MCID: HMP009
MIFTS: 46

Haemophilus Influenzae

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Haemophilus Influenzae

Summaries for Haemophilus Influenzae

MalaCards based summary : Haemophilus Influenzae, also known as h. influenzae, is related to bacterial meningitis and septic arthritis. An important gene associated with Haemophilus Influenzae is OMP (Olfactory Marker Protein), and among its related pathways/superpathways are Innate Immune System and TRAF Pathway. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 75 Haemophilus influenzae (formerly called Pfeiffer's bacillus or Bacillus influenzae) is a Gram-negative,... more...

Related Diseases for Haemophilus Influenzae

Diseases related to Haemophilus Influenzae via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 569)
# Related Disease Score Top Affiliating Genes
1 bacterial meningitis 32.3 TNF TLR2 IL1B CXCL8
2 septic arthritis 31.7 TLR2 CXCL8
3 pulmonary disease, chronic obstructive 31.5 TNF TLR2 CXCL8
4 pneumonia 31.4 TNF TLR2 IL1B CXCL8
5 otitis media 31.4 TNF TLR2 IL1B CXCL8
6 neisseria meningitidis infection 31.3 TLR2 OMP
7 endocarditis 31.1 TNF TLR2 CXCL8
8 meningitis 31.0 TNF TLR2 OMP IL1B CXCL8
9 osteomyelitis 31.0 TNF IL1B CXCL8
10 vaginitis 30.8 IL1B CXCL8
11 tonsillitis 30.8 TNF IL1B CXCL8
12 pharyngitis 30.8 IL1B CXCL8
13 suppurative otitis media 30.7 TLR2 IL1B
14 arthritis 30.7 TNF IL1B CXCL8
15 chorioamnionitis 30.6 TNF IL1B CXCL8
16 bacterial infectious disease 30.6 TNF TLR2 IL1B CXCL8
17 lung disease 30.6 TNF TLR2 IL1B CXCL8
18 recurrent corneal erosion 30.4 IL1B CXCL8
19 pyelonephritis 30.4 TNF IL1B CXCL8
20 endometritis 30.4 TNF IL1B
21 aseptic meningitis 30.3 TNF IL1B CXCL8
22 peritonitis 30.2 TNF TLR2 IL1B CXCL8
23 acute respiratory distress syndrome 30.2 TNF IL1B CXCL8
24 prostatitis 30.2 TNF IL1B CXCL8
25 laryngitis 30.2 TNF IL1B
26 glossitis 30.2 TNF IL1B
27 toxic shock syndrome 30.2 TNF TLR2 IL1B CXCL8
28 bacterial sepsis 30.1 TNF CXCL8
29 adult respiratory distress syndrome 30.1 TNF TF CXCL8
30 gastroenteritis 30.0 TNF IL1B CXCL8
31 typhoid fever 29.9 TNF OMP IL1B
32 appendicitis 29.8 TNF IL1B CXCL8
33 duodenal ulcer 29.8 TNF IL1B CXCL8
34 lymphadenitis 29.8 TNF IL1B CXCL8
35 cytomegalovirus infection 29.8 TNF IL1B CXCL8
36 sleep apnea 29.8 TNF IL1B CXCL8
37 tuberculous meningitis 29.8 TNF TLR2 CXCL8
38 synovitis 29.8 TNF IL1B CXCL8
39 middle ear disease 29.8 TNF TLR2 IL1B CXCL8
40 aphthous stomatitis 29.7 TNF TLR2 IL1B
41 pulmonary fibrosis, idiopathic 29.7 TNF IL1B CXCL8
42 chlamydia 29.6 TNF TLR2 IL1B CXCL8
43 hematopoietic stem cell transplantation 29.5 TNF CLEC7A
44 chronic mucocutaneous candidiasis 29.3 TNF IL1B CLEC7A
45 periodontitis 29.3 TNF TLR2 IL1B CXCL8
46 proteasome-associated autoinflammatory syndrome 1 29.3 TNF TLR2 IL1B CXCL8
47 asthma 28.8 VTN TNF IL1B CXCL8
48 haemophilus meningitis 12.0
49 epiglottitis 11.9
50 guillain-barre syndrome 11.8

