycotic aneurysm due to ST54 Haemophilus influenzae type b with PBP 3 alterations. ( 29373266 )
2018
16
Phenotypic detection of clinical isolates of Haemophilus influenzae with altered penicillin-binding protein 3. ( 29756174 )
2018
17
The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans. ( 29944882 )
2018
18
Pneumococcal and Haemophilus influenzae type b disease: moving numbers in the right direction. ( 29903364 )
2018
19
Nontypeable Haemophilus influenzae (NTHi). ( 29793827 )
2018
20
Recommendations for application of Haemophilus influenzae PCR diagnostics to respiratory specimens for children living in northern Australia: a retrospective re-analysis. ( 29784027 )
2018
21
Update on non-typeable Haemophilus influenzae-mediated disease and vaccine development. ( 29863956 )
2018
22
MLVA typing of <i>Haemophilus influenzae</i> isolated from two Iranian university hospitals. ( 29922416 )
2018
23
Immunization of preterms with hexavalent combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine: The position of the Italian Pediatric Society. ( 29880242 )
2018
24
Benzylpenicillin versus wide-spectrum beta-lactam antibiotics as empirical treatment of Haemophilus influenzae-associated lower respiratory tract infections in adults; a retrospective propensity score-matched study. ( 29961165 )
2018
25
The adhesins of non-typeable Haemophilus influenzae. ( 29415569 )
2018
26
Changing Epidemiology of Haemophilus influenzae in Children. ( 29233576 )
2018
27
GyrA and/or ParC alterations of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis. ( 29138021 )
2018
28
Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000-15. ( 29903376 )
2018
29
Immunization of preterm infants with GSK's hexavalent combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine: A review of safety and immunogenicity. ( 29336924 )
2018
30
Haemophilus influenzae-protein D specific antibody correlate with protection against acute otitis media in young children. ( 29395516 )
2018
31
Antimicrobial activity of a novel bioengineered honey against non-typeable<i>Haemophilus influenzae</i>biofilms: an in vitro study. ( 29449345 )
2018
32
Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. ( 29180527 )
2018
33
Commentary: The Conquest of Haemophilus influenzae Type B-The Importance of Protecting High-Risk Children. ( 29889812 )
2018
34
Antibodies prevalence against Haemophilus influenzae type b in Jeddah population, Saudi Arabia. I. Total antibodies. ( 29945350 )
2018
35
Infantile Acute Conjunctivitis Induced by β-Lactamase-Positive Amoxicillin-Clavulanate-Resistant Strain of Haemophilus influenzae: A Report of Three Cases. ( 30489345 )
2018
36
Bacterial Meningitis Caused by β-lactamase Non-producing Ampicillin-resistant Haemophilus influenzae Type F in an Immunocompetent Woman. ( 30146561 )
2018
37
A Binge and a Breach: Cardiac Tamponade Caused by Haemophilus influenzae. ( 29518366 )
2018
38
Immunogenicity and safety following primary and booster vaccination with a hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated poliovirus and Haemophilus influenzae type b vaccine: a randomized trial in the United States. ( 30444673 )
2018
39
Review of epiglottitis in the post Haemophilus influenzae type-b vaccine era. ( 30207030 )
2018
40
Effectiveness of pneumococcal Haemophilus influenzae protein D conjugate vaccine against pneumonia in children: A cluster-randomised trial. ( 30145098 )
2018
41
Molecular characterization of fluoroquinolones, macrolides, and imipenem resistance in Haemophilus influenzae: analysis of the mutations in QRDRs and assessment of the extent of the AcrAB-TolC-mediated resistance. ( 30145620 )
2018
42
Risk factors for Haemophilus influenzae and pneumococcal respiratory tract colonization in CVID. ( 30170126 )
2018
43
Clinical and microbiological characteristics of adult invasive Haemophilus influenzae infections: results of a 14-year single-center experience from Hungary. ( 30191513 )
2018
44
Nontypable Haemophilus influenzae Septicemia and Urinary Tract Infection Associated with Renal Stone Disease. ( 30197697 )
2018
45
The return of Pfeiffer's bacillus: Rising incidence of ampicillin resistance in Haemophilus influenzae. ( 30207515 )
2018
46
Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae. ( 30228240 )
2018
47
The Pulmonary Extracellular Matrix Is a Bactericidal Barrier Against Haemophilus influenzae in Chronic Obstructive Pulmonary Disease (COPD): Implications for an in vivo Innate Host Defense Function of Collagen VI. ( 30233584 )
2018
48
Prevalence of Haemophilus influenzae with alteration of PBP 3 sequence over a 1-year period in a French hospital: focus on a clinical failure after ceftriaxone treatment. ( 30249513 )
2018
49
Autoinducer 2 (AI-2) Production by Nontypeable Haemophilus influenzae 86-028NP Promotes Expression of a Predicted Glycosyltransferase That Is a Determinant of Biofilm Maturation, Prevention of Dispersal, and Persistence In Vivo. ( 30249749 )
2018
50
Immunogenicity and safety of the Haemophilus influenzae type b and Neisseria meningitidis serogroups C and Y-tetanus toxoid conjugate vaccine co-administered with human rotavirus, hepatitis A and 13-valent pneumococcal conjugate vaccines: results from a phase III, randomized, multicenter study in infants. ( 30252603 )
2018

Variations for Haemophilus Influenzae

Expression for Haemophilus Influenzae

Search GEO for disease gene expression data for Haemophilus Influenzae.