Graphical network of the top 20 diseases related to Haemophilus Influenzae:



Diseases related to Haemophilus Influenzae

Symptoms & Phenotypes for Haemophilus Influenzae

MGI Mouse Phenotypes related to Haemophilus Influenzae:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CFH CLEC7A IL1B LTF TF TLR2
2 homeostasis/metabolism MP:0005376 9.28 CFH CLEC7A IL1B LTF OMP TF

Drugs & Therapeutics for Haemophilus Influenzae

Drugs for Haemophilus Influenzae (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 189)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
6
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
8 Strawberry Approved Phase 4
9
Olodaterol Approved Phase 4 868049-49-4
10
Temocillin Approved, Investigational Phase 4 66148-78-5
11
Budesonide Approved Phase 4 51333-22-3 63006 5281004
12
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
13 Chlorine dioxide Investigational Phase 4 10049-04-4
14 Anti-Inflammatory Agents Phase 4
15 Methylprednisolone Acetate Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 Prednisolone acetate Phase 4
18 Diphtheria Antitoxin Phase 4
19 Antitoxins Phase 4
20 Tetanus Antitoxin Phase 4
21 Protective Agents Phase 4
22 Antidotes Phase 4
23 Disinfectants Phase 4
24 Chlorhexidine gluconate Phase 4
25 Anti-Infective Agents, Local Phase 4
26 Amoxicillin-Potassium Clavulanate Combination Phase 4
27 beta-Lactamase Inhibitors Phase 4
28 Micronutrients Phase 4
29 Trace Elements Phase 4
30 Nutrients Phase 4
31 Antitubercular Agents Phase 4
32 Parasympatholytics Phase 4
33 Cholinergic Agents Phase 4
34 Tiotropium Bromide Phase 4 136310-93-5
35 Cholinergic Antagonists Phase 4
36 penicillins Phase 4
37 Aluminum phosphate Phase 4
38 Neurotransmitter Agents Phase 4
39 Sympathomimetics Phase 4
40 Adrenergic Agonists Phase 4
41 Adrenergic beta-2 Receptor Agonists Phase 4
42 Adrenergic beta-Agonists Phase 4
43 glucocorticoids Phase 4
44 Hormones Phase 4
45
Salmeterol xinafoate Phase 4 94749-08-3 56801
46 Adrenergic Agents Phase 4
47 Formoterol Fumarate Phase 4
48 Hormone Antagonists Phase 4
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
50 Anticonvulsants Phase 4

Interventional clinical trials:

(show top 50) (show all 255)
# Name Status NCT ID Phase Drugs
1 Open Label Multicentric Randomized Phase IV Post Marketing Safety, Immunogenicity and Lot-to-Lot Consistency Analysis of Shan 5 [DTPwHB-Hib (Liquid) Pentavalent Combination Vaccine] in Indian Infants Unknown status NCT00877357 Phase 4
2 Clinical Relevance of Middle Meatal Bacteriology During Acute Respiratory Infection in Children - Randomised, Double-Blinded Clinical Study Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
3 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
4 Phase 4 Study of Haemophilus Influenzae Type b Vaccine in Different Injection Site Completed NCT01761136 Phase 4
5 An Open Label Multicentric Study to Evaluate the Immunogenicity and Safety of Indigenously Developed DTPwHB-Hib (Liquid) Pentavalent Combination Vaccine (Shan 5) in Indian Infants. Completed NCT00617812 Phase 4
6 Immunogenicity and Safety of Sanofi Pasteur Pentaxim Combined Vaccine in Infants in Thailand Completed NCT00255021 Phase 4
7 The Immediate and Longterm Immune Responses of UK Infants and Young Children to a Booster Dose of Hib Vaccine Completed NCT00197782 Phase 4
8 A Post Marketing Surveillance Study to Monitor the Reactogenicity and Safety of Vaxem™Hib When Administered According to the Prescribing Information in Korea Completed NCT01404962 Phase 4
9 A Single Blind, Multicentric, Comparative, Vaccine Interchangeability Trial of Shan 5 (Liquid) and Easy Five (Liquid) [Diphtheria-Tetanus- Pertussis, Hepatitis B and Hib Pentavalent Combination Vaccines] in Indian Infants. Completed NCT00674908 Phase 4
10 A Randomized Clinical Trial on the Effect of a Chlorine Dioxide Spray on Dental Plaque and Respiratory Pathogens in Institutionalized Elders Completed NCT03533335 Phase 4
11 Safety of the DTacP-IPV//PRP~T Combined Vaccine (PENTAXIM®) Given as a Three-Dose Primary Vaccination at 2, 3, and 4 Months of Age in Infants in China Completed NCT01491087 Phase 4
12 Safety and Immunogenicity of DAPTACEL® (CP10/5/5/3DT Aventis Pasteur 5-component Pertussis Vaccine in Combination With Tetanus and Diphtheria Toxoids Adsorbed) Administered as a 5th Dose in 4 to 6-Year-Old Children Previously Immunized With PENTACEL™ (HCP20/20/5/3DT-mIPV//PRP-T) Completed NCT00802867 Phase 4
13 A Phase IV, Single-blind, Randomized, Controlled, Monocentric Study to Assess the Interchangeability of Quinvaxem (DTwP-HepB-Hib) as the 2nd and 3rd Dose After Initial Vaccination With Tritanrix HB+Hib (DTwP-HepB/Hib) With Respect to Safety and Immunogenicity in Healthy Infants at 6, 10 and 14 Weeks of Age Completed NCT01357720 Phase 4
14 Assessment of Long-term Antibody Persistence After a Booster Dose of GSK Biologicals' Hib & Meningococcal C Vaccine (Menitorix™) 811936 Given at 12-15 Months of Age to Subjects Primed With 3 Doses of Menitorix™ at 2, 3, 4 Months of Age Completed NCT00454987 Phase 4
15 Immunogenicity and Safety Study of GSK Biologicals' Combined Diphtheria-tetanus-acellular Pertussis-hepatitis B-inactivated Polio-virus and Haemophilus Influenzae Type b Vaccine (Infanrix Hexa™) (217744) in Healthy Infants Born to Mothers Vaccinated With Boostrix™ During Pregnancy or Immediately Post-delivery Completed NCT02422264 Phase 4 Prevnar13
16 An Open-Label Multi-Center Study of Eculizumab in Children and Adolescents With a Diagnosis of Paroxysmal Nocturnal Hemoglobinuria Completed NCT00867932 Phase 4 Eculizumab
17 A Randomised Controlled Trial of Pneumococcal Conjugate Vaccines Synflorix and Prevenar13 in Sequence or Alone in High-risk Indigenous Infants (PREV-IX_COMBO): Immunogenicity, Carriage and Otitis Media Outcomes Completed NCT01174849 Phase 4 Synflorix;Prevenar13;COMBO