Pathways for Haemophilus Influenzae

Pathways related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 CFH CLEC7A CXCL8 IL1B LTF TLR2
2
Show member pathways
12.62 CXCL8 IL1B TLR2 TNF
3
Show member pathways
12.45 IL1B TLR2 TNF VTN
4 12.15 TLR2 TNF VTN
5
Show member pathways
12.13 CXCL8 IL1B TLR2 TNF
6
Show member pathways
12.12 CXCL8 TLR2 TNF
7
Show member pathways
12.11 IL1B TLR2 TNF
8
Show member pathways
12.06 CLEC7A IL1B TNF
9 11.99 CLEC7A IL1B TLR2 TNF
10
Show member pathways
11.95 CXCL8 IL1B TLR2 TNF
11
Show member pathways
11.9 IL1B TLR2 TNF
12
Show member pathways
11.89 CXCL8 IL1B TLR2 TNF
13
Show member pathways
11.88 IL1B TLR2 TNF
14 11.85 CXCL8 IL1B TNF
15 11.83 CXCL8 IL1B TF TNF
16 11.82 CXCL8 IL1B TNF
17 11.78 CXCL8 IL1B VTN
18 11.74 CXCL8 IL1B TNF
19 11.71 CXCL8 IL1B TNF
20 11.65 CLEC7A TLR2 VTN
21 11.59 CXCL8 IL1B TNF
22 11.54 CXCL8 IL1B TLR2 TNF
23 11.5 CXCL8 IL1B TNF
24
Show member pathways
11.49 CXCL8 IL1B TNF
25 11.41 CXCL8 IL1B TLR2 TNF
26 11.34 CXCL8 IL1B TNF
27 11.31 IL1B TLR2 TNF
28 11.23 IL1B TNF
29 11.22 IL1B TNF
30 11.18 IL1B TNF
31 11.16 IL1B TNF
32 11.13 IL1B TNF
33 11.06 CXCL8 IL1B TNF
34 11.05 IL1B TLR2
35 11.03 CXCL8 TNF
36 11 CXCL8 IL1B TLR2 TNF
37 10.98 IL1B TNF
38 10.91 CXCL8 TNF
39 10.83 IL1B TNF
40 10.61 CXCL8 IL1B TLR2 TNF

GO Terms for Haemophilus Influenzae

Cellular components related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 LTF TF TLR2 TNF
2 extracellular region GO:0005576 9.5 CFH CXCL8 IL1B LTF TF TNF
3 blood microparticle GO:0072562 9.33 CFH TF VTN
4 extracellular space GO:0005615 9.17 CFH CXCL8 IL1B LTF TF TNF

Biological processes related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.81 IL1B LTF TNF
2 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL1B TNF
3 immune response GO:0006955 9.77 CXCL8 IL1B TLR2 TNF VTN
4 iron ion homeostasis GO:0055072 9.65 LTF TF
5 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.65 IL1B TNF
6 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B TLR2 TNF
7 negative regulation of neurogenesis GO:0050768 9.64 IL1B TNF
8 positive regulation of neutrophil chemotaxis GO:0090023 9.64 CXCL8 IL1B
9 positive regulation of receptor-mediated endocytosis GO:0048260 9.63 TF VTN
10 positive regulation of chemokine production GO:0032722 9.62 TLR2 TNF
11 microglial cell activation GO:0001774 9.61 TLR2 TNF
12 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.61 IL1B VTN
13 embryonic digestive tract development GO:0048566 9.6 CXCL8 TNF
14 negative regulation of lipid catabolic process GO:0050995 9.59 IL1B TNF
15 positive regulation of glial cell proliferation GO:0060252 9.58 IL1B TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.58 IL1B TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.58 IL1B TLR2 TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL1B TNF
20 response to molecule of bacterial origin GO:0002237 9.55 CXCL8 TLR2
21 positive regulation of chemokine biosynthetic process GO:0045080 9.54 IL1B TNF
22 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNF
23 positive regulation of neuroinflammatory response GO:0150078 9.51 IL1B TNF
24 positive regulation of fever generation GO:0031622 9.49 IL1B TNF
25 chronic inflammatory response to antigenic stimulus GO:0002439 9.46 IL1B TNF
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.46 IL1B LTF TLR2 TNF
27 sequestering of triglyceride GO:0030730 9.43 IL1B TNF
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 IL1B TLR2 TNF
29 inflammatory response GO:0006954 9.35 CLEC7A CXCL8 IL1B TLR2 TNF
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IL1B TNF
31 positive regulation of interleukin-8 production GO:0032757 8.8 IL1B TLR2 TNF

Molecular functions related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 CXCL8 IL1B TNF
2 lipopolysaccharide binding GO:0001530 9.26 LTF TLR2
3 heparin binding GO:0008201 9.13 CFH LTF VTN
4 signaling pattern recognition receptor activity GO:0008329 8.62 CLEC7A TLR2

Sources for Haemophilus Influenzae

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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