18 A Phase IV Study to Evaluate the Primary and Booster Immune Responses of UK Infants Receiving a Licensed 6-in-1 DTaP/IPV/Hib/HBV Vaccine (Infanrix-HexaTM) With a 13-valent Pneumococcal Conjugate Vaccine and Incorporating a Randomisation Study of a Single Dose of 3 Different Meningococcal Group C Conjugate Vaccines at 3 Months of Age Completed NCT01896596 Phase 4
19 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
20 Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children Completed NCT00968370 Phase 4
21 Efficacy of Antimicrobials in Young Children With Acute Otitis Media (AOM) Completed NCT00377260 Phase 4 amoxicillin-clavulanate;Placebo
22 A Randomised Controlled Trial Comparing Two-Dose Priming With the 10-Valent Pneumococcal Conjugate Vaccine at 6 and 10 Weeks to 6 and 14 Weeks in Nepali Children Completed NCT02385513 Phase 4
23 INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation With Tiotropium and Olodaterol Recruiting NCT03152149 Phase 4 Tiotropium & olodaterol;fluticasone furoate & vilanterol
24 Temocillin Pharmacokinetics in Paediatrics Recruiting NCT02260102 Phase 4 Temocillin
25 Pneumococcal Conjugate Vaccine (PCV) Schedules for the Northern Territory (NT): Randomised Controlled Trial of Booster Vaccines to Broaden and Strengthen Protection From Invasive and Mucosal Infections. Active, not recruiting NCT01735084 Phase 4
26 Vaccinating Children After Chemotherapy for Acute Lymphoblastic Leukemia: A Canadian Immunization Research Network Study Active, not recruiting NCT02447718 Phase 4
27 Babies Born Early Antibody Response to Men B Vaccination: A Phase IV Multicentre Randomised Study to Evaluate the Primary and Booster Immune Responses in UK Preterm Infants Receiving Routine Immunisations and Incorporating a Three Dose Versus a Two Dose Schedule of 4CMenB (Bexsero®) for Primary Immunisation. Active, not recruiting NCT03125616 Phase 4
28 Investigating the Mechanism of Inhaled Corticosteroids Associated Pneumonia by Longitudinal Characterisation of the Airway Microbiome in Patients With Severe COPD Active, not recruiting NCT02972476 Phase 4 Budesonide & formoterol fumarate and Aclidinium bromide;Fluticasone 500 & salmeterol and Aclidinium bromide;Fluticasone 250 & salmeterol and Aclidinium bromide;Aclidinium bromide & formoterol fumarate
29 A Prospective, Open-label, Interventional Phase IV Study to Assess the Safety of EupentaTM Inj. {Fully Liquid Pentavalent Vaccine, Adsorbed Diphtheria-Tetanus-whole-cell Pertussis-Hepatitis B (rDNA [Recombinant-deoxyribonucleic Acid])-Haemophilus Influenzae Type b Conjugate Vaccine} Not yet recruiting NCT04056728 Phase 4
30 A Phase IV, Non-Inferiority, Observer Blind, Randomized Clinical Study Comparing Safety And Immunogenicity Of DTP-HB-Hib Vaccination by Disposable-Syringe Jet Injector To Vaccination By Needle And Syringe In Healthy Infants In India Terminated NCT02409095 Phase 4
31 Assessment of Antibody Responses in UK Infants Given Two Doses of 10 or 13 Valent Pneumococcal Conjugate Vaccine (PCV) in Infancy and PCV13 in the Second Year of Life (Study Code: Pneumococcal in New Combinations (PINC)) Withdrawn NCT02918708 Phase 4
32 A Phase III, Double Blind, Parallel-controlled, Randomised Study to Evaluate the Safety and Immunogenicity of Haemophilus Influenzae Type b Conjugate Vaccine in Healthy Children 2 Months to 5 Years of Age Unknown status NCT02560272 Phase 3
33 A Phase III, Randomized, Double Blind, Placebo Controlled Trial to Evaluate the Protective Efficacy of Three Doses of Oral Rotavirus Vaccine (ORV) 116E, Against Severe Rotavirus Gastroenteritis in Infants Unknown status NCT01305109 Phase 3
34 An Open Label Trial of Azithromycin in Chronic Productive Cough Unknown status NCT02196493 Phase 3 Azithromycin
35 A Study of Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines to Inform Policy Regarding Pneumococcal Vaccination of Papua New Guinean Children Unknown status NCT01619462 Phase 3
36 Randomized Study on Efficacy of Gemifloxacin-based Regimen for Helicobacter Pylori Infection Unknown status NCT02368470 Phase 3 Gemifloxacin-based triple therapy;Standard triple therapy
37 Randomized Controlled Trial Comparing Long and Short Duration of Antibiotic Prophylaxis for Patients Undergoing Sinus Lift Surgery Unknown status NCT02764710 Phase 3 Amoxicillin-Potassium Clavulanate Combination
38 A Single-blind, Randomized, Controlled, Multinational Study for the Evaluation of Safety of GlaxoSmithKline (GSK) Biologicals' Investigational Vaccination Regimen Compared to Monovalent Haemophilus Influenzae Type b (Hib) Control Vaccine in Healthy Infants at 2, 4, 6, and 12 to 15 Months of Age. Completed NCT00345579 Phase 3
39 Assessment of the Immunogenicity and Safety of Quinvaxem Vaccine (DTwP-HepB-Hib) Against Diphtheria, Pertussis, Tetanus, Hepatitis B and Diseases Caused by H. Influenzae Among Healthy Vietnamese Children Completed NCT01362517 Phase 3
40 A Phase III Open Label, Multi-Center Pediatric Study in China Comparing Booster Doses of Vaxem Hib and Hiberix Vaccines for the Prevention of Haemophilus Influenzae Type b (Hib) Infection Completed NCT01025544 Phase 3
41 Single-blind, Randomized, Controlled, Multinational Study for the Evaluation of Safety of GSK Biologicals' Hib-MenCY-TT Vaccine Compared to Monovalent Hib Control Vaccine in Healthy Infants at 2, 4, 6, and 12 to 15 Months of Age. Completed NCT00345683 Phase 3
42 Evaluation of Effectiveness of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Against Invasive Disease Completed NCT00861380 Phase 3
43 Impact on Nasopharyngeal Carriage, Acute Otitis Media, Immunogenicity and Safety of GSK Biologicals' Pneumococcal Conjugate Vaccine 1024850A Completed NCT00839254 Phase 3
44 A Phase III, Observer-blind, Randomized, Controlled, Multicenter Study to Investigate Immunogenicity and Safety of Haemophilus Influenzae Type b Vaccine in 2 - 4 Months Old Healthy Infants in China, According to the Recommended Regimen of 3 Intramuscular Doses Given One Month Apart Completed NCT00808392 Phase 3
45 A Phase III Observer Blind Single-Coordinating Center Pediatric Study in China Comparing a Booster Dose of Vaxem™ Hib to HIBERIX® When Given as Part of a Local Dosing Regimen in Infants Completed NCT01226953 Phase 3
46 A Phase IIIb, Controlled, Open Label, Single-Center, Persistency, Extension Study in Chinese Children After a 2+1 Dose Series of Either CRM197-Conjugate Haemophilus Influenzae Type b Vaccine or Tetanus Toxoid-Conjugate Haemophilus Influenzae Type b Vaccine Completed NCT02139228 Phase 3
47 A Multicentre, Comparative, Two-arm, Parallel-group, Double-blind, Randomized Phase III Study to Assess Immunogenicity and Safety of LBVH0101 (Haemophilus Influenzae Type b Tetanus Toxoid Conjugate Vaccine) Compared With Hiberix™ Vaccine in Healthy Infants at Two, Four and Six Months of Age Completed NCT01019772 Phase 3
48 A Phase III Observer-blind, Randomized, Controlled, Single-coordinating Center Study to Investigate Immunogenicity and Safety of a Monovalent Glycoprotein-conjugated (Diptheria Toxin -CRM197) Hib Vaccine in 13-59 Months Old Healthy Children in China, According to the Recommended Regimen of 1 Dose Completed NCT01125527 Phase 3
49 A Phase III Observer-Blind, Randomized, Controlled, Single-Coordinating Center Pediatric Study in China Comparing Two Doses of a Monovalent Glycoprotein-Conjugated (Diptheria Toxin -CRM197) Vaccine Versus a Tetanus Toxoid-Conjugated Vaccine Using a Local Dosing Regimen in Infants Completed NCT01044316 Phase 3
50 A Study in Healthy Infants of the Safety, Tolerability, and Immunogenicity of Haemophilus Influenzae, Type b/Hepatitis B Vaccine Manufactured With a Modified Process Completed NCT00441012 Phase 3

Search NIH Clinical Center for Haemophilus Influenzae

Genetic Tests for Haemophilus Influenzae

Anatomical Context for Haemophilus Influenzae

MalaCards organs/tissues related to Haemophilus Influenzae:

41
Testes, Colon, Lung, Tonsil, Neutrophil, B Cells, Bone

Publications for Haemophilus Influenzae

Articles related to Haemophilus Influenzae:

(show top 50) (show all 18238)
# Title Authors PMID Year
1
Moonlighting of Haemophilus influenzae heme acquisition systems contributes to the host airway-pathogen interplay in a coordinated manner. 38
30973092 2019
2
Paediatric orbital and periorbital infections. 38
31261188 2019
3
Sudden Infant Death After Vaccination: Survey of Forensic Autopsy Files. 38
31205057 2019
4
Causes of Pediatric Meningitis in Botswana: Results From a 16-Year National Meningitis Audit. 38
31261367 2019
5
Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for clinical microbiology in 2014: General view of the pathogens' antibacterial susceptibility. 38
31196772 2019
6
Invasive Haemophilus influenzae Disease at Texas Children's Hospital, 2011 to 2018. 38
31107422 2019
7
Translating Recent Microbiome Insights in Otitis Media into Probiotic Strategies. 38
31270125 2019
8
Genetic characteristics and antibiotic resistance of Haemophilus influenzae isolates from pediatric patients with acute otitis media after introduction of 13-valent pneumococcal conjugate vaccine in Japan. 38
30987951 2019
9
Double-blind, placebo-controlled, randomized trial on low-dose azithromycin prophylaxis in patients with primary antibody deficiencies. 38
30910492 2019
10
Investigation of the susceptibility trends in Japan to fluoroquinolones and other antimicrobial agents in a nationwide collection of clinical isolates: A longitudinal analysis from 1994 to 2016. 38
30954447 2019
11
A Protein E-PilA Fusion Protein Shows Vaccine Potential against Nontypeable Haemophilus influenzae in Mice and Chinchillas. 38
31109946 2019
12
Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable Haemophilus influenzae Vaccine. 38
31085711 2019
13
Underlying glycans determine the ability of sialylated lipooligosaccharide to protect nontypeable Haemophilus influenzae from serum IgM and complement. 38
31405955 2019
14
Shaping markets to benefit global health - A 15-year history and lessons learned from the pentavalent vaccine market. 38
31384748 2019
15
Ceftaroline fosamil as a potential treatment option for Staphylococcus aureus community-acquired pneumonia in adults. 38
31404620 2019
16
[Epiglottitis due to Haemophilus influenzae type b in the vaccination era: pediatric clinical case]. 38
31339284 2019
17
Discovery and contribution of nontypeable Haemophilus influenzae NTHI1441 to human respiratory epithelial cell invasion. 38
31427451 2019
18
Vaccination Status in Pediatric Solid-Organ Transplant Recipients and Their Household Members. 38
31050613 2019
19
The risk of non-specific hospitalised infections following MMR vaccination given with and without inactivated vaccines in the second year of life. Comparative self-controlled case-series study in England. 38
31375437 2019
20
Direct interactions with influenza promote bacterial adherence during respiratory infections. 38
31110359 2019
21
Talk to Patients About: Hib. 38
31369129 2019
22
Integration of hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B virus, inactivated poliomyelitis and Haemophilus influenzae type b conjugate vaccine within existing national recommendations following a birth dose of monovalent hepatitis B virus vaccine: results of a systematic review in the Asia Pacific region. 38
31328999 2019
23
Streptococcus pneumoniae and Haemophilus influenzae nasopharyngeal molecular detection in children with acute respiratory tract infection in SANADOR Hospital, Romania. 38
31389781 2019
24
Immunogenicity of the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) administered concomitantly with the meningococcal serogroup B (4CMenB) vaccine in infants: A post-hoc analysis in a phase 3b, randomised, controlled trial. 38
31327652 2019
25
Serum IgM and C-Reactive Protein Binding to Phosphorylcholine of Nontypeable Haemophilus influenzae Increases Complement-Mediated Killing. 38
31109949 2019
26
The Laminin Interactome: A Multifactorial Laminin-Binding Strategy by Nontypeable Haemophilus influenzae for Effective Adherence and Colonization. 38
31034569 2019
27
Earlier generation quinolones can be useful in identifying Haemophilus influenzae strains with low susceptibility to quinolone isolated from paediatric patients. 38
31215858 2019
28
Haemophilus influenzae type b vaccination and anthropometric, cognitive, and schooling outcomes among Indian children. 38
31180594 2019
29
Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma. 38
30875247 2019
30
[Clinical characteristics of 84 children with invasive Haemophilus influenzae infection from 2014 to 2018]. 38
31352743 2019
31
Identification of Haemophilus influenzae serotype e strains missing the fucK gene in clinical isolates from Japan. 38
31368885 2019
32
Constituents from Nauclea latifolia with Anti-Haemophilus influenzae Type b Inhibitory Activities. 38
31429278 2019
33
Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells. 38
30503566 2019
34
Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms. 38
31314141 2019
35
Efficacy of Intraoperative Antiseptic Techniques in the Prevention of Periprosthetic Joint Infection: Superiority of Betadine. 38
30878506 2019
36
The association between pneumococcal vaccination, ethnicity, and the nasopharyngeal microbiota of children in Fiji. 38
31311598 2019
37
Pneumococcal susceptibility to antibiotics in carriage: a 17 year time series analysis of the adaptive evolution of non-vaccine emerging serotypes to a new selective pressure environment. 38
31280295 2019
38
Serum antibody response to Moraxella catarrhalis proteins in stringently defined otitis prone children. 38
28755833 2019
39
Use of the 10-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) in an Australian Indigenous paediatric population does not alter the prevalence of nontypeable Haemophilus influenzae without the protein D gene. 38
31164306 2019
40
The Effect of the 10-Valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine on H. influenzae in Healthy Carriers and Middle Ear Infections in Iceland. 38
31068412 2019
41
Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia. 38
30649895 2019
42
Many women with Turner syndrome lack protective antibodies to common respiratory pathogens, Haemophilus influenzae type B and Streptococcus Pneumoniae. 38
30916795 2019
43
Virologic study of acute lower respiratory tract infections in children admitted to the paediatric department of Blida University Hospital, Algeria. 38
31193119 2019
44
Community-Acquired Bacterial Meningitis In Adults With Cerebrospinal Fluid Leakage. 38
31300817 2019
45
Conjugate vaccines dramatically reshaped the epidemiology of bacterial meningitis in a well-defined child population. 38
31365152 2019
46
Draft Whole-Genome Sequences of Haemophilus influenzae Biogroup aegyptius Strains Isolated from Five Brazilian Purpuric Fever Cases and One Conjunctivitis Case. 38
31346025 2019
47
The Contribution of Geogenic Particulate Matter to Lung Disease in Indigenous Children. 38
31344807 2019
48
IL-17C-mediated innate inflammation decreases the response to PD-1 blockade in a model of Kras-driven lung cancer. 38
31316109 2019
49
Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages. 38
31320451 2019
50
Transcriptome Sequencing Data Sets for Determining Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae Strains Isolated from Patients with Chronic Obstructive Pulmonary Disease. 38
31320413 2019

Variations for Haemophilus Influenzae

Expression for Haemophilus Influenzae

Search GEO for disease gene expression data for Haemophilus Influenzae.

Pathways for Haemophilus Influenzae

Pathways related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 VTN TNF TLR2 LTF IL1B CXCL8
2
Show member pathways
12.45 VTN TNF TLR2 IL1B
3 12.15 VTN TNF TLR2
4
Show member pathways
12.13 TNF TLR2 IL1B CXCL8
5
Show member pathways
12.11 TNF TLR2 CXCL8
6
Show member pathways
12.1 TNF TLR2 IL1B
7
Show member pathways
12.05 TNF IL1B CLEC7A
8 11.99 TNF TLR2 IL1B CLEC7A
9
Show member pathways
11.95 TNF TLR2 IL1B CXCL8
10
Show member pathways
11.9 TNF TLR2 IL1B
11
Show member pathways
11.89 TNF TLR2 IL1B CXCL8
12
Show member pathways
11.88 TNF TLR2 IL1B
13 11.85 TNF IL1B CXCL8
14 11.83 TNF TF IL1B CXCL8
15 11.82 TNF IL1B CXCL8
16 11.78 VTN IL1B CXCL8
17 11.74 TNF IL1B CXCL8
18 11.74 TNF IL1B CXCL8
19 11.65 VTN TLR2 CLEC7A
20 11.59 TNF IL1B CXCL8
21 11.57 TNF TLR2 IL1B CXCL8
22
Show member pathways
11.5 TNF IL1B CXCL8
23 11.49 TNF IL1B CXCL8
24 11.43 TNF TLR2 IL1B CXCL8
25 11.34 TNF IL1B CXCL8
26 11.31 TNF TLR2 IL1B
27 11.24 TNF IL1B
28 11.22 TNF IL1B
29 11.18 TNF IL1B
30 11.16 TNF IL1B
31 11.13 TNF IL1B
32 11.06 TNF IL1B CXCL8
33 11.04 TLR2 IL1B
34 11.02 TNF CXCL8
35 11 TNF TLR2 IL1B CXCL8
36 10.98 TNF IL1B
37 10.91 TNF CXCL8
38 10.83 TNF IL1B
39 10.61 TNF TLR2 IL1B CXCL8

GO Terms for Haemophilus Influenzae

Cellular components related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.56 TNF TLR2 TF LTF
2 extracellular region GO:0005576 9.5 VTN TNF TF LTF IL1B CXCL8
3 blood microparticle GO:0072562 9.33 VTN TF CFH
4 extracellular space GO:0005615 9.17 VTN TNF TF LTF IL1B CXCL8

Biological processes related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.81 TNF LTF IL1B
2 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL1B CXCL8
3 immune response GO:0006955 9.77 VTN TNF TLR2 IL1B CXCL8
4 iron ion homeostasis GO:0055072 9.65 TF LTF
5 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.65 TNF IL1B
6 positive regulation of interleukin-6 production GO:0032755 9.65 TNF TLR2 IL1B
7 negative regulation of neurogenesis GO:0050768 9.64 TNF IL1B
8 positive regulation of receptor-mediated endocytosis GO:0048260 9.63 VTN TF
9 positive regulation of chemokine production GO:0032722 9.62 TNF TLR2
10 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.61 VTN IL1B
11 microglial cell activation GO:0001774 9.61 TNF TLR2
12 embryonic digestive tract development GO:0048566 9.6 TNF CXCL8
13 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.59 TNF IL1B
14 positive regulation of glial cell proliferation GO:0060252 9.58 TNF IL1B
15 negative regulation of lipid catabolic process GO:0050995 9.58 TNF IL1B
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.58 TNF TLR2 IL1B
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 TNF IL1B
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 TNF IL1B
19 response to molecule of bacterial origin GO:0002237 9.55 TLR2 CXCL8
20 positive regulation of chemokine biosynthetic process GO:0045080 9.54 TNF IL1B
21 regulation of establishment of endothelial barrier GO:1903140 9.52 TNF IL1B
22 positive regulation of neuroinflammatory response GO:0150078 9.51 TNF IL1B
23 positive regulation of fever generation GO:0031622 9.49 TNF IL1B
24 sequestering of triglyceride GO:0030730 9.46 TNF IL1B
25 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.46 TNF TLR2 LTF IL1B
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 TNF TLR2 IL1B
27 inflammatory response GO:0006954 9.35 TNF TLR2 IL1B CXCL8 CLEC7A
28 positive regulation of neutrophil chemotaxis GO:0090023 9.34 CXCL8
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IL1B
30 chronic inflammatory response to antigenic stimulus GO:0002439 9.13 TNF
31 positive regulation of interleukin-8 production GO:0032757 8.8 TNF TLR2 IL1B

Molecular functions related to Haemophilus Influenzae according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 TNF IL1B CXCL8
2 lipopolysaccharide binding GO:0001530 9.26 TLR2 LTF
3 heparin binding GO:0008201 9.13 VTN LTF CFH
4 signaling pattern recognition receptor activity GO:0008329 8.62 TLR2 CLEC7A

Sources for Haemophilus Influenzae

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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